Autographa californica nucleopolyhedrovirus

Summary

Alias: Autographa californica multicapsid nuclear polyhedrosis virus, Autographa californica multicapsid nuclear polyhedrosis virus AcMNPV, Autographa californica nuclear polyhedrosis virus, Autographa californica nuclear polyhedrosis virus AcMNPV, Autographa californica nuclear polyhedrosis virus AcNPV, Autographa californica nuclear polyhedrosis virus, AcMNPV, AcMNPV

Top Publications

  1. Kelly B, Chapple S, Allen C, Pritchard C, King L, Possee R. Extended budded virus formation and induction of apoptosis by an AcMNPV FP-25/p35 double mutant in Trichoplusia ni cells. Virus Res. 2008;133:157-66 pubmed publisher
    An Autographa californica nucleopolyhedrovirus (AcMNPV) mutant (AcdefrT) isolated from virus-infected Trichoplusia ni (TN-368) cells produced plasma membrane blebbing and caspase-3-like activity late in infection...
  2. Li G, Wang J, Deng R, Wang X. Characterization of AcMNPV with a deletion of ac68 gene. Virus Genes. 2008;37:119-27 pubmed publisher
    Orf68 (ac68) of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is a highly conserved gene that codes a predicted 192-amino acid protein, but its function remains unknown...
  3. Wu Y, Liu C, Wu C, Wang C, Lee S, Chao Y. Cooperation of ie1 and p35 genes in the activation of baculovirus AcMNPV and HzNV-1 promoters. Virus Res. 2008;135:247-54 pubmed publisher
    ..Here we show that infection of baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) could activate the expression of the hhi1 promoter...
  4. Ribeiro B, Generino A, Acacio C, Kalapothakis E, B o S. Characterization of a new Autographa californica multiple nucleopolyhedrovirus (AcMNPV) polyhedra mutant. Virus Res. 2009;140:1-7 pubmed publisher
    ..During the purification of an AcMNPV recombinant virus, a mutant virus was isolated...
  5. Ardisson Araujo D, da Silva A, Melo F, Dos Santos E, Sosa Gómez D, Ribeiro B. A Novel Betabaculovirus Isolated from the Monocot Pest Mocis latipes (Lepidoptera: Noctuidae) and the Evolution of Multiple-Copy Genes. Viruses. 2018;10: pubmed publisher
    ..We also characterized the granulin gene using a recombinant Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and found that occlusion bodies were produced into the nucleus of infected cells and presented a polyhedral shape ..
  6. Woestmann L, Gibbs M, Hesketh H, Saastamoinen M. Viral exposure effects on life-history, flight-related traits, and wing melanisation in the Glanville fritillary butterfly. J Insect Physiol. 2018;107:136-143 pubmed publisher
    ..We used the Alphabaculovirus type strain Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and demonstrated that positive concentration-dependent baculovirus exposure leads to prolonged developmental time ..
  7. Li M, Zheng G, Su R, Wan F, Li C. A new cell line derived from embryonic tissues of Holotrichia parallela (Coleoptera:Scarabaeidae). In Vitro Cell Dev Biol Anim. 2016;52:683-9 pubmed publisher
    ..7 h. Cell line Hp-E-1 could not be infected by three viruses Autographa californica multiple nucleopolyhedrovirus (AcMNPV), Bombyx mori nucleopolyhedrovirus (BmNPV), and Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV).
  8. Wei W, Wang H, Li X, Fang N, Yang S, Liu H, et al. Cloning and Characterization of Sf9 Cell Lamin and the Lamin Conformational Changes during Autographa californica multiple nucleopolyhedrovirus Infection. Viruses. 2016;8: pubmed publisher
    ..Transmission electron microscopy observations indicated that Autographa californica multiple nucleopolyhedrovirus (AcMNPV) nucleocapsids may pass through the nuclear envelope...
  9. Hakim M, Mandelbaum A, Fass D. Structure of a baculovirus sulfhydryl oxidase, a highly divergent member of the erv flavoenzyme family. J Virol. 2011;85:9406-13 pubmed publisher
    ..but the baculovirus enzyme, the product of the Ac92 gene in Autographa californica multiple nucleopolyhedrovirus (AcMNPV), is highly divergent at the amino acid sequence level...

More Information

Publications181 found, 100 shown here

  1. Chejanovsky N. Using the Baculovirus/Insect Cell System to Study Apoptosis. Methods Mol Biol. 2016;1350:477-89 pubmed publisher
    ..The utilization of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) to identify genes that inhibit the apoptotic process will be described using a transfection-based approach, ..
  2. Abdallah N, El Menofy W, Abdelhadi A. Designing of a Recombinant Agip Bacmid Construct with Infectious Properties Against Black Cutworm Agrotis ipsilon Larvae. Appl Biochem Biotechnol. 2017;183:307-317 pubmed publisher
    ..The amplified gp_119 fragment was cloned into the BAC_Bsu361 plasmid derived from the AcMNPV Bac-to-Bac® system...
  3. Salem T, Zhang F, Sahly N, Thiem S. Effect of Temporal Expression of Integral Membrane Proteins by Baculovirus Expression Vector System. Mol Biotechnol. 2018;60:576-584 pubmed publisher
    ..the expression of eight different IMPs has been compared under vp39 and polh promoters of Autographa californica nucleopolyhedrovirus. Although different IMPs have shown different patterns of expression, the expression driven by ..
