Thermotoga maritima MSB8

Summary

Alias: Thermotoga maritima DSM 3109, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8

Top Publications

  1. Agrawal R, Linde J, Sengupta J, Nierhaus K, Frank J. Localization of L11 protein on the ribosome and elucidation of its involvement in EF-G-dependent translocation. J Mol Biol. 2001;311:777-87 pubmed
    ..The results provide a new insight into the mechanism of EF-G-dependent translocation. ..
  2. Thompson J, Cundliffe E, Stark M. Binding of thiostrepton to a complex of 23-S rRNA with ribosomal protein L11. Eur J Biochem. 1979;98:261-5 pubmed
    ..coli or the homologous protein BM-L11 of Bacillus megaterium. In the presence of T1 ribonuclease, protein BM-L11 and thiostrepton protect from degradation a fragment of E. coli 23-S RNA estimated to be about 50 nucleotides in length. ..
  3. Xing Y, Draper D. Cooperative interactions of RNA and thiostrepton antibiotic with two domains of ribosomal protein L11. Biochemistry. 1996;35:1581-8 pubmed
    ..L11 function is thus more complex than simple interaction with ribosomal RNA; we suggest that thiostrepton mimics some ribosomal component or factor that normally interacts with the L11 N-terminal domain. ..
  4. Conn G, Draper D, Lattman E, Gittis A. Crystal structure of a conserved ribosomal protein-RNA complex. Science. 1999;284:1171-4 pubmed
    ..This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome. ..
  5. Wimberly B, Brodersen D, Clemons W, Morgan Warren R, Carter A, Vonrhein C, et al. Structure of the 30S ribosomal subunit. Nature. 2000;407:327-39 pubmed
    ..The structure will facilitate the interpretation in molecular terms of lower resolution structural data on several functional states of the ribosome from electron microscopy and crystallography. ..
  6. Singleton M, Scaife S, Wigley D. Structural analysis of DNA replication fork reversal by RecG. Cell. 2001;107:79-89 pubmed
    ..We propose a mechanism for how forks are processed by RecG to facilitate replication fork restart. In addition, this structure suggests that the mechanism and function of the two largest helicase superfamilies are distinct. ..
  7. Valle M, Zavialov A, Li W, Stagg S, Sengupta J, Nielsen R, et al. Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy. Nat Struct Biol. 2003;10:899-906 pubmed
    ..From these new findings we propose a mechanism that can explain the sequence of events during the decoding of mRNA on the ribosome. ..
  8. Evans J, Huddler D, Hilgers M, Romanchuk G, Matthews R, Ludwig M. Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase. Proc Natl Acad Sci U S A. 2004;101:3729-36 pubmed
    ..To complete the catalytic cycle, the cobalamin-binding domain must travel back and forth between these distant active sites. ..
  9. DiDonato M, Krishna S, Schwarzenbacher R, McMullan D, Jaroszewski L, Miller M, et al. Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 A resolution. Proteins. 2006;63:256-60 pubmed

More Information

Publications152 found, 100 shown here

  1. Lunin V, Dobrovetsky E, Khutoreskaya G, Zhang R, Joachimiak A, Doyle D, et al. Crystal structure of the CorA Mg2+ transporter. Nature. 2006;440:833-7 pubmed
    ..An apparent Mg2+ ion was bound between monomers at a conserved site in the cytoplasmic domain, suggesting a mechanism to link gating of the pore to the intracellular concentration of Mg2+. ..
  2. Morar M, Anand R, Hoskins A, Stubbe J, Ealick S. Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. Biochemistry. 2006;45:14880-95 pubmed
  3. Kim T, Heo S, Ku J, Ban C. Functional properties of the thermostable mutL from Thermotoga maritima. BMB Rep. 2009;42:53-8 pubmed
    ..The properties of a stable MutL homologue were investigated using a thermostable MutL (TmL) from Thermotoga maritima MSB8 and whose size exclusion chromatographic and crosslinking analyses were compatible with a dimeric form of ..
  4. Bilwes A, Alex L, Crane B, Simon M. Structure of CheA, a signal-transducing histidine kinase. Cell. 1999;96:131-41 pubmed
    ..Different subunit conformations suggest that relative domain motions link receptor response to kinase activity. ..
  5. Agrawal R, Heagle A, Penczek P, Grassucci R, Frank J. EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome. Nat Struct Biol. 1999;6:643-7 pubmed
    ..Upon GTP hydrolysis, the bifurcation is reversed and an arc-like connection is formed between the base of the stalk and EF-G. ..
