pig

Summary

Alias: pigs, swine, wild boar, Sus scrofa, Sus scrofa Linnaeus, 1758, Sus scrofus

Top Publications

  1. Sun N, Liu D, Chen H, Liu X, Meng F, Zhang X, et al. Localization, expression change in PRRSV infection and association analysis of the porcine TAP1 gene. Int J Biol Sci. 2012;8:49-58 pubmed
    ..024) of 17 d pigs. Our results showed that the TAP1 gene might have important roles in swine immune responses, and these results provide useful information for further functional studies.
  2. Cirera S, Birck M, Busk P, Fredholm M. Expression profiles of miRNA-122 and its target CAT1 in minipigs (Sus scrofa) fed a high-cholesterol diet. Comp Med. 2010;60:136-41 pubmed
    ..Body weight, total cholesterol, and high-density lipoproteins were higher in pigs fed the high-cholesterol compared with the standard diet...
  3. Zhang C, Yang F, Cornelia R, Tang W, Swisher S, Kim H. Hypoxia-inducible factor-1 is a positive regulator of Sox9 activity in femoral head osteonecrosis. Bone. 2011;48:507-13 pubmed publisher
    ..Hypoxia-inducible factor-1 ? (HIF-1?) is a master regulator of cellular response to hypoxia. A pig model of ischemic osteonecrosis of femoral head has been shown to have radiographic and histopathologic changes ..
  4. Hern ndez Torres F, Rastrojo A, Aguado B. Intron retention and transcript chimerism conserved across mammals: Ly6g5b and Csnk2b-Ly6g5b as examples. BMC Genomics. 2013;14:199 pubmed publisher
    ..Ly6g5b intron retention and Csnk2b-Ly6g5b transcript chimerism are broadly distributed in tissues of different mammals...
  5. Basuroy S, Tcheranova D, Bhattacharya S, Leffler C, Parfenova H. Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-?-induced apoptosis. Am J Physiol Cell Physiol. 2011;300:C256-65 pubmed publisher
    ..The ability of CO to inhibit TNF-?-induced ERK1/2 and p38 MAPK activities in an Akt-dependent manner appears to be the key element in ROS-dependent survival of endothelial cells during TNF-?-mediated brain inflammatory disease...
  6. Xie L, Liu M, Fang L, Su X, Cai K, Wang D, et al. Molecular cloning and functional characterization of porcine stimulator of interferon genes (STING). Dev Comp Immunol. 2010;34:847-54 pubmed publisher
    ..Altogether, these results indicate that STING is an important regulator of porcine innate immune signaling. The results will help better understand the biological role(s) of STING in innate immunity during evolution. ..
  7. Kim J, Song G, Wu G, Gao H, Johnson G, Bazer F. Arginine, leucine, and glutamine stimulate proliferation of porcine trophectoderm cells through the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway. Biol Reprod. 2013;88:113 pubmed publisher
    During the peri-implantation and early placentation periods in pigs, conceptuses (embryo and its extra-embryonic membranes) undergo dramatic morphological changes and differentiation that require the exchange of nutrients (histotroph) and ..
  8. Sun Z, Li Y, Ransburgh R, Snijder E, Fang Y. Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15. J Virol. 2012;86:3839-50 pubmed publisher
    ..Taken together, our data demonstrate that ISG15 and ISGylation play an important role in the response to PRRSV infection and that nsp2 is a key factor in counteracting the antiviral function of ISG15...
  9. Liu J, Bai J, Zhang L, Jiang Z, Wang X, Li Y, et al. Hsp70 positively regulates porcine circovirus type 2 replication in vitro. Virology. 2013;447:52-62 pubmed publisher
    ..These data suggested that Hsp70 positively regulated PCV2 replication, which being helpful for understanding the molecular mechanism of PCV2 infection...

More Information

Publications91

  1. Liu X, Chen H, Tong Q, Li X, Zhu M, Wu Z, et al. Molecular characterization of caveolin-1 in pigs infected with Haemophilus parasuis. J Immunol. 2011;186:3031-46 pubmed publisher
    ..In this study, we provide the molecular characterization of Cav1 in pigs following stimulation with LPS/polyinosinic-polycytidylic acid as well as during infection with Haemophilus ..
  2. Chen H, Lunney J, Cheng L, Li X, Cao J, Zhu M, et al. Porcine S100A8 and S100A9: molecular characterizations and crucial functions in response to Haemophilus parasuis infection. Dev Comp Immunol. 2011;35:490-500 pubmed publisher
    ..Interestingly, the maximum increase of mRNA levels in blood cultures of Meishan pigs is significantly greater than that in Duroc pigs...
