yellow fever mosquito

Summary

Alias: Aedes aegypti, Stegomyia aegypti

Top Publications

  1. Pullikuth A, Aimanova K, Kang ethe W, Sanders H, Gill S. Molecular characterization of sodium/proton exchanger 3 (NHE3) from the yellow fever vector, Aedes aegypti. J Exp Biol. 2006;209:3529-44 pubmed
    ..Here, we present the identification of sodium/proton exchanger isoform 3 (NHE3) from yellow fever mosquito, Aedes aegypti (AeNHE3)...
  2. Antonova Y, Alvarez K, Kim Y, Kokoza V, Raikhel A. The role of NF-kappaB factor REL2 in the Aedes aegypti immune response. Insect Biochem Mol Biol. 2009;39:303-14 pubmed publisher
    ..Here, we report the generation of two independent transgenic strains of Aedes aegypti overexpressing the NF-?B transcriptional factor REL2, a homologue of Drosophila Relish, which is shown to be ..
  3. Hansen I, Attardo G, Park J, Peng Q, Raikhel A. Target of rapamycin-mediated amino acid signaling in mosquito anautogeny. Proc Natl Acad Sci U S A. 2004;101:10626-31 pubmed
    ..Thus, amino acid-based TOR signaling regulates the activation of egg development after a blood meal, an adaptation to the unique life style of mosquitoes. ..
  4. Stracker T, Thompson S, Grossman G, Riehle M, Brown M. Characterization of the AeaHP gene and its expression in the mosquito Aedes aegypti (Diptera: Culicidae). J Med Entomol. 2002;39:331-42 pubmed
    ..hormone Aea-HP-I, known to inhibit host-seeking behavior, has been characterized for the yellowfever mosquito, Aedes aegypti (L.). The open reading frame reveals a prepropeptide that would be processed into three identical peptides...
  5. Scaraffia P, Isoe J, Murillo A, Wells M. Ammonia metabolism in Aedes aegypti. Insect Biochem Mol Biol. 2005;35:491-503 pubmed publisher
    We investigated the mechanisms by which Aedes aegypti mosquitoes are able to metabolize ammonia...
  6. Chen J, Aimanova K, Pan S, Gill S. Identification and characterization of Aedes aegypti aminopeptidase N as a putative receptor of Bacillus thuringiensis Cry11A toxin. Insect Biochem Mol Biol. 2009;39:688-96 pubmed publisher
    Bacillus thuringiensis subsp. israelensis, which is used worldwide to control Aedes aegypti larvae, produces Cry11Aa and other toxins during sporulation...
  7. Chen L, Zhu J, Sun G, Raikhel A. The early gene Broad is involved in the ecdysteroid hierarchy governing vitellogenesis of the mosquito Aedes aegypti. J Mol Endocrinol. 2004;33:743-61 pubmed
    ..shown that the br gene is involved in the 20E-regulatory hierarchy controlling vitellogenesis in the mosquito, Aedes aegypti. Unlike E74 and E75 early genes, expression of br was activated in previtellogenic females, during a juvenile ..
  8. Pridgeon J, Zhao L, Becnel J, Strickman D, Clark G, Linthicum K. Topically applied AaeIAP1 double-stranded RNA kills female adults of Aedes aegypti. J Med Entomol. 2008;45:414-20 pubmed
    b>Aedes aegypti (L.) (Diptera: Culicidae) is the primary vector of both dengue and yellow fever. Use of insecticides is one of the primary ways to control this medically important insect pest...
  9. Sun G, Zhu J, Li C, Tu Z, Raikhel A. Two isoforms of the early E74 gene, an Ets transcription factor homologue, are implicated in the ecdysteroid hierarchy governing vitellogenesis of the mosquito, Aedes aegypti. Mol Cell Endocrinol. 2002;190:147-57 pubmed
    In the anautogenous mosquito, Aedes aegypti, vitellogenesis is under the strict control of 20-hydroxyecdysone (20E), which is produced via a blood meal-activated hormonal cascade...
  10. Roy S, Raikhel A. Nutritional and hormonal regulation of the TOR effector 4E-binding protein (4E-BP) in the mosquito Aedes aegypti. FASEB J. 2012;26:1334-42 pubmed publisher
    ..Target of rapamycin (TOR) signaling is a key pathway linking blood feeding and egg development in the mosquito Aedes aegypti. We show that the regulation of the TOR effector translational repressor 4E-BP is finely tuned to the ..

Detail Information

Publications138 found, 100 shown here

  1. Pullikuth A, Aimanova K, Kang ethe W, Sanders H, Gill S. Molecular characterization of sodium/proton exchanger 3 (NHE3) from the yellow fever vector, Aedes aegypti. J Exp Biol. 2006;209:3529-44 pubmed
    ..Here, we present the identification of sodium/proton exchanger isoform 3 (NHE3) from yellow fever mosquito, Aedes aegypti (AeNHE3)...
  2. Antonova Y, Alvarez K, Kim Y, Kokoza V, Raikhel A. The role of NF-kappaB factor REL2 in the Aedes aegypti immune response. Insect Biochem Mol Biol. 2009;39:303-14 pubmed publisher
    ..Here, we report the generation of two independent transgenic strains of Aedes aegypti overexpressing the NF-?B transcriptional factor REL2, a homologue of Drosophila Relish, which is shown to be ..
  3. Hansen I, Attardo G, Park J, Peng Q, Raikhel A. Target of rapamycin-mediated amino acid signaling in mosquito anautogeny. Proc Natl Acad Sci U S A. 2004;101:10626-31 pubmed
    ..Thus, amino acid-based TOR signaling regulates the activation of egg development after a blood meal, an adaptation to the unique life style of mosquitoes. ..
  4. Stracker T, Thompson S, Grossman G, Riehle M, Brown M. Characterization of the AeaHP gene and its expression in the mosquito Aedes aegypti (Diptera: Culicidae). J Med Entomol. 2002;39:331-42 pubmed
    ..hormone Aea-HP-I, known to inhibit host-seeking behavior, has been characterized for the yellowfever mosquito, Aedes aegypti (L.). The open reading frame reveals a prepropeptide that would be processed into three identical peptides...