  4. Shin H, Franco L, Nair V, Collins A, Shiloh M. A baculovirus-conjugated mimotope vaccine targeting Mycobacterium tuberculosis lipoarabinomannan. PLoS ONE. 2017;12:e0185945 pubmed publisher
    ..keyhole limpet hemocyanin (KLH) or to the baculovirus Autographa californica multicapsid nucleopolyherovirus (AcMNPV) when introduced into mice by injection or via intranasal inoculation, respectively...
  5. Zhou J, Kong L, Fang N, Mao B, Ai H. Synthesis and Functional Characterization of MAF-1A Peptide Derived From the Larvae of Housefly, Musca domestica (Diptera: Muscidae). J Med Entomol. 2016;53:1467-1472 pubmed
    ..infection of influenza virus H1N1, Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV), and Bombyx mori nuclear polyhydrosis virus (BmNPV), which displayed excellent virucidal activities...
  6. de Oliveira V, da Silva Morgado F, Ardisson Araújo D, Resende R, Ribeiro B. The silencing suppressor (NSs) protein of the plant virus Tomato spotted wilt virus enhances heterologous protein expression and baculovirus pathogenicity in cells and lepidopteran insects. Arch Virol. 2015;160:2873-9 pubmed publisher
    ..we showed that cell death induced by a recombinant (vAcNSs) Autographa californica multiple nucleopolyhedrovirus (AcMNPV) expressing the silencing suppressor (NSs) protein of Tomato spotted wilt virus (TSWV) was enhanced on permissive ..
  7. Tang Q, Wu P, Hu Z, Yang Y, Qiu L, Liu H, et al. Evidence for the role of BmNPV Bm65 protein in the repair of ultraviolet-induced DNA damage. J Invertebr Pathol. 2017;149:82-86 pubmed publisher
    ..mori nucleopolyhedrovirus (BmNPV) ORF Bm65, a homolog of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac79, correlated with decreased inactivation of virus by UV irradiation...
  8. Wang H, Xu W, Kong X, Fan Y, Wu X. Bombyx mori nucleopolyhedrovirus protein Bm11 is involved in occlusion body production and occlusion-derived virus embedding. Virology. 2019;527:12-20 pubmed publisher
    ..It is homologous to AcMNPV orf19. In this study, a bm11 knockout virus was constructed and its role was investigated...
  9. George S, Jauhar A, MacKenzie J, Kieβlich S, Aucoin M. Temporal characterization of protein production levels from baculovirus vectors coding for GFP and RFP genes under non-conventional promoter control. Biotechnol Bioeng. 2015;112:1822-31 pubmed publisher
    ..This work demonstrates the use of different Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) promoters to control the timing and expression of two easily traceable fluorescent proteins, the enhanced green ..
  10. Yang M, Huang C, Qian D, Li L. Functional characterization of Autographa californica multiple nucleopolyhedrovirus gp16 (ac130). Virology. 2014;464-465:341-352 pubmed publisher
    To investigate the function of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) gp16, multiple gp16-knockout and repair mutants were constructed and characterized...
  11. Tang Q, Hu Z, Yang Y, Wu H, Qiu L, Chen K, et al. Overexpression of Bm65 correlates with reduced susceptibility to inactivation by UV light. J Invertebr Pathol. 2015;127:87-92 pubmed publisher
    ..In the present study, Bombyx mori nucleopolyhedrovirus (BmNPV) orf 65 (Bm65), the homolog of Autographa californica nucleopolyhedrovirus orf 79 (Ac79), a predicted endonuclease, was analyzed...
  12. Ai H, Wang F, Xia Y, Chen X, Lei C. Antioxidant, antifungal and antiviral activities of chitosan from the larvae of housefly, Musca domestica L. Food Chem. 2012;132:493-8 pubmed publisher
    ..Besides, antiviral results demonstrated that the chitosan could effectively inhibit the infection of AcMNPV and BmNPV...
  13. Yu Q, Xiong Y, Gao H, Liu J, Chen Z, Wang Q, et al. Comparative proteomics analysis of Spodoptera frugiperda cells during Autographa californica multiple nucleopolyhedrovirus infection. Virol J. 2015;12:115 pubmed publisher
    ..study, Spodoptera frugiperda (Sf9) cells were infected with Autographa californica multiple nucleopolyhedrovirus (AcMNPV)...
  14. Chimeno Zoth S, Carballeda J, Gravisaco M, Lucero M, Richetta M, Gómez E, et al. Immunomodulatory effect of baculovirus in chickens: How it modifies the immune response against infectious bursal disease virus. Antiviral Res. 2016;131:35-9 pubmed publisher
    ..pathogen free chickens were intravenously inoculated with 5 × 10(7) pfu of Autographa californica nuclear polyhedrosis virus and 3 h later were orally administered 2...
  15. Alfonso V, Amalfi S, López M, Taboga O. Effects of deletion of the ac109 gene of Autographa californica nucleopolyhedrovirus on interactions with mammalian cells. Arch Virol. 2017;162:835-840 pubmed publisher
    ..Moreover, the amount of free cytoplasmic viral DNA, which was detected by transcription of a reporter gene, was severely diminished. These results suggest Ac109 could be involved in maintaining the integrity of the viral nucleic acid. ..
  16. Jiantao Liu -, Zhu L, Zhang S, Deng Z, Huang Z, Yuan M, et al. The Autographa californica multiple nucleopolyhedrovirus ac110 gene encodes a new per os infectivity factor. Virus Res. 2016;221:30-7 pubmed publisher
    The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac110 gene is especially conserved in lepidopteran-specific baculoviruses and is uncharacterized...