  3. De Baere M, Van Gorp H, Delputte P, Nauwynck H. Interaction of the European genotype porcine reproductive and respiratory syndrome virus (PRRSV) with sialoadhesin (CD169/Siglec-1) inhibits alveolar macrophage phagocytosis. Vet Res. 2012;43:47 pubmed publisher
    ..The virus is associated with respiratory problems in pigs of all ages and is commonly isolated on farms with porcine respiratory disease complex (PRDC)...
  4. Wang J, Liu Y, Dong W, Huo Y, Huang X, Wu S, et al. Dynamic changes in TAP1 expression levels in newborn to weaning piglets, and its association with Escherichia coli F18 resistance. Genet Mol Res. 2014;13:3686-92 pubmed publisher
    ..The high expression level of TAP1 indicated that the gene might play an important role in Escherichia coli F18 resistance. ..
  5. Subramaniam S, Kwon B, Beura L, Kuszynski C, Pattnaik A, Osorio F. Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-?B and Sp1. Virology. 2010;406:270-9 pubmed publisher
    ..These findings reveal one of the important mechanisms underlying the innate immune evasion by PRRSV during infection...
  6. Fontanesi L, Speroni C, Buttazzoni L, Scotti E, Dall Olio S, Nanni Costa L, et al. The insulin-like growth factor 2 (IGF2) gene intron3-g.3072G>A polymorphism is not the only Sus scrofa chromosome 2p mutation affecting meat production and carcass traits in pigs: evidence from the effects of a cathepsin D (CTSD) gene polymorphism. J Anim Sci. 2010;88:2235-45 pubmed publisher
    ..We have already shown strong effects of this CTSD mutation on several production traits in Italian Large White pigs, suggesting a possible independent role of this marker in fatness and meat deposition in pigs...
  7. Lee Y, Lee C. Stress-activated protein kinases are involved in porcine reproductive and respiratory syndrome virus infection and modulate virus-induced cytokine production. Virology. 2012;427:80-9 pubmed publisher
    ..Altogether, our data suggest that the p38 and JNK signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection...
  8. Kopera I, Durlej M, Hejmej A, Knapczyk Stwora K, Duda M, Slomczynska M, et al. Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment. Reprod Domest Anim. 2011;46:1050-60 pubmed publisher
    ..analysis and TUNEL staining revealed varying degrees of seminiferous tubules abnormalities in all experimental pigs. Testes of pigs exposed to flutamide in utero exhibited moderate alterations of the spermatogenic process, whereas ..
  9. Hinkel R, Penzkofer D, Zühlke S, Fischer A, Husada W, Xu Q, et al. Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model. Circulation. 2013;128:1066-75 pubmed publisher
    ..b>Pigs (n=5 per group) underwent percutaneous ischemia/reperfusion (60 min/72 h or 7 days, respectively)...
  10. Zhu J, Zi C, Wu Z, Liu L, Zheng X, Su X, et al. Age-dependent expression of the BPI gene in Sutai piglets. Genet Mol Res. 2013;12:2120-6 pubmed publisher
  11. Blitek A, Morawska E, Ziecik A. Regulation of expression and role of leukemia inhibitory factor and interleukin-6 in the uterus of early pregnant pigs. Theriogenology. 2012;78:951-64 pubmed publisher
    ..medium on LIF and IL-6 synthesis in the endometrium; (3) the profiles of IL6R and LIFR mRNA expression in pig conceptuses collected on Days 10 to 18 of pregnancy; and (4) the effect of LIF and IL-6 on the attachment and ..
  12. Blitek A, Morawska E, Kiewisz J, Ziecik A. Effect of conceptus secretions on HOXA10 and PTGS2 gene expression, and PGE2 release in co-cultured luminal epithelial and stromal cells of the porcine endometrium at the time of early implantation. Theriogenology. 2011;76:954-66 pubmed publisher
    ..the endometrium of adult porcine uteri, however there is little information concerning the role of this gene in the pig. Objectives of the present study were to examine: 1) the expression of HOXA10 in the endometrium of cyclic and ..
  13. Aslan O, Hamill R, Davey G, McBryan J, Mullen A, Gispert M, et al. Variation in the IGF2 gene promoter region is associated with intramuscular fat content in porcine skeletal muscle. Mol Biol Rep. 2012;39:4101-10 pubmed publisher
    ..in the insulin-like growth factor 2 gene (IGF2) has been associated with a desirable reduction in BF depth in pigs. Given that the lipid metabolism of intramuscular adipocytes differs from that of subcutaneous fat adipocytes, this ..
