Trichoplax adhaerens



Top Publications

  1. Orosz F. Apicortin, a unique protein, with a putative cytoskeletal role, shared only by apicomplexan parasites and the placozoan Trichoplax adhaerens. Infect Genet Evol. 2009;9:1275-86 pubmed publisher
    ..Apicortin seems to occur only in the placozoan animal Trichoplax adhaerens and in each of the apicomplexan parasites, the genomes of which are available...
  2. Dellaporta S, Xu A, Sagasser S, Jakob W, Moreno M, Buss L, et al. Mitochondrial genome of Trichoplax adhaerens supports placozoa as the basal lower metazoan phylum. Proc Natl Acad Sci U S A. 2006;103:8751-6 pubmed publisher
    ..Here, we report the complete mitochondrial genome sequence of the placozoan Trichoplax adhaerens, a metazoan with the simplest known body plan of any animal, possessing no organs, no basal membrane, and ..
  3. Smith C, Reese T, Govezensky T, Barrio R. Coherent directed movement toward food modeled in Trichoplax, a ciliated animal lacking a nervous system. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
    i>Trichoplax adhaerens is a small, ciliated marine animal that glides on surfaces grazing upon algae, which it digests externally...
  4. Osigus H, Rolfes S, Herzog R, Kamm K, Schierwater B. Polyplacotoma mediterranea is a new ramified placozoan species. Curr Biol. 2019;29:R148-R149 pubmed publisher
    ..The original placozoan species Trichoplax adhaerens[3], the second species Hoilungia hongkongensis[1] and all yet undescribed species are morphologically ..
  5. Jekely G. Global view of the evolution and diversity of metazoan neuropeptide signaling. Proc Natl Acad Sci U S A. 2013;110:8702-7 pubmed publisher
    ..pNPs belonging to this cluster were also identified in the early-branching neuronless animal Trichoplax adhaerens. Clustering of neuropeptide GPCRs identified several orthology groups and allowed the reconstruction of the ..
  6. Lippl K, Boleininger A, McDonough M, Abboud M, Tarhonskaya H, Chowdhury R, et al. Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens. Hypoxia (Auckl). 2018;6:57-71 pubmed publisher
    ..PHDs) act as hypoxia sensors for the HIF system in organisms ranging from humans to the simplest animal Trichoplax adhaerens. We report structural and biochemical studies on the T...
  7. Varoqueaux F, Williams E, Grandemange S, Truscello L, Kamm K, Schierwater B, et al. High Cell Diversity and Complex Peptidergic Signaling Underlie Placozoan Behavior. Curr Biol. 2018;28:3495-3501.e2 pubmed publisher
    ..The placozoan Trichoplax adhaerens is a millimeter-wide, flat, free-living marine animal composed of six morphologically identified cell types ..
  8. Armon S, Bull M, Aranda Díaz A, Prakash M. Ultrafast epithelial contractions provide insights into contraction speed limits and tissue integrity. Proc Natl Acad Sci U S A. 2018;115:E10333-E10341 pubmed publisher
    ..of this cohesion, we study the epithelium mechanics of an ultrathin (∼25 μm) primitive marine animal Trichoplax adhaerens, composed essentially of two flat epithelial layers...
  9. Smith C, Varoqueaux F, Kittelmann M, Azzam R, Cooper B, Winters C, et al. Novel cell types, neurosecretory cells, and body plan of the early-diverging metazoan Trichoplax adhaerens. Curr Biol. 2014;24:1565-1572 pubmed publisher
    b>Trichoplax adhaerens is the best-known member of the phylum Placozoa, one of the earliest-diverging metazoan phyla. It is a small disk-shaped animal that glides on surfaces in warm oceans to feed on algae...

More Information


  1. Suurväli J, Jouneau L, Thépot D, Grusea S, Pontarotti P, Du Pasquier L, et al. The proto-MHC of placozoans, a region specialized in cellular stress and ubiquitination/proteasome pathways. J Immunol. 2014;193:2891-901 pubmed publisher
    ..identify a putative proto-MHC with archetypal markers in the most basal branch of Metazoans--the placozoan Trichoplax adhaerens, indicating that the proto-MHC is much older than previously believed--and present in the common ancestor ..
