Hydra vulgaris


Alias: Hydra attenuata, Hydra vulgaris Pallas, 1766

Top Publications

  1. Kurz E, Holstein T, Petri B, Engel J, David C. Mini-collagens in hydra nematocytes. J Cell Biol. 1991;115:1159-69 pubmed
    ..Electrophoretic characterization of nematocyst extracts allows resolution of small proline-rich polypeptides that correspond in size to the cloned sequences. ..
  2. Grens A, Mason E, Marsh J, Bode H. Evolutionary conservation of a cell fate specification gene: the Hydra achaete-scute homolog has proneural activity in Drosophila. Development. 1995;121:4027-35 pubmed
    ..We have isolated and characterized a cnidarian achaete-scute homolog, CnASH, from Hydra vulgaris, a representative of an evolutionarily ancient branch of metazoans...
  3. Koch A, Holstein T, Mala C, Kurz E, Engel J, David C. Spinalin, a new glycine- and histidine-rich protein in spines of Hydra nematocysts. J Cell Sci. 1998;111 ( Pt 11):1545-54 pubmed
  4. Cikala M, Wilm B, Hobmayer E, Bottger A, David C. Identification of caspases and apoptosis in the simple metazoan Hydra. Curr Biol. 1999;9:959-62 pubmed
    ..In the simple metazoan Hydra vulgaris, cell death regulates cell numbers [3] [4] [5]...
  5. Smith K, Gee L, Bode H. HyAlx, an aristaless-related gene, is involved in tentacle formation in hydra. Development. 2000;127:4743-52 pubmed
    ..The different patterns of HyAlx expression during head regeneration and bud formation also provide support for a recent version of a reaction-diffusion model for axial patterning in hydra. ..
  6. Herold M, Cikala M, MacWilliams H, David C, Böttger A. Cloning and characterisation of PKB and PRK homologs from Hydra and the evolution of the protein kinase family. Dev Genes Evol. 2002;212:513-9 pubmed
    ..The precursor for these kinases must have contained N-terminal regulatory domains that were retained in fungal PRKs but subsequently partitioned between kinases of the PKC and PRK groups in metazoans...
  7. Lindgens D, Holstein T, Technau U. Hyzic, the Hydra homolog of the zic/odd-paired gene, is involved in the early specification of the sensory nematocytes. Development. 2004;131:191-201 pubmed
    ..Our results suggest, that genetic cascades of neural development may be conserved from Hydra to vertebrates, indicating that the molecular regulation of neural development evolved only once...
  8. Fedders H, Augustin R, Bosch T. A Dickkopf- 3-related gene is expressed in differentiating nematocytes in the basal metazoan Hydra. Dev Genes Evol. 2004;214:72-80 pubmed
    ..They also suggest that vertebrate Dkk-1, 2 and 4 may have originated from a common ancestor gene of Dkk-3. ..
  9. Steele R, Hampson S, Stover N, Kibler D, Bode H. Probable horizontal transfer of a gene between a protist and a cnidarian. Curr Biol. 2004;14:R298-9 pubmed

More Information

Publications145 found, 100 shown here

  1. Khalturin K, Anton Erxleben F, Milde S, Plötz C, Wittlieb J, Hemmrich G, et al. Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation. Dev Biol. 2007;309:32-44 pubmed
  2. Hwang J, Takaku Y, Chapman J, Ikeo K, David C, Gojobori T. Cilium evolution: identification of a novel protein, nematocilin, in the mechanosensory cilium of Hydra nematocytes. Mol Biol Evol. 2008;25:2009-17 pubmed publisher
    ..Thus, the evolution of a novel ciliary structure, which provides mechanical rigidity to the sensory cilium during the process of mechanoreception, is associated with the evolution of a novel protein. ..
  3. Grens A, Gee L, Fisher D, Bode H. CnNK-2, an NK-2 homeobox gene, has a role in patterning the basal end of the axis in hydra. Dev Biol. 1996;180:473-88 pubmed
    ..Here we describe the characterization of the NK-2 homolog CnNK-2 from Hydra vulgaris, a freshwater cnidarian...
  4. Martinez D, Dirksen M, Bode P, Jamrich M, Steele R, Bode H. Budhead, a fork head/HNF-3 homologue, is expressed during axis formation and head specification in hydra. Dev Biol. 1997;192:523-36 pubmed
    ..Expression during later stages of budding, during head regeneration and the formation of ectopic heads, indicates a role in head formation. It is likely that budhead plays a critical role in head as well as axis formation in hydra. ..
  5. Stover N, Steele R. Trans-spliced leader addition to mRNAs in a cnidarian. Proc Natl Acad Sci U S A. 2001;98:5693-8 pubmed
    ..The presence and features of SL addition in the phylum Cnidaria raise interesting questions regarding the evolution of this process...
