Genomes and Genes
Publications122 found, 100 shown here
- UK malaria treatment guidelinesDavid G Lalloo
Clinical Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
J Infect 54:111-21. 2007..Uncomplicated P. falciparum malaria can be treated orally with quinine, atovaquone plus proguanil (Malarone) or co-artemether (Riamet); quinine is highly effective but poorly tolerated ..
- Quality evaluation of chloroquine, quinine, sulfadoxine-pyrimethamine and proguanil formulations sold on the market in East Congo DRM A Atemnkeng
Pharmaceutical Technology and Physical Pharmacy Department, Pharmaceutical Institute, Vrije Universiteit Brussel, Brussels, Belgium
J Clin Pharm Ther 32:123-32. 2007..Eur.). The second aim was to check the extent to which simple methods of analysis could be used to evaluate drug quality...
- The effect of mimicking febrile temperature and drug stress on malarial developmentRatchaneewan Aunpad
Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand
Ann Clin Microbiol Antimicrob 8:19. 2009..These trigger malarial evolutionarily adaptive responses. The effect of febrile temperature on malarial growth, development and drug susceptibility by mimicking patient in treatment failure before and after drug uptake was examined...
- [In vitro susceptibility of P. falciparum isolates from Abidjan (Côte d'Ivoire) to quinine, artesunate and chloroquine]André Offianan Touré
Institut Pasteur de Côte d Ivoire, Unité de Paludologie, 01 BP 490 Abidjan 01, Ivory Coast
Sante 18:43-7. 2008..These make it possible to detect changes in susceptibility and are expected to prevent the emergence of resistance against the most recently introduced combined therapy...
- Anti-filarial effects of nine quinoline-containing drugs on adult filariae in vitroE A Vandewaa
Department of Microbiology and Public Health, Michigan State University, East Lansing 48824
J Parasitol 75:367-72. 1989..chloroquine, (bis)desethylchloroquine, SN6911, SN12108, amodiaquine, CN-2999-2K, primaquine, quinacrine, and quinine were examined in vitro against adult female Brugia pahangi...
- Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6S W Ellis
Section of Molecular Pharmacology and Pharmacogenetics, L Floor, Royal Hallamshire Hospital, Glossop Road, University of Sheffield, Sheffield S10 2JF, U K
Biochem J 345:565-71. 2000..in substrate enantioselectivity and the differential inhibition of enzyme activity by the diastereoisomers quinine and quinidine...
- Differential effects of salicylate, quinine, and furosemide on Guinea pig inner and outer hair cell function revealed by the input-output relation of the auditory brainstem responseMartin Pienkowski
Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm
J Am Acad Audiol 22:104-12. 2011..There have been a number of attempts to differentiate between these etiologies of hearing loss, using various psychoacoustic and physiologic paradigms...
- In vitro study assessing the response of plasmodium falciparum malaria to chloroquine, sulfadoxine/pyrimethamine, quinine and mefloquine in Wad Medani District, SudanBakri Y Nour
Faculty of Medicine, Blue Nile Research and Training Institute, University of Gezira, PO Box 101, Wad Medani, Sudan
Saudi Med J 27:808-12. 2006To assess the in vitro response of Plasmodium falciparum malaria to chloroquine (CQ), sulfadoxine/pyrimethamine (SDX/PYR), Quinine (QU) and Mefloquine (MQ) and monitoring their resistance.
- Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40S J Cook
School of Biological Sciences, University of Manchester
Br J Pharmacol 114:143-51. 1995..4. Quinine (30 microM) caused little or no change in tissue tone and did not modify the relaxant action of isoprenaline...
- Susceptibility of Malaysian Plasmodium falciparum isolates to antimalarial drugs after cryopreservation and 12 months of continuous in vitro cultureH H Ang
School of Pharmaceutical Sciences, University of Science Malaysia, Penang
Chemotherapy 43:311-5. 1997..0 and 690.1 for chloroquine; 3.4, 3.4, 9.2, 4.0 and 5.8 for mefloquine; 21.9, 10.5, 40.7, 40.1 and 48.7 for quinine; 136.7, 58.8, 116.4, 29.4 and 95.4 for cycloguanil, and 48.3, 57.5, 47.4, 61.5 and 37.8 for pyrimethamine...
- Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. II. Electrophysiological and fluorimetric studiesI Rustenbeck
Institute of Clinical Biochemistry, Hannover Medical School, D 30623, Hannover, Germany
Biochem Pharmacol 62:1695-703. 2001..secretagogues that block ATP-dependent K(+) channels (K(ATP) channels), such as sulfonylureas, imidazolines, and quinine, induced a desensitization of insulin secretion (Rustenbeck et al., pages 1685-1694, this issue)...
- A nationwide survey of the quality of antimalarials in retail outlets in TanzaniaHarparkash Kaur
Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, UK
PLoS ONE 3:e3403. 2008..This study aimed to assess the quality of antimalarials available from retail outlets across mainland Tanzania...
- Compliance with artesunate and quinine + tetracycline treatment of uncomplicated falciparum malaria in ThailandW Fungladda
Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Bull World Health Organ 76:59-66. 1998A randomized, controlled, malaria-clinic-based field trial was conducted to compare compliance with a 7-day quinine + tetracycline regimen and a 5-day 700-mg artesunate regimen for the treatment of uncomplicated falciparum malaria in a ..
- Drug-induced immune thrombocytopeniaPatricia M L A van den Bemt
Hospital Pharmacy Midden Brabant, TweeSteden Hospital and St Elisabeth Hospital, Tilburg, The Netherlands
Drug Saf 27:1243-52. 2004..The drug classes that are most often associated with drug-induced immune thrombocytopenia are cinchona alkaloid derivatives (quinine, quinidine), sulfonamides, NSAIDs, anticonvulsants, disease modifying antirheumatic ..
