Anopheles gambiae str. PEST


Alias: Anopheles gambiae PEST

Top Publications

  1. Fraiture M, Baxter R, Steinert S, Chelliah Y, Frolet C, Quispe Tintaya W, et al. Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium. Cell Host Microbe. 2009;5:273-84 pubmed publisher
    ..Our results indicate that three major antiparasitic factors in mosquitoes jointly function as a complement-like system in parasite killing, and they reveal a role for LRR proteins as complement control factors. ..
  2. Baxter R, Chang C, Chelliah Y, Blandin S, Levashina E, Deisenhofer J. Structural basis for conserved complement factor-like function in the antimalarial protein TEP1. Proc Natl Acad Sci U S A. 2007;104:11615-20 pubmed
    ..The structure of TEP1r provides a molecular basis for the differences between TEP1 alleles TEP1r and TEP1s, which correlate with resistance of A. gambiae to infection by P. berghei. ..
  3. Meister S, Agianian B, Turlure F, Relógio A, Morlais I, Kafatos F, et al. Anopheles gambiae PGRPLC-mediated defense against bacteria modulates infections with malaria parasites. PLoS Pathog. 2009;5:e1000542 pubmed publisher
    ..A dual role of this isoform is hypothesized: it sequesters monomeric PGN dampening weak signals and locks other PGRPLC isoforms in binary immunostimulatory complexes further enhancing strong signals. ..
  4. Garver L, Bahia A, Das S, Souza Neto J, Shiao J, Dong Y, et al. Anopheles Imd pathway factors and effectors in infection intensity-dependent anti-Plasmodium action. PLoS Pathog. 2012;8:e1002737 pubmed publisher
    ..gambiae as part of an effort to limit the malaria transmission cycle, and they reveal a variety of previously unrecognized nuances in the Imd-directed immune response against P. falciparum. ..
  5. Baxter R, Steinert S, Chelliah Y, Volohonsky G, Levashina E, Deisenhofer J. A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae. Proc Natl Acad Sci U S A. 2010;107:16817-22 pubmed publisher
    ..We propose that a cleaved form of TEP1 may act as a convertase for activation of other TEP1 molecules and that the LRIM1/APL1C heterodimer regulates formation of this TEP1 convertase. ..
  6. Chiu T, Wen Z, Rupasinghe S, Schuler M. Comparative molecular modeling of Anopheles gambiae CYP6Z1, a mosquito P450 capable of metabolizing DDT. Proc Natl Acad Sci U S A. 2008;105:8855-60 pubmed publisher
    ..These data identify CYP6Z1 as one important target for inhibitor design aimed at inactivating insecticide-metabolizing P450s in natural populations of this malarial mosquito. ..
  7. Riehle M, Markianos K, Niare O, Xu J, Li J, Toure A, et al. Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science. 2006;312:577-9 pubmed
  8. Povelones M, Waterhouse R, Kafatos F, Christophides G. Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites. Science. 2009;324:258-61 pubmed publisher
    ..LRIM1 and APL1C are members of a protein family with orthologs in other disease vector mosquitoes and appear to be important effectors in innate mosquito defenses against human pathogens. ..
  9. Michel K, Budd A, Pinto S, Gibson T, Kafatos F. Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei. EMBO Rep. 2005;6:891-7 pubmed
    ..gambiae midguts by the rodent malaria parasite Plasmodium berghei. It did not affect ookinete formation, but markedly reduced oocyst numbers, by 97%, as a result of increased ookinete lysis and melanization. ..

More Information


  1. Gupta L, Molina Cruz A, Kumar S, Rodrigues J, Dixit R, Zamora R, et al. The STAT pathway mediates late-phase immunity against Plasmodium in the mosquito Anopheles gambiae. Cell Host Microbe. 2009;5:498-507 pubmed publisher
    ..Chemical inhibition of mosquito NOS activity after oocyte formation increases oocyte survival. Thus, the AgSTAT-A pathway mediates a late-phase antiplasmodial response that reduces oocyst survival in A. gambiae. ..
  2. Kumar S, Molina Cruz A, Gupta L, Rodrigues J, Barillas Mury C. A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae. Science. 2010;327:1644-8 pubmed publisher
    ..Disruption of this barrier results in strong and effective pathogen-specific immune responses. ..
