Rift Valley fever virus

Summary

Alias: RVFV

Top Publications

  1. Bird B, Khristova M, Rollin P, Ksiazek T, Nichol S. Complete genome analysis of 33 ecologically and biologically diverse Rift Valley fever virus strains reveals widespread virus movement and low genetic diversity due to recent common ancestry. J Virol. 2007;81:2805-16 pubmed
    ..In addition to insights into the evolution and ecology of RVF virus, these genomic data also provide a foundation for the design of molecular detection assays and prototype vaccines useful in combating this important disease. ..
  2. Kalveram B, Lihoradova O, Ikegami T. NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62. J Virol. 2011;85:6234-43 pubmed publisher
    b>Rift Valley fever virus (RVFV; family Bunyaviridae, genus Phlebovirus) is an important emerging pathogen of humans and ruminants...
  3. Reperant L, Brown I, Haenen O, de Jong M, Osterhaus A, Papa A, et al. Companion Animals as a Source of Viruses for Human Beings and Food Production Animals. J Comp Pathol. 2016;155:S41-53 pubmed publisher
    ..bluetongue virus, African swine fever virus, foot-and-mouth disease virus, lumpy skin disease virus, Rift Valley fever virus, porcine circovirus, classical swine fever virus, equine herpesvirus 9, peste des petits ruminants virus ..
  4. Liu J, Ochieng C, Wiersma S, Ströher U, Towner J, Whitmer S, et al. Development of a TaqMan Array Card for Acute-Febrile-Illness Outbreak Investigation and Surveillance of Emerging Pathogens, Including Ebola Virus. J Clin Microbiol. 2016;54:49-58 pubmed publisher
    ..Sudan virus, hantaviruses [Hantaan and Seoul], hepatitis E, Marburg, Nipah virus, o'nyong-nyong virus, Rift Valley fever virus, West Nile virus, and yellow fever virus), 8 bacteria (Bartonella spp., Brucella spp...
  5. Wang H, Wu S, Jiang L, Xiao R, Li T, Mei L, et al. Establishment and optimization of a liquid bead array for the simultaneous detection of ten insect-borne pathogens. Parasit Vectors. 2018;11:442 pubmed publisher
    ..African swine fever virus, West Nile fever virus, Borrelia burgdorferi, vesicular stomatitis virus, Rift Valley fever virus, Ebola virus and Schmalenberg's disease virus, and 3000 clinical samples were tested for practicability...
  6. Matsuno K, Kajihara M, Nakao R, Nao N, Mori Kajihara A, Muramatsu M, et al. The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus. mSphere. 2018;3: pubmed publisher
    ..understanding the mechanisms underlying the evolution and emergence of pathogenic phleboviruses, such as Rift Valley fever virus and SFTSV/HRTV...
  7. Mendenhall M, Wong M, Skirpstunas R, Morrey J, Gowen B. Punta Toro virus (Bunyaviridae, Phlebovirus) infection in mice: strain differences in pathogenesis and host interferon response. Virology. 2009;395:143-51 pubmed publisher
    ..is likely due to the ability of PTV-A to suppress interferon (IFN)-beta similarly to that described for Rift Valley fever virus. Here we investigated strain differences in PTV pathogenesis and the IFN response in mice...
  8. Halldorsson S, Li S, Li M, Harlos K, Bowden T, Huiskonen J. Shielding and activation of a viral membrane fusion protein. Nat Commun. 2018;9:349 pubmed publisher
    ..Here, we address the fusion mechanism of Rift Valley fever virus. We determine the crystal structure of the Gn glycoprotein and fit it with the Gc fusion protein into ..
  9. Hornak K, Lanchy J, Lodmell J. RNA Encapsidation and Packaging in the Phleboviruses. Viruses. 2016;8: pubmed publisher
    ..Bunyaviridae, the Phlebovirus genus includes several important human and animal pathogens, including Rift Valley fever virus (RVFV), severe fever with thrombocytopenia syndrome virus (SFTSV), Uukuniemi virus (UUKV), and the ..

More Information

Publications157 found, 100 shown here

  1. Yi F, Guo J, Dabbagh D, Spear M, He S, Kehn Hall K, et al. Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1. J Virol. 2017;91: pubmed publisher
    ..In addition, R10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1), suggesting that ..
  2. Zumla A, Dar O, Kock R, Muturi M, Ntoumi F, Kaleebu P, et al. Taking forward a 'One Health' approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential. Int J Infect Dis. 2016;47:5-9 pubmed publisher
    ..virus, Yellow fever virus, Ebola virus, Nipah virus, Lassa Fever virus, Hanta virus, Dengue fever virus, Rift Valley fever virus, Crimean-Congo haemorrhagic fever virus, severe acute respiratory syndrome coronavirus, highly pathogenic ..
  3. Fèvre E, de Glanville W, Thomas L, Cook E, Kariuki S, Wamae C. An integrated study of human and animal infectious disease in the Lake Victoria crescent small-holder crop-livestock production system, Kenya. BMC Infect Dis. 2017;17:457 pubmed publisher
    ..was observed in cattle (0.26% (95% CI 0-0.56). This was higher for Rift Valley fever virus (1.4% (95% CI 0.5-2.22)) and C. burnetii (10.0% (95% CI 7.7-12.2)). The prevalence of Taenia spp...