  5. Scaraffia P, Isoe J, Murillo A, Wells M. Ammonia metabolism in Aedes aegypti. Insect Biochem Mol Biol. 2005;35:491-503 pubmed publisher
    We investigated the mechanisms by which Aedes aegypti mosquitoes are able to metabolize ammonia...
  6. Chen J, Aimanova K, Pan S, Gill S. Identification and characterization of Aedes aegypti aminopeptidase N as a putative receptor of Bacillus thuringiensis Cry11A toxin. Insect Biochem Mol Biol. 2009;39:688-96 pubmed publisher
    Bacillus thuringiensis subsp. israelensis, which is used worldwide to control Aedes aegypti larvae, produces Cry11Aa and other toxins during sporulation...
  7. Chen L, Zhu J, Sun G, Raikhel A. The early gene Broad is involved in the ecdysteroid hierarchy governing vitellogenesis of the mosquito Aedes aegypti. J Mol Endocrinol. 2004;33:743-61 pubmed
    ..shown that the br gene is involved in the 20E-regulatory hierarchy controlling vitellogenesis in the mosquito, Aedes aegypti. Unlike E74 and E75 early genes, expression of br was activated in previtellogenic females, during a juvenile ..
  8. Pridgeon J, Zhao L, Becnel J, Strickman D, Clark G, Linthicum K. Topically applied AaeIAP1 double-stranded RNA kills female adults of Aedes aegypti. J Med Entomol. 2008;45:414-20 pubmed
    b>Aedes aegypti (L.) (Diptera: Culicidae) is the primary vector of both dengue and yellow fever. Use of insecticides is one of the primary ways to control this medically important insect pest...
  9. Sun G, Zhu J, Li C, Tu Z, Raikhel A. Two isoforms of the early E74 gene, an Ets transcription factor homologue, are implicated in the ecdysteroid hierarchy governing vitellogenesis of the mosquito, Aedes aegypti. Mol Cell Endocrinol. 2002;190:147-57 pubmed
    In the anautogenous mosquito, Aedes aegypti, vitellogenesis is under the strict control of 20-hydroxyecdysone (20E), which is produced via a blood meal-activated hormonal cascade...
  10. Roy S, Raikhel A. Nutritional and hormonal regulation of the TOR effector 4E-binding protein (4E-BP) in the mosquito Aedes aegypti. FASEB J. 2012;26:1334-42 pubmed publisher
    ..Target of rapamycin (TOR) signaling is a key pathway linking blood feeding and egg development in the mosquito Aedes aegypti. We show that the regulation of the TOR effector translational repressor 4E-BP is finely tuned to the ..
  11. Du Y, Nomura Y, Satar G, Hu Z, Nauen R, He S, et al. Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel. Proc Natl Acad Sci U S A. 2013;110:11785-90 pubmed publisher
    ..Here, we report the successful expression of a sodium channel, AaNav1-1, from Aedes aegypti in Xenopus oocytes, and the functional examination of nine sodium channel mutations that are associated with ..
  12. Calvo E, Walter M, Adelman Z, Jimenez A, Onal S, Marinotti O, et al. Nanos (nos) genes of the vector mosquitoes, Anopheles gambiae, Anopheles stephensi and Aedes aegypti. Insect Biochem Mol Biol. 2005;35:789-98 pubmed
    ..stephensi (Anst nos) and Aedes aegypti (Aeae nos) accumulate in developing oocytes in adult females and localize to the posterior pole in early ..
  13. Garczynski S, Crim J, Brown M. Characterization and expression of the short neuropeptide F receptor in the African malaria mosquito, Anopheles gambiae. Peptides. 2007;28:109-18 pubmed
    ..Membranes from female heads and thoraces exhibited prototypical high affinity binding for radiolabeled sNPF, indicating sNPFR is a bona fide endogenous receptor. ..
  14. Kwon H, Pietrantonio P. Calcitonin receptor 1 (AedaeGPCRCAL1) hindgut expression and direct role in myotropic action in females of the mosquito Aedes aegypti (L.). Insect Biochem Mol Biol. 2013;43:588-93 pubmed publisher
    In anautogenous mosquitoes such as Aedes aegypti females the calcitonin-like diuretic hormone 31 (DH??) stimulates natriuretic fluid excretion from the Malpighian tubules (MTs) after a blood meal...
  15. Wang S, Li C, Sun G, Zhu J, Raikhel A. Differential expression and regulation by 20-hydroxyecdysone of mosquito ecdysteroid receptor isoforms A and B. Mol Cell Endocrinol. 2002;196:29-42 pubmed
    ..These results indicate the mosquito EcR isoforms play distinct physiological functions during vitellogenesis in the mosquito fat body. ..
  16. Kasai S, Komagata O, Itokawa K, Shono T, Ng L, Kobayashi M, et al. Mechanisms of pyrethroid resistance in the dengue mosquito vector, Aedes aegypti: target site insensitivity, penetration, and metabolism. PLoS Negl Trop Dis. 2014;8:e2948 pubmed publisher
    b>Aedes aegypti is the major vector of yellow and dengue fevers. After 10 generations of adult selection, an A...
  17. Gray C, Coates C. Cloning and characterization of cDNAs encoding putative CTCFs in the mosquitoes, Aedes aegypti and Anopheles gambiae. BMC Mol Biol. 2005;6:16 pubmed publisher
    ..We have identified and characterized putative CTCF homologs in the medically-important mosquitoes, Aedes aegypti and Anopheles gambiae...
  18. Choi M, Estep A, Sanscrainte N, Becnel J, Vander Meer R. Identification and expression of PBAN/diapause hormone and GPCRs from Aedes aegypti. Mol Cell Endocrinol. 2013;375:113-20 pubmed publisher
    ..this study we identified and characterized PBAN/pyrokinin peptides and corresponding GPCRs from the mosquito, Aedes aegypti. Ae...
