quinine

Summary

Alias: cinchona

Top Publications

  1. ncbi UK malaria treatment guidelines
    David G Lalloo
    Clinical Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    J Infect 54:111-21. 2007
  2. ncbi Quality evaluation of chloroquine, quinine, sulfadoxine-pyrimethamine and proguanil formulations sold on the market in East Congo DR
    M A Atemnkeng
    Pharmaceutical Technology and Physical Pharmacy Department, Pharmaceutical Institute, Vrije Universiteit Brussel, Brussels, Belgium
    J Clin Pharm Ther 32:123-32. 2007
  3. ncbi The effect of mimicking febrile temperature and drug stress on malarial development
    Ratchaneewan Aunpad
    Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand
    Ann Clin Microbiol Antimicrob 8:19. 2009
  4. ncbi [In vitro susceptibility of P. falciparum isolates from Abidjan (Côte d'Ivoire) to quinine, artesunate and chloroquine]
    André Offianan Touré
    Institut Pasteur de Côte d Ivoire, Unité de Paludologie, 01 BP 490 Abidjan 01, Ivory Coast
    Sante 18:43-7. 2008
  5. ncbi Anti-filarial effects of nine quinoline-containing drugs on adult filariae in vitro
    E A Vandewaa
    Department of Microbiology and Public Health, Michigan State University, East Lansing 48824
    J Parasitol 75:367-72. 1989
  6. ncbi Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6
    S W Ellis
    Section of Molecular Pharmacology and Pharmacogenetics, L Floor, Royal Hallamshire Hospital, Glossop Road, University of Sheffield, Sheffield S10 2JF, U K
    Biochem J 345:565-71. 2000
  7. ncbi Differential effects of salicylate, quinine, and furosemide on Guinea pig inner and outer hair cell function revealed by the input-output relation of the auditory brainstem response
    Martin Pienkowski
    Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm
    J Am Acad Audiol 22:104-12. 2011
  8. ncbi In vitro study assessing the response of plasmodium falciparum malaria to chloroquine, sulfadoxine/pyrimethamine, quinine and mefloquine in Wad Medani District, Sudan
    Bakri Y Nour
    Faculty of Medicine, Blue Nile Research and Training Institute, University of Gezira, PO Box 101, Wad Medani, Sudan
    Saudi Med J 27:808-12. 2006
  9. ncbi Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40
    S J Cook
    School of Biological Sciences, University of Manchester
    Br J Pharmacol 114:143-51. 1995
  10. ncbi Susceptibility of Malaysian Plasmodium falciparum isolates to antimalarial drugs after cryopreservation and 12 months of continuous in vitro culture
    H H Ang
    School of Pharmaceutical Sciences, University of Science Malaysia, Penang
    Chemotherapy 43:311-5. 1997

Research Grants

  1. New Antimalarials from Plant-Pathogenic Fungi
    NP NANAYAKKARA; Fiscal Year: 2005
  2. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2004
  3. MALARIA CHEMOTHERAPY AND CHEMOPROTECTION
    Gary Posner; Fiscal Year: 2000
  4. Effects of expectation on gustatory cortical activity
    Alfredo Fontanini; Fiscal Year: 2009
  5. Effects of expectation on gustatory cortical activity
    Alfredo Fontanini; Fiscal Year: 2010
  6. Evolutionary Dissection of complex traits
    Stephen Wooding; Fiscal Year: 2007
  7. HIGH-THROUGHPUT SCEENS FOR ASSESSING TASTE SENSITIVITY
    JOHN GLENDINNING; Fiscal Year: 2001
  8. ASYMMETRIC 1,2-ADDITIONS
    DAVID COLLUM; Fiscal Year: 2001
  9. Combined Voltammetry/Electrophysiology in Behaving Rats
    Regina M Carelli; Fiscal Year: 2010
  10. Immune Dysregulation in HIT
    Gowthami Arepally; Fiscal Year: 2009

Detail Information

Publications122 found, 100 shown here

  1. ncbi UK malaria treatment guidelines
    David G Lalloo
    Clinical Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    J Infect 54:111-21. 2007
    ..Uncomplicated P. falciparum malaria can be treated orally with quinine, atovaquone plus proguanil (Malarone) or co-artemether (Riamet); quinine is highly effective but poorly tolerated ..
  2. ncbi Quality evaluation of chloroquine, quinine, sulfadoxine-pyrimethamine and proguanil formulations sold on the market in East Congo DR
    M A Atemnkeng
    Pharmaceutical Technology and Physical Pharmacy Department, Pharmaceutical Institute, Vrije Universiteit Brussel, Brussels, Belgium
    J Clin Pharm Ther 32:123-32. 2007
    ..Eur.). The second aim was to check the extent to which simple methods of analysis could be used to evaluate drug quality...
  3. ncbi The effect of mimicking febrile temperature and drug stress on malarial development
    Ratchaneewan Aunpad
    Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand
    Ann Clin Microbiol Antimicrob 8:19. 2009
    ..These trigger malarial evolutionarily adaptive responses. The effect of febrile temperature on malarial growth, development and drug susceptibility by mimicking patient in treatment failure before and after drug uptake was examined...
  4. ncbi [In vitro susceptibility of P. falciparum isolates from Abidjan (Côte d'Ivoire) to quinine, artesunate and chloroquine]
    André Offianan Touré
    Institut Pasteur de Côte d Ivoire, Unité de Paludologie, 01 BP 490 Abidjan 01, Ivory Coast
    Sante 18:43-7. 2008
    ..These make it possible to detect changes in susceptibility and are expected to prevent the emergence of resistance against the most recently introduced combined therapy...
  5. ncbi Anti-filarial effects of nine quinoline-containing drugs on adult filariae in vitro
    E A Vandewaa
    Department of Microbiology and Public Health, Michigan State University, East Lansing 48824
    J Parasitol 75:367-72. 1989
    ..chloroquine, (bis)desethylchloroquine, SN6911, SN12108, amodiaquine, CN-2999-2K, primaquine, quinacrine, and quinine were examined in vitro against adult female Brugia pahangi...
  6. ncbi Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6
    S W Ellis
    Section of Molecular Pharmacology and Pharmacogenetics, L Floor, Royal Hallamshire Hospital, Glossop Road, University of Sheffield, Sheffield S10 2JF, U K
    Biochem J 345:565-71. 2000
    ..in substrate enantioselectivity and the differential inhibition of enzyme activity by the diastereoisomers quinine and quinidine...
  7. ncbi Differential effects of salicylate, quinine, and furosemide on Guinea pig inner and outer hair cell function revealed by the input-output relation of the auditory brainstem response
    Martin Pienkowski
    Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm
    J Am Acad Audiol 22:104-12. 2011
    ..There have been a number of attempts to differentiate between these etiologies of hearing loss, using various psychoacoustic and physiologic paradigms...
