Methanothermobacter thermautotrophicus str. Delta H

Summary

Alias: Methanobacterium thermoautotrophicum str. Delta H, Methanothermobacter thermautotrophicus str. deltaH, Methanobacterium thermoautotrophicum str. deltaH

Top Publications

  1. ncbi A recombinant exonuclease III homologue of the thermophilic archaeon Methanothermobacter thermautotrophicus
    Sven Pfeifer
    Institute of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig Biotechnological Biomedical Centre Leipzig, Bruderstrasse 34, 04103 Leipzig, Germany
    DNA Repair (Amst) 4:433-44. 2005
  2. pmc Crystal structure of a Ba(2+)-bound gating ring reveals elementary steps in RCK domain activation
    Frank J Smith
    Department of Biochemistry, Temple University School of Medicine, 3400 N Broad Street, Philadelphia, PA 19140, USA
    Structure 20:2038-47. 2012
  3. pmc Structure and activity of a novel archaeal β-CASP protein with N-terminal KH domains
    Ana P G Silva
    York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, United Kingdom
    Structure 19:622-32. 2011
  4. pmc Role of motif III in catalysis by acetyl-CoA synthetase
    Cheryl Ingram-Smith
    Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634 0318, USA
    Archaea 2012:509579. 2012
  5. ncbi Analysis of membrane stereochemistry with homology modeling of sn-glycerol-1-phosphate dehydrogenase
    Hiromi Daiyasu
    Department of Computational Biology, Biomolecular Engineering Research Institute, 6 2 3, Furuedai, Suita, Osaka 565 0874, Japan
    Protein Eng 15:987-95. 2002
  6. pmc The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
    Satwik Kamtekar
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520 8114, USA
    Proc Natl Acad Sci U S A 100:1673-8. 2003
  7. pmc Deep trefoil knot implicated in RNA binding found in an archaebacterial protein
    Thomas I Zarembinski
    Biosciences Division, Structural Biology Center, Argonne National Laboratory, Argonne, Illinois 60439, USA
    Proteins 50:177-83. 2003
  8. ncbi The open pore conformation of potassium channels
    Youxing Jiang
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:523-6. 2002
  9. ncbi Crystal structure and mechanism of a calcium-gated potassium channel
    Youxing Jiang
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:515-22. 2002
  10. ncbi Identification of a novel archaebacterial thioredoxin: determination of function through structure
    Sudeepa Bhattacharyya
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Biochemistry 41:4760-70. 2002

Research Grants

  1. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2003
  2. Archaeal gene recruitment by the Chlamydiales
    David Graham; Fiscal Year: 2007
  3. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2007
  4. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2006
  5. Biochemistry of lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2010

Scientific Experts

  • Yosuke Koga
  • Z Kelman
  • David E Graham
  • H H Saxild
  • A Wasserfallen
  • M Ibba
  • Jaume M Canaves
  • C Leong Ng
  • B Mukhopadhyay
  • Dinesh Christendat
  • Hiromi Daiyasu
  • Cheryl H Arrowsmith
  • R K Thauer
  • Adelinda Yee
  • Youxing Jiang
  • Emil F Pai
  • R Hedderich
  • Vivian Saridakis
  • W Grabarse
  • Angelica M Bello
  • S Shima
  • Masahiro Fujihashi
  • U Ermler
  • Cheryl Ingram-Smith
  • Frank J Smith
  • Ana P G Silva
  • Godwin Amegbey
  • Anselm Sauerwald
  • N Wu
  • Kristina Lakomek
  • David S Wishart
  • Dieter Soll
  • Krisztina Toth
  • A Hochheimer
  • Sudeepa Bhattacharyya
  • Naoya Shinzato
  • J NOLLING
  • J Chris Ellis
  • You Na Kang
  • Ewa Poduch
  • Olivier Julien
  • Sheng Ye
  • Lakshmi P Kotra
  • Liping Chen
  • John K Lee
  • Sven Pfeifer
  • A Dharamsi
  • Yen Ju Chen
  • A Yee
  • Jianbo Dong
  • Thomas Spreter
  • James W Brown
  • Pablo Gutierrez
  • Chang Hun Lee
  • Francisco J Blanco
  • M Goubeaud
  • Jin Won Jung
  • Weontae Lee
  • Amanda A Brindley
  • Satwik Kamtekar
  • Bin Wu
  • Godwin Y Amegbey
  • Cheryl Arrowsmith
  • Alexander Stojanowic
  • Thomas I Zarembinski
  • Cameron Mura
  • Aled Edwards
  • Xiao Tao
  • D Linder
  • J N Reeve
  • Aled M Edwards
  • Constantinos Stathopoulos
  • Bahram Habibi-Nazhad
  • Ning Wu
  • Jacob P Keller
  • Roderick MacKinnon
  • Thomas A Hall
  • Ivan Ahel
  • Martine Cadene
  • Alice Lee
  • Jiayun Chen
  • Brian T Chait
  • M Vaupel
  • Gino Cingolani
  • Jerry L Thurman
  • Brad S Rothberg
  • Victor P T Pau
  • Karen Zimowski
  • P Strop
  • C Mura

Detail Information

Publications96

  1. ncbi A recombinant exonuclease III homologue of the thermophilic archaeon Methanothermobacter thermautotrophicus
    Sven Pfeifer
    Institute of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig Biotechnological Biomedical Centre Leipzig, Bruderstrasse 34, 04103 Leipzig, Germany
    DNA Repair (Amst) 4:433-44. 2005
    ..Considering the high intracellular potassium ion concentration in M. thermautotrophicus, our results suggest that the characterized thermophilic enzyme acts as an AP endonuclease in vivo with similar activities as Ape1...