  2. Kamm K, Osigus H, Stadler P, DeSalle R, Schierwater B. Trichoplax genomes reveal profound admixture and suggest stable wild populations without bisexual reproduction. Sci Rep. 2018;8:11168 pubmed publisher
    The phylum Placozoa officially consists of only a single described species, Trichoplax adhaerens, although several lineages can be separated by molecular markers, geographical distributions and environmental demands...
  3. Reitzel A, Macrander J, Mané Padrós D, Fang B, Sladek F, Tarrant A. Conservation of DNA and ligand binding properties of retinoid X receptor from the placozoan Trichoplax adhaerens to human. J Steroid Biochem Mol Biol. 2018;184:3-10 pubmed publisher
    ..Among early-diverging animal lineages, the retinoid X receptor (RXR) is first detected in the placozoan, Trichoplax adhaerens. To gain insight into RXR evolution, we characterized ligand- and DNA-binding activity of the RXR from T...
  4. Mushegian A, Gurevich V, Gurevich E. The origin and evolution of G protein-coupled receptor kinases. PLoS ONE. 2012;7:e33806 pubmed publisher
    ..One representative of each of the two ancient clades is found as early as placozoan Trichoplax adhaerens. Several protists, two oomycetes and unicellular brown algae have one GRK-like protein, suggesting that the ..
  5. Layden M. Cnidarian Zic Genes. Adv Exp Med Biol. 2018;1046:27-39 pubmed publisher
    ..collectively are termed the parahoxozoans (cnidarians (corals, sea anemones, and jellyfish), placozoans (Trichoplax adhaerens), and bilaterians (chordates, insects, nematodes, annelids, echinoderms, etc.)...
  6. Mayorova T, Smith C, Hammar K, Winters C, Pivovarova N, Aronova M, et al. Cells containing aragonite crystals mediate responses to gravity in Trichoplax adhaerens (Placozoa), an animal lacking neurons and synapses. PLoS ONE. 2018;13:e0190905 pubmed publisher
    b>Trichoplax adhaerens has only six cell types. The function as well as the structure of crystal cells, the least numerous cell type, presented an enigma...
  7. Robertson H. The Insect Chemoreceptor Superfamily Is Ancient in Animals. Chem Senses. 2015;40:609-14 pubmed publisher
    ..GR-Like (GRL) genes are present in the genomes of the placozoan Trichoplax adhaerens, an anemone Nematostella vectensis, a coral Acropora digitifera, a polychaete Capitella teleta, a leech ..
  8. Selvan N, Mariappa D, van den Toorn H, Heck A, Ferenbach A, van Aalten D. The Early Metazoan Trichoplax adhaerens Possesses a Functional O-GlcNAc System. J Biol Chem. 2015;290:11969-82 pubmed publisher
    ..OGA), and nucleocytoplasmic protein O-GlcNAcylation in the most basal extant animal, the placozoan Trichoplax adhaerens. We show via enzymatic characterization of Trichoplax OGT/OGA and genetic rescue experiments in Drosophila ..
  9. Krishnan A, Schiöth H. The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system. J Exp Biol. 2015;218:562-71 pubmed publisher
    ..have primitive nervous systems (nerve nets), the demosponge Amphimedon queenslandica and the placozoan Trichoplax adhaerens, which lack nerve and muscle cells...
  10. Warren C, Kassir E, Spurlin J, Martinez J, Putnam N, Farach Carson M. Evolution of the perlecan/HSPG2 gene and its activation in regenerating Nematostella vectensis. PLoS ONE. 2015;10:e0124578 pubmed publisher
    ..After the recent sequencing of their genomes, the cnidarian Nematostella vectensis and the placozoan Trichoplax adhaerens have become favorite models for studying tissue regeneration and the evolution of multicellularity...
