European honey bee

Summary

Alias: Western honey bee, bee, honey bee, honeybee, Apis mellifera, Apis mellifica, Apis mellifera Linnaeus, 1758

Top Publications

  1. Grohmann L, Blenau W, Erber J, Ebert P, Str nker T, Baumann A. Molecular and functional characterization of an octopamine receptor from honeybee (Apis mellifera) brain. J Neurochem. 2003;86:725-35 pubmed
    ..Here we report the cloning and functional characterization of the first octopamine receptor from the honeybee, Apis mellifera. The gene was isolated from a brain-specific cDNA library...
  2. Kucharski R, Ball E, Hayward D, Maleszka R. Molecular cloning and expression analysis of a cDNA encoding a glutamate transporter in the honeybee brain. Gene. 2000;242:399-405 pubmed
    ..and characterized a cDNA encoding a putative glutamate transporter, Am-EAAT, from the brain of the honeybee, Apis mellifera. The 543-amino-acid AmEAAT gene product shares the highest sequence identity (54%) with the human EAAT2 ..
  3. Corona M, Hughes K, Weaver D, Robinson G. Gene expression patterns associated with queen honey bee longevity. Mech Ageing Dev. 2005;126:1230-8 pubmed
    ..We explored these possibilities in the honey bee, a good model for the study of aging because it has a caste system in which the same genome produces both a long-..
  4. Seehuus S, Norberg K, Krekling T, Fondrk K, Amdam G. Immunogold localization of vitellogenin in the ovaries, hypopharyngeal glands and head fat bodies of honeybee workers, Apis mellifera. J Insect Sci. 2007;7:1-14 pubmed publisher
    Vitellogenin is a yolk precursor protein in most oviparous females. In the advanced eusocial honeybee, Apis mellifera (Hymenoptera: Apidae), vitellogenin has recently attracted much interest as this protein, in addition to a classical ..
  5. Soares M, Silva Torres F, Elias Neto M, Nunes F, Sim es Z, Bitondi M. Ecdysteroid-dependent expression of the tweedle and peroxidase genes during adult cuticle formation in the honey bee, Apis mellifera. PLoS ONE. 2011;6:e20513 pubmed publisher
    ..AmelTwdl2, and a gene encoding a cuticle peroxidase containing the Animal haem peroxidase domain, Ampxd, in the honey bee. Gene sequencing and annotation validated the formerly predicted tweedle genes, and revealed a novel gene, Ampxd,..
  6. Kucharski R, Maleszka R. Arginine kinase is highly expressed in the compound eye of the honey bee, Apis mellifera. Gene. 1998;211:343-9 pubmed
    We have cloned and sequenced a 1.68-kb cDNA encoding arginine kinase in the honey bee, Apis mellifera. The predicted protein shows a high level of identity to known arginine kinases in invertebrates and to other proteins belonging to the ..
  7. Sawata M, Yoshino D, Takeuchi H, Kamikouchi A, Ohashi K, Kubo T. Identification and punctate nuclear localization of a novel noncoding RNA, Ks-1, from the honeybee brain. RNA. 2002;8:772-85 pubmed
    We identified a novel gene, Ks-1, which is expressed preferentially in the small-type Kenyon cells of the honeybee brain. This gene is also expressed in some of the large soma neurons in the brain and in the suboesophageal ganglion...
  8. Kamikouchi A, Takeuchi H, Sawata M, Ohashi K, Natori S, Kubo T. Preferential expression of the gene for a putative inositol 1,4,5-trisphosphate receptor homologue in the mushroom bodies of the brain of the worker honeybee Apis mellifera L. Biochem Biophys Res Commun. 1998;242:181-6 pubmed publisher
    A gene expressed preferentially in the mushroom bodies of the brain of the worker honeybee Apis mellifera L. was identified by the differential display method and its cDNA was isolated...
  9. Maier D, Chen A, Preiss A, Ketelhut M. The tiny Hairless protein from Apis mellifera: a potent antagonist of Notch signaling in Drosophila melanogaster. BMC Evol Biol. 2008;8:175 pubmed publisher
    ..To further our understanding of Hairless structure and function, we have cloned the Hairless gene from Apis mellifera (A.m.H) and characterized its functional conservation in Drosophila. ..

More Information

Publications137 found, 100 shown here

  1. Malecov B, Ramser J, O Brien J, Janitz M, J dov J, Lehrach H, et al. Honeybee (Apis mellifera L.) mrjp gene family: computational analysis of putative promoters and genomic structure of mrjp1, the gene coding for the most abundant protein of larval food. Gene. 2003;303:165-75 pubmed
    Mrjp1 gene belongs to the honeybee mrjp gene family encoding the major royal jelly proteins (MRJPs), secreted by nurse bees into the royal jelly...
  2. Piulachs M, Guidugli K, Barchuk A, Cruz J, Simões Z, Belles X. The vitellogenin of the honey bee, Apis mellifera: structural analysis of the cDNA and expression studies. Insect Biochem Mol Biol. 2003;33:459-65 pubmed
    The cDNA of Apis mellifera vitellogenin was cloned and sequenced. It is 5440 bp long and contains an ORF of 1770 amino acids (including a putative signal peptide of 16 residues)...
