Drosophila erecta

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Top Publications

  1. Takezaki N, Rzhetsky A, Nei M. Phylogenetic test of the molecular clock and linearized trees. Mol Biol Evol. 1995;12:823-33 pubmed publisher
    ..A linearized tree will then be constructed for a given topology for the remaining sequences under the assumption of rate constancy. We have used these methods to analyze hominoid mitochondrial DNA and drosophilid Adh gene sequences...
  2. Ludwig M, Patel N, Kreitman M. Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change. Development. 1998;125:949-58 pubmed
    ..This view allows for a slow but continual turnover of functionally important changes in the stripe 2 enhancer. ..
  3. Ludwig M, Bergman C, Patel N, Kreitman M. Evidence for stabilizing selection in a eukaryotic enhancer element. Nature. 2000;403:564-7 pubmed
    ..Sequence differences between species have functional consequences, therefore, but they are masked by other co-evolved differences. On the basis of these results, we present a model for the evolution of eukaryotic regulatory sequences. ..
  4. Malik H, Vermaak D, Henikoff S. Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone. Proc Natl Acad Sci U S A. 2002;99:1449-54 pubmed publisher
    ..The recurrent evolution of these motifs in CenH3 suggests a packaging function for the N-terminal tail, which results in a unique chromatin organization at the primary constriction, the cytological marker of centromeres...
  5. Vermaak D, Hayden H, Henikoff S. Centromere targeting element within the histone fold domain of Cid. Mol Cell Biol. 2002;22:7553-61 pubmed
    ..We suggest that the process of deposition of (Cid.H4)2 tetramers allows for discriminating contacts to be made between loop I and DNA, providing the specificity needed for targeting. ..
  6. Andrioli L, Vasisht V, Theodosopoulou E, Oberstein A, Small S. Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms. Development. 2002;129:4931-40 pubmed
    ..These results suggest a common mechanism for preventing anterior activation of three different eve enhancers. ..
  7. Sanchez Gracia A, Aguade M, Rozas J. Patterns of nucleotide polymorphism and divergence in the odorant-binding protein genes OS-E and OS-F: analysis in the melanogaster species subgroup of Drosophila. Genetics. 2003;165:1279-88 pubmed
    ..These results are unlikely under the neutral model and suggest the action of natural selection in the evolution of the two odorant-binding protein genes. ..
  8. Barbash D, Awadalla P, Tarone A. Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus. PLoS Biol. 2004;2:e142 pubmed
    ..Our findings suggest that multiple substitutions driven by natural selection may be a general phenomenon required to generate hybrid incompatibility alleles. ..
  9. Ludwig M, Palsson A, Alekseeva E, Bergman C, Nathan J, Kreitman M. Functional evolution of a cis-regulatory module. PLoS Biol. 2005;3:e93 pubmed
    ..Our findings have implications for understanding enhancer structure-function, mechanisms of speciation and computational identification of regulatory modules. ..

More Information

Publications116 found, 100 shown here

  1. Matsuo T. Rapid evolution of two odorant-binding protein genes, Obp57d and Obp57e, in the Drosophila melanogaster species group. Genetics. 2008;178:1061-72 pubmed publisher
    ..Our analyses demonstrate that these two classes of differences can be distinguished by comparisons of many genomic sequences from closely related species...
  2. Satija R, Pachter L, Hein J. Combining statistical alignment and phylogenetic footprinting to detect regulatory elements. Bioinformatics. 2008;24:1236-42 pubmed publisher
    ..SAPF is freely available to download online at http://www.stats.ox.ac.uk/~satija/SAPF/..
  3. Yassin A, Bastide H, Chung H, Veuille M, David J, Pool J. Ancient balancing selection at tan underlies female colour dimorphism in Drosophila erecta. Nat Commun. 2016;7:10400 pubmed publisher
    ..We investigate a potential case of sexual mimicry in Drosophila erecta, in which females show contrasting resemblance to males...