  4. Samuel G, Adelman Z, Myles K. Antiviral Immunity and Virus-Mediated Antagonism in Disease Vector Mosquitoes. Trends Microbiol. 2018;26:447-461 pubmed publisher
    ..DENV 1-4), Japanese encephalitis virus (JEV), yellow fever virus (YFV), chikungunya virus (CHIKV), and Rift Valley fever virus (RVFV)...
  5. Spiegel M, Plegge T, Pohlmann S. The Role of Phlebovirus Glycoproteins in Viral Entry, Assembly and Release. Viruses. 2016;8: pubmed publisher
    ..Bunyaviridae are transmitted by mosquitos and ticks to humans and include highly pathogenic agents like Rift Valley fever virus (RVFV) and severe fever with thrombocytopenia syndrome virus (SFTSV) as well as viruses that do not cause ..
  6. Vadivalagan C, Karthika P, Murugan K, Panneerselvam C, Del Serrone P, Benelli G. Exploring genetic variation in haplotypes of the filariasis vector Culex quinquefasciatus (Diptera: Culicidae) through DNA barcoding. Acta Trop. 2017;169:43-50 pubmed publisher
    ..In the African region, it vectors the Rift Valley fever virus, while in the USA it transmits West Nile, St. Louis encephalitis and Western equine encephalitis virus...
  7. Badolo A, Burt F, Daniel S, Fearns R, Gudo E, Kielian M, et al. Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018. Antiviral Res. 2019;162:142-150 pubmed publisher
    ..coronaviruses, filoviruses (Ebola), influenza viruses, Crimean Congo hemorrhagic fever virus, Rift Valley fever Virus, Lassa virus, and others...
  8. Wernike K, Hoffmann B, Beer M. Simultaneous detection of five notifiable viral diseases of cattle by single-tube multiplex real-time RT-PCR. J Virol Methods. 2015;217:28-35 pubmed publisher
    ..for Animal Health, namely foot-and-mouth disease virus, epizootic haemorrhagic disease virus, and Rift Valley fever virus, was integrated using the identical fluorophore for the respective RT-qPCR assays...
  9. Weber M, Weber F. Monitoring activation of the antiviral pattern recognition receptors RIG-I and PKR by limited protease digestion and native PAGE. J Vis Exp. 2014;:e51415 pubmed publisher
    ..methods to monitor RIG-I and PKR stimulation upon infection with an established interferon inducer, the Rift Valley fever virus mutant clone 13 (Cl 13)...
  10. Charley P, Wilusz C, Wilusz J. Identification of phlebovirus and arenavirus RNA sequences that stall and repress the exoribonuclease XRN1. J Biol Chem. 2018;293:285-295 pubmed publisher
    ..series of biochemical assays to demonstrate that the 3'-terminal portion of the nucleocapsid (N) mRNA of Rift Valley fever virus, a phlebovirus of the Bunyaviridae family, also can effectively stall and repress XRN1...
  11. Monaco F, Cosseddu G, Doumbia B, Madani H, El Mellouli F, Jiménez Clavero M, et al. First External Quality Assessment of Molecular and Serological Detection of Rift Valley Fever in the Western Mediterranean Region. PLoS ONE. 2015;10:e0142129 pubmed publisher
    ..testing (external quality assessment--EQA) for the detection of the viral genome and antibodies of RVF virus (RVFV) was carried out from October 2013 to February 2014...
  12. Mint Mohamed Lemine A, Ould Lemrabott M, Hasni Ebou M, Mint Lekweiry K, Ould Ahmedou Salem M, Ould Brahim K, et al. Mosquitoes (Diptera: Culicidae) in Mauritania: a review of their biodiversity, distribution and medical importance. Parasit Vectors. 2017;10:35 pubmed publisher
    ..Culex poicilipes and Cx. antenattus were naturally found infected with Rift valley fever virus in central and northern Mauritania following the Rift valley outbreaks of 1998 and 2012. Recently, Ae...
  13. Kakooza Mwesige A, Tshala Katumbay D, Juliano S. Viral infections of the central nervous system in Africa. Brain Res Bull. 2019;145:2-17 pubmed publisher
    ..viruses, HIV (Retroviridae) tops the list for morbidity, mortality and long term disability, while the Rift Valley Fever virus (Bunyaviridae) is at the bottom of the list...
  14. Ly H, Ikegami T. Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins. Virol J. 2016;13:118 pubmed publisher
    ..The nonstructural (NS) protein, which is a major virulence factor for Rift Valley fever virus (RVFV), is encoded on the S-segment...
  15. Ehlen L, Tödtmann J, Specht S, Kallies R, Papies J, Muller M, et al. Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses. Virol J. 2016;13:74 pubmed publisher
    ..Susceptibility to members of zoonotic Bunya-, Rhabdo-, and Flaviviridae, in particular Rift Valley fever virus (RVFV), vesicular stomatitis virus (VSV), West Nile virus (WNV), and tick-borne encephalitis virus (TBEV) ..
  16. Lathan R, Simon Chazottes D, Jouvion G, Godon O, Malissen M, Flamand M, et al. Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models. Sci Rep. 2017;7:7096 pubmed publisher
    b>Rift Valley fever virus (RVFV) leads to varied clinical manifestations in animals and in humans that range from moderate fever to fatal illness, suggesting that host immune responses are important determinants of the disease severity...
  17. O Hearn A, Voorhees M, Fetterer D, Wauquier N, Coomber M, Bangura J, et al. Serosurveillance of viral pathogens circulating in West Africa. Virol J. 2016;13:163 pubmed
    ..2 % were positive for Lassa virus, 5.2 % for Ebola virus, 10.7 % for Marburg virus, 1.8 % for Rift Valley fever virus, 2.0 % for Crimean-Congo hemorrhagic fever virus, 52.9 % for flaviviruses and 55.8 % for alphaviruses...