  3. Cunha A, Nascimento A, Guidugli K, Sim es Z, Bitondi M. Molecular cloning and expression of a hexamerin cDNA from the honey bee, Apis mellifera. J Insect Physiol. 2005;51:1135-47 pubmed publisher
    A cDNA encoding a hexamerin subunit of the Africanized honey bee (Apis mellifera) was isolated and completely sequenced. In the deduced translation product we identified the N-terminal sequence typical of the honey bee HEX 70b hexamerin...
  4. Tares S, Berge J, Amichot M. Cloning and expression of cytochrome P450 genes belonging to the CYP4 family and to a novel family, CYP48, in two hymenopteran insects, Trichogramma cacoeciae and Apis mellifera. Biochem Biophys Res Commun. 2000;268:677-82 pubmed
    ..DNA from two hymenopteran insects of agronomical importance, Trichogramma cacoeciae, a parasitoid wasp, and Apis mellifera, the honeybee...
  5. Liao Z, Jia Q, Li F, Han Z. Identification of two piwi genes and their expression profile in honeybee, Apis mellifera. Arch Insect Biochem Physiol. 2010;74:91-102 pubmed publisher
    ..However, these genes are not well understood in most insects. To understand the function of piwi genes in honeybee reproduction, we amplified two full-length piwi-like genes, Am-aub and Am-ago3...
  6. Lee J, Tsuji M, Nakamura M, Nishimoto M, Okuyama M, Mori H, et al. Purification and identification of the essential ionizable groups of honeybee, Apis mellifera L., trehalase. Biosci Biotechnol Biochem. 2001;65:2657-65 pubmed
    ..5 kcal/mol. These findings strongly support the notion that the essential ionizable groups of honeybee trehalase are two kinds of carboxyl groups, one being a dissociated type (-COO(-), ionizable group 1) and the ..
  7. Ben Shahar Y, Robichon A, Sokolowski M, Robinson G. Influence of gene action across different time scales on behavior. Science. 2002;296:741-4 pubmed
    ..Previous research showed that allelic differences in PKG expression result in two Drosophila foraging variants. The same gene can thus exert different types of influence on a behavior. ..
  8. Huising M, Flik G. The remarkable conservation of corticotropin-releasing hormone (CRH)-binding protein in the honeybee (Apis mellifera) dates the CRH system to a common ancestor of insects and vertebrates. Endocrinology. 2005;146:2165-70 pubmed publisher
    ..Here we report the presence of CRH-BP in the honeybee (Apis mellifera) and other insects...
  9. Guidugli K, Nascimento A, Amdam G, Barchuk A, Omholt S, Simoes Z, et al. Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect. FEBS Lett. 2005;579:4961-5 pubmed
    Functionally sterile honey bee workers synthesize the yolk protein vitellogenin while performing nest tasks. The subsequent shift to foraging is linked to a reduced vitellogenin and an increased juvenile hormone (JH) titer...
  10. Hoffman D. Hymenoptera venom allergens. Clin Rev Allergy Immunol. 2006;30:109-28 pubmed
    ..Examples of the use of these techniques with venom proteins are presented. ..
  11. Li W, Huang Z, Liu F, Li Z, Yan L, Zhang S, et al. Molecular cloning and characterization of juvenile hormone acid methyltransferase in the honey bee, Apis mellifera, and its differential expression during caste differentiation. PLoS ONE. 2013;8:e68544 pubmed publisher
    ..We used RACE amplification method to clone JHAMT cDNA from the honey bee, Apis mellifera (AmJHAMT)...
  12. Ohashi K, Natori S, Kubo T. Expression of amylase and glucose oxidase in the hypopharyngeal gland with an age-dependent role change of the worker honeybee (Apis mellifera L.). Eur J Biochem. 1999;265:127-33 pubmed
    ..We have isolated cDNA clones for two honeybee (Apis mellifera L...
  13. Collins A, Williams V, Evans J. Sperm storage and antioxidative enzyme expression in the honey bee, Apis mellifera. Insect Mol Biol. 2004;13:141-6 pubmed
    Honey bee (Apis mellifera) sperm remains viable in the spermatheca of mated female honey bees for several years...
  14. Kubota M, Tsuji M, Nishimoto M, Wongchawalit J, Okuyama M, Mori H, et al. Localization of alpha-glucosidases I, II, and III in organs of European honeybees, Apis mellifera L., and the origin of alpha-glucosidase in honey. Biosci Biotechnol Biochem. 2004;68:2346-52 pubmed
    Three kinds of alpha-glucosidases, I, II, and III, were purified from European honeybees, Apis mellifera L. In addition, an alpha-glucosidase was also purified from honey...
  15. Louren o A, Zufelato M, Bitondi M, Sim es Z. Molecular characterization of a cDNA encoding prophenoloxidase and its expression in Apis mellifera. Insect Biochem Mol Biol. 2005;35:541-52 pubmed publisher
    ..We characterized the first proPO cDNA in an eusocial insect, the Apis mellifera honey bee...
  16. Kamakura M. Royalactin induces queen differentiation in honeybees. Nature. 2011;473:478-83 pubmed publisher
    The honeybee (Apis mellifera) forms two female castes: the queen and the worker...