  6. Hoffmeister Ullerich S, Herrmann D, Kielholz J, Schweizer M, Schaller H. Isolation of a putative peroxidase, a target for factors controlling foot-formation in the coelenterate hydra. Eur J Biochem. 2002;269:4597-606 pubmed
    ..Transcripts of ppod2 are abundant in the whole animal with the exception of the hypostome, the tentacles, and the foot; the expression of ppod1 matches exactly the localization of the foot-specific peroxidase. ..
  7. Engel U, Ozbek S, Streitwolf Engel R, Petri B, Lottspeich F, Holstein T, et al. Nowa, a novel protein with minicollagen Cys-rich domains, is involved in nematocyst formation in Hydra. J Cell Sci. 2002;115:3923-34 pubmed
  8. Pauly B, Stiening B, Schade M, Alexandrova O, Zoubek R, David C, et al. Molecular cloning and cellular distribution of two 14-3-3 isoforms from Hydra: 14-3-3 proteins respond to starvation and bind to phosphorylated targets. Exp Cell Res. 2003;285:15-26 pubmed
    ..Moreover, 14-3-3 protein is present in large amounts in food granules and from this we conclude that it performs functions which are associated with metabolism and food storage in Hydra. ..
  9. Takahashi T, Hatta M, Yum S, Gee L, Ohtani M, Fujisawa T, et al. Hym-301, a novel peptide, regulates the number of tentacles formed in hydra. Development. 2005;132:2225-34 pubmed
    ..This indicates the range of expression of the gene appears to be controlled by this gradient. Thus, Hym-301 is involved in axial patterning in hydra, and specifically in the regulation of the number of tentacles formed. ..
  10. Thomsen S, Bosch T. Foot differentiation and genomic plasticity in Hydra: lessons from the PPOD gene family. Dev Genes Evol. 2006;216:57-68 pubmed
  11. Miller D, Hemmrich G, Ball E, Hayward D, Khalturin K, Funayama N, et al. The innate immune repertoire in cnidaria--ancestral complexity and stochastic gene loss. Genome Biol. 2007;8:R59 pubmed
    ..Consideration of these patterns of gene distribution underscores the likely significance of gene loss during animal evolution whilst indicating ancient origins for many components of the vertebrate innate immune system. ..
  12. Adamczyk P, Meier S, Gross T, Hobmayer B, Grzesiek S, Bachinger H, et al. Minicollagen-15, a novel minicollagen isolated from Hydra, forms tubule structures in nematocysts. J Mol Biol. 2008;376:1008-20 pubmed publisher
    ..Our data provide evidence for evolutionary diversification among minicollagens, which probably facilitated alterations in the morphology of the nematocyst wall and tubule. ..
  13. David C, Ozbek S, Adamczyk P, Meier S, Pauly B, Chapman J, et al. Evolution of complex structures: minicollagens shape the cnidarian nematocyst. Trends Genet. 2008;24:431-8 pubmed publisher
    ..We hypothesize that novel CRD motifs alter minicollagen networks, leading to novel capsule structures and nematocyst types. ..
  14. Khalturin K, Anton Erxleben F, Sassmann S, Wittlieb J, Hemmrich G, Bosch T. A novel gene family controls species-specific morphological traits in Hydra. PLoS Biol. 2008;6:e278 pubmed publisher
    ..These results suggest that "novel" genes may be involved in the generation of species-specific morphological traits...
  15. Lange C, Hemmrich G, Klostermeier U, López Quintero J, Miller D, Rahn T, et al. Defining the origins of the NOD-like receptor system at the base of animal evolution. Mol Biol Evol. 2011;28:1687-702 pubmed publisher
    ..These results add substantially to our understanding of the ancestral innate immune repertoire as well as providing the first insights into putative cytoplasmic defense mechanisms at the base of animal evolution. ..
  16. McKinley K, McLellan I, Gagné F, Quinn B. The toxicity of potentially toxic elements (Cu, Fe, Mn, Zn and Ni) to the cnidarian Hydra attenuata at environmentally relevant concentrations. Sci Total Environ. 2019;665:848-854 pubmed publisher
    ..In this study, the cnidarian Hydra attenuata was exposed individually and to a mixture of 5 metals (copper, iron, manganese, zinc and nickel) at ..
  17. Scharfenberg F, Serek Heuberger J, Coles M, Hartmann M, Habeck M, Martin J, et al. Structure and evolution of N-domains in AAA metalloproteases. J Mol Biol. 2015;427:910-923 pubmed publisher
    ..Our bioinformatic analysis showed that, uniquely among these proteins, the N-domain of Yme1 from the cnidarian Hydra vulgaris contains both the tetratricopeptide repeat region seen in basal metazoans and a region of homology to the N-..
  18. Rojas Pérez Y, Etchenique R. Optical manipulation of animal behavior using a ruthenium-based phototrigger. Photochem Photobiol Sci. 2019;18:208-212 pubmed publisher
    ..based on a ruthenium-polypyridine complex was used to elicit the feeding response of the freshwater cnidarian Hydra vulgaris. The phototrigger delivers l-arginine in a clean reaction under irradiation with blue or green light...