  14. Das S, Ravi V, Desai A. Japanese encephalitis virus interacts with vimentin to facilitate its entry into porcine kidney cell line. Virus Res. 2011;160:404-8 pubmed publisher
    ..These observations indicate that vimentin serves as a putative receptor for JEV in porcine kidney cells. ..
  15. Gonzalez Añover P, Encinas T, Torres Rovira L, Sanz E, Pallares P, Ros J, et al. Patterns of corpora lutea growth and progesterone secretion in sows with thrifty genotype and leptin resistance due to leptin receptor gene polymorphisms (Iberian pig). Reprod Domest Anim. 2011;46:1011-6 pubmed publisher
    ..by corpora lutea dynamics and progesterone secretion, in 10 sows with obesity/leptin resistance genotype (Iberian pig) and 10 females of lean commercial crosses (Large White × Landrace)...
  16. Ren J, Duan Y, Qiao R, Yao F, Zhang Z, Yang B, et al. A missense mutation in PPARD causes a major QTL effect on ear size in pigs. PLoS Genet. 2011;7:e1002043 pubmed publisher
    ..Historically, the large-ear feature has been selected for the ancient sacrificial culture in Erhualian pigs. By using a selective sweep analysis, we then refined the critical region to a 630-kb interval containing 9 ..
  17. Schroyen M, Stinckens A, Verhelst R, Geens M, Cox E, Niewold T, et al. Susceptibility of piglets to enterotoxigenic Escherichia coli is not related to the expression of MUC13 and MUC20. Anim Genet. 2012;43:324-7 pubmed publisher
    ..Economically, the swine industry is by far the most affected by infections with ETEC because of mortality, morbidity and decreased growth ..
  18. Luo Y, Bolund L, Sørensen C. Pig gene knockout by rAAV-mediated homologous recombination: comparison of BRCA1 gene knockout efficiency in Yucatan and Göttingen fibroblasts with slightly different target sequences. Transgenic Res. 2012;21:671-6 pubmed publisher
    ..clones have been used as nuclear donor cells for somatic cell nuclear transfer to generate a Göttingen BRCA1 KO pig model as previously done with the Yucatan breed...
  19. Zou H, Li R, Jia Y, Yang X, Ni Y, Cong R, et al. Breed-dependent transcriptional regulation of 5'-untranslated GR (NR3C1) exon 1 mRNA variants in the liver of newborn piglets. PLoS ONE. 2012;7:e40432 pubmed publisher
    ..Previous studies demonstrate striking breed differences in plasma cortisol levels in pigs. However, investigation into the breed-dependent GR transcriptional regulation is hampered by lacking porcine GR ..
  20. Kato S, Siqin -, Minagawa I, Aoshima T, Sagata D, Konishi H, et al. Evidence for expression of relaxin hormone-receptor system in the boar testis. J Endocrinol. 2010;207:135-49 pubmed publisher
    ..Thus, we provide evidence for expression of RLN-RXFP1 ligand-receptor system in the boar testis, suggesting that the testis act as a source and possible target tissue of RLN. ..
  21. Nishimura Y, Kano K, Naito K. Porcine CPEB1 is involved in Cyclin B translation and meiotic resumption in porcine oocytes. Anim Sci J. 2010;81:444-52 pubmed publisher
    ..In addition, the phosphorylation sites of pCPEB1 were identified and are suggested to be phosphorylated by porcine Aurora A. ..
  22. Shinkai H, Okumura N, Suzuki R, Muneta Y, Uenishi H. Toll-like receptor 4 polymorphism impairing lipopolysaccharide signaling in Sus scrofa, and its restricted distribution among Japanese wild boar populations. DNA Cell Biol. 2012;31:575-81 pubmed publisher
    ..We previously found seven amino acid polymorphisms in Sus scrofa TLR4...
  23. Lei B, Gao S, Luo L, Xia X, Jiang S, Deng C, et al. A SNP in the miR-27a gene is associated with litter size in pigs. Mol Biol Rep. 2011;38:3725-9 pubmed publisher
    ..gene was selected as a candidate gene for litter size due to its biological function, its location near a mummified pigs QTL, and its differentially expressed profile in Large White and Chinese Erhualian PMSG-hCG stimulated preovulatory ..