  17. Shi Y, Li K, Tang P, Li Y, Zhou Q, Yang K, et al. Three-dimensional visualization of the Autographa californica multiple nucleopolyhedrovirus occlusion-derived virion envelopment process gives new clues as to its mechanism. Virology. 2015;476:298-303 pubmed publisher
    ..conventional electron microscopy to study the envelopment of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ODV...
  18. Volkman L. Baculoviruses and nucleosome management. Virology. 2015;476:257-263 pubmed publisher
    ..Retrospective analysis of results of AcMNPV time course experiments wherein actin polymerization was blocked by cytochalasin D drug treatment implicate actin-..
  19. Donly B, Kaplanoglu E, Theilmann D, Baldwin D, Sieminska E, Hegedus D, et al. MacoNPV baculovirus midgut-specific gene expression during infection of the bertha armyworm, Mamestra configurata. Virology. 2016;499:1-8 pubmed publisher
    ..digital PCR and RNA sequencing methods showed the profile of transcription to be different from those produced by AcMNPV BV infection of in vitro cell cultures...
  20. Maghodia A, Jarvis D, Geisler C. Complete Genome Sequence of the Autographa californica Multiple Nucleopolyhedrovirus Strain E2. Genome Announc. 2014;2: pubmed publisher
    ..baculovirus/insect cell system (BICS) are derived from the Autographa californica multiple nucleopolyhedrovirus (AcMNPV) strain E2...
  21. Mc Callum G, Arregui M, Smith I, Bracco L, Wolman F, Cascone O, et al. Recombinant protein purification in baculovirus-infected Rachiplusia nu larvae: An approach towards a rational design of downstream processing strategies based on chromatographic behavior of proteins. Protein Expr Purif. 2019;158:44-50 pubmed publisher
    ..of Rachiplusia nu larvae infected with recombinant Autographa californica multiple nucleopolyhedrosis virus (AcMNPV), in order to design rational purification strategies for the expression of heterologous proteins in this very ..
  22. Costa Navarro G, Amalfi S, López M, Llauger G, Arneodo J, Taboga O, et al. The autographa californica multiple nucleopolyhedrovirus Ac12: A non-essential F box-like protein that interacts with cellular SKP1 component of the E3 ubiquitin ligase complex. Virus Res. 2019;260:67-77 pubmed publisher
    The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac12 gene, which is conserved in ten other baculovirus, codes a predicted 217 amino acid protein of unknown function...
  23. Hodgson J, Buchon N, Blissard G. Identification of insect genes involved in baculovirus AcMNPV entry into insect cells. Virology. 2019;527:1-11 pubmed publisher
    The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is a model enveloped DNA virus that infects and replicates in lepidopteran insect cells, and can efficiently enter a wide variety of non-host cells...
  24. Wang X, Shang Y, Chen C, Liu S, Chang M, Zhang N, et al. Baculovirus Per Os Infectivity Factor Complex: Components and Assembly. J Virol. 2019;93: pubmed publisher
    ..each pif gene was knocked out from the Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) genome individually by use of synthetic baculovirus technology, and the impact on PIF complex formation was ..
  25. Yesilyurt A, Muratoglu H, Demirbag Z, Nalcacioglu R. Chilo iridescent virus encodes two functional metalloproteases. Arch Virol. 2019;164:657-665 pubmed publisher
    ..They were cloned into the Autographa californica multiple nucleopolyhedrovirus (AcMNPV) Bac-to-Bac baculovirus expression-vector system, expressed in insect Sf9 cells with an N-terminal His tag, and ..
  26. Hamajima R, Saito A, Makino S, Kobayashi M, Ikeda M. Antiviral immune responses of Bombyx mori cells during abortive infection with Autographa californica multiple nucleopolyhedrovirus. Virus Res. 2018;258:28-38 pubmed publisher
    ..Here, we characterized apoptosis and rRNA degradation in Autographa californica multiple nucleopolyhedrovirus (AcMNPV)-infected Bombyx mori cells, a system resulting in abortive infection, in relation to viral DNA replication and ..
  27. Molinari P, Molina G, Tavarone E, Del Médico Zajac M, Moron G, Taboga O. Baculovirus capsid display in vaccination schemes: effect of a previous immunity against the vector on the cytotoxic response to delivered antigens. Appl Microbiol Biotechnol. 2018;102:10139-10146 pubmed publisher
    The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, although it also has been used as display vector for vaccine development...
  28. Wang Q, Bosch B, Vlak J, van Oers M, Rottier P, van Lent J. Budded baculovirus particle structure revisited. J Invertebr Pathol. 2016;134:15-22 pubmed publisher
    ..morphology of two intensively studied baculoviruses, Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) and Spodoptera exigua MNPV (SeMNPV), as models for BVs carrying GP64 and F as envelope fusion protein on the ..
  29. Moldován N, Tombácz D, Szucs A, Csabai Z, Balázs Z, Kis E, et al. Third-generation Sequencing Reveals Extensive Polycistronism and Transcriptional Overlapping in a Baculovirus. Sci Rep. 2018;8:8604 pubmed publisher
    The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is an insect-pathogen baculovirus...
  30. Li S, Li L, Zhao H, Liu W. Disruption of Autographa Californica Multiple Nucleopolyhedrovirus ac111 Results in Reduced per os Infectivity in a Host-Dependent Manner. Viruses. 2018;10: pubmed publisher
    The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac111 gene is highly conserved in lepidopteran-specific baculoviruses, and its function in the AcMNPV life cycle is still unknown...