- The historical aspects of sunscreensF Urbach
Charles River Laboratories Inc, Argus Division, 905 Sheehy Drive, Horsham, PA 19044, USA
J Photochem Photobiol B 64:99-104. 2001..Hygiea, Festband #3, Samson and Wallin, Stockholm) used acidified quinine sulfate to absorb UVB, apparently because, since quinine fluoresces when irradiated with UVR, he rightly assumed ..
- Atovaquone and azithromycin for the treatment of babesiosisP J Krause
Division of Infectious Diseases, Connecticut Children s Medical Center and the University of Connecticut School of Medicine, Hartford 06106, USA
N Engl J Med 343:1454-8. 2000..A course of clindamycin and quinine is the standard treatment, but this regimen frequently causes adverse reactions and occasionally fails...
- Taste masking analysis in pharmaceutical formulation development using an electronic tongueJack Y Zheng
Pharmaceutical Sciences R and D, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46225, USA
Int J Pharm 310:118-24. 2006..Taste-masking efficiency was evaluated using quinine as a bitter model compound and a sweetener, acesulfame K, as a bitterness inhibitor. In a 0...
- The effects of rubidium, caesium and quinine on 5-HT-mediated behaviour in rat and mouse--3. QuinineH Wang
MRC Unit, Radcliffe Infirmary, Oxford, U K
Neuropharmacology 31:425-31. 1992It has been shown that caesium, which shares properties with quinine as a K(+)-channel blocker, enhanced 5-HT-mediated behaviour in both rats and mice...
- Liquid chromatographic analysis of cinchona alkaloids in beveragesMasao Horie
Tokyo Metropolitan Institute of Public Health, Department of Food Safety, 3 24 1 Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
J AOAC Int 89:1042-7. 2006A method for the determination of Cinchona extract (whose main components are the alkaloids cinchonine, cinchonidine, quinidine, and quinine) in beverages by liquid chromatography was developed...
- Quinine-induced disseminated intravascular coagulation: case report and review of the literatureMark T Knower
Section on Pulmonary and Critical Care, Ochsner Clinic North Shore, 804 Heavens Drive, Suite 105, Mandeville, LA 70471, USA
Intensive Care Med 29:1007-11. 2003To describe the clinical course of quinine-induced disseminated intravascular coagulation (DIC) and review all previous cases reported in the medical literature.
- Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modificationRussell S J Keast
Food Science, RMIT University, Cnr Russell and Victoria St, Melbourne, Victoria 3001, Australia
Pharm Res 22:1970-7. 2005Zinc sulfate is known to inhibit the bitterness of the antimalarial agent quinine [R. S. J. Keast. The effect of zinc on human taste perception. J. Food Sci. 68:1871-1877 (2003)]...
- The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT3 receptorsA J Thompson
Department of Biochemistry, University of Cambridge, Cambridge, UK
Br J Pharmacol 151:666-77. 2007The antimalarial compounds quinine, chloroquine and mefloquine affect the electrophysiological properties of Cys-loop receptors and have structural similarities to 5-HT(3) receptor antagonists. They may therefore act at 5-HT(3) receptors.
- A comparative study of artesunate and artemether in combination with mefloquine on multidrug resistant falciparum malaria in eastern ThailandK Thimasarn
Department of Communicable Disease Control, Ministry of Public Health, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 28:465-71. 1997..in Thailand is highly resistant to chloroquine, sulfadoxine-pyrimethamine and there is increasing resistance to quinine and mefloquine...
- Efficacies of chloroquine, sulfadoxine-pyrimethamine and quinine in the treatment of uncomplicated, Plasmodium falciparum malaria in eastern SudanI Adam
New Halfa Teaching Hospital, P O Box 61, New Halfa, Sudan
Ann Trop Med Parasitol 98:661-6. 2004..completed the 28 days of follow-up were treated with chloroquine (N = 26), sulfadoxine-pyrimethamine (N = 38) or quinine (N = 32). No treatment failures were observed among the patients given sulfadoxine-pyrimethamine. Only 23...
- In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from KenyaJohn Okombo
Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Program, P O Box 230, 80108 Kilifi, Kenya
Antimicrob Agents Chemother 54:3302-7. 2010Resistance to the amino alcohol quinine has been associated with polymorphisms in pfnhe, a sodium hydrogen exchanger. We investigated the role of this gene in quinine resistance in vitro in isolates from Kenya...
- Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. I. Secretory and morphological studiesI Rustenbeck
Institute of Clinical Biochemistry, Hannover Medical School, D 30623, Hannover, Germany
Biochem Pharmacol 62:1685-94. 2001..of the well-characterized sulfonylurea, tolbutamide (500 microM), and those of the ion channel-blocking alkaloid, quinine (100 microM)...
- Beta-cell toxicity of ATP-sensitive K+ channel-blocking insulin secretagoguesIngo Rustenbeck
Institute of Pharmacology and Toxicology, Technical University of Braunschweig, D 38106 Braunschweig, Germany
Biochem Pharmacol 67:1733-41. 2004..phentolamine, alinidine and idazoxan (100microM each), the sulfonylurea tolbutamide (500microM), or the alkaloid quinine (100microM) resulted in morphological damage of 4-18% of beta-cells compared to less than 2% in controls...
- The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymesMagnus Christensen
Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
Clin Pharmacol Ther 73:517-28. 2003..were (1) to determine whether the drugs caffeine, losartan, omeprazole, debrisoquin (INN, debrisoquine), and quinine can be given simultaneously in low doses as a cocktail for the phenotyping of cytochrome P450 (CYP) 1A2, 2C9, ..
- Drug-resistant malaria in Bangui, Central African Republic: an in vitro assessmentDidier Menard
Pasteur Institute of Bangui, Bangui, Central African Republic
Am J Trop Med Hyg 73:239-43. 2005..We tested antimalarials that are currently in use in this country (chloroquine, amodiaquine, quinine, and pyrimethamine), antimalarials that will become available in this region in the future (artemisinin and ..
