Alphapapillomavirus 7


Alias: Human papillomavirus - 18, Human papillomavirus 18

Top Publications

  1. Kelley M, Keiger K, Lee C, Huibregtse J. The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase. J Virol. 2005;79:3737-47 pubmed publisher
    ..Together, these results suggest that E6AP mediates a broad spectrum of E6 functions, including virtually all functions that impact on the transcriptional program of HPV-positive cell lines...
  2. Zhang Y, Dasgupta J, Ma R, Banks L, Thomas M, Chen X. Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein. J Virol. 2007;81:3618-26 pubmed publisher
    ..In addition to its novel insights into the biochemistry of PDZ interactions, this study is important for understanding HPV-induced oncogenesis; this could provide a basis for developing antiviral and anticancer compounds...
  3. Kim M, Kim Y, Kim H, Kang M, Park J, Lee D, et al. O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes. Oncotarget. 2016;7:44596-44607 pubmed publisher
    ..These findings identify OGT as a novel cellular factor involved in E6 and E7 expressions and cervical cancer tumorigenesis, suggesting that targeting OGT in cervical cancer may have potential therapeutic benefit. ..
  4. Zhou Z, Zhao C, Li Q, Zeng Y. A novel mutant of human papillomavirus type 18 E6E7 fusion gene and its transforming activity. Asian Pac J Cancer Prev. 2014;15:7395-9 pubmed
    ..These results suggest that the mutant should undergo further study for application as a safe antigen- specific therapeutic vaccine for HPV18-associated tumors. ..
  5. Wiwanitkit V. Interaction between interferon regulatory factor-1 and human papillomavirus E7 oncogene in cervical cancer: an ontology study. Taiwan J Obstet Gynecol. 2009;48:138-41 pubmed publisher
    ..IRF-1-E7 was shown to be responsible for the positive regulation of many interleukins and to be involved in the differentiation of T-helper cells. ..
  6. Chen S, Hsu N, Wu J, Chen C, Chou M, Lee H, et al. Association of p53 codon 72 genotypes and clinical outcome in human papillomavirus-infected lung cancer patients. Ann Thorac Surg. 2013;95:1196-203 pubmed publisher
    ..The combination of HPV 16/18 E6 status and p53 codon72 polymorphism in lung tumors is an important biologic and prognostic parameter. ..
  7. Ganti K, Massimi P, Manzo Merino J, Tomaic V, Pim D, Playford M, et al. Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways. PLoS Pathog. 2016;12:e1005854 pubmed publisher
    ..These results demonstrate that E6 interaction with SNX27 can alter the recycling of cargo molecules, one consequence of which is modulation of nutrient availability in HPV transformed tumour cells. ..
  8. Evans M, Peng Z, Clark K, Adamson C, Ma X, Wu X, et al. HPV E6/E7 RNA in situ hybridization signal patterns as biomarkers of three-tier cervical intraepithelial neoplasia grade. PLoS ONE. 2014;9:e91142 pubmed publisher
    ..g. among young women) or when 'LSIL vs. HSIL' assignment is equivocal. ..
  9. Richards K, Doble R, Wasson C, Haider M, Blair G, Wittmann M, et al. Human papillomavirus E7 oncoprotein increases production of the anti-inflammatory interleukin-18 binding protein in keratinocytes. J Virol. 2014;88:4173-9 pubmed publisher
    ..A consequence of increased IL-18BP production is a reduction in CD4-positive lymphocyte activation in response to IL-18 costimulation. These findings may shed light on the immune evasion abilities of HPV. ..

More Information


  1. Zhang K, Lu Q, Niu X, Zhang P, Zhao J, Wang Z, et al. Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression. Acta Pharmacol Sin. 2009;30:153-8 pubmed publisher
    ..Repression of HPV18 E6/E7 expression by Notch1 signaling results in the activation of p53-mediated pathways with concomitant growth suppression of HPV18-positive EC109 cells. ..