  6. Quezada C, Gradinaru C, Simon M, Bilwes A, Crane B. Helical shifts generate two distinct conformers in the atomic resolution structure of the CheA phosphotransferase domain from Thermotoga maritima. J Mol Biol. 2004;341:1283-94 pubmed
    ..The P1 conformations that we observe are likely relevant to other helical or coiled-coil proteins and may be important for generating switches in signaling processes. ..
  7. Eshaghi S, Niegowski D, Kohl A, Martinez Molina D, Lesley S, Nordlund P. Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution. Science. 2006;313:354-7 pubmed
  8. Mueller F, Sommer I, Baranov P, Matadeen R, Stoldt M, Wöhnert J, et al. The 3D arrangement of the 23 S and 5 S rRNA in the Escherichia coli 50 S ribosomal subunit based on a cryo-electron microscopic reconstruction at 7.5 A resolution. J Mol Biol. 2000;298:35-59 pubmed
  9. Lentzen G, Klinck R, Matassova N, Aboul ela F, Murchie A. Structural basis for contrasting activities of ribosome binding thiazole antibiotics. Chem Biol. 2003;10:769-78 pubmed
    ..We have generated a three-dimensional (3D) model for the interaction of thiostrepton with L11BD RNA. The model rationalizes the differences between micrococcin and the thiostrepton-like antibiotics interacting with L11BD. ..
  10. Mathews I, Krishna S, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, et al. Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution. Proteins. 2006;63:1106-11 pubmed
  11. Mathews I, Krishna S, Schwarzenbacher R, McMullan D, Jaroszewski L, Miller M, et al. Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 A resolution. Proteins. 2006;65:249-54 pubmed
  12. Wimberly B, Guymon R, McCutcheon J, White S, Ramakrishnan V. A detailed view of a ribosomal active site: the structure of the L11-RNA complex. Cell. 1999;97:491-502 pubmed
    ..These antibiotics are proposed to bind in this cleft, locking the putative switch and interfering with the function of elongation factors...
  13. Petry S, Brodersen D, Murphy F, Dunham C, Selmer M, Tarry M, et al. Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon. Cell. 2005;123:1255-66 pubmed publisher
    ..Finally, this work demonstrates the feasibility of crystallizing ribosomes with bound factors at a defined state along the translational pathway...
  14. Payandeh J, Pai E. A structural basis for Mg2+ homeostasis and the CorA translocation cycle. EMBO J. 2006;25:3762-73 pubmed publisher
    ..A proteolytic protection assay, biophysical data, and comparison to a soluble domain structure from Archaeoglobus fulgidus have revealed the potential reaction coordinate for this diverse family of transport proteins...
  15. Bale S, Baba K, McCloskey D, Pegg A, Ealick S. Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity. Acta Crystallogr D Biol Crystallogr. 2010;66:181-9 pubmed publisher
    ..The conservation of the ligand-binding mode and the active-site residues between human and T. maritima AdoMetDC provides insight into the evolution of AdoMetDC. ..
  16. Bhatnagar J, Borbat P, Pollard A, Bilwes A, Freed J, Crane B. Structure of the ternary complex formed by a chemotaxis receptor signaling domain, the CheA histidine kinase, and the coupling protein CheW as determined by pulsed dipolar ESR spectroscopy. Biochemistry. 2010;49:3824-41 pubmed publisher
    ..In the context of the hexagonal lattice formed by trimeric transmembrane chemoreceptors, the PDS structure is best accommodated with the P3 domain in the center of a honeycomb edge...
  17. Mohanty B, Serrano P, Pedrini B, Jaudzems K, Geralt M, Horst R, et al. Comparison of NMR and crystal structures for the proteins TM1112 and TM1367. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:1381-92 pubmed publisher
    ..m.s.d. values calculated either for the polypeptide backbone, the core residues with solvent accessibility below 15% or all heavy atoms. ..
  18. Bakolitsa C, Schwarzenbacher R, McMullan D, Brinen L, Canaves J, Dai X, et al. Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold. Proteins. 2004;56:607-10 pubmed
  19. Penhoat C, Li Z, Atreya H, Kim S, Yee A, Xiao R, et al. NMR solution structure of Thermotoga maritima protein TM1509 reveals a Zn-metalloprotease-like tertiary structure. J Struct Funct Genomics. 2005;6:51-62 pubmed publisher
    ..This suggests that protein family UPF0054 might contain members of a hitherto uncharacterized class of metalloproteases...