- Barium- or quinine-induced depolarization activates K+, Na+ and cationic conductances in frog proximal tubular cellsF Discala
INSERM U 323, Faculte de Medecine Necker Enfants Malades, Paris, France
J Physiol 448:525-37. 1992..tK went up to 0.83. 4. The high tK preparation was challenged with barium (3 mM) or quinine (Quin, 1 mM)...
- Quinoline antimalarials decrease the rate of beta-hematin formationTimothy J Egan
Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa
J Inorg Biochem 99:1532-9. 2005..or malaria pigment) formation by the quinoline antimalarial drugs chloroquine, amodiaquine, quinidine and quinine has been investigated as a function of incubation time...
- Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomersAnnika Allqvist
Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Pharmacology at Karolinska University Hospital, Huddinge, Stockholm, Sweden
Eur J Clin Pharmacol 63:173-9. 2007..Most of them, however, involved the KTZ racemate. KTZ racemate and the separate enantiomers, 2R,4R; 2R,4S; 2S,4S, and 2S,4R, were evaluated for their selectivity in inhibiting alprazolam and quinine metabolism.
- Quantitative trait loci associated with short-term intake of sucrose, saccharin and quinine solutions in laboratory miceD A Blizard
Center for Developmental and Health Genetics and Intercollege Graduate Program in Genetics, The Pennsylvania State University, University Park 16802, USA
Chem Senses 24:373-85. 1999..to map two genetic loci which, collectively, have a large effect on intake of sucrose, saccharin and quinine solutions in mice...
- Exposure to sucrose-quinine solutions does not increase ethanol consumptionC J Slawecki
Department of Physiology and Pharmacology, The Wake Forest University School of Medicine, Winston Salem, NC, USA
Alcohol 16:329-35. 1998..The consumption of 0-20% ethanol was then determined before and after exposure to a sucrose-quinine solution...
- Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: a randomized, phase 2 clinical trial in ThailandHarald Noedl
1Department of Immunology and Medicine, USAMC AFRIMS, Bangkok, Thailand
Clin Infect Dis 43:1264-71. 2006..Azithromycin is a macrolide antibiotic that is particularly attractive as an antimalarial because of its safety in children and the extensive experience with its use during pregnancy...
- Myosin II-dependent cylindrical protrusions induced by quinine in Dictyostelium: antagonizing effects of actin polymerization at the leading edgeK Yoshida
Department of Botany, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
J Cell Sci 114:2155-65. 2001We found that amoeboid cells of Dictyostelium are induced by a millimolar concentration of quinine to form a rapidly elongating, cylindrical protrusion, which often led to sustained locomotion of the cells...
- Stimulation of bitterness by capsaicin and menthol: differences between lingual areas innervated by the glossopharyngeal and chorda tympani nervesBarry G Green
The John B Pierce Laboratory, Yale School of Medicine, 290 Congress Avenue, New Haven, CT 06519, USA
Chem Senses 28:45-55. 2003..Sucrose, citric acid, sodium chloride and quinine hydrochloride were applied to the same areas to assess tastes responsiveness...
- Antimalarial drugs inhibit human 5-HT(3) and GABA(A) but not GABA(C) receptorsA J Thompson
Department of Biochemistry, University of Cambridge, Cambridge, UK
Br J Pharmacol 153:1686-96. 2008..Here, we extend these studies to include human 5-HT(3A), 5-HT(3AB), GABA(A) alpha1beta2, GABA(A) alpha1beta2gamma2 and GABA(C) rho1 receptors...
- Acceptability and efficacy of intra-rectal quinine alkaloids as a pre-transfer treatment of non-per os malaria in peripheral health care facilities in Mopti, MaliMahamadou A Thera
Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases DEAP Faculty of Medicine, Pharmacy and Odonto Stomatologie, University of Bamako, Bamako, Mali
Malar J 6:68. 2007The acceptability and efficacy of a new kit with a new formulation of quinine alkaloids designed for the intra-rectal administration in the treatment of non-per os malaria was assessed in the peripheral health care system of Mopti, Mali.
- Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out miceKrisztina M Kovacs
Laboratory of Neurobehavioral GeneticsNathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Alcohol Clin Exp Res 29:730-8. 2005..Here we examined the effects of targeted disruption of kappa-opioid receptor (KOR) on oral alcohol self-administration and other behaviors...
- Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trialRobert Gurkov
Department of Otorhinolaryngology Head and Neck Surgery, Ludwig Maximilians University, Munich, Germany
Malar J 7:179. 2008..The aim of the study was to compare ototoxicity, tolerability, and efficacy of ACT with that of quinine and atovaquone/proguanil in the treatment of uncomplicated falciparum malaria.
- [Intrarectal administration of quinine: an early treatment for severe malaria in children?]H Barennes
Centre Muraz, BP 153, Bobo Dioulasso, Burkina Faso
Sante 11:145-53. 2001..We recently showed the kinetic profile, the optimal regimen and the clinical efficacy of intrarectal quinine (QIR) using Quinimax (Sanofi, Gentilly France) 20 mg/kg in solution with 2 ml of water...
- [Limits of the efficacy of chloroquine and sulfadoxine-pyrimethamine in Northern Abidjan (Cote d'Ivoire): Combined in vivo and in vitro studies]Joseph Djaman
Unite de Parasitologie, Laboratoire de microbiologie de l Institut national de santé publique Abidjan, BP V 47 Abidjan Laboratoire de pharmacodynamie biochimique, UFR Biosciences, Universite de Cocody, Abidjan, Cote d Ivoire
Sante 14:205-9. 2004..falciparum isolates were cultured in the presence of variable concentrations of chloroquine, pyrimethamine and quinine during in vitro chemosensitivity tests...
- Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domainJose A Sanchez-Chapula
Unidad de Investigación Carlos Méndez del Centro Universitario de Investigaciones Biomédicas de la Universidad de Colima, Colima, Mexico
Mol Pharmacol 63:1051-8. 2003..The IC(50) values determined with voltage-clamp pulses to 0 mV were 4.6 microM and 57 microM for quinidine and quinine, respectively...