  24. Esteve A, Ojeda A, Huang L, Folch J, Perez Enciso M. Nucleotide variability of the porcine SERPINA6 gene and the origin of a putative causal mutation associated with meat quality. Anim Genet. 2011;42:235-41 pubmed publisher
    ..No support for positive selection was detected, as no reduction in levels of diversity surrounding the mutation was found in lean breeds with respect to wild boar.
  25. Beura L, Dinh P, Osorio F, Pattnaik A. Cellular poly(c) binding proteins 1 and 2 interact with porcine reproductive and respiratory syndrome virus nonstructural protein 1? and support viral replication. J Virol. 2011;85:12939-49 pubmed publisher
    Porcine reproductive and respiratory syndrome virus (PRRSV) infection of swine results in substantial economic losses to the swine industry worldwide...
  26. Wang L, Zhang G, Lin F, Jiang B, Dong F, Liu H. Expression of the insulin-like growth factor system in skeletal muscle during embryonic and postnatal development in the first filial generation pigs from Erhualian and Yorkshire reciprocal crosses. Gen Comp Endocrinol. 2011;173:56-62 pubmed publisher
    ..70 (D70), 120 (D120), and 180 (D180) days of age in the longissimus dorsi (LD) and the semitendinosus (ST) of pigs from a Yorkshire boar×Erhualian sow (YE) cross as well as a Erhualian boar×Yorkshire sow (EY) cross...
  27. Dong X, Bai Y, Xin Y, Xu Q, Chen G, Fang M. Investigation on the transcription factors of porcine 3?-hydroxysteroid dehydrogenase and 17?-hydroxysteroid dehydrogenase genes. Gene. 2012;499:186-90 pubmed publisher
    ..Our study gives new insights to the transcriptional regulation of 3?HSD1 and 17?HSD7 and further hints to their involvement in steroid metabolism. ..
  28. Reyer H, Ponsuksili S, Wimmers K, Murani E. Transcript variants of the porcine glucocorticoid receptor gene (NR3C1). Gen Comp Endocrinol. 2013;189:127-33 pubmed publisher
    ..of alternative processing of NR3C1 in mammalian species and to facilitate future studies of its regulation in the pig we explored here structural diversity, and tissue-specific distribution of transcript variants of the porcine NR3C1,..
  29. Smolinska N, Kaminski T, Siawrys G, Przala J. Expression of leptin and its receptor genes in the ovarian follicles of cycling and early pregnant pigs. Animal. 2013;7:109-17 pubmed publisher
    ..The differences in OB-Rb gene expression in porcine GC and theca cells also suggest that their sensitivity to leptin varies in the ovaries of pregnant and cyclic pigs.
  30. Schlegel W, Halbauer D, Raimann A, Albrecht C, Scharmer D, Sagmeister S, et al. IGF expression patterns and regulation in growth plate chondrocytes. Mol Cell Endocrinol. 2010;327:65-71 pubmed publisher
    ..The abundant expression of IGF-II in porcine growth plate tissue, both on the mRNA and on the protein level, suggests that IGF-II also has a role in growth regulation at the early postnatal stage. ..
  31. Morawska E, Kaczmarek M, Blitek A. Regulation of prostacyclin synthase expression and prostacyclin content in the pig endometrium. Theriogenology. 2012;78:2071-86 pubmed publisher
    ..and protein expression, as well as 6-keto PGF(1?) (a PGI(2) metabolite) concentration, were investigated in the pig uterus...
  32. Yang X, Murani E, Ponsuksili S, Wimmers K. Association of TLR4 polymorphism with cytokine expression level and pulmonary lesion score in pigs. Mol Biol Rep. 2012;39:7003-9 pubmed publisher
    ..of single nucleotide polymorphisms (SNPs) of TLR4 with cytokine expression level and pulmonary lesion score in swine. The SNP c...
  33. Xu S, Linher Melville K, Yang B, Wu D, Li J. Micro-RNA378 (miR-378) regulates ovarian estradiol production by targeting aromatase. Endocrinology. 2011;152:3941-51 pubmed publisher
  34. De Baere M, Van Gorp H, Nauwynck H, Delputte P. Antibody binding to porcine sialoadhesin reduces phagocytic capacity without affecting other macrophage effector functions. Cell Immunol. 2011;271:462-73 pubmed publisher
    ..Thus, antibody binding to pSn can downregulate phagocytosis, which could have implications on homeostasis, infectious and immune diseases, and immunotherapy. ..