  17. Casteels P, Ampe C, Riviere L, Van Damme J, Elicone C, Fleming M, et al. Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera). Eur J Biochem. 1990;187:381-6 pubmed
    Honeybee (Apis mellifera) are frequently exposed to and likely to be infected by plant-associated bacteria...
  18. Danty E, Arnold G, Huet J, Huet D, Masson C, Pernollet J. Separation, characterization and sexual heterogeneity of multiple putative odorant-binding proteins in the honeybee Apis mellifera L. (Hymenoptera: Apidea). Chem Senses. 1998;23:83-91 pubmed
    ..Genotype comparison of two honeybee races revealed a variability limited to this second class...
  19. Walldorf U, Binner P, Fleig R. Hox genes in the honey bee Apis mellifera. Dev Genes Evol. 2000;210:483-92 pubmed
    ..Sex combs reduced (Scr), Antennapedia (Antp), and Ultrabithorax/abdominal-A (Ubx/abd-A) from the honey bee Apis mellifera. We also cloned a cDNA with the complete coding region of the Antennapedia gene from Apis...
  20. Ben Shahar Y, Leung H, Pak W, Sokolowski M, Robinson G. cGMP-dependent changes in phototaxis: a possible role for the foraging gene in honey bee division of labor. J Exp Biol. 2003;206:2507-15 pubmed
    Division of labor in honey bee colonies is influenced by the foraging gene (Amfor), which encodes a cGMP-dependent protein kinase (PKG)...
  21. Paul R, Takeuchi H, Matsuo Y, Kubo T. Gene expression of ecdysteroid-regulated gene E74 of the honeybee in ovary and brain. Insect Mol Biol. 2005;14:9-15 pubmed
    To facilitate studies of hormonal control in the honeybee (Apis mellifera L.), a cDNA for a honeybee homologue of the ecdysteroid-regulated gene E74 (AmE74) was isolated and its expression was analysed...
  22. For t S, Maleszka R. Function and evolution of a gene family encoding odorant binding-like proteins in a social insect, the honey bee (Apis mellifera). Genome Res. 2006;16:1404-13 pubmed publisher
    ..and experimental approaches to characterize the OBP-like gene family in a highly social insect, the Western honey bee. Comparison with other insects shows that the honey bee has the smallest set of these genes, consisting of ..
  23. Louis T, Musso P, de Oliveira S, Garreau L, Giurfa M, Raymond V, et al. Amel?8 subunit knockdown in the mushroom body vertical lobes impairs olfactory retrieval in the honeybee, Apis mellifera. Eur J Neurosci. 2012;36:3438-50 pubmed publisher
    ..of the ?8 subunit of nicotinic acetylcholine receptors (nAChRs) in olfactory learning and memory in Apis mellifera. We have previously shown, by injecting different nicotinic antagonists into the bee brain, that ..
  24. Evans J, Wheeler D. Differential gene expression between developing queens and workers in the honey bee, Apis mellifera. Proc Natl Acad Sci U S A. 1999;96:5575-80 pubmed
    ..approach for studying queen- and worker-specific gene expression in the development of the honey bee (Apis mellifera). Numerous genes appear to be differentially expressed between the two castes...
  25. Bania J, Stachowiak D, Polanowski A. Primary structure and properties of the cathepsin G/chymotrypsin inhibitor from the larval hemolymph of Apis mellifera. Eur J Biochem. 1999;262:680-7 pubmed
    ..anti-cathepsin G and anti-chymotrypsin activity was purified from the larval hemolymph of the honey bee (Apis mellifera)...
  26. Thany S, Lenaers G, Crozatier M, Armengaud C, Gauthier M. Identification and localization of the nicotinic acetylcholine receptor alpha3 mRNA in the brain of the honeybee, Apis mellifera. Insect Mol Biol. 2003;12:255-62 pubmed
    ..In the honeybee Apis mellifera, pharmacological and electrophysiological studies have shown that different nicotinic acetylcholine receptor ..
  27. Si A, Helliwell P, Maleszka R. Effects of NMDA receptor antagonists on olfactory learning and memory in the honeybee (Apis mellifera). Pharmacol Biochem Behav. 2004;77:191-7 pubmed
    ..antagonists, memantine (low affinity) and MK-801 (high affinity), on learning and memory in honeybees (Apis mellifera) using the olfactory conditioning of the proboscis extension reflex (PER)...
  28. Albert S, Klaudiny J. The MRJP/YELLOW protein family of Apis mellifera: identification of new members in the EST library. J Insect Physiol. 2004;50:51-9 pubmed publisher
    Major royal jelly proteins (named MRJP1-5) of honeybee (Apis mellifera), yellow proteins of Drosophila, together with putative proteins found in several bacteria, form a protein family termed the MRJP/yellow family...
  29. Seehuus S, Norberg K, Gimsa U, Krekling T, Amdam G. Reproductive protein protects functionally sterile honey bee workers from oxidative stress. Proc Natl Acad Sci U S A. 2006;103:962-7 pubmed
    ..Here, we studied a circuit of aging in the honey bee (Apis mellifera)...