  2. pmc Crystal structure of a Ba(2+)-bound gating ring reveals elementary steps in RCK domain activation
    Frank J Smith
    Department of Biochemistry, Temple University School of Medicine, 3400 N Broad Street, Philadelphia, PA 19140, USA
    Structure 20:2038-47. 2012
    ..Our results suggest a working hypothesis for a sequence of ligand-dependent conformational changes that may underlie RCK domain activation and channel gating...
  3. pmc Structure and activity of a novel archaeal β-CASP protein with N-terminal KH domains
    Ana P G Silva
    York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, United Kingdom
    Structure 19:622-32. 2011
    ..We hypothesize that this nuclease degrades mRNAs of proteins targeted for degradation and so regulates archaeal RNA turnover, possibly in concert with the exosome...
  4. pmc Role of motif III in catalysis by acetyl-CoA synthetase
    Cheryl Ingram-Smith
    Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634 0318, USA
    Archaea 2012:509579. 2012
    ..Interactions between these Asp and ATP are observed in all structures available for members of the superfamily, consistent with a critical role in substrate binding and catalysis for this invariant residue...
  5. ncbi Analysis of membrane stereochemistry with homology modeling of sn-glycerol-1-phosphate dehydrogenase
    Hiromi Daiyasu
    Department of Computational Biology, Biomolecular Engineering Research Institute, 6 2 3, Furuedai, Suita, Osaka 565 0874, Japan
    Protein Eng 15:987-95. 2002
    ....
  6. pmc The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
    Satwik Kamtekar
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520 8114, USA
    Proc Natl Acad Sci U S A 100:1673-8. 2003
    ..jannaschii ProRS misacylates tRNA(Pro) with cysteine, and argue against the proposal that these archaeal ProRS enzymes possess the dual capacity to aminoacylate both tRNA(Pro) and tRNA(Cys) with their cognate amino acids...
  7. pmc Deep trefoil knot implicated in RNA binding found in an archaebacterial protein
    Thomas I Zarembinski
    Biosciences Division, Structural Biology Center, Argonne National Laboratory, Argonne, Illinois 60439, USA
    Proteins 50:177-83. 2003
  8. ncbi The open pore conformation of potassium channels
    Youxing Jiang
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:523-6. 2002
    ..The open conformation favours high conduction by compressing the membrane field to the selectivity filter, and also permits large organic cations and inactivation peptides to enter the pore from the intracellular solution...
  9. ncbi Crystal structure and mechanism of a calcium-gated potassium channel
    Youxing Jiang
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:515-22. 2002
    ..Eight RCK domains (regulators of K(+) conductance) form a gating ring at the intracellular membrane surface. The gating ring uses the free energy of Ca(2+) binding in a simple manner to perform mechanical work to open the pore...
  10. ncbi Identification of a novel archaebacterial thioredoxin: determination of function through structure
    Sudeepa Bhattacharyya
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Biochemistry 41:4760-70. 2002
    ..On the basis of the results presented here, we predict that these small proteins are all members of a new class of truncated thioredoxins...
  11. ncbi Mapping the active site-ligand interactions of orotidine 5'-monophosphate decarboxylase by crystallography
    Ning Wu
    Department of Biochemistry, Centres of Excellence, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Biochemistry 41:4002-11. 2002
    ..Consequently, orotidine 5'-monophosphate decarboxylases seem to require the presence of a negative charge at this position for catalysis as well as for correct and stable folding...
  12. ncbi On the mechanism of biological methane formation: structural evidence for conformational changes in methyl-coenzyme M reductase upon substrate binding
    W Grabarse
    Max Planck Institut fur Biophysik, Frankfurt, Germany
    J Mol Biol 309:315-30. 2001
    ..The three different enzymatically inactive enzyme states are discussed with respect to their enzymatically active precursors and with respect to the catalytic mechanism...
  13. pmc Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase
    N Wu
    Department of Biochemistry, Centres of Excellence, University of Toronto, 1 King s College Circle, Toronto, ON Canada M5S 1A8
    Proc Natl Acad Sci U S A 97:2017-22. 2000
    ..The computational results are consistent with a catalytic mechanism that is characterized by Jencks's Circe effect...
  14. pmc Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum
    A Yee
    Division of Molecular and Structural Biology, Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada
    Proc Natl Acad Sci U S A 97:6311-5. 2000
    ..The position and conservation of charged surface residues suggests possible modes of interaction with other proteins, as well as a rationale for the thermal stability of this protein...
  15. ncbi Structure of coenzyme F(420) dependent methylenetetrahydromethanopterin reductase from two methanogenic archaea
    S Shima
    Max Planck Institut fur terrestrische Mikrobiologie, Karl von Frisch Strasse, Marburg, 35043, Germany
    J Mol Biol 300:935-50. 2000
    ..However, Mer and MetF do not show sequence similarities although they bind related substrates and catalyze an analogous reaction...
  16. ncbi Purification, crystallization and preliminary X-ray study of orotidine 5'-monophosphate decarboxylase
    N Wu
    Department of Biochemistry, University of Toronto, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Acta Crystallogr D Biol Crystallogr 56:912-4. 2000
    ..0, b = 98.6, c = 73.3 A, gamma = 104.0 degrees ), with four molecules in the asymmetric unit; the crystals diffract to 1.5 A resolution...
  17. ncbi Rapid fold and structure determination of the archaeal translation elongation factor 1beta from Methanobacterium thermoautotrophicum
    G Kozlov
    McGill University, Department of Biochemistry, Montreal, PQ, Canada
    J Biomol NMR 17:187-94. 2000
    ..This novel feature was not observed previously and may serve a structural function related to protein stability or may play a functional role in archaeal protein translation...