  20. Cicmil N. Crystallization and preliminary X-ray crystallographic characterization of TrmFO, a folate-dependent tRNA methyltransferase from Thermotoga maritima. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:193-5 pubmed publisher
    ..0 at 291 K using the hanging-drop vapor-diffusion method. The plate-shaped crystals diffracted to 2.6 A and belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 79.94, b = 92.46, c = 127.20 A. ..
  21. Sanangelantoni A, Bocchetta M, Cammarano P, Tiboni O. Phylogenetic depth of S10 and spc operons: cloning and sequencing of a ribosomal protein gene cluster from the extremely thermophilic bacterium Thermotoga maritima. J Bacteriol. 1994;176:7703-10 pubmed
  22. Gruber T, Bryant D. Molecular systematic studies of eubacteria, using sigma70-type sigma factors of group 1 and group 2. J Bacteriol. 1997;179:1734-47 pubmed
    ..The data suggest that promoters recognized by the major vegetative sigma factors of eubacteria will contain sequence motifs and spacing very similar to those for the sigma70 sigma factors of Escherichia coli...
  23. Guipaud O, Labedan B, Forterre P. A gyrB-like gene from the hyperthermophilic bacterion Thermotoga maritima. Gene. 1996;174:121-8 pubmed
    ..No gyrA-like gene has been found near top2B. A gene coding for a transaminase B-like protein was found in the upstream region of top2B. ..
  24. Liebl W, Wagner B, Schellhase J. Properties of an alpha-galactosidase, and structure of its gene galA, within an alpha-and beta-galactoside utilization gene cluster of the hyperthermophilic bacterium Thermotoga maritima. Syst Appl Microbiol. 1998;21:1-11 pubmed
    ..Its extreme thermal stability (t 1/2 = 6.5 h at 85 degrees C) makes this enzyme an interesting candidate for biotechnological applications...
  25. Rawat U, Gao H, Zavialov A, Gursky R, Ehrenberg M, Frank J. Interactions of the release factor RF1 with the ribosome as revealed by cryo-EM. J Mol Biol. 2006;357:1144-53 pubmed publisher
    ..Very recent data obtained with small-angle X-ray scattering now reveal that the solution structure of RF1 is open, as here seen on the ribosome by cryo-EM, and not closed, as seen in the crystal...
  26. Mathews I, Deacon A, Canaves J, McMullan D, Lesley S, Agarwalla S, et al. Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein. Structure. 2003;11:677-90 pubmed
    ..We have identified a new helix-loop-strand FAD binding motif characteristic of the enzymes in the TSCP family. The presence of a hydrophobic core with residues conserved among the TSCP family suggests a common overall fold...
  27. Schwarzenbacher R, von Delft F, Abdubek P, Ambing E, Biorac T, Brinen L, et al. Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 A resolution. Proteins. 2004;54:810-3 pubmed
  28. Meissner H, Liebl W. Thermotoga maritima maltosyltransferase, a novel type of maltodextrin glycosyltransferase acting on starch and malto-oligosaccharides. Eur J Biochem. 1998;258:1050-8 pubmed
    ..The non-hydrolytic enzyme, designated maltosyltransferase (MTase), of the hyperthermophilic bacterium Thermotoga maritima MSB8 disproportionates malto-oligosaccharides via glycosyl transfer reactions...
  29. Chen Y, Bauer B, Rapoport T, GUMBART J. Conformational Changes of the Clamp of the Protein Translocation ATPase SecA. J Mol Biol. 2015;427:2348-59 pubmed publisher
    ..Mutational disruption of clamp opening or closure abolishes protein translocation. These results suggest how conformational changes of SecA allow substrate binding and movement during protein translocation. ..
  30. Hermann J, Marti Arbona R, Fedorov A, Fedorov E, Almo S, Shoichet B, et al. Structure-based activity prediction for an enzyme of unknown function. Nature. 2007;448:775-9 pubmed publisher
    ..maritima in a previously uncharacterized SAH degradation pathway. Structure-based docking with high-energy forms of potential substrates may be a useful tool to annotate enzymes for function...
  31. Im D, Kimura K, Hayasaka F, Tanaka T, Noguchi M, Kobayashi A, et al. Crystal structures of glycoside hydrolase family 51 ?-L-arabinofuranosidase from Thermotoga maritima. Biosci Biotechnol Biochem. 2012;76:423-8 pubmed
    ..Possible substrate binding modes were investigated by automated docking analysis. ..