  4. Mansourian S, Enjin A, Jirle E, Ramesh V, Rehermann G, Becher P, et al. Wild African Drosophila melanogaster Are Seasonal Specialists on Marula Fruit. Curr Biol. 2018;: pubmed publisher
    ..melanogaster are seasonal specialists, in a similar manner to, e.g., Drosophila erecta on screw pine cones [2]...
  5. Andersson S, Lambertsson A. Evolution of the dec-1 eggshell locus in Drosophila. I. Restriction site mapping and limited sequence comparison in the melanogaster species subgroup. J Mol Evol. 1991;33:321-31 pubmed
    ..teissieri and D. yakuba. ..
  6. Shibata H, Yamazaki T. A comparative study of the enzymological features of alpha-amylase in the Drosophila melanogaster species subgroup. Jpn J Genet. 1994;69:251-8 pubmed
    ..We found clear differences in the enzymological features between the species. Thus these differences might reflect an adaptation of the amylase enzyme system to speciation in this species subgroup. ..
  7. Dru P, Bras F, Dez l e S, Gay P, Petitjean A, Pierre Deneubourg A, et al. Unusual variability of the Drosophila melanogaster ref(2)P protein which controls the multiplication of sigma rhabdovirus. Genetics. 1993;133:943-54 pubmed
    ..Nevertheless, nucleotide sequence comparison with the Drosophila erecta ref(2)P gene shows that selective pressures are exerted to maintain the existence of a functional protein...
  8. Liberman L, Stathopoulos A. Design flexibility in cis-regulatory control of gene expression: synthetic and comparative evidence. Dev Biol. 2009;327:578-89 pubmed publisher
    ..We propose a model for neurogenic ectoderm specification in which gene regulation occurs at the intersection of temporal and spatial transcription factor inputs...
  9. Munte A, Aguade M, Segarra C. Changes in the recombinational environment affect divergence in the yellow gene of Drosophila. Mol Biol Evol. 2001;18:1045-56 pubmed
    ..In contrast, the change in the recombinational environment of the y gene has no detectable effect on the rate of amino acid replacement in the Yellow protein. ..
  10. Phinchongsakuldit J, MacArthur S, Brookfield J. Evolution of developmental genes: molecular microevolution of enhancer sequences at the Ubx locus in Drosophila and its impact on developmental phenotypes. Mol Biol Evol. 2004;21:348-63 pubmed publisher
    ..Estimated phylogenetic trees have been constructed for the three enhancer regions investigated. Neither of the two phenotypic traits investigated shows any significant associations with the phylogeny of any of the three enhancers...
  11. Kamimura Y. Significance of constraints on genital coevolution: Why do female Drosophila appear to cooperate with males by accepting harmful matings?. Evolution. 2016;70:1674-83 pubmed publisher
    ..development of such organs, I examined the effects of artificial damage to various genital parts of female Drosophila erecta on reproductive success...
  12. Yurlova A, Makunin I, Kolesnikova T, Posukh O, Belyaeva E, Zhimulev I. Conservation of domain structure in a fast-evolving heterochromatic SUUR protein in drosophilids. Genetics. 2009;183:119-29 pubmed publisher
    ..The C terminus contains interlacing conserved and variable motifs. Our results suggest that SUUR domains evolve with different rates and patterns but maintain their features. ..
  13. Hsu S, Yonekura S, Ting C, Robertson H, Iwai Y, Uemura T, et al. Conserved alternative splicing and expression patterns of arthropod N-cadherin. PLoS Genet. 2009;5:e1000441 pubmed publisher
    ..Ectopic muscle expression of either isoform beyond the time it normally ceases leads to paralysis and lethality. Together, our results offer an example of well-conserved alternative splicing increasing cellular diversity in metazoans...
  14. Tatarenkov A, Zurovcov M, Ayala F. Ddc and amd sequences resolve phylogenetic relationships of Drosophila. Mol Phylogenet Evol. 2001;20:321-5 pubmed publisher
  15. Llopart A, Comeron J. Recurrent events of positive selection in independent Drosophila lineages at the spermatogenesis gene roughex. Genetics. 2008;179:1009-20 pubmed publisher
    ..Most important, we detect the significant and consistent signature of positive selection in several independent Drosophila lineages, which evidences recurrent and concurrent events of adaptive evolution after rux formation...
