Genomes and Genes
Alias: domestic sheep, lambs, wild sheep, Ovis aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, ovine
Publications287 found, 100 shown here
- Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive mannerS M Galloway
AgResearch Molecular Biology Unit, and Centre for Gene Research, Department of Biochemistry, University of Otago, Dunedin, New Zealand
Nat Genet 25:279-83. 2000Multiple ovulations are uncommon in humans, cattle and many breeds of sheep. Pituitary gonadotrophins and as yet unidentified ovarian factors precisely regulate follicular development so that, normally, only one follicle is selected to ..
- Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyperprolificacy phenotype in sheepJulie Demars
INRA, UMR444 Laboratoire de Génétique Cellulaire, Castanet Tolosan, France
PLoS Genet 9:e1003482. 2013Some sheep breeds are naturally prolific, and they are very informative for the studies of reproductive genetics and physiology...
- A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAsC Kimura
Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Ibaraki, Japan
Biochem Biophys Res Commun 166:81-9. 1990..remarkably stimulates adenylate cyclase in rat anterior pituitary cell cultures has been recently isolated from ovine hypothalami by A. Arimura and his collaborators (Biochem.Biophys.Res.Commun.164, 567-574(1989))...
- Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38)A Miyata
U S Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, LA 70037
Biochem Biophys Res Commun 170:643-8. 1990A novel neuropeptide with 38 residues (PACAP38) was isolated from ovine hypothalamic tissues using the pituitary adenylate cyclase activation in rat pituitary cell cultures as a parameter of the biological activity (Miyata et al, Biochem...
- Effects of scrotal heating on sperm surface protein PH-20 expression in sheepJean S Fleming
Department of Anatomy and Structural Biology, Otago School of Medical Science, University of Otago, Dunedin, New Zealand
Mol Reprod Dev 68:103-14. 2004Sperm surface protein PH-20 expression was studied during spermatogenesis in pubertal and adult sheep, using molecular and histological methods...
- Identification of Eya3 and TAC1 as long-day signals in the sheep pituitarySandrine M Dupré
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Curr Biol 20:829-35. 2010Seasonally breeding mammals such as sheep use photoperiod, encoded by the nocturnal secretion of the pineal hormone melatonin, as a critical cue to drive hormone rhythms and synchronize reproduction to the most optimal time of year...
- Compartmentalization of prion isoforms within the reproductive tract of the ramHeath Ecroyd
Gamètes Males et Fertilité, UMR 6175 INRA CNRS Universite de Tours Haras Nationaux, Station de Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France
Biol Reprod 71:993-1001. 2004..In sperm, this C-terminal truncated form was found to be associated with membrane lipid rafts present in the mature sperm, suggesting a role for it in the terminal stages of sperm maturation...
- Origin and evolution of the TKDP gene familyAnindita Chakrabarty
Department of Veterinary Pathobiology, University of Missouri Columbia, Columbia, MO 65211, USA
Gene 373:35-43. 2006..We isolated, mapped and fully sequenced the ovine (ov) TKDP-1 gene...
- The effect of feeding system in the expression of genes related with fat metabolism in semitendinous muscle in sheepE Dervishi
Unidad de Tecnologia en Produccion Animal, CITA, Zaragoza, Spain
Meat Sci 89:91-7. 2011..Forty-four single born male lambs of the Rasa Aragonesa breed, allocated to four different dietary treatments, were used: grazing alfalfa, grazing ..
- Transcriptional profiling of Ovis aries identifies Ovar-DQA1 allele frequency differences between nematode-resistant and susceptible selection linesOrla M Keane
AgResearch Molecular Biology Unit, Department of Biochemistry, University of Otago, Dunedin, New Zealand
Physiol Genomics 30:253-61. 2007..genes whose expression correlates with resistance status, transcriptional profiling of resistant and susceptible sheep was undertaken. Transcription profiles were taken at three time points during the growth of lambs...
- Up-regulation of intelectin in sheep after infection with Teladorsagia circumcinctaAnne T French
Division of Veterinary Clinical Sciences, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
Int J Parasitol 38:467-75. 2008..was also associated with increased levels of abomasal transcripts encoding sheep mast cell protease-1, ovine galectin-14 and IL4, which collectively suggested a Th2 type response...
- Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheepHeather J Billings
Department of Neurobiology and Anatomy, West Virginia University, Health Sciences Center, Morgantown, West Virginia 26506 9128, USA
Endocrinology 151:3836-46. 2010..Based on these data, and the effects of NK3R mutations in humans, we hypothesize that NKB plays an important stimulatory role in the control of GnRH and LH secretion in nonrodent species...
- Pregnancy-associated bovine and ovine glycoproteins exhibit spatially and temporally distinct expression patterns during pregnancyJ A Green
Department of Animal Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
Biol Reprod 62:1624-31. 2000..They show structural resemblance to pepsin and related aspartic proteinases. A total of 21 bovine (bo) PAG and 9 ovine (ov) PAG cDNA have been identified...
- A single-base change in the tyrosine kinase II domain of ovine FGFR3 causes hereditary chondrodysplasia in sheepJ E Beever
Department of Animal Sciences, University of Illinois, Urbana, IL 61801 4734, USA
Anim Genet 37:66-71. 2006..that is characterized by severe skeletal abnormalities and has resulted in substantial economic losses for sheep producers...
- Callipyge mutation affects gene expression in cis: a potential role for chromatin structureSusan K Murphy
Department of Radiation Oncology, Duke University, Durham, North Carolina 27710, USA
Genome Res 16:340-6. 2006Muscular hypertrophy in callipyge sheep results from a single nucleotide substitution located in the genomic interval between the imprinted Delta, Drosophila, Homolog-like 1 (DLK1) and Maternally Expressed Gene 3 (MEG3)...
- An association between lifespan and variation in insulin-like growth factor I receptor in sheepS O Byun
Faculty of Agriculture and Life Sciences, Lincoln University, Canterbury 7647, New Zealand
J Anim Sci 90:2484-7. 2012..Recently, 3 alleles of ovine IGF1R were identified, but no analysis of the effect of IGF1R variation on sheep longevity has been reported...
- Identification of the major pregnancy-specific antigens of cattle and sheep as inactive members of the aspartic proteinase familyS C Xie
Department of Animal Sciences, University of Missouri, Columbia 65211
Proc Natl Acad Sci U S A 88:10247-51. 1991..The inferred sequences of the ovine and bovine polypeptides show approximately 73% identity to each other...
- A chemokine, interferon (IFN)-gamma-inducible protein 10 kDa, is stimulated by IFN-tau and recruits immune cells in the ovine endometriumKentaro Nagaoka
Laboratory of Animal Breeding, Faculty of Agriculture, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
Biol Reprod 68:1413-21. 2003..These results suggest that endometrial IP-10 regulated by conceptus IFN-tau regulates recruitment and/or distribution of immune cells seen in the early pregnant uterus...
- Structural and functional analysis of the HSP90AA1 gene: distribution of polymorphisms among sheep with different responses to scrapieAne Marcos-Carcavilla
Departamento de Mejora Genética Animal, INIA, Ctra La Coruña km 7 5, Madrid, Spain
Cell Stress Chaperones 13:19-29. 2008..In the present work, the ovine HSP90AA1 gene including the promoter and other regulatory regions has been isolated and characterized...
- A SNP in the HSP90AA1 gene 5' flanking region is associated with the adaptation to differential thermal conditions in the ovine speciesAne Marcos-Carcavilla
Departamento de Mejora Genética Animal, INIA, Madrid, Spain
Cell Stress Chaperones 15:67-81. 2010..polymorphisms in the gene encoding the inducible form of the cytoplasmic Hsp90 (HSP90AA1) were addressed in 24 sheep breeds reared in different climatic regions of Europe, Africa, and Asia...
- Polymorphisms in the HSP90AA1 5' flanking region are associated with scrapie incubation period in sheepAne Marcos-Carcavilla
Dpto de Mejora Genética Animal, INIA, 28040, Madrid, Spain
Cell Stress Chaperones 15:343-9. 2010..HSP90AA1) maps within this region and seems to be associated with the resistance/susceptibility to scrapie in sheep. Here, we have analyzed several polymorphisms which were previously described in the ovine HSP90AA1 5' flanking ..
- Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecX(G), FecX(B)) and GDF9 (FecG(H)) in Belclare and Cambridge sheepMichael P Mullen
Department of Microbiology, National University of Ireland, Galway, Ireland
PLoS ONE 8:e53172. 2013..the likely origin of three mutations with large effects on ovulation rate identified in the Belclare and Cambridge sheep breeds; two in the BMP15 gene (FecX(G) and FecX(B)) and the third (FecG(H)) in GDF9...
- Sleeping Beauty-mediated knockdown of sheep myostatin by RNA interferenceShengwei Hu
College of Animal Science and Technology, Shihezi University, Shihezi 832003, China
Biotechnol Lett 33:1949-53. 2011..of myostatin was achieved by combining RNA interference and the Sleeping Beauty (SB) transposon system in sheep cells...
- The keratin BIIIB gene family: isolation of cDNA clones and structure of a gene and a related pseudogeneM J Frenkel
CSIRO Division of Biotechnology, Parkville, Victoria, Australia
Genomics 4:182-91. 1989..Although Southern blot analysis indicates that the BIIIB genes comprise a multigene family in the sheep genome, they are poorly represented in genomic DNA libraries...
- Differential expression of genes encoding a cysteine-rich keratin family in the hair cuticleB J Jenkins
Hanson Centre for Cancer Research, Division of Human Immunology, University of Adelaide, Australia
J Invest Dermatol 103:310-7. 1994..Two clones of the sheep KAP5 gene family were isolated: the KAP5...
- Co-expression of vascular endothelial growth factor and neuropilin-1 in ovine feto-placental artery endothelial cellsStephen C M Tsoi
Department of Obstetrics and Gynecology, University of Wisconsin Madison, 7E Meriter Hospital, 202 S Park St, Madison, WI 53715, USA
Mol Cell Endocrinol 196:95-106. 2002..To evaluate the role of VEGF and NP-1 in regulating fetoplacental angiogenesis and endothelial function, an ovine fetal placental artery endothelial (OFPAE) cell line was established...
- Ovine stem cell factor gene is located within a syntenic group on chromosome 3 conserved across mammalian speciesD J Tisdall
AgResearch, Wallaceville, Animal Research Centre, Upper Hutt, New Zealand
Mamm Genome 7:472-3. 1996
- Expression of the ovine stem cell factor gene during folliculogenesis in late fetal and adult ovariesD J Tisdall
AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
J Mol Endocrinol 18:127-35. 1997..5 kb in follicles, corpora lutea and stroma of mid-luteal sheep ovaries...
- Isolation of the ovine agouti coding sequenceY M Parsons
School of Biological Sciences, Macquarie University Sydney, NSW, Australia
Pigment Cell Res 12:394-7. 1999
- The crystal structure of the globular domain of sheep prion proteinL F Haire
Structural Biology Group, Division of Protein Structure, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
J Mol Biol 336:1175-83. 2004..crystal structure, at 2 A resolution, of residues 123-230 of the C-terminal globular domain of the ARQ allele of sheep prion protein (PrP)...
- Ovine progressive pneumonia provirus levels associate with breed and Ovar-DRB1Lynn M Herrmann-Hoesing
US Department of Agriculture, Animal Disease Research Unit, Agricultural Research Service, Pullman, WA 99164 6630, USA
Immunogenetics 60:749-58. 2008..of OPPV as measured by provirus levels in the peripheral blood associates with certain breeds and MHC class II Ovis aries (Ovar)-DRB1 expressed alleles...
- Genetic testing for TMEM154 mutations associated with lentivirus susceptibility in sheepMichael P Heaton
U S Meat Animal Research Center USMARC, Clay Center, Nebraska, USA
PLoS ONE 8:e55490. 2013..Known as ovine progressive pneumonia virus (OPPV) in the U.S...
- Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewesP Mulsant
Institut National de la Recherche Agronomique, Laboratoire de Genetique Cellulaire, BP, 27, 31326 Castanet Tolosan, France
Proc Natl Acad Sci U S A 98:5104-9. 2001Ewes from the Booroola strain of Australian Mérino sheep are characterized by high ovulation rate and litter size...
- Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility in Thoka sheepLinda Nicol
MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Reproduction 138:921-33. 2009..Previously, several mutations have been identified in sheep which increase the naturally low ovulation rate; although in some cases homozygous ewes are infertile...
- KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and seasonJeremy T Smith
Department of Physiology, P O Box 13F, Monash University, Victoria 3800, Australia
Endocrinology 148:1150-7. 2007..Furthermore, a seasonal alteration in KiSS-1 expression in the ARC of OVX ewes strongly suggests that kisspeptin is fundamentally involved in the control of seasonal changes in reproductive function...
- Aquaporin-0 membrane junctions reveal the structure of a closed water poreTamir Gonen
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 429:193-7. 2004..The water pathway in AQP0 also contains an additional pore constriction, not seen in other known aquaporin structures, which may be responsible for pore gating...
- Lipid-protein interactions in double-layered two-dimensional AQP0 crystalsTamir Gonen
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 438:633-8. 2005..We were therefore able to build an atomic model for the lipid bilayer surrounding the AQP0 tetramers, and we describe lipid-protein interactions...
- Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variantsFrederic Eghiaian
Laboratoire d Enzymologie et de Biochimie Structurales, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
Proc Natl Acad Sci U S A 101:10254-9. 2004..We report here the 2.5-A-resolution crystal structures of three scrapie-susceptibility ovine PrP variants complexed with an antibody that binds to PrPC and to PrPSc; they identify two important features of ..
- Cry1 circadian phase in vitro: wrapped up with an E-boxJ M Fustin
Aberdeen University, School of Biological Sciences, Aberdeen, UK
J Biol Rhythms 24:16-24. 2009....
- Common promoter deletion is associated with 3.9-fold differential transcription of ovine CCR5 and reduced proviral level of ovine progressive pneumonia virusS N White
Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, WA 99164, USA
Anim Genet 40:583-9. 2009..Both ovine progressive pneumonia virus (OPPV), also known as maedi-visna, and HIV are macrophage-tropic lentiviruses, have ..
- Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertensionJing Tian
Pulmonary Vascular Disease Program, Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA
Physiol Genomics 40:48-60. 2009..of PPARgamma and the upregulation of HMMR, Flk-1, FGF2, and Cav-1 proteins in the peripheral lung tissues of an ovine model of PH...
- Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip geneW Goldmann
Institute for Animal Health, AFRC and MRC Neuropathogenesis Unit, Edinburgh, U K
J Gen Virol 72:2411-7. 1991The incubation period of scrapie in sheep is controlled by the Sip gene which has two alleles (sA and pA). Following experimental challenge with SSBP/1 scrapie, a short incubation period is conferred by the partially dominant sA allele...
- cDNA sequence of two sheep mast cell tryptases and the differential expression of tryptase and sheep mast cell proteinase-1 in lung, dermis and gastrointestinal tractA D Pemberton
Wellcome Trust Centre for Research and Comparative Respiratory Medicine, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, UK
Clin Exp Allergy 30:818-32. 2000..Trials in sheep showed that administration of a specific tryptase inhibitor reduced the late-phase response to inhaled allergen.
- The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) geneC J Souza
Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers St, Edinburgh, EH3 9ET, UK
J Endocrinol 169:R1-6. 2001Genetic variations in ovulation rate which occur in different breeds of sheep provide useful models to explore the mechanisms regulating the development of antral follicles...
- Temporal expression of seven clock genes in the suprachiasmatic nucleus and the pars tuberalis of the sheep: evidence for an internal coincidence timerGerald Lincoln
Medical Research Council, Human Reproductive Sciences Unit, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK
Proc Natl Acad Sci U S A 99:13890-5. 2002..SCN) and the pars tuberalis (PT) of the pituitary gland, collected every 4 h throughout 24 h, from female Soay sheep kept under long (16-h light/8-h dark) or short (8-h light/16-h dark) photoperiods...
- A novel mutation in the bone morphogenetic protein 15 gene causing defective protein secretion is associated with both increased ovulation rate and sterility in Lacaune sheepLoys Bodin
Institut National de la Recherche Agronomique, UR631, tation d Amélioration Génétique des Animaux, BP 52627, 31326 Castanet Tolosan, France
Endocrinology 148:393-400. 2007Genetic mutations with major effects on ovulation rate and litter size in sheep were recently identified in three genes belonging to the TGFbeta superfamily pathway: the bone morphogenetic protein 15 (BMP15, also known as GDF9b), growth ..
