Drosophila pseudoobscura pseudoobscura

Summary

Alias:

Top Publications

  1. Ludwig M, Bergman C, Patel N, Kreitman M. Evidence for stabilizing selection in a eukaryotic enhancer element. Nature. 2000;403:564-7 pubmed
    ..Sequence differences between species have functional consequences, therefore, but they are masked by other co-evolved differences. On the basis of these results, we present a model for the evolution of eukaryotic regulatory sequences. ..
  2. Ludwig M, Palsson A, Alekseeva E, Bergman C, Nathan J, Kreitman M. Functional evolution of a cis-regulatory module. PLoS Biol. 2005;3:e93 pubmed
    ..Our findings have implications for understanding enhancer structure-function, mechanisms of speciation and computational identification of regulatory modules. ..
  3. Schaeffer S, Anderson W. Mechanisms of genetic exchange within the chromosomal inversions of Drosophila pseudoobscura. Genetics. 2005;171:1729-39 pubmed
    ..At least one case where selection rather than proximity to an inversion breakpoint is responsible for reduction in polymorphism was identified. ..
  4. Ronshaugen M, Biemar F, Piel J, Levine M, Lai E. The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings. Genes Dev. 2005;19:2947-52 pubmed
    ..These findings provide the first evidence for a noncoding homeotic gene and raise the possibility that other such genes occur within the Bithorax complex. We also discuss the regulation of mir-iab-4 expression during development. ..
  5. Hudson S, Garrett M, Carlson J, Micklem G, Celniker S, Goldstein E, et al. Phylogenetic and genomewide analyses suggest a functional relationship between kayak, the Drosophila fos homolog, and fig, a predicted protein phosphatase 2c nested within a kayak intron. Genetics. 2007;177:1349-61 pubmed
    ..Overall, our phylogenetic and genomewide analyses suggest that the nested arrangement of kay and fig may be due to a functional relationship between them. ..
  6. Pepling M, Gergen J. Conservation and function of the transcriptional regulatory protein Runt. Proc Natl Acad Sci U S A. 1995;92:9087-91 pubmed
    ..Ectopic expression experiments indicated that proteins containing the AML1 Runt domain function in Drosophila embryos and that sequences outside of this domain are important in vivo. ..
  7. Vermaak D, Hayden H, Henikoff S. Centromere targeting element within the histone fold domain of Cid. Mol Cell Biol. 2002;22:7553-61 pubmed
    ..We suggest that the process of deposition of (Cid.H4)2 tetramers allows for discriminating contacts to be made between loop I and DNA, providing the specificity needed for targeting. ..
  8. Goldman A, Van der Goes van Naters W, Lessing D, Warr C, Carlson J. Coexpression of two functional odor receptors in one neuron. Neuron. 2005;45:661-6 pubmed
    ..Most importantly, their coexpression has been conserved for >45 million years. Expression of multiple odor receptors in a cell provides an additional degree of freedom for odor coding. ..
  9. Glazov E, Pheasant M, McGraw E, Bejerano G, Mattick J. Ultraconserved elements in insect genomes: a highly conserved intronic sequence implicated in the control of homothorax mRNA splicing. Genome Res. 2005;15:800-8 pubmed
  10. Ray A, van Naters W, Shiraiwa T, Carlson J. Mechanisms of odor receptor gene choice in Drosophila. Neuron. 2007;53:353-69 pubmed
    ..We show that receptor gene choice in Drosophila also depends on a combinatorial code of transcription factors to generate the receptor-to-neuron map. ..

Detail Information

Publications137 found, 100 shown here

  1. Ludwig M, Bergman C, Patel N, Kreitman M. Evidence for stabilizing selection in a eukaryotic enhancer element. Nature. 2000;403:564-7 pubmed
    ..Sequence differences between species have functional consequences, therefore, but they are masked by other co-evolved differences. On the basis of these results, we present a model for the evolution of eukaryotic regulatory sequences. ..
