Gumboro virus

Summary

Alias: Infectious bursal disease virus, Avian infectious bursal disease virus, Infectious bursal disease virus of chickens, infectious bursal disease virus IBDV, IBDV

Top Publications

  1. Li Z, Wang Y, Li X, Li X, Cao H, Zheng S. Critical roles of glucocorticoid-induced leucine zipper in infectious bursal disease virus (IBDV)-induced suppression of type I Interferon expression and enhancement of IBDV growth in host cells via interaction with VP4. J Virol. 2013;87:1221-31 pubmed publisher
    ..bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV)...
  2. Maartens L, Joubert H, Aitchison H, Venter E. Inclusion body hepatitis associated with an outbreak of fowl adenovirus type 2 and type 8b in broiler flocks in South Africa. J S Afr Vet Assoc. 2014;85:e1-5 pubmed publisher
    ..Two infectious bursal disease virus isolates were also made from the Klerksdorp flock...
  3. Zhao Y, Cheng G, Hao H, Pan Y, Liu Z, Dai M, et al. In vitro antimicrobial activities of animal-used quinoxaline 1,4-di-N-oxides against mycobacteria, mycoplasma and fungi. BMC Vet Res. 2016;12:186 pubmed publisher
    ..75. These compounds were also submitted to antiviral assay against infectious bursal disease virus, porcine reproductive and respiratory syndrome virus, porcine parvovirus and classical swine fever ..
  4. Brown Jordan A, Bolfa P, Marchi S, Hemmings S, Major T, Suepaul R, et al. Detection of Antibodies to Seven Priority Pathogens in Backyard Poultry in Trinidad, West Indies. Vet Sci. 2018;5: pubmed publisher
    ..5% (CI 95%: 52-80%) for Infectious bursal disease virus (IBDV), 10% (CI 95%: 4-23%) for Newcastle disease virus (NDV), 0% (CI 95%: 0-0%) for Avian influenza ..
  5. Aizenshtein E, Yosipovich R, Kvint M, Shadmon R, Krispel S, Shuster E, et al. Practical aspects in the use of passive immunization as an alternative to attenuated viral vaccines. Vaccine. 2016;34:2513-8 pubmed publisher
    ..Following injection of 1-day-old broilers with antibodies against infectious bursal disease virus, protective antibody levels were acquired for the entire period of sensitivity to this pathogen (35 ..
  6. Parsons N, Gous T, Schaefer A, Vanstreels R. Health evaluation of African penguins (<i>Spheniscus demersus</i>) in southern Africa. Onderstepoort J Vet Res. 2016;83:e1-e13 pubmed publisher
    ..pathogens tested: avian encephalomyelitis virus, avian infectious bronchitis virus, avian reovirus, infectious bursal disease virus, Newcastle disease virus, Mycoplasma gallisepticum and Mycoplasma synoviae...
  7. Kjærup R, Juul Madsen H, Norup L, Sørensen P, Dalgaard T. Comparison of growth performance and immune parameters of three commercial chicken lines used in organic production. Vet Immunol Immunopathol. 2017;187:69-79 pubmed publisher
    ..response were observed in the Bovans at week 5, corresponding to 1 week after vaccination with live infectious bursal disease virus. With regard to adaptive immune parameters such as IgY concentration in blood and infectious bursal ..
  8. Zhang W, Zuo E, He Y, Chen D, Long X, Chen M, et al. Promoter structures and differential responses to viral and non-viral inducers of chicken melanoma differentiation-associated gene 5. Mol Immunol. 2016;76:1-6 pubmed publisher
    ..cells were stimulated with polyinosinic: polycytidylic acid (poly I:C), interferon beta (IFN-?) or Infectious Bursal Disease Virus (IBDV)...
  9. Owolodun O, Yakubu B, Jambol A, Audu B, Dogonyaro B, Luka P. Further evidence for very virulent infectious bursal disease virus in vaccinated chickens in Nigeria. Trop Anim Health Prod. 2015;47:1437-41 pubmed publisher
    ..Nucleotide sequencing and analysis of the four samples revealed high similarity to previous IBDV sequences from northern and southern Nigeria...

More Information

Publications158 found, 100 shown here

  1. Trinh D, Ogawa H, Bui V, Nguyen T, Gronsang D, Baatartsogt T, et al. Development of a blocking latex agglutination test for the detection of antibodies to chicken anemia virus. J Virol Methods. 2015;221:74-80 pubmed publisher
    ..chickens and sera containing antibodies to avian influenza virus, Newcastle disease virus, infectious bursal disease virus, and Marek's disease virus; nonspecific agglutination and cross-reactivity with antibodies to ..
  2. Jaganathan S, Ooi P, Phang L, Allaudin Z, Yip L, Choo P, et al. Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle Disease Virus outbreak in West Malaysia. BMC Vet Res. 2015;11:219 pubmed publisher
    ..All farms were concurrently positive with two immunosuppressive viruses; Infectious Bursal Disease Virus (IBDV) and Marek's Disease Virus (MDV)...
  3. Fellahi S, El Harrak M, Kuhn J, Sebbar G, Bouaiti E, Khataby K, et al. Comparison of SYBR green I real-time RT-PCR with conventional agarose gel-based RT-PCR for the diagnosis of infectious bronchitis virus infection in chickens in Morocco. BMC Res Notes. 2016;9:231 pubmed publisher
    ..All negative controls, such as Newcastle disease virus, infectious bursal disease virus, and avian influenza virus, were not detected...