  3. Alout H, Djogb nou L, Berticat C, Chandre F, Weill M. Comparison of Anopheles gambiae and Culex pipiens acetycholinesterase 1 biochemical properties. Comp Biochem Physiol B Biochem Mol Biol. 2008;150:271-7 pubmed publisher
    ..Consequently, we hypothesize that fitness cost associated with AChE1 insensitivity in C. pipiens mosquitoes should be similar in An. gambiae and thus be used in strategies to control resistant populations where malaria is prevalent...
  4. Riveron J, Yunta C, Ibrahim S, Djouaka R, Irving H, Menze B, et al. A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in a major malaria vector. Genome Biol. 2014;15:R27 pubmed publisher
    ..This first DNA-based metabolic resistance marker in mosquitoes provides an essential tool to track the evolution of resistance and to design suitable resistance management strategies. ..
  5. Zhang X, An C, Sprigg K, Michel K. CLIPB8 is part of the prophenoloxidase activation system in Anopheles gambiae mosquitoes. Insect Biochem Mol Biol. 2016;71:106-15 pubmed publisher
    ..Taken together, this study identifies CLIPB8 as an additional player in proPO activation cascade and highlights the complexity of the proteinase network that regulates melanization in An. gambiae. ..
  6. Li M, Wang J, Zhao Y, Fikrig E. Innexin AGAP001476 is critical for mediating anti-Plasmodium responses in Anopheles mosquitoes. J Biol Chem. 2014;289:24885-97 pubmed publisher
    ..These data demonstrate a critical role for innexin AGAP001476 in mediating innate immune responses against Plasmodium through Toll pathway in mosquitoes. ..
  7. Estévez Lao T, HILLYER J. Involvement of the Anopheles gambiae Nimrod gene family in mosquito immune responses. Insect Biochem Mol Biol. 2014;44:12-22 pubmed publisher
    ..Together, these data show that members of the A. gambiae Nimrod gene family are positive regulators of the mosquito antibacterial response. ..
  8. Wang G, Qiu Y, Lu T, Kwon H, Pitts R, van Loon J, et al. Anopheles gambiae TRPA1 is a heat-activated channel expressed in thermosensitive sensilla of female antennae. Eur J Neurosci. 2009;30:967-74 pubmed publisher
    ..gambiae, providing a basis for targeting mosquito heat responses as a means toward reducing malaria transmission...
  9. Rossi F, Garavaglia S, Giovenzana G, Arc B, Li J, Rizzi M. Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase. Proc Natl Acad Sci U S A. 2006;103:5711-6 pubmed publisher
    ..This study may be useful for the structure-based design of specific enzyme inhibitors of potential interest as antimalarial agents...
  10. Gillardon F. Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro. Neuroscience. 2009;163:533-9 pubmed publisher
    ..These findings suggest that the interaction between LRRK2 and EF1A may reciprocally modulate their physiological function...
  11. Ghosh A, Devenport M, Jethwaney D, Kalume D, Pandey A, Anderson V, et al. Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins. PLoS Pathog. 2009;5:e1000265 pubmed publisher
    ..Together, the results suggest that saglin/TRAP interaction is crucial for salivary gland invasion by Plasmodium sporozoites...
  12. Smith P, Mwangi J, Afrane Y, Yan G, Obbard D, Ranford Cartwright L, et al. Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections. Malar J. 2011;10:156 pubmed publisher
    ..While the data clearly indicate that AgDscam diversity increases with P. falciparum exposure, they do not suggest that AgDscam diversity rises further in response to increased parasite diversity...
  13. Paglino A, Lombardo F, Arc B, Rizzi M, Rossi F. Purification and biochemical characterization of a recombinant Anopheles gambiae tryptophan 2,3-dioxygenase expressed in Escherichia coli. Insect Biochem Mol Biol. 2008;38:871-6 pubmed publisher
    ..Our study could contribute to understanding TDO regulation in vivo and to the identification of inhibitors to be used to alter Tryptophan homeostasis in the malaria vector...
  14. Burmester T, Klawitter S, Hankeln T. Characterization of two globin genes from the malaria mosquito Anopheles gambiae: divergent origin of nematoceran haemoglobins. Insect Mol Biol. 2007;16:133-42 pubmed publisher
    ..0, providing evidence for a recent intron gain event. Both mosquito glob2 genes have lost the B12.2 intron. This pattern must be interpreted in terms of dynamic intron gain and loss events in the globin gene lineage...