  8. ncbi In vitro study assessing the response of plasmodium falciparum malaria to chloroquine, sulfadoxine/pyrimethamine, quinine and mefloquine in Wad Medani District, Sudan
    Bakri Y Nour
    Faculty of Medicine, Blue Nile Research and Training Institute, University of Gezira, PO Box 101, Wad Medani, Sudan
    Saudi Med J 27:808-12. 2006
    To assess the in vitro response of Plasmodium falciparum malaria to chloroquine (CQ), sulfadoxine/pyrimethamine (SDX/PYR), Quinine (QU) and Mefloquine (MQ) and monitoring their resistance.
  9. ncbi Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40
    S J Cook
    School of Biological Sciences, University of Manchester
    Br J Pharmacol 114:143-51. 1995
    ..4. Quinine (30 microM) caused little or no change in tissue tone and did not modify the relaxant action of isoprenaline...
  10. ncbi Susceptibility of Malaysian Plasmodium falciparum isolates to antimalarial drugs after cryopreservation and 12 months of continuous in vitro culture
    H H Ang
    School of Pharmaceutical Sciences, University of Science Malaysia, Penang
    Chemotherapy 43:311-5. 1997
    ..0 and 690.1 for chloroquine; 3.4, 3.4, 9.2, 4.0 and 5.8 for mefloquine; 21.9, 10.5, 40.7, 40.1 and 48.7 for quinine; 136.7, 58.8, 116.4, 29.4 and 95.4 for cycloguanil, and 48.3, 57.5, 47.4, 61.5 and 37.8 for pyrimethamine...
  11. ncbi Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. II. Electrophysiological and fluorimetric studies
    I Rustenbeck
    Institute of Clinical Biochemistry, Hannover Medical School, D 30623, Hannover, Germany
    Biochem Pharmacol 62:1695-703. 2001
    ..secretagogues that block ATP-dependent K(+) channels (K(ATP) channels), such as sulfonylureas, imidazolines, and quinine, induced a desensitization of insulin secretion (Rustenbeck et al., pages 1685-1694, this issue)...
  12. ncbi A nationwide survey of the quality of antimalarials in retail outlets in Tanzania
    Harparkash Kaur
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    PLoS ONE 3:e3403. 2008
    ..This study aimed to assess the quality of antimalarials available from retail outlets across mainland Tanzania...
  13. ncbi Compliance with artesunate and quinine + tetracycline treatment of uncomplicated falciparum malaria in Thailand
    W Fungladda
    Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Bull World Health Organ 76:59-66. 1998
    A randomized, controlled, malaria-clinic-based field trial was conducted to compare compliance with a 7-day quinine + tetracycline regimen and a 5-day 700-mg artesunate regimen for the treatment of uncomplicated falciparum malaria in a ..
  14. ncbi Drug-induced immune thrombocytopenia
    Patricia M L A van den Bemt
    Hospital Pharmacy Midden Brabant, TweeSteden Hospital and St Elisabeth Hospital, Tilburg, The Netherlands
    Drug Saf 27:1243-52. 2004
    ..The drug classes that are most often associated with drug-induced immune thrombocytopenia are cinchona alkaloid derivatives (quinine, quinidine), sulfonamides, NSAIDs, anticonvulsants, disease modifying antirheumatic ..
  15. ncbi The historical aspects of sunscreens
    F Urbach
    Charles River Laboratories Inc, Argus Division, 905 Sheehy Drive, Horsham, PA 19044, USA
    J Photochem Photobiol B 64:99-104. 2001
    ..Hygiea, Festband #3, Samson and Wallin, Stockholm) used acidified quinine sulfate to absorb UVB, apparently because, since quinine fluoresces when irradiated with UVR, he rightly assumed ..
  16. ncbi Atovaquone and azithromycin for the treatment of babesiosis
    P J Krause
    Division of Infectious Diseases, Connecticut Children s Medical Center and the University of Connecticut School of Medicine, Hartford 06106, USA
    N Engl J Med 343:1454-8. 2000
    ..A course of clindamycin and quinine is the standard treatment, but this regimen frequently causes adverse reactions and occasionally fails...
  17. ncbi Taste masking analysis in pharmaceutical formulation development using an electronic tongue
    Jack Y Zheng
    Pharmaceutical Sciences R and D, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46225, USA
    Int J Pharm 310:118-24. 2006
    ..Taste-masking efficiency was evaluated using quinine as a bitter model compound and a sweetener, acesulfame K, as a bitterness inhibitor. In a 0...
  18. ncbi The effects of rubidium, caesium and quinine on 5-HT-mediated behaviour in rat and mouse--3. Quinine
    H Wang
    MRC Unit, Radcliffe Infirmary, Oxford, U K
    Neuropharmacology 31:425-31. 1992
    It has been shown that caesium, which shares properties with quinine as a K(+)-channel blocker, enhanced 5-HT-mediated behaviour in both rats and mice...
  19. ncbi Liquid chromatographic analysis of cinchona alkaloids in beverages
    Masao Horie
    Tokyo Metropolitan Institute of Public Health, Department of Food Safety, 3 24 1 Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    J AOAC Int 89:1042-7. 2006
    A method for the determination of Cinchona extract (whose main components are the alkaloids cinchonine, cinchonidine, quinidine, and quinine) in beverages by liquid chromatography was developed...
  20. ncbi Quinine-induced disseminated intravascular coagulation: case report and review of the literature
    Mark T Knower
    Section on Pulmonary and Critical Care, Ochsner Clinic North Shore, 804 Heavens Drive, Suite 105, Mandeville, LA 70471, USA
    Intensive Care Med 29:1007-11. 2003
    To describe the clinical course of quinine-induced disseminated intravascular coagulation (DIC) and review all previous cases reported in the medical literature.
  21. ncbi Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification
    Russell S J Keast
    Food Science, RMIT University, Cnr Russell and Victoria St, Melbourne, Victoria 3001, Australia
    Pharm Res 22:1970-7. 2005
    Zinc sulfate is known to inhibit the bitterness of the antimalarial agent quinine [R. S. J. Keast. The effect of zinc on human taste perception. J. Food Sci. 68:1871-1877 (2003)]...
  22. ncbi The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT3 receptors
    A J Thompson
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Br J Pharmacol 151:666-77. 2007
    The antimalarial compounds quinine, chloroquine and mefloquine affect the electrophysiological properties of Cys-loop receptors and have structural similarities to 5-HT(3) receptor antagonists. They may therefore act at 5-HT(3) receptors.