  19. De Jong L, Pech N, de Aragão Umbuzeiro G, Moreau X. Multi-scale biomarker evaluation of the toxicity of a commercial azo dye (Disperse Red 1) in an animal model, the freshwater cnidarian Hydra attenuata. Water Res. 2016;96:62-73 pubmed publisher
    ..of the commercial azo dye Disperse Red 1 (DR1) using various biomarkers in the freshwater invertebrate Hydra attenuata. Morphological changes have been selected to calculate ecotoxicological thresholds for sublethal and lethal ..
  20. Blaise C, Gagné F, Harwood M, Quinn B, Hanana H. Ecotoxicity responses of the freshwater cnidarian Hydra attenuata to 11 rare earth elements. Ecotoxicol Environ Saf. 2018;163:486-491 pubmed publisher
    ..an ecologically relevant freshwater community, thus prompted the present research on REEs toxicity using Hydra attenuata as our animal model...
  21. Dong W, Zhang H, Wang R, Pan H. Molecular cloning, antiserum preparation and expression analysis during head regeneration of α-crystallin type heat shock protein in Hydra vulgaris. J Genet. 2018;97:911-924 pubmed
    ..was one of the numerous cDNA sequences expressed differentially at various stages of head regeneration in Hydra vulgaris...
  22. Layden M. Cnidarian Zic Genes. Adv Exp Med Biol. 2018;1046:27-39 pubmed publisher
    ..in the parahoxozoans with a particular focus on how expression of cnidarian zic homologs in the medusozoan Hydra vulgaris and the anthozoan Nematostella vectensis informs our understanding of the putative ancestral roles zic ..
  23. Pierobon P. Regional modulation of the response to glutathione in Hydra vulgaris. J Exp Biol. 2015;218:2226-32 pubmed publisher
    ..These results suggest a regional distribution of receptors to GABA and glycine in the neuromuscular circuitry modulating the feeding behaviour. ..
  24. Traversetti L, Del Grosso F, Malafoglia V, Colasanti M, Ceschin S, Larsen S, et al. The Hydra regeneration assay reveals ecological risks in running waters: a new proposal to detect environmental teratogenic threats. Ecotoxicology. 2017;26:184-195 pubmed publisher
    The regenerative ability of Hydra vulgaris was tested as potential biomarker for the development of a new eco-toxicological index...
  25. Dellamatrice P, Silva Stenico M, Moraes L, Fiore M, Monteiro R. Degradation of textile dyes by cyanobacteria. Braz J Microbiol. 2017;48:25-31 pubmed publisher
    ..The discoloration was evaluated by absorption spectroscopy. Toxicity was measured using the organisms Hydra attenuata, the alga Selenastrum capricornutum and lettuce seeds...
  26. Nicosia A, Bennici C, Biondo G, Costa S, Di Natale M, Masullo T, et al. Characterization of Translationally Controlled Tumour Protein from the Sea Anemone Anemonia viridis and Transcriptome Wide Identification of Cnidarian Homologues. Genes (Basel). 2018;9: pubmed publisher
    ..genome sequence of Acropora digitifera, Exaiptasia pallida, Nematostella vectensis and Hydra vulgaris enabled a comprehensive study of the molecular evolution of TCTP family among cnidarians...
  27. Gonçalves S, Strauss M, Delite F, Clemente Z, Castro V, Martinez D. Activated carbon from pyrolysed sugarcane bagasse: Silver nanoparticle modification and ecotoxicity assessment. Sci Total Environ. 2016;565:833-840 pubmed publisher
    ..However, ACPB-AgNP showed environmental risks, with toxic effect to the aquatic organism Hydra attenuata (i.e. LC50 value of 1...
  28. Bräuer K, Brockers K, Moneer J, Feuchtinger A, Wollscheid Lengeling E, Lengeling A, et al. Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2 (Mina53) provide new insights into their evolution. BMC Evol Biol. 2018;18:96 pubmed publisher
    ..Immunofluorescence analyses in Hela cells and in Hydra vulgaris identified a nucleolar localisation signal within the extended N-terminal domain of human RIOX1 and an altered ..
  29. Badhiwala K, Gonzales D, Vercosa D, Avants B, Robinson J. Microfluidics for electrophysiology, imaging, and behavioral analysis of Hydra. Lab Chip. 2018;18:2523-2539 pubmed publisher
    The nervous system of the cnidarian Hydra vulgaris exhibits remarkable regenerative abilities. When cut in two, the bisected tissue reorganizes into fully behaving animals in approximately 48 hours...
  30. Godoy A, Domingues I, Arsénia Nogueira A, Kummrow F. Ecotoxicological effects, water quality standards and risk assessment for the anti-diabetic metformin. Environ Pollut. 2018;243:534-542 pubmed publisher
    ..To the best of our knowledge, this study presents the first data related with MET effects on population endpoints of D. similis and Hydra attenuata, as well as on the locomotor activity of D. rerio.