  35. Torrado M, Iglesias R, Centeno A, Lopez E, Mikhailov A. Targeted gene-silencing reveals the functional significance of myocardin signaling in the failing heart. PLoS ONE. 2011;6:e26392 pubmed publisher
    ..These data provide the first evidence that a moderate inhibition (e.g., normalization) of the activated MYOCD signaling in the diseased heart may be promising from a therapeutic point of view. ..
  36. Zhao S, Zhang J, Hou X, Zan L, Wang N, Tang Z, et al. OLFML3 expression is decreased during prenatal muscle development and regulated by microRNA-155 in pigs. Int J Biol Sci. 2012;8:459-69 pubmed publisher
    ..In this study, we cloned the porcine OLFML3 gene and detected its tissues distribution in adult Tongcheng pigs and dynamical expression in developmental skeletal muscle (12 prenatal and 10 postnatal stages) from Landrace (lean-..
  37. Bartz M, Szydlowski M, Kociucka B, Salamon S, Jelen H, Switonski M. Transcript abundance of the pig stearoyl-CoA desaturase gene has no effect on fatty acid composition in muscle and fat tissues, but its polymorphism within the putative microRNA target site is associated with daily body weight gain and feed conversio. J Anim Sci. 2013;91:10-9 pubmed publisher
    ..When both breeds were analyzed together, these associations were again highly significant (daily BW gain P<0.003; feed conversion ratio P<0.0001). We conclude that c.*928G>C is a promising marker for both porcine traits. ..
  38. Wessels J, Edwards A, Khalaj K, Kridli R, Bidarimath M, Tayade C. The microRNAome of pregnancy: deciphering miRNA networks at the maternal-fetal interface. PLoS ONE. 2013;8:e72264 pubmed publisher
    ..Using our established model of implantation failure and spontaneous fetal loss in pigs (Sus scrofa), 236 miRNAs were profiled and compared between 1) non-pregnant and pregnant endometrium, 2) maternal and fetal ..
  39. Huang J, Guo X, Fan N, Song J, Zhao B, Ouyang Z, et al. RAG1/2 knockout pigs with severe combined immunodeficiency. J Immunol. 2014;193:1496-503 pubmed publisher
    b>Pigs share many physiological, biochemical, and anatomical similarities with humans and have emerged as valuable large animal models for biomedical research...
  40. Wang L, Xiong Y, Zuo B, Lei M, Ren Z, Xu D. Molecular and functional characterization of glycogen synthase in the porcine satellite cells under insulin treatment. Mol Cell Biochem. 2012;360:169-80 pubmed publisher
    ..biceps femoris (pHBF) and M. semipinalis capitis (pHSC) at 45 min postmortem. These results provide useful information for further investigation on the function of glycogen synthase in porcine skeletal muscle. ..
  41. O Leary S, Armstrong D, Robertson S. Transforming growth factor-? (TGF?) in porcine seminal plasma. Reprod Fertil Dev. 2011;23:748-58 pubmed publisher
    ..It is concluded that TGF? is abundant in boar seminal plasma, leading to the speculation that, in pigs, TGF? may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by ..
  42. Ji H, Ren J, Yan X, Huang X, Zhang B, Zhang Z, et al. The porcine MUC20 gene: molecular characterization and its association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac. Mol Biol Rep. 2011;38:1593-601 pubmed publisher
    Enterotoxigenic Eschoerchia coli (ETEC) F4 is a major cause of diarrhea in neonatal and young pigs. The locus encoding intestinal receptor for ETEC F4ab/ac has been mapped to pig chromosome (SSC) 13q41...
  43. Braunschweig M, Owczarek Lipska M, Stahlberger Saitbekova N. Relationship of porcine IGF2 imprinting status to DNA methylation at the H19 DMD and the IGF2 DMRs 1 and 2. BMC Genet. 2011;12:47 pubmed publisher
    ..at the three porcine CTCF binding sites in the H19 DMD between liver, muscle and kidney tissues of adult pigs. A DNA methylation analysis using methyl-sensitive restriction endonuclease SacII and 'hot-stop' PCR gave ..
  44. Liu L, Wang J, Zhao Q, Zi C, Wu Z, Su X, et al. Genetic variation in exon 10 of the BPI gene is associated with Escherichia coli F18 susceptibility in Sutai piglets. Gene. 2013;523:70-5 pubmed publisher
    ..The AA genotype for the HpaII site in exon 10 of the porcine BPI gene was demonstrated to be an anti-ETEC F18 marker and could be used for selective breeding to enhance ETEC F18 resistance. ..