  23. ncbi A comparative study of artesunate and artemether in combination with mefloquine on multidrug resistant falciparum malaria in eastern Thailand
    K Thimasarn
    Department of Communicable Disease Control, Ministry of Public Health, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 28:465-71. 1997
    ..in Thailand is highly resistant to chloroquine, sulfadoxine-pyrimethamine and there is increasing resistance to quinine and mefloquine...
  24. ncbi Efficacies of chloroquine, sulfadoxine-pyrimethamine and quinine in the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan
    I Adam
    New Halfa Teaching Hospital, P O Box 61, New Halfa, Sudan
    Ann Trop Med Parasitol 98:661-6. 2004
    ..completed the 28 days of follow-up were treated with chloroquine (N = 26), sulfadoxine-pyrimethamine (N = 38) or quinine (N = 32). No treatment failures were observed among the patients given sulfadoxine-pyrimethamine. Only 23...
  25. ncbi In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya
    John Okombo
    Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Program, P O Box 230, 80108 Kilifi, Kenya
    Antimicrob Agents Chemother 54:3302-7. 2010
    Resistance to the amino alcohol quinine has been associated with polymorphisms in pfnhe, a sodium hydrogen exchanger. We investigated the role of this gene in quinine resistance in vitro in isolates from Kenya...
  26. ncbi Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. I. Secretory and morphological studies
    I Rustenbeck
    Institute of Clinical Biochemistry, Hannover Medical School, D 30623, Hannover, Germany
    Biochem Pharmacol 62:1685-94. 2001
    ..of the well-characterized sulfonylurea, tolbutamide (500 microM), and those of the ion channel-blocking alkaloid, quinine (100 microM)...
  27. ncbi Beta-cell toxicity of ATP-sensitive K+ channel-blocking insulin secretagogues
    Ingo Rustenbeck
    Institute of Pharmacology and Toxicology, Technical University of Braunschweig, D 38106 Braunschweig, Germany
    Biochem Pharmacol 67:1733-41. 2004
    ..phentolamine, alinidine and idazoxan (100microM each), the sulfonylurea tolbutamide (500microM), or the alkaloid quinine (100microM) resulted in morphological damage of 4-18% of beta-cells compared to less than 2% in controls...
  28. ncbi The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes
    Magnus Christensen
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Clin Pharmacol Ther 73:517-28. 2003
    ..were (1) to determine whether the drugs caffeine, losartan, omeprazole, debrisoquin (INN, debrisoquine), and quinine can be given simultaneously in low doses as a cocktail for the phenotyping of cytochrome P450 (CYP) 1A2, 2C9, ..
  29. ncbi Drug-resistant malaria in Bangui, Central African Republic: an in vitro assessment
    Didier Menard
    Pasteur Institute of Bangui, Bangui, Central African Republic
    Am J Trop Med Hyg 73:239-43. 2005
    ..We tested antimalarials that are currently in use in this country (chloroquine, amodiaquine, quinine, and pyrimethamine), antimalarials that will become available in this region in the future (artemisinin and ..
  30. ncbi Barium- or quinine-induced depolarization activates K+, Na+ and cationic conductances in frog proximal tubular cells
    F Discala
    INSERM U 323, Faculte de Medecine Necker Enfants Malades, Paris, France
    J Physiol 448:525-37. 1992
    ..tK went up to 0.83. 4. The high tK preparation was challenged with barium (3 mM) or quinine (Quin, 1 mM)...
  31. ncbi Quinoline antimalarials decrease the rate of beta-hematin formation
    Timothy J Egan
    Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa
    J Inorg Biochem 99:1532-9. 2005
    ..or malaria pigment) formation by the quinoline antimalarial drugs chloroquine, amodiaquine, quinidine and quinine has been investigated as a function of incubation time...
  32. ncbi Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers
    Annika Allqvist
    Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Pharmacology at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Eur J Clin Pharmacol 63:173-9. 2007
    ..Most of them, however, involved the KTZ racemate. KTZ racemate and the separate enantiomers, 2R,4R; 2R,4S; 2S,4S, and 2S,4R, were evaluated for their selectivity in inhibiting alprazolam and quinine metabolism.
  33. ncbi Quantitative trait loci associated with short-term intake of sucrose, saccharin and quinine solutions in laboratory mice
    D A Blizard
    Center for Developmental and Health Genetics and Intercollege Graduate Program in Genetics, The Pennsylvania State University, University Park 16802, USA
    Chem Senses 24:373-85. 1999
    ..to map two genetic loci which, collectively, have a large effect on intake of sucrose, saccharin and quinine solutions in mice...
  34. ncbi Exposure to sucrose-quinine solutions does not increase ethanol consumption
    C J Slawecki
    Department of Physiology and Pharmacology, The Wake Forest University School of Medicine, Winston Salem, NC, USA
    Alcohol 16:329-35. 1998
    ..The consumption of 0-20% ethanol was then determined before and after exposure to a sucrose-quinine solution...
  35. ncbi Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: a randomized, phase 2 clinical trial in Thailand
    Harald Noedl
    1Department of Immunology and Medicine, USAMC AFRIMS, Bangkok, Thailand
    Clin Infect Dis 43:1264-71. 2006
    ..Azithromycin is a macrolide antibiotic that is particularly attractive as an antimalarial because of its safety in children and the extensive experience with its use during pregnancy...
  36. ncbi Myosin II-dependent cylindrical protrusions induced by quinine in Dictyostelium: antagonizing effects of actin polymerization at the leading edge
    K Yoshida
    Department of Botany, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Cell Sci 114:2155-65. 2001
    We found that amoeboid cells of Dictyostelium are induced by a millimolar concentration of quinine to form a rapidly elongating, cylindrical protrusion, which often led to sustained locomotion of the cells...
  37. ncbi Stimulation of bitterness by capsaicin and menthol: differences between lingual areas innervated by the glossopharyngeal and chorda tympani nerves
    Barry G Green
    The John B Pierce Laboratory, Yale School of Medicine, 290 Congress Avenue, New Haven, CT 06519, USA
    Chem Senses 28:45-55. 2003
    ..Sucrose, citric acid, sodium chloride and quinine hydrochloride were applied to the same areas to assess tastes responsiveness...
  38. ncbi Antimalarial drugs inhibit human 5-HT(3) and GABA(A) but not GABA(C) receptors
    A J Thompson
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Br J Pharmacol 153:1686-96. 2008
    ..Here, we extend these studies to include human 5-HT(3A), 5-HT(3AB), GABA(A) alpha1beta2, GABA(A) alpha1beta2gamma2 and GABA(C) rho1 receptors...