  31. Tortiglione C, Quarta A, Malvindi M, Tino A, Pellegrino T. Fluorescent nanocrystals reveal regulated portals of entry into and between the cells of Hydra. PLoS ONE. 2009;4:e7698 pubmed publisher
    ..Here we show that the cell uptake of fluorescent CdSe/CdS quantum rods (QRs) by Hydra vulgaris, a simple model organism at the base of metazoan evolution, can be tuned by modifying nanoparticle surface ..
  32. Bridge D, Theofiles A, Holler R, Marcinkevicius E, Steele R, Martínez D. FoxO and stress responses in the cnidarian Hydra vulgaris. PLoS ONE. 2010;5:e11686 pubmed publisher
    ..These findings imply that basic mechanisms of FoxO regulation arose before the evolution of bilaterians and raise the possibility that FoxO is involved in stress responses of other cnidarian species, including corals. ..
  33. González V, Vignati D, Pons M, Montarges Pelletier E, Bojic C, Giamberini L. Lanthanide ecotoxicity: first attempt to measure environmental risk for aquatic organisms. Environ Pollut. 2015;199:139-47 pubmed publisher
    ..increased with atomic number, while Daphnia magna, Heterocypris incongruens, Brachionus calyciflorus and Hydra attenuata were equally sensitive to the tested elements...
  34. Morrill G, Kostellow A, Liu L, Gupta R, Askari A. Evolution of the α-Subunit of Na/K-ATPase from Paramecium to Homo sapiens: Invariance of Transmembrane Helix Topology. J Mol Evol. 2016;82:183-98 pubmed publisher
    ..with membrane lipid rafts and cell signaling reveal significant positional shifts between Paramecium and Hydra vulgaris, indicating that regional membrane fluidity changes occur during evolution...
  35. Khalturin K, Billas I, Chebaro Y, Reitzel A, Tarrant A, Laudet V, et al. NR3E receptors in cnidarians: A new family of steroid receptor relatives extends the possible mechanisms for ligand binding. J Steroid Biochem Mol Biol. 2018;184:11-19 pubmed publisher
    ..We discovered serendipitously that a cytoplasmic factor within epidermal cells of transgenic Hydra vulgaris can trigger the nuclear translocation of heterologously expressed human ERα...
  36. Hartl M, Mitterstiller A, Valovka T, Breuker K, Hobmayer B, Bister K. Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra. Proc Natl Acad Sci U S A. 2010;107:4051-6 pubmed publisher
    ..Our results suggest that the principal functions of the Myc master regulator arose very early in metazoan evolution, allowing their dissection in a simple model organism showing regenerative ability but no senescence...
  37. Fraune S, Augustin R, Anton Erxleben F, Wittlieb J, Gelhaus C, Klimovich V, et al. In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. Proc Natl Acad Sci U S A. 2010;107:18067-72 pubmed publisher
    ..These findings delineate a role for antimicrobial peptides both in selecting particular bacterial partners during development and as important components of a "be prepared" strategy providing transgenerational protection. ..
  38. Minguez L, Di Poi C, Farcy E, Ballandonne C, Benchouala A, Bojic C, et al. Comparison of the sensitivity of seven marine and freshwater bioassays as regards antidepressant toxicity assessment. Ecotoxicology. 2014;23:1744-54 pubmed publisher
    ..immobilization test (Artemia salina and Daphnia magna), development and adult survival tests on Hydra attenuata, embryotoxicity and metamorphosis tests on Crassostrea gigas, and in vitro assays on primary cultures of ..
  39. Li X, Lachnit T, Fraune S, Bosch T, Traulsen A, Sieber M. Temperate phages as self-replicating weapons in bacterial competition. J R Soc Interface. 2017;14: pubmed publisher
    ..Here, we study the interaction between two key members of the microbiota of the freshwater metazoan Hydra vulgaris The two commensal bacteria Curvibacter sp. and Duganella sp...
  40. Marchesano V, Ambrosone A, Bartelmess J, Strisciante F, Tino A, Echegoyen L, et al. Impact of Carbon Nano-Onions on Hydra vulgaris as a Model Organism for Nanoecotoxicology. Nanomaterials (Basel). 2015;5:1331-1350 pubmed publisher
    ..of pristine and chemically modified carbon nano-onions (CNOs) on the development of the freshwater polyp Hydra vulgaris were investigated in order to elucidate the ecotoxicological effects of CNOs...
  41. D rrnagel S, Kuhn A, Tsiairis C, Williamson M, Kalbacher H, Grimmelikhuijzen C, et al. Three homologous subunits form a high affinity peptide-gated ion channel in Hydra. J Biol Chem. 2010;285:11958-65 pubmed publisher
    ..Collectively, our results suggest that the three homologous subunits HyNaC2, -3, and -5 form a peptide-gated ion channel in Hydra that could contribute to fast synaptic transmission...