  4. Ding M, Yang X, Wang H, Zhang A, Zhang Z, Fan W, et al. Development of an ELISA based on a multi-fragment antigen of infectious bronchitis virus for antibodies detection. Biotechnol Lett. 2015;37:2453-9 pubmed publisher
    ..the coated antigen BE and antiserum against newcastle disease virus, avian influenza virus, or infectious bursal disease virus was observed. The performance of BE-ELISA was evaluated, and showed 95...
  5. Giotis E, Ross C, Robey R, Nohturfft A, Goodbourn S, Skinner M. Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells. Sci Rep. 2017;7:17485 pubmed publisher
    ..under both normal and stimulated conditions using chicken interferon-? (chIFN-?) and the attenuated infectious bursal disease virus vaccine strain PBG98. We found that DF-1 have an attenuated innate response compared to CEFs...
  6. Brown Jordan A, Gongora V, Hartley D, Oura C. A Review of Eight High-Priority, Economically Important Viral Pathogens of Poultry within the Caribbean Region. Vet Sci. 2018;5: pubmed publisher
    ..disease virus (NDV), infectious laryngotracheitis virus (ILTV), avian metapneumovirus (aMPV), infectious bursal disease virus (IBDV), fowl adenovirus group 1 (FADV Gp1), and egg drop syndrome virus (EDSV) were selected for ..
  7. Tenje M, Xia H, Evander M, Hammarström B, Tojo A, Belák S, et al. Acoustic trapping as a generic non-contact incubation site for multiplex bead-based assays. Anal Chim Acta. 2015;853:682-8 pubmed publisher
    ..The Luminex assay is designed for detecting antibodies in poultry serum for infectious bursal disease virus, infectious bronchitis virus, Newcastle disease virus and avian reovirus...
  8. Kasanga C, Yamaguchi T, Munang andu H, Ohya K, Fukushi H. Molecular epidemiology of infectious bursal disease virus in Zambia. J S Afr Vet Assoc. 2013;84:E1-4 pubmed publisher
    ..These findings represent the first documentation of the existence of the African VV-IBDV variants in both indigenous and exotic chickens in Zambia.
  9. Jeon W, Lee H, Roh I, Yoon Y, Kim J, Choi K. Effect of maternally derived antibody on sequential infection with highly virulent bursal disease virus in newly hatched broilers. Poult Sci. 2017;: pubmed publisher
    Maternally derived antibodies (MDAs) are important for protection against very virulent infectious bursal disease virus (vvIBDV)...
  10. Saito E, Shea S, Jones A, Ramos G, Pitesky M. A cooperative approach to animal disease response activities: Analytical hierarchy process (AHP) and vvIBD in California poultry. Prev Vet Med. 2015;121:123-31 pubmed publisher
    Very virulent infectious bursal disease virus (vvIBDv) was first detected in the United States at the end of 2008...
  11. Ciccone N, Mwangi W, Ruzov A, Smith L, Butter C, Nair V. A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxymethylcytosine levels. Vet Res. 2014;45:108 pubmed publisher
    ..Moreover, our data revealed that infectious bursal disease virus (IBDV) disrupts this genomic methylation pattern causing a global increase in 5hmC levels in a ..
  12. Liu X, Shan W, Xu S, Zhang J, Xu F, Xia S, et al. The efficacy of chimeric vaccines constructed with PEP-1 and Ii-Key linking to a hybrid epitope from heterologous viruses. Biologicals. 2015;43:377-82 pubmed publisher
    ..peptide chimeras, we linked the two vehicles to hybrid epitopes on the VP2 protein (aa197-209) of the infectious bursal disease virus and HN protein (aa345-353) of the Newcastle disease virus...
  13. Shabbir M, Ali M, Abbas M, Chaudhry U, Zia ur Rehman -, Munir M. Molecular characterization of infectious bursal disease viruses from Pakistan. Arch Virol. 2016;161:2001-6 pubmed publisher
    ..Here, we sequenced the hypervariable region (HVR) of the VP2 gene of circulating strains of infectious bursal disease virus (IBDV) originating from outbreaks (n = 4) in broiler flocks in Pakistan...
  14. Desingu P, Singh S, Dhama K, Kumar O, Singh R, Singh R. Development of slide ELISA (SELISA) for detection of four poultry viral pathogens by direct heat fixation of viruses on glass slides. J Virol Methods. 2014;209:76-81 pubmed publisher
    ..Newcastle disease virus (NDV), infectious bronchitis virus (IBV), infectious bursal disease virus (IBDV) and egg drop syndrome 76 virus (EDS 76) and the use of SELISA for semi quantitation of NDV are ..
  15. Stelzner J, Behrens M, Behrens S, Mäder K. Squalene containing solid lipid nanoparticles, a promising adjuvant system for yeast vaccines. Vaccine. 2018;36:2314-2320 pubmed publisher
    ..nanoemulsion in a vaccine trial in the mouse model with a yeast-based vaccine directed against the infectious bursal disease virus. All squalene-based adjuvants showed excellent biocompatibility and provided immune stimulating ..
  16. Farhanah M, Yasmin A, Mat Isa N, Hair Bejo M, Ideris A, Powers C, et al. Bursal transcriptome profiling of different inbred chicken lines reveals key differentially expressed genes at 3 days post-infection with very virulent infectious bursal disease virus. J Gen Virol. 2017;: pubmed publisher
    ..immune response genes of inbred chickens with different genetic backgrounds, following very virulent infectious bursal disease virus (vvIBDV) infection are poorly characterized...