  30. Jones A, Raymond Delpech V, Thany S, Gauthier M, Sattelle D. The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera. Genome Res. 2006;16:1422-30 pubmed
    ..The honey bee, Apis mellifera, is one of the most beneficial insects worldwide, playing an important role in crop pollination, and is also a ..
  31. Maleszka J, For t S, Saint R, Maleszka R. RNAi-induced phenotypes suggest a novel role for a chemosensory protein CSP5 in the development of embryonic integument in the honeybee (Apis mellifera). Dev Genes Evol. 2007;217:189-96 pubmed publisher
    ..of genome annotation, transcriptional profiling and RNA interference to unravel the functional significance of a honeybee gene (csp5) belonging to the CSP family...
  32. Nichols Z, Vogt R. The SNMP/CD36 gene family in Diptera, Hymenoptera and Coleoptera: Drosophila melanogaster, D. pseudoobscura, Anopheles gambiae, Aedes aegypti, Apis mellifera, and Tribolium castaneum. Insect Biochem Mol Biol. 2008;38:398-415 pubmed publisher
    ..pseudoobscura, Anopheles gambiae and Aedes aegypti (Diptera), eight candidate homologs from Apis mellifera (Hymenoptera), and 15 from Tribolium castaneum (Coleoptera)...
  33. de Azevedo S, Hartfelder K. The insulin signaling pathway in honey bee (Apis mellifera) caste development - differential expression of insulin-like peptides and insulin receptors in queen and worker larvae. J Insect Physiol. 2008;54:1064-71 pubmed publisher
    ..insulin-like peptides (AmILP-1 and AmILP-2) and the two insulin receptors (AmInR-1 and AmInR-2) predicted in the honey bee genome...
  34. Ohashi K, Sawata M, Takeuchi H, Natori S, Kubo T. Molecular cloning of cDNA and analysis of expression of the gene for alpha-glucosidase from the hypopharyngeal gland of the honeybee Apis mellifera L. Biochem Biophys Res Commun. 1996;221:380-5 pubmed publisher
    ..a molecular mass of 70 kDa from a homogenate of the hypopharyngeal gland of the older worker bee (forager bee) Apis mellifera L. (T. Kubo et al, J. Biochem., 1996, 119, 291-295)...
  35. Krieger J, Klink O, Mohl C, Raming K, Breer H. A candidate olfactory receptor subtype highly conserved across different insect orders. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2003;189:519-26 pubmed
    ..In addition, based on RT-PCR experiments HR2 homologues were discovered in antennal cDNA of the honey bee (Apis mellifera; Hymenoptera), the blowfly (Calliphora erythrocephala; Diptera) and the mealworm (Tenebrio molitor; Coleoptera)..
  36. do Nascimento A, Cuvillier Hot V, Barchuk A, Simões Z, Hartfelder K. Honey bee (Apis mellifera) transferrin-gene structure and the role of ecdysteroids in the developmental regulation of its expression. Insect Biochem Mol Biol. 2004;34:415-24 pubmed
    ..In this study, we isolated cDNA and genomic clones encoding an Apis mellifera transferrin (AmTRF) gene. It has an open reading frame (ORF) of 2136 bp spread over nine exons...
  37. Lee J, Saito S, Mori H, Nishimoto M, Okuyama M, Kim D, et al. Molecular cloning of cDNA for trehalase from the European honeybee, Apis mellifera L., and its heterologous expression in Pichia pastoris. Biosci Biotechnol Biochem. 2007;71:2256-65 pubmed publisher
    cDNA encoding the bound type trehalase of the European honeybee was cloned...
  38. Cho S, Huang Z, Zhang J. Sex-specific splicing of the honeybee doublesex gene reveals 300 million years of evolution at the bottom of the insect sex-determination pathway. Genetics. 2007;177:1733-41 pubmed
    ..To address these questions, here we study the dsx gene of the honeybee Apis mellifera, a member of the most basal lineage of holometabolous insects...
  39. Beye M, Hasselmann M, Fondrk M, Page R, Omholt S. The gene csd is the primary signal for sexual development in the honeybee and encodes an SR-type protein. Cell. 2003;114:419-29 pubmed
    ..We have dissected the complementary sex determiner (csd) locus in the honeybee to understand its molecular basis...
  40. Mustard J, Kurshan P, Hamilton I, Blenau W, Mercer A. Developmental expression of a tyramine receptor gene in the brain of the honey bee, Apis mellifera. J Comp Neurol. 2005;483:66-75 pubmed publisher
    ..receptor gene, Amtyr1, is expressed in the developing brain, as well as in the brain of the adult worker honey bee. Changes in levels of Amtyr1 expression were examined using Northern analysis...
  41. Shipman B, Ryan R, Schmidt J, Law J. Purification and properties of a very high density lipoprotein from the hemolymph of the honeybee Apis mellifera. Biochemistry. 1987;26:1885-9 pubmed
    A larval-specific very high density lipoprotein (VHDL) has been isolated from the hemolymph of the honeybee Apis mellifera. VHDL was isolated by a combination of density gradient ultracentrifugation and gel filtration...
  42. Blenau W, Erber J, Baumann A. Characterization of a dopamine D1 receptor from Apis mellifera: cloning, functional expression, pharmacology, and mRNA localization in the brain. J Neurochem. 1998;70:15-23 pubmed
    ..We have isolated a homologue of the vertebrate dopamine D1 receptor subfamily from the honeybee Apis mellifera. [3H]Lysergic acid diethylamide specifically binds to the heterologously expressed receptor with K(D) ..