  42. Hobmayer B, Rentzsch F, Holstein T. Identification and expression of HySmad1, a member of the R-Smad family of TGFbeta signal transducers, in the diploblastic metazoan Hydra. Dev Genes Evol. 2001;211:597-602 pubmed publisher
    ..This suggests that multiple functions of TGFbeta/Smad signaling might be conserved between diploblastic and triploblastic metazoans...
  43. Evangelista D, Tripathi K, Guarracino M. An Atlas of annotations of Hydra vulgaris transcriptome. BMC Bioinformatics. 2016;17:360 pubmed publisher
    ..to provide to the users an advantageous resource that include the whole functional annotated transcriptome of Hydra vulgaris water polyp, we implemented the Atlas web-tool contains 31...
  44. Zhang X, Boot Handford R, Huxley Jones J, Forse L, Mould A, Robertson D, et al. The collagens of hydra provide insight into the evolution of metazoan extracellular matrices. J Biol Chem. 2007;282:6792-802 pubmed publisher
    ..multiple von Willebrand factor A domains interspersed with interrupted collagenous triple helices (Hcol6) from Hydra vulgaris. Hcol2 and -5 have major collagenous domains of classical length ( approximately 1020 amino acid residues), ..
  45. Costa S, Pinto P, Saraiva M, Rocha F, Santos J, Monteiro R. The aquatic impact of ionic liquids on freshwater organisms. Chemosphere. 2015;139:288-94 pubmed publisher
    ..used organic solvents was evaluated using freshwater organisms: Daphnia magna, Raphidocelis subcapitata and Hydra attenuata. The bioassays were performed by exposing the organisms to increasing concentrations of the ILs and observing ..
  46. Ishikawa M, Shimizu H, Nozawa M, Ikeo K, Gojobori T. Two-step evolution of endosymbiosis between hydra and algae. Mol Phylogenet Evol. 2016;103:19-25 pubmed publisher
    In the Hydra vulgaris group, only 2 of the 25 strains in the collection of the National Institute of Genetics in Japan currently show endosymbiosis with green algae...
  47. Canfield V, Xu K, D Aquila T, Shyjan A, Levenson R. Molecular cloning and characterization of Na,K-ATPase from Hydra vulgaris: implications for enzyme evolution and ouabain sensitivity. New Biol. 1992;4:339-48 pubmed
    We have used molecular and biochemical techniques to analyze Na,K-ATPase from a simple metazoan, Hydra vulgaris. First we isolated and characterized cDNA clones encoding the Na,K-ATPase alpha subunit from a Hydra lambda gt11 cDNA library...
  48. Dash B, Phillips T. Molecular characterization of a catalase from Hydra vulgaris. Gene. 2012;501:144-52 pubmed publisher
    ..In this work an apparent full length cDNA sequence coding for a catalase (HvCatalase) was isolated from Hydra vulgaris using 3'- and 5'- (RLM) RACE approaches...
  49. Dupré C, Yuste R. Non-overlapping Neural Networks in Hydra vulgaris. Curr Biol. 2017;27:1085-1097 pubmed publisher
    ..We have achieved this with the cnidarian Hydra vulgaris, using calcium imaging of genetically engineered animals to measure the activity of essentially all of its ..
  50. Gauchat D, Mazet F, Berney C, Schummer M, Kreger S, Pawlowski J, et al. Evolution of Antp-class genes and differential expression of Hydra Hox/paraHox genes in anterior patterning. Proc Natl Acad Sci U S A. 2000;97:4493-8 pubmed
    ..However, the positional information defining the oral/aboral axis in Hydra cannot be correlated strictly to that characterizing the anterior-posterior axis in vertebrates or arthropods...
  51. Juliano C, Reich A, Liu N, Götzfried J, Zhong M, Uman S, et al. PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells. Proc Natl Acad Sci U S A. 2014;111:337-42 pubmed publisher
    ..This comprehensive analysis of the PIWI-piRNA pathway in the somatic stem/progenitor cells of a nonbilaterian animal suggests that this pathway originated with broader stem cell functionality. ..
  52. Hampe W, Urny J, Franke I, Hoffmeister Ullerich S, Herrmann D, Petersen C, et al. A head-activator binding protein is present in hydra in a soluble and a membrane-anchored form. Development. 1999;126:4077-86 pubmed
    ..Secretion of HAB during regeneration and expression in regions of high determination potential hint at a role for HAB in regulating the concentration and range of action of head activator. ..
  53. Leviev I, Williamson M, Grimmelikhuijzen C. Molecular cloning of a preprohormone from Hydra magnipapillata containing multiple copies of Hydra-L Wamide (Leu-Trp-NH2) neuropeptides: evidence for processing at Ser and Asn residues. J Neurochem. 1997;68:1319-25 pubmed
  54. Herrmann D, Hatta M, Hoffmeister Ullerich S. Thypedin, the multi copy precursor for the hydra peptide pedin, is a beta-thymosin repeat-like domain containing protein. Mech Dev. 2005;122:1183-93 pubmed publisher
    ..Since actin polymerisation and depolymerisation processes are known to take place during morphogenetic processes, these findings may hint at new aspects of the function of pedin and its precursor in pattern formation in hydra...