  2. Ludwig M, Palsson A, Alekseeva E, Bergman C, Nathan J, Kreitman M. Functional evolution of a cis-regulatory module. PLoS Biol. 2005;3:e93 pubmed
    ..Our findings have implications for understanding enhancer structure-function, mechanisms of speciation and computational identification of regulatory modules. ..
  3. Schaeffer S, Anderson W. Mechanisms of genetic exchange within the chromosomal inversions of Drosophila pseudoobscura. Genetics. 2005;171:1729-39 pubmed
    ..At least one case where selection rather than proximity to an inversion breakpoint is responsible for reduction in polymorphism was identified. ..
  4. Ronshaugen M, Biemar F, Piel J, Levine M, Lai E. The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings. Genes Dev. 2005;19:2947-52 pubmed
    ..These findings provide the first evidence for a noncoding homeotic gene and raise the possibility that other such genes occur within the Bithorax complex. We also discuss the regulation of mir-iab-4 expression during development. ..
  5. Hudson S, Garrett M, Carlson J, Micklem G, Celniker S, Goldstein E, et al. Phylogenetic and genomewide analyses suggest a functional relationship between kayak, the Drosophila fos homolog, and fig, a predicted protein phosphatase 2c nested within a kayak intron. Genetics. 2007;177:1349-61 pubmed
    ..Overall, our phylogenetic and genomewide analyses suggest that the nested arrangement of kay and fig may be due to a functional relationship between them. ..
  6. Pepling M, Gergen J. Conservation and function of the transcriptional regulatory protein Runt. Proc Natl Acad Sci U S A. 1995;92:9087-91 pubmed
    ..Ectopic expression experiments indicated that proteins containing the AML1 Runt domain function in Drosophila embryos and that sequences outside of this domain are important in vivo. ..
  7. Vermaak D, Hayden H, Henikoff S. Centromere targeting element within the histone fold domain of Cid. Mol Cell Biol. 2002;22:7553-61 pubmed
    ..We suggest that the process of deposition of (Cid.H4)2 tetramers allows for discriminating contacts to be made between loop I and DNA, providing the specificity needed for targeting. ..
  8. Goldman A, Van der Goes van Naters W, Lessing D, Warr C, Carlson J. Coexpression of two functional odor receptors in one neuron. Neuron. 2005;45:661-6 pubmed
    ..Most importantly, their coexpression has been conserved for >45 million years. Expression of multiple odor receptors in a cell provides an additional degree of freedom for odor coding. ..
  9. Glazov E, Pheasant M, McGraw E, Bejerano G, Mattick J. Ultraconserved elements in insect genomes: a highly conserved intronic sequence implicated in the control of homothorax mRNA splicing. Genome Res. 2005;15:800-8 pubmed
  10. Ray A, van Naters W, Shiraiwa T, Carlson J. Mechanisms of odor receptor gene choice in Drosophila. Neuron. 2007;53:353-69 pubmed
    ..We show that receptor gene choice in Drosophila also depends on a combinatorial code of transcription factors to generate the receptor-to-neuron map. ..
  11. Swanson C, Evans N, Barolo S. Structural rules and complex regulatory circuitry constrain expression of a Notch- and EGFR-regulated eye enhancer. Dev Cell. 2010;18:359-70 pubmed publisher
  12. Andrioli L, Vasisht V, Theodosopoulou E, Oberstein A, Small S. Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms. Development. 2002;129:4931-40 pubmed
    ..These results suggest a common mechanism for preventing anterior activation of three different eve enhancers. ..
  13. Schaeffer S. Molecular population genetics of sequence length diversity in the Adh region of Drosophila pseudoobscura. Genet Res. 2002;80:163-75 pubmed
    ..Genome rearrangement and size-dependent intron evolution are proposed as mechanisms that limit runaway intron expansion. ..