  16. Coste F, Kemp C, Bobezeau V, Hetru C, Kellenberger C, Imler J, et al. Crystal structure of Diedel, a marker of the immune response of Drosophila melanogaster. PLoS ONE. 2012;7:e33416 pubmed publisher
  17. Matsumoto H, Tsuzuki S, Date Ito A, Ohnishi A, Hayakawa Y. Characteristics common to a cytokine family spanning five orders of insects. Insect Biochem Mol Biol. 2012;42:446-54 pubmed publisher
    ..These data indicate that these small cytokines belonging to one family are present in at least five insect orders. ..
  18. Moriyama E, Hartl D. Codon usage bias and base composition of nuclear genes in Drosophila. Genetics. 1993;134:847-58 pubmed
    ..Our analysis verifies these predictions and also identifies additional selective constraints at the translational level in Drosophila...
  19. Zhan Z, Ding Y, Zhao R, Zhang Y, Yu H, Zhou Q, et al. Rapid functional divergence of a newly evolved polyubiquitin gene in Drosophila and its role in the trade-off between male fecundity and lifespan. Mol Biol Evol. 2012;29:1407-16 pubmed publisher
    ..These results suggest that CG11700 might have experienced neofunctionalization and evolved important functions in the trade-off between male fecundity and lifespan and that CG32744 likely has retained the ancestral function. ..
  20. Kyriacou C. Sex variations. Trends Genet. 1992;8:261-3 pubmed
  21. Meyerowitz E, Martin C. Adjacent chromosomal regions can evolve at very different rates: evolution of the Drosophila 68C glue gene cluster. J Mol Evol. 1984;20:251-64 pubmed
    ..melanogaster glue mRNAs. The highly conserved region is at least 13,000 bp long, and is not known to code for any RNAs. ..
  22. Malaspinas A, Eriksson N, Huggins P. Parametric analysis of alignment and phylogenetic uncertainty. Bull Math Biol. 2011;73:795-810 pubmed publisher
    ..We show that phylogeny estimates can be sensitive to the choice of alignment parameters, and that parametric alignment elucidates the relationship between alignment parameters and reconstructed trees. ..
  23. Sirot L, Findlay G, Sitnik J, Frasheri D, Avila F, Wolfner M. Molecular characterization and evolution of a gene family encoding both female- and male-specific reproductive proteins in Drosophila. Mol Biol Evol. 2014;31:1554-67 pubmed publisher
    ..After duplication and male co-option of one paralog, the evolution of the interacting proteins could have resulted in differential strengths or effects of each paralog. ..
  24. Muhammad Ali A, Burnet B. Ethanol tolerance and variation at the alcohol dehydrogenase (Adh) locus of Drosophila mauritiana. Heredity (Edinb). 1995;74 ( Pt 4):438-44 pubmed
    ..A comparison of larval behaviours shows that D. mauritiana has a lower ethanol tolerance than either of its sibling species D. melanogaster and D. simulans. ..
  25. Da Lage J, Renard E, Chartois F, Lemeunier F, Cariou M. Amyrel, a paralogous gene of the amylase gene family in Drosophila melanogaster and the Sophophora subgenus. Proc Natl Acad Sci U S A. 1998;95:6848-53 pubmed
    ..Amyrel evolves about twice as fast as Amy in the several species studied. We suggest that this gene could result from a duplication of Amy followed by accelerated and selected divergence toward a new adaptation. ..
  26. Schiff N, Feng Y, Quine J, Krasney P, Cavener D. Evolution of the expression of the Gld gene in the reproductive tract of Drosophila. Mol Biol Evol. 1992;9:1029-49 pubmed
    ..GLD expression patterns of these transformants displayed characteristics that are unique to both species, suggesting the presence of both cis- and trans-acting differences between these two species. ..