  18. ncbi Domain-specific recruitment of amide amino acids for protein synthesis
    D L Tumbula
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    Nature 407:106-10. 2000
    ..Closer inspection of the two amidotransferases reveals that each of them recruited a metabolic enzyme to aid its function; this provides direct evidence for a relationship between amino-acid metabolism and protein biosynthesis...
  19. ncbi Structural proteomics of an archaeon
    D Christendat
    Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto 610 University Ave, Toronto, Ontario, Canada M5G 2M9
    Nat Struct Biol 7:903-9. 2000
    ..This demonstrates that structural proteomics is feasible and can play a central role in functional genomics...
  20. pmc The crystal structure of a heptameric archaeal Sm protein: Implications for the eukaryotic snRNP core
    C Mura
    University of California at Los Angeles Department of Energy Laboratory of Structural Biology and Molecular Medicine, 201 Boyer Hall Molecular Biology Institute, Box 951570, Los Angeles, CA 90095 1570, USA
    Proc Natl Acad Sci U S A 98:5532-7. 2001
    ..The pronounced electrostatic asymmetry of the SmAP surface imparts directionality to putative SmAP-RNA interactions...
  21. ncbi A story of chelatase evolution: identification and characterization of a small 13-15-kDa "ancestral" cobaltochelatase (CbiXS) in the archaea
    Amanda A Brindley
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biol Chem 278:22388-95. 2003
    ..A classification scheme for chelatases is proposed...
  22. ncbi Mutational, structural, and kinetic studies of the ATP-binding site of Methanobacterium thermoautotrophicum nicotinamide mononucleotide adenylyltransferase
    Vivian Saridakis
    Molecular and Structural Biology, Ontario Cancer Institute, University Health Network, and the Department of Medical Biophysics, University of Toronto, Ontario, Canada
    J Biol Chem 278:34356-63. 2003
    ..3%, respectively, of WT NMNATase activity indicating that His-19 is a key catalytic group. Surprisingly, this H19A mutant displayed a novel and distinct mode of NAD+ binding when co-crystallized in the presence of NAD+ and SO42-...
  23. ncbi Structural and functional characterization of a thioredoxin-like protein (Mt0807) from Methanobacterium thermoautotrophicum
    Godwin Y Amegbey
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada T6G 2N8
    Biochemistry 42:8001-10. 2003
    ..thermoautotrophicum, while Mt0895 plays a minor or supportive role. We also suggest that these two molecules (Mt0807 and Mt0895) may represent a group of ancient proteins that were ancestral to both thioredoxins and glutaredoxins...
  24. doi Crystal structure analysis of DNA uridine endonuclease Mth212 bound to DNA
    Kristina Lakomek
    Department of Molecular Structural Biology, Institute of Microbiology and Genetics, Georg August University Gottingen, Justus von Liebig Weg 11, D 37077 Gottingen, Germany
    J Mol Biol 399:604-17. 2010
    ..In addition, Ser171, Asn153, and Lys125 in the substrate binding pocket appear to have important functions in the discrimination of aberrant uridine against naturally occurring thymidine and cytosine residues in double-stranded DNA...
  25. pmc An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms
    Krisztina Toth
    Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260 3000, USA
    Biochemistry 48:8006-13. 2009
    ....
  26. pmc Conformational flexibility and molecular interactions of an archaeal homologue of the Shwachman-Bodian-Diamond syndrome protein
    C Leong Ng
    York Structural Biology Laboratory, Chemistry Department, University of York, York, YO10 5YW, UK
    BMC Struct Biol 9:32. 2009
    ..Although genomic and biophysical studies have suggested involvement of this protein in RNA metabolism and in ribosome biogenesis, its interacting partners remain largely unknown...
  27. pmc Specific DNA binding of a potential transcriptional regulator, inosine 5'-monophosphate dehydrogenase-related protein VII, to the promoter region of a methyl coenzyme m reductase I-encoding operon retrieved from Methanothermobacter thermautotrophicus stra
    Naoya Shinzato
    Center of Molecular Biosciences, University of the Ryukyus, Nishihara cho, Okinawa 903 0213, Japan
    Appl Environ Microbiol 74:6239-47. 2008
    ..The results presented here suggest that IMPDH VII encoded by MTH126 is a plausible candidate for the transcriptional regulator of the mcr operon in this methanogen...
  28. pmc Methanogens with pseudomurein use diaminopimelate aminotransferase in lysine biosynthesis
    David E Graham
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712 0165, USA
    FEBS Lett 582:1369-74. 2008
    ..In contrast marine methanogens from the Methanococcales, which lack pseudomurein, appear to use a different diaminopimelate pathway for lysine biosynthesis...
  29. ncbi Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels
    Sheng Ye
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 126:1161-73. 2006
    ..Our findings, along with the previously determined open MthK structure, allow us to elucidate the ligand gating mechanism of RCK-regulated K(+) channels...
  30. pmc Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A
    John K Lee
    Macromolecular Structure Group, Department of Biochemistry and Biophysics, University of California, S 412C Genentech Hall, 600 16th Street, San Francisco, CA 94143 2240, USA
    Proc Natl Acad Sci U S A 102:18932-7. 2005
    ..As a result of this and other side-chain substituents in the walls of the channel, the channel is intermediate in size and exhibits differentially tuned electrostatics when compared with the other subfamilies...
  31. ncbi Structures of the MthK RCK domain and the effect of Ca2+ on gating ring stability
    Jianbo Dong
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 280:41716-24. 2005
    ..Additionally, our stability studies indicated that Ca2+ binding stabilizes the RCK domains in this octameric state...