  18. Enkhtsetseg A, Davadoorj R, Fernandez S, Mongkolsirichaikul D, Altantuul D, Elbegdorj E, et al. Seroconversion to Causes of Febrile Illness in Mongolian Peacekeepers Deployed to South Sudan. Am J Trop Med Hyg. 2016;95:1469-1471 pubmed
    ..chikungunya virus (0), Congo-Crimean hemorrhagic fever virus (0), Japanese encephalitis virus (0), and Rift Valley fever virus (0). There was also evidence of exposure to WNV, C...
  19. de St Maurice A, Nyakarahuka L, Purpura L, Ervin E, Tumusiime A, Balinandi S, et al. Rift Valley Fever: A survey of knowledge, attitudes, and practice of slaughterhouse workers and community members in Kabale District, Uganda. PLoS Negl Trop Dis. 2018;12:e0006175 pubmed publisher
    b>Rift Valley Fever virus (RVF) is a zoonotic virus in the Phenuiviridae family. RVF outbreaks can cause significant morbidity and mortality in humans and animals...
  20. Holm T, Kopicki J, Busch C, Olschewski S, Rosenthal M, Uetrecht C, et al. Biochemical and structural studies reveal differences and commonalities among cap-snatching endonucleases from segmented negative-strand RNA viruses. J Biol Chem. 2018;293:19686-19698 pubmed publisher
    ..in the context of other cap-snatching endonucleases, such as the enzymatically active endonuclease from Rift Valley fever virus (RVFV), from Arenaviridae and Bunyavirales, belonging to the His- and His+ endonucleases, respectively, ..
  21. Laughlin R, DRAKE K, Morrill J, Adams L. Correlative Gene Expression to Protective Seroconversion in Rift Valley Fever Vaccinates. PLoS ONE. 2016;11:e0147027 pubmed publisher
    b>Rift Valley fever Virus (RVFV), a negative-stranded RNA virus, is the etiological agent of the vector-borne zoonotic disease, Rift Valley fever (RVF). In both humans and livestock, protective immunity can be achieved through vaccination...
  22. Pinkham C, An S, Lundberg L, Bansal N, Benedict A, Narayanan A, et al. The role of signal transducer and activator of transcription 3 in Rift Valley fever virus infection. Virology. 2016;496:175-185 pubmed publisher
    ..and activator of transcription 3 (STAT3) is phosphorylated on its conserved tyrosine residue (Y705) following RVFV infection. This phosphorylation was dependent on a major virulence factor, the viral nonstructural protein NSs...
  23. Mubemba B, Thompson P, Odendaal L, Coetzee P, Venter E. Evaluation of positive Rift Valley fever virus formalin-fixed paraffin embedded samples as a source of sequence data for retrospective phylogenetic analysis. J Virol Methods. 2017;243:10-14 pubmed publisher
    ..A RT-PCR assay targeting a 490?nt portion of the structural GN glycoprotein encoding gene of the RVFV M-segment was applied to total RNA extracted from archived RVFV positive FFPE samples...
  24. Eifan S, Schnettler E, Dietrich I, Kohl A, Blomström A. Non-structural proteins of arthropod-borne bunyaviruses: roles and functions. Viruses. 2013;5:2447-68 pubmed publisher
    ..The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt ..
  25. Smee D, Jung K, Westover J, Gowen B. 2'-Fluoro-2'-deoxycytidine is a broad-spectrum inhibitor of bunyaviruses in vitro and in phleboviral disease mouse models. Antiviral Res. 2018;160:48-54 pubmed publisher
    ..La Crosse (LACV), Maporal, Punta Toro, Rift Valley fever (RVFV), and San Angelo viruses were inhibited in CPE assays at 2.2-9.7 μM concentrations...
  26. Mweya C, Kimera S, Mellau L, Mboera L. Inter-epidemic abundance and distribution of potential mosquito vectors for Rift Valley fever virus in Ngorongoro district, Tanzania. Glob Health Action. 2015;8:25929 pubmed publisher
    ..aegypti, none was infected with RVF virus. These results provide insights into unique habitat characterisation relating to mosquito abundances and distribution in RVF epidemic-prone areas of Ngorongoro district in northern Tanzania. ..
  27. Filippitzi M, Goumperis T, Robinson T, Saegerman C. Microbiological Zoonotic Emerging Risks, Transmitted Between Livestock Animals and Humans (2007-2015). Transbound Emerg Dis. 2017;64:1059-1070 pubmed publisher
    ..to the criteria set, the search identified seven such zoonotic agents, namely West Nile Fever virus, Rift Valley Fever virus, Crimean-Congo Haemorrhagic Fever virus, Influenza A H1N1 virus, Coxiella burnetii, Streptococcus suis ..
  28. Swai E, Sindato C. Seroprevalence of Rift Valley fever virus infection in camels (dromedaries) in northern Tanzania. Trop Anim Health Prod. 2015;47:347-52 pubmed publisher
    ..non-vaccinated camels during the period June to August 2010 and tested for antibodies specific to RVF virus (RVFV) using the inhibition enzyme-linked immunosorbent assay (ELISA)...
  29. Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, et al. Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Res. 2018;154:174-182 pubmed publisher
    ..1 and Zika virus, as well as azacitidine, cyclosporine, minocycline, oritavancin and ritonavir against Rift valley fever virus. Thus, the spectrum of antiviral activities of existing antiviral agents could be expanded towards other ..