  27. Bonneton F, Wegnez M. Developmental variability of metallothionein Mtn gene expression in the species of the Drosophila melanogaster subgroup. Dev Genet. 1995;16:253-63 pubmed publisher
    ..The diversity of Mtn patterns in closely related Drosophila species exemplifies the rapid evolution of a gene regulatory system...
  28. Bichon A, Boukhatem N, Gay P, Dru P, Terzian H, Petitjean A, et al. Genetic and molecular features of Su(P), a gene that interacts with ref(2)P in male fertility of Drosophila melanogaster. Mol Genet Genomics. 2001;265:354-61 pubmed
    ..The Su(P) gene was cloned by P element tagging. The P element-tagged alleles identified a Su(P) transcript as a 1.4-kb mRNA produced in the soma of both males and females, which is also abundant in ovaries. ..
  29. Vermaak D, Henikoff S, Malik H. Positive selection drives the evolution of rhino, a member of the heterochromatin protein 1 family in Drosophila. PLoS Genet. 2005;1:96-108 pubmed publisher
  30. Murawska M, Kunert N, van Vugt J, L ngst G, Kremmer E, Logie C, et al. dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription. Mol Cell Biol. 2008;28:2745-57 pubmed publisher
    ..Unlike dMi-2, dCHD3 exists as a monomer. Nevertheless, both proteins colocalize with RNA polymerase II to actively transcribed regions on polytene chromosomes, suggesting that both remodelers participate in the process of transcription...
  31. Parker D, Gardiner A, Neville M, Ritchie M, Goodwin S. The evolution of novelty in conserved genes; evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exons. Heredity (Edinb). 2014;112:300-6 pubmed publisher
    ..Alternative splicing may thus provide a route to gene diversification in key regulatory loci. ..
  32. Wong A, Turchin M, Wolfner M, Aquadro C. Evidence for positive selection on Drosophila melanogaster seminal fluid protease homologs. Mol Biol Evol. 2008;25:497-506 pubmed publisher
    ..The second gene, CG9997, was previously shown to be essential for normal sperm usage, suggesting that sexual selection may underlie its history of adaptation...
  33. Johnson L, Zhao Y, Golden K, Barolo S. Reverse-engineering a transcriptional enhancer: a case study in Drosophila. Tissue Eng Part A. 2008;14:1549-59 pubmed publisher
    ..Implications for developmental genetics, mathematical modeling, and therapeutic applications are discussed. ..
  34. Hare E, Peterson B, Iyer V, Meier R, Eisen M. Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation. PLoS Genet. 2008;4:e1000106 pubmed publisher
    ..Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function...
  35. Lu J, Chen Z. Isolation, characterization and anti-cancer activity of SK84, a novel glycine-rich antimicrobial peptide from Drosophila virilis. Peptides. 2010;31:44-50 pubmed publisher
    ..Our results show that SK84 represents a novel glycine-rich peptide family in Drosophila species with antimicrobial and anti-cancer cell activities. ..
  36. Casso D, Liu S, Biehs B, Kornberg T. Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease. PLoS ONE. 2012;7:e33827 pubmed publisher
    ..This was unexpected given that genetic knockdown phenotypes in other organisms suggested significant roles for Spp-related proteases. ..
  37. Georgel P, Bellard F, Dretzen G, Jagla K, Richards G, Bellard M. GEBF-I in Drosophila species and hybrids: the co-evolution of an enhancer and its cognate factor. Mol Gen Genet. 1992;235:104-12 pubmed
    ..In these hybrid larvae, which carry one D. melanogaster and one D. simulans Sgs-3 gene, the hybrid GEBF-I protein appears equally effective in the induction of both target genes. ..
  38. Okuyama E, Shibata H, Tachida H, Yamazaki T. Molecular evolution of the 5'-flanking regions of the duplicated Amy genes in Drosophila melanogaster species subgroup. Mol Biol Evol. 1996;13:574-83 pubmed
    ..From these observations, we discuss a possibility of positive selection acting on the subregion immediately upstream of the Amy coding region to cause divergence of regulatory elements of the paralogous genes. ..