  2. Ainsworth J, Thomas M, Banks L, Coutlee F, Matlashewski G. Comparison of p53 and the PDZ domain containing protein MAGI-3 regulation by the E6 protein from high-risk human papillomaviruses. Virol J. 2008;5:67 pubmed publisher
  3. Lee K, Lee A, Kwon Y, Kwon H. Suppression of HPV E6 and E7 expression by BAF53 depletion in cervical cancer cells. Biochem Biophys Res Commun. 2011;412:328-33 pubmed publisher
    ..These results suggest that activated expression of the E6 and E7 genes of integrated HPV is dependent on BAF53-dependent higher-order chromatin structure or nuclear motor activity. ..
  4. Tan C, Gunaratne J, Lai D, Carthagena L, Wang Q, Xue Y, et al. HPV-18 E2^E4 chimera: 2 new spliced transcripts and proteins induced by keratinocyte differentiation. Virology. 2012;429:47-56 pubmed publisher
  5. Wang Y, Chang H, Lin C, Yu W. HPV-18 E7 conjugates to c-Myc and mediates its transcriptional activity. Int J Biochem Cell Biol. 2007;39:402-12 pubmed
    ..Taken together, these results provide significant new insights into the association of c-Myc with E7 and the possible involvement of high-risk E7 in oncogenesis. ..
  6. Jeon J, Cho S, Kim C, Shin D, Jang G, Lee H, et al. Alteration of Rb binding to HPV 18 E7 modified by transglutaminase 2 with different type of polyamines. Front Biosci. 2006;11:1540-8 pubmed
    ..Spermine was more effective in inhibiting E7 activity than spermidine. These results may provide the basis for future investigation aiming at delineating the significance of polyamine metabolism on HPV E7 functions. ..
  7. Kieback E, Muller M. Factors influencing subcellular localization of the human papillomavirus L2 minor structural protein. Virology. 2006;345:199-208 pubmed
    ..In contrast to HPV 11 and 16 L2, the HPV 18 L2 protein seems to require L1 for efficient nuclear accumulation. ..
  8. Kim Y, Chaturvedi P, Chun S, Lee Y, Ahn W. Honeybee venom possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer cell line. Oncol Rep. 2015;33:1675-82 pubmed publisher
    ..Collectively, BV plays a differential role in suppressing HPV16-infected cells (CaSki cells) and HPV18-infected cells (HeLa cells) by the downregulation of E6/E7 protein of HPV16/18. ..
  9. Chakraborty S, Das K, Saha S, Mazumdar M, Manna A, Chakraborty S, et al. Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone deacetylation. J Biol Chem. 2014;289:29074-85 pubmed publisher
    ..These results also justify the candidature of curcumin for the treatment of HPV18-infected cervical carcinoma. ..
  10. Vázquez Vega S, Sánchez Suárez L, Andrade Cruz R, Castellanos Juárez E, Contreras Paredes A, Lizano Soberón M, et al. Regulation of p14ARF expression by HPV-18 E6 variants. J Med Virol. 2013;85:1215-21 pubmed publisher
    ..In conclusion, each E6 variant distinctively affects p53 levels and consequently p14(ARF) expression, finding that could be related with the differences in oncogenic effect of infection with the diverse high-risk HPV variants. ..
  11. Darnell G, Antalis T, Rose B, Suhrbier A. Silencing of integrated human papillomavirus type 18 oncogene transcription in cells expressing SerpinB2. J Virol. 2005;79:4246-56 pubmed
    ..PAI-2 expression thus has a potent suppressive effect on HPV-18 oncogene transcription mediated by Rb and LIP, a finding with potential implications for prognosis and treatment of HPV-transformed lesions. ..
  12. Yaginuma Y, Yoshimoto M, Eguchi A, Tokuda A, Takahashi S. The human papillomavirus18 E7 protein inhibits CENP-C binding to α-satellite DNA. Virus Res. 2015;205:27-32 pubmed publisher
    ..We therefore speculate that altered function of kinetochores as a result of inhibition of CENP-C and α-satellite DNAs binding may be associated with the chromosomal abnormalities observed in HPV18-positive cancers. ..