  31. Mehrabadi M, Hussain M, Matindoost L, Asgari S. The Baculovirus Antiapoptotic p35 Protein Functions as an Inhibitor of the Host RNA Interference Antiviral Response. J Virol. 2015;89:8182-92 pubmed publisher
    ..response against DNA viruses, in this study, we found that Autographa californica multiple nucleopolyhedrovirus (AcMNPV) infection similarly induces an RNAi response in Spodoptera frugiperda cells by generating a large number of ..
  32. Fu Y, Li X, Du J, Zheng S, Liang A. Regulation analysis of AcMNPV-mediated expression of a Chinese scorpion neurotoxin under the IE1, P10 and PH promoter in vivo and its use as a potential bio-insecticide. Biotechnol Lett. 2015;37:1929-36 pubmed publisher
    To analyze the regulation mechanism of AcMNPV (Autographa californica multicapsid nucleopolyhedrovirus)-mediated expression of BmK IT under IE1, P10 and PH promoters in the larva of Heliothis armigera....
  33. Li S, Wang M, Shen S, Hu Z, Wang H, Deng F. The FP25K Acts as a Negative Factor for the Infectivity of AcMNPV Budded Virus. PLoS ONE. 2015;10:e0128471 pubmed publisher
    ..FP25K acts as a negative factor for the infectivity of BV. ..
  34. Shikano I, Hua K, Cory J. Baculovirus-challenge and poor nutrition inflict within-generation fitness costs without triggering transgenerational immune priming. J Invertebr Pathol. 2016;136:35-42 pubmed publisher
    ..looper, Trichoplusia ni, with a low dose of the baculovirus, Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and altered dietary protein to carbohydrate ratio (p:c ratio) after virus exposure...
  35. Javed M, Biswas S, Willis L, Harris S, Pritchard C, van Oers M, et al. Autographa californica Multiple Nucleopolyhedrovirus AC83 is a Per Os Infectivity Factor (PIF) Protein Required for Occlusion-Derived Virus (ODV) and Budded Virus Nucleocapsid Assembly as well as Assembly of the PIF Complex in ODV Envelopes. J Virol. 2017;91: pubmed publisher
    ..Autographa californica multiple nucleopolyhedrovirus (AcMNPV) encodes seven PIF proteins, of which PIF1 to PIF4 form a core complex in ODV envelopes to which PIF0 and PIF6 ..
  36. Karamipour N, Fathipour Y, Talebi A, Asgari S, Mehrabadi M. Small interfering RNA pathway contributes to antiviral immunity in Spodoptera frugiperda (Sf9) cells following Autographa californica multiple nucleopolyhedrovirus infection. Insect Biochem Mol Biol. 2018;101:24-31 pubmed publisher
    Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is a well-known virus in the Baculoviridae family...
  37. Fu Y, Zhao J, Liang A, Hu F. AcMNPV-mediated expression of BmK IT promotes the apoptosis of Sf9 cells and replication of AcMNPV. Sheng Li Xue Bao. 2015;67:305-11 pubmed
    ..To promote the insecticidal effects of Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV), the gene encoding an excitatory insect toxin, BmK IT, was inserted into the genome of AcMNPV to construct a ..
  38. Guan Z, Zhong L, Li C, Wu W, Yuan M, Yang K. The Autographa californica Multiple Nucleopolyhedrovirus ac54 Gene Is Crucial for Localization of the Major Capsid Protein VP39 at the Site of Nucleocapsid Assembly. J Virol. 2016;90:4115-4126 pubmed publisher
    ..Nucleocapsid assembly ofAutographa californicamultiple nucleopolyhedrovirus (AcMNPV) requires the major capsid protein VP39 and nine minor capsid proteins, including VP1054...
  39. Shang H, Garretson T, Kumar C, Dieter R, Cheng X. Improved pFastBac™ donor plasmid vectors for higher protein production using the Bac-to-Bac® baculovirus expression vector system. J Biotechnol. 2017;255:37-46 pubmed publisher
    The Autographa californica multiple nucleopolyhedrovirus (AcMNPV)-based Bac-to-Bac® expression system consists of a bacmid and five pFastBac™ donor transfer vectors...
  40. Hamajima R, Kobayashi M, Ikeda M. Identification of amino acid residues of AcMNPV P143 protein involved in rRNA degradation and restricted viral replication in BM-N cells from the silkworm Bombyx mori. Virology. 2015;485:244-51 pubmed publisher
    ..demonstrated that rRNA undergoes rapid and extensive degradation in Bombyx mori BM-N cells upon infection with AcMNPV, which is triggered by AcMNPV P143 (Ac-P143) protein...
  41. Mu J, Zhang Y, Hu Y, Hu X, Zhou Y, Chen X, et al. The role of viral protein Ac34 in nuclear relocation of subunits of the actin-related protein 2/3 complex. Virol Sin. 2016;31:480-489 pubmed publisher
    ..Autographa californica multiple nucleopolyhedrovirus (AcMNPV), one of the beststudied alphabaculoviruses, induces Arp2/3 nuclear relocation and mediates nuclear actin ..
  42. Li J, Sun Y, Li Y, Liu X, Yue Q, Li Z. Inhibition of cellular fatty acid synthase impairs replication of budded virions of Autographa californica multiple nucleopolyhedrovirus in Spodoptera frugiperda cells. Virus Res. 2018;252:41-47 pubmed publisher
    ..the roles of cellular fatty acid synthesis pathway in Autographa californica multiple nucleopolyhedrovirus (AcMNPV) infection is not clear...
