Caenorhabditis elegans

Summary

Alias: nematode, Caenorhabditis elegans (Maupas, 1900), Rhabditis elegans, Rhabditis elegans Maupas, 1900

Top Publications

  1. Settivari R, Vanduyn N, Levora J, Nass R. The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism. Neurotoxicology. 2013;38:51-60 pubmed publisher
    ..In this study we demonstrate that a Caenorhabditis elegans GSTÏ€ homologue, GST-1, inhibits Mn-induced DA neuron degeneration...
  2. Simon M, Sarkies P, Ikegami K, Doebley A, Goldstein L, Mitchell J, et al. Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants. Cell Rep. 2014;7:762-73 pubmed publisher
  3. Starich T, Hall D, Greenstein D. Two classes of gap junction channels mediate soma-germline interactions essential for germline proliferation and gametogenesis in Caenorhabditis elegans. Genetics. 2014;198:1127-53 pubmed publisher
    ..innexin proteins, in supporting the proliferation of germline stem cells and gametogenesis in the nematode Caenorhabditis elegans. Transmission electron microscopy of freeze-fracture replicas and fluorescence microscopy show that gap ..
  4. Smith Vikos T, de Lencastre A, Inukai S, Shlomchik M, Holtrup B, Slack F. MicroRNAs mediate dietary-restriction-induced longevity through PHA-4/FOXA and SKN-1/Nrf transcription factors. Curr Biol. 2014;24:2238-46 pubmed publisher
    ..factors PHA-4/FOXA and SKN-1/Nrf, which are both necessary for DR-induced lifespan extension in Caenorhabditis elegans. Our network analysis has revealed extensive regulatory interactions between PHA-4, SKN-1, and miRNAs and ..
  5. Ooi S, Lim T, Lee S, Nathan S. Burkholderia pseudomallei kills Caenorhabditis elegans through virulence mechanisms distinct from intestinal lumen colonization. Virulence. 2012;3:485-96 pubmed publisher
    The nematode Caenorhabditis elegans is hypersusceptible to Burkholderia pseudomallei infection. However, the virulence mechanisms underlying rapid lethality of C. elegans upon B. pseudomallei infection remain poorly defined...
  6. Edwards M, Johnson J, Rankin K, Jenkins R, Maguire C, Morgan A, et al. PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion. J Neurosci. 2012;32:7042-51 pubmed publisher
    ..This is certainly true in Caenorhabditis elegans and in particular for thermosensory signaling and behavior...
  7. Tocchini C, Keusch J, Miller S, Finger S, Gut H, Stadler M, et al. The TRIM-NHL protein LIN-41 controls the onset of developmental plasticity in Caenorhabditis elegans. PLoS Genet. 2014;10:e1004533 pubmed publisher
    ..To understand how the oocyte reprogramming potential is controlled, we sought Caenorhabditis elegans mutants in which embryonic transcription is initiated precociously in germ cells...
  8. Kamminga L, Van Wolfswinkel J, Luteijn M, Kaaij L, Bagijn M, Sapetschnig A, et al. Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans. PLoS Genet. 2012;8:e1002702 pubmed publisher
    ..Here we describe the effects of the Caenorhabditis elegans HEN1 RNA-methyl-transferase homolog, HENN-1, on the different RNAi pathways in this nematode...
  9. Masoudi N, Fancsalszky L, Pourkarimi E, Vellai T, Alexa A, Reményi A, et al. The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans. Development. 2013;140:3486-95 pubmed publisher
    ..effects of functional compensation between closely related Nm23 family members, we studied ndk-1, the sole Caenorhabditis elegans ortholog of group I NDPKs, and focused on its role in Ras/mitogen-activated protein kinase (MAPK)-mediated ..

More Information

Publications349 found, 100 shown here

  1. Winter J, Höpfner S, Korn K, Farnung B, Bradshaw C, Marsico G, et al. Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity. Nat Cell Biol. 2012;14:666-76 pubmed publisher
    ..Our data suggest that PAR-5 acts as a regulatory hub for a polarity-maintaining network required for apicobasal asymmetry of F-actin and proper Rab11-RE positioning. ..
  2. Baker B, Nargund A, Sun T, Haynes C. Protective coupling of mitochondrial function and protein synthesis via the eIF2? kinase GCN-2. PLoS Genet. 2012;8:e1002760 pubmed publisher
    ..eIF2? phosphorylation is required for development as well as the lifespan extension observed in Caenorhabditis elegans. Reactive oxygen species (ROS) generated from dysfunctional mitochondria are required for GCN-2-dependent ..