  13. Genovese N, Banerjee N, Broker T, Chow L. Casein kinase II motif-dependent phosphorylation of human papillomavirus E7 protein promotes p130 degradation and S-phase induction in differentiated human keratinocytes. J Virol. 2008;82:4862-73 pubmed publisher
    ..Collectively, these data support the notion that p130 controls the homeostasis of the differentiated keratinocytes and is therefore targeted by E7 for degradation to establish conditions permissive for viral DNA amplification. ..
  14. Wu L, Yang W, Chen L, Chen S, Zhang J. In vitro antigen-specific cytotoxic T cell response against esophageal carcinoma cells induced by HPV18E7-transfected dendritic cells. Histol Histopathol. 2010;25:197-203 pubmed publisher
    ..5%, and 4) the specific cytotoxicity against EC cells was significantly higher than that in controls (p<0.01). This study indicates the possibility of a DC-based immunotherapy in HPV-associated EC. ..
  15. Ryzhakova O, Solov eva N. [Matrix metalloproteinases (MMP)--MMP-1,-2,-9 and its endogenous activity regulators in transformed by E7 oncogene HPV16 and HPV18 cervical carcinoma cell lines]. Biomed Khim. 2013;59:530-40 pubmed
  16. Gupta G, Glueck R, Rishi N. Physicochemical characterization and immunological properties of Pichia pastoris based HPV16L1 and 18L1 virus like particles. Biologicals. 2017;46:11-22 pubmed publisher
    ..These data establish a blueprint of HPV recombinant protein antigens for standardizing & developing an alternative high-quality, cost-effective vaccine for HPV as well as similar recombinant protein-based vaccines. ..
  17. Singh N, Senapati S, Bose K. Insights into the mechanism of human papillomavirus E2-induced procaspase-8 activation and cell death. Sci Rep. 2016;6:21408 pubmed publisher
    ..Furthermore, our data establish a model for E2-induced apoptosis in HR-HPV types and provide important clues for designing E2 analogs that might modulate procaspase-8 activation and hence apoptosis. ..
  18. Chen L, Wu Y, Liu P, Wang J, Wang G, Qin J, et al. Down-regulation of HPV18 E6, E7, or VEGF expression attenuates malignant biological behavior of human cervical cancer cells. Med Oncol. 2011;28 Suppl 1:S528-39 pubmed publisher
    ..This suppression attenuates malignant biological behavior of human cervical cancer cells. RNA interference of HPV E6/E7 or VEGF expression implies an effective anti-cervical cancer strategy. ..
  19. Tan C, Teissier S, Gunaratne J, Quek L, Bellanger S. Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy. Cell Cycle. 2015;14:1459-70 pubmed publisher
    ..Moreover, our results suggest a role of p53 in regulating the mitotic process itself and highlight SAC over-activation in a p53-negative context as a highly pathogenic event. ..
  20. Teissier S, Pang C, Thierry F. The E2F5 repressor is an activator of E6/E7 transcription and of the S-phase entry in HPV18-associated cells. Oncogene. 2010;29:5061-70 pubmed publisher
    ..Diverting the function of E2F5 from a cell-cycle repressor into an activator might contribute to the higher oncogenic potential of HPV18 when compared with other high-risk HPV types...
  21. Tomaic V, Pim D, Thomas M, Massimi P, Myers M, Banks L. Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD. J Virol. 2011;85:3120-7 pubmed publisher
  22. Cole S, Danos O. Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products. J Mol Biol. 1987;193:599-608 pubmed
    ..Both gene products bear a striking resemblance to the transcriptional factor IIIA of Xenopus laevis, the prototype of a new class of nucleic acid binding proteins...
  23. Amador Molina A, Gonz lez Montoya J, Garc a Carranc A, Mohar A, Lizano M. Intratypic changes of the E1 gene and the long control region affect ori function of human papillomavirus type 18 variants. J Gen Virol. 2013;94:393-402 pubmed publisher
    ..Site-directed mutagenesis revealed that at least two positions in the N-terminal domain of E1 could impact its nuclear accumulation...