  15. Dong Y, Cirimotich C, Pike A, Chandra R, Dimopoulos G. Anopheles NF-?B-regulated splicing factors direct pathogen-specific repertoires of the hypervariable pattern recognition receptor AgDscam. Cell Host Microbe. 2012;12:521-30 pubmed publisher
    ..This mechanism represents an additional level of immune response regulation that may provide a previously unrecognized level of plasticity to the insect immune pathway-regulated antipathogen defenses...
  16. Zhang Q, Hua G, Bayyareddy K, Adang M. Analyses of ?-amylase and ?-glucosidase in the malaria vector mosquito, Anopheles gambiae, as receptors of Cry11Ba toxin of Bacillus thuringiensis subsp. jegathesan. Insect Biochem Mol Biol. 2013;43:907-15 pubmed publisher
    ..6 nM and 21.1 nM respectively. Cry11Ba toxicity against A. gambiae larvae was neutralized by both AgAmy1 and Agm3. The results provide evidence that both AgAmy1 and Agm3 function as receptors of Cry11Ba in A. gambiae...
  17. Kim Y, Spalovsk Valachov I, Cho K, Zitnanova I, Park Y, Adams M, et al. Corazonin receptor signaling in ecdysis initiation. Proc Natl Acad Sci U S A. 2004;101:6704-9 pubmed publisher
    ..These findings support the role of corazonin signaling in initiation of the ecdysis behavioral sequence. We propose a model for peptide-mediated interactions between Inka cells and the CNS underlying this process in insect development...
  18. Talamillo A, Herboso L, Pirone L, P rez C, Gonz lez M, S nchez J, et al. Scavenger receptors mediate the role of SUMO and Ftz-f1 in Drosophila steroidogenesis. PLoS Genet. 2013;9:e1003473 pubmed publisher
  19. Mori A, Lobo N, Debruyn B, Severson D. Molecular cloning and characterization of the complete acetylcholinesterase gene (Ace1) from the mosquito Aedes aegypti with implications for comparative genome analysis. Insect Biochem Mol Biol. 2007;37:667-74 pubmed publisher
    ..The Ace1 locus maps to the p-arm of chromosome 3, which corresponds to the orthologous genome regions in Culex spp. and An. gambiae...
  20. Smith R, Eappen A, Radtke A, Jacobs Lorena M. Regulation of anti-Plasmodium immunity by a LITAF-like transcription factor in the malaria vector Anopheles gambiae. PLoS Pathog. 2012;8:e1002965 pubmed publisher
    ..We conclude that LL3 is a transcription factor capable of modulating SRPN6 expression as part of the mosquito anti-Plasmodium immune response...
  21. Hua G, Zhang Q, Zhang R, Abdullah A, Linser P, Adang M. AgCad2 cadherin in Anopheles gambiae larvae is a putative receptor of Cry11Ba toxin of Bacillus thuringiensis subsp. jegathesan. Insect Biochem Mol Biol. 2013;43:153-61 pubmed publisher
    ..Its binding to Cry11Ba could be completely competed off by AgCad1, but only partially competed by AgALP1. The results are evidence that AgCad2 may function as a receptor for Cry11Ba in A. gambiae larvae...
  22. Horton A, Lee Y, Coulibaly C, Rashbrook V, Cornel A, Lanzaro G, et al. Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection. Malar J. 2010;9:160 pubmed publisher
  23. Tsutsumi S, Kamata N, Vokes T, Maruoka Y, Nakakuki K, Enomoto S, et al. The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). Am J Hum Genet. 2004;74:1255-61 pubmed publisher
    ..Cellular localization to the endoplasmic reticulum suggests a role for GDD1 in the regulation of intracellular calcium homeostasis...
  24. Mitchell S, Stevenson B, M ller P, Wilding C, Egyir Yawson A, Field S, et al. Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana. Proc Natl Acad Sci U S A. 2012;109:6147-52 pubmed publisher
    ..Using in vitro assays we show that recombinant CYP6M2 is also capable of metabolizing the organochlorine insecticide DDT in the presence of solubilizing factor sodium cholate...
  25. Jiang H, Liu S, Zhao P, Pope C. Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiae. Insect Biochem Mol Biol. 2009;39:646-53 pubmed publisher
    ..Furthermore, we found that choline inhibited r-AgAChE1, a phenomenon related to the enzyme activity decrease at high concentrations of acetylcholine...