  14. Costas J, Casares F, Vieira J. Turnover of binding sites for transcription factors involved in early Drosophila development. Gene. 2003;310:215-20 pubmed
    ..Finally, we detected a significant decrease in mean PWM scores for the D. virilis binding sites in the case of Hunchback. Possible explanations for this fact are discussed. ..
  15. Graveley B. Mutually exclusive splicing of the insect Dscam pre-mRNA directed by competing intronic RNA secondary structures. Cell. 2005;123:65-73 pubmed
  16. Jeong S, Rokas A, Carroll S. Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolution. Cell. 2006;125:1387-99 pubmed
    ..These results demonstrate how Hox regulation of traits and target genes is gained and lost at the species level and have general implications for the evolution of body form at higher taxonomic levels. ..
  17. Brideau N, Flores H, Wang J, Maheshwari S, Wang X, Barbash D. Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila. Science. 2006;314:1292-5 pubmed
    ..Rapidly evolving heterochromatic DNA sequences may be driving the evolution of this incompatibility gene. ..
  18. Fowlkes C, Eckenrode K, Bragdon M, Meyer M, Wunderlich Z, Simirenko L, et al. A conserved developmental patterning network produces quantitatively different output in multiple species of Drosophila. PLoS Genet. 2011;7:e1002346 pubmed publisher
    ..Our results emphasize that transcriptional networks can diverge over short evolutionary timescales and that even small changes can lead to distinct output in terms of the placement and number of equivalent cells. ..
  19. Ludwig M, Patel N, Kreitman M. Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change. Development. 1998;125:949-58 pubmed
    ..This view allows for a slow but continual turnover of functionally important changes in the stripe 2 enhancer. ..
  20. Hamblin M, Aquadro C. DNA sequence variation and the recombinational landscape in Drosophila pseudoobscura: a study of the second chromosome. Genetics. 1999;153:859-69 pubmed
    ..pseudoobscura may have experienced a rapid population expansion in the recent past or, alternatively, that slightly deleterious mutations constitute an important component of standing variation in this species. ..
  21. Schaeffer S, Goetting Minesky M, Kovacevic M, Peoples J, Graybill J, Miller J, et al. Evolutionary genomics of inversions in Drosophila pseudoobscura: evidence for epistasis. Proc Natl Acad Sci U S A. 2003;100:8319-24 pubmed
    ..pseudoobscura have emerged as suppressors of recombination to maintain positive epistatic relationships among loci within gene arrangements that developed as the species adapted to a heterogeneous environment. ..
  22. Barbash D, Awadalla P, Tarone A. Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus. PLoS Biol. 2004;2:e142 pubmed
    ..Our findings suggest that multiple substitutions driven by natural selection may be a general phenomenon required to generate hybrid incompatibility alleles. ..
  23. Gompel N, Prud homme B, Wittkopp P, Kassner V, Carroll S. Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila. Nature. 2005;433:481-7 pubmed
  24. Rebeiz M, Stone T, Posakony J. An ancient transcriptional regulatory linkage. Dev Biol. 2005;281:299-308 pubmed
    ..We suggest that the systematic identification of such ancient and conserved connections will be a powerful means of uncovering the primordial functions of transcription factors and signaling systems. ..
  25. Thorne N, Amrein H. Atypical expression of Drosophila gustatory receptor genes in sensory and central neurons. J Comp Neurol. 2008;506:548-68 pubmed
    ..It is also possible that the Gr28 genes have chemosensory roles in the detection of internal ligands. ..
  26. Noor M, Schug M, Aquadro C. Microsatellite variation in populations of Drosophila pseudoobscura and Drosophila persimilis. Genet Res. 2000;75:25-35 pubmed
    ..pseudoobscura. Finally, our preliminary recombinational mapping of 24 of these microsatellites suggests that the total recombinational genome size may be larger than previously inferred using morphological mutant markers. ..