  24. Wang X, Wang H, McCoy J, Banerjee N, Rader J, Broker T, et al. Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6. RNA. 2009;15:637-47 pubmed publisher
    ..Together, this is the first time a viral oncoprotein has been shown to regulate cellular miRNA expression. Our data have provided new insights into mechanisms by which high-risk HPVs contribute to the development of cervical cancer...
  25. Pim D, Tomaic V, Banks L. The human papillomavirus (HPV) E6* proteins from high-risk, mucosal HPVs can direct degradation of cellular proteins in the absence of full-length E6 protein. J Virol. 2009;83:9863-74 pubmed publisher
  26. Terenzi F, Saikia P, Sen G. Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. EMBO J. 2008;27:3311-21 pubmed publisher
    ..In vitro, recombinant P56, or a small fragment derived from it, inhibited the DNA helicase activity of E1 and E1-mediated HPV DNA replication. These observations delineate the molecular mechanism of IFN's antiviral action against HPV...
  27. Sun L, Zhang G, Li Z, Song T, Huang C, Si L. In GFP with high risk HPV-18E6 fusion protein expressed 293T and MCF-7 cells, the endogenous wild-type p53 could be transiently phosphorylated at multiple sites. J Exp Clin Cancer Res. 2008;27:35 pubmed publisher
    ..In GFP with high risk HPV-18E6 fusion protein expressed 293T and MCF-7 cells, the endogenous wt p53 could be transiently phosphorylated at multiple sites...
  28. Darnell G, Schroder W, Antalis T, Lambley E, Major L, Gardner J, et al. Human papillomavirus E7 requires the protease calpain to degrade the retinoblastoma protein. J Biol Chem. 2007;282:37492-500 pubmed publisher
    ..Calpain, thus, emerges as a central player in E7-mediated degradation of Rb and represents a potential new drug target for the treatment of HPV-associated lesions...
  29. Wilson R, Ryan G, Knight G, Laimins L, Roberts S. The full-length E1E4 protein of human papillomavirus type 18 modulates differentiation-dependent viral DNA amplification and late gene expression. Virology. 2007;362:453-60 pubmed publisher
    ..This suggests that type-specific differences exist between various E1E4 proteins...
  30. Kuner R, Vogt M, Sultmann H, Buness A, Dymalla S, Bulkescher J, et al. Identification of cellular targets for the human papillomavirus E6 and E7 oncogenes by RNA interference and transcriptome analyses. J Mol Med (Berl). 2007;85:1253-62 pubmed publisher
    ..Comparison with published microarray data revealed a substantial concordance between the genes repressed by RNAi-mediated E6/E7 silencing in HeLa cells and genes reported to be upregulated in HPV-positive cervical cancer biopsies...
  31. Zhou Y, Wei Y, Zhu J, Wang Q, Bao L, Ma Y, et al. GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers. PLoS ONE. 2011;6:e22065 pubmed publisher
    ..Tumor xenograft studies also revealed the suppression of p53 degradation in presence of GRIM-19. These data suggest that GRIM-19 can block E6/E6AP complex; and synergistically suppress cervical tumor growth with p53...
  32. De la Cruz Hern ndez E, Garc a Carranc A, Mohar Betancourt A, Due as Gonz lez A, Contreras Paredes A, P rez Cardenas E, et al. Differential splicing of E6 within human papillomavirus type 18 variants and functional consequences. J Gen Virol. 2005;86:2459-68 pubmed publisher
    ..These results suggest that different splicing patterns of E6 within HPV type 18 variants may possibly have biological implications in viral tumorigenesis...
  33. Wei Q. Pitx2a binds to human papillomavirus type 18 E6 protein and inhibits E6-mediated P53 degradation in HeLa cells. J Biol Chem. 2005;280:37790-7 pubmed publisher
    ..Taken together, these findings suggest that, by binding to E6, Pitx2a interferes with E6/E6AP-mediated p53 degradation, leading to the accumulation of functional p53 protein in HeLa cells...