  43. Shrestha A, Bao K, Chen Y, Chen W, Wang P, Fei Z, et al. Global Analysis of Baculovirus Autographa californica Multiple Nucleopolyhedrovirus Gene Expression in the Midgut of the Lepidopteran Host Trichoplusia ni. J Virol. 2018;92: pubmed publisher
    The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is a large double-stranded DNA (dsDNA) virus that encodes approximately 156 genes and is highly pathogenic to a variety of larval lepidopteran insects in ..
  44. Lyupina Y, Erokhov P, Kravchuk O, Finoshin A, Abaturova S, Orlova O, et al. Essential function of VCP/p97 in infection cycle of the nucleopolyhedrovirus AcMNPV in Spodoptera frugiperda Sf9 cells. Virus Res. 2018;253:68-76 pubmed publisher
    ..frugiperda (Sf9) cells and analyzed the replication of the Autographa californica multiple nucleopolyhedrovirus, AcMNPV, in Sf9 cells in which the VCP/p97 function was inhibited...
  45. Mitchell J, Friesen P. Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication. J Virol. 2012;86:13542-53 pubmed publisher
    The baculovirus Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) initiates apoptosis in diverse insects through events triggered by virus DNA (vDNA) replication...
  46. Huynh H, Tran T, Chan L, Nielsen L, Reid S. Effect of the peak cell density of recombinant AcMNPV-infected Hi5 cells on baculovirus yields. Appl Microbiol Biotechnol. 2015;99:1687-700 pubmed publisher
    ..In addition, low production rates at late infection stages of moderate to high ICDs are a probable cause of the cell density effect. ..
  47. Beperet I, Simón O, Williams T, López Ferber M, Caballero P. The "11K" gene family members sf68, sf95 and sf138 modulate transmissibility and insecticidal properties of Spodoptera frugiperda multiple nucleopolyhedrovirus. J Invertebr Pathol. 2015;127:101-9 pubmed publisher
    ..to their similarity with the ac145 or ac150 genes of Autographa californica multiple nucleopolyhedrovirus (AcMNPV)...
  48. Matindoost L, Nielsen L, Reid S. Intracellular Trafficking of Baculovirus Particles: A Quantitative Study of the HearNPV/HzAM1 Cell and AcMNPV/Sf9 Cell Systems. Viruses. 2015;7:2288-307 pubmed publisher
    ..the baculovirus traffic in subcellular fractions of host cells throughout infection with an emphasis on AcMNPV/Sf9 and HearNPV/HzAM1 systems distinguished as "good" and "bad" BV producers, respectively...
  49. Ren H, Hu Y, Guo Y, Li L. Plutella xylostella granulovirus late gene promoter activity in the context of the Autographa californica multiple nucleopolyhedrovirus genome. Virol Sin. 2016;31:229-39 pubmed publisher
    ..into a transient expression vector and the alphabaculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) genome, and compared with homologous late gene promoters of AcMNPV in Sf9 cells...
  50. Hodgson J, Arif B, Krell P. Autographa californica multiple nucleopolyhedrovirus and Choristoneura fumiferana multiple nucleopolyhedrovirus v-cath genes are expressed as pre-proenzymes. J Gen Virol. 2009;90:995-1000 pubmed publisher
    ..The cathepsins of Autographa californica multiple nucleopolyhedrovirus (AcMNPV), Choristoneura fumiferana multiple nucleopolyhedrovirus (CfMNPV) and most other alphabaculovirus group I ..
  51. Zhang Y, Hu X, Mu J, Hu Y, Zhou Y, Zhao H, et al. Ac102 Participates in Nuclear Actin Polymerization by Modulating BV/ODV-C42 Ubiquitination during Autographa californica Multiple Nucleopolyhedrovirus Infection. J Virol. 2018;92: pubmed publisher
    ..NPF), P78/83 induces actin polymerization to assist in Autographa californica multiple nucleopolyhedrovirus (AcMNPV) propagation...
  52. Maegawa K, Shibata T, Yamaguchi R, Hiroike K, Izzati U, Kuroda K, et al. Overexpression of a virus-like particle influenza vaccine in Eri silkworm pupae, using Autographa californica nuclear polyhedrosis virus and host-range expansion. Arch Virol. 2018;163:2787-2797 pubmed publisher
    ..BmNPV), which is unable to replicate in Sf9 cells from Eri silkworms, was replaced with the Autographa californica nuclear polyhedrosis virus (AcNPV) vector, three improved AcNPV influenza virus recombinants capable of replication in ..
  53. Tachibana A, Hamajima R, Tomizaki M, Kondo T, Nanba Y, Kobayashi M, et al. HCF-1 encoded by baculovirus AcMNPV is required for productive nucleopolyhedrovirus infection of non-permissive Tn368 cells. Sci Rep. 2017;7:3807 pubmed publisher
    Baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) replicates in both Spodoptera frugiperda Sf21 and Trichoplusia ni Tn368 cells, whereas AcMNPV defective in hcf-1 (host cell-factor 1) gene productively infects only ..
  54. Ohkawa T, Welch M. Baculovirus Actin-Based Motility Drives Nuclear Envelope Disruption and Nuclear Egress. Curr Biol. 2018;28:2153-2159.e4 pubmed publisher
    ..The type species Autographa californica M nucleopolyhedrovirus (AcMNPV) shares with other pathogens an ability to assemble host actin monomers (G-actin) into actin filaments (F-actin) ..