  27. Crocker J, Tamori Y, Erives A. Evolution acts on enhancer organization to fine-tune gradient threshold readouts. PLoS Biol. 2008;6:e263 pubmed publisher
    ..Our study demonstrates that equivalence classes of CRMs are powerful tools for detecting lineage-specific adaptations by gene regulatory sequences. ..
  28. Swanson C, Schwimmer D, Barolo S. Rapid evolutionary rewiring of a structurally constrained eye enhancer. Curr Biol. 2011;21:1186-96 pubmed publisher
    ..Our findings demonstrate that even a severely constrained cis-regulatory sequence can be significantly rewired over a short evolutionary timescale. ..
  29. Yasuhara J, DeCrease C, Wakimoto B. Evolution of heterochromatic genes of Drosophila. Proc Natl Acad Sci U S A. 2005;102:10958-63 pubmed
    ..We conclude that heterochromatin-dependent regulation requires specialized enhancers or higher-order interactions and propose a facilitating role for transposable elements...
  30. Hallikas O, Palin K, Sinjushina N, Rautiainen R, Partanen J, Ukkonen E, et al. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell. 2006;124:47-59 pubmed
  31. Russo C, Takezaki N, Nei M. Molecular phylogeny and divergence times of drosophilid species. Mol Biol Evol. 1995;12:391-404 pubmed publisher
    ..melanogaster groups apparently diverged about 25 Mya. Many of the D. repleta group species studied here have two functional Adh genes (Adh-1 and Adh-2), and these duplicated genes can be explained by two duplication events...
  32. Wang R, Wakeley J, Hey J. Gene flow and natural selection in the origin of Drosophila pseudoobscura and close relatives. Genetics. 1997;147:1091-106 pubmed
    ..This family of models includes some sympatric and parapatric speciation models, as well as models of secondary contact and subsequent reinforcement of sexual isolation...
  33. Malik H, Vermaak D, Henikoff S. Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone. Proc Natl Acad Sci U S A. 2002;99:1449-54 pubmed publisher
    ..The recurrent evolution of these motifs in CenH3 suggests a packaging function for the N-terminal tail, which results in a unique chromatin organization at the primary constriction, the cytological marker of centromeres...
  34. Hare E, Peterson B, Iyer V, Meier R, Eisen M. Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation. PLoS Genet. 2008;4:e1000106 pubmed publisher
    ..Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function...
  35. Yasukawa J, Tomioka S, Aigaki T, Matsuo T. Evolution of expression patterns of two odorant-binding protein genes, Obp57d and Obp57e, in Drosophila. Gene. 2010;467:25-34 pubmed publisher
    ..This result shows that, as well as their ORF sequences, the expression patterns of Obp57d and Obp57e have diverged substantially between closely related Drosophila species...
  36. Schaeffer S, Miller E. Estimates of gene flow in Drosophila pseudoobscura determined from nucleotide sequence analysis of the alcohol dehydrogenase region. Genetics. 1992;132:471-80 pubmed
    ..pseudoobscura. The nucleotide diversity data is consistent with direct and indirect measures of gene flow that show extensive dispersal between populations of D. pseudoobscura...
  37. Babcock C, Anderson W. Molecular evolution of the Sex-Ratio inversion complex in Drosophila pseudoobscura: analysis of the Esterase-5 gene region. Mol Biol Evol. 1996;13:297-308 pubmed publisher
    ..persimilis and that both the Standard and Sex-Ratio chromosomes of D. persimilis were derived from the Standard chromosome of D. pseudoobscura after the inversion events that isolated the D. pseudoobscura Sex-Ratio chromosome...
  38. Machado C, Kliman R, Markert J, Hey J. Inferring the history of speciation from multilocus DNA sequence data: the case of Drosophila pseudoobscura and close relatives. Mol Biol Evol. 2002;19:472-88 pubmed publisher
    ..pseudoobscura and D. persimilis. We show that there is a good correspondence between the genomic regions associated with reproductive isolation and the regions that show little or no evidence of gene flow...