  30. Marcato V, Luron L, Laqueuvre L, Simon D, Mansuroglu Z, Flamand M, et al. β-Catenin Upregulates the Constitutive and Virus-Induced Transcriptional Capacity of the Interferon Beta Promoter through T-Cell Factor Binding Sites. Mol Cell Biol. 2016;36:13-29 pubmed publisher
    ..the role of β-catenin in the innate antiviral response, we show here that highly pathogenic Rift Valley fever virus (RVFV) targets the Wnt/β-catenin pathway and the formation of active TCF/β-catenin complexes at the ..
  31. Halldorsson S, Behrens A, Harlos K, Huiskonen J, Elliott R, Crispin M, et al. Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion. Proc Natl Acad Sci U S A. 2016;113:7154-9 pubmed publisher
    ..By comparison of SFTSV Gc with that of the prefusion structure of the related Rift Valley fever virus, we show that these changes involve refolding of the protein into a trimeric state...
  32. Ly H, Nishiyama S, Lokugamage N, Smith J, Zhang L, Perez D, et al. Attenuation and protective efficacy of Rift Valley fever phlebovirus rMP12-GM50 strain. Vaccine. 2017;35:6634-6642 pubmed publisher
    ..also important for live-attenuated strains to encode unique genetic markers for the differentiation from wild-type RVFV strains...
  33. Mudhasani R, Kota K, Retterer C, Tran J, Tritsch S, Zamani R, et al. High-content image-based screening of a signal transduction pathway inhibitor small-molecule library against highly pathogenic RNA viruses. J Biomol Screen. 2015;20:141-52 pubmed publisher
    ..Four compounds (E225-0969, E528-0039, G118-0778, and G544-0735), which were most active against Rift Valley fever virus (RVFV) and showed broad-spectrum antiviral activity, were selected for further evaluation for their ..
  34. Wuerth J, Weber F. Phleboviruses and the Type I Interferon Response. Viruses. 2016;8: pubmed publisher
    ..Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly fever Sicilian virus (SFSV), Toscana virus (TOSV), ..
  35. Muiruri S, Kabiru E, Muchiri E, Hussein H, Kagondu F, LaBeaud A, et al. Cross-sectional survey of Rift Valley fever virus exposure in Bodhei village located in a transitional coastal forest habitat in Lamu county, Kenya. Am J Trop Med Hyg. 2015;92:394-400 pubmed publisher
    Few studies have focused on Rift Valley fever virus (RVFV) transmission in less arid, transitional landscapes surrounding known high-risk regions...
  36. Sow A, Loucoubar C, Diallo D, Faye O, Ndiaye Y, Senghor C, et al. Concurrent malaria and arbovirus infections in Kedougou, southeastern Senegal. Malar J. 2016;15:47 pubmed publisher
    ..DENV), chikungunya (CHIKV), Crimean Congo haemorrhagic fever (CCHFV), Zika (ZIKV), and Rift Valley fever viruses (RVFV)...
  37. Bukbuk D, Fukushi S, Tani H, Yoshikawa T, Taniguchi S, Iha K, et al. Development and validation of serological assays for viral hemorrhagic fevers and determination of the prevalence of Rift Valley fever in Borno State, Nigeria. Trans R Soc Trop Med Hyg. 2014;108:768-73 pubmed publisher
    ..Recombinant nucleoprotein (rNP)-based IgG-ELISAs for the detection of serum antibodies against RVF virus (RVFV), Lassa fever virus (LASV), and Crimean-Congo hemorrhagic fever virus (CCHFV) were used to test human sera in Borno ..
  38. Brown G, Venter E, Morley P, Annandale H. The effect of Rift Valley fever virus Clone 13 vaccine on semen quality in rams. Onderstepoort J Vet Res. 2015;82:919 pubmed publisher
    ..Livestock vaccination may assist in disease control. Rift Valley fever virus (RVFV) Clone 13 is a relatively new vaccine against RVF, derived from an avirulent natural mutant strain ..
  39. Lang Y, Henningson J, Jasperson D, Li Y, Lee J, Ma J, et al. Mouse model for the Rift Valley fever virus MP12 strain infection. Vet Microbiol. 2016;195:70-77 pubmed publisher
    b>Rift Valley fever virus (RVFV), a Category A pathogen and select agent, is the causative agent of Rift Valley fever. To date, no fully licensed vaccine is available in the U.S...
  40. Ikegami T, Hill T, Smith J, Zhang L, Juelich T, Gong B, et al. Rift Valley Fever Virus MP-12 Vaccine Is Fully Attenuated by a Combination of Partial Attenuations in the S, M, and L Segments. J Virol. 2015;89:7262-76 pubmed publisher
    ..RVF is caused by Rift Valley fever virus (RVFV; family Bunyaviridae, genus Phlebovirus), which has a tripartite negative-stranded RNA genome (..
  41. Gray G, Anderson B, LaBeaud A, Heraud J, Fèvre E, Andriamandimby S, et al. Seroepidemiological Study of Interepidemic Rift Valley Fever Virus Infection Among Persons with Intense Ruminant Exposure in Madagascar and Kenya. Am J Trop Med Hyg. 2015;93:1364-70 pubmed publisher
    In this cross-sectional seroepidemiological study we sought to examine the evidence for circulation of Rift Valley fever virus (RVFV) among herders in Madagascar and Kenya...