  39. ncbi Acceptability and efficacy of intra-rectal quinine alkaloids as a pre-transfer treatment of non-per os malaria in peripheral health care facilities in Mopti, Mali
    Mahamadou A Thera
    Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases DEAP Faculty of Medicine, Pharmacy and Odonto Stomatologie, University of Bamako, Bamako, Mali
    Malar J 6:68. 2007
    The acceptability and efficacy of a new kit with a new formulation of quinine alkaloids designed for the intra-rectal administration in the treatment of non-per os malaria was assessed in the peripheral health care system of Mopti, Mali.
  40. ncbi Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice
    Krisztina M Kovacs
    Laboratory of Neurobehavioral GeneticsNathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 29:730-8. 2005
    ..Here we examined the effects of targeted disruption of kappa-opioid receptor (KOR) on oral alcohol self-administration and other behaviors...
  41. ncbi Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial
    Robert Gurkov
    Department of Otorhinolaryngology Head and Neck Surgery, Ludwig Maximilians University, Munich, Germany
    Malar J 7:179. 2008
    ..The aim of the study was to compare ototoxicity, tolerability, and efficacy of ACT with that of quinine and atovaquone/proguanil in the treatment of uncomplicated falciparum malaria.
  42. ncbi [Intrarectal administration of quinine: an early treatment for severe malaria in children?]
    H Barennes
    Centre Muraz, BP 153, Bobo Dioulasso, Burkina Faso
    Sante 11:145-53. 2001
    ..We recently showed the kinetic profile, the optimal regimen and the clinical efficacy of intrarectal quinine (QIR) using Quinimax (Sanofi, Gentilly France) 20 mg/kg in solution with 2 ml of water...
  43. ncbi [Limits of the efficacy of chloroquine and sulfadoxine-pyrimethamine in Northern Abidjan (Cote d'Ivoire): Combined in vivo and in vitro studies]
    Joseph Djaman
    Unite de Parasitologie, Laboratoire de microbiologie de l Institut national de santé publique Abidjan, BP V 47 Abidjan Laboratoire de pharmacodynamie biochimique, UFR Biosciences, Universite de Cocody, Abidjan, Cote d Ivoire
    Sante 14:205-9. 2004
    ..falciparum isolates were cultured in the presence of variable concentrations of chloroquine, pyrimethamine and quinine during in vitro chemosensitivity tests...
  44. ncbi Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain
    Jose A Sanchez-Chapula
    Unidad de Investigación Carlos Méndez del Centro Universitario de Investigaciones Biomédicas de la Universidad de Colima, Colima, Mexico
    Mol Pharmacol 63:1051-8. 2003
    ..The IC(50) values determined with voltage-clamp pulses to 0 mV were 4.6 microM and 57 microM for quinidine and quinine, respectively...
  45. ncbi Crystal structure of (-)-mefloquine hydrochloride reveals consistency of configuration with biological activity
    Jean M Karle
    Department of Medicinal Chemistry, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 7500, USA
    Antimicrob Agents Chemother 46:1529-34. 2002
    ..the hydrochloride salt, thus allowing comparison of the configuration of mefloquine's optical isomers to those of quinine and quinidine...
  46. ncbi Skin permeation enhancement potential of Aloe Vera and a proposed mechanism of action based upon size exclusion and pull effect
    Louise Cole
    Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, United Kingdom
    Int J Pharm 333:10-6. 2007
    ..Saturated solutions of caffeine, colchicine, mefenamic acid, oxybutynin, and quinine were prepared at 32 degrees C in Aloe Vera juice and water (control) and used to dose porcine ear skin mounted in ..
  47. ncbi Quinine-induced arrhythmia in a patient with severe malaria
    Carta A Gunawan
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine Mulawarman University A Wahab Sjahranie General Hospital, Samarinda
    Acta Med Indones 39:27-32. 2007
    ..malaria patient with jaundice who presented with arrhythmia (premature ventricular contraction) while getting quinine infusion was reported. A man, 25 years old, was admitted to hospital with high fever, chill, vomiting, jaundice...
  48. ncbi Taste-masked quinine sulphate pellets: bio-availability in adults and steady-state plasma concentrations in children with uncomplicated Plasmodium falciparum malaria
    P C Kayumba
    Department of Pharmacy, National University of Rwanda, Butare, Rwanda
    Ann Trop Paediatr 28:103-9. 2008
    b>Quinine sulphate (QS), like most other antimalarials, is in tablet form designed for adults. In children, treatment is based on breaking the tablets to adapt the dose to the child's bodyweight...
  49. ncbi Ethanol-associated olfactory stimuli reinstate ethanol-seeking behavior after extinction and modify extracellular dopamine levels in the nucleus accumbens
    S N Katner
    The Scripps Research Institute, Department of Neuropharmacology, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 23:1751-60. 1999
    ..The present study employed an operant response-reinstatement model to examine the effects of ethanol-associated environmental stimuli on alcohol-seeking behavior and extracellular dopamine (DA) levels in the nucleus accumbens (NAcc)...
  50. ncbi Comparison of oral artesunate and quinine plus tetracycline in acute uncomplicated falciparum malaria
    J Karbwang
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Bull World Health Organ 72:233-8. 1994
    ..We have carried out a comparative clinical trial of the standard regimen of quinine + tetracycline versus oral artesunate at a 700-mg total dose given over 5 days to patients with acute ..
  51. ncbi Mefloquine versus quinine plus sulphalene-pyrimethamine (metakelfin) for treatment of uncomplicated imported falciparum malaria acquired in Africa
    Alberto Matteelli
    Institute of Infectious and Tropical Diseases, University of Brescia, Brescia 25125, Italy
    Antimicrob Agents Chemother 49:663-7. 2005
    We conducted a multicenter, randomized, open-label trial to compare mefloquine with a 3-day quinine plus sulphalene-pyrimethamine (SP) regimen for the treatment of imported uncomplicated malaria acquired in Africa...
  52. ncbi Role of parabrachial nucleus in submandibular salivary secretion induced by bitter taste stimulation in rats
    R Matsuo
    Department of Oral Physiology, Okayama University Dental School, Japan
    Auton Neurosci 88:61-73. 2001
    When rats lick a bitter taste solution such as quinine-hydrochloride, they secrete profuse amounts of saliva. The salivation has a higher flow rate than that induced by other qualities of taste stimulation: sweet, salty, and sour...
  53. ncbi Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs
    Coy D Fitch
    Department of Internal Medicine, School of Medicine, Saint Louis University Health Sciences Center, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Life Sci 74:1957-72. 2004
    ..Treatment with quinoline-4-methanol drugs, such as quinine and mefloquine, also causes morphologic changes, but does not cause hemoglobin accumulation...