- Crystal structure of (-)-mefloquine hydrochloride reveals consistency of configuration with biological activityJean M Karle
Department of Medicinal Chemistry, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 7500, USA
Antimicrob Agents Chemother 46:1529-34. 2002..the hydrochloride salt, thus allowing comparison of the configuration of mefloquine's optical isomers to those of quinine and quinidine...
- Skin permeation enhancement potential of Aloe Vera and a proposed mechanism of action based upon size exclusion and pull effectLouise Cole
Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, United Kingdom
Int J Pharm 333:10-6. 2007..Saturated solutions of caffeine, colchicine, mefenamic acid, oxybutynin, and quinine were prepared at 32 degrees C in Aloe Vera juice and water (control) and used to dose porcine ear skin mounted in ..
- Quinine-induced arrhythmia in a patient with severe malariaCarta A Gunawan
Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine Mulawarman University A Wahab Sjahranie General Hospital, Samarinda
Acta Med Indones 39:27-32. 2007..malaria patient with jaundice who presented with arrhythmia (premature ventricular contraction) while getting quinine infusion was reported. A man, 25 years old, was admitted to hospital with high fever, chill, vomiting, jaundice...
- Taste-masked quinine sulphate pellets: bio-availability in adults and steady-state plasma concentrations in children with uncomplicated Plasmodium falciparum malariaP C Kayumba
Department of Pharmacy, National University of Rwanda, Butare, Rwanda
Ann Trop Paediatr 28:103-9. 2008b>Quinine sulphate (QS), like most other antimalarials, is in tablet form designed for adults. In children, treatment is based on breaking the tablets to adapt the dose to the child's bodyweight...
- Ethanol-associated olfactory stimuli reinstate ethanol-seeking behavior after extinction and modify extracellular dopamine levels in the nucleus accumbensS N Katner
The Scripps Research Institute, Department of Neuropharmacology, La Jolla, California 92037, USA
Alcohol Clin Exp Res 23:1751-60. 1999..The present study employed an operant response-reinstatement model to examine the effects of ethanol-associated environmental stimuli on alcohol-seeking behavior and extracellular dopamine (DA) levels in the nucleus accumbens (NAcc)...
- Comparison of oral artesunate and quinine plus tetracycline in acute uncomplicated falciparum malariaJ Karbwang
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Bull World Health Organ 72:233-8. 1994..We have carried out a comparative clinical trial of the standard regimen of quinine + tetracycline versus oral artesunate at a 700-mg total dose given over 5 days to patients with acute ..
- Mefloquine versus quinine plus sulphalene-pyrimethamine (metakelfin) for treatment of uncomplicated imported falciparum malaria acquired in AfricaAlberto Matteelli
Institute of Infectious and Tropical Diseases, University of Brescia, Brescia 25125, Italy
Antimicrob Agents Chemother 49:663-7. 2005We conducted a multicenter, randomized, open-label trial to compare mefloquine with a 3-day quinine plus sulphalene-pyrimethamine (SP) regimen for the treatment of imported uncomplicated malaria acquired in Africa...
- Role of parabrachial nucleus in submandibular salivary secretion induced by bitter taste stimulation in ratsR Matsuo
Department of Oral Physiology, Okayama University Dental School, Japan
Auton Neurosci 88:61-73. 2001When rats lick a bitter taste solution such as quinine-hydrochloride, they secrete profuse amounts of saliva. The salivation has a higher flow rate than that induced by other qualities of taste stimulation: sweet, salty, and sour...
- Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugsCoy D Fitch
Department of Internal Medicine, School of Medicine, Saint Louis University Health Sciences Center, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Life Sci 74:1957-72. 2004..Treatment with quinoline-4-methanol drugs, such as quinine and mefloquine, also causes morphologic changes, but does not cause hemoglobin accumulation...
- Treatment of uncomplicated malaria in children in Guinea-Bissau with chloroquine, quinine, and sulfadoxine-pyrimethaminePoul Erik Kofoed
Department of Paediatrics, Kolding Hospital, Denmark
Trans R Soc Trop Med Hyg 96:304-9. 2002..children with Plasmodium falciparum mono-infection were allocated at random to one of 4 treatments: 15 mg/kg quinine twice a day for 3 d (group 1); 10 mg/kg quinine twice a day for 3 d followed by a total dose of 25 mg chloroquine ..
- Quinine disposition in globally malnourished children with cerebral malariaE Pussard
Institut National de la Sante et de la Recherche Medicale, Unité 13, CHU Bichat, Paris, France
Clin Pharmacol Ther 65:500-10. 1999Both malnutrition and malaria affect drug disposition and are frequent among children in the tropics. We assessed their respective influence on quinine distribution.
- Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunateWanna Chaijaroenkul
Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Rangsit, Patumthani 12121, Thailand
Acta Trop 113:190-4. 2010..falciparum isolates to chloroquine (CQ), mefloquine (MQ), quinine (QN) and the artemisinin derivative - artesunate (AS). A total of 26 P...
- Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, IndonesiaA Ratcliff
International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia
Trans R Soc Trop Med Hyg 101:351-9. 2007..vivax infections. Patients with P. falciparum failing therapy were re-treated with unsupervised quinine+/-doxycycline therapy and those with P. vivax with either unsupervised quinine+/-doxycycline or amodiaquine...
- Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trialJane Achan
Makerere University School of Health Sciences, PO Box 7475, Kampala, Uganda
BMJ 339:b2763. 2009To compare the effectiveness of oral quinine with that of artemether-lumefantrine in treating uncomplicated malaria in children.
- Pharmacokinetics of quinine and its metabolites in pregnant Sudanese women with uncomplicated Plasmodium falciparum malariaI I Abdelrahim
Faculty of Medicine, University of Khartoum, Khartoum, Sudan
J Clin Pharm Ther 32:15-9. 2007The study was conducted in New Halfa teaching hospital, eastern Sudan to investigate the pharmacokinetics of quinine in pregnant Sudanese women.