  3. Stamper E, Rodenbusch S, Rosu S, Ahringer J, Villeneuve A, Dernburg A. Identification of DSB-1, a protein required for initiation of meiotic recombination in Caenorhabditis elegans, illuminates a crossover assurance checkpoint. PLoS Genet. 2013;9:e1003679 pubmed publisher
    ..characterized a novel gene, dsb-1, that is specifically required for meiotic DSB formation in the nematode Caenorhabditis elegans. DSB-1 localizes to chromosomes during early meiotic prophase, coincident with the timing of DSB formation...
  4. Hunter S, Finnegan E, Zisoulis D, Lovci M, Melnik Martinez K, Yeo G, et al. Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003353 pubmed publisher
    ..Loss of let-7 activity causes abnormal development in Caenorhabditis elegans and unchecked cellular proliferation in human cells, which contributes to tumorigenesis...
  5. Liu B, Du H, Rutkowski R, Gartner A, Wang X. LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science. 2012;337:351-4 pubmed publisher
    ..Here, we identified the Caenorhabditis elegans lysosomal lysine/arginine transporter LAAT-1...
  6. Andersen E, Bloom J, Gerke J, Kruglyak L. A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology. PLoS Genet. 2014;10:e1004156 pubmed publisher
    ..We identified a quantitative trait locus in Caenorhabditis elegans that affects three seemingly unrelated phenotypic traits: lifetime fecundity, adult body size, and ..
  7. Smith E, Martinez Velazquez L, Ringstad N. A chemoreceptor that detects molecular carbon dioxide. J Biol Chem. 2013;288:37071-81 pubmed publisher
    ..We have determined the chemical tuning of isolated CO2 chemosensory BAG neurons of the nematode Caenorhabditis elegans. We show that BAG neurons are principally tuned to detect molecular CO2, although they can be activated by ..
  8. Jovanovic M, Reiter L, Clark A, Weiss M, Picotti P, Rehrauer H, et al. RIP-chip-SRM--a new combinatorial large-scale approach identifies a set of translationally regulated bantam/miR-58 targets in C. elegans. Genome Res. 2012;22:1360-71 pubmed publisher
    ..via selected reaction monitoring), to identify de novo high-confidence miRNA targets in the nematode Caenorhabditis elegans. We used differential RIP-chip analysis of miRNA-induced silencing complexes from wild-type and miRNA ..
  9. Weick E, Sarkies P, Silva N, Chen R, Moss S, Cording A, et al. PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. elegans. Genes Dev. 2014;28:783-96 pubmed publisher
    ..Most Caenorhabditis elegans piRNAs are transcribed from two genomic clusters that likely contain thousands of individual transcription ..
  10. Fievet B, Rodriguez J, Naganathan S, Lee C, Zeiser E, Ishidate T, et al. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy. Nat Cell Biol. 2013;15:103-12 pubmed publisher
    ..We performed RNAi screens for 17 Caenorhabditis elegans cell polarity mutants, generating the most comprehensive polarity network in a metazoan, connecting 184 ..
  11. Tullet J, Araiz C, Sanders M, Au C, Benedetto A, Papatheodorou I, et al. DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 2014;10:e1004109 pubmed publisher
    The DAF-16/FoxO transcription factor controls growth, metabolism and aging in Caenorhabditis elegans. The large number of genes that it regulates has been an obstacle to understanding its function...
  12. Lamelza P, Bhalla N. Histone methyltransferases MES-4 and MET-1 promote meiotic checkpoint activation in Caenorhabditis elegans. PLoS Genet. 2012;8:e1003089 pubmed publisher
    ..In Caenorhabditis elegans, unsynapsed chromosomes also activate a meiotic checkpoint that monitors synapsis...
  13. Manil Ségalen M, Lefebvre C, Jenzer C, Trichet M, Boulogne C, Satiat Jeunemaitre B, et al. The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39. Dev Cell. 2014;28:43-55 pubmed publisher
    ..Using Caenorhabditis elegans, we investigated the functions of the GABARAP and the LC3 homologs, LGG-1 and LGG-2, in autophagosome ..
  14. Sun J, Liu Y, Aballay A. Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation. EMBO Rep. 2012;13:855-60 pubmed publisher
    ..Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation. ..
  15. Zugasti O, Bose N, Squiban B, Belougne J, Kurz C, Schroeder F, et al. Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans. Nat Immunol. 2014;15:833-8 pubmed publisher
    ..The elicitors of immune responses in the nematode Caenorhabditis elegans are unclear...