  39. Graveley B, Kaur A, Gunning D, Zipursky S, Rowen L, Clemens J. The organization and evolution of the dipteran and hymenopteran Down syndrome cell adhesion molecule (Dscam) genes. RNA. 2004;10:1499-506 pubmed publisher
    ..In addition, these findings suggest that the expression of a large Dscam repertoire is more important for the development and function of the insect nervous system than the actual sequence of each isoform...
  40. Matsuo T. Rapid evolution of two odorant-binding protein genes, Obp57d and Obp57e, in the Drosophila melanogaster species group. Genetics. 2008;178:1061-72 pubmed publisher
    ..Our analyses demonstrate that these two classes of differences can be distinguished by comparisons of many genomic sequences from closely related species...
  41. Grienenberger A, Merabet S, Manak J, Iltis I, Fabre A, B renger H, et al. Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development. 2003;130:5445-55 pubmed publisher
    ..The signal, acting through Mad and Creb, provides spatial information that subdivides the domain of Abdominal A function through direct combinatorial action, conferring specificity and diversity upon Abdominal A activity...
  42. Ayala F, Campbell C, Selander R. Molecular population genetics of the alcohol dehydrogenase locus in the Hawaiian drosophilid D. mimica. Mol Biol Evol. 1996;13:1363-7 pubmed publisher
    ..The effective population size was estimated to be only slightly smaller than that of continental species and, surprisingly, on the same order of magnitude as the actual size...
  43. Baggio F, Bozzato A, Benna C, Leonardi E, Romoli O, Cognolato M, et al. 2mit, an intronic gene of Drosophila melanogaster timeless2, is involved in behavioral plasticity. PLoS ONE. 2013;8:e76351 pubmed publisher
  44. Schiff N, Feng Y, Quine J, Krasney P, Cavener D. Evolution of the expression of the Gld gene in the reproductive tract of Drosophila. Mol Biol Evol. 1992;9:1029-49 pubmed
    ..GLD expression patterns of these transformants displayed characteristics that are unique to both species, suggesting the presence of both cis- and trans-acting differences between these two species. ..
  45. Tarr o R, Rodr guez Trelles F, Ayala F. Tree rooting with outgroups when they differ in their nucleotide composition from the ingroup: the Drosophila saltans and willistoni groups, a case study. Mol Phylogenet Evol. 2000;16:344-9 pubmed publisher
  46. Noor M, Johnson N, Hey J. Gene flow between Drosophila pseudoobscura and D. persimilis. Evolution. 2000;54:2174-5; discussion 2176-7 pubmed
  47. Torok I, Hartenstein K, Kalmes A, Schmitt R, Strand D, Mechler B. The l(2)gl homologue of Drosophila pseudoobscura suppresses tumorigenicity in transgenic Drosophila melanogaster. Oncogene. 1993;8:1537-49 pubmed
    ..melanogaster and lead to the synthesis of a transgenic protein that has enough specificity conserved for replacing the tumour-suppressor function normally fulfilled by the D. melanogaster l(2)gl protein. ..
  48. Mohammed J, Flynt A, Siepel A, Lai E. The impact of age, biogenesis, and genomic clustering on Drosophila microRNA evolution. RNA. 2013;19:1295-308 pubmed publisher
    ..These studies highlight the previously unappreciated impact of biogenesis strategy and genomic location on the evolutionary dynamics of miRNAs, and affirm that miRNAs do not evolve as a unitary class...
  49. Mar n I, Franke A, Bashaw G, Baker B. The dosage compensation system of Drosophila is co-opted by newly evolved X chromosomes. Nature. 1996;383:160-3 pubmed publisher
    ..In this neo-X chromosome, the pattern of MSL binding correlates with the known pattern of dosage compensation...