- Separation of Cinchona alkaloids on a novel strong cation-exchange-type chiral stationary phase-comparison with commercially available strong cation exchanger and reversed-phase packing materialsChristian V Hoffmann
Department of Analytical Chemistry and Food Chemistry, Christian Doppler Laboratory for Molecular Recognition Materials, University of Vienna, Wahringer Strasse 38, A 1090, Vienna, Austria
Anal Bioanal Chem 393:1257-65. 2009..chiral strong cation exchanger (cSCX) type stationary phase was investigated for the LC separation of a series of Cinchona alkaloids and synthetic derivatives thereof to test its usefulness as alternative methodology for the separation ..
- Quinine, an old anti-malarial drug in a modern world: role in the treatment of malariaJane Achan
Department of Pediatrics and Child Health, Makerere University College of Health Sciences, P O Box 7475, Kampala, Uganda
Malar J 10:144. 2011b>Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented...
- Variable inhibitory effect of different brands of commercial herbal supplements on human cytochrome P-450 CYP3A4Sompon Wanwimolruk
School of Pharmacy, Loma Linda University, Loma Linda, CA 92350, USA
Drug Metabol Drug Interact 24:17-35. 2009..Aliquots of the extract were tested for their ability to inhibit the metabolism of the human CYP3A4 probe quinine, using an in vitro liver microsomal technique...
- Quinine sulphate pellets for flexible pediatric drug dosing: formulation development and evaluation of taste-masking efficiency using the electronic tongueP C Kayumba
Department of Pharmacy, National University of Rwanda, Butare, Rwanda
Eur J Pharm Biopharm 66:460-5. 2007The purpose of this study was to develop a taste-masked quinine sulphate dosage form as a flexible pediatric formulation tool...
- [A history of malaria in modern Korea 1876-1945]Insok Yeo
Department of Medical History, Yonsei University, Seoul, Korea
Uisahak 20:53-82. 2011..Very effective anti-malarial drug quinine was imported and it made great contribution in treating malaria...
- Bifunctional catalysis by natural cinchona alkaloids: a mechanism explainedClotilde S Cucinotta
Computational Science, Department of Chemistry and Applied Biosciences, ETH Zurich c o USI Campus, Via Giuseppe Buffi 13, 6900 Lugano, Switzerland
Chemistry 15:7913-21. 2009..b>Cinchona alkaloids such as quinine and quinidine, simple organic molecules generously provided by Nature, were the first ..
- Sweet and bitter taste of ethanol in C57BL/6J and DBA2/J mouse strainsDavid A Blizard
Center for Developmental and Health Genetics, The Pennsylvania State University, 201, Research Building D, University Park, PA 16802, USA
Behav Genet 37:146-59. 2007..conditioned taste aversion (CTA) to explore the sweet and bitter taste of ethanol and ability to detect sucrose, quinine and ethanol in C57BL/6J (B6) and DBA/2J (D2) mouse strains that are frequently used in alcohol research...
- Taste reactivity and its modulation by morphine and methamphetamine in C57BL/6 and DBA/2 miceBarbara Cagniard
Molecular Neuropathology Group, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
Physiol Behav 96:412-20. 2009..In particular, compared to D2 mice, B6 mice avidly drink ethanol and sucrose solutions, but avoid quinine solutions...
- Chronic alcohol administration in the rat pup: effects upon later consumption of alcohol and other palatable solutionsM F Lopez
Instituto de Investigacion Medica, Mercedesy Martín Ferreyra, CONICET, Cordoba, Argentina
Addict Biol 4:169-79. 1999..consumption of an ethanol solution as well as upon intake of various non-ethanol solutions (water, sucrose, quinine or sucrose mixed with quinine)...
- Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptakeSandra C dos Santos
Institute for Biotechnology and Bioengineering IBB, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal
Antimicrob Agents Chemother 53:5213-23. 2009b>Quinine has been employed in the treatment of malaria for centuries and is still used against severe Plasmodium falciparum malaria. However, its interactions with the parasite remain poorly understood and subject to debate...
- Taste coding after selective inhibition by chlorhexidineMiao Fen Wang
John B Pierce Laboratory, Yale University School of Medicine, New Haven, CT 06519, USA
Chem Senses 34:653-66. 2009..a bis-biguanide antiseptic, reversibly inhibits salty taste and tastes of a subset of bitter stimuli, including quinine hydrochloride. Identifications of salty (NaCl, "salt"), bitter (quinine...
- Diminished Plasmodium falciparum sensitivity to quinine exposure in vitro and in a sequential multi-drug regimen: A preliminary investigation in Guyana, South AmericaWallis Best Plummer
Department of Pharmacy, Faculty of Health Sciences, University of Guyana, Georgetown, Guyana
Int J Infect Dis 12:e27-31. 2008..to investigate the response of uncomplicated falciparum infections to semi-supervised drug administration with quinine and two adjunctive schizontocidal drugs in infected patients in Guyana...
- Application of multivariate methods to the simultaneous Fourier Transform Infrared (FT-IR) spectrometric determination of stereo-isomers; quinine and quinidineAbdel Aziz Mohamed Wahbi
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt
Chem Pharm Bull (Tokyo) 56:787-91. 2008The two stereo-isomers; quinine and quinidine have been determined in their mixtures in the IR region using chemometric multivariate methods, principal component regression (PCR) and partial least squares (PLS)...
- The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complexJohn N Alumasa
Department of Chemistry, Georgetown University, Washington, DC 20057, USA
J Inorg Biochem 105:467-75. 2011..Under biological conditions, chloroquine (CQ) appears to prefer to bind to ?-oxo dimeric heme, while quinine (QN) preferentially binds monomer...
- Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from AfricaValérie Andriantsoanirina
Institut Pasteur de Madagascar, Unité de Recherche sur le Paludisme, Antananarivo, Madagascar, France
Am J Trop Med Hyg 82:782-7. 2010..of polymorphisms in Plasmodium falciparum nhe-1 (Pfnhe-1, gene PF13_0019) with in vitro susceptibility to quinine, which was previously reported in a limited number of reference strains or culture-adapted isolates...
- Artemisinin derivatives versus quinine in treating severe malaria in children: a systematic reviewGeorge PrayGod
National Institute for Medical Research, Mwanza, Tanzania
Malar J 7:210. 2008The efficacy of intravenous quinine, which is the mainstay for treating severe malaria in children, is decreasing in South East Asia and Africa. Artemisinin derivatives are a potential alternative to quinine...
- Ethanol, saccharin, and quinine: early ontogeny of taste responsiveness and intakeAndrey P Kozlov
Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York 13902 6000, USA
Alcohol Clin Exp Res 32:294-305. 2008..Therefore, the present study compared responsiveness to ethanol and solutions with bitter (quinine) and sweet (saccharin) taste in terms of intake and palatability across the first 2 weeks of postnatal life.
- Pilot feasibility study of an emergency paediatric kit for intra-rectal quinine administration used by the personnel of community-based health care units in SenegalJean Louis A Ndiaye
Service de Parasitologie, Faculte de Medecine, université Cheikh Anta Diop de Dakar, Senegal
Malar J 6:152. 2007b>Quinine injection is the reference treatment for malaria when oral administration is impossible...
- In vitro monitoring of Plasmodium falciparum drug resistance in French Guiana: a synopsis of continuous assessment from 1994 to 2005Eric Legrand
Reference Centre for Plasmodium Chemoresistance in French Guiana and West Indies CNRCP, Institut Pasteur de la Guyane, Cayenne, French Guiana
Antimicrob Agents Chemother 52:288-98. 2008..The quinine-doxycycline combination was introduced in 1995 as the first-line drug treatment against uncomplicated P...
- Determination of cinchona alkaloids by non-aqueous CE with MS detectionWolfgang Buchberger
Institute of Analytical Chemistry, Johannes Kepler University, Linz, Austria
Electrophoresis 31:1208-13. 2010Non-aqueous CZE was investigated for separation of cinchona alkaloids including diastereomeric pairs of analytes such as quinine/quinidine or cinchonine/cinchonidine...
- Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopeniaDaniel W Bougie
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
Blood 113:1105-11. 2009..1 and 314.3, from a mouse immunized with purified human GPIIb/IIIa and quinine that recognize the N terminus of the GPIIb beta propeller domain only when soluble quinine is present...
- Riboflavin-binding protein is a novel bitter inhibitorKenji Maehashi
Department of Fermentation Science, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo, Japan
Chem Senses 33:57-63. 2008..RBP elicited broadly tuned inhibition of various bitter substances including quinine-HCl, naringin, theobromine, caffeine, glycyl-L-phenylalanine (Gly-Phe), and denatonium benzoate, whereas several ..
- Quinine carbamate chiral stationary phases: systematic optimization of steric selector-selectand binding increments and enantioselectivity by quantitative structure-enantioselectivity relationship studiesMichael Lämmerhofer
Christian Doppler Laboratory for Molecular Recognition Materials, Department of Analytical Chemistry, University of Vienna, Vienna, Austria
J Sep Sci 29:1486-96. 2006A series of quinine carbamate-based chiral stationary phases (CSPs) differing solely in the carbamate residue have been devised and a congeneric set of N-3,5-dinitrobenzoyl (DNB) amino acids (AAs) was separated into enantiomers on these ..
- Activation by bitter substances of a cationic channel in membrane patches excised from the bullfrog taste receptor cellT Tsunenari
Department of Physiology, Keio University School of Medicine, Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
J Physiol 519:397-404. 1999..2. Application of a bitter-tasting substance, quinine or denatonium, induced channel openings under conditions in which none of the second messenger candidates or ..
- Quinine versus carbamoylated quinine-based chiral anion exchangers. A comparison regarding enantioselectivity for N-protected amino acids and other chiral acidsA Mandl
Institute of Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Austria
J Chromatogr A 858:1-11. 1999First, a chiral stationary phase was prepared by immobilization of the naturally occurring alkaloid quinine onto a 3-mercaptopropyl-modified silica gel via a radical addition reaction and it was evaluated for direct HPLC ..
- Stability, compatibility and plasticizer extraction of quinine injection added to infusion solutions and stored in polyvinyl chloride (PVC) containersM A Faouzi
Laboratoire de Pharmacologie, Pharmacocinetique et Pharmacie Clinique, Faculte des Sciences Pharmaceutiques et Biologiques, Lille, France
J Pharm Biomed Anal 21:923-30. 1999The stability of quinine was determined in various diluents and in polyvinyl chloride (PVC) containers. The release of diethyhexyl phthalate (DEHP) from PVC bags into intravenous infusions of quinine was also measured...
- Further characterization of the quinine taste discrimination stimulus in rhesus monkeys: effects of inter-trial interval, number and distribution of test stimuliJ A Vivian
Department of Pharmacology, University of Michigan, Ann Arbor, USA
Behav Pharmacol 10:313-8. 1999..purpose of the current investigation was to characterize further the taste discriminative stimulus properties of quinine. Using a food-maintained two-choice (quinine and water) discrimination paradigm, the effects of varying inter-..
- [Tolerance of quinine administered as an intrarectal solution in children in French-speaking Africa]H Barennes
Unité d Epidémiologie d Intervention, Centre Muraz, Bobo Dioulasso, Burkina Faso
Med Trop (Mars) 59:383-8. 1999Pharmacokinetic studies have documented the efficacy of intrarectal quinine (IRQ) for treatment of childhood malaria...