  17. Chen Y, Hsueh Y, Hsieh C, Tzou D, Chang P. Antiviral Activity of Graphene-Silver Nanocomposites against Non-Enveloped and Enveloped Viruses. Int J Environ Res Public Health. 2016;13:430 pubmed publisher
    ..GO-Ag) against enveloped and non-enveloped viruses, feline coronavirus (FCoV) with an envelope and infectious bursal disease virus (IBDV) without an envelope were chosen...
  18. Qin Y, Zheng S. Infectious Bursal Disease Virus-Host Interactions: Multifunctional Viral Proteins that Perform Multiple and Differing Jobs. Int J Mol Sci. 2017;18: pubmed publisher
    ..bursal disease (IBD) is an acute, highly contagious and immunosuppressive poultry disease caused by IBD virus (IBDV)...
  19. Lawal N, Hair Bejo M, Arshad S, Omar A, Ideris A. Adaptation and Molecular Characterization of Two Malaysian Very Virulent Infectious Bursal Disease Virus Isolates Adapted in BGM-70 Cell Line. Adv Virol. 2017;2017:8359047 pubmed publisher
    Two Malaysian very virulent infectious bursal disease virus (vvIBDV) strains UPM0081 and UPM190 (also known as UPMB00/81 and UPM04/190, respectively) isolated from local IBD outbreaks were serially passaged 12 times (EP12) in specific ..
  20. Wang B, Duan X, Fu M, Liu Y, Wang Y, Li X, et al. The association of ribosomal protein L18 (RPL18) with infectious bursal disease virus viral protein VP3 enhances viral replication. Virus Res. 2018;245:69-79 pubmed publisher
    ..bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). IBDV VP3 is a multifunctional protein playing a key role in virus assembly and pathogenesis...
  21. Zeng T, Xie Z, Xie L, Deng X, Xie Z, Luo S, et al. Simultaneous detection of eight immunosuppressive chicken viruses using a GeXP analyser-based multiplex PCR assay. Virol J. 2015;12:226 pubmed publisher
    ..virus (MDV), three subgroups of avian leucosis virus (ALV-A/B/J), reticuloendotheliosis virus (REV), infectious bursal disease virus (IBDV), chicken infectious anaemia virus (CIAV) and avian reovirus (ARV), were amplified and ..
  22. Kumar D, Chauhan T, Agarwal R, Dhama K, Goswami P, Mariappan A, et al. A double-stranded probe coupled with isothermal amplification for qualitative and quantitative detection of avian reovirus. Arch Virol. 2017;162:979-985 pubmed publisher
    ..or bacteria present in clinical or artificially spiked samples, including Newcastle disease virus, infectious bursal disease virus, fowl adenovirus, Marek's disease virus, Escherichia coli, and Salmonella spp...
  23. Jackwood D. Advances in vaccine research against economically important viral diseases of food animals: Infectious bursal disease virus. Vet Microbiol. 2017;206:121-125 pubmed publisher
    Numerous reviews have been published on infectious bursal disease (IBD) and infectious bursal disease virus (IBDV)...
  24. Pascual E, Mata C, Gómez Blanco J, Moreno N, Bárcena J, Blanco E, et al. Structural basis for the development of avian virus capsids that display influenza virus proteins and induce protective immunity. J Virol. 2015;89:2563-74 pubmed publisher
    ..We report here that the capsid of a major avian pathogen, infectious bursal disease virus (IBDV), can accommodate heterologous proteins to induce protective immunity...
  25. Sultankulova K, Kozhabergenov N, Strochkov V, Burashev Y, Shorayeva K, Chervyakova O, et al. New oligonucleotide microarray for rapid diagnosis of avian viral diseases. Virol J. 2017;14:69 pubmed publisher
    ..avian influenza virus (AIV), Newcastle disease virus (NDV), infection bronchitis virus (IBV), and infectious bursal disease virus (IBDV) in single- and mixed-virus infections...
  26. Mata C, Mertens J, Fontana J, Luque D, Allende Ballestero C, Reguera D, et al. The RNA-binding protein of a double-stranded RNA virus acts like a scaffold protein. J Virol. 2018;: pubmed publisher
    b>Infectious bursal disease virus (IBDV), a non-enveloped, double-stranded (ds)RNA virus with a T=13 icosahedral capsid, has a virion assembly strategy that initiates with a precursor particle based on an internal scaffold shell similar to ..
  27. Rasoli M, Yeap S, Tan S, Roohani K, Kristeen Teo Y, Alitheen N, et al. Differential modulation of immune response and cytokine profiles in the bursae and spleen of chickens infected with very virulent infectious bursal disease virus. BMC Vet Res. 2015;11:75 pubmed publisher
    Very virulent infectious bursal disease virus (vvIBDV) induces immunosuppression and inflammation in young birds, which subsequently leads to high mortality...
  28. Tomás G, Hernández M, Marandino A, Hernández D, Techera C, Grecco S, et al. Genome Sequence of a Distinct Infectious Bursal Disease Virus. Genome Announc. 2015;3: pubmed publisher
    b>Infectious bursal disease virus is a relevant avian pathogen that affects poultry production. Here, we report the full-length coding sequence of the Uruguayan strain dIBDV/UY/2014/2202, isolated from a commercial broiler flock...
  29. Luan H, Wang Y, Li Y, Cui Z, Chang S, Zhao P. Development of a real-time quantitative RT-PCR to detect REV contamination in live vaccine. Poult Sci. 2016;95:2023-9 pubmed publisher
    ..no amplification signals were obtained when we attempted to detect DNA or cDNA of ALV-A/B/J, MDV, CIAV, IBDV, ARV, NDV, AIV, or other viruses, suggesting a high specificity for our method...