  19. Shao L, Devenport M, Fujioka H, Ghosh A, Jacobs Lorena M. Identification and characterization of a novel peritrophic matrix protein, Ae-Aper50, and the microvillar membrane protein, AEG12, from the mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2005;35:947-59 pubmed publisher
    Immuno-screening of an adult Aedes aegypti midgut cDNA expression library with anti-peritrophic matrix antibodies identified cDNAs encoding a novel peritrophic matrix protein, termed Ae...
  20. Zhu J, Chen L, Sun G, Raikhel A. The competence factor beta Ftz-F1 potentiates ecdysone receptor activity via recruiting a p160/SRC coactivator. Mol Cell Biol. 2006;26:9402-12 pubmed
    ..Thus, our results reveal the molecular basis of competence for the stage-specific 20E response...
  21. Isoe J, Zamora J, Miesfeld R. Molecular analysis of the Aedes aegypti carboxypeptidase gene family. Insect Biochem Mol Biol. 2009;39:68-73 pubmed publisher
    ..in the mosquito midgut, we undertook a comprehensive molecular study of digestive carboxypeptidases in Aedes aegypti. Through a combination of cDNA cloning using degenerate PCR primers, and database mining of the recently ..
  22. Pietrantonio P, Jagge C, McDowell C. Cloning and expression analysis of a 5HT7-like serotonin receptor cDNA from mosquito Aedes aegypti female excretory and respiratory systems. Insect Mol Biol. 2001;10:357-69 pubmed
    In the mosquito Aedes aegypti, 5-HT changes the endogenous rhythm of contractions in the female hindgut and increases fluid secretion in the larval Malpighian tubule. The role of 5-HT as a diuretic hormone in adults has been questioned...
  23. Johnson J, Li J, Christensen B. Cloning and characterization of a dopachrome conversion enzyme from the yellow fever mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2001;31:1125-35 pubmed
    ..study we describe the purification and molecular cloning of a dopachrome conversion enzyme (DCE) from the yellow fever mosquito, Aedes aegypti...
  24. Fang J, Han Q, Li J. Isolation, characterization, and functional expression of kynurenine aminotransferase cDNA from the yellow fever mosquito, Aedes aegypti(1). Insect Biochem Mol Biol. 2002;32:943-50 pubmed
    This study describes the molecular and biochemical characterization of kynurenine aminotransferase (KAT) from Aedes aegypti mosquitoes. Through screening an A...
  25. Shin S, Kokoza V, Bian G, Cheon H, Kim Y, Raikhel A. REL1, a homologue of Drosophila dorsal, regulates toll antifungal immune pathway in the female mosquito Aedes aegypti. J Biol Chem. 2005;280:16499-507 pubmed
    ..characterized the gene homologous to Drosophila Dl and to Anopheles gambiae REL1 (Gambif1) from the yellow fever mosquito Aedes aegypti, named AaREL1. AaREL1 alternative transcripts encode two isoforms, AaREL1-A and AaREL1-B...
  26. Ursic Bedoya R, Mitzey A, Obraztsova M, Lowenberger C. Molecular cloning and transcriptional activation of lysozyme-encoding cDNAs in the mosquito Aedes aegypti. Insect Mol Biol. 2005;14:89-94 pubmed publisher
    ..We identified two lysozyme-encoding cDNAs from Aedes aegypti. Both deduced protein sequences are basic in nature, contain 148 amino acids including eight highly conserved ..
  27. Clemons A, Haugen M, Le C, Mori A, Tomchaney M, Severson D, et al. siRNA-mediated gene targeting in Aedes aegypti embryos reveals that frazzled regulates vector mosquito CNS development. PLoS ONE. 2011;6:e16730 pubmed publisher
    ..expression is detected in neurons just prior to and during axonogenesis in the embryonic ventral nerve cord of Aedes aegypti (dengue vector) and Anopheles gambiae (malaria vector)...
  28. Brengues C, Hawkes N, Chandre F, McCarroll L, Duchon S, Guillet P, et al. Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the voltage-gated sodium channel gene. Med Vet Entomol. 2003;17:87-94 pubmed
    Samples of the dengue vector mosquito Aedes aegypti (L.) (Diptera: Culicidae) were collected from 13 localities between 1995 and 1998...
  29. Patrick M, Aimanova K, Sanders H, Gill S. P-type Na+/K+-ATPase and V-type H+-ATPase expression patterns in the osmoregulatory organs of larval and adult mosquito Aedes aegypti. J Exp Biol. 2006;209:4638-51 pubmed
    ..patterns of P-type Na(+)/K(+)-ATPase and V-type H(+)-ATPase in the larval and adult forms of the mosquito Aedes aegypti and provides insight into their relative importance in ion transport function of key osmoregulatory organs...
  30. Nene V, Wortman J, Lawson D, Haas B, Kodira C, Tu Z, et al. Genome sequence of Aedes aegypti, a major arbovirus vector. Science. 2007;316:1718-23 pubmed
    We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles ..
  31. Piermarini P, Rouhier M, Schepel M, Kosse C, Beyenbach K. Cloning and functional characterization of inward-rectifying potassium (Kir) channels from Malpighian tubules of the mosquito Aedes aegypti. Insect Biochem Mol Biol. 2013;43:75-90 pubmed publisher
    ..to 1) clone the cDNAs of Kir channel subunits expressed in the renal (Malpighian) tubules of the mosquito Aedes aegypti, and 2) characterize the electrophysiological properties of the cloned Kir subunits when expressed ..
  32. Kalhok S, Tabak L, Prosser D, Brook W, Downe A, White B. Isolation, sequencing and characterization of two cDNA clones coding for trypsin-like enzymes from the midgut of Aedes aegypti. Insect Mol Biol. 1993;2:71-9 pubmed
    ..genes by the blood meal, we constructed a cDNA library from mRNA isolated from midguts of blood-fed female Aedes aegypti. The library was screened with a Drosophila melanogaster trypsin-like gene; twelve cDNAs were isolated and ..