  45. Paslawska U, Gajek J, Kiczak L, Noszczyk Nowak A, Skrzypczak P, Bania J, et al. Development of porcine model of chronic tachycardia-induced cardiomyopathy. Int J Cardiol. 2011;153:36-41 pubmed publisher
    ..Homogenous siblings of White Large breed swine (n=6) underwent continuous right ventricular (RV) pacing at 170 bpm; 2 subjects served as controls...
  46. Tsuchiya S, Simmer J, Hu J, Richardson A, Yamakoshi F, Yamakoshi Y. Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp). J Bone Miner Res. 2011;26:220-8 pubmed publisher
    ..We conclude that during odontogenesis, astacins in the predentin matrix cleave Dspp before the DDPN sequence at the N-terminus of Dpp to release Dpp from the parent Dspp protein. ..
  47. Soler L, Molenaar A, Merola N, Eckersall P, Gutierrez A, Ceron J, et al. Why working with porcine circulating serum amyloid A is a pig of a job. J Theor Biol. 2013;317:119-25 pubmed publisher
    ..For years, we were not able to isolate systemic pig SAA using the latter methods, and found that the bulk of pig SAA did not reside in the HDL-rich serum fractions but ..
  48. Chen L, Dong X, Zhao M, Shen H, Wang J, Pei J, et al. Classical swine fever virus failed to activate nuclear factor-kappa b signaling pathway both in vitro and in vivo. Virol J. 2012;9:293 pubmed publisher
    Classical swine fever virus (CSFV) is the cause of CSF which is a severe disease of pigs, leading to heavy economic losses in many regions of the world...
  49. Lu L, Wang Y, Sun W, Liu Z, Zhang Q, Pu L, et al. Two-dimensional fluorescence in-gel electrophoresis of coronary restenosis tissues in minipigs: increased adipocyte fatty acid binding protein induces reactive oxygen species-mediated growth and migration in smooth muscle cells. Arterioscler Thromb Vasc Biol. 2013;33:572-80 pubmed publisher
    ..Increased AFABP expression and secretory AFABP of human arterial smooth muscle cells promote growth and migration via reactive oxygen species-mediated activation. ..
  50. Torrado M, Iglesias R, Centeno A, Lopez E, Mikhailov A. Exon-skipping brain natriuretic peptide variant is overexpressed in failing myocardium and attenuates brain natriuretic peptide production in vitro. Exp Biol Med (Maywood). 2010;235:941-51 pubmed publisher
    ..The pig DeltaE2-NPPB mRNA is effectively translated into stable protein in cell-based assays but, in contrast to normally ..
  51. Fang Y, Shi C, Manduchi E, Civelek M, Davies P. MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc Natl Acad Sci U S A. 2010;107:13450-5 pubmed publisher
    ..of regulatory microRNAs to this disequilibrium were investigated by artery site-specific profiling in normal adult swine. Expression of endothelial microRNA10a (miR-10a) was lower in the athero-susceptible regions of the inner aortic ..
  52. Ren J, Yan X, Ai H, Zhang Z, Huang X, Ouyang J, et al. Susceptibility towards enterotoxigenic Escherichia coli F4ac diarrhea is governed by the MUC13 gene in pigs. PLoS ONE. 2012;7:e44573 pubmed publisher
    Enterotoxigenic Escherichia coli (ETEC) F4ac is a major determinant of diarrhea and mortality in neonatal and young pigs. Susceptibility to ETEC F4ac is governed by the intestinal receptor specific for the bacterium and is inherited as a ..
  53. Belouzard S, MADU I, Whittaker G. Elastase-mediated activation of the severe acute respiratory syndrome coronavirus spike protein at discrete sites within the S2 domain. J Biol Chem. 2010;285:22758-63 pubmed publisher
    ..We propose a novel mechanism whereby SARS-CoV fusion protein function can be controlled by spatial regulation of the proteolytic priming site, with important implications for viral pathogenesis. ..
  54. Zhou X, Guo H, Chen K, Cheng H, Zhou R. Identification, chromosomal mapping and conserved synteny of porcine Argonaute family of genes. Genetica. 2010;138:805-12 pubmed publisher
    ..Here we report identification of six Argonaute genes in pig, four members of the Ago subfamily (Ago1, Ago2, Ago3 and Ago4) and two members of the Piwi subfamily (Piwil1 and ..