  16. Boulias K, Horvitz H. The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO. Cell Metab. 2012;15:439-50 pubmed publisher
    The life span of Caenorhabditis elegans is controlled by signaling between the germline and the soma. Germ cell removal extends life span by triggering the activation of the DAF-16/FOXO transcription factor in the intestine...
  17. Tecle E, Díaz Balzac C, B low H. Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans. G3 (Bethesda). 2013;3:541-52 pubmed publisher
    ..By examining patterning of the Caenorhabditis elegans nervous system in loss of function mutants of the two 3-O-sulfotransferases, hst-3.1 and hst-3...
  18. Zinovyeva A, Bouasker S, Simard M, Hammell C, Ambros V. Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression. PLoS Genet. 2014;10:e1004286 pubmed publisher
    ..ALG-1 is one of two Caenorhabditis elegans Argonautes (ALG-1 and ALG-2) that together are essential for microRNA biogenesis and function...
  19. Joyce P, Satija R, Chen M, Kuwabara P. The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration. PLoS Genet. 2012;8:e1002602 pubmed publisher
    ..Here, we take advantage of the model organism Caenorhabditis elegans, which expresses only atypical calpains, to extend our knowledge of the phylogenetic evolution and ..
  20. Roh H, Collier S, Deshmukh K, Guthrie J, Robertson J, Kornfeld K. ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis. PLoS Genet. 2013;9:e1003522 pubmed publisher
    ..a comprehensive list of 14 predicted Cation Diffusion Facilitator (CDF) family zinc transporters in Caenorhabditis elegans and demonstrated that zinc is excreted from intestinal cells by one of these CDF proteins, TTM-1B...
  21. O Rourke E, Ruvkun G. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2013;15:668-76 pubmed publisher
    ..lysosomal lipolysis and autophagy to nutrient availability and controlling fat storage and ageing in Caenorhabditis elegans. Transcriptional coupling of lysosomal lipolysis and autophagy to nutrients is also observed in mammals...
  22. Leinwand S, Chalasani S. Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans. Nat Neurosci. 2013;16:1461-7 pubmed publisher
    ..Our results indicate that sensory context and neuropeptide signaling modify neural networks and suggest general mechanisms for generating flexible behavioral outputs by modulating neural circuit composition. ..
  23. Kim S, Shin E, Hahm J, Park P, Hwang J, Paik Y. PDHK-2 deficiency is associated with attenuation of lipase-mediated fat consumption for the increased survival of Caenorhabditis elegans dauers. PLoS ONE. 2012;7:e41755 pubmed publisher
    In Caenorhabditis elegans, slow fat consumption has been suggested to contribute to the extension of the survival rate during nutritionally adverse conditions...
  24. Kimata T, Tanizawa Y, Can Y, Ikeda S, Kuhara A, Mori I. Synaptic polarity depends on phosphatidylinositol signaling regulated by myo-inositol monophosphatase in Caenorhabditis elegans. Genetics. 2012;191:509-21 pubmed publisher
    ..myo-inositol monophosphatase (IMPase) is essential for polarized localization of synaptic molecules in Caenorhabditis elegans and can be inhibited by lithium, a drug for bipolar disorder...
  25. Visvikis O, Ihuegbu N, Labed S, Luhachack L, Alves A, Wollenberg A, et al. Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. Immunity. 2014;40:896-909 pubmed publisher
    ..By using an unbiased approach in the model Caenorhabditis elegans, we discovered that HLH-30 (known as TFEB in mammals) is a key transcription factor for host defense...
  26. Hermann G, Scavarda E, Weis A, Saxton D, Thomas L, Salesky R, et al. C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules. PLoS ONE. 2012;7:e43043 pubmed publisher
    ..Our work opens up the opportunity to address the function of this poorly understood complex in cell and organismal physiology using the genetic approaches available in C. elegans. ..
  27. Huang W, Li Z, Xu Y, Wang W, Zhou M, Zhang P, et al. PKG and NHR-49 signalling co-ordinately regulate short-term fasting-induced lysosomal lipid accumulation in C. elegans. Biochem J. 2014;461:509-20 pubmed publisher
    ..In Caenorhabditis elegans fasting induces the lysosomal compartment to expand...
  28. Butler J, Mishur R, Bhaskaran S, Rea S. A metabolic signature for long life in the Caenorhabditis elegans Mit mutants. Aging Cell. 2013;12:130-8 pubmed publisher
    ..Mit mutations that disrupt function of the mitochondrial electron transport chain can, inexplicably, prolong Caenorhabditis elegans lifespan...