  43. Blenau W, Balfanz S, Baumann A. Amtyr1: characterization of a gene from honeybee (Apis mellifera) brain encoding a functional tyramine receptor. J Neurochem. 2000;74:900-8 pubmed
    ..We have cloned a member of this gene family from the CNS of the honeybee, Apis mellifera. The deduced amino acid sequence is homologous to tyramine receptors cloned from Locusta migratoria and ..
  44. Kamikouchi A, Takeuchi H, Sawata M, Natori S, Kubo T. Concentrated expression of Ca2+/ calmodulin-dependent protein kinase II and protein kinase C in the mushroom bodies of the brain of the honeybee Apis mellifera L. J Comp Neurol. 2000;417:501-10 pubmed publisher
    ..involved in the intracellular Ca2+ signal transduction is also concentrated in the mushroom bodies of the honeybee by isolating cDNA fragments that encode the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and protein ..
  45. B likov K, Hanes J, Nordhoff E, Saenger W, Klaudiny J, Sim th J. Apisimin, a new serine-valine-rich peptide from honeybee (Apis mellifera L.) royal jelly: purification and molecular characterization. FEBS Lett. 2002;528:125-9 pubmed
    A peptide named apisimin was found in honeybee (Apis mellifera L.) royal jelly (RJ)...
  46. Sawata M, Takeuchi H, Kubo T. Identification and analysis of the minimal promoter activity of a novel noncoding nuclear RNA gene, AncR-1, from the honeybee (Apis mellifera L.). RNA. 2004;10:1047-58 pubmed publisher
    ..for a noncoding nuclear RNA, termed Ks-1, that is expressed preferentially in a restricted set of neurons in the honeybee brain...
  47. Vidovic M, Nighorn A, Koblar S, Maleszka R. Eph receptor and ephrin signaling in developing and adult brain of the honeybee (Apis mellifera). Dev Neurobiol. 2007;67:233-51 pubmed
    ..Here, we report on the characterization of Eph receptor and ephrin orthologs in the honeybee, Apis mellifera (Am), and their role in learning and memory...
  48. Takeuchi H, Paul R, Matsuzaka E, Kubo T. EcR-A expression in the brain and ovary of the honeybee (Apis mellifera L.). Zoolog Sci. 2007;24:596-603 pubmed publisher
    ..signaling are expressed preferentially in Kenyon-cell subtypes in the mushroom bodies of the honeybee (Apis mellifera L.)...
  49. Marco Antonio D, Guidugli Lazzarini K, do Nascimento A, Simões Z, Hartfelder K. RNAi-mediated silencing of vitellogenin gene function turns honeybee (Apis mellifera) workers into extremely precocious foragers. Naturwissenschaften. 2008;95:953-61 pubmed publisher
    ..switch from within-hive activities to foraging behavior is a major transition in the life cycle of a honeybee (Apis mellifera) worker...
  50. Gempe T, Hasselmann M, Schiøtt M, Hause G, Otte M, Beye M. Sex determination in honeybees: two separate mechanisms induce and maintain the female pathway. PLoS Biol. 2009;7:e1000222 pubmed publisher
    Organisms have evolved a bewildering diversity of mechanisms to generate the two sexes. The honeybee (Apis mellifera) employs an interesting system in which sex is determined by heterozygosity at a single locus (the Sex Determination ..
  51. Kent C, Issa A, Bunting A, Zayed A. Adaptive evolution of a key gene affecting queen and worker traits in the honey bee, Apis mellifera. Mol Ecol. 2011;20:5226-35 pubmed publisher
    ..egg yolk precursor protein represents a well-studied case of social pleiotropy in the model organism Apis mellifera. Vitellogenin is associated with fecundity in queens and plays a major role in controlling division of labour ..
  52. Gmachl M, Kreil G. The precursors of the bee venom constituents apamin and MCD peptide are encoded by two genes in tandem which share the same 3'-exon. J Biol Chem. 1995;270:12704-8 pubmed
    ..Both cDNAs encode unusually small precursors comprising only 46 amino acids in case of apamin and 50 in the case of the MCD peptide. ..
  53. Casteels P, Ampe C, Jacobs F, Tempst P. Functional and chemical characterization of Hymenoptaecin, an antibacterial polypeptide that is infection-inducible in the honeybee (Apis mellifera). J Biol Chem. 1993;268:7044-54 pubmed
    ..In combination, the six-constituent "peptide antibiotics" of bee lymph provide wide-spectrum antibacterial protection in vitro by virtue of complementarity rather than synergism.
  54. Bellingham J, Wilkie S, Morris A, Bowmaker J, Hunt D. Characterisation of the ultraviolet-sensitive opsin gene in the honey bee, Apis mellifera. Eur J Biochem. 1997;243:775-81 pubmed
    The cDNA sequence of the ultraviolet-sensitive opsin in the honey-bee, Apis mellifera, with associated 5' and 3' untranslated regions, is presented...