  34. Bellanger S, Blachon S, Mechali F, Bonne Andrea C, Thierry F. High-risk but not low-risk HPV E2 proteins bind to the APC activators Cdh1 and Cdc20 and cause genomic instability. Cell Cycle. 2005;4:1608-15 pubmed publisher
    ..The finding that high-risk, but not low-risk HPV E2 proteins, induce genomic instability, raises the intriguing possibility that E2 proteins play a role in the oncogenic potential of high-risk papillomaviruses...
  35. Turan T, Kalantari M, Calleja Macias I, Cubie H, Cuschieri K, Villa L, et al. Methylation of the human papillomavirus-18 L1 gene: a biomarker of neoplastic progression?. Virology. 2006;349:175-83 pubmed publisher
  36. Ren C, Cheng X, Lu B, Yang G. Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironme. Eur J Cancer. 2013;49:3889-99 pubmed publisher
    ..Thus, we have uncovered a mechanism that fibroblast senescence promotes cervical cancer development through high-risk HPV E6-activated IL-6/STAT3 signalling in tumour microenvironment...
  37. Kho E, Wang H, Banerjee N, Broker T, Chow L. HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures. Proc Natl Acad Sci U S A. 2013;110:7542-9 pubmed publisher
  38. Storrs C, Silverstein S. PATJ, a tight junction-associated PDZ protein, is a novel degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6. J Virol. 2007;81:4080-90 pubmed publisher
    ..We also demonstrate that 18 E6-mediated degradation of PATJ is not inhibited in cells where E6AP is silenced by shRNA. This suggests that the E6-E6AP complex is not required for the degradation of this protein target...
  39. Teissier S, Ben Khalifa Y, Mori M, Pautier P, Desaintes C, Thierry F. A new E6/P63 pathway, together with a strong E7/E2F mitotic pathway, modulates the transcriptome in cervical cancer cells. J Virol. 2007;81:9368-76 pubmed publisher
    ..Importantly, a subset of the mitotic genes was shown to be significantly induced in biopsies of stage IV cervical cancers, which points to a prominent E7 pathway in cervical carcinoma...
  40. Banerjee N, Wang H, Broker T, Chow L. Human papillomavirus (HPV) E7 induces prolonged G2 following S phase reentry in differentiated human keratinocytes. J Biol Chem. 2011;286:15473-82 pubmed publisher
    ..Collectively, this study has revealed the mechanisms by which E7 induces prolonged G(2) phase in the differentiated cells following S phase induction...
  41. Knight G, Pugh A, Yates E, Bell I, Wilson R, Moody C, et al. A cyclin-binding motif in human papillomavirus type 18 (HPV18) E1^E4 is necessary for association with CDK-cyclin complexes and G2/M cell cycle arrest of keratinocytes, but is not required for differentiation-dependent viral genome amplification or L. Virology. 2011;412:196-210 pubmed publisher
    ..We conclude that the HPV18 E4 G2/M arrest function does not play a role in early vegetative events...
  42. Bellanger S, Tan C, Nei W, He P, Thierry F. The human papillomavirus type 18 E2 protein is a cell cycle-dependent target of the SCFSkp2 ubiquitin ligase. J Virol. 2010;84:437-44 pubmed publisher
  43. Contreras Paredes A, De la Cruz Hern ndez E, Mart nez Ram rez I, Due as Gonz lez A, Lizano M. E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway. Virology. 2009;383:78-85 pubmed publisher
    ..Results suggest that HPV18 intra-type variations may derive in differential abilities to activate cell-signaling pathways such as Akt/PKB and MAPKs, directly involved in cell survival and proliferation...
  44. Liu S, Tian Y, Greenaway F, Sun M. A C-terminal hydrophobic, solvent-protected core and a flexible N-terminus are potentially required for human papillomavirus 18 E7 protein functionality. Biochimie. 2010;92:901-8 pubmed publisher
    ..Both factors, the relative flexibility of the pRb binding motif at the N-terminus and the C-terminal metal-binding hydrophobic solvent-protected core, combine together and facilitate the biological functions of HPV-18 E7...