- Effect of extracellular Ca2+ on the quinine-activated current of bullfrog taste receptor cellsT Tsunenari
Department of Physiology, Keio University School of Medicine, Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
J Physiol 530:235-41. 2001The bitter substance quinine activates a cation current from the frog taste receptor cell...
- Clinical trial of beta-arteether versus quinine for the treatment of cerebral malaria in children in Yaounde, CameroonR Moyou-Somo
Institute of Medical Research and Study of Medicinal Plants Medical Research Center, Yaounde, Cameroon, West Africa
Am J Trop Med Hyg 64:229-32. 2001..2 mg/kg on Day 0, followed by 1.6 mg/kg on Days 1 to 4) or intravenous (i.v.) quinine dihydrochloride (20 mg of the salt/kg, followed by 10 mg of the salt/kg every 8 hr up to Day 6)...
- Quinine blocks specific gap junction channel subtypesM Srinivas
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 98:10942-7. 2001We demonstrate that the antimalarial drug quinine specifically reduces currents through gap junctions formed by some connexins (Cx) in transfected mammalian cells, but does not affect other gap junction types...
- Quinine for nocturnal leg cramps: a meta-analysis including unpublished dataM Man-Son-Hing
Department of Medicine, University of Ottawa, Ont, Canada
J Gen Intern Med 13:600-6. 1998OBJECTIVE: With respect to the use of quinine for the treatment of nocturnal leg cramps, to determine whether the findings of a previously performed meta-analysis of published data are altered with the addition of unpublished data, and ..
- Response of uncomplicated falciparum malaria to oral chloroquine and quinine in Burundi highlandsG Di Perri
Istituto di Immunologia e Malattie Infettive, , Ospedale Civile Maggiore, Italy
Acta Trop 70:25-33. 1998The in vivo response of falciparum malaria to oral chloroquine and quinine was evaluated in two identical hospital-based, comparative open trials carried out 2 years apart in the same seasonal period at a hospital located in the ..
- Pharmacological characterization of muscarinic receptor-activated cation channels in guinea-pig ileumS Chen
Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Br J Pharmacol 109:793-801. 1993..2. Well-known K channel blockers, tetraethylammonium (TEA), 4-aminopyridine (4-AP), procaine and quinine as well as a Ca releasing agent, caffeine, all produced concentration-dependent inhibition of Icat with rapid ..
- Therapeutic effects of chloroquine in combination with quinine in uncomplicated falciparum malariaS Vanijanonta
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Bangkok, Thailand
Ann Trop Med Parasitol 90:269-75. 1996The efficacy and toxicity of oral quinine combined with oral chloroquine were studied in 50 Thai men with uncomplicated falciparum malaria. All were treated for 7 days with quinine sulphate (10 mg salt/kg every 8 h)...
- Anticipatory contrast effect in rats: a new view with lick response analysis and the effect of dopamine blockingB H Chen
Department of Psychology, National Chung Cheng University, Chia Yi, Taiwan, ROC
Chin J Physiol 39:235-43. 1996..008% quinine (A), 8% sucrose with 0.002% quinine (B), and 32% sucrose with 0.008% quinine (C)...
- Purification and characterization of two isoforms of isopentenyl-diphosphate isomerase from elicitor-treated Cinchona robusta cellsA C Ramos-Valdivia
Division of Pharmacognosy, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
Eur J Biochem 249:161-70. 1997In Cinchona robusta (Rubiaceae) cell suspension cultures, the activity of the enzyme isopentenyl-diphosphate isomerase (isopentenyl-POP isomerase) is transiently induced after addition of a homogenate of the phytopathogenic fungus ..
- Intramuscular artemether vs intravenous quinine: an open, randomized trial in Malawian children with cerebral malariaT E Taylor
Wellcome Trust Centre, Queen Elizabeth Central Teaching Hospital, Blantyre, Malawi
Trop Med Int Health 3:3-8. 1998OBJECTIVES: To compare artemether (by intramuscular injection) and quinine (by intravenous infusion) as treatments for cerebral malaria in African children...
- Salicylate and quinine selectively increase spontaneous firing rates in secondary auditory cortexJ J Eggermont
Department of Physiology and Biophysics, The University of Calgary, Alta, Canada
Hear Res 117:149-60. 1998..auditory field (AAF) and secondary auditory cortex (AII) in cats before and after application of salicylate or quinine. From 21 cats, in three cortical areas simultaneously, a total of 1533 multi-unit files were obtained...
- Effect of artemether on electrocardiogram in severe falciparum malariaJ Karbwang
Clinical Pharmacology Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 28:472-5. 1997..intramuscular loading dose of 160 mg, followed by 80 mg daily for another 6 doses), in comparison with that of quinine (intravenous infusion of loading dose of 20 mg/kg, followed by 10 mg/kg q 8 hourly for 7 days), on the ..
- Randomized comparison of intramuscular artemether and intravenous quinine in adult, Melanesian patients with severe or complicated, Plasmodium falciparum malaria in Papua New GuineaR A Seaton
Department of Clinical Sciences, University of Papua New Guinea, Port Moresby, Papua, New Guinea
Ann Trop Med Parasitol 92:133-9. 1998..2 mg/kg, followed by 1.6 mg/kg daily for 4 days) and intravenous quinine (a loading dose of 20 mg quinine dihydrochloride/kg, followed first by 10 mg/kg every 8 h, each injection taking ..
- New Antimalarials from Plant-Pathogenic FungiNP NANAYAKKARA; Fiscal Year: 2005..Natural products isolated from higher plants, such as quinine and artemisinin, have provided effective drugs against malaria...
- MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUMTim Anderson; Fiscal Year: 2004..We will measure in vitro susceptibility to 4 important antimalarial compounds-mefloquine, quinine, artemisinin and chloroquine in malaria parasites obtained from a site on the Thai-Burmese border...