  32. ncbi Solution Structure of MTH0776 from Methanobacterium thermoautotrophicum
    Godwin Amegbey
    Department of Computing Science and Biological Sciences, University of Alberta, Edmonton, Alberta, Canada, T6G 2E8
    J Biomol NMR 33:51-6. 2005
  33. ncbi Structural polymorphism of Methanothermobacter thermautotrophicus MCM
    Yen Ju Chen
    Department of Biochemistry and Molecular Genetics, Box 800733, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Mol Biol 346:389-94. 2005
    ..This offers new insight into the conformational dynamics of MCM and the phosphorylation-bypass phenotype in yeast...
  34. ncbi The crystal structure of archaeal nascent polypeptide-associated complex (NAC) reveals a unique fold and the presence of a ubiquitin-associated domain
    Thomas Spreter
    Institute for Chemistry Crystallography, Free University of Berlin, Takustrasse 6, D 14195 Berlin, Germany
    J Biol Chem 280:15849-54. 2005
    ..Based on the presented structure we propose a model for the eukaryotic heterodimeric NAC domain...
  35. pmc Solution structure of the hypothetical protein Mth677 from Methanobacterium thermoautotrophicum: a novel alpha+beta fold
    Francisco J Blanco
    NMR Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Protein Sci 13:1458-65. 2004
    ..coli...
  36. pmc Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum
    Chang Hun Lee
    Department of Biochemistry, College of Science, Yonsei University, 134 Seodaemoon Gu, Shinchondong, Seoul, Korea 120 749
    Protein Sci 13:1148-54. 2004
    ..Therefore, we propose that the MTH1880 protein contains a novel motif for calcium-specific binding, and may function as a calcium buffering protein...
  37. ncbi Transfer of pro-R hydrogen from NADH to dihydroxyacetonephosphate by sn-glycerol-1-phosphate dehydrogenase from the archaeon Methanothermobacter thermautotrophicus
    Yosuke Koga
    Department of Chemistry, University of Occupational and Environmental Health, Kitakyushu, Japan
    Biosci Biotechnol Biochem 67:1605-8. 2003
    ..These results confirmed a prediction of the tertiary structure of sn-glycerol-1-phosphate dehydrogenase by homology modeling...
  38. ncbi Crystal structures of MTH1187 and its yeast ortholog YBL001c
    Xiao Tao
    Department of Biological Sciences, Northeast Structural Genomics Consortium, Columbia University, New York, New York 10027, USA
    Proteins 52:478-80. 2003
  39. ncbi Physiological role of the F420-non-reducing hydrogenase (Mvh) from Methanothermobacter marburgensis
    Alexander Stojanowic
    Max Planck Institut fur terrestrische Mikrobiologie, Karl von Frisch Strasse, 35043, Marburg, Germany
    Arch Microbiol 180:194-203. 2003
    ....
  40. ncbi The biosynthesis of methylated amino acids in the active site region of methyl-coenzyme M reductase
    T Selmer
    Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat, D 35032 Marburg, Germany
    J Biol Chem 275:3755-60. 2000
    ..A mechanism for the methylation of glutamine at C-2 and of arginine at C-5 is discussed...
  41. ncbi Phenylalanyl-tRNA synthetase from the archaeon Methanobacterium thermoautotrophicum is an (alphabeta)2 heterotetrameric protein
    R Das
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114 USA
    Biochimie 81:1037-9. 1999
    ..Two ORFs with similarity to non-archaeal PheRSs alpha-subunits had previously been found in the genome sequence, but these results show that only one of them, MT742, is part of the active PheRS...
  42. ncbi Methanobacterium thermoautotrophicum encodes two multisubunit membrane-bound [NiFe] hydrogenases. Transcription of the operons and sequence analysis of the deduced proteins
    A Tersteegen
    Max Planck Institut für Mikrobiologie, Marburg, Germany
    Eur J Biochem 264:930-43. 1999
    ..A function of these putative membrane-bound [NiFe] hydrogenases as proton pumps involved in endergonic reactions, such as the synthesis of formylmethanofuran from CO2, H2 and methanofuran, is discussed...
  43. ncbi Isoleucyl-tRNA synthetase of Methanobacterium thermoautotrophicum Marburg. Cloning of the gene, nucleotide sequence, and localization of a base change conferring resistance to pseudomonic acid
    U Jenal
    Mikrobiologisches Institut, Eidgenossische Technische Hochschule, Zurich, Switzerland
    J Biol Chem 266:10570-7. 1991
    ..Both the mutant and the wild-type ileS gene were expressed in E. coli, and their products displayed the expected difference in sensitivity toward pseudomonic acid...
  44. pmc Relatedness of archaebacterial RNA polymerase core subunits to their eubacterial and eukaryotic equivalents
    B Berghöfer
    Department of Biology, Philipps University, Marburg, FRG
    Nucleic Acids Res 16:8113-28. 1988
    ..Putative functional domains were identified in two of the subunits of the archaebacterial enzyme...
  45. ncbi The tungsten formylmethanofuran dehydrogenase from Methanobacterium thermoautotrophicum contains sequence motifs characteristic for enzymes containing molybdopterin dinucleotide
    A Hochheimer
    Max Planck Institut fur terrestrische Mikrobiologie, Philipps Universitat, Marburg, Germany
    Eur J Biochem 234:910-20. 1995
    ..The fwd operon was found to be located in a region of the M. thermoautotrophicum genome encoding molybdenum enzymes and proteins involved in molybdopterin biosynthesis...