  45. Thierry F, Demeret C. Direct activation of caspase 8 by the proapoptotic E2 protein of HPV18 independent of adaptor proteins. Cell Death Differ. 2008;15:1356-63 pubmed publisher
    ..Our results provide evidence for adaptor-independent oligomerization of caspase 8, mediated by non-DFD direct interactions with the HPV18 E2 protein, thus deciphering a new pathway for caspase 8 activation...
  46. Qi Z, Xu X, Zhang B, Li Y, Liu J, Chen S, et al. Effect of simultaneous silencing of HPV-18 E6 and E7 on inducing apoptosis in HeLa cells. Biochem Cell Biol. 2010;88:697-704 pubmed publisher
    ..These data suggest that gene therapy may be a possible therapeutic approach for HPV-positive cervical cancers...
  47. Cha S, Seo T. hSNF5 is required for human papillomavirus E2-driven transcriptional activation and DNA replication. Intervirology. 2011;54:66-77 pubmed publisher
    ..These results suggest that the SWI/SNF complex is involved in HPV E2-driven transcription and DNA replication via interaction with E2...
  48. Magaldi T, Almstead L, Bellone S, Prevatt E, Santin A, DiMaio D. Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation. Virology. 2012;422:114-24 pubmed publisher
    ..These data suggest that E6 and E7 dependence is an inherent property of human cervical cancer cells...
  49. Fiedler M, Ressler S, Campo Fern ndez B, Laich A, Jansen L, Widschwendter A, et al. Expression of the high-risk human papillomavirus type 18 and 45 E7 oncoproteins in cervical carcinoma biopsies. J Gen Virol. 2005;86:3235-41 pubmed publisher
    ..Together with anti-HPV-16 E7 antibodies, this could create the possibility of detecting E7 oncoproteins in approximately 80 % of all cervical cancers...
  50. Ueno T, Sasaki K, Yoshida S, Kajitani N, Satsuka A, Nakamura H, et al. Molecular mechanisms of hyperplasia induction by human papillomavirus E7. Oncogene. 2006;25:4155-64 pubmed publisher
    ..However, analysis with the E7 variants indicated that other pocket proteins are also involved in the activity...
  51. Johung K, Goodwin E, DiMaio D. Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J Virol. 2007;81:2102-16 pubmed publisher
  52. Leiprecht N, Munoz C, Alesutan I, Siraskar G, Sopjani M, F ller M, et al. Regulation of Na(+)-coupled glucose carrier SGLT1 by human papillomavirus 18 E6 protein. Biochem Biophys Res Commun. 2011;404:695-700 pubmed publisher
    ..This study explored the possibility that the human papillomavirus 18 E6 protein HPV18 E6 (E6) participates in the stimulation of SGLT1 activity...
  53. Collins S, Constandinou Williams C, Wen K, Young L, Roberts S, Murray P, et al. Disruption of the E2 gene is a common and early event in the natural history of cervical human papillomavirus infection: a longitudinal cohort study. Cancer Res. 2009;69:3828-32 pubmed publisher
  54. Favre Bonvin A, Reynaud C, Kretz Remy C, Jalinot P. Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome. J Virol. 2005;79:4229-37 pubmed publisher
    ..These results support the notion that HPV-18 E6 renders cells less sensitive to the cytostatic effect of TGF-beta by lowering the intracellular amount of TIP-2/GIPC...
  55. Clere N, Bermont L, Fauconnet S, Lascombe I, Saunier M, Vettoretti L, et al. The human papillomavirus type 18 E6 oncoprotein induces Vascular Endothelial Growth Factor 121 (VEGF121) transcription from the promoter through a p53-independent mechanism. Exp Cell Res. 2007;313:3239-50 pubmed publisher
    ..Collectively, these results suggest that HPV18 E6 oncoprotein contributes to tumor angiogenesis by inducing VEGF transcription from the promoter in a p53-independent manner...