  55. McLaughlin S. Evidence that polycystins are involved in Hydra cnidocyte discharge. Invert Neurosci. 2017;17:1 pubmed publisher
  56. Bosch T, Benitez E, Gellner K, Praetzel G, Salgado L. Cloning of a ras-related gene from Hydra which responds to head-specific signals. Gene. 1995;167:191-5 pubmed
    ..Plenum Press, New York, NY, 1993, pp. 237-253]. The finding that Hydra ras2 expression is strongly dependent on a signal from the head provides the first evidence for ras expression being regulated in pattern formation. ..
  57. Erber A, Riemer D, Hofemeister H, Bovenschulte M, Stick R, Panopoulou G, et al. Characterization of the Hydra lamin and its gene: A molecular phylogeny of metazoan lamins. J Mol Evol. 1999;49:260-71 pubmed
    ..elegans has the most diverse lamin sequence. Finally we discuss the possibility that two lamin types, a constitutively expressed one and a developmentally regulated one, arose independently on the arthropod and vertebrate lineages...
  58. Lim R, Anand A, Nishimiya Fujisawa C, Kobayashi S, Kai T. Analysis of Hydra PIWI proteins and piRNAs uncover early evolutionary origins of the piRNA pathway. Dev Biol. 2014;386:237-51 pubmed publisher
    ..These results indicate that various conserved features of PIWI proteins, the piRNA pathway, and their associations with the nuage were likely established before the evolution of bilaterians. ..
  59. Hassel M, Bridge D, Stover N, Kleinholz H, Steele R. The level of expression of a protein kinase C gene may be an important component of the patterning process in Hydra. Dev Genes Evol. 1998;207:502-14 pubmed
    ..We have cloned a gene (HvPKC2) from Hydra vulgaris which encodes a member of the nPKC subfamily...
  60. Yum S, Takahashi T, Hatta M, Fujisawa T. The structure and expression of a preprohormone of a neuropeptide, Hym-176 in Hydra magnipapillata. FEBS Lett. 1998;439:31-4 pubmed
    ..No signals were detected in the two extremities of the body, tentacles and basal disk. The expression pattern is correlated with the distribution of Hym-176 and its myoactive function. ..
  61. Hufnagel L, Kass Simon G. The two nerve rings of the hypostomal nervous system of Hydra vulgaris-an immunohistochemical analysis. Cell Tissue Res. 2016;366:255-269 pubmed publisher
    In Hydra vulgaris, physiological and pharmacological evidence exists for a hypostomal circumferential neuro-effector pathway that initiates ectodermal pacemaker activity at tentacular-hypostomal loci coordinating body and tentacle ..
  62. Harafuji N, Takahashi T, Hatta M, Tezuka H, Morishita F, Matsushima O, et al. Enhancement of foot formation in Hydra by a novel epitheliopeptide, Hym-323. Development. 2001;128:437-46 pubmed
    ..Lateral transplantation experiments indicated that the foot activation potential was increased in the peptide-treated tissue. These results suggest that Hym-323 is a peptide involved in a foot-patterning process in Hydra. ..
  63. Sudhop S, Coulier F, Bieller A, Vogt A, Hotz T, Hassel M. Signalling by the FGFR-like tyrosine kinase, Kringelchen, is essential for bud detachment in Hydra vulgaris. Development. 2004;131:4001-11 pubmed publisher
    ..Although Kringelchen groups with the FGFR family, it is not known whether this protein is able to bind FGFs, which have not been isolated from Hydra so far...
  64. Bosch T, Unger T, Fisher D, Steele R. Structure and expression of STK, a src-related gene in the simple metazoan Hydra attenuata. Mol Cell Biol. 1989;9:4141-51 pubmed
    ..a 509-amino-acid protein that is 64% similar to chicken pp60c-src were isolated from the simple metazoan Hydra attenuata. We have designated this gene STK, for src-type kinase...
  65. Alexopoulos H, B ttger A, Fischer S, Levin A, Wolf A, Fujisawa T, et al. Evolution of gap junctions: the missing link?. Curr Biol. 2004;14:R879-80 pubmed publisher
  66. Côa F, Strauss M, Clemente Z, Rodrigues Neto L, Lopes J, Alencar R, et al. Coating carbon nanotubes with humic acid using an eco-friendly mechanochemical method: Application for Cu(II) ions removal from water and aquatic ecotoxicity. Sci Total Environ. 2017;607-608:1479-1486 pubmed publisher
    ..The HA-MWCNTs hybrid material did not show acute ecotoxicity to the tested aquatic model organisms (Hydra attenuata, Daphnia magna, and Danio rerio embryos) up to the highest concentration evaluated (10mgL-1)...
  67. Yan L, Pollock G, Nagase H, Sarras M. A 25.7 x 10(3) M(r) hydra metalloproteinase (HMP1), a member of the astacin family, localizes to the extracellular matrix of Hydra vulgaris in a head-specific manner and has a developmental function. Development. 1995;121:1591-602 pubmed
    ..These studies indicated that HMP1 has a functional role during a number of developmental processes such as head regeneration and cell differentiation/transdifferentiation of tentacle battery cells. ..