  39. Lunetti P, Cappello A, Marsano R, Pierri C, Carrisi C, Martello E, et al. Mitochondrial glutamate carriers from Drosophila melanogaster: biochemical, evolutionary and modeling studies. Biochim Biophys Acta. 2013;1827:1245-55 pubmed publisher
  40. Renault A, Axton J. Identification of plu genes and cis-acting elements of PCNA in the Drosophila genus using conservation of gene order. Gene. 2003;307:77-86 pubmed
    ..Of the transcriptional control elements of D. melanogaster PCNA, we found that three motifs 5' to the PCNA transcription unit are conserved in Drosophila species. ..
  41. Ludwig A, Loreto E. Evolutionary pattern of the gtwin retrotransposon in the Drosophila melanogaster subgroup. Genetica. 2007;130:161-8 pubmed publisher
    ..melanogaster. The results suggest that the gtwin element may be an infectious retrovirus able to invade the genome of new species, supporting the gtwin evolutionary picture shown in this work...
  42. Shibata H, Yamazaki T. Molecular evolution of the duplicated Amy locus in the Drosophila melanogaster species subgroup: concerted evolution only in the coding region and an excess of nonsynonymous substitutions in speciation. Genetics. 1995;141:223-36 pubmed
    ..erecta were found to be nonsynonymous. We thus conclude that adaptive protein evolution occurred in the lineage of D. erecta that is a "specialist" species for host plants and probably also occurs in the process of speciation in general...
  43. Inomata N, Tachida H, Yamazaki T. Molecular evolution of the Amy multigenes in the subgenus Sophophora of Drosophila. Mol Biol Evol. 1997;14:942-50 pubmed
    ..The heterogeneity in the relative numbers of synonymous and replacement substitutions among the lineages was found. Possible roles of selection in the sequence evolution of the Amy gene are discussed. ..
  44. Wang S, Magoulas C, Hickey D. Concerted evolution within a trypsin gene cluster in Drosophila. Mol Biol Evol. 1999;16:1117-24 pubmed publisher
    ..of this gene cluster, we isolated and sequenced the homologous 7-kb region from the closely related species Drosophila erecta. A comparison of the DNA sequences between the two species provides strong evidence for the concerted ..
  45. Lachaise D, Harry M, Solignac M, Lemeunier F, B nassi V, Cariou M. Evolutionary novelties in islands: Drosophila santomea, a new melanogaster sister species from São Tomé. Proc Biol Sci. 2000;267:1487-95 pubmed publisher
    ..These were shown to harbour the same Wolbachia endosymbiotic bacteria which could possibly be responsible for mitochondrial DNA hitchhiking across the species barrier...
  46. Kirby D, Muse S, Stephan W. Maintenance of pre-mRNA secondary structure by epistatic selection. Proc Natl Acad Sci U S A. 1995;92:9047-51 pubmed
  47. Stephan W, Kirby D. RNA folding in Drosophila shows a distance effect for compensatory fitness interactions. Genetics. 1993;135:97-103 pubmed
    ..However, the rate of joint fixation drops as distance between sites increases and recombination breaks up favorable combinations. RNA secondary structure was also used to interpret patterns of linkage disequilibrium at Adh...
  48. Davis T, Kurihara J, Yoshino E, Yamamoto D. Genomic organisation of the neural sex determination gene fruitless (fru) in the Hawaiian species Drosophila silvestris and the conservation of the fru BTB protein-protein-binding domain throughout evolution. Hereditas. 2000;132:67-78 pubmed
    ..The genus Zaprionus is placed in the subgenus Drosophila closely related to D. immigrans along with the genera Samoaia and Liodrosophila...