  54. ncbi Treatment of uncomplicated malaria in children in Guinea-Bissau with chloroquine, quinine, and sulfadoxine-pyrimethamine
    Poul Erik Kofoed
    Department of Paediatrics, Kolding Hospital, Denmark
    Trans R Soc Trop Med Hyg 96:304-9. 2002
    ..children with Plasmodium falciparum mono-infection were allocated at random to one of 4 treatments: 15 mg/kg quinine twice a day for 3 d (group 1); 10 mg/kg quinine twice a day for 3 d followed by a total dose of 25 mg chloroquine ..
  55. ncbi Quinine disposition in globally malnourished children with cerebral malaria
    E Pussard
    Institut National de la Sante et de la Recherche Medicale, Unité 13, CHU Bichat, Paris, France
    Clin Pharmacol Ther 65:500-10. 1999
    Both malnutrition and malaria affect drug disposition and are frequent among children in the tropics. We assessed their respective influence on quinine distribution.
  56. ncbi Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunate
    Wanna Chaijaroenkul
    Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Rangsit, Patumthani 12121, Thailand
    Acta Trop 113:190-4. 2010
    ..falciparum isolates to chloroquine (CQ), mefloquine (MQ), quinine (QN) and the artemisinin derivative - artesunate (AS). A total of 26 P...
  57. ncbi Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia
    A Ratcliff
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia
    Trans R Soc Trop Med Hyg 101:351-9. 2007
    ..vivax infections. Patients with P. falciparum failing therapy were re-treated with unsupervised quinine+/-doxycycline therapy and those with P. vivax with either unsupervised quinine+/-doxycycline or amodiaquine...
  58. ncbi Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial
    Jane Achan
    Makerere University School of Health Sciences, PO Box 7475, Kampala, Uganda
    BMJ 339:b2763. 2009
    To compare the effectiveness of oral quinine with that of artemether-lumefantrine in treating uncomplicated malaria in children.
  59. ncbi Pharmacokinetics of quinine and its metabolites in pregnant Sudanese women with uncomplicated Plasmodium falciparum malaria
    I I Abdelrahim
    Faculty of Medicine, University of Khartoum, Khartoum, Sudan
    J Clin Pharm Ther 32:15-9. 2007
    The study was conducted in New Halfa teaching hospital, eastern Sudan to investigate the pharmacokinetics of quinine in pregnant Sudanese women.
  60. ncbi Separation of Cinchona alkaloids on a novel strong cation-exchange-type chiral stationary phase-comparison with commercially available strong cation exchanger and reversed-phase packing materials
    Christian V Hoffmann
    Department of Analytical Chemistry and Food Chemistry, Christian Doppler Laboratory for Molecular Recognition Materials, University of Vienna, Wahringer Strasse 38, A 1090, Vienna, Austria
    Anal Bioanal Chem 393:1257-65. 2009
    ..chiral strong cation exchanger (cSCX) type stationary phase was investigated for the LC separation of a series of Cinchona alkaloids and synthetic derivatives thereof to test its usefulness as alternative methodology for the separation ..
  61. ncbi Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
    Jane Achan
    Department of Pediatrics and Child Health, Makerere University College of Health Sciences, P O Box 7475, Kampala, Uganda
    Malar J 10:144. 2011
    b>Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented...
  62. ncbi Variable inhibitory effect of different brands of commercial herbal supplements on human cytochrome P-450 CYP3A4
    Sompon Wanwimolruk
    School of Pharmacy, Loma Linda University, Loma Linda, CA 92350, USA
    Drug Metabol Drug Interact 24:17-35. 2009
    ..Aliquots of the extract were tested for their ability to inhibit the metabolism of the human CYP3A4 probe quinine, using an in vitro liver microsomal technique...
  63. ncbi Quinine sulphate pellets for flexible pediatric drug dosing: formulation development and evaluation of taste-masking efficiency using the electronic tongue
    P C Kayumba
    Department of Pharmacy, National University of Rwanda, Butare, Rwanda
    Eur J Pharm Biopharm 66:460-5. 2007
    The purpose of this study was to develop a taste-masked quinine sulphate dosage form as a flexible pediatric formulation tool...
  64. ncbi [A history of malaria in modern Korea 1876-1945]
    Insok Yeo
    Department of Medical History, Yonsei University, Seoul, Korea
    Uisahak 20:53-82. 2011
    ..Very effective anti-malarial drug quinine was imported and it made great contribution in treating malaria...
  65. ncbi Bifunctional catalysis by natural cinchona alkaloids: a mechanism explained
    Clotilde S Cucinotta
    Computational Science, Department of Chemistry and Applied Biosciences, ETH Zurich c o USI Campus, Via Giuseppe Buffi 13, 6900 Lugano, Switzerland
    Chemistry 15:7913-21. 2009
    ..b>Cinchona alkaloids such as quinine and quinidine, simple organic molecules generously provided by Nature, were the first ..
  66. ncbi Sweet and bitter taste of ethanol in C57BL/6J and DBA2/J mouse strains
    David A Blizard
    Center for Developmental and Health Genetics, The Pennsylvania State University, 201, Research Building D, University Park, PA 16802, USA
    Behav Genet 37:146-59. 2007
    ..conditioned taste aversion (CTA) to explore the sweet and bitter taste of ethanol and ability to detect sucrose, quinine and ethanol in C57BL/6J (B6) and DBA/2J (D2) mouse strains that are frequently used in alcohol research...
  67. ncbi Taste reactivity and its modulation by morphine and methamphetamine in C57BL/6 and DBA/2 mice
    Barbara Cagniard
    Molecular Neuropathology Group, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
    Physiol Behav 96:412-20. 2009
    ..In particular, compared to D2 mice, B6 mice avidly drink ethanol and sucrose solutions, but avoid quinine solutions...
  68. ncbi Chronic alcohol administration in the rat pup: effects upon later consumption of alcohol and other palatable solutions
    M F Lopez
    Instituto de Investigacion Medica, Mercedesy Martín Ferreyra, CONICET, Cordoba, Argentina
    Addict Biol 4:169-79. 1999
    ..consumption of an ethanol solution as well as upon intake of various non-ethanol solutions (water, sucrose, quinine or sucrose mixed with quinine)...
  69. ncbi Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptake
    Sandra C dos Santos
    Institute for Biotechnology and Bioengineering IBB, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal
    Antimicrob Agents Chemother 53:5213-23. 2009
    b>Quinine has been employed in the treatment of malaria for centuries and is still used against severe Plasmodium falciparum malaria. However, its interactions with the parasite remain poorly understood and subject to debate...