  56. Thomas M, Chiang C. E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation. Mol Cell. 2005;17:251-64 pubmed publisher
  57. Lee S, Weiss R, Javier R. Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci U S A. 1997;94:6670-5 pubmed
    ..domain-binding motifs at their C termini and, significantly, human T cell leukemia virus type 1 Tax and human papillomavirus 18 E6 proteins bound DLG in vitro...
  58. Garc a Alai M, Dantur K, Smal C, Pietrasanta L, de Prat Gay G. High-risk HPV E6 oncoproteins assemble into large oligomers that allow localization of endogenous species in prototypic HPV-transformed cell lines. Biochemistry. 2007;46:341-9 pubmed publisher
  59. Thomas M, Massimi P, Navarro C, Borg J, Banks L. The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins. Oncogene. 2005;24:6222-30 pubmed publisher
  60. Grm H, Massimi P, Gammoh N, Banks L. Crosstalk between the human papillomavirus E2 transcriptional activator and the E6 oncoprotein. Oncogene. 2005;24:5149-64 pubmed publisher
  61. Tomai V, Pim D, Banks L. The stability of the human papillomavirus E6 oncoprotein is E6AP dependent. Virology. 2009;393:7-10 pubmed publisher
    ..These results demonstrate that the stability of HPV E6 is critically dependent upon the presence of E6AP...
  62. T pffer S, M ller Schiffmann A, Matentzoglu K, Scheffner M, Steger G. Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. J Gen Virol. 2007;88:2956-65 pubmed publisher
    ..Our data suggest that reducing the level of PTPH1 may contribute to the oncogenic activity of high-risk genital E6 proteins...
  63. Yew C, Lee P, Chan W, Lim V, Tay S, Tan T, et al. A novel MLL5 isoform that is essential to activate E6 and E7 transcription in HPV16/18-associated cervical cancers. Cancer Res. 2011;71:6696-707 pubmed publisher
  64. Wu H, Wu J, Cheng Y, Chen C, Lee M, Goan Y, et al. cIAP2 upregulated by E6 oncoprotein via epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway confers resistance to cisplatin in human papillomavirus 16/18-infected lung cancer. Clin Cancer Res. 2010;16:5200-10 pubmed publisher
    ..cIAP2 upregulated by E6 via EGFR/PI3K/AKT cascades may contribute to cisplatin resistance, revealing that the EGFR or PI3K inhibitor combined with cisplatin may improve the chemotherapeutic efficacy in HPV-infected lung cancer...
  65. Hsu N, Cheng Y, Chan I, Ho H, Chen C, Hsu C, et al. Association between expression of human papillomavirus 16/18 E6 oncoprotein and survival in patients with stage I non-small cell lung cancer. Oncol Rep. 2009;21:81-7 pubmed
    ..055). Expression of HPV-16/18 E6 oncoprotein in stage I NSCLC may play an important role in female adenocarcinoma patients and survival benefits in patients who expressed HPV-16 and HPV-18 E6 oncoprotein...
  66. Chi C, Bach A, Engstr m k, Str mgaard K, Lundstr m P, Ferguson N, et al. Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97. J Biol Chem. 2011;286:3597-606 pubmed publisher
    ..This is consistent with a larger proportion of the protein surface defining binding specificity, as compared with that reported previously...
  67. Kranjec C, Banks L. A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose loss accompanies disruption of tight junctions. J Virol. 2011;85:1757-64 pubmed publisher
  68. Liu Y, Henry G, Hegde R, Baleja J. Solution structure of the hDlg/SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein. Biochemistry. 2007;46:10864-74 pubmed publisher
    ..Comparison of the NMR complex structure to previously determined X-ray structures of PDZ2 by itself and bound to different peptides allows a description of conformational changes required for PDZ2 to bind to HPV-18 E6...
  69. Fertey J, Hurst J, Straub E, Schenker A, Iftner T, Stubenrauch F. Growth inhibition of HeLa cells is a conserved feature of high-risk human papillomavirus E8^E2C proteins and can also be achieved by an artificial repressor protein. J Virol. 2011;85:2918-26 pubmed publisher