  26. Liu P, Torrens Spence M, Ding H, Christensen B, Li J. Mechanism of cysteine-dependent inactivation of aspartate/glutamate/cysteine sulfinic acid ?-decarboxylases. Amino Acids. 2013;44:391-404 pubmed publisher
    ..The results of our study should promote research in terms of mechanism by which animals maintain their cysteine homeostasis and possible relationship of cysteine-mediated GDC and CSADC inhibition in neurodegenerative disease development...
  27. Gillardon F. Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?. J Neurochem. 2009;110:1514-22 pubmed publisher
    ..These findings suggest that LRRK2(G2019S)-induced neurodegeneration in Parkinsonian brains may be partly mediated by increased phosphorylation of tubulin-beta and constraining of microtubule dynamics...
  28. Mugumbate G, Jackson G, van der Spoel D, Kövér K, Szilagyi L. Anopheles gambiae, Anoga-HrTH hormone, free and bound structure--a nuclear magnetic resonance experiment. Peptides. 2013;41:94-100 pubmed publisher
    ..Information about the 3D structure and binding mode of Anoga-HrTH to its receptor is vital for the design of suitable mimetics which can act as insecticides. ..
  29. Liu S, Lucas K, Roy S, Ha J, Raikhel A. Mosquito-specific microRNA-1174 targets serine hydroxymethyltransferase to control key functions in the gut. Proc Natl Acad Sci U S A. 2014;111:14460-5 pubmed publisher
    ..The adverse phenotypes caused by miR-1174 silencing were rescued by SHMT RNA interference. Our results suggest that miR-1174 is essential for fine-tuning the SHMT transcript to levels necessary for normal mosquito gut functions. ..
  30. Lombardo F, Ronca R, Rizzo C, Mestres Simòn M, Lanfrancotti A, Currà C, et al. The Anopheles gambiae salivary protein gSG6: an anopheline-specific protein with a blood-feeding role. Insect Biochem Mol Biol. 2009;39:457-66 pubmed publisher
    ..We conclude that gSG6 plays some essential blood feeding role and was recruited in the anopheline subfamily most probably after the separation of the lineage which gave origin to Cellia and Anopheles subgenera. ..
  31. Anto F, Asoala V, Anyorigiya T, Oduro A, Adjuik M, Owusu Agyei S, et al. Insecticide resistance profiles for malaria vectors in the Kassena-Nankana district of Ghana. Malar J. 2009;8:81 pubmed publisher
    ..There is however, the need for continuous monitoring of the pyrethroids as the efficacy is not very high...
  32. Rheault M, Okech B, Keen S, Miller M, Meleshkevitch E, Linser P, et al. Molecular cloning, phylogeny and localization of AgNHA1: the first Na+/H+ antiporter (NHA) from a metazoan, Anopheles gambiae. J Exp Biol. 2007;210:3848-61 pubmed
    ..The tissue localization of AgNHA1 suggests that it plays a key role in maintaining the characteristic longitudinal pH gradient in the lumen of the alimentary canal of An. gambiae larvae. ..
  33. Reimer L, Tripet F, Slotman M, Spielman A, Fondjo E, Lanzaro G. An unusual distribution of the kdr gene among populations of Anopheles gambiae on the island of Bioko, Equatorial Guinea. Insect Mol Biol. 2005;14:683-8 pubmed publisher
    ..The mutation may have recently arisen independently in the M form on Bioko due to recent and intensive pyrethroid application...
  34. Rossi F, Lombardo F, Paglino A, Cassani C, Miglio G, Arcà B, et al. Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase. FEBS J. 2005;272:5653-62 pubmed
    ..This study may be useful for the identification of 3-HK transaminase inhibitors of potential interest as malaria transmission-blocking drugs or effective insecticides. ..
  35. Gailey D, Billeter J, Liu J, Bauzon F, Allendorfer J, Goodwin S. Functional conservation of the fruitless male sex-determination gene across 250 Myr of insect evolution. Mol Biol Evol. 2006;23:633-43 pubmed publisher
    ..Given these conserved features within the context of 250 Myr of evolutionary divergence between Drosophila and Anopheles, we hypothesize that fru is the prototypic gene of male sexual behavior among dipteran insects...