  55. Hosamani M, Basagoudanavar S, Sreenivasa B, Inumaru S, Ballal C, Venkataramanan R. Eri silkworm (Samia ricini), a non-mulberry host system for AcMNPV mediated expression of recombinant proteins. J Biotechnol. 2015;216:76-81 pubmed publisher
    The baculovirus expression system (BVES) based on Autographa californica nucleopolyhedrovirus (AcMNPV) is widely used for the expression of eukaryotic proteins...
  56. Kato T, Itagaki K, Yoshimoto M, Hiramatsu R, Suhaimi H, Kohsaka T, et al. Transduction of a Neospora caninum antigen gene into mammalian cells using a modified Bombyx mori nucleopolyhedrovirus for antibody production. J Biosci Bioeng. 2017;124:606-610 pubmed publisher
    Autographa californica multiple nucleopolyhedrovirus (AcMNPV) can easily enter and transduce foreign genes into mammalian cells, but these functions are difficult for Bombyx mori nucleopolyhedrovirus (BmNPV)...
  57. Liu Y, de Jong J, Nagy Ã, Theilmann D, Krell P. Nuclear Translocation Sequence and Region in Autographa californica Multiple Nucleopolyhedrovirus ME53 That Are Important for Optimal Baculovirus Production. J Virol. 2016;90:3953-3965 pubmed publisher
    Autographa californicamultiple nucleopolyhedrovirus (AcMNPV) is in the familyBaculoviridae, genusAlphabaculovirus AcMNPVme53is a highly conserved immediate early gene in all lepidopteran baculoviruses that have been sequenced and is ..
  58. Zhang X, Xu K, Ou Y, Xu X, Chen H. Development of a baculovirus vector carrying a small hairpin RNA for suppression of sf-caspase-1 expression and improvement of recombinant protein production. BMC Biotechnol. 2018;18:24 pubmed publisher
    ..Sf-caspase-1) were constructed and inserted into an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) vector...
  59. Liang C, Lan D, Zhao S, Liu L, Xue Y, Zhang Y, et al. The Ac124 protein is not essential for the propagation of Autographa californica multiple nucleopolyhedrovirus, but it is a viral pathogenicity factor. Arch Virol. 2015;160:275-84 pubmed publisher
    orf124 (ac124) of AcMNPV is one of the highly conserved unique genes in group I lepidopteran nucleopolyhedroviruses. So far, its function remains unknown...
  60. Wang H, Meng T, Wei W. Analysis of synonymous codon usage bias in helicase gene from Autographa californica multiple nucleopolyhedrovirus. Genes Genomics. 2018;40:767-780 pubmed publisher
    The helicase gene of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is not only involved in viral DNA replication, but also plays a role in viral host range...
  61. Bossert M, Carstens E. Sequential deletion of AcMNPV homologous regions leads to reductions in budded virus production and late protein expression. Virus Res. 2018;256:125-133 pubmed publisher
    ..Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) carries eight hrs...
  62. Sampieri A, Luz Madrigal A, Zepeda J, Vaca L. Identification of fragments from Autographa californica polyhedrin protein essential for self-aggregation and exogenous protein incorporation. BMC Biochem. 2015;16:5 pubmed publisher
    ..on the crystal structure of polyhedrin, we conducted an in silico analysis of the baculovirus Autographa californica nucleopolyhedrovirus (AcMNPV) polyhedrin protein to select the minimum fragments of polyhedrin that could be ..
  63. Kokusho R, Kawamoto M, Koyano Y, Sugano S, Suzuki Y, Shimada T, et al. Bombyx mori nucleopolyhedrovirus actin rearrangement-inducing factor 1 enhances systemic infection in B. mori larvae. J Gen Virol. 2015;96:1938-46 pubmed publisher
    ..Previous studies reported that Autographa californica nucleopolyhedrovirus ARIF-1 protein induces filamentous actin concentration on the plasma membrane during the early ..
  64. Yu Q, Blissard G, Liu T, Li Z. Autographa californica multiple nucleopolyhedrovirus GP64 protein: Analysis of domain I and V amino acid interactions and membrane fusion activity. Virology. 2016;488:259-70 pubmed publisher
  65. Chen G, Fang Y, Wu L, Yan Q, Krell P, Feng G. A betabaculovirus DNA polymerase cannot substitute for the DNA polymerase of the alphabaculovirus Autographa californica nucleopolyhedrovirus. Arch Virol. 2017;162:3487-3492 pubmed publisher
    ..substitute for the DNApol of a group I alphabaculovirus, Autographa californica multiple nucleopolyhedrovirus (AcMNPV). However, it is not known if a betabaculovirus DNApol could subsititute for the alphabaculovirus DNApol in AcMNPV...
  66. Chen Y, Zhong S, Fei Z, Gao S, Zhang S, Li Z, et al. Transcriptome responses of the host Trichoplusia ni to infection by the baculovirus Autographa californica multiple nucleopolyhedrovirus. J Virol. 2014;88:13781-97 pubmed publisher
    ..infection of Trichoplusia ni cells by the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) leads to expression of ~156 viral genes and results in dramatic cell remodeling...
  67. Lyupina Y, Zatsepina O, Serebryakova M, Erokhov P, Abaturova S, Kravchuk O, et al. Proteomics of the 26S proteasome in Spodoptera frugiperda cells infected with the nucleopolyhedrovirus, AcMNPV. Biochim Biophys Acta. 2016;1864:738-746 pubmed publisher
    ..frugiperda (Sf9), cells in the course of infection with the Autographa californica multiple nucleopolyhedrovirus (AcMNPV)...