  32. Toth E, Yeates T. The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway. Structure. 2000;8:163-74 pubmed
    ..Modeling of the pathogenic human S413P mutation indicates that the mutation destabilizes the enzyme by disrupting the C-terminal extension...
  33. Forse G, Ram N, Banatao D, Cascio D, Sawaya M, Klock H, et al. Synthetic symmetrization in the crystallization and structure determination of CelA from Thermotoga maritima. Protein Sci. 2011;20:168-78 pubmed publisher
    ..The results support the notion that synthetic symmetrization can be a useful approach for enlarging the search space for crystallizing monomeric proteins or asymmetric complexes. ..
  34. Huang Y, Ito J. The hyperthermophilic bacterium Thermotoga maritima has two different classes of family C DNA polymerases: evolutionary implications. Nucleic Acids Res. 1998;26:5300-9 pubmed
    ..These results are in conflict with 16S rRNA-based phylogenies, which placed T.maritima as one of the deepest branches of the bacterial tree...
  35. Griswold I, Zhou H, Matison M, Swanson R, McIntosh L, Simon M, et al. The solution structure and interactions of CheW from Thermotoga maritima. Nat Struct Biol. 2002;9:121-5 pubmed publisher
    ..These results provide a structural basis for a model in which CheW acts as a molecular bridge between CheA and the cytoplasmic tails of the receptor...
  36. Iida T, Inatomi K, Kamagata Y, Maruyama T. F- and V-type ATPases in the hyperthermophilic bacterium Thermotoga neapolitana. Extremophiles. 2002;6:369-75 pubmed
    ..maritima genome. Evolution of the two types of ATPases in Thermotoga is discussed. ..
  37. Lycklama A Nijeholt J, Bulacu M, Marrink S, Driessen A. Immobilization of the plug domain inside the SecY channel allows unrestricted protein translocation. J Biol Chem. 2010;285:23747-54 pubmed publisher
    ..Biochemical characterization of this mutant as well as molecular dynamics simulations suggest that only a limited movement of the plug domain suffices for translocation...
  38. Sircar R, Greenswag A, Bilwes A, Gonzalez Bonet G, Crane B. Structure and activity of the flagellar rotor protein FliY: a member of the CheC phosphatase family. J Biol Chem. 2013;288:13493-502 pubmed publisher
    ..A putative N-terminal CheY binding domain conserved with FliM is not required for binding CheY-P or phosphatase activity...
  39. Ausili A, Pennacchio A, Staiano M, Dattelbaum J, Fessas D, Schiraldi A, et al. Amino acid transport in thermophiles: characterization of an arginine-binding protein from Thermotoga maritima. 3. Conformational dynamics and stability. J Photochem Photobiol B. 2013;118:66-73 pubmed publisher
    ..The obtained results are discussed in combination with a detailed inspection of the three-dimensional structure of the protein. ..
  40. Chakladar S, Wang Y, Clark T, Cheng L, Ko S, Vocadlo D, et al. A mechanism-based inactivator of glycoside hydrolases involving formation of a transient non-classical carbocation. Nat Commun. 2014;5:5590 pubmed publisher
    ..1.0]heptyl analogue of galactose differ by only a factor of 20. This inactivator has the potential for further development as a useful biological research tool for both basic research and biotechnological applications. ..
  41. Wahl M, Bourenkov G, Bartunik H, Huber R. Flexibility, conformational diversity and two dimerization modes in complexes of ribosomal protein L12. EMBO J. 2000;19:174-86 pubmed publisher
    ..The structures have been submitted to the Protein Databank (http://www.rcsb.org/pdb) under accession numbers 1DD3 and 1DD4...
  42. van den Ent F, Amos L, L we J. Prokaryotic origin of the actin cytoskeleton. Nature. 2001;413:39-44 pubmed publisher
    ..Thus, prokaryotes are now known to possess homologues both of tubulin, namely FtsZ, and of actin...
  43. Savchenko A, Skarina T, Evdokimova E, Watson J, Laskowski R, Arrowsmith C, et al. X-ray crystal structure of CutA from Thermotoga maritima at 1.4 A resolution. Proteins. 2004;54:162-5 pubmed
  44. Bonin I, Robelek R, Benecke H, Urlaub H, Bacher A, Richter G, et al. Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding. Biochem J. 2004;383:419-28 pubmed publisher
    ..Therefore, in certain organisms, dimerization may be employed to package NusB in an inactive form until recruitment into antitermination complexes...