  29. Tilleman L, De Henau S, Pauwels M, Nagy N, Pintelon I, Braeckman B, et al. An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans. PLoS ONE. 2012;7:e48768 pubmed publisher
    ..Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions...
  30. Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, et al. Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. J Cell Biol. 2012;197:27-35 pubmed publisher
    ..In this paper, we develop live-cell imaging techniques to study apoptotic cell clearance in the Caenorhabditis elegans Q neuroblast lineage...
  31. Peel N, Dougherty M, Goeres J, Liu Y, O Connell K. The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels. J Cell Sci. 2012;125:3535-44 pubmed
    ..Co-depletion of LIN-23 and SEL-10 suggests these proteins function cooperatively. Because SEL-10 is the homolog of human FBW7, which is frequently mutated in cancer, our findings have implications for understanding tumorigenesis...
  32. Labrador L, Barroso C, Lightfoot J, M ller Reichert T, Flibotte S, Taylor J, et al. Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis. PLoS Genet. 2013;9:e1003497 pubmed publisher
  33. Lettman M, Wong Y, Viscardi V, Niessen S, Chen S, Shiau A, et al. Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly. Dev Cell. 2013;25:284-98 pubmed publisher
    ..We propose that ZYG-1 binding to the SAS-6 coiled coil recruits the SAS-6-SAS-5 complex to the mother centriole, where a ZYG-1 kinase activity-dependent step, whose target is unlikely to be SAS-6, triggers cartwheel assembly. ..
  34. Yuan Y, Kadiyala C, Ching T, Hakimi P, Saha S, Xu H, et al. Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. J Biol Chem. 2012;287:31414-26 pubmed publisher
    ..metabolic quantification, and life span analysis was used to determine how CR, which occurs in the Caenorhabditis elegans eat-2 mutants, modifies energy metabolism of the worm, and whether the observed modifications contribute ..
  35. Stawicki T, Takayanagi Kiya S, Zhou K, Jin Y. Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans. PLoS Genet. 2013;9:e1003472 pubmed publisher
    ..We previously reported a Caenorhabditis elegans mutant, acr-2(gf), that displays spontaneous convulsions as the result of a gain-of-function mutation in a ..
  36. Huang C, Chen J, Wu S, Tan C, Tzeng R, Lu P, et al. C. elegans EIF-3.K promotes programmed cell death through CED-3 caspase. PLoS ONE. 2012;7:e36584 pubmed publisher
    ..K. Because human eIF3k was able to partially substitute for C. elegans eif-3.K in the promotion of cell death, this WH domain-dependent EIF-3.K-mediated cell death process has potentially been conserved throughout evolution. ..
  37. Oldenbroek M, Robertson S, Guven Ozkan T, Spike C, Greenstein D, Lin R. Regulation of maternal Wnt mRNA translation in C. elegans embryos. Development. 2013;140:4614-23 pubmed publisher
    ..We propose that the 3'UTR of maternal mRNAs contains a combinatorial code that determines the topography of associated RBPs, integrating positive and negative translational inputs. ..
  38. De Vaux V, Pfefferli C, Passannante M, Belhaj K, von Essen A, Sprecher S, et al. The Caenorhabditis elegans LET-418/Mi2 plays a conserved role in lifespan regulation. Aging Cell. 2013;12:1012-20 pubmed publisher
  39. Lee J, Kim C, Kim J, Park C. DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state. Gene. 2013;524:373-6 pubmed publisher
    b>Caenorhabditis elegans DJR-1.2, a homolog of human DJ-1, has recently been demonstrated to be a novel glyoxalase and protects worms against glyoxals. Here, we report that expression of DJR-1...
  40. Pérez Vargas J, Krey T, Valansi C, Avinoam O, Haouz A, Jamin M, et al. Structural basis of eukaryotic cell-cell fusion. Cell. 2014;157:407-419 pubmed publisher
  41. Moribe H, Konakawa R, Koga D, Ushiki T, Nakamura K, Mekada E. Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002957 pubmed publisher
    ..In contrast to other NOX isozymes, the regulatory mechanisms of DUOX activity are less understood. Using Caenorhabditis elegans as a model, we demonstrate that the tetraspanin protein is required for induction of the DUOX signaling ..
  42. Lee E, Strange K. GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling. Am J Physiol Cell Physiol. 2012;303:C1269-77 pubmed publisher
    ..Increased gpdh-1 transcription is required for accumulation of the organic osmolyte glycerol and survival of Caenorhabditis elegans during hypertonic stress...
  43. Legendre J, Campbell Z, Kroll Conner P, Anderson P, Kimble J, Wickens M. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. J Biol Chem. 2013;288:2532-45 pubmed publisher
    ..We report analysis of Staufen in Caenorhabditis elegans, which we have designated STAU-1...