  30. Ou C, Wang Q, Zhang Y, Kong W, Zhang S, Yu Y, et al. Transcription profiles of the responses of chicken bursae of Fabricius to IBDV in different timing phases. Virol J. 2017;14:93 pubmed publisher
    b>Infectious bursal disease virus (IBDV) infection causes immunosuppression in chickens and increases their susceptibility to secondary infections...
  31. He X, Xiong Z, Yang L, Guan D, Yang X, Wei P. Molecular epidemiology studies on partial sequences of both genome segments reveal that reassortant infectious bursal disease viruses were dominantly prevalent in southern China during 2000-2012. Arch Virol. 2014;159:3279-92 pubmed publisher
    ..prevailed in southern China, three of which were shown to be dominant: segment A from vvIBDV and B from attenuated IBDV, segment A of vvIBDV and B from 002-73-like IBDV, and segment A of vvIBDV and B from HLJ0504 or a similar strain...
  32. Li K, Courtillon C, Guionie O, Allée C, Amelot M, Qi X, et al. Genetic, antigenic and pathogenic characterization of four infectious bursal disease virus isolates from China suggests continued evolution of very virulent viruses. Infect Genet Evol. 2015;30:120-7 pubmed publisher
    b>Infectious bursal disease virus (IBDV) causes an economically significant disease of young chickens worldwide...
  33. Deb R, Dey S, Madhan Mohan C, Gaikwad S, Kamble N, Khulape S, et al. Development and evaluation of a Salmonella typhimurium flagellin based chimeric DNA vaccine against infectious bursal disease of poultry. Res Vet Sci. 2015;102:7-14 pubmed publisher
    ..Salmonella flagellin could enhance the immune responses and protection efficacy of a DNA vaccine candidate against IBDV infection in chickens, highlighting the potential of flagellin as a genetic adjuvant in the prevention of vvIBDV ..
  34. Yu X, Rui L, Shao Q, Liu H, Lu Y, Zhang Y, et al. Changes of CD4+CD25+ cells ratio in immune organs from chickens challenged with infectious bursal disease virus strains with varying virulences. Viruses. 2015;7:1357-72 pubmed publisher
    In the current study, we investigate changes in CD4+CD25+ cells in chickens during infectious bursal disease virus (IBDV) infection. The percentage of CD4+CD25+ cells in lymph organs, e.g...
  35. Xu M, Lin S, Zhao Y, Jin J, Tang N, Zhang G. Characteristics of very virulent infectious bursal disease viruses isolated from Chinese broiler chickens (2012-2013). Acta Trop. 2015;141:128-34 pubmed publisher
    ..Phylogenetic analysis revealed that the nine broiler IBDV isolates are closely related to very virulent IBDV (vvIBDV) strains...
  36. Zhao S, Jia Y, Han D, Ma H, Shah S, Ma Y, et al. Influence of the structural development of bursa on the susceptibility of chickens to infectious bursal disease virus. Poult Sci. 2016;95:2786-2794 pubmed
    Infectious bursal disease (IBD), caused by IBD virus (IBDV), is an acute, highly contagious immunosuppressive avian disease...
  37. Qi X, Gao X, Lu Z, Zhang L, Wang Y, Gao L, et al. A single mutation in the PBC loop of VP2 is involved in the in vitro replication of infectious bursal disease virus. Sci China Life Sci. 2016;59:717-23 pubmed publisher
    ..amino acid mutations in the PBC and PHI loops of VP2 are involved in the replication and virulence of infectious bursal disease virus (IBDV), a pair of viruses, namely the moderately virulent IBDV (rGx-F9VP2) and the attenuated strain (..
  38. Lin W, Zhang Z, Xu Z, Wang B, Li X, Cao H, et al. The association of receptor of activated protein kinase C 1(RACK1) with infectious bursal disease virus viral protein VP5 and voltage-dependent anion channel 2 (VDAC2) inhibits apoptosis and enhances viral replication. J Biol Chem. 2015;290:8500-10 pubmed publisher
    ..bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV)...
  39. Morla S, Deka P, Kumar S. Isolation of novel variants of infectious bursal disease virus from different outbreaks in Northeast India. Microb Pathog. 2016;93:131-6 pubmed publisher
    b>Infectious bursal disease virus (IBDV) is a highly infectious disease of young chicken that predominantly affects the immune system...
  40. Fu M, Wang B, Chen X, He Z, Wang Y, Li X, et al. gga-miR-454 suppresses infectious bursal disease virus (IBDV) replication via directly targeting IBDV genomic segment B and cellular Suppressors of Cytokine Signaling 6 (SOCS6). Virus Res. 2018;: pubmed publisher
    ..However, the role of miRNAs in host response against infectious bursal disease virus (IBDV) infection is still unclear...
  41. Cubas Gaona L, Diaz Beneitez E, Ciscar M, Rodriguez J, Rodriguez D. Exacerbated Apoptosis of Cells Infected with Infectious Bursal Disease Virus upon Exposure to Interferon Alpha. J Virol. 2018;92: pubmed publisher
    b>Infectious bursal disease virus (IBDV) belongs to the Birnaviridae family and is the etiological agent of a highly contagious and immunosuppressive disease (IBD) that affects domestic chickens (Gallus gallus)...