  68. Augustin R, Siebert S, Bosch T. Identification of a kazal-type serine protease inhibitor with potent anti-staphylococcal activity as part of Hydra's innate immune system. Dev Comp Immunol. 2009;33:830-7 pubmed publisher
  69. Sarras M, Yan L, Grens A, Zhang X, Agbas A, Huff J, et al. Cloning and biological function of laminin in Hydra vulgaris. Dev Biol. 1994;164:312-24 pubmed publisher
    ..in additional functional studies and to screen a cDNA expression library made from poly(A)+ RNA isolated from Hydra vulgaris. Immunofluorescent analysis indicated that mAb52 was localized along the entire longitudinal axis of adult ..
  70. Concas A, Imperatore R, Santoru F, Locci A, Porcu P, Cristino L, et al. Immunochemical Localization of GABAA Receptor Subunits in the Freshwater Polyp Hydra vulgaris (Cnidaria, Hydrozoa). Neurochem Res. 2016;41:2914-2922 pubmed
    ..acid (GABA) receptors, responding to GABA positive allosteric modulators, are present in the freshwater polyp Hydra vulgaris (Cnidaria, Hydrozoa), one of the most primitive metazoans to develop a nervous system...
  71. Golubovic A, Kuhn A, Williamson M, Kalbacher H, Holstein T, Grimmelikhuijzen C, et al. A peptide-gated ion channel from the freshwater polyp Hydra. J Biol Chem. 2007;282:35098-103 pubmed publisher
    ..Our results suggest that neuropeptides were already used for fast transmission in ancient nervous systems...
  72. Chan S, Oliva A, LaMendola J, Grens A, Bode H, Steiner D. Conservation of the prohormone convertase gene family in metazoa: analysis of cDNAs encoding a PC3-like protein from hydra. Proc Natl Acad Sci U S A. 1992;89:6678-82 pubmed
    ..cDNAs encoding a protein that is similar in structure to PC3 from a simple metazoan, Hydra vulgaris (formerly Hydra attenuata)...
  73. Yan L, Fei K, Zhang J, Dexter S, Sarras M. Identification and characterization of hydra metalloproteinase 2 (HMP2): a meprin-like astacin metalloproteinase that functions in foot morphogenesis. Development. 2000;127:129-41 pubmed
    ..We have characterized a new astacin proteinase, hydra metalloproteinase 2 (HMP2) from the Cnidarian, Hydra vulgaris. HMP2 is translated from a single mRNA of 1...
  74. Minobe S, Fei K, Yan L, Sarras M, Werle M. Identification and characterization of the epithelial polarity receptor "Frizzled" in Hydra vulgaris. Dev Genes Evol. 2000;210:258-62 pubmed publisher
    ..Here we report the isolation and characterization of a putative Wnt receptor, Frizzled, in Hydra vulgaris. Analysis of the amino acid sequence of Frizzled in hydra reveals that this receptor contains many strong ..
  75. Hayakawa E, Takahashi T, Nishimiya Fujisawa C, Fujisawa T. A novel neuropeptide (FRamide) family identified by a peptidomic approach in Hydra magnipapillata. FEBS J. 2007;274:5438-48 pubmed publisher
    ..In contrast, FRamide-2 evoked body column contraction. These results suggest that both of the neuropeptides directly act on epithelial cells as neurotransmitters and regulate body movement in an axial direction...
  76. Milde S, Hemmrich G, Anton Erxleben F, Khalturin K, Wittlieb J, Bosch T. Characterization of taxonomically restricted genes in a phylum-restricted cell type. Genome Biol. 2009;10:R8 pubmed publisher
    ..The transcriptional regulatory network controlling taxonomically restricted gene expression may contain not yet characterized transcription factors or cis-regulatory elements...
  77. Takahashi T, Koizumi O, Hayakawa E, Minobe S, Suetsugu R, Kobayakawa Y, et al. Further characterization of the PW peptide family that inhibits neuron differentiation in Hydra. Dev Genes Evol. 2009;219:119-29 pubmed publisher
    ..Together with Hym-355, the PW family peptides mediate communication between neurons and epithelial cells and thereby maintain a specific density of neurons in Hydra...
  78. Philipp I, Aufschnaiter R, Ozbek S, Pontasch S, Jenewein M, Watanabe H, et al. Wnt/beta-catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra. Proc Natl Acad Sci U S A. 2009;106:4290-5 pubmed publisher
    ..Our results indicate that integration of axial patterning and tissue morphogenesis by the coordinated action of canonical and noncanonical Wnt pathways was crucial for the evolution of eumetazoan body plans...