  49. Katoh T, Tamura K, Aotsuka T. Phylogenetic position of the subgenus Lordiphosa of the genus Drosophila (Diptera: Drosophilidae) inferred from alcohol dehydrogenase (Adh) gene sequences. J Mol Evol. 2000;51:122-30 pubmed publisher
  50. Gailey D, Ho S, Ohshima S, Liu J, Eyassu M, Washington M, et al. A phylogeny of the Drosophilidae using the sex-behaviour gene fruitless. Hereditas. 2000;133:81-3 pubmed
  51. Tchoubrieva E, Gibson J. Conserved (CT)n.(GA)n repeats in the non-coding regions at the Gpdh locus are binding sites for the GAGA factor in drosophila melanogaster and its sibling species. Genetica. 2004;121:55-63 pubmed
    ..Using in vitro DNA-footprint analyses we show that the GAGA factor binds to these multiple closely spaced and overlapping conserved (CT)n.(GA)n repeats in D. melanogaster and D. erecta...
  52. Loppin B, Lepetit D, Dorus S, Couble P, Karr T. Origin and neofunctionalization of a Drosophila paternal effect gene essential for zygote viability. Curr Biol. 2005;15:87-93 pubmed publisher
    ..We present a detailed case history of the origin and evolution of a new essential gene and, in so doing, provide the first molecular identification of a Drosophila paternal effect gene, ms(3)K81 (K81)...
  53. Balakirev E, Chechetkin V, Lobzin V, Ayala F. Entropy and GC Content in the beta-esterase gene cluster of the Drosophila melanogaster subgroup. Mol Biol Evol. 2005;22:2063-72 pubmed publisher
    ..The observed differences in entropy and GC content reflect an evolutionary shift associated with the process of pseudogenization and subsequent functional divergence of psiEst-6 and Est-6 after the duplication event...
  54. Zhang Z, Townsend J. Maximum-likelihood model averaging to profile clustering of site types across discrete linear sequences. PLoS Comput Biol. 2009;5:e1000421 pubmed publisher
  55. Miura S, Nozawa M, Nei M. Evolutionary changes of the target sites of two microRNAs encoded in the Hox gene cluster of Drosophila and other insect species. Genome Biol Evol. 2011;3:129-39 pubmed publisher
    ..These results indicate that these regions can be a potential source of generating new target sites, which results in multiple target genes for each miR in animals...
  56. Hickey D, Bally Cuif L, Abukashawa S, Payant V, Benkel B. Concerted evolution of duplicated protein-coding genes in Drosophila. Proc Natl Acad Sci U S A. 1991;88:1611-5 pubmed
    ..This gene conversion process was also seen in the related species Drosophila erecta. Specifically, there is virtual sequence identity between the coding regions of the two genes within each ..
  57. Ross J, Fong P, Cavener D. Correlated evolution of the cis-acting regulatory elements and developmental expression of the Drosophila Gld gene in seven species from the subgroup melanogaster. Dev Genet. 1994;15:38-50 pubmed publisher
    ..Together these data suggest the absence or presence of the TTAGA elements may be responsible for variation in the absence or presence of GLD in the ejaculatory duct among species...
  58. Atrian S, S nchez Pulido L, Gonz lez Duarte R, Valencia A. Shaping of Drosophila alcohol dehydrogenase through evolution: relationship with enzyme functionality. J Mol Evol. 1998;47:211-21 pubmed
    ..Our results define three regions whose shaping has been crucial for ADH differentiation and would be compatible with a contribution of ADH to Drosophila speciation...
  59. Morozov P, Sitnikova T, Churchill G, Ayala F, Rzhetsky A. A new method for characterizing replacement rate variation in molecular sequences. Application of the Fourier and wavelet models to Drosophila and mammalian proteins. Genetics. 2000;154:381-95 pubmed
    ..We illustrate the application of the new method by analyzing human immunoglobulin and Drosophilid alcohol dehydrogenase sequences...
  60. Date Ito A, Kasahara K, Sawai H, Chigusa S. Rapid evolution of the male-specific antibacterial protein andropin gene in Drosophila. J Mol Evol. 2002;54:665-70 pubmed publisher
    ..The series of present results suggests that Andropin was born in the course of constructing the Drosophila Cecropin gene family and then started to evolve rapidly, in contrast to Cecropins...