  45. Miyazaki K. Hyperthermophilic alpha-L: -arabinofuranosidase from Thermotoga maritima MSB8: molecular cloning, gene expression, and characterization of the recombinant protein. Extremophiles. 2005;9:399-406 pubmed
    ..AFase) gene belonging to family 51 of glycosyl hydrolases of a hyperthermophilic bacterium Thermotoga maritima MSB8 was cloned, sequenced, and overexpressed in Escherichia coli...
  46. Diaconu M, Kothe U, Schl nzen F, Fischer N, Harms J, Tonevitsky A, et al. Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation. Cell. 2005;121:991-1004 pubmed publisher
    ..Highly mobile L7/12 C-terminal domains promote recruitment of translation factors to the ribosome and stimulate GTP hydrolysis by the ribosome bound factors through stabilization of their active GTPase conformation...
  47. Xu Q, Krishna S, McMullan D, Schwarzenbacher R, Miller M, Abdubek P, et al. Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p. Proteins. 2006;65:777-82 pubmed
  48. Usher K, de la Cruz A, Dahlquist F, Swanson R, Simon M, Remington S. Crystal structures of CheY from Thermotoga maritima do not support conventional explanations for the structural basis of enhanced thermostability. Protein Sci. 1998;7:403-12 pubmed publisher
  49. Sivaraman J, Li Y, Larocque R, Schrag J, Cygler M, Matte A. Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate. J Mol Biol. 2001;311:761-76 pubmed
    ..We propose that the tetrahedral complex has resulted from non-productive binding of l-histidinol phosphate soaked into the HisC crystals, resulting in its inability to be converted to the external aldimine at the HisC active site...
  50. Johnsen U, Hansen T, Schonheit P. Comparative analysis of pyruvate kinases from the hyperthermophilic archaea Archaeoglobus fulgidus, Aeropyrum pernix, and Pyrobaculum aerophilum and the hyperthermophilic bacterium Thermotoga maritima: unusual regulatory properties in hyperthermophil. J Biol Chem. 2003;278:25417-27 pubmed publisher
    ..Phylogenetic analysis of PK sequences of all three domains indicates a distinct archaeal cluster that includes the PK from the hyperthermophilic bacterium T. maritima...
  51. Kazantsev A, Krivenko A, Harrington D, Carter R, Holbrook S, Adams P, et al. High-resolution structure of RNase P protein from Thermotoga maritima. Proc Natl Acad Sci U S A. 2003;100:7497-502 pubmed publisher
    ..The protein is found to dimerize through an extensive, well-ordered interface. This dimerization may reflect a mechanism of thermal stability of the protein before assembly with the RNA moiety of the holoenzyme...
  52. Xu Q, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Biorac T, et al. Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold. Proteins. 2005;58:976-81 pubmed
  53. Mathews I, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Axelrod H, et al. Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold. Proteins. 2005;59:869-74 pubmed publisher
  54. Almeida M, Herrmann T, Peti W, Wilson I, Wuthrich K. NMR structure of the conserved hypothetical protein TM0487 from Thermotoga maritima: implications for 216 homologous DUF59 proteins. Protein Sci. 2005;14:2880-6 pubmed
    ..Furthermore, the DUF59 family includes ORFs that are part of a conserved chromosomal group of proteins predicted to be involved in Fe-S cluster metabolism. ..
  55. Hansen G, Harrenga A, Wieland B, Schomburg D, Reinemer P. Crystal structure of full length topoisomerase I from Thermotoga maritima. J Mol Biol. 2006;358:1328-40 pubmed publisher
    ..A functional role of domain V in DNA binding and recognition is suggested and discussed in the light of the structure and previous biochemical findings. In addition, implications for bacterial topoisomerases I are provided...
  56. Offant J, Michoux F, Dermiaux A, Biton J, Bourne Y. Functional characterization of the glycosyltransferase domain of penicillin-binding protein 1a from Thermotoga maritima. Biochim Biophys Acta. 2006;1764:1036-42 pubmed
    ..Overall, our preliminary data document the biochemical properties of GT-PBP1a* and should guide further studies aimed at deciphering the structural determinants involved into membrane binding by this class of enzymes. ..