  55. Kettner A, Hughes G, Frutiger S, Astori M, Roggero M, Spertini F, et al. Api m 6: a new bee venom allergen. J Allergy Clin Immunol. 2001;107:914-20 pubmed
    ..The purpose of this study was the identification and characterization of a low-molecular-weight, IgE-binding, bee venom (BV) allergen. BV proteins were separated by using size exclusion chromatography and HPLC...
  56. Takeuchi H, Fujiyuki T, Shirai K, Matsuo Y, Kamikouchi A, Fujinawa Y, et al. Identification of genes expressed preferentially in the honeybee mushroom bodies by combination of differential display and cDNA microarray. FEBS Lett. 2002;513:230-4 pubmed
    To clarify the molecular basis underlying the neural function of the honeybee mushroom bodies (MBs), we identified three genes preferentially expressed in MB using cDNA microarrays containing 480 differential display-positive candidate ..
  57. Gisselmann G, Warnstedt M, Gamerschlag B, Bormann A, Marx T, Neuhaus E, et al. Characterization of recombinant and native Ih-channels from Apis mellifera. Insect Biochem Mol Biol. 2003;33:1123-34 pubmed
    ..We isolated a cDNA (AMIH) encoding a putative member of these ion channels from Apis mellifera heads by means of polymerase chain reaction and homology screening...
  58. Petryk A, Warren J, Marques G, Jarcho M, Gilbert L, Kahler J, et al. Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone. Proc Natl Acad Sci U S A. 2003;100:13773-8 pubmed
  59. Kamikouchi A, Morioka M, Kubo T. Identification of honeybee antennal proteins/genes expressed in a sex- and/or caste selective manner. Zoolog Sci. 2004;21:53-62 pubmed
    ..three candidate proteins/genes involved in caste and/or sex-specific olfactory processing in the honeybee Apis mellifera L...
  60. Kucharski R, Maleszka R. Transcriptional profiling reveals multifunctional roles for transferrin in the honeybee, Apis mellifera. J Insect Sci. 2003;3:27 pubmed
    ..have sequenced and characterized a full-length cDNA encoding a putative iron-binding transferrin (AmTRF) in the honeybee. AmTRF shows high level of sequence identity with transferrins in both vertebrates and insects (26-46%) ..
  61. Beggs K, Hamilton I, Kurshan P, Mustard J, Mercer A. Characterization of a D2-like dopamine receptor (AmDOP3) in honey bee, Apis mellifera. Insect Biochem Mol Biol. 2005;35:873-82 pubmed publisher
    ..in vertebrate and invertebrate nervous systems and is widely distributed in the brain of the honey bee, Apis mellifera. We report here the functional characterization and cellular localization of the putative dopamine receptor ..
  62. Jones A, Sattelle D. The cys-loop ligand-gated ion channel superfamily of the honeybee, Apis mellifera. Invert Neurosci. 2006;6:123-32 pubmed publisher
    ..We have described the cys-loop LGIC superfamily of the honeybee, Apis mellifera, which is an important crop pollinator and a key model for social interaction...
  63. Hagai T, Cohen M, Bloch G. Genes encoding putative Takeout/juvenile hormone binding proteins in the honeybee (Apis mellifera) and modulation by age and juvenile hormone of the takeout-like gene GB19811. Insect Biochem Mol Biol. 2007;37:689-701 pubmed publisher
    ..and characterized eight genes encoding putative Takeout/juvenile hormone binding proteins (To/JHBP) in the honeybee genome...
  64. Fussnecker B, Grozinger C. Dissecting the role of Kr-h1 brain gene expression in foraging behavior in honey bees (Apis mellifera). Insect Mol Biol. 2008;17:515-22 pubmed publisher
    Expression of Krüppel homolog-1 (Kr-h1) in the honey bee brain is strongly associated with foraging behavior. We performed a series of studies to determine if Kr-h1 expression correlates with specific aspects of foraging...
  65. Danty E, Michard Vanh e C, Huet J, Genecque E, Pernollet J, Masson C. Biochemical characterization, molecular cloning and localization of a putative odorant-binding protein in the honey bee Apis mellifera L. (Hymenoptera : Apidea). FEBS Lett. 1997;414:595-8 pubmed
    A honey bee antennal water-soluble protein, APS2, was purified and characterized as the first Hymenoptera putative odorant-binding protein. Comparison of its measured Mr (13695.2+/-1...
  66. Tsuchimoto M, Aoki M, Takada M, Kanou Y, Sasagawa H, Kitagawa Y, et al. The changes of gene expression in honeybee (Apis mellifera) brains associated with ages. Zoolog Sci. 2004;21:23-8 pubmed publisher
    Honeybee (Apis mellifera) worker bees (workers) are known to perform wide variety of tasks depending on their ages. The worker's brains also show the activity and behavior-dependent chemical and structural plasticity...
  67. Fontana R, Mendes M, de Souza B, Konno K, C sar L, Malaspina O, et al. Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera). Peptides. 2004;25:919-28 pubmed publisher
    ..These peptides do not present any similarity with the other antimicrobial peptides from the honeybees; they are produced constitutively by the workers and secreted into Royal Jelly...