  68. Biswas S, Blissard G, Theilmann D. Trichoplusia ni Kinesin-1 Associates with Autographa californica Multiple Nucleopolyhedrovirus Nucleocapsid Proteins and Is Required for Production of Budded Virus. J Virol. 2016;90:3480-95 pubmed publisher
    The mechanism by which nucleocapsids of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) egress from the nucleus to the plasma membrane, leading to the formation of budded virus (BV), is not known...
  69. Chen G, Yan Q, Fang Y, Wu L, Krell P, Feng G. The N Terminus of Autographa californica Multiple Nucleopolyhedrovirus DNA Polymerase Is Required for Efficient Viral DNA Replication and Virus and Occlusion Body Production. J Virol. 2018;92: pubmed publisher
    Autographa californica multiple nucleopolyhedrovirus (AcMNPV) DNA polymerase (DNApol) plays a crucial role in viral DNA synthesis, and the N terminus (residues 1 to 186) is highly conserved in the baculovirus DNApol family...
  70. Yu Q, Xiong Y, Liu J, Wang Q, Qiu Y, Wen D. Comparative proteomics analysis of apoptotic Spodoptera frugiperda cells during p35 knockout Autographa californica multiple nucleopolyhedrovirus infection. Comp Biochem Physiol Part D Genomics Proteomics. 2016;18:21-9 pubmed publisher
    Infection with Autographa californica multiple nucleopolyhedrovirus (AcMNPV) mutants lacking a functional p35 gene can induce host cell apoptosis, which provides the possibility to use the potential of these viruses in the biological ..
  71. Cao L, Li X, Zheng S, Liang A, Fu Y. SfP53 and filamentous actin (F-actin) are the targets of viral pesticide AcMNPV-BmK IT (P10/PH) in host Spodoptera frugiperda 9 cells. Biotechnol Lett. 2016;38:2059-2069 pubmed
    To analyze the anti-insect mechanism of viral pesticide AcMNPV-BmK IT(P10/PH) in the host Spodoptera frugiperda 9 (Sf9) cells...
  72. Hepp S, Borgo G, Ticau S, Ohkawa T, Welch M. Baculovirus AC102 Is a Nucleocapsid Protein That Is Crucial for Nuclear Actin Polymerization and Nucleocapsid Morphogenesis. J Virol. 2018;92: pubmed publisher
    The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), the type species of alphabaculoviruses, is an enveloped DNA virus that infects lepidopteran insects and is commonly known as a vector for protein expression ..
  73. Katsuma S. Phosphatase activity of Bombyx mori nucleopolyhedrovirus PTP is dispensable for enhanced locomotory activity in B. mori larvae. J Invertebr Pathol. 2015;132:228-32 pubmed publisher
    ..with a mutant Bombyx mori nucleopolyhedrovirus (BmNPV) or Autographa californica multiple nucleopolyhedrovirus (AcMNPV) lacking a functional protein tyrosine phosphatase gene (ptp)...
  74. Li Y, Shen S, Hu L, Deng F, Vlak J, Hu Z, et al. The Functional Oligomeric State of Tegument Protein GP41 Is Essential for Baculovirus Budded Virion and Occlusion-Derived Virion Assembly. J Virol. 2018;92: pubmed publisher
    ..A previous study using a temperature-sensitive Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) mutant showed that GP41 plays a crucial role in budded virion (BV) formation...
  75. Ali M, Kato T, Park E. Improved insecticidal activity of a recombinant baculovirus expressing spider venom cyto-insectotoxin. Appl Microbiol Biotechnol. 2015;99:10261-9 pubmed publisher
    ..recombinant Bombyx mori nucleopolyhedrovirus (BmNPV) and an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) that expressed an insect-specific cyto-insectotoxin (Cit1a) from the venom of the central Asian spider Lachesana ..
  76. Ke X, Zhang Y, Liu Y, Wang H. Identification of AcMNPV GP64-binding proteins through a combinational use of a self-biotinylated virus and the cross-linking method. Biochem Biophys Res Commun. 2015;467:760-5 pubmed publisher
    ..In this study, we developed a self-biotinylated AcMNPV bearing biotinylated GP64 glycoproteins...
  77. Fu Y, Lin T, Liang A, Hu F. Effects of recombinant baculovirus AcMNPV-BmK IT on the formation of early cables and nuclear polymerization of actin in Sf9 cells. Cytotechnology. 2016;68:381-7 pubmed publisher
    Autographa californica nuclearpoly hedrosis virus (AcMNPV) is one of the most important baculoviridae. However, the application of AcMNPV as a biocontrol agent has been limited...
  78. Nishigami M, Mori T, Tomita M, Takiguchi K, Tsumoto K. Membrane fusion between baculovirus budded virus-enveloped particles and giant liposomes generated using a droplet-transfer method for the incorporation of recombinant membrane proteins. Colloids Surf B Biointerfaces. 2017;155:248-256 pubmed publisher
    ..interfaces to form enclosed bilayer vesicles, and ii) budded viruses (BVs) of baculovirus (Autographa californica nucleopolyhedrovirus) that express recombinant transmembrane proteins on their envelopes...
  79. Xu J, Zhang P, Kusakabe T, Mon H, Li Z, Zhu L, et al. Comparative proteomic analysis of hemolymph proteins from Autographa californica multiple nucleopolyhedrovirus (AcMNPV)-sensitive or -resistant silkworm strains during infections. Comp Biochem Physiol Part D Genomics Proteomics. 2015;16:36-47 pubmed publisher
    We reported previously that baculovirus AcMNPV host-ranges in silkworm strains are controlled by a novel third chromosomal locus...