  42. Owange N, Ogara W, Affognon H, Peter G, Kasiiti J, Okuthe S, et al. Occurrence of rift valley fever in cattle in Ijara district, Kenya. Prev Vet Med. 2014;117:121-8 pubmed publisher
    ..serum samples collected were subjected to RVF inhibition ELISA test to detect if there was exposure for RVF virus (RVFV)...
  43. Kim H, Park J, Jeoung H, Yeh J, Cho Y, Choi J, et al. Serological surveillance studies confirm the Rift Valley fever virus free status in South Korea. Trop Anim Health Prod. 2015;47:1427-30 pubmed publisher
    ..Recently, a Rift Valley fever virus (RVFV) outbreak in the Arabian Peninsula increased its potential spread to new regions worldwide...
  44. Lô M, Mbao V, Sierra P, Thiongane Y, Diop M, Donadeu M, et al. Safety and immunogenicity of Onderstepoort Biological Products' Rift Valley fever Clone 13 vaccine in sheep and goats under field conditions in Senegal. Onderstepoort J Vet Res. 2015;82:857 pubmed publisher
    ..was conducted in Senegal to assess safety and immunogenicity of administration of the registered dose of Rift Valley fever virus (RVFV) Clone 13 vaccine (Onderstepoort Biological Products) to sheep and goats of West African breeds ..
  45. Lorenzo G, López Gil E, Ortego J, Brun A. Efficacy of different DNA and MVA prime-boost vaccination regimens against a Rift Valley fever virus (RVFV) challenge in sheep 12 weeks following vaccination. Vet Res. 2018;49:21 pubmed publisher
    The aim of this work was to evaluate the immunogenicity and efficacy of DNA and MVA vaccines encoding the RVFV glycoproteins Gn and Gc in an ovine model of RVFV infection...
  46. Austin D, Baer A, Lundberg L, Shafagati N, Schoonmaker A, Narayanan A, et al. p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production. PLoS ONE. 2012;7:e36327 pubmed publisher
    b>Rift Valley fever virus (RVFV) is an emerging viral zoonosis that is responsible for devastating outbreaks among livestock and is capable of causing potentially fatal disease in humans...
  47. Mansfield K, Banyard A, McElhinney L, Johnson N, Horton D, Hernández Triana L, et al. Rift Valley fever virus: A review of diagnosis and vaccination, and implications for emergence in Europe. Vaccine. 2015;33:5520-5531 pubmed publisher
    b>Rift Valley fever virus (RVFV) is a mosquito-borne virus, and is the causative agent of Rift Valley fever (RVF), a zoonotic disease characterised by an increased incidence of abortion or foetal malformation in ruminants...
  48. Borrego B, Lorenzo G, Mota Morales J, Almanza Reyes H, Mateos F, López Gil E, et al. Potential application of silver nanoparticles to control the infectivity of Rift Valley fever virus in vitro and in vivo. Nanomedicine. 2016;12:1185-92 pubmed publisher
    ..have tested the potential antiviral activity of silver nanoparticles formulated as Argovitâ„¢ against Rift Valley fever virus (RVFV)...
  49. Wichgers Schreur P, Oreshkova N, Harders F, Bossers A, Moormann R, Kortekaas J. Paramyxovirus-based production of Rift Valley fever virus replicon particles. J Gen Virol. 2014;95:2638-48 pubmed publisher
    ..Recently, we developed Rift Valley fever virus (RVFV) replicon particles, also known as nonspreading RVFV (NSR), and demonstrated that a single ..
  50. Oreshkova N, Spel L, Vloet R, Wichgers Schreur P, Moormann R, Boes M, et al. Preliminary Evaluation of a Bunyavirus Vector for Cancer Immunotherapy. J Virol. 2015;89:9124-7 pubmed publisher
    Replicon particles of Rift Valley fever virus, referred to as nonspreading Rift Valley fever virus (NSR), are intrinsically safe and highly immunogenic...
  51. Abo El Sooud K, Hashem M, Abd Elhakim Y, Kamel G, Gab Allaha A. Effect of butylated hydroxyl toluene on the immune response of Rift Valley fever vaccine in a murine model. Int Immunopharmacol. 2018;62:165-169 pubmed publisher
    ..to examine the effect of butylated hydroxy toluene (BHT) on the immune response of Rift Valley fever vaccine (RVFV) in Swiss mice. Animals were divided into four equal groups. The first group was kept as negative control...
  52. Warimwe G, Gesharisha J, Carr B, Otieno S, Otingah K, Wright D, et al. Chimpanzee Adenovirus Vaccine Provides Multispecies Protection against Rift Valley Fever. Sci Rep. 2016;6:20617 pubmed publisher
    b>Rift Valley Fever virus (RVFV) causes recurrent outbreaks of acute life-threatening human and livestock illness in Africa and the Arabian Peninsula...
  53. Carey B, Ammosova T, Pinkham C, Lin X, Zhou W, Liotta L, et al. Protein Phosphatase 1α Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation. J Virol. 2018;92: pubmed publisher
    ..which has been implicated in the regulation of a number of viruses, including HIV-1, Ebolavirus, and Rift Valley fever virus. Catalytic subunits of PP1 (PP1α, PP1β, and PP1γ) interact with a host of regulatory subunits and ..
  54. Mudhasani R, Kota K, Retterer C, Tran J, Whitehouse C, Bavari S. High content image-based screening of a protease inhibitor library reveals compounds broadly active against Rift Valley fever virus and other highly pathogenic RNA viruses. PLoS Negl Trop Dis. 2014;8:e3095 pubmed publisher
    ..as an approach to test a protease inhibitor small molecule library for antiviral activity against Rift Valley fever virus (RVFV) and to determine their mechanism of action...