  33. Morlais I, Severson D. Identification of a polymorphic mucin-like gene expressed in the midgut of the mosquito, Aedes aegypti, using an integrated bulked segregant and differential display analysis. Genetics. 2001;158:1125-36 pubmed
    ..expressed genes within genome regions containing QTL determining susceptibility of the mosquito, Aedes aegypti, to the malarial parasite, Plasmodium gallinaceum, was investigated using an integrated, targeted approach ..
  34. Campbell C, Keene K, Brackney D, Olson K, Blair C, Wilusz J, et al. Aedes aegypti uses RNA interference in defense against Sindbis virus infection. BMC Microbiol. 2008;8:47 pubmed publisher
    RNA interference (RNAi) is an important anti-viral defense mechanism. The Aedes aegypti genome encodes RNAi component orthologs, however, most populations of this mosquito are readily infected by, and subsequently transmit flaviviruses ..
  35. Chang C, Shen W, Wang T, Lin Y, Hsu E, Dai S. A novel amino acid substitution in a voltage-gated sodium channel is associated with knockdown resistance to permethrin in Aedes aegypti. Insect Biochem Mol Biol. 2009;39:272-8 pubmed publisher
    ..and analyzed from a Per-R strain with 190-fold resistance to permethrin and two susceptible strains of Aedes aegypti. The longest transcript, a 6441bp open reading frame, encodes 2147 amino acid residues with an estimated ..
  36. Cruz J, Sieglaff D, Arensburger P, Atkinson P, Raikhel A. Nuclear receptors in the mosquito Aedes aegypti: annotation, hormonal regulation and expression profiling. FEBS J. 2009;276:1233-54 pubmed publisher
    ..Previous studies have shown that in the yellow fever mosquito Aedes aegypti, nuclear receptors (NRs) play a key role in the endocrine regulation of reproduction...
  37. Meyer J, Ejendal K, Avramova L, Garland Kuntz E, Giraldo Calder n G, Brust T, et al. A "genome-to-lead" approach for insecticide discovery: pharmacological characterization and screening of Aedes aegypti D(1)-like dopamine receptors. PLoS Negl Trop Dis. 2012;6:e1478 pubmed publisher
    ..studies was used to functionally characterize two dopamine receptors (AaDOP1 and AaDOP2) from the yellow fever mosquito, Aedes aegypti...
  38. Mori A, Lobo N, Debruyn B, Severson D. Molecular cloning and characterization of the complete acetylcholinesterase gene (Ace1) from the mosquito Aedes aegypti with implications for comparative genome analysis. Insect Biochem Mol Biol. 2007;37:667-74 pubmed publisher
    ..of the full-length cDNA and characterization of the complete genomic DNA sequence for the Ace1 gene in the yellow fever mosquito, Aedes aegypti. The Ace1 homolog in other mosquito species has been associated with insecticide resistance...
  39. Corena M, Seron T, Lehman H, Ochrietor J, Kohn A, Tu C, et al. Carbonic anhydrase in the midgut of larval Aedes aegypti: cloning, localization and inhibition. J Exp Biol. 2002;205:591-602 pubmed
    ..this enzyme in the alkalization mechanism, to establish its presence and localization in the midgut of larval Aedes aegypti and to clone and characterize its cDNA...
  40. Severson D, Meece J, Lovin D, Saha G, Morlais I. Linkage map organization of expressed sequence tags and sequence tagged sites in the mosquito, Aedes aegypti. Insect Mol Biol. 2002;11:371-8 pubmed
    A composite genetic linkage map for the yellow fever mosquito Aedes aegypti was constructed based on restriction fragment length polymorphism (RFLP), single nucleotide polymorphism (SNP) and single strand conformation polymorphism (SSCP) ..
  41. Umesh A, Cohen B, Ross L, Gill S. Functional characterization of a glutamate/aspartate transporter from the mosquito Aedes aegypti. J Exp Biol. 2003;206:2241-55 pubmed
    ..we report a study conducted on a cloned mosquito EAAT homologue isolated from the vector of the dengue virus, Aedes aegypti. The deduced amino acid sequence of the protein, AeaEAAT, exhibits 40-50% identity with mammalian EAATs, and ..
  42. Sieglaff D, Duncan K, Brown M. Expression of genes encoding proteins involved in ecdysteroidogenesis in the female mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2005;35:471-90 pubmed publisher
    A blood meal induces the ovaries of female Aedes aegypti mosquitoes to produce ecdysteroid hormones that regulate many processes required for egg maturation...
  43. Kato N, Mueller C, Fuchs J, Wessely V, Lan Q, Christensen B. Regulatory mechanisms of chitin biosynthesis and roles of chitin in peritrophic matrix formation in the midgut of adult Aedes aegypti. Insect Biochem Mol Biol. 2006;36:1-9 pubmed publisher
    ..chitin synthase (AeCs), the first and last enzymes of the biosynthetic pathway, respectively, in the midgut of Aedes aegypti. In this study, we demonstrated that formation of the peritrophic matrix is disrupted when the transcript ..
  44. Scaraffia P, Zhang Q, Wysocki V, Isoe J, Wells M. Analysis of whole body ammonia metabolism in Aedes aegypti using [15N]-labeled compounds and mass spectrometry. Insect Biochem Mol Biol. 2006;36:614-22 pubmed publisher
    ..kinetics of incorporation of 15N into glutamine (Gln), glutamic acid (Glu), alanine (Ala) and proline (Pro) in Aedes aegypti females...
  45. Gentile C, Meireles Filho A, Britto C, Lima J, Valle D, Peixoto A. Cloning and daily expression of the timeless gene in Aedes aegypti (Diptera:Culicidae). Insect Biochem Mol Biol. 2006;36:878-84 pubmed publisher
    ..In this paper, we report the cloning and expression analysis of the clock gene timeless in the mosquito Aedes aegypti, vector of Dengue and Yellow Fever viruses...