  50. Hey J, Nielsen R. Multilocus methods for estimating population sizes, migration rates and divergence time, with applications to the divergence of Drosophila pseudoobscura and D. persimilis. Genetics. 2004;167:747-60 pubmed publisher
    ..Several loci have nonzero estimates of gene flow since the initial separation of the species, with considerable variation in gene flow estimates among loci, in both directions between the species...
  51. Gailey D, Billeter J, Liu J, Bauzon F, Allendorfer J, Goodwin S. Functional conservation of the fruitless male sex-determination gene across 250 Myr of insect evolution. Mol Biol Evol. 2006;23:633-43 pubmed publisher
    ..Given these conserved features within the context of 250 Myr of evolutionary divergence between Drosophila and Anopheles, we hypothesize that fru is the prototypic gene of male sexual behavior among dipteran insects...
  52. Tautz D. Evolution of transcriptional regulation. Curr Opin Genet Dev. 2000;10:575-9 pubmed
    ..Evidence is accumulating for the involvement of regulatory evolution in morphological changes between closely related species, as well as in major changes of body plans...
  53. Bennett S, Noor M. Molecular evolution of a Drosophila homolog of human BRCA2. Genetica. 2009;137:213-9 pubmed publisher
    ..Overall, we have documented patterns and modes of evolution in a new model system of a gene which is important to human health...
  54. Wright V, Vogt K, Smythe E, Zeidler M. Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. Cell Signal. 2011;23:920-7 pubmed publisher
    ..Finally, investigations into the effects of ectopic expression of Upd3 in vivo have confirmed its ability to activate pathway signalling at long-distance...
  55. Friedman T, Burnett J, Lootens S, Steinman R, Wallrath L. The urate oxidase gene of Drosophila pseudoobscura and Drosophila melanogaster: evolutionary changes of sequence and regulation. J Mol Evol. 1992;34:62-77 pubmed
    ..melanogaster UO gene that is capable of conferring a wild-type D. melanogaster pattern of UO regulation on a UO-lacZ fusion gene...
  56. Zhang Z, Kishino H. Genomic background drives the divergence of duplicated amylase genes at synonymous sites in Drosophila. Mol Biol Evol. 2004;21:222-7 pubmed publisher
    ..Both of these hypotheses imply the importance of the genomic background as a driving force of divergence between non-tandemly duplicated genes...
  57. ten Bosch J, Benavides J, Cline T. The TAGteam DNA motif controls the timing of Drosophila pre-blastoderm transcription. Development. 2006;133:1967-77 pubmed publisher
  58. Paris M, Kaplan T, Li X, Villalta J, Lott S, Eisen M. Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression. PLoS Genet. 2013;9:e1003748 pubmed publisher
  59. Brady J, Richmond R. An evolutionary model for the duplication and divergence of esterase genes in Drosophila. J Mol Evol. 1992;34:506-21 pubmed
    ..However, different levels of amino acid substitution between the paralogous genes in D. melanogaster relative to those in D. pseudoobscura suggest that interspecific differences in selection also exist...
  60. Randazzo F, Cribbs D, Kaufman T. Rescue and regulation of proboscipedia: a homeotic gene of the Antennapedia Complex. Development. 1991;113:257-71 pubmed
  61. Machado C, Hey J. The causes of phylogenetic conflict in a classic Drosophila species group. Proc Biol Sci. 2003;270:1193-202 pubmed publisher
  62. J ger H, Herzig B, Herzig A, Sticht H, Lehner C, Heidmann S. Structure predictions and interaction studies indicate homology of separase N-terminal regulatory domains and Drosophila THR. Cell Cycle. 2004;3:182-8 pubmed
    ..The compatibility of these folds with a wide range of primary sequences has likely allowed the rapid divergence of THR/N-terminal separase sequences and securins, which contact this region...