  46. pmc Cloning, sequencing, and growth phase-dependent transcription of the coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin reductase-encoding genes from Methanobacterium thermoautotrophicum delta H and Methanopyrus kandleri
    J NOLLING
    Department of Microbiology, Ohio State University, Columbus 43210, USA
    J Bacteriol 177:7238-44. 1995
    ....
  47. pmc A hydrogenase-linked gene in Methanobacterium thermoautotrophicum strain delta H encodes a polyferredoxin
    J N Reeve
    Department of Microbiology, Ohio State University, Columbus 43210
    Proc Natl Acad Sci U S A 86:3031-5. 1989
    ..The product of the mvhB gene is predicted to contain six tandomly repeated bacterial-ferredoxin-like domains and, therefore, is predicted to be a polyferredoxin that could contain as many as 48 iron atoms in 12 Fe4S4 clusters...
  48. ncbi Two genetically distinct methyl-coenzyme M reductases in Methanobacterium thermoautotrophicum strain Marburg and delta H
    S Rospert
    Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat Marburg, Federal Republic of Germany
    Eur J Biochem 194:871-7. 1990
    ..When the cultures were supplied with sufficient H2 and and CO2 and the cells grew exponentially, essentially only MCR II was found. When growth was limited by the gas supply, MCR I predominated...
  49. pmc Growth phase-dependent transcription of the genes that encode the two methyl coenzyme M reductase isoenzymes and N5-methyltetrahydromethanopterin:coenzyme M methyltransferase in Methanobacterium thermoautotrophicum delta H
    T D Pihl
    Department of Microbiology, Ohio State University, Columbus 43210
    J Bacteriol 176:6384-91. 1994
    ....
  50. pmc Transcription of the ileS operon in the archaeon Methanobacterium thermoautotrophicum Marburg
    U Jenal
    Mikrobiologisches Institut, Swiss Federal Institute of Technology, ETH Zentrum, Zurich
    J Bacteriol 175:5945-52. 1993
    ..Extensive decay of the orf401-ileS-purL message was observed. Degradation occurred, presumably by endonucleolytic cleavage, within the orf401 region...
  51. ncbi The energy conserving N5-methyltetrahydromethanopterin:coenzyme M methyltransferase complex from Methanobacterium thermoautotrophicum is composed of eight different subunits
    U Harms
    Max Planck Institut fur terrestrische Mikrobiologie, Philipps Universitat, Marburg, Germany
    Eur J Biochem 228:640-8. 1995
    ..The mtr operon was found to be located between the methyl-coenzyme M reductase I operon (mcr) and a downstream open reading frame predicted to encode a Na+/Ca2+, K+ exchanger...
  52. ncbi Cloning, sequencing, and transcriptional analysis of the coenzyme F420-dependent methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase gene from Methanobacterium thermoautotrophicum strain Marburg and functional expression in Escherichia coli
    B Mukhopadhyay
    Department of Microbiology, University of Iowa, Iowa City 52242
    J Biol Chem 270:2827-32. 1995
    ..The mtd coding sequence was followed by several poly(dT) sequences and an inverted repeat that could be transcription termination signals...
  53. ncbi The heterodisulfide reductase from Methanobacterium thermoautotrophicum contains sequence motifs characteristic of pyridine-nucleotide-dependent thioredoxin reductases
    R Hedderich
    Max Planck Institut für terrestrische Mikrobiologie und Laboratorium für Mikrobiologie des Fachbereichs Biologie, Philipps Universitat Marburg, Germany
    Eur J Biochem 225:253-61. 1994
    ..46 kDa) did not show sequence similarity to other known proteins, but appears to possess a C-terminal hydrophobic alpha-helix that might function as a membrane anchor. Although hdrB and hdrC are juxtaposed, these genes are not near hdrA...
  54. ncbi Primary structure of cyclohydrolase (Mch) from Methanobacterium thermoautotrophicum (strain Marburg) and functional expression of the mch gene in Escherichia coli
    M Vaupel
    Max Planck Institut fur terrestrische Mikrobiologie, Marburg, Germany
    Eur J Biochem 236:294-300. 1996
    ..The mch gene was overexpressed in Escherichia coli yielding an active enzyme of 37 kDa with a specific activity of 30 U/mg cell extract protein...
  55. ncbi The hemA gene encoding glutamyl-tRNA reductase from the archaeon Methanobacterium thermoautotrophicum strain Marburg
    C Hungerer
    Laboratorium für Mikrobiologie des Fachbereich Biologie der Philipps Universität, Marburg, Germany
    Bioorg Med Chem 4:1089-95. 1996
    ..0. The reductase utilized preferentially NADPH for the reduction of the activated carboxyl group. The presence of ATP and GTP showed no obvious influence on catalysis...
  56. ncbi H2-forming methylenetetrahydromethanopterin dehydrogenase, a novel type of hydrogenase without iron-sulfur clusters in methanogenic archaea
    C Zirngibl
    Laboratorium für Mikrobiologie des Fachbereichs Biologie, Philipps Universitat Marburg, Federal Republic of Germany
    Eur J Biochem 208:511-20. 1992
    ..thermoautotrophicum with respect both to molecular and catalytic properties...
  57. ncbi The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei and Methanobacterium thermoautotrophicum: induction of the molybdenum isoenzyme by molybdate and constitutive synthesis of the tungsten isoenzyme
    A Hochheimer
    Max Planck Institut fur terrestrische Mikrobiologie, Fachbereich Biologie, Philipps Universitat, Marburg, Germany
    Arch Microbiol 170:389-93. 1998
    ..In both organisms, the tungsten isoenzyme was found to be constitutively transcribed, whereas the transcription of the molybdenum operon was induced by molybdate. Induction by molybdate was not significantly affected by tungstate...