  46. Zhao L, Pridgeon J, Becnel J, Clark G, Linthicum K. Identification of genes differentially expressed during heat shock treatment in Aedes aegypti. J Med Entomol. 2009;46:490-5 pubmed
    ..subtractive hybridization (SSH) was used to identify target transcripts to heat shock treatment in female Aedes aegypti. Subtraction was performed in both directions enriching for cDNAs differentially expressed between a non-heat ..
  47. Piermarini P, Grogan L, Lau K, Wang L, Beyenbach K. A SLC4-like anion exchanger from renal tubules of the mosquito (Aedes aegypti): evidence for a novel role of stellate cells in diuretic fluid secretion. Am J Physiol Regul Integr Comp Physiol. 2010;298:R642-60 pubmed publisher
    Transepithelial fluid secretion across the renal (Malpighian) tubule epithelium of the mosquito (Aedes aegypti) is energized by the vacuolar-type (V-type) H(+)-ATPase and not the Na(+)-K(+)-ATPase...
  48. Salvemini M, Mauro U, Lombardo F, Milano A, Zazzaro V, Arc B, et al. Genomic organization and splicing evolution of the doublesex gene, a Drosophila regulator of sexual differentiation, in the dengue and yellow fever mosquito Aedes aegypti. BMC Evol Biol. 2011;11:41 pubmed publisher
    ..work, we report on the molecular characterization of the dsx homologue in the dengue and yellow fever vector Aedes aegypti (Aeadsx)...
  49. Mysore K, Flannery E, Tomchaney M, Severson D, Duman Scheel M. Disruption of Aedes aegypti olfactory system development through chitosan/siRNA nanoparticle targeting of semaphorin-1a. PLoS Negl Trop Dis. 2013;7:e2215 pubmed publisher
    ..semaphorin-1a (sema1a) during olfactory system development in the dengue and yellow fever vector mosquito Aedes aegypti. Immunohistochemical analyses and anterograde tracing of antennal sensory neurons, which were used to track ..
  50. Grossman G, James A. The salivary glands of the vector mosquito, Aedes aegypti, express a novel member of the amylase gene family. Insect Mol Biol. 1993;1:223-32 pubmed
    ..been characterized from a library made from adult female salivary gland RNA isolated from the vector mosquito, Aedes aegypti. The corresponding gene, designated Amylase I (Amy I), is expressed specifically in the proximal-lateral lobes ..
  51. Stark K, James A. Isolation and characterization of the gene encoding a novel factor Xa-directed anticoagulant from the yellow fever mosquito, Aedes aegypti. J Biol Chem. 1998;273:20802-9 pubmed
    ..designated Anticoagulant-factor Xa (AFXa), that encodes the factor Xa (FXa)-directed anticoagulant of the yellow fever mosquito, Aedes aegypti...
  52. Gordadze A, Korochkina S, Zakharkin S, Norton A, Benes H. Molecular cloning and expression of two hexamerin cDNAs from the mosquito, Aedes aegypti. Insect Mol Biol. 1999;8:55-66 pubmed
    Fourth-instar larvae of Aedes aegypti synthesize two types of hexamerins, Hexamerin-1 (AaHex-1) and Hexamerin-2 (AaHex-2), whose subunits are distinguished by different methionine and aromatic amino acid contents...
  53. Kato N, Dasgupta R, Smartt C, Christensen B. Glucosamine:fructose-6-phosphate aminotransferase: gene characterization, chitin biosynthesis and peritrophic matrix formation in Aedes aegypti. Insect Mol Biol. 2002;11:207-16 pubmed
    ..We cloned and sequenced the GFAT gene (AeGfat-1) and its 5' regulatory region from Aedes aegypti. There is no intron in AeGfat-1 and there are two potential transcription start sites. AeGfat-1 cDNA is 3...
  54. Krebs K, Brzoza K, Lan Q. Use of subtracted libraries and macroarray to isolate developmentally specific genes from the mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2002;32:1757-67 pubmed
    ..cDNA libraries were screened with cDNA macroarrays to isolate larval and pupal stage-specific genes from Aedes aegypti. Of 103 partial cDNAs sequenced from the 4th instar subtracted cDNA library, 62 have counterpart genes in ..
  55. Vicogne J, Pin J, Lardans V, Capron M, Noël C, Dissous C. An unusual receptor tyrosine kinase of Schistosoma mansoni contains a Venus Flytrap module. Mol Biochem Parasitol. 2003;126:51-62 pubmed
    ..The preferential localization of SmRTK-1 in sporocyst germinal cells and ovocytes could be in favor of its function in schistosome growth and differentiation...
  56. Morlais I, Mori A, Schneider J, Severson D. A targeted approach to the identification of candidate genes determining susceptibility to Plasmodium gallinaceum in Aedes aegypti. Mol Genet Genomics. 2003;269:753-64 pubmed
    ..gallinaceum in the mosquito Aedes aegypti. A total of twenty-two genes were identified and characterized, including five genes with no homologues in ..
  57. Riehle M, Brown J. Characterization of phosphatase and tensin homolog expression in the mosquito Aedes aegypti: six splice variants with developmental and tissue specificity. Insect Mol Biol. 2007;16:277-86 pubmed publisher
    Phosphatase and tensin homologue (PTEN), an inhibitor of insulin signalling, was characterized in Aedes aegypti. Surprisingly, six splice variants were identified: three with alternative terminal exons (AaegPTEN2 : 3 : 6) and three ..
  58. Cooper D, Pio F, Thi E, Theilmann D, Lowenberger C. Characterization of Aedes Dredd: a novel initiator caspase from the yellow fever mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2007;37:559-69 pubmed publisher
    ..Here we describe the identification and characterization of Aedes Dredd (AeDredd), a novel caspase in the yellow fever mosquito, Aedes aegypti...
  59. Bian G, Raikhel A, Zhu J. Characterization of a juvenile hormone-regulated chymotrypsin-like serine protease gene in Aedes aegypti mosquito. Insect Biochem Mol Biol. 2008;38:190-200 pubmed publisher
    ..Here we report identification of a serine-type protease, JHA15, in the yellow fever mosquito Aedes aegypti...