  70. ncbi Taste coding after selective inhibition by chlorhexidine
    Miao Fen Wang
    John B Pierce Laboratory, Yale University School of Medicine, New Haven, CT 06519, USA
    Chem Senses 34:653-66. 2009
    ..a bis-biguanide antiseptic, reversibly inhibits salty taste and tastes of a subset of bitter stimuli, including quinine hydrochloride. Identifications of salty (NaCl, "salt"), bitter (quinine...
  71. ncbi Diminished Plasmodium falciparum sensitivity to quinine exposure in vitro and in a sequential multi-drug regimen: A preliminary investigation in Guyana, South America
    Wallis Best Plummer
    Department of Pharmacy, Faculty of Health Sciences, University of Guyana, Georgetown, Guyana
    Int J Infect Dis 12:e27-31. 2008
    ..to investigate the response of uncomplicated falciparum infections to semi-supervised drug administration with quinine and two adjunctive schizontocidal drugs in infected patients in Guyana...
  72. ncbi Application of multivariate methods to the simultaneous Fourier Transform Infrared (FT-IR) spectrometric determination of stereo-isomers; quinine and quinidine
    Abdel Aziz Mohamed Wahbi
    Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt
    Chem Pharm Bull (Tokyo) 56:787-91. 2008
    The two stereo-isomers; quinine and quinidine have been determined in their mixtures in the IR region using chemometric multivariate methods, principal component regression (PCR) and partial least squares (PLS)...
  73. ncbi The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex
    John N Alumasa
    Department of Chemistry, Georgetown University, Washington, DC 20057, USA
    J Inorg Biochem 105:467-75. 2011
    ..Under biological conditions, chloroquine (CQ) appears to prefer to bind to ?-oxo dimeric heme, while quinine (QN) preferentially binds monomer...
  74. ncbi Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa
    Valérie Andriantsoanirina
    Institut Pasteur de Madagascar, Unité de Recherche sur le Paludisme, Antananarivo, Madagascar, France
    Am J Trop Med Hyg 82:782-7. 2010
    ..of polymorphisms in Plasmodium falciparum nhe-1 (Pfnhe-1, gene PF13_0019) with in vitro susceptibility to quinine, which was previously reported in a limited number of reference strains or culture-adapted isolates...
  75. ncbi Artemisinin derivatives versus quinine in treating severe malaria in children: a systematic review
    George PrayGod
    National Institute for Medical Research, Mwanza, Tanzania
    Malar J 7:210. 2008
    The efficacy of intravenous quinine, which is the mainstay for treating severe malaria in children, is decreasing in South East Asia and Africa. Artemisinin derivatives are a potential alternative to quinine...
  76. ncbi Ethanol, saccharin, and quinine: early ontogeny of taste responsiveness and intake
    Andrey P Kozlov
    Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York 13902 6000, USA
    Alcohol Clin Exp Res 32:294-305. 2008
    ..Therefore, the present study compared responsiveness to ethanol and solutions with bitter (quinine) and sweet (saccharin) taste in terms of intake and palatability across the first 2 weeks of postnatal life.
  77. ncbi Pilot feasibility study of an emergency paediatric kit for intra-rectal quinine administration used by the personnel of community-based health care units in Senegal
    Jean Louis A Ndiaye
    Service de Parasitologie, Faculte de Medecine, université Cheikh Anta Diop de Dakar, Senegal
    Malar J 6:152. 2007
    b>Quinine injection is the reference treatment for malaria when oral administration is impossible...
  78. ncbi In vitro monitoring of Plasmodium falciparum drug resistance in French Guiana: a synopsis of continuous assessment from 1994 to 2005
    Eric Legrand
    Reference Centre for Plasmodium Chemoresistance in French Guiana and West Indies CNRCP, Institut Pasteur de la Guyane, Cayenne, French Guiana
    Antimicrob Agents Chemother 52:288-98. 2008
    ..The quinine-doxycycline combination was introduced in 1995 as the first-line drug treatment against uncomplicated P...
  79. ncbi Determination of cinchona alkaloids by non-aqueous CE with MS detection
    Wolfgang Buchberger
    Institute of Analytical Chemistry, Johannes Kepler University, Linz, Austria
    Electrophoresis 31:1208-13. 2010
    Non-aqueous CZE was investigated for separation of cinchona alkaloids including diastereomeric pairs of analytes such as quinine/quinidine or cinchonine/cinchonidine...
  80. ncbi Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia
    Daniel W Bougie
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Blood 113:1105-11. 2009
    ..1 and 314.3, from a mouse immunized with purified human GPIIb/IIIa and quinine that recognize the N terminus of the GPIIb beta propeller domain only when soluble quinine is present...
  81. ncbi Riboflavin-binding protein is a novel bitter inhibitor
    Kenji Maehashi
    Department of Fermentation Science, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo, Japan
    Chem Senses 33:57-63. 2008
    ..RBP elicited broadly tuned inhibition of various bitter substances including quinine-HCl, naringin, theobromine, caffeine, glycyl-L-phenylalanine (Gly-Phe), and denatonium benzoate, whereas several ..
  82. ncbi Quinine carbamate chiral stationary phases: systematic optimization of steric selector-selectand binding increments and enantioselectivity by quantitative structure-enantioselectivity relationship studies
    Michael Lämmerhofer
    Christian Doppler Laboratory for Molecular Recognition Materials, Department of Analytical Chemistry, University of Vienna, Vienna, Austria
    J Sep Sci 29:1486-96. 2006
    A series of quinine carbamate-based chiral stationary phases (CSPs) differing solely in the carbamate residue have been devised and a congeneric set of N-3,5-dinitrobenzoyl (DNB) amino acids (AAs) was separated into enantiomers on these ..
  83. ncbi Activation by bitter substances of a cationic channel in membrane patches excised from the bullfrog taste receptor cell
    T Tsunenari
    Department of Physiology, Keio University School of Medicine, Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    J Physiol 519:397-404. 1999
    ..2. Application of a bitter-tasting substance, quinine or denatonium, induced channel openings under conditions in which none of the second messenger candidates or ..
  84. ncbi Quinine versus carbamoylated quinine-based chiral anion exchangers. A comparison regarding enantioselectivity for N-protected amino acids and other chiral acids
    A Mandl
    Institute of Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Austria
    J Chromatogr A 858:1-11. 1999
    First, a chiral stationary phase was prepared by immobilization of the naturally occurring alkaloid quinine onto a 3-mercaptopropyl-modified silica gel via a radical addition reaction and it was evaluated for direct HPLC ..