  55. Jean Jose Nepomichene T, Elissa N, Cardinale E, Boyer S. Species Diversity, Abundance, and Host Preferences of Mosquitoes (Diptera: Culicidae) in Two Different Ecotypes of Madagascar With Recent RVFV Transmission. J Med Entomol. 2015;52:962-9 pubmed publisher
    ..in either arid (Toliary II district) or humid (Mampikony district) ecotypes, each with a history of Rift Valley fever virus transmission...
  56. Ellenbecker M, Lanchy J, Lodmell J. Inhibition of Rift Valley fever virus replication and perturbation of nucleocapsid-RNA interactions by suramin. Antimicrob Agents Chemother. 2014;58:7405-15 pubmed publisher
    b>Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread...
  57. Oreshkova N, Wichgers Schreur P, Spel L, Vloet R, Moormann R, Boes M, et al. Nonspreading Rift Valley Fever Virus Infection of Human Dendritic Cells Results in Downregulation of CD83 and Full Maturation of Bystander Cells. PLoS ONE. 2015;10:e0142670 pubmed publisher
    Vaccines based on nonspreading Rift Valley fever virus (NSR) induce strong humoral and robust cellular immune responses with pronounced Th1 polarisation...
  58. Mudhasani R, Tran J, Retterer C, Kota K, Whitehouse C, Bavari S. Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase. PLoS Pathog. 2016;12:e1005437 pubmed publisher
    ..The NSs (Non-structural s) protein which is encoded by Rift Valley fever virus (RVFV) promotes early PKR proteasomal degradation through a previously undefined mechanism...
  59. Tokuda S, Do Valle T, Batista L, Simon Chazottes D, Guillemot L, Bouloy M, et al. The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice. Genes Immun. 2015;16:206-12 pubmed publisher
    The large variation in individual response to infection with Rift Valley fever virus (RVFV) suggests that host genetic determinants play a role in determining virus-induced disease outcomes. These genetic factors are still unknown...
  60. Arum S, Weldon C, Orindi B, Landmann T, Tchouassi D, Affognon H, et al. Distribution and diversity of the vectors of Rift Valley fever along the livestock movement routes in the northeastern and coastal regions of Kenya. Parasit Vectors. 2015;8:294 pubmed publisher
    ..We focused on the vectors of Rift Valley fever virus (RVFv) with the aim of understanding their ecology and how they can potentially influence the circulation ..
  61. Miller M, Bennett K, Drolet B, Lindsay R, Mecham J, Reeves W, et al. Evaluation of the Efficacy, Potential for Vector Transmission, and Duration of Immunity of MP-12, an Attenuated Rift Valley Fever Virus Vaccine Candidate, in Sheep. Clin Vaccine Immunol. 2015;22:930-7 pubmed publisher
    b>Rift Valley fever virus (RVFV) causes serious disease in ruminants and humans in Africa...
  62. Fagbo S, Coetzer J, Venter E. Seroprevalence of Rift Valley fever and lumpy skin disease in African buffalo (Syncerus caffer) in the Kruger National Park and Hluhluwe-iMfolozi Park, South Africa. J S Afr Vet Assoc. 2014;85:1075 pubmed publisher
    ..This study sought to expand the understanding of the role of buffalo in the maintenance of Rift Valley fever virus (RVFV) and lumpy skin disease virus (LSDV) by determining seroprevalence to these viruses during an inter-..
  63. Beechler B, Manore C, Reininghaus B, O NEAL D, Gorsich E, Ezenwa V, et al. Enemies and turncoats: bovine tuberculosis exposes pathogenic potential of Rift Valley fever virus in a common host, African buffalo (Syncerus caffer). Proc Biol Sci. 2015;282: pubmed publisher
  64. Danzetta M, Bruno R, Sauro F, Savini L, Calistri P. Rift Valley fever trasmission dynamics described by compartmental models. Prev Vet Med. 2016;134:197-210 pubmed publisher
    ..vectors in the most of the current RVF-free temperate countries strongly support the inclusion of RVF virus (RVFV) among the most significant emerging viral threats for public and animal health...
  65. Dente M, Riccardo F, Nacca G, Ranghiasci A, Escadafal C, Gaayeb L, et al. Strengthening Preparedness for Arbovirus Infections in Mediterranean and Black Sea Countries: A Conceptual Framework to Assess Integrated Surveillance in the Context of the One Health Strategy. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..surveillance systems for West Nile virus (WNV), chikungunya virus (CHKV), dengue virus (DENV), and Rift Valley fever virus (RVFV), which involve human, animal, entomological, and environmental sectors...
  66. Westover J, Mathis A, Taylor R, Wandersee L, Bailey K, Sefing E, et al. Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters. Antiviral Res. 2018;156:38-45 pubmed publisher
    b>Rift Valley fever virus (RVFV) is a mosquito-borne pathogen endemic to sub-Saharan Africa and the Arabian Peninsula...
  67. Mroz C, Schmidt K, Reiche S, Groschup M, Eiden M. Development of monoclonal antibodies to Rift Valley Fever Virus and their application in antigen detection and indirect immunofluorescence. J Immunol Methods. 2018;460:36-44 pubmed publisher
    b>Rift Valley fever virus is a mosquito-borne virus which is associated with acute hemorrhagic fever leading to large outbreaks among ruminants and humans in Africa and the Arabian Peninsula...