  57. Liebl W, Winterhalter C, Baumeister W, Armbrecht M, Valdez M. Xylanase attachment to the cell wall of the hyperthermophilic bacterium Thermotoga maritima. J Bacteriol. 2008;190:1350-8 pubmed publisher
    ..maritima via a hydrophobic peptide anchor, which is highly unusual for an outer membrane protein...
  58. Barbey C, Rouhier N, Haouz A, Navaza A, Jacquot J. Overproduction, purification, crystallization and preliminary X-ray analysis of the peroxiredoxin domain of a larger natural hybrid protein from Thermotoga maritima. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:29-31 pubmed
    ..The recombinant protein was crystallized and synchrotron data were collected to 2.9 A resolution. The crystals belonged to the tetragonal space group I422, with unit-cell parameters a = b = 176.67, c = 141.20 A. ..
  59. Notenboom V, Boraston A, Kilburn D, Rose D. Crystal structures of the family 9 carbohydrate-binding module from Thermotoga maritima xylanase 10A in native and ligand-bound forms. Biochemistry. 2001;40:6248-56 pubmed
    ..Cellobiose was found to bind in a distinct orientation from glucose, while still maintaining optimal stacking and electrostatic interactions with the reducing end sugar. ..
  60. Kn chel T, Pappenberger A, Jansonius J, Kirschner K. The crystal structure of indoleglycerol-phosphate synthase from Thermotoga maritima. Kinetic stabilization by salt bridges. J Biol Chem. 2002;277:8626-34 pubmed publisher
    ..This observation is consistent with a protein unfolding mechanism where the simultaneous breakdown of all salt bridges is the rate-determining step...
  61. Wu J, Howe D, Woodard R. Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase: the ancestral eubacterial DAHP synthase?. J Biol Chem. 2003;278:27525-31 pubmed publisher
    ..The activity of T. maritima DAHP synthase is inhibited by two of the three aromatic amino acids (l-Phe and l-Tyr) formed in the Shikimate pathway. This report is the first description of a thermophilic eubacterial DAHP synthase...
  62. Alberto F, Bignon C, Sulzenbacher G, Henrissat B, Czjzek M. The three-dimensional structure of invertase (beta-fructosidase) from Thermotoga maritima reveals a bimodular arrangement and an evolutionary relationship between retaining and inverting glycosidases. J Biol Chem. 2004;279:18903-10 pubmed publisher
    ..The variation in the position of the furanose ring at the site of cleavage explains the different mechanisms evident in families GH32 and GH68 (retaining) and GH43 (inverting) furanosidases...
  63. Schwarzenbacher R, McMullan D, Krishna S, Xu Q, Miller M, Canaves J, et al. Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 A resolution reveals a new fold. Proteins. 2006;65:243-8 pubmed publisher
  64. Morar M, Hoskins A, Stubbe J, Ealick S. Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation. Biochemistry. 2008;47:7816-30 pubmed publisher
    ..The flexibility of the PurS dimer is proposed to play a role in the activation of the complex and the formation of the ammonia channel. A potential path for the ammonia channel is identified...
  65. Allen W, Corey R, Oatley P, Sessions R, Baldwin S, Radford S, et al. Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation. elife. 2016;5: pubmed publisher
    ..The model represents a solution to the problem of transporting inherently variable substrates such as polypeptides, and may underlie mechanisms of other motors that translocate proteins and nucleic acids. ..
  66. Singh M, Manoj N. Structural role of a conserved active site cis proline in the Thermotoga maritima acetyl esterase from the carbohydrate esterase family 7. Proteins. 2017;85:694-708 pubmed publisher
    ..Proteins 2017; 85:694-708. © 2016 Wiley Periodicals, Inc. ..
  67. Davies C, White S, Ramakrishnan V. The crystal structure of ribosomal protein L14 reveals an important organizational component of the translational apparatus. Structure. 1996;4:55-66 pubmed
    ..The second site is smaller and may become occupied during the later compaction of the RNA. The surface hydrophobic patch is a likely site of protein-protein interaction, possibly with L19...
  68. Lloyd S, Whitby F, Blair D, Hill C. Structure of the C-terminal domain of FliG, a component of the rotor in the bacterial flagellar motor. Nature. 1999;400:472-5 pubmed publisher
    ..On the basis of the disposition of these residues, we present a hypothesis for the orientation of FliG-C domains in the flagellar motor, and propose a structural model for the part of the rotor that interacts with the stator...