  68. Robertson H, Gordon K. Canonical TTAGG-repeat telomeres and telomerase in the honey bee, Apis mellifera. Genome Res. 2006;16:1345-51 pubmed publisher
    The draft assembly of the honey bee Apis mellifera genome sequence reveals that the 17 centromeric-distal telomeres are of a simple, shared, and canonical structure, with 3-4 kb of a unique subtelomeric sequence, followed by several ..
  69. Biswas S, Russell R, Jackson C, Vidovic M, Ganeshina O, Oakeshott J, et al. Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera. PLoS ONE. 2008;3:e3542 pubmed publisher
    ..Here we report a genetic analysis of homologous proteins in the honey bee. As in humans, the honeybee has five large (31-246 kb, up to 12 exons each) neuroligin genes, three of which are ..
  70. Shapira M, Thompson C, Soreq H, Robinson G. Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee colonies. J Mol Neurosci. 2001;17:1-12 pubmed
    Division of labor in honey bee colonies is highlighted by adult bees making a transition at 2-3 wk of age from working in the hive to foraging for nectar and pollen outside...
  71. Takeuchi H, Kage E, Sawata M, Kamikouchi A, Ohashi K, Ohara M, et al. Identification of a novel gene, Mblk-1, that encodes a putative transcription factor expressed preferentially in the large-type Kenyon cells of the honeybee brain. Insect Mol Biol. 2001;10:487-94 pubmed
    ..To identify the genes involved in the intrinsic function of the honeybee MBs, we searched for genes preferentially expressed therein, using the differential display method...
  72. Takeuchi H, Yasuda A, Yasuda Kamatani Y, Kubo T, Nakajima T. Identification of a tachykinin-related neuropeptide from the honeybee brain using direct MALDI-TOF MS and its gene expression in worker, queen and drone heads. Insect Mol Biol. 2003;12:291-8 pubmed
    ..we identified and determined the amino acid sequence of a novel neuropeptide in the brain of the honeybee Apis mellifera L., termed AmTRP peptide (Apis mellifera tachykinin-related peptide), related to insect tachykinin...
  73. Lehman H, Schulz D, Barron A, Wraight L, Hardison C, Whitney S, et al. Division of labor in the honey bee (Apis mellifera): the role of tyramine beta-hydroxylase. J Exp Biol. 2006;209:2774-84 pubmed publisher
    The biogenic amine octopamine (OA) is involved in the regulation of honey bee behavioral development; brain levels are higher in foragers than bees working in the hive, especially in the antennal lobes, and treatment causes precocious ..
  74. Dearden P, Wilson M, Sablan L, Osborne P, Havler M, McNaughton E, et al. Patterns of conservation and change in honey bee developmental genes. Genome Res. 2006;16:1376-84 pubmed
    ..paper we examine the conservation and divergence of genes and developmental processes between Drosophila and the honey bee; two holometabolous insects whose lineages separated approximately 300 million years ago, by comparing the ..
  75. Rubin E, Shemesh Y, Cohen M, Elgavish S, Robertson H, Bloch G. Molecular and phylogenetic analyses reveal mammalian-like clockwork in the honey bee (Apis mellifera) and shed new light on the molecular evolution of the circadian clock. Genome Res. 2006;16:1352-65 pubmed publisher
    The circadian clock of the honey bee is implicated in ecologically relevant complex behaviors...
  76. Kucharski R, Mitri C, Grau Y, Maleszka R. Characterization of a metabotropic glutamate receptor in the honeybee (Apis mellifera): implications for memory formation. Invert Neurosci. 2007;7:99-108 pubmed
    ..Here we characterised a member of this family in the honeybee. We show that the honeybee genome encodes a genuine mGluR (AmGluRA) that is expressed at low to medium levels in ..
  77. de Graaf D, Brunain M, Scharlaken B, Peiren N, Devreese B, Ebo D, et al. Two novel proteins expressed by the venom glands of Apis mellifera and Nasonia vitripennis share an ancient C1q-like domain. Insect Mol Biol. 2010;19 Suppl 1:1-10 pubmed publisher
    ..study of previously unidentified two-dimensional polyacrylamide gel electrophoresis spots of honey bee (Apis mellifera, Hymenoptera) venom revealed a new protein with a C1q conserved domain (C1q-VP)...
  78. Uno Y, Fujiyuki T, Morioka M, Kubo T. Mushroom body-preferential expression of proteins/genes involved in endoplasmic reticulum Ca(2+)-transport in the worker honeybee (Apis mellifera L.) brain. Insect Mol Biol. 2013;22:52-61 pubmed publisher
    ..the molecular characteristics specific to the mushroom body (MB, a higher processing centre) neurones in the honeybee brain, we previously used proteomics to identify proteins that are preferentially expressed in these MBs...
  79. Kubo T, Sasaki M, Nakamura J, Sasagawa H, Ohashi K, Takeuchi H, et al. Change in the expression of hypopharyngeal-gland proteins of the worker honeybees (Apis mellifera L.) with age and/or role. J Biochem. 1996;119:291-5 pubmed
    The roles of adult worker honeybees change with age; young workers nurse brood by secreting bee milk (royal jelly), and older workers forage for nectar and pollen and process nectar into honey...
  80. Ohashi K, Natori S, Kubo T. Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L. Eur J Biochem. 1997;249:797-802 pubmed
    Major proteins synthesized in the hypopharyngeal gland of the worker honeybee change from bee-milk proteins to alpha-glucosidase in accordance with the age-dependent role change of the worker bee...