  61. Gortchakov A, Eggert H, Gan M, Mattow J, Zhimulev I, Saumweber H. Chriz, a chromodomain protein specific for the interbands of Drosophila melanogaster polytene chromosomes. Chromosoma. 2005;114:54-66 pubmed publisher
    ..Reducing Z4 protein does not affect Chriz binding to polytene chromosomes and vice versa. Z4 is still chromosomally bound when Chriz protein is depleted by RNA interference...
  62. Crocker J, Stern D. Functional regulatory evolution outside of the minimal even-skipped stripe 2 enhancer. Development. 2017;144:3095-3101 pubmed publisher
    ..Here, we explore how the Drosophila erecta even-skipped (eve) locus has evolved by testing its activity in the divergent D...
  63. Hedley M, Amrein H, Maniatis T. An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor. Proc Natl Acad Sci U S A. 1995;92:11524-8 pubmed
    ..The first step is transport across the nuclear envelope via the nucleoplasmin-like NLS, while the second step is association with components in the speckled domain via the RS dipeptide sequence...
  64. Soller M, White K. ELAV multimerizes on conserved AU4-6 motifs important for ewg splicing regulation. Mol Cell Biol. 2005;25:7580-91 pubmed publisher
    ..Collectively, our results suggest that ELAV multimerization and binding to multiple AU(4-6) motifs contribute to target RNA recognition and processing in a complex cellular environment...
  65. Drapeau M, Cyran S, Viering M, Geyer P, Long A. A cis-regulatory sequence within the yellow locus of Drosophila melanogaster required for normal male mating success. Genetics. 2006;172:1009-30 pubmed publisher
    ..The MRS contains a regulatory sequence controlling larval pigmentation and a 35-bp sequence that is highly conserved within the genus Drosophila and is predicted to bind known transcription factors...
  66. Bauer DuMont V, Flores H, Wright M, Aquadro C. Recurrent positive selection at bgcn, a key determinant of germ line differentiation, does not appear to be driven by simple coevolution with its partner protein bam. Mol Biol Evol. 2007;24:182-91 pubmed publisher
    ..Differences in the pattern of amino acid fixations between these 2 interacting proteins suggest that the detected positive selection is not due to a simple model of coevolution...
  67. Palmer G, Tran T, Duttlinger A, Nichols R. The drosulfakinin 0 (DSK 0) peptide encoded in the conserved Dsk gene affects adult Drosophila melanogaster crop contractions. J Insect Physiol. 2007;53:1125-33 pubmed publisher
    ..DSK 0, I (DSK I, FDDYGHMRFNH2), and II (DSK II, GGDDQFDDYGHMRFNH2) are encoded in sulfakinin (Dsk). Drosophila erecta, Drosophila sechellia, Drosophila simulans, and Drosophila yakuba shared 62.5-87...
  68. S nchez Gracia A, Rozas J. Divergent evolution and molecular adaptation in the Drosophila odorant-binding protein family: inferences from sequence variation at the OS-E and OS-F genes. BMC Evol Biol. 2008;8:323 pubmed publisher
    ..Thus, the stochastic gene gain/loss process coupled with the impact of natural selection would influence the observed OBP family size...
  69. Shirangi T, Dufour H, Williams T, Carroll S. Rapid evolution of sex pheromone-producing enzyme expression in Drosophila. PLoS Biol. 2009;7:e1000168 pubmed publisher
  70. Patraquim P, Warnefors M, Alonso C. Evolution of Hox post-transcriptional regulation by alternative polyadenylation and microRNA modulation within 12 Drosophila genomes. Mol Biol Evol. 2011;28:2453-60 pubmed publisher
  71. Cariou M, Silvain J, Daubin V, Da Lage J, Lachaise D. Divergence between Drosophila santomea and allopatric or sympatric populations of D. yakuba using paralogous amylase genes and migration scenarios along the Cameroon volcanic line. Mol Ecol. 2001;10:649-60 pubmed
    ..Despite their different modes of evolution and different functions, the Amyrel and Amy genes provide remarkably consistent topologies and hence reflect the same history, that of the species...