  58. ncbi A family of flavoproteins in the domains Archaea and Bacteria
    A Wasserfallen
    Mikrobiologisches Institut, Eidgenossische Technische Hochschule, Zurich, Switzerland
    Eur J Biochem 254:325-32. 1998
    ..gigas hemoflavoprotein [Gomes, C. M., Silva, G., Oliveira, S., LeGall, J., Liu, M.-Y., Xavier, A. V., Rodrigues-Pousada, C. & Teixeira, M. (1997) J. Biol. Chem. 272, 22502-22508], is discussed...
  59. ncbi The energy conserving methyltetrahydromethanopterin:coenzyme M methyltransferase complex from methanogenic archaea: function of the subunit MtrH
    B Hippler
    Max Planck Institut für terrestrische Mikrobiologie and Laboratorium für Mikrobiologie des Fachbereichs Biologie der Philipps Universität, Marburg, Germany
    FEBS Lett 449:165-8. 1999
    ..Sequence comparison revealed similarity of MtrH with MetH from Escherichia coli and AcsE from Clostridium thermoaceticum: both enzymes exhibit methyltetrahydrofolate:cob(I)alamin methyltransferase activity...
  60. ncbi Purification, regulation, and molecular and biochemical characterization of pyruvate carboxylase from Methanobacterium thermoautotrophicum strain deltaH
    B Mukhopadhyay
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 273:5155-66. 1998
    ..thermoautotrophicum strain DeltaH (Kenealy, W. R., and Zeikus, J. G. (1982) FEMS Microbiol. Lett. 14, 7-10) raise several questions for future investigations...
  61. ncbi Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation
    U Ermler
    Max Planck Institut fur Biophysik, Heinrich Hoffmann Strabetae 7, 60528 Frankfurt, Germany
    Science 278:1457-62. 1997
    ..Together with a second structurally characterized enzyme state (MCRsilent) containing the heterodisulfide of coenzymes M and B, a reaction mechanism is proposed that uses a radical intermediate and a nickel organic compound...
  62. ncbi Properties of H. volcanii tRNA intron endonuclease reveal a relationship between the archaeal and eucaryal tRNA intron processing systems
    K Kleman-Leyer
    Department of Microbiology, The Ohio State University, Columbus 43210, USA
    Cell 89:839-47. 1997
    ..These results provide evidence that the archaeal and eucaryal tRNA intron processing systems are related and suggest a common origin for tRNA introns in these organisms...
  63. pmc Tryptophan gene cluster of Methanobacterium thermoautotrophicum Marburg: molecular cloning and nucleotide sequence of a putative trpEGCFBAD operon
    L Meile
    Mikrobiologisches Institut, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Bacteriol 173:5017-23. 1991
    ..With the exception of TrpB, the beta subunit of tryptophan synthase, tryptophan was absent from all Trp polypeptides...
  64. ncbi Sequence homologies in the N-terminal region of the ribosomal 'A' proteins from Methanobacterium Thermoautotrophicum and Halobacterium cutirubrum
    A T Matheson
    Biochim Biophys Acta 626:162-9. 1980
    ..The sequence data from the 'A' proteins also indicate that, phylogenetically, the archaebacteria are much closer to the cytoplasmic components of eucaryotes than they are to the eubacteria (or 'true bacteria')...
  65. ncbi The molybdenum formylmethanofuran dehydrogenase operon and the tungsten formylmethanofuran dehydrogenase operon from Methanobacterium thermoautotrophicum. Structures and transcriptional regulation
    A Hochheimer
    Max Planck Institut fur terrestrische Mikrobiologie, Philipps Universitat Marburg, Germany
    Eur J Biochem 242:156-62. 1996
    ..thermo-autotrophicum revealed that the fwdHFGDACB gene cluster is transcribed in the presence of either molybdate or tungstate in the growth medium whereas the fmdECB gene cluster was only transcribed when molybdate was present...
  66. ncbi MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like repeats
    Olivier Julien
    Département de biochimie et de microbiologie and CREFSIP, Universite Laval, 3255 pav Marchand, Quebec, G1K 7P4, Canada
    J Biomol NMR 35:149-54. 2006
    ..Harrison, D., Hoang, L., Keagle, P., Lumm, W., Pothier, B., Qiu, D., Spadafora, R., Vicaire, R., Wang, Y., Wierzbowski, J., Gibson, R., Jiwani, N., Caruso, A., Bush, D., Reeve, J. N. et al. (1997) J. Bacteriol., 179, 7135-7155]...
  67. ncbi An unprecedented twist to ODCase catalytic activity
    Masahiro Fujihashi
    Molecular Design and Information Technology Center, Leslie Dan Faculty of Pharmacy, Toronto, ON M5S 2S2 Canada
    J Am Chem Soc 127:15048-50. 2005
    ..This potential of ODCase is very useful in the design of novel inhibitors...
  68. ncbi Purification and properties of N5, N10-methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum (strain Marburg)
    K Ma
    Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat, Marburg, Federal Republic of Germany
    Eur J Biochem 191:187-93. 1990
    ..3 mM and 3 microM, respectively. Vmax was 6000 mumol.min-1.mg protein-1 (kcat = 3600 s-1). The CH2 = H4MPT reductase was stable in the presence of air; at 4 C less than 10% activity was lost within 24 h...
  69. ncbi Sequence divergence of an archaebacterial gene cloned from a mesophilic and a thermophilic methanogen
    P T Hamilton
    J Mol Evol 22:351-60. 1985
    ..Although the two purE-complementing genes are apparently derived from a common ancestor, only the gene from M. smithii maintains a codon usage that conforms to the RNY rule...