- MALARIA CHEMOTHERAPY AND CHEMOPROTECTIONGary Posner; Fiscal Year: 2000Among infectious diseases, malaria is common in many parts of the world. Standard alkaloids such as quinine and chloroquine are becoming less and less effective because malaria parasites are developing resistance to such drugs...
- Effects of expectation on gustatory cortical activityAlfredo Fontanini; Fiscal Year: 2009..in which one tone cues the availability of a palatable taste (sucrose or NaCl) and the other a punishment (quinine) at a press of a lever, will reveal the effects of expectation of particular tastes having opposite affective ..
- Effects of expectation on gustatory cortical activityAlfredo Fontanini; Fiscal Year: 2010..in which one tone cues the availability of a palatable taste (sucrose or NaCl) and the other a punishment (quinine) at a press of a lever, will reveal the effects of expectation of particular tastes having opposite affective ..
- Evolutionary Dissection of complex traitsStephen Wooding; Fiscal Year: 2007..Many well-known bitter compounds such as quinine, nicotine, and caffeine, for example, are toxins produced naturally by plants...
- HIGH-THROUGHPUT SCEENS FOR ASSESSING TASTE SENSITIVITYJOHN GLENDINNING; Fiscal Year: 2001..Because this screen will be conducted with an expansive array of concentrations of each taste stimulus (quinine, NaCl, and sucrose), it will be able to detect gross and subtle alterations in taste sensitivity in either ..
- ASYMMETRIC 1,2-ADDITIONSDAVID COLLUM; Fiscal Year: 2001..While the highly selective additions to imines behave quite differently from the additions to ketones (requiring lithiated quinine or quinidine), the strategies and analytical methods used to study them will be similar.
- Combined Voltammetry/Electrophysiology in Behaving RatsRegina M Carelli; Fiscal Year: 2010..aversive (quinine) tastant...
- Immune Dysregulation in HITGowthami Arepally; Fiscal Year: 2009..disorder, its immunologic features bear little resemblance to other commonly encountered drug allergies, like quinine or penicillin...
- Immune Dysregulation in HITGowthami M Arepally; Fiscal Year: 2010..disorder, its immunologic features bear little resemblance to other commonly encountered drug allergies, like quinine or penicillin...
- Combined Voltammetry/Electrophysiology in Behaving RatsREGINA CARELLI; Fiscal Year: 2009..aversive (quinine) tastant...
- MODULATION OF TASTE RESPONSES BY THE TRIGEMINAL SYSTEMSIDNEY SIMON; Fiscal Year: 2004..That in turn will modulate the activity of CT neurons to lingual applications of NaCl, acid, sucrose, and quinine. This hypothesis will be tested by activating the TG nerve electrically and chemically (e.g...
- Temporal Coding in the Gustatory System of the BrainPatricia M Di Lorenzo; Fiscal Year: 2011..pattern of electrical stimulation can mimic the perceptual properties and behavioral reactivity of either quinine or sucrose and b) construct a temporal sequence of electrical pulses which incorporates the critical features of ..
- PERIPHERAL GUSTATORY PROCESSINGMARION FRANK; Fiscal Year: 2007..inhibition in peripheral mixture processing by testing the ability of hamsters to recognize components in sucrose-quinine, dulcin-quinine and sucrose-quinine-NaCI mixtures...
- PERIPHERAL GUSTATORY PROCESSINGMARION FRANK; Fiscal Year: 2007..inhibition in peripheral mixture processing by testing the ability of hamsters to recognize components in sucrose-quinine, dulcin- quinine and sucrose-quinine-NaCI mixtures...
- PERIPHERAL GUSTATORY PROCESSINGMARION FRANK; Fiscal Year: 2009..inhibition in peripheral mixture processing by testing the ability of hamsters to recognize components in sucrose-quinine, dulcin-quinine and sucrose-quinine-NaCI mixtures...
- PERIPHERAL GUSTATORY PROCESSINGMARION ELIZABETH FRANK; Fiscal Year: 2010..inhibition in peripheral mixture processing by testing the ability of hamsters to recognize components in sucrose-quinine, dulcin-quinine and sucrose-quinine-NaCI mixtures...
- PERIPHERAL GUSTATORY PROCESSINGMARION FRANK; Fiscal Year: 2003..Hamster CT and GL nerve fibers respond to sucrose, sodium chloride, hydrochloric acid and quinine. HCl (QHCl) but greater than 75 percent of CT fibers are sucrose-best (S) or NaCl-best (N) and greater than 75 ..
- Asymmetric Reactions with Bifunctional OrganocatalysisLi Deng; Fiscal Year: 2009..the last several years our research program has made signiificant progress in the development and application of cinchona alkaloids as broadly useful chiral base/nucleophilic catalysts for asymmetric synthesis and in the elucidation of ..
- Asymmetric Reactions with Bifunctional OrganocatalysisLi Deng; Fiscal Year: 2010..the last several years our research program has made signiificant progress in the development and application of cinchona alkaloids as broadly useful chiral base/nucleophilic catalysts for asymmetric synthesis and in the elucidation of ..
- Asymmetric Reactions with Bifunctional OrganocatalysisLi Deng; Fiscal Year: 2007..the last several years our research program has made significant progress in the development and application of cinchona alkaloids as broadly useful chiral base/nucleophilic catalysts for asymmetric synthesis and in the elucidation of ..
- FUNCTIONAL ORGANIZATION OF PERIPHERAL GUSTATORY SYSTEMALAN SPECTOR; Fiscal Year: 2006..nucleus of the solitary tract [NST] (as assessed by Fos-like immunoreactivity) stimulated by oral application of quinine. The purpose of the research here is to extend these findings in new and important ways to help clarify the ..
- FUNCTIONAL ORGANIZATION OF PERIPHERAL GUSTATORY SYSTEMALAN SPECTOR; Fiscal Year: 2007..nucleus of the solitary tract [NST] (as assessed by Fos-like immunoreactivity) stimulated by oral application of quinine. The purpose of the research here is to extend these findings in new and important ways to help clarify the ..