  60. Jagge C, Pietrantonio P. Diuretic hormone 44 receptor in Malpighian tubules of the mosquito Aedes aegypti: evidence for transcriptional regulation paralleling urination. Insect Mol Biol. 2008;17:413-26 pubmed publisher
    In the mosquito Aedes aegypti (L.), the molecular endocrine mechanisms underlying rapid water elimination upon eclosion and blood feeding are not fully understood...
  61. Kaufmann C, Merzendorfer H, G de G. The adipokinetic hormone system in Culicinae (Diptera: Culicidae): molecular identification and characterization of two adipokinetic hormone (AKH) precursors from Aedes aegypti and Culex pipiens and two putative AKH receptor variants from A. aegypti. Insect Biochem Mol Biol. 2009;39:770-81 pubmed publisher
    ..In this study, we identified and analyzed the genes encoding two AKH preprohormones in the Yellow fever mosquito, Aedes aegypti: Aedae-AKH-I encodes the octapeptide pELFTPSWa and Aedae-AKH-II the decapeptide ..
  62. Singarapu K, Radek J, Tonelli M, Markley J, Lan Q. Differences in the structure and dynamics of the apo- and palmitate-ligated forms of Aedes aegypti sterol carrier protein 2 (AeSCP-2). J Biol Chem. 2010;285:17046-53 pubmed publisher
    ..We report here high quality three-dimensional solution structures of SCP-2 from Aedes aegypti determined by NMR spectroscopy in its ligand-free state (AeSCP-2) and in complex with palmitate...
  63. James A, Blackmer K, Racioppi J. A salivary gland-specific, maltase-like gene of the vector mosquito, Aedes aegypti. Gene. 1989;75:73-83 pubmed
    Genomic and cDNA clones of a gene expressed specifically in the salivary glands of adult Aedes aegypti have been isolated and sequenced...
  64. Lin Y, Hamblin M, Edwards M, Barillas Mury C, Kanost M, Knipple D, et al. Structure, expression, and hormonal control of genes from the mosquito, Aedes aegypti, which encode proteins similar to the vitelline membrane proteins of Drosophila melanogaster. Dev Biol. 1993;155:558-68 pubmed publisher
    Genomic and cDNA clones of a gene expressed after a blood meal in the mosquito, Aedes aegypti, were identified as having significant similarity to the vitelline membrane protein genes of Drosophila melanogaster...
  65. Jiang Q, Hall M, Noriega F, Wells M. cDNA cloning and pattern of expression of an adult, female-specific chymotrypsin from Aedes aegypti midgut. Insect Biochem Mol Biol. 1997;27:283-9 pubmed
    A cDNA for a midgut chymotrypsin, induced by a blood meal, has been cloned and sequenced from the mosquito Aedes aegypti. The 938 base sequence codes for a 268 amino acid protein, which contains an 18-residue signal peptide and a seven-..
  66. Veenstra J, Costes L. Isolation and identification of a peptide and its cDNA from the mosquito Aedes aegypti related to Manduca sexta allatotropin. Peptides. 1999;20:1145-51 pubmed
    ..peptide is produced by several neuroendocrince cells in the abdominal ganglia of the mosquito Aedes aegypti. The immunoreactive peptide was isolated and its structure determined to be Ala-Pro-Phe-Arg-Asn-Ser-Glu-Met-..
  67. Pietrantonio P, Jagge C, Keeley L, Ross L. Cloning of an aquaporin-like cDNA and in situ hybridization in adults of the mosquito Aedes aegypti (Diptera: Culicidae). Insect Mol Biol. 2000;9:407-18 pubmed
    A cDNA encoding a putative water channel protein, aquaporin, was cloned from a cDNA library of Aedes aegypti Malpighian tubules. The cDNA encodes a 26...
  68. Cheon H, Seo S, Sun J, Sappington T, Raikhel A. Molecular characterization of the VLDL receptor homolog mediating binding of lipophorin in oocyte of the mosquito Aedes aegypti. Insect Biochem Mol Biol. 2001;31:753-60 pubmed
    Lipophorin (Lp) functions as a yolk protein precursor in the mosquito Aedes aegypti and it is internalized via receptor-mediated endocytosis (Insect Biochem. Mol. Biol., 30 (2000) 1161)...
  69. Shin S, Kokoza V, Ahmed A, Raikhel A. Characterization of three alternatively spliced isoforms of the Rel/NF-kappa B transcription factor Relish from the mosquito Aedes aegypti. Proc Natl Acad Sci U S A. 2002;99:9978-83 pubmed publisher
    ..We cloned and molecularly characterized the gene homologous to Drosophila Relish from the mosquito Aedes aegypti. Unlike Drosophila Relish, Aedes Relish has three alternatively spliced transcripts encoding different ..
  70. Valenzuela J, Pham V, Garfield M, Francischetti I, Ribeiro J. Toward a description of the sialome of the adult female mosquito Aedes aegypti. Insect Biochem Mol Biol. 2002;32:1101-22 pubmed
    To describe the set of mRNA and protein expressed in the salivary glands (sialome) of Aedes aegypti mosquitoes, we randomly sequenced a full-length cDNA library of this insect and performed Edman degradation of PVDF-transferred protein ..
  71. Krebs K, Lan Q. Isolation and expression of a sterol carrier protein-2 gene from the yellow fever mosquito, Aedes aegypti. Insect Mol Biol. 2003;12:51-60 pubmed
    ..6 +/- 0.6 x 10-9 m using radiolabelled cholesterol-binding assay. The results suggest that AeSCP-2 has high affinity to cholesterol and may function as a carrier protein in mosquitoes...
  72. Melo A, R tzler M, Pitts R, Zwiebel L. Identification of a chemosensory receptor from the yellow fever mosquito, Aedes aegypti, that is highly conserved and expressed in olfactory and gustatory organs. Chem Senses. 2004;29:403-10 pubmed publisher
    b>Aedes aegypti is a highly anthropophilic mosquito responsible for the transmission of dengue and yellow fever around the world...