  44. Robida Stubbs S, Glover Cutter K, Lamming D, Mizunuma M, Narasimhan S, Neumann Haefelin E, et al. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 2012;15:713-24 pubmed publisher
    ..We conclude that modulation of SKN-1/Nrf and DAF-16/FoxO may be generally important in the effects of TOR signaling in vivo and that these transcription factors mediate an opposing relationship between growth signals and longevity. ..
  45. Wollam J, Magner D, Magomedova L, Rass E, Shen Y, Rottiers V, et al. A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. PLoS Biol. 2012;10:e1001305 pubmed publisher
    ..elegans bile acid biosynthetic pathways reveals the possibility of novel ligands as well as striking biochemical conservation to other animals, which could illuminate new targets for manipulating longevity in metazoans. ..
  46. Hsieh H, Hsu T, Jiang H, Wu Y. Integrin ? PAT-2/CDC-42 signaling is required for muscle-mediated clearance of apoptotic cells in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002663 pubmed publisher
    ..Here, we characterize a novel cell corpse engulfment pathway mediated by the integrin ? subunit PAT-2 in Caenorhabditis elegans and show that it specifically functions in muscle-mediated engulfment during embryogenesis...
  47. Cheerambathur D, Gassmann R, Cook B, Oegema K, Desai A. Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation. Science. 2013;342:1239-42 pubmed publisher
    ..Here, we used the Caenorhabditis elegans embryo as a model system to examine the crosstalk between two kinetochore protein complexes implicated in ..
  48. Onitake A, Yamanaka K, Esaki M, Ogura T. Caenorhabditis elegans fidgetin homolog FIGL-1, a nuclear-localized AAA ATPase, binds to SUMO. J Struct Biol. 2012;179:143-51 pubmed publisher
    ..FIGL-1, a Caenorhabditis elegans homolog of mammalian fidgetin, is localized in the nucleus...
  49. Billi A, Alessi A, Khivansara V, Han T, Freeberg M, Mitani S, et al. The Caenorhabditis elegans HEN1 ortholog, HENN-1, methylates and stabilizes select subclasses of germline small RNAs. PLoS Genet. 2012;8:e1002617 pubmed publisher
    ..In Caenorhabditis elegans, a HEN1 ortholog has not been studied, but there is evidence for methylation of piRNAs and some endogenous ..
  50. Warf M, Shepherd B, Johnson W, Bass B. Effects of ADARs on small RNA processing pathways in C. elegans. Genome Res. 2012;22:1488-98 pubmed publisher
    ..from dsRNA precursors, we performed deep-sequencing, comparing small RNAs from wild-type and ADAR mutant Caenorhabditis elegans. While editing in small RNAs was rare, at least 40% of microRNAs had altered levels in at least one ADAR ..
  51. Cochella L, Hobert O. Embryonic priming of a miRNA locus predetermines postmitotic neuronal left/right asymmetry in C. elegans. Cell. 2012;151:1229-42 pubmed publisher
    ..This study shows how cells can become committed during early developmental stages to execute a specific fate much later in development and provides a conceptual framework for understanding the generation of neuronal diversity. ..
  52. Makyio H, Takeuchi T, Tamura M, Nishiyama K, Takahashi H, Natsugari H, et al. Structural basis of preferential binding of fucose-containing saccharide by the Caenorhabditis elegans galectin LEC-6. Glycobiology. 2013;23:797-805 pubmed publisher
    ..LEC-6, a member of galectins of Caenorhabditis elegans, binds fucose-containing saccharides...
  53. Tepper R, Ashraf J, Kaletsky R, Kleemann G, Murphy C, Bussemaker H. PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell. 2013;154:676-690 pubmed publisher
    ..We observe progressive loss of nuclear PQM-1 with age, explaining declining expression of PQM-1 targets. Together, our data suggest an elegant mechanism for balancing stress response and development. ..
  54. Gomez F, Saiki R, Chin R, Srinivasan C, Clarke C. Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation. Gene. 2012;506:106-16 pubmed publisher
    ..In Caenorhabditis elegans Q biosynthesis involves at least nine steps, including the hydroxylation of the hydroquinone ring by CLK-1 ..
  55. Zisoulis D, Kai Z, Chang R, Pasquinelli A. Autoregulation of microRNA biogenesis by let-7 and Argonaute. Nature. 2012;486:541-4 pubmed publisher
    ..We found that the Argonaute protein in Caenorhabditis elegans, ALG-1, binds to a specific site at the 3? end of let-7 miRNA primary transcripts and promotes downstream ..