  85. ncbi Stability, compatibility and plasticizer extraction of quinine injection added to infusion solutions and stored in polyvinyl chloride (PVC) containers
    M A Faouzi
    Laboratoire de Pharmacologie, Pharmacocinetique et Pharmacie Clinique, Faculte des Sciences Pharmaceutiques et Biologiques, Lille, France
    J Pharm Biomed Anal 21:923-30. 1999
    The stability of quinine was determined in various diluents and in polyvinyl chloride (PVC) containers. The release of diethyhexyl phthalate (DEHP) from PVC bags into intravenous infusions of quinine was also measured...
  86. ncbi Further characterization of the quinine taste discrimination stimulus in rhesus monkeys: effects of inter-trial interval, number and distribution of test stimuli
    J A Vivian
    Department of Pharmacology, University of Michigan, Ann Arbor, USA
    Behav Pharmacol 10:313-8. 1999
    ..purpose of the current investigation was to characterize further the taste discriminative stimulus properties of quinine. Using a food-maintained two-choice (quinine and water) discrimination paradigm, the effects of varying inter-..
  87. ncbi [Tolerance of quinine administered as an intrarectal solution in children in French-speaking Africa]
    H Barennes
    Unité d Epidémiologie d Intervention, Centre Muraz, Bobo Dioulasso, Burkina Faso
    Med Trop (Mars) 59:383-8. 1999
    Pharmacokinetic studies have documented the efficacy of intrarectal quinine (IRQ) for treatment of childhood malaria...
  88. ncbi Effect of extracellular Ca2+ on the quinine-activated current of bullfrog taste receptor cells
    T Tsunenari
    Department of Physiology, Keio University School of Medicine, Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    J Physiol 530:235-41. 2001
    The bitter substance quinine activates a cation current from the frog taste receptor cell...
  89. ncbi Clinical trial of beta-arteether versus quinine for the treatment of cerebral malaria in children in Yaounde, Cameroon
    R Moyou-Somo
    Institute of Medical Research and Study of Medicinal Plants Medical Research Center, Yaounde, Cameroon, West Africa
    Am J Trop Med Hyg 64:229-32. 2001
    ..2 mg/kg on Day 0, followed by 1.6 mg/kg on Days 1 to 4) or intravenous (i.v.) quinine dihydrochloride (20 mg of the salt/kg, followed by 10 mg of the salt/kg every 8 hr up to Day 6)...
  90. ncbi Quinine blocks specific gap junction channel subtypes
    M Srinivas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 98:10942-7. 2001
    We demonstrate that the antimalarial drug quinine specifically reduces currents through gap junctions formed by some connexins (Cx) in transfected mammalian cells, but does not affect other gap junction types...
  91. ncbi Quinine for nocturnal leg cramps: a meta-analysis including unpublished data
    M Man-Son-Hing
    Department of Medicine, University of Ottawa, Ont, Canada
    J Gen Intern Med 13:600-6. 1998
    OBJECTIVE: With respect to the use of quinine for the treatment of nocturnal leg cramps, to determine whether the findings of a previously performed meta-analysis of published data are altered with the addition of unpublished data, and ..
  92. ncbi Response of uncomplicated falciparum malaria to oral chloroquine and quinine in Burundi highlands
    G Di Perri
    Istituto di Immunologia e Malattie Infettive, , Ospedale Civile Maggiore, Italy
    Acta Trop 70:25-33. 1998
    The in vivo response of falciparum malaria to oral chloroquine and quinine was evaluated in two identical hospital-based, comparative open trials carried out 2 years apart in the same seasonal period at a hospital located in the ..
  93. ncbi Pharmacological characterization of muscarinic receptor-activated cation channels in guinea-pig ileum
    S Chen
    Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 109:793-801. 1993
    ..2. Well-known K channel blockers, tetraethylammonium (TEA), 4-aminopyridine (4-AP), procaine and quinine as well as a Ca releasing agent, caffeine, all produced concentration-dependent inhibition of Icat with rapid ..
  94. ncbi Therapeutic effects of chloroquine in combination with quinine in uncomplicated falciparum malaria
    S Vanijanonta
    Hospital for Tropical Diseases, Faculty of Tropical Medicine, Bangkok, Thailand
    Ann Trop Med Parasitol 90:269-75. 1996
    The efficacy and toxicity of oral quinine combined with oral chloroquine were studied in 50 Thai men with uncomplicated falciparum malaria. All were treated for 7 days with quinine sulphate (10 mg salt/kg every 8 h)...
  95. ncbi Anticipatory contrast effect in rats: a new view with lick response analysis and the effect of dopamine blocking
    B H Chen
    Department of Psychology, National Chung Cheng University, Chia Yi, Taiwan, ROC
    Chin J Physiol 39:235-43. 1996
    ..008% quinine (A), 8% sucrose with 0.002% quinine (B), and 32% sucrose with 0.008% quinine (C)...
  96. ncbi Purification and characterization of two isoforms of isopentenyl-diphosphate isomerase from elicitor-treated Cinchona robusta cells
    A C Ramos-Valdivia
    Division of Pharmacognosy, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    Eur J Biochem 249:161-70. 1997
    In Cinchona robusta (Rubiaceae) cell suspension cultures, the activity of the enzyme isopentenyl-diphosphate isomerase (isopentenyl-POP isomerase) is transiently induced after addition of a homogenate of the phytopathogenic fungus ..
  97. ncbi Intramuscular artemether vs intravenous quinine: an open, randomized trial in Malawian children with cerebral malaria
    T E Taylor
    Wellcome Trust Centre, Queen Elizabeth Central Teaching Hospital, Blantyre, Malawi
    Trop Med Int Health 3:3-8. 1998
    OBJECTIVES: To compare artemether (by intramuscular injection) and quinine (by intravenous infusion) as treatments for cerebral malaria in African children...
  98. ncbi Salicylate and quinine selectively increase spontaneous firing rates in secondary auditory cortex
    J J Eggermont
    Department of Physiology and Biophysics, The University of Calgary, Alta, Canada
    Hear Res 117:149-60. 1998
    ..auditory field (AAF) and secondary auditory cortex (AII) in cats before and after application of salicylate or quinine. From 21 cats, in three cortical areas simultaneously, a total of 1533 multi-unit files were obtained...
  99. ncbi Effect of artemether on electrocardiogram in severe falciparum malaria
    J Karbwang
    Clinical Pharmacology Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 28:472-5. 1997
    ..intramuscular loading dose of 160 mg, followed by 80 mg daily for another 6 doses), in comparison with that of quinine (intravenous infusion of loading dose of 20 mg/kg, followed by 10 mg/kg q 8 hourly for 7 days), on the ..