  81. Eisenhardt D, Fiala A, Braun P, Rosenboom H, Kress H, Ebert P, et al. Cloning of a catalytic subunit of cAMP-dependent protein kinase from the honeybee (Apis mellifera) and its localization in the brain. Insect Mol Biol. 2001;10:173-81 pubmed
    In the honeybee the cAMP-dependent signal transduction cascade has been implicated in processes underlying learning and memory. The cAMP-dependent protein kinase (PKA) is the major mediator of cAMP action...
  82. Kucharski R, Maleszka R. Molecular profiling of behavioural development: differential expression of mRNAs for inositol 1,4,5-trisphosphate 3-kinase isoforms in naive and experienced honeybees (Apis mellifera). Brain Res Mol Brain Res. 2002;99:92-101 pubmed
    ..DNA sequencing yielded a contig of 21.5 kb spanning the honeybee IP(3)K locus and a 3' flanking gene similar to a transcription factor NFR-kappa-B...
  83. Farooqui T, Vaessin H, Smith B. Octopamine receptors in the honeybee (Apis mellifera) brain and their disruption by RNA-mediated interference. J Insect Physiol. 2004;50:701-13 pubmed publisher
    Octopamine plays important neuromodulatory roles in the honeybee brain. Accordingly, mRNA from a recently identified honeybee octopamine receptor (AmOA1) is distributed throughout the brain...
  84. Barchuk A, Maleszka R, Sim es Z. Apis mellifera ultraspiracle: cDNA sequence and rapid up-regulation by juvenile hormone. Insect Mol Biol. 2004;13:459-67 pubmed publisher
    ..We have cloned and sequenced a cDNA encoding Apis mellifera ultraspiracle (AMUSP) and examined its responses to JH...
  85. Klaudiny J, Albert S, Bachanov K, Kopernick J, Sim th J. Two structurally different defensin genes, one of them encoding a novel defensin isoform, are expressed in honeybee Apis mellifera. Insect Biochem Mol Biol. 2005;35:11-22 pubmed publisher
    Two defensins showing high mutual similarity have previously been characterized in honeybee Apis mellifera: royalisin, a peptide isolated from the royal jelly, and defensin, found in the hemolymph of bacterially infected bees...
  86. Schlenstedt J, Balfanz S, Baumann A, Blenau W. Am5-HT7: molecular and pharmacological characterization of the first serotonin receptor of the honeybee (Apis mellifera). J Neurochem. 2006;98:1985-98 pubmed publisher
    ..We have isolated a cDNA from the honeybee Apis mellifera (Am5-ht7) sharing high similarity to members of the 5-HT(7) receptor family...
  87. Bitondi M, Nascimento A, Cunha A, Guidugli K, Nunes F, Sim es Z. Characterization and expression of the Hex 110 gene encoding a glutamine-rich hexamerin in the honey bee, Apis mellifera. Arch Insect Biochem Physiol. 2006;63:57-72 pubmed publisher
    An N-terminal amino acid sequence of a previously reported honey bee hexamerin, HEX 110 [Danty et al...
  88. Hauser F, Cazzamali G, Williamson M, Blenau W, Grimmelikhuijzen C. A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis mellifera. Prog Neurobiol. 2006;80:1-19 pubmed publisher
    ..to annotate the neurohormone GPCR genes present in the recently sequenced genome from the honey bee Apis mellifera. We found 35 neuropeptide receptor genes in the honey bee (44 in Drosophila) and two genes, coding for leucine-..
  89. Kucharski R, Maleszka J, Maleszka R. Novel cuticular proteins revealed by the honey bee genome. Insect Biochem Mol Biol. 2007;37:128-34 pubmed
    With the completion of the honey bee genome project, a transition is now occurring from the acquisition of gene sequence to understanding the role and context of gene products within the genome...
  90. Hasselmann M, Gempe T, Schi tt M, Nunes Silva C, Otte M, Beye M. Evidence for the evolutionary nascence of a novel sex determination pathway in honeybees. Nature. 2008;454:519-22 pubmed publisher
    Sex determination in honeybees (Apis mellifera) is governed by heterozygosity at a single locus harbouring the complementary sex determiner (csd) gene, in contrast to the well-studied sex chromosome system of Drosophila melanogaster...
  91. Xu P, Xiao J, Xia Q, Murphy B, Huang D. Apis mellifera has two isoforms of cytoplasmic HSP90. Insect Mol Biol. 2010;19:593-7 pubmed publisher
    Unlike most other insects, annotated genomic data suggest that Apis mellifera has two homologous copies of the cytoplasmic gene HSP90...
  92. Teerawanichpan P, Robertson A, Qiu X. A fatty acyl-CoA reductase highly expressed in the head of honey bee (Apis mellifera) involves biosynthesis of a wide range of aliphatic fatty alcohols. Insect Biochem Mol Biol. 2010;40:641-9 pubmed publisher
    Honey bees (Apis mellifera) are social insects which have remarkable complexity in communication pheromones. These chemical signals comprise a mixture of hydrocarbons, wax esters, fatty acids, aldehydes and alcohols...