- A new large animal model of CLN5 neuronal ceroid lipofuscinosis in Borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571+1G>A) leading to excision of exon 3Tony Frugier
Lincoln University, Agriculture and Life Sciences Division, Cell Biology Group, PO Box 84, Lincoln 7647, Canterbury, New Zealand
Neurobiol Dis 29:306-15. 2008..Linkage analysis indicated a CLN5 form in a colony of affected New Zealand Borderdale sheep. Sequencing studies established the disease-causing mutation to be a substitution at a consensus splice site (c...
- A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in Rasa Aragonesa sheepA Martinez-Royo
CITA, Unidad de Tecnologia en Produccion Animal, 50059 Zaragoza, Spain
Anim Genet 39:294-7. 2008..of the transforming growth factor beta superfamily, is specifically expressed in oocytes and is essential for sheep prolificacy...
- Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosisManfred J Oswald
Agriculture and Life Sciences Division, Lincoln University, Lincoln 7647, New Zealand
Neurobiol Dis 32:50-65. 2008The neuronal ceroid lipofuscinoses (NCLs, Batten disease) are fatal inherited neurodegenerative diseases. Sheep affected with the CLN6 form provide a valuable model to investigate underlying disease mechanisms from preclinical stages...
- Effect of scrapie on the stability of housekeeping genesJ Lyahyai
Laboratorio de Genetica Bioquimica LAGENBIO, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain
Anim Biotechnol 21:1-13. 2010..Gene expression analysis of normal and infected sheep may provide clues to clarify the molecular mechanisms involved in the neuropathology of these diseases...
- Characterization of ovine Toll-like receptor 9 protein coding region, comparative analysis, detection of mutations and maedi visna infectionIvan Mikula
Laboratory of Biomedical Microbiology and Immunology, University of Veterinary Medicine and Pharmacy, Komenskeho 73, 041 81 Kosice, Slovakia
Dev Comp Immunol 35:182-92. 2011..In this study, we characterized the protein coding region of ovine TLR9 gene...
- Evidence for RGS4 modulation of melatonin and thyrotrophin signalling pathways in the pars tuberalisS M Dupre
Faculty of Life Sciences, University of Manchester, Manchester, UK
J Neuroendocrinol 23:725-32. 2011..5-fold after melatonin treatment. Correspondingly, RGS4 expression is acutely sensitive to changing day length. In sheep acclimated to short days (SP, 8 h light/day), RGS4 expression increases sharply following dark onset, peaking in ..
- Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectodermK Imakawa
Department of Animal Sciences, University of Missouri, Columbia 65211
Nature 330:377-9. 1987..The active substance implicated in signalling maternal recognition of pregnancy in the sheep is an embryonic secretory protein, known as ovine trophoblast protein-1 (oTP-1) (refs 2-4), which is targeted in a ..
- Selective cloning of cDNA for secretory proteins of early embryos. Identification of a transiently expressed kunitz domain protein from preimplantation sheep trophoblastK K Kramer
Department of Animal Sciences, University of Missouri, Columbia
J Biol Chem 269:7255-61. 1994The preimplantation ovine conceptus transiently secretes several proteins, including a type I interferon (IFN-tau), that are likely involved in establishment of pregnancy...
- PrP (prion) gene expression in sheep may be modulated by alternative polyadenylation of its messenger RNAW Goldmann
Neuropathogenesis Unit, BBSRC Institute for Animal Health, Edinburgh, UK
J Gen Virol 80:2275-83. 1999..expression in the hosts of these diseases, we have analysed some characteristics of PrP gene RNA transcripts in sheep and cattle tissues and made comparisons with PrP RNA transcripts in human and mouse tissues...
- Polymorphisms of the prion protein gene in sheep of Inner Mongolia, ChinaYiqin Wang
National Animal Transmissible Spongiform Encephalopathies Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
Virus Genes 37:128-30. 2008..of the prion protein gene (Prnp), especially the amino acid residue alterations at codons 136, 154, and 174, in sheep have been found to be associated with susceptibility to scrapie disease...
- Polymorphism in two genes for B2 high sulfur proteins of woolG R Rogers
Animal and Veterinary Sciences Group, Lincoln University, Canterbury, New Zealand
Anim Genet 25:407-15. 1994....