  70. pmc Solution structure of ribosomal protein S28E from Methanobacterium thermoautotrophicum
    Bin Wu
    Northeast Structural Genomics Consortium, Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    Protein Sci 12:2831-7. 2003
    ..A broad positively charged surface extending over one side of the beta-barrel and into the flexible C terminus may present a putative binding site for RNA...
  71. ncbi Unique characteristics of superoxide dismutase of a strictly anaerobic archaebacterium Methanobacterium thermoautotrophicum
    M Takao
    Department of Biosciences, School of Hygienic Sciences, Kitasato University, Sagamihara, Japan
    J Biol Chem 266:14151-4. 1991
    ..Moreover, M. thermoautotrophicum SOD is resistant to azide and hydrogen peroxide as MnSODs are, suggesting that its evolution is distinct from known eubacterial FeSODs...
  72. ncbi Characterization of a superoxide dismutase gene from the archaebacterium Methanobacterium thermoautotrophicum
    M Takao
    Department of Bioscience, School of Hygienic Science, Kitasato University, Sagamihara, Japan
    Arch Biochem Biophys 283:210-6. 1990
    ..Between a putative promoter and the start codon there is an inverted repeat sequence which is also found in the counterpart of Halobacterium halobium...
  73. ncbi Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H
    L A Alex
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Biochemistry 29:7237-44. 1990
    ..The amino acid sequences of the subunits of the FRH are compared with those of other Ni-containing hydrogenases, including the methyl viologen reducing hydrogenase (MVH) of M. thermoautotrophicum delta H...
  74. ncbi Is Alba an RNase P subunit?
    J Chris Ellis
    Laboratory of Signal Transduction, NIEHS, Research Triangle Park, North Carolina, USA
    RNA Biol 4:169-72. 2007
    ..In addition, the presence of Mth1483p did not enhance the activity of RNase P holoenzyme reconstituted from recombinant subunits. In conclusion, we find no evidence that Alba is an RNase P subunit...
  75. pmc A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase
    You Na Kang
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 46:5050-62. 2007
    ....
  76. ncbi A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity
    Angelica M Bello
    Center for Molecular Design and Preformulations, Toronto General Research Institute, Toronto General Hospital, Toronto, ON M5G 2C4 Canada
    J Med Chem 50:915-21. 2007
    ..2 +/- 0.7 microM against P. falciparum ItG and 3D7 isolates, respectively. 6-Iodouridine 5'-monophosphate is a novel covalent inhibitor of ODCase, and its nucleoside analogue paves the way to a new class of inhibitors against malaria...
  77. ncbi Purification and properties of 5,10-methylenetetrahydromethanopterin reductase, a coenzyme F420-dependent enzyme, from Methanobacterium thermoautotrophicum strain delta H
    B W Te Brommelstroet
    Department of Microbiology, University of Nijmegen, The Netherlands
    J Biol Chem 265:1852-7. 1990
    ....
  78. ncbi RNA-dependent cysteine biosynthesis in archaea
    Anselm Sauerwald
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    Science 307:1969-72. 2005
    ....
  79. ncbi 8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization
    J A Fox
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139
    Biochemistry 26:4219-27. 1987
    ..There is iron associated with the alpha-subunit, but placement of the nickel and FAD has not been established...
  80. pmc Sequence divergence of seryl-tRNA synthetases in archaea
    H S Kim
    Department of Molecular Biophysics and Biochemistry, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520 8114, USA
    J Bacteriol 180:6446-9. 1998
    ..Gel shift experiments showed that M. thermoautotrophicum SerRS did not mischarge tRNACys with serine. This indicates that Cys-tRNACys is formed by direct acylation in these organisms...
  81. ncbi Crystal structure of the "cab"-type beta class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum
    P Strop
    Biochemistry Option, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 276:10299-305. 2001
    ..The structure reveals a Hepes buffer molecule bound 8 A away from the active site zinc, which suggests a possible proton transfer pathway from the active site to the solvent...
  82. pmc Growth- and substrate-dependent transcription of the formate dehydrogenase (fdhCAB) operon in Methanobacterium thermoformicicum Z-245
    J NOLLING
    Department of Microbiology, The Ohio State University, Columbus 43210, USA
    J Bacteriol 179:899-908. 1997
    ..Sequencing revealed the presence of very similar genes except that the genome of M. thermoautotrophicum, a methanogen incapable of growth on formate, lacked the fdhCAB operon...
  83. pmc Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins
    Thomas A Hall
    Department of Microbiology, North Carolina State University, Raleigh 27695 7615, USA
    RNA 8:296-306. 2002
    ..RNase P in Archaea is therefore composed of an RNA subunit similar to bacterial RNase P RNA and multiple protein subunits similar to those in the eukaryotic nucleus...
  84. ncbi Crystal structure of Methanobacterium thermoautotrophicum conserved protein MTH1020 reveals an NTN-hydrolase fold
    Vivian Saridakis
    Division of Molecular and Structural Biology, Ontario Cancer Institute, Toronto, Ontario, Canada
    Proteins 48:141-3. 2002
  85. ncbi Cysteine activation is an inherent in vitro property of prolyl-tRNA synthetases
    Ivan Ahel
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    J Biol Chem 277:34743-8. 2002
    ..Therefore, ProRS exhibits a natural level of mischarging that is to date unequalled among the aminoacyl-tRNA synthetases...
  86. ncbi The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyltransferase
    Jacob P Keller
    Department of Biological Sciences, 702A Fairchild Center, MC2434, Columbia University, New York, NY 10027, USA
    Structure 10:1475-87. 2002
    ..Therefore, MT0146/CbiT probably functions as a precorrin methyltransferase and represents the first enzyme identified with this activity that does not have the canonical precorrin methyltransferase fold...