  73. Lumjuan N, McCarroll L, Prapanthadara L, Hemingway J, Ranson H. Elevated activity of an Epsilon class glutathione transferase confers DDT resistance in the dengue vector, Aedes aegypti. Insect Biochem Mol Biol. 2005;35:861-71 pubmed publisher
    ..We have identified eight GST genes in the dengue vector, Aedes aegypti. Four of these belong to the insect specific GST classes Delta and Epsilon and three are from the more ..
  74. Dai L, Adams M. Ecdysis triggering hormone signaling in the yellow fever mosquito Aedes aegypti. Gen Comp Endocrinol. 2009;162:43-51 pubmed publisher
    At the end of each developmental stage, the yellow fever mosquito Aedes aegypti performs the ecdysis behavioral sequence, a precisely timed series of behaviors that culminates in shedding of the old exoskeleton...
  75. Evans A, Aimanova K, Gill S. Characterization of a blood-meal-responsive proton-dependent amino acid transporter in the disease vector, Aedes aegypti. J Exp Biol. 2009;212:3263-71 pubmed publisher
    ..We have identified a proton amino acid transporter (PAT) in Aedes aegypti (AaePAT1, AAEL007191) which facilitates this transport and is expressed in epithelial cell membranes of larval ..
  76. Soares T, Watanabe R, Lemos F, Tanaka A. Molecular characterization of genes encoding trypsin-like enzymes from Aedes aegypti larvae and identification of digestive enzymes. Gene. 2011;489:70-5 pubmed publisher
    Trypsin-like enzymes play an important role in the Aedes aegypti digestive process. The trypsin-like enzymes present in adults were characterized previously, but little is known about trypsins in larvae...
  77. Kwon H, Lu H, Longnecker M, Pietrantonio P. Role in diuresis of a calcitonin receptor (GPRCAL1) expressed in a distal-proximal gradient in renal organs of the mosquito Aedes aegypti (L.). PLoS ONE. 2012;7:e50374 pubmed publisher
    ..Our results with the mosquito AaegGPRCAL1 imply that the regulatory function of calcitonin-like receptors for ion and fluid transport in renal organs arose early in evolution...
  78. Lowenberger C, Smartt C, Bulet P, Ferdig M, Severson D, Hoffmann J, et al. Insect immunity: molecular cloning, expression, and characterization of cDNAs and genomic DNA encoding three isoforms of insect defensin in Aedes aegypti. Insect Mol Biol. 1999;8:107-18 pubmed
    b>Aedes aegypti were immune activated by injection with bacteria, and the expression of insect defensins was measured over time...
  79. Gao Y, Fallon A. Immune activation upregulates lysozyme gene expression in Aedes aegypti mosquito cell culture. Insect Mol Biol. 2000;9:553-8 pubmed
    After stimulation with heat-killed bacteria, cultured cells from the mosquito Aedes aegypti (Aag-2 cells) secreted an induced protein with a mass of approximately 16 kDa that cross-reacted with antibody to chicken egg lysozyme...
  80. Stanek D, Pohl J, Crim J, Brown M. Neuropeptide F and its expression in the yellow fever mosquito, Aedes aegypti. Peptides. 2002;23:1367-78 pubmed
    A neuropeptide F (NPF) was isolated from an extract of adult Aedes aegypti mosquitoes based on its immunoreactivity in a radioimmunoassay for Drosophila NPF...
  81. Ribeiro J, Valenzuela J. The salivary purine nucleosidase of the mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2003;33:13-22 pubmed
    A cDNA clone originating from adult female Aedes aegypti mosquitoes was found with substantial similarity to nucleosidases of the EC 3.2.2.1 enzyme class...
  82. Riehle M, Brown M. Molecular analysis of the serine/threonine kinase Akt and its expression in the mosquito Aedes aegypti. Insect Mol Biol. 2003;12:225-32 pubmed
    ..pathway, the protein kinase Akt, was identified and cloned as a cDNA from ovaries of the mosquito Aedes aegypti. An ortholog gene was found in the Anopheles gambiae genome database, and like other Akts, both mosquito Akts ..
  83. Mu oz D, Jimenez A, Marinotti O, James A. The AeAct-4 gene is expressed in the developing flight muscles of female Aedes aegypti. Insect Mol Biol. 2004;13:563-8 pubmed publisher
    ..to identify such promoters, subtractive cDNA libraries derived from male and female pupal mRNA of the yellow fever mosquito, Aedes aegypti, were constructed and screened...
  84. Riehle M, Fan Y, Cao C, Brown M. Molecular characterization of insulin-like peptides in the yellow fever mosquito, Aedes aegypti: expression, cellular localization, and phylogeny. Peptides. 2006;27:2547-60 pubmed publisher
    ..expression, and tissue localization of eight genes encoding insulin-like peptides (ILPs) in the yellow fever mosquito, Aedes aegypti...
  85. Shin S, Bian G, Raikhel A. A toll receptor and a cytokine, Toll5A and Spz1C, are involved in toll antifungal immune signaling in the mosquito Aedes aegypti. J Biol Chem. 2006;281:39388-95 pubmed publisher
    The fungal-specific immune response in the mosquito Aedes aegypti involves the Toll immune pathway transduced through REL1, a homologue of the NF-kappaB transcription factor Drosophila Dorsal...
  86. Chen Chih Wu R, Shaio M, Cho W. A p38 MAP kinase regulates the expression of the Aedes aegypti defensin gene in mosquito cells. Insect Mol Biol. 2007;16:389-99 pubmed publisher
    An Aedes aegypti p38 (Aap38) mitogen-activated protein kinase was isolated and characterized in this study...
  87. Zhou G, Velasquez L, Geiser D, Mayo J, Winzerling J. Differential regulation of transferrin 1 and 2 in Aedes aegypti. Insect Biochem Mol Biol. 2009;39:234-44 pubmed publisher
    ..Here we characterize the gene and message expression profile of Aedes aegypti transferrin 2 (AaTf2) in response to iron, bacterial challenge and life stage...