  42. Jahromi M, Bello M, Abdolmaleki M, Yeap S, Hair Bejo M, Omar A. Differential activation of intraepithelial lymphocyte-natural killer cells in chickens infected with very virulent and vaccine strains of infectious bursal disease virus. Dev Comp Immunol. 2018;87:116-123 pubmed publisher
    ..4+IEL-NK) cells during infectious bursal disease virus (IBDV) infection, characterisation of the cells was performed following infection with different ..
  43. Farhanah M, Yasmin A, Khanh N, Yeap S, Hair Bejo M, Omar A. Bursal immunopathology responses of specific-pathogen-free chickens and red jungle fowl infected with very virulent infectious bursal disease virus. Arch Virol. 2018;163:2085-2097 pubmed publisher
    Very virulent infectious bursal disease virus (vvIBDV) targets B lymphocytes in the bursa of Fabricius (BF), causing immunosuppression and increased mortality rates in young birds...
  44. Silva J, Arenhart S, Santos H, Almeida Queiroz S, Silva A, Trevisol I, et al. Efficient assembly of full-length infectious clone of Brazilian IBDV isolate by homologous recombination in yeast. Braz J Microbiol. 2014;45:1555-63 pubmed
    The Infectious Bursal Disease Virus (IBDV) causes immunosuppression in young chickens. Advances in molecular virology and vaccines for IBDV have been achieved by viral reverse genetics (VRG)...
  45. Ouyang W, Wang Y, Du X, Liu H, Zhang H. gga-miR-9* inhibits IFN production in antiviral innate immunity by targeting interferon regulatory factor 2 to promote IBDV replication. Vet Microbiol. 2015;178:41-9 pubmed publisher
    ..gga-miR-9*, were markedly upregulated in specific-pathogen-free (SPF) chickens upon infection with infectious bursal disease virus (IBDV); however, the biological function of gga-miR-9* during viral infection remains unknown...
  46. Ren X, Zhang L, Gao Y, Gao H, Wang Y, Liu C, et al. Binding chicken Anx2 is beneficial for infection with infectious bursal disease virus. Virus Res. 2015;210:232-40 pubmed publisher
    b>Infectious bursal disease virus (IBDV) causes a highly contagious disease in young chickens and leads to significant economic loss in the poultry industry...
  47. Qi X, Wang Y, Gao L, Gao H, Gao Y, Wang X. [Development and Application of the Reverse Genetic Technologies for Infectious Bursal Disease Virus]. Bing Du Xue Bao. 2015;31:326-31 pubmed
    b>Infectious bursal disease virus (IBDV) is an important member of the Birnaviridae family. IBUV mainly targets the bursa of Fabricius, the central immune organ of chicken, resulting in chicken infectious bursal disease (IBD)...
  48. Mosley Y, Wu C, Lin T. IBDV particles packaged with only segment A dsRNA. Virology. 2016;488:68-72 pubmed publisher
    ..By applying a reverse genetic technique, we generated IBDV particles packaged with only segment A by co-transfection DF-1 cells of cDNA from segment A and VP1 (without 5' and ..
  49. Priyadharsini C, Senthilkumar T, Raja P, Kumanan K. Genotypic characterization of Indian isolates of infectious bursal disease virus strains by reverse transcription-polymerase chain reaction combined with restriction fragment length polymorphism analysis. Acta Virol. 2016;60:34-40 pubmed
    ..for the differentiation of classical virulent (cv), virulent (v) and very virulent (vv) strains of infectious bursal disease virus (IBDV) isolates from chicken bursal tissues in southern states of India...
  50. Jiang D, Liu Y, Wang A, Zhang G, Yang G, Chen Y, et al. High level soluble expression and one-step purification of IBDV VP2 protein in Escherichia coli. Biotechnol Lett. 2016;38:901-8 pubmed publisher
    To improve the expression of soluble IBDV VP2 protein by using different tagged vectors in Escherichia coli. Fusion tags, Grifin, MBP, SUMO, thioredoxin, ?-crystallin, ArsC and PpiB, enhanced the expression and solubility of VP2 protein...
  51. Mosley Y, Wu C, Lin T. Infectious bursal disease virus as a replication-incompetent viral vector expressing green fluorescent protein. Arch Virol. 2017;162:23-32 pubmed publisher
    b>Infectious bursal disease virus (IBDV) has been established as a replication-competent viral vector capable of carrying an epitope at multiple loci in the genome...
  52. Guo Q, Shao Q, Xu W, Rui L, Sumi R, Eguchi F, et al. Immunomodulatory and Anti-IBDV Activities of the Polysaccharide AEX from Coccomyxa gloeobotrydiformis. Mar Drugs. 2017;15: pubmed publisher
    ..the function of AEX in regulating the immune response in chickens and its capacity to inhibit the infectious bursal disease virus (IBDV), to gain an understanding of its immunomodulatory and antiviral ability...
  53. Tang N, Zhang Y, Pedrera M, Chang P, Baigent S, Moffat K, et al. A simple and rapid approach to develop recombinant avian herpesvirus vectored vaccines using CRISPR/Cas9 system. Vaccine. 2018;36:716-722 pubmed publisher
    ..genome editing as a rapid and efficient method of generating HVT recombinants expressing VP2 protein of IBDV. This approach offers an efficient method to introduce other viral antigens into the HVT genome for rapid ..
  54. Alkie T, Rautenschlein S. Infectious bursal disease virus in poultry: current status and future prospects. Vet Med (Auckl). 2016;7:9-18 pubmed publisher
    b>Infectious bursal disease virus (IBDV) affects immature B lymphocytes of the bursa of Fabricius and may cause significant immunosuppression. It continues to be a leading cause of economic losses in the poultry industry...