  55. Kanai R, Ogawa H, Vilsen B, Cornelius F, Toyoshima C. Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state. Nature. 2013;502:201-6 pubmed publisher
    ..Here we describe 2.8?Å-resolution crystal structures of this ATPase from pig kidney with bound Na(+), ADP and aluminium fluoride, a stable phosphate analogue, with and without oligomycin that ..
  56. Blomberg L, Schreier L, Guthrie H, Sample G, Vallet J, Caperna T, et al. The effect of intrauterine growth retardation on the expression of developmental factors in porcine placenta subsequent to the initiation of placentation. Placenta. 2010;31:549-52 pubmed publisher
    Intrauterine growth retardation (IUGR) hinders fetal growth and postnatal development in swine; however the etiology of IUGR is essentially unknown...
  57. Sriperumbudur R, Zorrilla L, Gadsby J. Transforming growth factor-beta (TGFbeta) and its signaling components in peri-ovulatory pig follicles. Anim Reprod Sci. 2010;120:84-94 pubmed publisher
    ..Pre-pubertal pigs were injected with PG-600 followed by hCG, and ovaries were collected surgically at 0, 1, 12, 24 and 48h post-hCG...
  58. Peng J, Tian Z, Liu H, An T, Zhou Y, Wang Y, et al. Cloning and identification of porcine programmed death 1. Vet Immunol Immunopathol. 2010;136:157-62 pubmed publisher
    ..These data suggest that porcine PD-1 negatively regulates the porcine immune response in a similar manner to that of its counterpart in the human and mouse immune system. ..
  59. Gesslein B, Håkansson G, Carpio R, Gustafsson L, Perez M, Malmsjo M. Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion. Mol Vis. 2010;16:392-407 pubmed
    ..The development of pharmacological treatment targeting these intracellular transduction pathways may prevent injury to the eye following retinal circulatory failure. ..
  60. Feugang J, Rodriguez Munoz J, Willard S, Bathgate R, Ryan P. Examination of relaxin and its receptors expression in pig gametes and embryos. Reprod Biol Endocrinol. 2011;9:10 pubmed publisher
    ..as plasma serum, ovarian follicular fluid, utero-oviduct secretions, and seminal plasma of many mammals, including pigs. However, the presence and effects of relaxin in porcine gametes and embryos are still not well-known...
  61. Ren J, Mao H, Zhang Z, Xiao S, Ding N, Huang L. A 6-bp deletion in the TYRP1 gene causes the brown colouration phenotype in Chinese indigenous pigs. Heredity (Edinb). 2011;106:862-8 pubmed publisher
    Brown coat colour has been described in Chinese-Tibetan, Kele, and Dahe pigs. Here, we report the identification of a causal mutation underlying the brown colouration...
  62. Granlund A, Jensen Waern M, Essen Gustavsson B. The influence of the PRKAG3 mutation on glycogen, enzyme activities and fibre types in different skeletal muscles of exercise trained pigs. Acta Vet Scand. 2011;53:20 pubmed publisher
    ..Many pigs of Hampshire origin have a naturally occurring dominant mutation in the AMPK ?3 subunit...
  63. Gonzalez Bulnes A, Torres Rovira L, Ovilo C, Astiz S, Gomez Izquierdo E, Gonzalez Añover P, et al. Reproductive, endocrine and metabolic feto-maternal features and placental gene expression in a swine breed with obesity/leptin resistance. Gen Comp Endocrinol. 2012;176:94-101 pubmed publisher
    The current study was conducted in a swine breed (Iberian pig) with a genotype that predisposed the pig to obesity...
  64. Ren Z, Liu W, Zheng R, Zuo B, Xu D, Lei M, et al. A 304 bp insertion/deletion mutation in promoter region induces the increase of porcine IDH3? gene expression. Mol Biol Rep. 2012;39:1419-26 pubmed publisher
    ..05) or BB. These data suggested that the 304 bp insertion mutation in promoter region increased the expression of porcine IDH3? transcripts and this mutation might be a candidate marker for marker assistant selection in swine breeding.
  65. Waheed F, Speight P, Kawai G, Dan Q, Kapus A, Szaszi K. Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase. Am J Physiol Cell Physiol. 2010;298:C1376-87 pubmed publisher
  66. Wang F, Qiu H, Zhang Q, Peng Z, Liu B. Association of two porcine reproductive and respiratory syndrome virus (PRRSV) receptor genes, CD163 and SN with immune traits. Mol Biol Rep. 2012;39:3971-6 pubmed publisher
    ..05). These results provided fundamental evidence for CD163 and SN as two functional candidate genes affecting immunity in pigs.