  79. Boehm A, Khalturin K, Anton Erxleben F, Hemmrich G, Klostermeier U, López Quintero J, et al. FoxO is a critical regulator of stem cell maintenance in immortal Hydra. Proc Natl Acad Sci U S A. 2012;109:19697-702 pubmed publisher
    ..These findings contribute to a molecular understanding of Hydra's immortality, indicate an evolutionarily conserved role of FoxO in controlling longevity from Hydra to humans, and have implications for understanding cellular aging. ..
  80. Chan T, Chu C, Rauen K, Kroiher M, Tatarewicz S, Steele R. Identification of a gene encoding a novel protein-tyrosine kinase containing SH2 domains and ankyrin-like repeats. Oncogene. 1994;9:1253-9 pubmed
    ..kinase domain of protein-tyrosine kinases, we amplified segments of several protein-tyrosine kinase genes from Hydra vulgaris, a member of the ancient metazoan phylum Cnidaria...
  81. Deutzmann R, Fowler S, Zhang X, Boone K, Dexter S, Boot Handford R, et al. Molecular, biochemical and functional analysis of a novel and developmentally important fibrillar collagen (Hcol-I) in hydra. Development. 2000;127:4669-80 pubmed
    ..Hcol-I therefore illustrates an adaptive trait in which the normal physiological situation in hydra translates into a pathological condition in humans...
  82. Lohmann J, Bosch T. The novel peptide HEADY specifies apical fate in a simple radially symmetric metazoan. Genes Dev. 2000;14:2771-7 pubmed
    ..Thus, the HEADY peptide acts as developmental switch to pattern the apical-basal axis of Hydra, providing a first insight into how initial asymmetry is specified in lower metazoan animals...
  83. Hoffmeister Ullerich S. The foot formation stimulating peptide pedibin is also involved in patterning of the head in hydra. Mech Dev. 2001;106:37-45 pubmed
    ..This is confirmed by the finding that pedibin also stimulates bud outgrowth...
  84. Genikhovich G, K rn U, Hemmrich G, Bosch T. Discovery of genes expressed in Hydra embryogenesis. Dev Biol. 2006;289:466-81 pubmed publisher
    ..213, 445-455). Here, we describe an unbiased screening strategy to identify genes that are relevant to Hydra vulgaris embryogenesis...
  85. Guder C, Philipp I, Lengfeld T, Watanabe H, Hobmayer B, Holstein T. The Wnt code: cnidarians signal the way. Oncogene. 2006;25:7450-60 pubmed publisher
  86. Bielen H, Oberleitner S, Marcellini S, Gee L, Lemaire P, Bode H, et al. Divergent functions of two ancient Hydra Brachyury paralogues suggest specific roles for their C-terminal domains in tissue fate induction. Development. 2007;134:4187-97 pubmed publisher
    ..Our data support the concept of sub- and neofunctionalisation upon gene duplication and show that divergence of cis-regulation and coding sequence in paralogues can lead to dramatic changes in structure and function...
  87. Dana C, Glauber K, Chan T, Bridge D, Steele R. Incorporation of a horizontally transferred gene into an operon during cnidarian evolution. PLoS ONE. 2012;7:e31643 pubmed publisher
    ..The identification of operons in Hydra also provides a tool that can be exploited in the construction of transgenic Hydra strains. ..
  88. Murphy F, Quinn B. The effects of microplastic on freshwater Hydra attenuata feeding, morphology & reproduction. Environ Pollut. 2018;234:487-494 pubmed publisher
    ..Here we examine the effect of microplastics on the freshwater cnidarian, Hydra attenuata. This study also describes the development and use of a bioassay to investigate the impact of microplastic on ..
  89. Grens A, Shimizu H, Hoffmeister S, Bode H, Fujisawa T. The novel signal peptides, pedibin and Hym-346, lower positional value thereby enhancing foot formation in hydra. Development. 1999;126:517-24 pubmed
    ..Two novel peptides, pedibin and Hym-346, that are closely related to one another have been isolated from Hydra vulgaris and Hydra magnipapillata...
  90. Kumpfm ller G, Rybakine V, Takahashi T, Fujisawa T, Bosch T. Identification of an astacin matrix metalloprotease as target gene for Hydra foot activator peptides. Dev Genes Evol. 1999;209:601-7 pubmed
    ..Thus metalloproteinase Farm1 is a transcriptional target of positional signals specifying foot differentiation and appears to play a potent role in basal patterning processes...
  91. Hobmayer B, Rentzsch F, Kuhn K, Happel C, von Laue C, Snyder P, et al. WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra. Nature. 2000;407:186-9 pubmed publisher
    ..Our results indicate that Wnt signalling may be involved in axis formation in Hydra and support the idea that it was central in the evolution of axial differentiation in early multicellular animals...
  92. Bosch T, Augustin R, Anton Erxleben F, Fraune S, Hemmrich G, Zill H, et al. Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Dev Comp Immunol. 2009;33:559-69 pubmed publisher
    ..Conventional Toll-like receptors (TLRs) are absent in the Hydra genome. Our findings support the hypothesis that the epithelium represents the ancient system of host defence...