  36. Djogb nou L, Labb P, Chandre F, Pasteur N, Weill M. Ace-1 duplication in Anopheles gambiae: a challenge for malaria control. Malar J. 2009;8:70 pubmed publisher
    ..The spread of this less costly resistance allele could represent a major threat to public health, as it may impede An. gambiae control strategies, and thus increases the risk of malaria outbreaks...
  37. Sodja A, Fujioka H, Lemos F, Donnelly Doman M, Jacobs Lorena M. Induction of actin gene expression in the mosquito midgut by blood ingestion correlates with striking changes of cell shape. J Insect Physiol. 2007;53:833-9 pubmed publisher
    ..These changes correlate with the large increase of epithelial surface area needed to accommodate the blood meal. Actin gene expression, actin synthesis and cell morphology all return to the pre-feeding state by 24 h after blood intake...
  38. Nakabayashi K, Amann D, Ren Y, Saarialho Kere U, Avidan N, Gentles S, et al. Identification of C7orf11 (TTDN1) gene mutations and genetic heterogeneity in nonphotosensitive trichothiodystrophy. Am J Hum Genet. 2005;76:510-6 pubmed publisher
    ..Given the absence of cutaneous photosensitivity in the patients with C7orf11 mutations, together with the protein's nuclear localization, C7orf11 may be involved in transcription but not DNA repair...
  39. Smith K, Vanekeris L, Linser P. Cloning and characterization of AgCA9, a novel alpha-carbonic anhydrase from Anopheles gambiae Giles sensu stricto (Diptera: Culicidae) larvae. J Exp Biol. 2007;210:3919-30 pubmed publisher
    ..gambiae genomes shows a clustering of the novel CA with Homo sapiens CAs but not with other insect CAs. Finally, a universal system for naming newly cloned An. gambiae CAs is suggested...
  40. Opota O, Charles J, Warot S, Pauron D, Darboux I. Identification and characterization of the receptor for the Bacillus sphaericus binary toxin in the malaria vector mosquito, Anopheles gambiae. Comp Biochem Physiol B Biochem Mol Biol. 2008;149:419-27 pubmed publisher
  41. Brooke B. kdr: can a single mutation produce an entire insecticide resistance phenotype?. Trans R Soc Trop Med Hyg. 2008;102:524-5 pubmed publisher
  42. Hua G, Zhang R, Abdullah M, Adang M. Anopheles gambiae cadherin AgCad1 binds the Cry4Ba toxin of Bacillus thuringiensis israelensis and a fragment of AgCad1 synergizes toxicity. Biochemistry. 2008;47:5101-10 pubmed publisher
    ..AgCad1 in the larval brush border is a binding protein for Cry4Ba toxin. On the basis of binding results and CR11-MPED synergism of Cry4Ba toxicity, AgCad1 is probably a Cry4Ba receptor...
  43. M ller P, Warr E, Stevenson B, Pignatelli P, Morgan J, Steven A, et al. Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids. PLoS Genet. 2008;4:e1000286 pubmed publisher
    ..This is the first study to demonstrate the capacity of a P450 identified in wild A. gambiae to metabolise insecticides. The findings add to the understanding of the genetic basis of insecticide resistance in wild mosquito populations...
  44. Dabir K, Diabat A, Namontougou M, Djogbenou L, Kengne P, Simard F, et al. Distribution of insensitive acetylcholinesterase (ace-1R) in Anopheles gambiae s.l. populations from Burkina Faso (West Africa). Trop Med Int Health. 2009;14:396-403 pubmed publisher
    ..These results have special significance as OP and CM insecticides have been proposed as alternatives or additions to pyrethroids which are currently used exclusively in many vector control programmes...
  45. Bertossa R, van de Zande L, Beukeboom L. The Fruitless gene in Nasonia displays complex sex-specific splicing and contains new zinc finger domains. Mol Biol Evol. 2009;26:1557-69 pubmed publisher
    ..Considerable divergences in other parts of the gene are expected to underlie species-specific differences and may help to explain diversity observed in insect sexual behaviors...