  72. Oakeshott J, van Papenrecht E, Claudianos C, Morrish B, Coppin C, Odgers W. An episode of accelerated amino acid change in Drosophila esterase-6 associated with a change in physiological function. Genetica. 2000;110:231-44 pubmed
    ..There are also three changes in glycosylation status. One region predicted to lie on the protein surface which becomes markedly more hydrophilic is proposed to be the ancestral dimerisation site that is lost in the transitional branch...
  73. O Neil M, Belote J. Interspecific comparison of the transformer gene of Drosophila reveals an unusually high degree of evolutionary divergence. Genetics. 1992;131:113-28 pubmed
    ..The tra-homologous genes from two Sophophoran subgenus species, Drosophila simulans and Drosophila erecta, and two Drosophila subgenus species, Drosophila hydei and Drosophila virilis, were cloned, sequenced and ..
  74. Jeffs P, Holmes E, Ashburner M. The molecular evolution of the alcohol dehydrogenase and alcohol dehydrogenase-related genes in the Drosophila melanogaster species subgroup. Mol Biol Evol. 1994;11:287-304 pubmed publisher
    ..melanogaster is the sister species to D. simulans, D. sechellia, and D. mauritiana. The evolutionary relationships of the latter three species remain equivocal...
  75. Parsch J, Stephan W, Tanda S. A highly conserved sequence in the 3'-untranslated region of the drosophila Adh gene plays a functional role in Adh expression. Genetics. 1999;151:667-74 pubmed
    ..The selective difference between these two sequence changes, which have similar effects on ADH activity, may be explained by different metabolic costs associated with the increase in activity...
  76. Rodr guez Trelles F, Tarr o R, Ayala F. Fluctuating mutation bias and the evolution of base composition in Drosophila. J Mol Evol. 2000;50:1-10 pubmed
    ..The shift in mutation bias has affected the extent of the rate variation among sites in Xdh...
  77. Parsch J, Meiklejohn C, Hauschteck Jungen E, Hunziker P, Hartl D. Molecular evolution of the ocnus and janus genes in the Drosophila melanogaster species subgroup. Mol Biol Evol. 2001;18:801-11 pubmed publisher
    ..These results are consistent with previous studies that have detected an increased rate of evolution in genes with reproductive function...
  78. Maheshwari S, Wang J, Barbash D. Recurrent positive selection of the Drosophila hybrid incompatibility gene Hmr. Mol Biol Evol. 2008;25:2421-30 pubmed publisher
    ..Our results suggest that Hmr may be functionally diverged in multiple species...
  79. Satija R, Nov k A, Mikl s I, Lyngs R, Hein J. BigFoot: Bayesian alignment and phylogenetic footprinting with MCMC. BMC Evol Biol. 2009;9:217 pubmed publisher
    ..Our approach is robust to alignment error and uncertainty and can be applied to a variety of biological datasets. The source code and documentation are publicly available for download from http://www.stats.ox.ac.uk/~satija/BigFoot/..
  80. Bertossa R, van de Zande L, Beukeboom L. The Fruitless gene in Nasonia displays complex sex-specific splicing and contains new zinc finger domains. Mol Biol Evol. 2009;26:1557-69 pubmed publisher
    ..Considerable divergences in other parts of the gene are expected to underlie species-specific differences and may help to explain diversity observed in insect sexual behaviors...
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    ..A phylogeny based on the more conserved flanking sequences was produced. The results highlighted some of the problems which are encountered when highly polymorphic genes are used to infer phylogenies of closely related species...
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    ..Future investigations on the adaptation of Drosophila to fermenting resources should consider selective effects of both ethanol and acetic acid...
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    ..Large introns could be a reservoir of genetic diversity, because they have a greater number of mutable sites than short introns. Taken together, gene structure can constrain and/or promote gene evolution...
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    ..Disablement of the ran-like gene in D. yakuba indicates turnover of these duplicates. We discuss the possibility that Dntf-2r and ran-like might be involved in genomic conflicts during spermatogenesis. ..
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    ..Gene products which are predicted to possess long-range elasticity, but do not contain a chitin-binding region, should not be classified as pro-resilin-like proteins until it has been established that they are cuticular proteins...