  87. ncbi Purification and properties of N5-methyltetrahydromethanopterin:coenzyme M methyltransferase from Methanobacterium thermoautotrophicum
    P Gartner
    Laboratorium für Mikrobiologie des Fachbereichs Biologie, Philipps Universitat Marburg, Germany
    Eur J Biochem 213:537-45. 1993
    ..The apparent Km for N5-methyltetrahydromethanopterin was 260 microM and that for coenzyme M was 60 microM. The preparation was absolutely dependent on the presence of Ti(III) for activity. ATP enhanced the activity 1.5-2-fold...
  88. pmc The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs)
    Cameron Mura
    Howard Hughes Medical Institute, Molecular Biology Institute, Los Angeles, California 90095 1570, USA
    Protein Sci 12:832-47. 2003
    ..Finally, we found that both Pae and Mth SmAP1 gel-shift negatively supercoiled DNA. These results distinguish SmAPs from eukaryotic Sm proteins and suggest that SmAPs have a generic single-stranded nucleic acid-binding activity...
  89. ncbi Cloning, sequencing and immunological characterization of the corrinoid-containing subunit of the N5-methyltetrahydromethanopterin: coenzyme-M methyltransferase from Methanobacterium thermoautotrophicum
    E Stupperich
    Institut fur Mikrobiologie, Gottingen, Germany
    Eur J Biochem 217:115-21. 1993
    ..The N-terminal sequences of mtrC and mtrD are identical with two peptides of the N5-methyltetrahydromethanopterin:coenzyme-M methyltransferase complex from Methanobacterium, indicating that the mtr genes encode this membrane protein...
  90. ncbi Aspartate aminotransferase from a thermophilic formate-utilizing methanogen, Methanobacterium thermoformicicum strain SF-4: relation to serine and phosphoserine aminotransferases, but not to the aspartate aminotransferase family
    T Tanaka
    Department of Biology, Faculty of Science, Osaka City University
    J Biochem 115:309-17. 1994
    ..K., Hale, T.I., & Christen, P. (1993) Eur. J. Biochem. 214, 549-561], but not to subgroup I, in which all the AspATs known so far are included...
  91. ncbi H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties
    E Setzke
    Max Planck Institut für Terrestrsche Mikrobiologie, Marburg, Germany
    Eur J Biochem 220:139-48. 1994
    ..The stimulatory effects of potassium phosphate, a membrane component, uracil derivatives and coenzyme F430 on the H2:heterodisulfide-oxidoreductase activity of the purified complex are described...
  92. pmc Methyl viologen hydrogenase II, a new member of the hydrogenase family from Methanobacterium thermoautotrophicum delta H
    G J Woo
    Department of Microbiology, University of Illinois, Urbana 61801
    J Bacteriol 175:5970-7. 1993
    ..Both hydrogenases were shown to be stable for over 8 days at --20 degrees C under anaerobic conditions. When exposed to air, 90% of MVH I activity was lost within 2 min; however, MVH II lost only 50% of its activity in 3 h...
  93. pmc Structure of the archaeal translation initiation factor aIF2 beta from Methanobacterium thermoautotrophicum: implications for translation initiation
    Pablo Gutierrez
    McGill University, Department of Biochemistry, McIntyre Medical Science Building, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Protein Sci 13:659-67. 2004
    ..Based on structural similarity and biochemical data, a role for the different secondary structure elements is suggested...
  94. ncbi Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin reductase (Mer) from Methanobacterium thermoautotrophicum strain Marburg. Cloning, sequencing, transcriptional analysis, and functional expression in Escherichia coli of the mer gene
    M Vaupel
    Max Planck Institut fur terrestrische Mikrobiologie, Philipps Universitat Marburg, Germany
    Eur J Biochem 231:773-8. 1995
    ..thermoautotrophicum. Sequence comparisons revealed similarities between the F420-dependent N5,N10-methylenetetrahydromethanopterin reductase and a F420-dependent reductase involved in lincomycin biosynthesis in Streptomyces lincolnensis...
  95. ncbi Characterization of a 45-kDa flavoprotein and evidence for a rubredoxin, two proteins that could participate in electron transport from H2 to CO2 in methanogenesis in Methanobacterium thermoautotrophicum
    J NOLLING
    Department of Microbiology, Ohio State University, Columbus, USA
    Eur J Biochem 231:628-38. 1995
    ..abstract truncated at 400 words)..
  96. ncbi A unique organization of the protein subunits of the DNA polymerase clamp loader in the archaeon Methanobacterium thermoautotrophicum deltaH
    Z Kelman
    Department of Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 275:7327-36. 2000
    ..The importance and roles of RFC and PCNA in M. thermoautotrophicum DeltaH replication are discussed...

Research Grants11

  1. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2003
    ..This, in turn, will provide a framework for developing therapeutics specifically targeted against the class I lysyl-tRNA synthetase. ..
  2. Archaeal gene recruitment by the Chlamydiales
    David Graham; Fiscal Year: 2007
    ..Results from these experiments will support future microbiological studies of the role of this system in chlamydial infection and survival in the host cell. ..
  3. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2007
    ..This, in turn, will provide a framework for developing therapeutics specifically targeted against the class I lysyl-tRNA synthetase. ..
  4. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2006
    ..This, in turn, will provide a framework for developing therapeutics specifically targeted against the class I lysyl-tRNA synthetase. ..
  5. Biochemistry of lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2010
    ..The study will also provide further insights into the degree of functional diversity within the aaRS family in general, an emerging group of anti-microbial drug targets. ..