  46. Davis C, Crowley L, Barber M. Cytochrome b5 reductase: the roles of the recessive congenital methemoglobinemia mutants P144L, L148P, and R159*. Arch Biochem Biophys. 2004;431:233-44 pubmed publisher
  47. Zhang Q, Hua G, Adang M. Chitosan/DsiRNA nanoparticle targeting identifies AgCad1 cadherin in Anopheles gambiae larvae as an in vivo receptor of Cry11Ba toxin of Bacillus thuringiensis subsp. jegathesan. Insect Biochem Mol Biol. 2015;60:33-8 pubmed publisher
    ..Silencing AgCad expression had no effect on transcript levels of other binding receptors of Cry11Ba. We conclude that AgCad1 and possibly AgCad2 in An. gambiae larvae are functional receptors of Cry11Ba toxin in vivo. ..
  48. Fryxell R, Seifert S, Lee Y, Sacko A, Lanzaro G, Cornel A. The knockdown resistance mutation and knockdown time in Anopheles gambiae collected from Mali evaluated through a bottle bioassay and a novel insecticide-treated net bioassay. J Am Mosq Control Assoc. 2012;28:119-22 pubmed
  49. Williams M, Summers B, Baxter R. Biophysical analysis of anopheles gambiae leucine-rich repeat proteins APL1A1, APL1B [corrected] and APL1C and their interaction with LRIM1. PLoS ONE. 2015;10:e0118911 pubmed publisher
    ..gambiae from a diverse array of pathogens. ..
  50. Diver M, Long S. Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites. J Biol Chem. 2014;289:26007-20 pubmed publisher
    ..The data provide evidence that the active site of ICMT spans both cytosolic and membrane-embedded regions of the protein. ..
  51. Lavazec C, Bonnet S, Thiery I, Boisson B, Bourgouin C. cpbAg1 encodes an active carboxypeptidase B expressed in the midgut of Anopheles gambiae. Insect Mol Biol. 2005;14:163-74 pubmed publisher
    ..Annotation of the An. gambiae genome predicts twenty-three sequences coding for zinc-carboxypeptidases of which only two (cpbAg1 and cpbAg2) are expressed at a significant level in the mosquito midgut...
  52. Du W, Awolola T, Howell P, Koekemoer L, Brooke B, Benedict M, et al. Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis. Insect Mol Biol. 2005;14:179-83 pubmed publisher
    ..An alanine to serine substitution developed independently in a dieldrin resistant strain of An. arabiensis. An allele-specific polymerase chain reaction (PCR) assay was able to differentiate dieldrin resistant and susceptible mosquitoes...
  53. Zhou L, Jiang G, Chan G, Santos C, Severson D, Xiao L. Michelob_x is the missing inhibitor of apoptosis protein antagonist in mosquito genomes. EMBO Rep. 2005;6:769-74 pubmed publisher
    ..Its proapoptotic activity is totally dependent on the IAP-binding motif. Like reaper in Drosophila, mx is transcriptionally induced by ultraviolet irradiation to mediate cell death...
  54. Liu K, Dong Y, Huang Y, Rasgon J, Agre P. Impact of trehalose transporter knockdown on Anopheles gambiae stress adaptation and susceptibility to Plasmodium falciparum infection. Proc Natl Acad Sci U S A. 2013;110:17504-9 pubmed publisher
    ..These data reveal important roles for AgTreT1 in stress adaptation and malaria pathogen development in a major vector mosquito. Thus, AgTreT1 may be a potential target for malaria vector control...
  55. Volz J, Osta M, Kafatos F, M ller H. The roles of two clip domain serine proteases in innate immune responses of the malaria vector Anopheles gambiae. J Biol Chem. 2005;280:40161-8 pubmed publisher
    ..Our findings strongly suggest that clip domain serine proteases serve multiple functions and play distinctive roles in several immune pathways of A. gambiae...
  56. Hu Y, Wang Y, Deng J, Jiang H. The structure of a prophenoloxidase (PPO) from Anopheles gambiae provides new insights into the mechanism of PPO activation. BMC Biol. 2016;14:2 pubmed publisher
    ..This study provides new insights into the mechanisms of PPO activation and enzymatic catalysis of PO. ..
  57. Le B, Nguyen J, Logarajah S, Wang B, MARCUS J, Williams H, et al. Characterization of Anopheles gambiae transglutaminase 3 (AgTG3) and its native substrate Plugin. J Biol Chem. 2013;288:4844-53 pubmed publisher
    ..These results support the development of AgTG3 inhibitors as specific and effective chemosterilants for A. gambiae...