  55. Escaffre O, Le Nouen C, Amelot M, AMBROGGIO X, Ogden K, Guionie O, et al. Both genome segments contribute to the pathogenicity of very virulent infectious bursal disease virus. J Virol. 2013;87:2767-80 pubmed publisher
    b>Infectious bursal disease virus (IBDV) causes an economically significant disease of chickens worldwide. Very virulent IBDV (vvIBDV) strains have emerged and induce as much as 60% mortality...
  56. Xu W, Shao Q, Zang Y, Guo Q, Zhang Y, Li Z. Pigeon RIG-I Function in Innate Immunity against H9N2 IAV and IBDV. Viruses. 2015;7:4131-51 pubmed publisher
    ..receptor (PRR), can sense various RNA viruses, including the avian influenza virus (AIV) and infectious bursal disease virus (IBDV), and trigger the innate immune response...
  57. Lee C, Wu C, Lin T. Role of chicken melanoma differentiation-associated gene 5 in induction and activation of innate and adaptive immune responses to infectious bursal disease virus in cultured macrophages. Arch Virol. 2015;160:3021-35 pubmed publisher
    ..present study was to determine if chicken melanoma-differentiation-associated gene 5 (MDA5) senses infectious bursal disease virus infection to induce innate immunity that bridges to adaptive immunity...
  58. Islam M, Oomah D, Diarra M. Potential immunomodulatory effects of non-dialyzable materials of cranberry extract in poultry production. Poult Sci. 2017;96:341-350 pubmed publisher
    ..Seven-d-old chicks were vaccinated with the infectious bursal disease virus (IBDV) vaccine S-706, and treated orally with 0, 2, 4, or 8 mg/mL/bird NDMs for five consecutive days...
  59. Li K, Liu Y, Liu C, Gao L, Zhang Y, Gao Y, et al. Effects of different promoters on the protective efficacy of recombinant Marek's disease virus type 1 expressing the VP2 gene of infectious bursal disease virus. Vaccine. 2016;34:5744-5750 pubmed publisher
    ..study, two recombinant Marek's disease virus type 1 (MDV1) vaccines containing the VP2 gene of infectious bursal disease virus (IBDV) under control of different promoters were generated from overlapping fosmid DNAs...
  60. Song H, Bae Y, Park S, Kwon H, Lee H, Joh S. Loop-mediated isothermal amplification assay for detection of four immunosuppressive viruses in chicken. J Virol Methods. 2018;256:6-11 pubmed publisher
    ..virus (REV), and Marek's disease virus (MDV), and a reverse transcription (RT)-LAMP assay to detect infectious bursal disease virus (IBDV), were developed...
  61. Thammakarn C, Ishida Y, Suguro A, Hakim H, Nakajima K, Kitazawa M, et al. Inhibition of infectious bursal disease virus transmission using bioceramic derived from chicken feces. Virus Res. 2015;204:6-12 pubmed publisher
    ..its efficacy to inactivate virus and inhibit virus horizontal transmission by fecal-oral route, using infectious bursal disease virus (IBDV) vaccine strain D78 as a challenge virus...
  62. Ingrao F, Rauw F, Steensels M, van den Berg T, Lambrecht B. Early immune responses and profiling of cell-mediated immunity-associated gene expression in response to rHVT-IBD vaccination. Vaccine. 2018;36:615-623 pubmed publisher
    ..To further investigate the IBD virus (IBDV)-specific responses triggered by rHVT-IBD vaccination, vaccinated chickens were inoculated with an attenuated IBDV ..
  63. Chen G, He X, Yang L, Wei P. Antigenicity characterization of four representative natural reassortment IBDVs isolated from commercial three-yellow chickens from Southern China reveals different subtypes co-prevalent in the field. Vet Microbiol. 2018;219:183-189 pubmed publisher
    The antigenic relationships between the natural reassortment field strains of infectious bursal disease virus (IBDV), and between the field strains and the vaccine strains are poorly understood...
  64. Ouyang W, Qian J, Pan Q, Wang J, Xia X, Wang X, et al. gga-miR-142-5p attenuates IRF7 signaling and promotes replication of IBDV by directly targeting the chMDA5's 3' untranslated region. Vet Microbiol. 2018;221:74-80 pubmed publisher
    ..the regulation of chMDA5 to sense RNA virus infection, but how it exerts antiviral activity against infectious bursal disease virus (IBDV) infection and regulates chMDA5 in chicken cells is unclear...
  65. Mosley Y, Hsieh M, Wu C, Lin T. Eliciting specific humoral immunity from a plasmid DNA encoding infectious bursal disease virus polyprotein gene fused with avian influenza virus hemagglutinin gene. J Virol Methods. 2015;211:36-42 pubmed publisher
    DNA vaccine coding for infectious bursal disease virus (IBDV) polyprotein gene and that for avian influenza virus (AIV) hemagglutinin (HA) gene have been shown to induce immunity and provide protection against the respective disease...
  66. Smith J, Sadeyen J, Butter C, Kaiser P, Burt D. Analysis of the early immune response to infection by infectious bursal disease virus in chickens differing in their resistance to the disease. J Virol. 2015;89:2469-82 pubmed publisher
    Chicken whole-genome gene expression arrays were used to analyze the host response to infection by infectious bursal disease virus (IBDV)...