  68. Said A, Elmanzalawy M, Ma G, Damiani A, Osterrieder N. An equine herpesvirus type 1 (EHV-1) vector expressing Rift Valley fever virus (RVFV) Gn and Gc induces neutralizing antibodies in sheep. Virol J. 2017;14:154 pubmed publisher
    b>Rift Valley fever virus (RVFV) is an arthropod-borne bunyavirus that can cause serious and fatal disease in humans and animals. RVFV is a negative-sense RNA virus of the Phlebovirus genus in the Bunyaviridae family...
  69. Riblett A, Blomen V, Jae L, Altamura L, Doms R, Brummelkamp T, et al. A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection. J Virol. 2016;90:1414-23 pubmed publisher
    b>Rift Valley fever virus (RVFV) causes recurrent insect-borne epizootics throughout the African continent, and infection of humans can lead to a lethal hemorrhagic fever syndrome...
  70. Islam M, Baudin M, Eriksson J, Öberg C, Habjan M, Weber F, et al. High-Throughput Screening Using a Whole-Cell Virus Replication Reporter Gene Assay to Identify Inhibitory Compounds against Rift Valley Fever Virus Infection. J Biomol Screen. 2016;21:354-62 pubmed publisher
    b>Rift Valley fever virus (RVFV) is an emerging virus that causes serious illness in humans and livestock. There are no approved vaccines or treatments for humans...
  71. Ragan I, Davis A, Mcvey D, Richt J, Rowland R, Wilson W. Evaluation of Fluorescence Microsphere Immunoassay for Detection of Antibodies to Rift Valley Fever Virus Nucleocapsid Protein and Glycoproteins. J Clin Microbiol. 2018;56: pubmed publisher
    b>Rift Valley fever virus (RVFV) is a mosquito-borne, zoonotic virus that infects ruminants, including cattle, sheep, goats, camels, and buffalo...
  72. Nishiyama S, Lokugamage N, Ikegami T. The L, M, and S Segments of Rift Valley Fever Virus MP-12 Vaccine Independently Contribute to a Temperature-Sensitive Phenotype. J Virol. 2016;90:3735-44 pubmed publisher
    ..b>Rift Valley fever virus (RVFV; family Bunyaviridae, genus Phlebovirus) has a tripartite negative-stranded RNA genome (L, M, and S ..
  73. Monteiro G, Jansen van Vuren P, Wichgers Schreur P, Odendaal L, Clift S, Kortekaas J, et al. Mutation of adjacent cysteine residues in the NSs protein of Rift Valley fever virus results in loss of virulence in mice. Virus Res. 2018;249:31-44 pubmed publisher
    The NSs protein encoded by the S segment of Rift Valley fever virus (RVFV) is the major virulence factor, counteracting the host innate antiviral defence...
  74. Wichgers Schreur P, Kant J, Van Keulen L, Moormann R, Kortekaas J. Four-segmented Rift Valley fever virus induces sterile immunity in sheep after a single vaccination. Vaccine. 2015;33:1459-64 pubmed publisher
    b>Rift Valley fever virus (RVFV), a mosquito-borne virus in the Bunyaviridae family, causes recurrent outbreaks with severe disease in ruminants and occasionally humans...
  75. TAYLOR R, Kotian P, Warren T, Panchal R, Bavari S, Julander J, et al. BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease. J Infect Public Health. 2016;9:220-6 pubmed publisher
    ..In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, BCX4430 has demonstrated pronounced efficacy...
  76. Keck F, Amaya M, Kehn Hall K, Roberts B, Bailey C, Narayanan A. Characterizing the effect of Bortezomib on Rift Valley Fever Virus multiplication. Antiviral Res. 2015;120:48-56 pubmed publisher
    b>Rift Valley Fever Virus (RVFV) belongs to the family Bunyaviridae and is a known cause of epizootics and epidemics in Africa and the Middle East...
  77. Benedict A, Bansal N, Senina S, Hooper I, Lundberg L, de La Fuente C, et al. Repurposing FDA-approved drugs as therapeutics to treat Rift Valley fever virus infection. Front Microbiol. 2015;6:676 pubmed publisher
    There are currently no FDA-approved therapeutics available to treat Rift Valley fever virus (RVFV) infection...
  78. Busch C, Callicott R, Peters C, Morrill J, Womack J. Mapping a Major Gene for Resistance to Rift Valley Fever Virus in Laboratory Rats. J Hered. 2015;106:728-33 pubmed publisher
    The Rift Valley Fever virus (RVFV) presents an epidemic and epizootic threat in sub-Saharan Africa, Egypt, and the Arabian Peninsula, and has furthermore recently gained attention as a potential weapon of bioterrorism due to its ability ..
  79. Tantely L, Boyer S, Fontenille D. A review of mosquitoes associated with Rift Valley fever virus in Madagascar. Am J Trop Med Hyg. 2015;92:722-9 pubmed publisher
    ..The disease is caused by a Phlebovirus (RVF virus [RVFV]) transmitted to vertebrate hosts through the bite of infected mosquitoes...
  80. Baer A, Shafagati N, Benedict A, Ammosova T, Ivanov A, Hakami R, et al. Protein Phosphatase-1 regulates Rift Valley fever virus replication. Antiviral Res. 2016;127:79-89 pubmed publisher
    b>Rift Valley fever virus (RVFV), genus Phlebovirus family Bunyaviridae, is an arthropod-borne virus endemic throughout sub-Saharan Africa...