  58. Dottorini T, Persampieri T, Palladino P, Spaccapelo R, Crisanti A. Silencing of the Hsf gene, the transcriptional regulator of A. gambiae male accessory glands, inhibits the formation of the mating plug in mated females and disrupts their monogamous behaviour. Pathog Glob Health. 2012;106:405-12 pubmed publisher
    ..Our findings provide evidence showing that Acp genes regulated by the transcription factor HSF play a key role in the function of the male accessory glands...
  59. Shi L, Li B, Paskewitz S. Cloning and characterization of a putative inhibitor of melanization from Anopheles gambiae. Insect Mol Biol. 2006;15:313-20 pubmed
    ..Gene knockdown did not result in faster or more extensive bead melanization but did result in more extensive melanization of wound sites following a thoracic bead injection. ..
  60. Dong Y, Taylor H, Dimopoulos G. AgDscam, a hypervariable immunoglobulin domain-containing receptor of the Anopheles gambiae innate immune system. PLoS Biol. 2006;4:e229 pubmed publisher
    ..AgDscam is mediating phagocytosis of bacteria with which it can associate and defend against in a splice form-specific manner. AgDscam is a hypervariable PRR of the A. gambiae innate immune system...
  61. Meleshkevitch E, Assis Nascimento P, Popova L, Miller M, Kohn A, Phung E, et al. Molecular characterization of the first aromatic nutrient transporter from the sodium neurotransmitter symporter family. J Exp Biol. 2006;209:3183-98 pubmed publisher
  62. DeJong R, Miller L, Molina Cruz A, Gupta L, Kumar S, Barillas Mury C. Reactive oxygen species detoxification by catalase is a major determinant of fecundity in the mosquito Anopheles gambiae. Proc Natl Acad Sci U S A. 2007;104:2121-6 pubmed publisher
  63. Hoffman S, Aravind L, Velmurugan S. Female Anopheles gambiae antennae: increased transcript accumulation of the mosquito-specific odorant-binding-protein OBP2. Parasit Vectors. 2012;5:27 pubmed publisher
    ..This finding may be a step toward providing a foundation for understanding mosquito olfactory requirements and developing control strategies based on reducing mosquito feeding and breeding success...
  64. Lagarde A, Spinelli S, Tegoni M, He X, Field L, Zhou J, et al. The crystal structure of odorant binding protein 7 from Anopheles gambiae exhibits an outstanding adaptability of its binding site. J Mol Biol. 2011;414:401-12 pubmed publisher
    ..The structure of AgamOBP07 in complex with an azo-bicyclic model compound reveals that a large conformational change in the protein has reshaped its binding site, provoking helix 4 unfolding and doubling of the cavity volume...
  65. Protopopoff N, Verhaeghen K, Van Bortel W, Roelants P, Marcotty T, Baza D, et al. A significant increase in kdr in Anopheles gambiae is associated with an intensive vector control intervention in Burundi highlands. Trop Med Int Health. 2008;13:1479-87 pubmed publisher
    ..However, the high occurrence of the kdr mutation, even at sites far from the sprayed areas, suggests a selection pressure other than that exerted by the vector control programme...
  66. Kang S, Sim C, Byrd B, Collins F, Hong Y. Ex vivo promoter analysis of antiviral heat shock cognate 70B gene in Anopheles gambiae. Virol J. 2008;5:136 pubmed publisher
    ..Induction by three taxonomically distinct arboviruses suggests that the HSC70B protein may be expressed to cope with cellular stress imposed during infection...
  67. González Lázaro M, Dinglasan R, Hernández Hernández F, RODRIGUEZ M, Laclaustra M, Jacobs Lorena M, et al. Anopheles gambiae Croquemort SCRBQ2, expression profile in the mosquito and its potential interaction with the malaria parasite Plasmodium berghei. Insect Biochem Mol Biol. 2009;39:395-402 pubmed publisher
    ..Interestingly, knockdown of SCRBQ2 expression by dsRNA injection resulted in a 62.5% inhibition of oocyst formation, suggesting that SCRBQ2 plays a role in Plasmodium-mosquito interactions. ..
  68. Meleshkevitch E, Robinson M, Popova L, Miller M, Harvey W, Boudko D. Cloning and functional expression of the first eukaryotic Na+-tryptophan symporter, AgNAT6. J Exp Biol. 2009;212:1559-67 pubmed publisher