  67. Liang J, Yin Y, Qin T, Yang Q. Chicken bone marrow-derived dendritic cells maturation in response to infectious bursal disease virus. Vet Immunol Immunopathol. 2015;164:51-5 pubmed publisher
    b>Infectious bursal disease virus (IBDV) is highly contagious disease which easily lead to immunosuppression and a decreased response to vaccinations in young chicken...
  68. Méndez F, de Garay T, Rodríguez D, Rodríguez J. Infectious bursal disease virus VP5 polypeptide: a phosphoinositide-binding protein required for efficient cell-to-cell virus dissemination. PLoS ONE. 2015;10:e0123470 pubmed publisher
    b>Infectious bursal disease virus (IBDV), a member of the Birnaviridae family, is a major avian pathogen responsible for an immunosuppressive disease affecting juvenile chickens. The IBDV genome is formed by two dsRNA segments...
  69. Abed M, Soubies S, Courtillon C, Briand F, Allée C, Amelot M, et al. Infectious bursal disease virus in Algeria: Detection of highly pathogenic reassortant viruses. Infect Genet Evol. 2018;60:48-57 pubmed publisher
    ..The causative agent, the Avibirnavirus IBDV, is a non-enveloped virus whose genome consists of two segments (A and B) of double-stranded RNA...
  70. Ganguly B, Rastogi S. Structural and functional modeling of viral protein 5 of Infectious Bursal Disease Virus. Virus Res. 2018;247:55-60 pubmed publisher
    ..The causative virus (IBDV) is a bi-segmented, double-stranded RNA virus. The virus encodes five major proteins, viral protein (VP) 1-5...
  71. Li Y, He L, Cheng X, Li J, Jia Y, Yang D. Histamine levels in embryonic chicken livers infected with very virulent infectious bursal disease virus. Vet Immunol Immunopathol. 2015;168:91-6 pubmed publisher
    ..histamine levels in embryonic liver and its association with the pathogenicity of a very virulent infectious bursal disease virus (vvIBDV) isolate serially passaged in chicken embryos...
  72. Lee H, Kim J, Kye S, Seul H, Jung S, Choi K. Efficient self-assembly and protective efficacy of infectious bursal disease virus-like particles by a recombinant baculovirus co-expressing precursor polyprotein and VP4. Virol J. 2015;12:177 pubmed publisher
    ..In this study, we developed a VLP vaccine against infectious bursal disease virus (IBDV), which causes morbidity and mortality in chickens, by expressing a baculovirus in insect cells...
  73. Qin L, Qi X, Gao H, Gao Y, Bu Z, Wang X. Exchange of the VP5 of infectious bursal disease virus in a serotype I strain with that of a serotype II strain reduced the viral replication and cytotoxicity. J Microbiol. 2009;47:344-50 pubmed publisher
    b>Infectious bursal disease virus (IBDV), belonging to Avibirnavirus genus in the Birnaviridae family, consists of two segments of double-strand RNA...
  74. Zheng X, Jia L, Hu B, Sun Y, Zhang Y, Gao X, et al. The C-terminal amyloidogenic peptide contributes to self-assembly of Avibirnavirus viral protease. Sci Rep. 2015;5:14794 pubmed publisher
    Unlike other viral protease, Avibirnavirus infectious bursal disease virus (IBDV)-encoded viral protease VP4 forms unusual intracellular tubule-like structures during viral infection...
  75. Lu Z, Zhang L, Wang N, Chen Y, Gao L, Wang Y, et al. Naturally occurring reassortant infectious bursal disease virus in northern China. Virus Res. 2015;203:92-5 pubmed publisher
    b>Infectious bursal disease virus (IBDV) is a bi-segmented, double-stranded RNA virus that belongs to the genus Avibirnavirus of the family of Birnavirideae. The co-evolution of genome segments is a major evolutionary feature for IBDV...
  76. Raja P, Senthilkumar T, Parthiban M, Thangavelu A, Gowri A, Palanisammi A, et al. Complete Genome Sequence Analysis of a Naturally Reassorted Infectious Bursal Disease Virus from India. Genome Announc. 2016;4: pubmed publisher
    The novel infectious bursal disease virus (IBDV) isolate BGE14/ABT1/MVC/India is a very virulent IBDV that was isolated from broiler flocks in southern parts of India during 2014...
  77. Mosley Y, Wu C, Lin T. A free VP3 C-terminus is essential for the replication of infectious bursal disease virus. Virus Res. 2017;232:77-79 pubmed publisher
    Green fluorescent protein (GFP) has been successfully incorporated into the viral-like particles of infectious bursal disease virus (IBDV) with a linker at the C-terminus of VP3 in a baculovirus system...
  78. Mardassi H, Khabouchi N, Ghram A, Namouchi A, Karboul A. A very virulent genotype of infectious bursal disease virus predominantly associated with recurrent infectious bursal disease outbreaks in Tunisian vaccinated flocks. Avian Dis. 2004;48:829-40 pubmed
    ..To characterize the viruses that circumvent protection provided by vaccination, field isolates of infectious bursal disease virus (IBDV) obtained from vaccinated flocks that have repeatedly experienced IBDV outbreak episodes were ..
  79. Chimeno Zoth S, Carballeda J, Gravisaco M, Lucero M, Richetta M, Gómez E, et al. Immunomodulatory effect of baculovirus in chickens: How it modifies the immune response against infectious bursal disease virus. Antiviral Res. 2016;131:35-9 pubmed publisher
    ..investigation, we aimed to assess the potential antiviral effect of BV given both, before and after infectious bursal disease virus (IBDV)...