  56. Rousakis A, Vlassis A, Vlanti A, Patera S, Thireos G, Syntichaki P. The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans. Aging Cell. 2013;12:742-51 pubmed publisher
    ..Here we established the conserved role of Caenorhabditis elegans GCN-2 under amino acid limitation as a translation initiation factor 2 (eIF2) kinase...
  57. Yang X, Fan J, Ishchenko A, Patel D, Saparbaev M, Ramotar D. Functional characterization of the Caenorhabditis elegans DNA repair enzyme APN-1. DNA Repair (Amst). 2012;11:811-22 pubmed publisher
    b>Caenorhabditis elegans possesses two distinct DNA repair enzymes EXO-3 and APN-1 that have been identified by cross-specie complementation analysis of the Saccharomyces cerevisiae apn1?apn2?tpp1? triple mutant deficient in the ability to ..
  58. Chen D, Jian Y, Liu X, Zhang Y, Liang J, Qi X, et al. Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003517 pubmed publisher
    ..Here, we report the essential role of clathrin and AP2 in phagocytosis of apoptotic cells. In Caenorhabditis elegans, depletion of the clathrin heavy chain CHC-1 and individual components of AP2 led to a significant ..
  59. Chew Y, Fan X, Götz J, Nicholas H. PTL-1 regulates neuronal integrity and lifespan in C. elegans. J Cell Sci. 2013;126:2079-91 pubmed publisher
    Protein with tau-like repeats (PTL-1) is the sole Caenorhabditis elegans homolog of tau and MAP2, which are members of the mammalian family of microtubule-associated proteins (MAPs)...
  60. Hachet V, Busso C, Toya M, Sugimoto A, Askjaer P, G nczy P. The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos. Mol Biol Cell. 2012;23:3111-21 pubmed publisher
    ..We conducted an RNA interference-based modifier screen to identify novel regulators of mitosis in Caenorhabditis elegans embryos...
  61. Ferguson A, Roy S, Kormanik K, Kim Y, Dumas K, Ritov V, et al. TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans. PLoS Genet. 2013;9:e1004020 pubmed publisher
    ..regulator of the dauer decision and modulator of the daf-2 insulin/IGF-1-like (IGFR) signaling pathway in Caenorhabditis elegans. Mutations affecting tatn-1 elevate tyrosine levels in the animal, and enhance the effects of mutations in ..
  62. Edwards S, Yu S, Hoover C, Phillips B, Richmond J, Miller K. An organelle gatekeeper function for Caenorhabditis elegans UNC-16 (JIP3) at the axon initial segment. Genetics. 2013;194:143-61 pubmed publisher
    ..Here we use electron microscopy and quantitative imaging of tagged organelles to show that Caenorhabditis elegans axons lacking UNC-16 (JIP3/Sunday Driver) accumulate Golgi, endosomes, and lysosomes at levels up to 10-..
  63. Goodwin P, Sasaki J, Juo P. Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. J Neurosci. 2012;32:8158-72 pubmed publisher
    ..are required for the polarized distribution of neuropeptide-containing dense-core vesicles (DCVs) in Caenorhabditis elegans cholinergic motor neurons...
  64. Bendesky A, Pitts J, Rockman M, Chen W, Tan M, Kruglyak L, et al. Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. PLoS Genet. 2012;8:e1003157 pubmed publisher
    ..In the nematode Caenorhabditis elegans, aggregation is regulated by environmental context and by two neuromodulatory pathways, one dependent on ..
  65. Sasaki A, Nakae I, Nagasawa M, Hashimoto K, Abe F, Saito K, et al. Arl8/ARL-8 functions in apoptotic cell removal by mediating phagolysosome formation in Caenorhabditis elegans. Mol Biol Cell. 2013;24:1584-92 pubmed publisher
    ..Here we show that the Caenorhabditis elegans Arf-like small GTPase Arl8 (ARL-8) is involved in phagolysosome formation and is required for the ..
  66. Sarov M, Murray J, Schanze K, Pozniakovski A, Niu W, Angermann K, et al. A genome-scale resource for in vivo tag-based protein function exploration in C. elegans. Cell. 2012;150:855-66 pubmed publisher
    ..a genome-scale transgenic platform for in vivo expression of fluorescent- and affinity-tagged proteins in Caenorhabditis elegans under endogenous cis regulatory control...