  80. Wu Y, Wu C, Huang Y, Huang S, Lo H, Chang H, et al. Identification of a high-efficiency baculovirus DNA replication origin that functions in insect and mammalian cells. J Virol. 2014;88:13073-85 pubmed publisher
    The p143 gene from Autographa californica multinucleocapsid nucleopolyhedrovirus (AcMNPV) has been found to increase the expression of luciferase, which is driven by the polyhedrin gene promoter, in a plasmid with virus coinfection...
  81. Garretson T, McCoy J, Cheng X. Baculovirus FP25K Localization: Role of the Coiled-Coil Domain. J Virol. 2016;90:9582-9597 pubmed publisher
    ..Previously, FP25K from the model alphabaculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) was shown to traffic ODV envelope proteins. However, FP25K localization and the domains involved are inconclusive...
  82. Hodgson J, Arif B, Krell P. Interaction of Autographa californica multiple nucleopolyhedrovirus cathepsin protease progenitor (proV-CATH) with insect baculovirus chitinase as a mechanism for proV-CATH cellular retention. J Virol. 2011;85:3918-29 pubmed publisher
    ..demonstrate that the amino-terminal 22 amino acids (aa) of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) preproV-CATH are responsible for the entry of proV-CATH into the ER...
  83. Chen L, Yang R, Hu X, Xiang X, Yu S, Wu X. The formation of occlusion-derived virus is affected by the expression level of ODV-E25. Virus Res. 2013;173:404-14 pubmed publisher
    ..These results indicated that the formation occlusion-derived virus was affected by the expression level of ODV-E25. ..
  84. Meng X, Zheng G, Zhao C, Wan F, Li C. A cell clone strain from Mythimna separata (Lepidoptera: Noctuidae) highly susceptible to Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and M. separata NPV (MsNPV). In Vitro Cell Dev Biol Anim. 2017;53:646-650 pubmed publisher
    ..Ms-10C was more sensitive than Ms-10 to both Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and M. separata nucleopolyhedrovirus (MsNPV)...
  85. Javed M, Harris S, Willis L, Theilmann D, Donly B, Erlandson M, et al. Microscopic investigation of AcMNPV infection in the Trichoplusia ni midgut. J Invertebr Pathol. 2016;141:24-33 pubmed publisher
    Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is the type species for the genus Alphabaculovirus in the family Baculoviridae...
  86. Wei L, Cao L, Miao Y, Wu S, Xu S, Wang R, et al. Transcriptome analysis of Spodoptera frugiperda 9 (Sf9) cells infected with baculovirus, AcMNPV or AcMNPV-BmK IT. Biotechnol Lett. 2017;39:1129-1139 pubmed publisher
    To analyze the transcriptome of Spodoptera frugiperda 9 (Sf9) cells infected with AcMNPV or AcMNPV-BmK IT. A comprehensive transcriptome profile for Sf9 cells infected with AcMNPV or AcMNPV-BmK IT is shown...
  87. Guo Y, Yue Q, Gao J, Wang Z, Chen Y, Blissard G, et al. Roles of Cellular NSF Protein in Entry and Nuclear Egress of Budded Virions of Autographa californica Multiple Nucleopolyhedrovirus. J Virol. 2017;91: pubmed publisher
    ..Upon infection of insect cells by the virus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), the transcript levels of most SNARE genes initially were upregulated...
  88. Marek M, Romier C, Galibert L, Merten O, van Oers M. Baculovirus VP1054 is an acquired cellular PUR?, a nucleic acid-binding protein specific for GGN repeats. J Virol. 2013;87:8465-80 pubmed publisher
    ..Deletion of the Autographa californica multiple nucleopolyhedrovirus (AcMNPV) vp1054 gene completely prevented viral cell-to-cell spread...
  89. Miao Y, Liang A, Fu Y. Baculovirus antiapoptotic protein P35 regulated the host apoptosis to enhance virus multiplication. Mol Cell Biochem. 2016;423:67-73 pubmed
    The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) possesses p35 gene, which encodes antiapoptosis protein P35 (or Ac-P35)...
  90. Kawaguchi Y, Sugiura N, Onishi M, Kimata K, Kimura M, Kakuta Y. Crystallization and X-ray diffraction analysis of chondroitin lyase from baculovirus: envelope protein ODV-E66. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:190-2 pubmed publisher
    ..8 Å resolution and belonged to space group P6(2) or P6(4), with unit-cell parameters a = b = 113.5, c = 101.5 Å. One molecule is assumed to be present per asymmetric unit, which gives a Matthews coefficient of 2.54 Å(3) Da(-1). ..
  91. Huang Z, Pan M, Zhu S, Zhang H, Wu W, Yuan M, et al. The Autographa californica Multiple Nucleopolyhedrovirus ac83 Gene Contains a cis-Acting Element That Is Essential for Nucleocapsid Assembly. J Virol. 2017;91: pubmed publisher
    ..studies have shown that deletion of the ac83 gene of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) blocks viral nucleocapsid assembly...
  92. Qiu J, Tang Z, Yuan M, Wu W, Yang K. The 91-205 amino acid region of AcMNPV ORF34 (Ac34), which comprises a potential C3H zinc finger, is required for its nuclear localization and optimal virus multiplication. Virus Res. 2017;228:79-89 pubmed publisher
    ..Autographa californica multiple nucleopolyhedrovirus (AcMNPV) orf34 (ac34) is an alphabaculovirus unique gene that is required for optimal virus production...