  80. Gimenez M, Zanetti F, Terebiznik M, Colombo M, Delgui L. Infectious Bursal Disease Virus hijacks endosomal membranes as the scaffolding structure for viral replication. J Virol. 2018;: pubmed publisher
    ..Here, we demonstrated that the Infectious Bursal Disease Virus (IBDV), a prototypical member of the Birnaviridae family, hijacks endosomal membranes of ..
  81. Andoh K, Yamazaki K, Honda Y, Honda T. Turkey herpesvirus with an insertion in the UL3-4 region displays an appropriate balance between growth activity and antibody-eliciting capacity and is suitable for the establishment of a recombinant vaccine. Arch Virol. 2017;162:931-941 pubmed publisher
    We constructed turkey herpesvirus (HVT) vector vaccines in which the VP2 gene of infectious bursal disease virus (IBDV) was inserted into the HVT genome in the following regions: UL3-4, UL22-23, UL45-46, and US10-SORF3...
  82. Li K, Liu Y, Zhang Y, Gao L, Liu C, Cui H, et al. Protective efficacy of a novel recombinant Marek's disease virus vector vaccine against infectious bursal disease in chickens with or without maternal antibodies. Vet Immunol Immunopathol. 2017;186:55-59 pubmed publisher
    ..to control IBD, a Marek's disease virus (MDV) vector vaccine (rMDV-VP2) expressing the VP2 gene of infectious bursal disease virus (IBDV) has been developed...
  83. Han C, Zeng X, Yao S, Gao L, Zhang L, Qi X, et al. Voltage-Dependent Anion Channel 1 Interacts with Ribonucleoprotein Complexes To Enhance Infectious Bursal Disease Virus Polymerase Activity. J Virol. 2017;91: pubmed publisher
    b>Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus. Segment A contains two overlapping open reading frames (ORFs), which encode viral proteins VP2, VP3, VP4, and VP5...
  84. Chi J, You L, Li P, Teng M, Zhang G, Luo J, et al. Surface IgM λ light chain is involved in the binding and infection of infectious bursal disease virus (IBDV) to DT40 cells. Virus Genes. 2018;54:236-245 pubmed publisher
    b>Infectious bursal disease virus (IBDV) is an important immunosuppressive virus in chickens...
  85. Ye C, Jia L, Sun Y, Hu B, Wang L, Lu X, et al. Inhibition of antiviral innate immunity by birnavirus VP3 protein via blockage of viral double-stranded RNA binding to the host cytoplasmic RNA detector MDA5. J Virol. 2014;88:11154-65 pubmed publisher
    ..b>Infectious bursal disease virus (IBDV) evades host innate immunity, but the mechanism is unclear...
  86. Zhang L, Ren X, Chen Y, Gao Y, Wang N, Lu Z, et al. Chondroitin sulfate N-acetylgalactosaminyltransferase-2 contributes to the replication of infectious bursal disease virus via interaction with the capsid protein VP2. Viruses. 2015;7:1474-91 pubmed publisher
    b>Infectious bursal disease virus (IBDV) is a birnavirus that causes a highly contagious immunosuppressive disease in young chickens. The capsid protein VP2 of IBDV plays multiple roles in its life cycle...
  87. Lin J, Xia J, Zhang K, Yang Q. Genome-wide profiling of chicken dendritic cell response to infectious bursal disease. BMC Genomics. 2016;17:878 pubmed
    b>Avian infectious bursal disease virus (IBDV) is a highly contagious, immunosuppressive disease of young chickens, which causes high mortality rates and large economic losses in the poultry industry...
  88. Hornyák Ã, Lipinski K, Bakonyi T, Forgách P, Horváth E, Farsang A, et al. Effective multiple oral administration of reverse genetics engineered infectious bursal disease virus in mice in the presence of neutralizing antibodies. J Gene Med. 2015;17:116-31 pubmed publisher
    ..The clinically tested infectious bursal disease virus (IBDV) superinfection therapy promises an innovative, interferon-free solution to this great unmet ..
  89. Li Z, Qi X, Ren X, Cui L, Wang X, Zhu P. Molecular characteristics and evolutionary analysis of a very virulent infectious bursal disease virus. Sci China Life Sci. 2015;58:731-8 pubmed publisher
    b>Infectious bursal disease virus (IBDV) poses a significant threat to the poultry industry...
  90. Senthilkumar T, Priyadharsini C, Raja P, Kumanan K. Complete Genome Sequence of a Chicken Embryo Fibroblast-Adapted Attenuated Infectious Bursal Disease Virus Isolate from India. Genome Announc. 2016;4: pubmed publisher
    b>Infectious bursal disease virus is an avian pathogen that causes huge morbidity and mortality in the poultry sector all over the world...
  91. Kurukulsuriya S, Ahmed K, Ojkic D, Gunawardana T, Gupta A, Goonewardene K, et al. Circulating strains of variant infectious bursal disease virus may pose a challenge for antibiotic-free chicken farming in Canada. Res Vet Sci. 2016;108:54-9 pubmed publisher
    ..b>Infectious bursal disease virus (IBDV) causes immunosuppression and predisposes chickens to secondary infections...
  92. Marugán Hernández V, Cockle C, Macdonald S, Pegg E, Crouch C, Blake D, et al. Viral proteins expressed in the protozoan parasite Eimeria tenella are detected by the chicken immune system. Parasit Vectors. 2016;9:463 pubmed publisher
    ..b>Infectious bursal disease virus (IBDV) causes Gumboro, an immunosuppressive disease that affects productivity and can interfere with ..