  100. ncbi Randomized comparison of intramuscular artemether and intravenous quinine in adult, Melanesian patients with severe or complicated, Plasmodium falciparum malaria in Papua New Guinea
    R A Seaton
    Department of Clinical Sciences, University of Papua New Guinea, Port Moresby, Papua, New Guinea
    Ann Trop Med Parasitol 92:133-9. 1998
    ..2 mg/kg, followed by 1.6 mg/kg daily for 4 days) and intravenous quinine (a loading dose of 20 mg quinine dihydrochloride/kg, followed first by 10 mg/kg every 8 h, each injection taking ..

Research Grants89

  1. New Antimalarials from Plant-Pathogenic Fungi
    NP NANAYAKKARA; Fiscal Year: 2005
    ..Natural products isolated from higher plants, such as quinine and artemisinin, have provided effective drugs against malaria...
  2. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2004
    ..We will measure in vitro susceptibility to 4 important antimalarial compounds-mefloquine, quinine, artemisinin and chloroquine in malaria parasites obtained from a site on the Thai-Burmese border...
  3. MALARIA CHEMOTHERAPY AND CHEMOPROTECTION
    Gary Posner; Fiscal Year: 2000
    Among infectious diseases, malaria is common in many parts of the world. Standard alkaloids such as quinine and chloroquine are becoming less and less effective because malaria parasites are developing resistance to such drugs...
  4. Effects of expectation on gustatory cortical activity
    Alfredo Fontanini; Fiscal Year: 2009
    ..in which one tone cues the availability of a palatable taste (sucrose or NaCl) and the other a punishment (quinine) at a press of a lever, will reveal the effects of expectation of particular tastes having opposite affective ..
  5. Effects of expectation on gustatory cortical activity
    Alfredo Fontanini; Fiscal Year: 2010
    ..in which one tone cues the availability of a palatable taste (sucrose or NaCl) and the other a punishment (quinine) at a press of a lever, will reveal the effects of expectation of particular tastes having opposite affective ..
  6. Evolutionary Dissection of complex traits
    Stephen Wooding; Fiscal Year: 2007
    ..Many well-known bitter compounds such as quinine, nicotine, and caffeine, for example, are toxins produced naturally by plants...
  7. HIGH-THROUGHPUT SCEENS FOR ASSESSING TASTE SENSITIVITY
    JOHN GLENDINNING; Fiscal Year: 2001
    ..Because this screen will be conducted with an expansive array of concentrations of each taste stimulus (quinine, NaCl, and sucrose), it will be able to detect gross and subtle alterations in taste sensitivity in either ..
  8. ASYMMETRIC 1,2-ADDITIONS
    DAVID COLLUM; Fiscal Year: 2001
    ..While the highly selective additions to imines behave quite differently from the additions to ketones (requiring lithiated quinine or quinidine), the strategies and analytical methods used to study them will be similar.
  9. Combined Voltammetry/Electrophysiology in Behaving Rats
    Regina M Carelli; Fiscal Year: 2010
    ..aversive (quinine) tastant...
  10. Immune Dysregulation in HIT
    Gowthami Arepally; Fiscal Year: 2009
    ..disorder, its immunologic features bear little resemblance to other commonly encountered drug allergies, like quinine or penicillin...
  11. Immune Dysregulation in HIT
    Gowthami M Arepally; Fiscal Year: 2010
    ..disorder, its immunologic features bear little resemblance to other commonly encountered drug allergies, like quinine or penicillin...
  12. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2009
    ..aversive (quinine) tastant...
  13. MODULATION OF TASTE RESPONSES BY THE TRIGEMINAL SYSTEM
    SIDNEY SIMON; Fiscal Year: 2004
    ..That in turn will modulate the activity of CT neurons to lingual applications of NaCl, acid, sucrose, and quinine. This hypothesis will be tested by activating the TG nerve electrically and chemically (e.g...
  14. Temporal Coding in the Gustatory System of the Brain
    Patricia M Di Lorenzo; Fiscal Year: 2011
    ..pattern of electrical stimulation can mimic the perceptual properties and behavioral reactivity of either quinine or sucrose and b) construct a temporal sequence of electrical pulses which incorporates the critical features of ..
  15. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2007
    ..inhibition in peripheral mixture processing by testing the ability of hamsters to recognize components in sucrose-quinine, dulcin-quinine and sucrose-quinine-NaCI mixtures...
  16. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2007
    ..inhibition in peripheral mixture processing by testing the ability of hamsters to recognize components in sucrose-quinine, dulcin- quinine and sucrose-quinine-NaCI mixtures...
  17. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2009
    ..inhibition in peripheral mixture processing by testing the ability of hamsters to recognize components in sucrose-quinine, dulcin-quinine and sucrose-quinine-NaCI mixtures...
  18. PERIPHERAL GUSTATORY PROCESSING
    MARION ELIZABETH FRANK; Fiscal Year: 2010
    ..inhibition in peripheral mixture processing by testing the ability of hamsters to recognize components in sucrose-quinine, dulcin-quinine and sucrose-quinine-NaCI mixtures...
  19. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2003
    ..Hamster CT and GL nerve fibers respond to sucrose, sodium chloride, hydrochloric acid and quinine. HCl (QHCl) but greater than 75 percent of CT fibers are sucrose-best (S) or NaCl-best (N) and greater than 75 ..
  20. Asymmetric Reactions with Bifunctional Organocatalysis
    Li Deng; Fiscal Year: 2009
    ..the last several years our research program has made signiificant progress in the development and application of cinchona alkaloids as broadly useful chiral base/nucleophilic catalysts for asymmetric synthesis and in the elucidation of ..
  21. Asymmetric Reactions with Bifunctional Organocatalysis
    Li Deng; Fiscal Year: 2010
    ..the last several years our research program has made signiificant progress in the development and application of cinchona alkaloids as broadly useful chiral base/nucleophilic catalysts for asymmetric synthesis and in the elucidation of ..
  22. Asymmetric Reactions with Bifunctional Organocatalysis
    Li Deng; Fiscal Year: 2007
    ..the last several years our research program has made significant progress in the development and application of cinchona alkaloids as broadly useful chiral base/nucleophilic catalysts for asymmetric synthesis and in the elucidation of ..
  23. FUNCTIONAL ORGANIZATION OF PERIPHERAL GUSTATORY SYSTEM
    ALAN SPECTOR; Fiscal Year: 2006
    ..nucleus of the solitary tract [NST] (as assessed by Fos-like immunoreactivity) stimulated by oral application of quinine. The purpose of the research here is to extend these findings in new and important ways to help clarify the ..
  24. FUNCTIONAL ORGANIZATION OF PERIPHERAL GUSTATORY SYSTEM
    ALAN SPECTOR; Fiscal Year: 2007
    ..nucleus of the solitary tract [NST] (as assessed by Fos-like immunoreactivity) stimulated by oral application of quinine. The purpose of the research here is to extend these findings in new and important ways to help clarify the ..