  67. Lin Z, Li Y, Xu Y, Wang Q, Namgoong S, Cui X, et al. Effects of growth differentiation factor 9 and bone morphogenetic protein 15 on the in vitro maturation of porcine oocytes. Reprod Domest Anim. 2014;49:219-27 pubmed publisher
    ..and their roles in oocyte maturation and cumulus expansion are well known in the mouse and human, but not in the pig. We investigated GDF9 and BMP15 expressions in porcine oocytes during in vitro maturation...
  68. Balcells I, Castelló A, Mercadé A, Noguera J, Fernandez Rodriguez A, Sanchez A, et al. Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population. BMC Genet. 2011;12:93 pubmed publisher
    ..243A>G and DQ124298:g.344A>G) were genotyped in 347 pigs from the Ib × Me population...
  69. Shimazu T, Villena J, Tohno M, Fujie H, Hosoya S, Shimosato T, et al. Immunobiotic Lactobacillus jensenii elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the Toll-like receptor signaling pathway. Infect Immun. 2012;80:276-88 pubmed publisher
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    ..Here, we report that N(pro) of classical swine fever virus (CSFV) interacts also with IRF7, another mediator of type I IFN induction...
  71. Ojeda A, Ramos Onsins S, Marletta D, Huang L, Folch J, Perez Enciso M. Evolutionary study of a potential selection target region in the pig. Heredity (Edinb). 2011;106:330-8 pubmed publisher
    ..of ?500?bp equally spaced in a 2?Mb region in the vicinity of the FAT1 region in a wide-diversity panel of 32 pigs. Asian and European animals, including local Mediterranean and international pig breeds, were sequenced...
  72. Bhindi R, Fahmy R, McMahon A, Khachigian L, Lowe H. Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion. J Pathol. 2012;227:157-64 pubmed publisher
    ..Taken together, these data suggest that strategies targeting Egr-1 via the intracoronary route after IR injury in pigs have potential therapeutic implications in human MI.
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    ..We sought to determine whether myostatin is expressed in the liver, spleen, lung, and kidney of pigs. Real-time PCR and Western blots demonstrated that myostatin, follistatin, decorin, and activin receptor IIB (..
  74. Robic A, Le Mignon G, Feve K, Larzul C, Riquet J. New investigations around CYP11A1 and its possible involvement in an androstenone QTL characterised in Large White pigs. Genet Sel Evol. 2011;43:15 pubmed publisher
    ..is located in a region where a QTL influencing boar fat androstenone levels has been detected in a Large White pig population...
  75. Corominas J, Ramayo Caldas Y, Puig Oliveras A, Perez Montarelo D, Noguera J, Folch J, et al. Polymorphism in the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs. PLoS ONE. 2013;8:e53687 pubmed publisher
    ..the ELOVL6 gene as a positional candidate gene affecting the percentages of palmitic and palmitoleic fatty acids in pigs. The combination of a haplotype-based approach and single-marker analysis allowed us to identify the main, ..
  76. Renner S, Braun Reichhart C, Blutke A, Herbach N, Emrich D, Streckel E, et al. Permanent neonatal diabetes in INS(C94Y) transgenic pigs. Diabetes. 2013;62:1505-11 pubmed publisher
    ..To establish a large animal model of PNDM, we generated INS(C94Y) transgenic pigs. A line expressing high levels of INS(C94Y) mRNA (70-86% of wild-type INS transcripts) exhibited elevated blood ..
  77. Pan Z, Ye L, Zhu J, DU Z, Huang X, Zhu G, et al. [Isolation of new alleles of the swine TLR4 gene and analysis of its genetic variation]. Yi Chuan. 2011;33:163-7 pubmed
    ..b>Wild boar and all 10 Chinese native pig breeds appeared highly conserved in exon 1 of TLR4 gene, with only CC genotype...
  78. Tu P, Shiau J, Ding S, Lin E, Wu M, Wang P. The association of genetic variations in the promoter region of myostatin gene with growth traits in Duroc pigs. Anim Biotechnol. 2012;23:291-8 pubmed publisher
    ..In this study, the genotypes of MSTN g.435G > A and g.447A > G SNPs in Duroc pigs were determined. The 435GG/447AA individually had significantly higher ADG (P < 0...
  79. Delputte P, Van Gorp H, Favoreel H, Hoebeke I, Delrue I, Dewerchin H, et al. Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages. PLoS ONE. 2011;6:e16827 pubmed publisher
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