  69. Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, et al. Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643. J Biol Chem. 2003;278:8804-8 pubmed publisher
    ..Therefore, our studies demonstrate that two different enzymes, an oxidase and a dehydrogenase, may have evolved to catalyze the first step of NAD biosynthesis in prokaryotes. TM1643 establishes a new class of amino acid dehydrogenases...
  70. Lee J, Ahn H, Ha K, Suh S. Crystal structure of the TM1442 protein from Thermotoga maritima, a homolog of the Bacillus subtilis general stress response anti-anti-sigma factor RsbV. Proteins. 2004;56:176-9 pubmed
  71. Guo R, Kuo C, Ko T, Chou C, Liang P, Wang A. A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products. Biochemistry. 2004;43:7678-86 pubmed publisher
    ..Further modifications of the enzyme reaction conditions, including new IPP derivatives, may allow the preparation of high-molecular weight polyprenyl products resembling the rubber molecule...
  72. Shin D, Lou Y, Jancarik J, Yokota H, Kim R, Kim S. Crystal structure of YjeQ from Thermotoga maritima contains a circularly permuted GTPase domain. Proc Natl Acad Sci U S A. 2004;101:13198-203 pubmed publisher
    ..The overall structural features of TmYjeQ make it a good candidate for an RNA-binding protein, which is consistent with the biochemical data of the YjeQ subfamily in binding to the ribosome...
  73. Columbus L, Peti W, Etezady Esfarjani T, Herrmann T, Wuthrich K. NMR structure determination of the conserved hypothetical protein TM1816 from Thermotoga maritima. Proteins. 2005;60:552-7 pubmed
  74. Padmanabhan B, Deshmukh P, Yokoyama S, Bessho Y. Crystal structure of the MazG-related nucleoside triphosphate pyrophosphohydrolase from Thermotoga maritima MSB8. J Struct Funct Genomics. 2015;16:81-9 pubmed publisher
    ..The primary structure of TM0360 from Thermotoga maritima MSB8 suggested that TM0360 is a MazG-related nucleoside triphosphate pyrophosphohydrolase...
  75. Beismann Driemeyer S, Sterner R. Imidazole glycerol phosphate synthase from Thermotoga maritima. Quaternary structure, steady-state kinetics, and reaction mechanism of the bienzyme complex. J Biol Chem. 2001;276:20387-96 pubmed publisher
    ..The carboxylate groups of these residues could provide general acid/base catalysis in the proposed catalytic mechanism of the synthase reaction...
  76. Fern ndez Murga M, Gil Ortiz F, Ll cer J, Rubio V. Arginine biosynthesis in Thermotoga maritima: characterization of the arginine-sensitive N-acetyl-L-glutamate kinase. J Bacteriol. 2004;186:6142-9 pubmed publisher
    ..Potential thermostability determinants of T. maritima NAGK are also discussed...
  77. Johnson H, Hampton E, Lesley S. The Thermotoga maritima Trk potassium transporter--from frameshift to function. J Bacteriol. 2009;191:2276-84 pubmed publisher
    ..This class, as exemplified by Mycobacterium tuberculosis, did not complement E. coli potassium transport with the native E. coli TrkH; thus, it may require a novel TrkH-like protein for activity or provide an alternate function in vivo...
  78. Rivalta I, Lisi G, Snoeberger N, Manley G, Loria J, Batista V. Allosteric Communication Disrupted by a Small Molecule Binding to the Imidazole Glycerol Phosphate Synthase Protein-Protein Interface. Biochemistry. 2016;55:6484-6494 pubmed
  79. Liao D, Dennis P. The organization and expression of essential transcription translation component genes in the extremely thermophilic eubacterium Thermotoga maritima. J Biol Chem. 1992;267:22787-97 pubmed
    ..The T. maritima NusG protein exhibits 43% amino acid sequence identity when aligned to the E. coli protein; the alignment is interrupted by a large 171-amino acid-long insertion into the T. maritima protein after codon 45...
  80. Sterner R, Dahm A, Darimont B, Ivens A, Liebl W, Kirschner K. (Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima. EMBO J. 1995;14:4395-402 pubmed
    ..Another notable feature is the predicted lack of the N-terminal helix alpha 0 in the alpha-subunit of tryptophan synthase...
  81. Ostendorp R, Auerbach G, Jaenicke R. Extremely thermostable L(+)-lactate dehydrogenase from Thermotoga maritima: cloning, characterization, and crystallization of the recombinant enzyme in its tetrameric and octameric state. Protein Sci. 1996;5:862-73 pubmed publisher
    ..Both the high optimal temperature and the pH optimum of the catalytic activity correspond to the growth conditions of T. maritima in its natural habitat...