  63. Schully S, Hellberg M. Positive selection on nucleotide substitutions and indels in accessory gland proteins of the Drosophila pseudoobscura subgroup. J Mol Evol. 2006;62:793-802 pubmed publisher
    ..pseudoobscura subgroup were up to several times those in noncoding regions of the Drosophila genome. This suggests that indel substitutions may be under positive selection and may play a key role in the divergence of some Acps...
  64. Chung S, Kim S, Yoon J, Adler P, Yim J. The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing. Genetics. 2007;176:891-903 pubmed publisher
    ..Genetic interaction and gain-of-function studies provide evidence that Tow acts downstream of Fz/Dsh and plays a role in restricting the number of hairs that wing cells form...
  65. Baumann A, Fujiwara Y, Wilson T. Evolutionary divergence of the paralogs Methoprene tolerant (Met) and germ cell expressed (gce) within the genus Drosophila. J Insect Physiol. 2010;56:1445-55 pubmed publisher
    ..Our results suggest that Drosophila Met and gce experienced divergent evolutionary pressures following the duplication of an ancestral gce-like gene found in less derived holometabolous insects...
  66. Price N, Cartwright R, Sabath N, Graur D, Azevedo R. Neutral evolution of robustness in Drosophila microRNA precursors. Mol Biol Evol. 2011;28:2115-23 pubmed publisher
    ..Instead, the high robustness of Drosophila pre-miRNAs appears to be mostly intrinsic and likely a consequence of selection for functional structures...
  67. Johnson D, Henikoff S. A moveable 5' splice site in adenine phosphoribosyltransferase genes of Drosophila species. Mol Cell Biol. 1989;9:2220-3 pubmed
    ..The production of aberrantly spliced transcripts as a normal feature of gene expression supports a general model of eucaryotic gene evolution through alternative splicing and moveable splice junctions. ..
  68. Moser M, Holley W, Chatterjee A, Mian I. The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains. Nucleic Acids Res. 1997;25:5110-8 pubmed
    ..Examination of a multiple sequence alignment and two three-dimensional structures of proofreading domains has allowed definition of the core sequence, structural and functional elements of this exonuclease domain...
  69. Herzig A, Lehner C, Heidmann S. Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function. Genes Dev. 2002;16:2443-54 pubmed
  70. Carvalho A, Clark A. Y chromosome of D. pseudoobscura is not homologous to the ancestral Drosophila Y. Science. 2005;307:108-10 pubmed publisher
    ..pseudoobscura, and none are shared with the D. melanogaster Y. Hence, the Y chromosome in the D. pseudoobscura lineage appears to have arisen de novo and is not homologous to the D. melanogaster Y...
  71. Macdonald S, Long A. Identifying signatures of selection at the enhancer of split neurogenic gene complex in Drosophila. Mol Biol Evol. 2005;22:607-19 pubmed publisher
    ..All sites in regions apparently visible to various selective forces are candidates for future work to determine their phenotypic effects...
  72. Herranz R, Mateos J, Mas J, Garc a Zaragoza E, Cervera M, Marco R. The coevolution of insect muscle TpnT and TpnI gene isoforms. Mol Biol Evol. 2005;22:2231-42 pubmed publisher
    ..Overall, our approach to comparatively analyze supramolecular complexes reveals coevolutionary trends not only in gene families but in isoforms generated by alternative splicing...
  73. Zhang S, Dailey G, Kwan E, Glasheen B, Sroga G, Page McCaw A. An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion. Genes Dev. 2006;20:1899-910 pubmed publisher
    ..This liberated ectodomain promotes the loss of cell adhesion in a cell-nonautonomous manner. We suggest that tracheal cell adhesion is regulated by a novel mechanism utilizing an MMP and a ninjurin family member...