  88. Brackney D, Isoe J, W C B, Zamora J, Foy B, Miesfeld R, et al. Expression profiling and comparative analyses of seven midgut serine proteases from the yellow fever mosquito, Aedes aegypti. J Insect Physiol. 2010;56:736-44 pubmed publisher
    b>Aedes aegypti utilizes blood for energy production, egg maturation and replenishment of maternal reserves. The principle midgut enzymes responsible for bloodmeal digestion are endoproteolytic serine-type proteases within the S1...
  89. Likitvivatanavong S, Chen J, Bravo A, Sober n M, Gill S. Cadherin, alkaline phosphatase, and aminopeptidase N as receptors of Cry11Ba toxin from Bacillus thuringiensis subsp. jegathesan in Aedes aegypti. Appl Environ Microbiol. 2011;77:24-31 pubmed publisher
    Cry11Ba is one of the most toxic proteins to mosquito larvae produced by Bacillus thuringiensis. It binds Aedes aegypti brush border membrane vesicles (BBMV) with high affinity, showing an apparent dissociation constant (K(d)) of 8.2 nM...
  90. Marusalin J, Matier B, Rheault M, Donini A. Aquaporin homologs and water transport in the anal papillae of the larval mosquito, Aedes aegypti. J Comp Physiol B. 2012;182:1047-56 pubmed publisher
    The hemolymph osmolarity of the freshwater mosquito larvae (Aedes aegypti) is greater than that of their habitat...
  91. Salvemini M, D Amato R, Petrella V, Aceto S, Nimmo D, Neira M, et al. The orthologue of the fruitfly sex behaviour gene fruitless in the mosquito Aedes aegypti: evolution of genomic organisation and alternative splicing. PLoS ONE. 2013;8:e48554 pubmed publisher
    ..In the mosquito Aedes aegypti sex determination is different from Drosophila...
  92. Zhang G, Hussain M, O Neill S, Asgari S. Wolbachia uses a host microRNA to regulate transcripts of a methyltransferase, contributing to dengue virus inhibition in Aedes aegypti. Proc Natl Acad Sci U S A. 2013;110:10276-81 pubmed publisher
    ..host microRNAs to manipulate host gene expression for its efficient maintenance in the dengue mosquito vector, Aedes aegypti. Cytosine methylation is mediated by a group of proteins called DNA (cytosine-5) methyltransferases, which are ..
  93. Champagne D, Smartt C, Ribeiro J, James A. The salivary gland-specific apyrase of the mosquito Aedes aegypti is a member of the 5'-nucleotidase family. Proc Natl Acad Sci U S A. 1995;92:694-8 pubmed
    ..The yellow-fever mosquito, Aedes aegypti, secretes an apyrase that inhibits ADP-dependent platelet aggregation...
  94. Thompson M, Shotkoski F, ffrench Constant R. Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito Aedes aegypti. Conservation of the gene and resistance associated mutation with Drosophila. FEBS Lett. 1993;325:187-90 pubmed
    ..of the mechanism of cyclodiene insecticide resistance between species we cloned a cDNA from the yellow fever mosquito Aedes aegypti homologous to the resistance gene Rdl in Drosophila. In D...
  95. Scaraffia P, Tan G, Isoe J, Wysocki V, Wells M, Miesfeld R. Discovery of an alternate metabolic pathway for urea synthesis in adult Aedes aegypti mosquitoes. Proc Natl Acad Sci U S A. 2008;105:518-23 pubmed publisher
    We demonstrate the presence of an alternate metabolic pathway for urea synthesis in Aedes aegypti mosquitoes that converts uric acid to urea via an amphibian-like uricolytic pathway...
  96. Brown M, Clark K, Gulia M, Zhao Z, Garczynski S, Crim J, et al. An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti. Proc Natl Acad Sci U S A. 2008;105:5716-21 pubmed publisher
    ..Prior studies with the yellow fever mosquito, Aedes aegypti, indicated blood feeding stimulates egg production by triggering the release of hormones ..
  97. Pri Tal B, Brown J, Riehle M. Identification and characterization of the catalytic subunit of phosphatidylinositol 3-kinase in the yellow fever mosquito Aedes aegypti. Insect Biochem Mol Biol. 2008;38:932-9 pubmed publisher
    We characterized the catalytic subunit of phosphatidylinositol 3-kinase in Aedes aegypti (Aaegp110)...
  98. Cooper D, Chamberlain C, Lowenberger C. Aedes FADD: a novel death domain-containing protein required for antibacterial immunity in the yellow fever mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2009;39:47-54 pubmed publisher
    ..We report here the identification of Aedes FADD (AeFADD), a death domain protein in Aedes aegypti. AeFadd is expressed in all immune-competent tissues and all developmental stages examined...
  99. Rouhier M, Piermarini P. Identification of life-stage and tissue-specific splice variants of an inward rectifying potassium (Kir) channel in the yellow fever mosquito Aedes aegypti. Insect Biochem Mol Biol. 2014;48:91-9 pubmed publisher
    ..The yellow fever mosquito (Aedes aegypti) possesses five different genes encoding Kir channel subunits: Kir1, Kir2A, Kir2B, Kir2B', ..
  100. Hansen I, Attardo G, Roy S, Raikhel A. Target of rapamycin-dependent activation of S6 kinase is a central step in the transduction of nutritional signals during egg development in a mosquito. J Biol Chem. 2005;280:20565-72 pubmed
    ..report the characterization of the TOR kinase and one of its major downstream targets, S6 kinase, of the yellow fever mosquito Aedes aegypti during egg development in adult females...
  101. Stevenson B, Pignatelli P, Nikou D, Paine M. Pinpointing P450s associated with pyrethroid metabolism in the dengue vector, Aedes aegypti: developing new tools to combat insecticide resistance. PLoS Negl Trop Dis. 2012;6:e1595 pubmed publisher
    Pyrethroids are increasingly used to block the transmission of diseases spread by Aedes aegypti such as dengue and yellow fever...