  82. Liebl W, Ruile P, Bronnenmeier K, Riedel K, Lottspeich F, Greif I. Analysis of a Thermotoga maritima DNA fragment encoding two similar thermostable cellulases, CelA and CelB, and characterization of the recombinant enzymes. Microbiology. 1996;142 ( Pt 9):2533-42 pubmed publisher
    ..activity were isolated from two different gene libraries of the hyperthermophilic bacterium Thermotoga maritima MSB8 (DSM 3109), and the nucleotide sequence of a 1,4-beta-glucanase gene designated celA was determined...
  83. Zverlov V, Volkov I, Velikodvorskaya T, Schwarz W. Highly thermostable endo-1,3-beta-glucanase (laminarinase) LamA from Thermotoga neapolitana: nucleotide sequence of the gene and characterization of the recombinant gene product. Microbiology. 1997;143 ( Pt 5):1701-8 pubmed publisher
    ..Thus, LamA is the most thermostable 1,3-beta-glucanase described to date...
  84. Liebl W, Brem D, Gotschlich A. Analysis of the gene for beta-fructosidase (invertase, inulinase) of the hyperthermophilic bacterium Thermotoga maritima, and characterisation of the enzyme expressed in Escherichia coli. Appl Microbiol Biotechnol. 1998;50:55-64 pubmed
    ..The bfrA gene of the ancestral bacterium Thermotoga maritima MSB8 codes for a 432-residue, polypeptide of about 50 kDa, with significant sequence similarity to other beta-..
  85. Nakagawa A, Nakashima T, Taniguchi M, Hosaka H, Kimura M, Tanaka I. The three-dimensional structure of the RNA-binding domain of ribosomal protein L2; a protein at the peptidyl transferase center of the ribosome. EMBO J. 1999;18:1459-67 pubmed publisher
    ..The molecular architecture suggests how this important protein has evolved from the ancient nucleic acid-binding proteins to create a 23S rRNA-binding domain in the very remote past...
  86. Chen L, Roberts M. Characterization of a tetrameric inositol monophosphatase from the hyperthermophilic bacterium Thermotoga maritima. Appl Environ Microbiol. 1999;65:4559-67 pubmed
    ..Possible reasons for the observed kinetic differences are discussed based on an active site sequence alignment of the human and T. maritima I-1-Pases...
  87. Worbs M, Huber R, Wahl M. Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon. EMBO J. 2000;19:807-18 pubmed publisher
    ..The structure also suggests a C-terminal protein-binding interface, through which L4 could be interacting with protein components of the transcriptional and/or translational machineries...
  88. Dams T, Auerbach G, Bader G, Jacob U, Ploom T, Huber R, et al. The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability. J Mol Biol. 2000;297:659-72 pubmed publisher
    ..The active-site loop, which is known to play an important role in catalysis in mesophilic dihydrofolate reductase molecules, is rearranged, participating in the association of the subunits; it no longer participates in catalysis...
  89. Cordell S, Anderson R, L we J. Crystal structure of the bacterial cell division inhibitor MinC. EMBO J. 2001;20:2454-61 pubmed publisher
    ..MinC does not act like SulA, which affects the GTPase activity of FtsZ, and the model can explain how MinC would select for the FtsZ polymer rather than the monomer...
  90. Guo R, Kuo C, Chou C, Ko T, Shr H, Liang P, et al. Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination. J Biol Chem. 2004;279:4903-12 pubmed publisher
    ..The new structure of the trans-type OPPs, together with the recently determined cis-type UPPs, significantly extends our understanding on the biosynthesis of long chain polyprenyl molecules...
  91. Shin D, Nguyen H, Jancarik J, Yokota H, Kim R, Kim S. Crystal structure of NusA from Thermotoga maritima and functional implication of the N-terminal domain. Biochemistry. 2003;42:13429-37 pubmed publisher
    ..Structural comparison between TmNusA and Mycobacterium tuberculosis NusA reveals a possible hinge motion between NTD and RBD. In addition, a functional implication of the NTD in its interaction with RNA polymerase is discussed...
  92. Agrawal R, Sharma M, Kiel M, Hirokawa G, Booth T, Spahn C, et al. Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: functional implications. Proc Natl Acad Sci U S A. 2004;101:8900-5 pubmed publisher