  74. Harada E, Nakagawa J, Asano T, Taoka M, Sorimachi H, Ito Y, et al. Functional evolution of duplicated odorant-binding protein genes, Obp57d and Obp57e, in Drosophila. PLoS ONE. 2012;7:e29710 pubmed publisher
    ..These findings provide a clue to understanding how the repertoire of OBP genes is maintained in a genome under natural selection...
  75. Parker D, Gardiner A, Neville M, Ritchie M, Goodwin S. The evolution of novelty in conserved genes; evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exons. Heredity (Edinb). 2014;112:300-6 pubmed publisher
    ..Alternative splicing may thus provide a route to gene diversification in key regulatory loci. ..
  76. Wong A, Christopher A, Buehner N, Wolfner M. Immortal coils: conserved dimerization motifs of the Drosophila ovulation prohormone ovulin. Insect Biochem Mol Biol. 2010;40:303-10 pubmed publisher
  77. Marfany G, Gonz lez Duarte R. The Adh genomic region of Drosophila ambigua: evolutionary trends in different species. J Mol Evol. 1991;32:454-62 pubmed
    ..According to our data, both mutation/fixation rates and the distribution of mutations vary over time, which makes it difficult to predict the evolutionary dynamics of specific genome regions...
  78. Popadi A, Anderson W. Evidence for gene conversion in the amylase multigene family of Drosophila pseudoobscura. Mol Biol Evol. 1995;12:564-72 pubmed publisher
    ..Thus, the occurrence of gene conversion in the Amy multigene family seems to be a common feature in the Drosophila species studied so far...
  79. Sanicola M, Sekelsky J, Elson S, Gelbart W. Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed. Genetics. 1995;139:745-56 pubmed
    ..We propose that the en-hh-ptc regulatory loop that is responsible for segmental expression of wingless in the embryo is reutilized in imaginal disks to create a stripe of dpp expression along the A/P compartment boundary...
  80. Peixoto A, Campesan S, Costa R, Kyriacou C. Molecular evolution of a repetitive region within the per gene of Drosophila. Mol Biol Evol. 1993;10:127-39 pubmed publisher
    ..Furthermore, analysis of the data suggests that changes in the length of this variable region might be associated with amino acid replacements in the more conserved flanking sequences...
  81. Balakirev E, Ayala F. Is esterase-P encoded by a cryptic pseudogene in Drosophila melanogaster?. Genetics. 1996;144:1511-8 pubmed
    ..We also conjecture that the rarity of detected pseudogenes in Drosophila may be due to the difficulty of discovering them, because most of them are cryptic...
  82. Arkhipova I, Li J, Meselson M. On the mode of gene-dosage compensation in Drosophila. Genetics. 1997;145:729-36 pubmed
  83. Erickson J, Cline T. Key aspects of the primary sex determination mechanism are conserved across the genus Drosophila. Development. 1998;125:3259-68 pubmed
    ..Expression of sisA and Sxl is as tightly coupled in virilis as it is in melanogaster. Taken together, these data indicate that the same primary sex determination mechanism exists throughout the genus Drosophila...
  84. Amador A, Juan E. Nonfixed duplication containing the Adh gene and a truncated form of the Adhr gene in the Drosophila funebris species group: different modes of evolution of Adh relative to Adhr in Drosophila. Mol Biol Evol. 1999;16:1439-56 pubmed publisher
    ..funebris from the virilis-repleta-Hawaiian clade was estimated as 34.3 Myr, and the divergence time of D. funebris and D. immigrans was estimated as 23.5 Myr...
  85. Bloor J, Kiehart D. zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. Dev Biol. 2001;239:215-28 pubmed publisher
    ..We suggest that nonmuscle myosin-II functions at the muscle termini and the Z-line as an actin crosslinker and acts to maintain the structural integrity of the sarcomere...
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    ..These and other conserved SH2 introns suggest that the SH2 domains in PLC-gamma are derived from an ancestral domain that was shuffled not only into PLC-gamma, but also into many other unrelated genes during animal evolution...
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