  81. Sadeuh Mba S, Yonga Wansi G, Demanou M, Gessain A, Njouom R. Serological evidence of rift valley fever Phlebovirus and Crimean-Congo hemorrhagic fever orthonairovirus infections among pygmies in the east region of Cameroon. Virol J. 2018;15:63 pubmed publisher
    Rift Valley Fever Phlebovirus (RVFV) and Crimean-Congo Hemorrhagic Fever Orthonairovirus (CCHFV) specific antibodies had been documented among humans in urban settings of the southwestern and northern Cameroon in the late 1980s...
  82. Wu Y, Zhu Y, Gao F, Jiao Y, Oladejo B, Chai Y, et al. Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope. Proc Natl Acad Sci U S A. 2017;114:E7564-E7573 pubmed publisher
    Severe fever with thrombocytopenia syndrome virus (SFTSV) and Rift Valley fever virus (RVFV) are two arthropod-borne phleboviruses in the Bunyaviridae family, which cause severe illness in humans and animals...
  83. Copeland A, Altamura L, Van Deusen N, Schmaljohn C. Nuclear relocalization of polyadenylate binding protein during rift valley fever virus infection involves expression of the NSs gene. J Virol. 2013;87:11659-69 pubmed publisher
    b>Rift Valley fever virus (RVFV), an ambisense member of the family Bunyaviridae, genus Phlebovirus, is the causative agent of Rift Valley fever, an important zoonotic infection in Africa and the Middle East...
  84. Hopkins K, Tartell M, Herrmann C, Hackett B, Taschuk F, Panda D, et al. Virus-induced translational arrest through 4EBP1/2-dependent decay of 5'-TOP mRNAs restricts viral infection. Proc Natl Acad Sci U S A. 2015;112:E2920-9 pubmed publisher
    The mosquito-transmitted bunyavirus, Rift Valley fever virus (RVFV), is a highly successful pathogen for which there are no vaccines or therapeutics. Translational arrest is a common antiviral strategy used by hosts...
  85. Ellenbecker M, St Goddard J, Sundet A, Lanchy J, Raiford D, Lodmell J. Computational prediction and biochemical characterization of novel RNA aptamers to Rift Valley fever virus nucleocapsid protein. Comput Biol Chem. 2015;58:120-5 pubmed publisher
    b>Rift Valley fever virus (RVFV) is a potent human and livestock pathogen endemic to sub-Saharan Africa and the Arabian Peninsula that has potential to spread to other parts of the world...
  86. Mweya C, Kimera S, Karimuribo E, Mboera L. Comparison of sampling techniques for Rift Valley Fever virus potential vectors, Aedes aegypti and Culex pipiens complex, in Ngorongoro District in northern Tanzania. Tanzan J Health Res. 2013;15:158-64 pubmed
    ..techniques with two types of traps and attractants at different time for trapping potential vectors for Rift Valley Fever virus. The study was conducted in six villages in Ngorongoro district in Tanzania from September to October ..
  87. Ndiaye E, Fall G, Gaye A, Bob N, Talla C, Diagne C, et al. Vector competence of Aedes vexans (Meigen), Culex poicilipes (Theobald) and Cx. quinquefasciatus Say from Senegal for West and East African lineages of Rift Valley fever virus. Parasit Vectors. 2016;9:94 pubmed publisher
    b>Rift Valley fever virus (RVFV; Phlebovirus, Bunyaviridae) is a mosquito-borne, zoonotic pathogen. In Senegal, RVFV was first isolated in 1974 from Aedes dalzieli (Theobald) and thereafter from Ae. fowleri (de Charmoy), Ae...
  88. Turell M, Britch S, Aldridge R, Xue R, Smith M, Cohnstaedt L, et al. Potential for Psorophora columbiae and Psorophora ciliata Mosquitoes (Diptera: Culicidae) to Transmit Rift Valley Fever Virus. J Med Entomol. 2015;52:1111-6 pubmed publisher
    b>Rift Valley fever virus (RVFV) continues to pose a threat to much of the world...
  89. Mroz C, Gwida M, El Ashker M, El Diasty M, El Beskawy M, Ziegler U, et al. Seroprevalence of Rift Valley fever virus in livestock during inter-epidemic period in Egypt, 2014/15. BMC Vet Res. 2017;13:87 pubmed publisher
    b>Rift Valley fever virus (RVFV) caused several outbreaks throughout the African continent and the Arabian Peninsula posing significant threat to human and animal health...
  90. Terasaki K, Tercero B, Makino S. Single-cycle replicable Rift Valley fever virus mutants as safe vaccine candidates. Virus Res. 2016;216:55-65 pubmed publisher
    b>Rift Valley fever virus (RVFV) is an arbovirus circulating between ruminants and mosquitoes to maintain its enzootic cycle. Humans are infected with RVFV through mosquito bites or direct contact with materials of infected animals...
  91. Bell T, Espina V, Lundberg L, Pinkham C, Brahms A, Carey B, et al. Combination Kinase Inhibitor Treatment Suppresses Rift Valley Fever Virus Replication. Viruses. 2018;10: pubmed publisher
    ..involved in translation, including p70 S6K, p90RSK, ERK, and p38 MAPK, are phosphorylated following Rift Valley fever virus (RVFV) infection...
  92. Lancelot R, Beral M, Rakotoharinome V, Andriamandimby S, Heraud J, Coste C, et al. Drivers of Rift Valley fever epidemics in Madagascar. Proc Natl Acad Sci U S A. 2017;114:938-943 pubmed publisher
    ..contrast to East Africa, environmental drivers did not trigger the epidemics: They only modulated local Rift Valley fever virus (RVFV) transmission in ruminants...