  67. Zhang X, Zhang Y. DBL-1, a TGF-?, is essential for Caenorhabditis elegans aversive olfactory learning. Proc Natl Acad Sci U S A. 2012;109:17081-6 pubmed publisher
    ..However, the underlying mechanisms are not well understood. Here we report that DBL-1, a Caenorhabditis elegans TGF-? homolog known to control body morphology and immunity, is essential for aversive olfactory learning ..
  68. Pittman K, Skop A. Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans. Cytoskeleton (Hoboken). 2012;69:826-39 pubmed publisher
    ..Our data indicate that the PAR proteins are involved in the events that occur during cytokinesis and may play a role in promoting the membrane trafficking and remodeling events that occur during this time...
  69. Van Nostrand E, S nchez Blanco A, Wu B, Nguyen A, Kim S. Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003325 pubmed publisher
    ..These results illustrate how unc-62 regulation of intestinal gene expression is responsible for limiting lifespan during the normal aging process...
  70. Shen Q, He B, Lu N, Conradt B, Grant B, Zhou Z. Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans. Development. 2013;140:3230-43 pubmed publisher
    ..endocytosis, and its adaptor epsin (EPN-1) play crucial roles in removing apoptotic cells in Caenorhabditis elegans. Inactivating epn-1 or chc-1 disrupts engulfment by impairing actin polymerization...
  71. Brockie P, Jensen M, Mellem J, Jensen E, Yamasaki T, Wang R, et al. Cornichons control ER export of AMPA receptors to regulate synaptic excitability. Neuron. 2013;80:129-42 pubmed publisher
    ..In reconstitution studies, we provide support for an evolutionarily conserved role for cornichons in regulating the export of vertebrate and invertebrate AMPARs. ..
  72. Chen Y, Mapes J, Lee E, Skeen Gaar R, Xue D. Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization. Nat Commun. 2013;4:2726 pubmed publisher
    ..It is poorly understood how PS exposure is activated in apoptotic cells. Here we report that CED-8, a Caenorhabditis elegans protein implicated in controlling the kinetics of apoptosis and a homologue of the XK family proteins, is ..
  73. Saito T, Lui D, Kim H, Meyer K, COLAIACOVO M. Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. PLoS Genet. 2013;9:e1003586 pubmed publisher
    ..differences between these four nucleases regarding their roles in crossover formation and control in the Caenorhabditis elegans germline...
  74. Lapierre L, De Magalhaes Filho C, McQuary P, Chu C, Visvikis O, Chang J, et al. The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun. 2013;4:2267 pubmed publisher
    ..Here we show that the predicted TFEB orthologue HLH-30 regulates autophagy in Caenorhabditis elegans and, in addition, has a key role in lifespan determination...
  75. Kim D, Grün D, van Oudenaarden A. Dampening of expression oscillations by synchronous regulation of a microRNA and its target. Nat Genet. 2013;45:1337-44 pubmed publisher
    ..We find that in the nematode Caenorhabditis elegans approximately 2,000 transcripts undergo expression oscillations synchronized with larval transitions while ..
  76. Dallaire A, Garand C, Paquel E, Mitchell S, De Cabo R, Simard M, et al. Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging. Aging (Albany NY). 2012;4:636-47 pubmed publisher
    ..b>Caenorhabditis elegans (C. elegans) with a nonfunctional wrn-1 DNA helicase also exhibit a shorter life span...
  77. Yang Y, Lee W, Tang X, Wadsworth W. Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity. PLoS ONE. 2014;9:e97258 pubmed publisher
    How extracellular molecules influence the direction of axon guidance is poorly understood. The HSN axon of Caenorhabditis elegans is guided towards a ventral source of secreted UNC-6 (netrin)...
  78. Dalpé G, Zheng H, Brown L, Culotti J. Semaphorin-1 and netrin signal in parallel and permissively to position the male ray 1 sensillum in Caenorhabditis elegans. Genetics. 2012;192:959-71 pubmed publisher
    ..The most anterior ray sensillum (ray 1) in the Caenorhabditis elegans male tail is frequently displaced anterior to its normal position in smp-1/semaphorin-1a and plexin-1/plx-..
  79. Silva García C, Estela Navarro R. The C. elegans TIA-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis. Genesis. 2013;51:690-707 pubmed publisher
    In Caenorhabditis elegans, physiological germ cell apoptosis eliminates more than half of the cells in the hermaphrodite gonad to support gamete quality and germline homeostasis by a still unidentified mechanism...
  80. Kniazeva M, Shen H, Euler T, Wang C, Han M. Regulation of maternal phospholipid composition and IP(3)-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans. Genes Dev. 2012;26:554-66 pubmed publisher
    ..ACS-1 on branched chain FA C17ISO impacts maternal lipid content, signal transduction, and development in Caenorhabditis elegans embryos...