  11. Eitel M, Osigus H, DeSalle R, Schierwater B. Global diversity of the Placozoa. PLoS ONE. 2013;8:e57131 pubmed publisher
    ..b>Trichoplax adhaerens is the only formally described species in the phylum to date, making the Placozoa the only monotypic phylum ..
  12. Smith C, Reese T. Adherens Junctions Modulate Diffusion between Epithelial Cells in Trichoplax adhaerens. Biol Bull. 2016;231:216-224 pubmed publisher
    b>Trichoplax adhaerens is the sole named member of Placozoa, an ancient metazoan phylum. This coin-shaped animal glides on ventral cilia to find and digest algae on the substrate...
  13. Osigus H, Eitel M, Schierwater B. Deep RNA sequencing reveals the smallest known mitochondrial micro exon in animals: The placozoan cox1 single base pair exon. PLoS ONE. 2017;12:e0177959 pubmed publisher
    ..A previous study also suggested the existence of cox1 mRNA editing in Trichoplax adhaerens, yet the only formally described species in the phylum Placozoa...
  14. Mickael M, Rajput A, Steyn J, Wiemerslage L, Burglin T. An optimised phylogenetic method sheds more light on the main branching events of rhodopsin-like superfamily. Comp Biochem Physiol Part D Genomics Proteomics. 2016;20:85-94 pubmed publisher
    ..Our analysis indicated that basal receptors might be playing a role in early evolution of the nervous system. This is evident in Trichoplax adhaerens genome, where we located histamine receptors and adenosine receptors.
  15. Oddo J, Saxena T, McConnell O, Berglund J, Wang E. Conservation of context-dependent splicing activity in distant Muscleblind homologs. Nucleic Acids Res. 2016;44:8352-62 pubmed publisher
    ..We identified putative MBL homologs in Ciona intestinalis and Trichoplax adhaerens, and investigated their ability, as well as that of MBL homologs from human/mouse, fly and worm, to ..
  16. Orosz F. Wider than Thought Phylogenetic Occurrence of Apicortin, A Characteristic Protein of Apicomplexan Parasites. J Mol Evol. 2016;82:303-14 pubmed publisher
    ..Nitella mirabilis, found as Transcriptome Shotgun Assembly (TSA), are similar to the known Opisthokont (Trichoplax adhaerens, Spizellomyces punctatus) and Viridiplantae (Nicotiana tabacum) ones, since they do not contain the long, ..
  17. Liu Z, Yu Q, Yang C, Meng M, Ren C, Mu Z, et al. Transcription factor SGF1 is critical for the neurodevelopment in the silkworm, Bombyx mori. Gene. 2016;587:70-5 pubmed publisher
    ..Here, we show that the amino acids sequence of BmSGF1 is evolutionarily conserved in its middle region from Trichoplax adhaerens to human and diverged from the homologues in most other species in its N-terminal region...
  18. Novotný J, Chughtai A, Kostrouchová M, Kostrouchová V, Kostrouch D, Kaššák F, et al. Trichoplax adhaerens reveals a network of nuclear receptors sensitive to 9-cis-retinoic acid at the base of metazoan evolution. Peerj. 2017;5:e3789 pubmed publisher
    i>Trichoplax adhaerens, the only known species of Placozoa is likely to be closely related to an early metazoan that preceded branching of Cnidaria and Bilateria...
  19. Senatore A, Reese T, Smith C. Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses. J Exp Biol. 2017;220:3381-3390 pubmed publisher
    i>Trichoplax adhaerens is a flat, millimeter-sized marine animal that adheres to surfaces and grazes on algae...
  20. Smith C, Abdallah S, Wong Y, Le P, Harracksingh A, Artinian L, et al. Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue. J Gen Physiol. 2017;149:483-510 pubmed publisher
    ..Here, we characterize the single T-type calcium channel from Trichoplax adhaerens (TCav3), an early diverging animal that lacks muscle, neurons, and synapses...