  81. Gaydos L, Rechtsteiner A, Egelhofer T, Carroll C, Strome S. Antagonism between MES-4 and Polycomb repressive complex 2 promotes appropriate gene expression in C. elegans germ cells. Cell Rep. 2012;2:1169-77 pubmed publisher
    The Caenorhabditis elegans MES proteins are key chromatin regulators of the germline. MES-2, MES-3, and MES-6 form the C. elegans Polycomb repressive complex 2 and generate repressive H3K27me3...
  82. Petrash H, Philbrook A, Haburcak M, Barbagallo B, Francis M. ACR-12 ionotropic acetylcholine receptor complexes regulate inhibitory motor neuron activity in Caenorhabditis elegans. J Neurosci. 2013;33:5524-32 pubmed publisher
    ..types contributes to the coordinated activity of excitatory and inhibitory motor neurons in the nematode Caenorhabditis elegans. We show that excitatory and inhibitory motor neurons express distinct populations of ionotropic ..
  83. Skorobogata O, Rocheleau C. RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans. PLoS ONE. 2012;7:e36489 pubmed publisher
    ..Here we used Caenorhabditis elegans vulva cell fate induction, a paradigm for genetic analysis of EGFR/Receptor Tyrosine Kinase (RTK) ..
  84. Nousch M, Techritz N, Hampel D, Millonigg S, Eckmann C. The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans. J Cell Sci. 2013;126:4274-85 pubmed publisher
    ..In this study, we identify and characterize all known deadenylases of Caenorhabditis elegans, and identify the germ line as tissue that depends strongly on deadenylase activity...
  85. Hu Z, Hom S, Kudze T, Tong X, Choi S, Aramuni G, et al. Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans. Science. 2012;337:980-4 pubmed publisher
    ..Here, we found that Caenorhabditis elegans neurexin (NRX-1) and neuroligin (NLG-1) mediated a retrograde synaptic signal that inhibited ..
  86. Lee H, Kubo T, Kono N, Kage Nakadai E, Gengyo Ando K, Mitani S, et al. Depletion of mboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling in Caenorhabditis elegans. Genes Cells. 2012;17:748-57 pubmed publisher
    ..However, the biological significance of PUFA-containing PI remains unknown. We previously identified Caenorhabditis elegans (C. elegans) mboa-7 as an acyltransferase that incorporates PUFAs into the sn-2 position of PI...
  87. Anderson C, Zhou S, Sawin E, Horvitz H, HURWITZ M. SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function. PLoS Genet. 2012;8:e1003115 pubmed publisher
    The engulfment of apoptotic cells is required for normal metazoan development and tissue remodeling. In Caenorhabditis elegans, two parallel and partially redundant conserved pathways act in cell-corpse engulfment...
  88. Eberhard R, Stergiou L, Hofmann E, Hofmann J, Haenni S, Teo Y, et al. Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003943 pubmed publisher
    ..Ribosome synthesis and growth-factor signalling are perturbed in many cancer cells; such an interplay between basic cellular processes and signalling might be critical for how tumours evolve or respond to treatment. ..
  89. Hattori A, Mizuno T, Akamatsu M, Hisamoto N, Matsumoto K. The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex. PLoS Genet. 2013;9:e1003315 pubmed publisher
    ..In Caenorhabditis elegans, the KGB-1 JNK signaling pathway regulates the response to heavy metal stress...
  90. Haag A, Gutierrez P, Bühler A, Walser M, Yang Q, Langouet M, et al. An in vivo EGF receptor localization screen in C. elegans Identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling. PLoS Genet. 2014;10:e1004341 pubmed publisher
    ..The regulation of receptor localization thus serves to fine-tune the temporal activation of intracellular signaling pathways. ..
  91. Jose A, Kim Y, Leal Ekman S, Hunter C. Conserved tyrosine kinase promotes the import of silencing RNA into Caenorhabditis elegans cells. Proc Natl Acad Sci U S A. 2012;109:14520-5 pubmed publisher
    RNA silencing in Caenorhabditis elegans is transmitted between cells by the transport of double-stranded RNA (dsRNA). The efficiency of such transmission, however, depends on both the cell type and the environment...
  92. Kuroyanagi H, Watanabe Y, Hagiwara M. CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003337 pubmed publisher
    ..Here we provide models of the regulation of two sets of mutually exclusive exons, 4a-4c and 7a-7b, of the Caenorhabditis elegans uncoordinated (unc)-32 gene, encoding the a subunit of V0 complex of vacuolar-type H(+)-ATPases...