- Distribution of aromatase mRNA in the ram hypothalamus: an in situ hybridization studyC E Roselli
Department of Physiology and Pharmacology, School of Medicine, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
J Neuroendocrinol 12:656-64. 2000..circuit supports a role for aromatization in the mechanism of testosterone action on reproductive function in male sheep. The distribution of aromatase mRNA in the ovine hypothalamus was similar to that described for other vertebrate ..
- Cloning and expression of ovine placental lactogenP Colosi
Department of Developmental Biology, Genentech, Inc, South San Francisco, California 94080
Mol Endocrinol 3:1462-9. 1989b>Ovine placental lactogen (oPL) is active in a wide range of GH and PRL assays, a property that it shares with human GH (hGH). In addition, oPL is one of a small number of hormones that bind the human GH receptor with high affinity...
- Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapieD Westaway
Department of Neurology, University of California, San Francisco 94143
Genes Dev 8:959-69. 1994..To address this conundrum, we determined the structure of the sheep prion protein (PrP) gene, which contains three exons and extends over 20 kb of DNA. In the United States 86...
- Control of interferon-tau gene expression by Ets-2T Ezashi
Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
Proc Natl Acad Sci U S A 95:7882-7. 1998..factors of the Ets family, Ets-2 and GABPalpha, were identified, consistent with the observation that active ovine IFN-tau genes contain a single 10-bp Ets motif (core: GGAA) in the proximal segment, whereas three known inactive ..
- The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting statusC Charlier
Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, Liege, Belgium
Nat Genet 27:367-9. 2001..CLPG) phenotype (from kappa(alpha)lambda(iota), "beautiful," and pi(iota)gamma(epsilon), "buttocks") described in sheep is an inherited muscular hypertrophy that is subject to an unusual parent-of-origin effect referred to as polar ..
- Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8C Charlier
Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 4000 Liege, Belgium
Genome Res 11:850-62. 2001Two ovine BAC clones and a connecting long-range PCR product, jointly spanning approximately 250 kb and representing most of the MULGE5-OY3 marker interval known to contain the clpg locus, were completely sequenced...
- Identification of a new leucine haplotype (ALQ) at codon 154 in the ovine prion protein gene in Spanish sheepL Alvarez
Departamento de Producción Animal I, Universidad de Leon, 24071 Leon, Spain
J Anim Sci 84:259-65. 2006..In this paper, we describe the method used with 2 Spanish dairy sheep breeds (Churra and Castellana) to ascertain the initial status of protection against scrapie as a first step ..
- Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteinsStefán R Jónsson
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
Nucleic Acids Res 34:5683-94. 2006..Here, we report an APOBEC3F-like, double deaminase domain protein from three artiodactyls: cattle, pigs and sheep. Like their human counterparts, APOBEC3F and APOBEC3G, the artiodactyl APOBEC3F proteins are DNA cytosine ..
- Gene expression profiles of novel caprine placental prolactin-related proteins similar to bovine placental prolactin-related proteinsKoichi Ushizawa
Reproductive Biology Research Unit, Division of Animal Sciences, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, Ibaraki 305 8602, Japan
BMC Dev Biol 7:16. 2007..Caprine PRPs are compared with known bovine PRPs. We examined their evolution and role in the ruminant placenta...
- Analysis of the callipyge phenotype through skeletal muscle development; association of Dlk1 with muscle precursor cellsJason D White
School of Veterinary Science, The University of Melbourne, Parkville, VIC 3010, Australia
Differentiation 76:283-98. 2008The callipyge mutation in sheep in the form of the paternal heterozygote results in skeletal muscle hypertrophy, which is most pronounced in the hindquarters...
- Expression and characterization of novel ovine orthologs of bovine placental prolactin-related proteinsKoichi Ushizawa
Reproductive Biology Research Unit, Division of Animal Sciences, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, Ibaraki 305 8602, Japan
BMC Mol Biol 8:95. 2007..We investigated placental PRP in sheep in order to gain a comprehensive understanding of the function and evolution of these molecules...
- Two alleles of a neural protein gene linked to scrapie in sheepW Goldmann
Center for Molecular Biology, University of Heidelberg, Federal Republic of Germany
Proc Natl Acad Sci U S A 87:2476-80. 1990b>Sheep are the natural hosts of the pathogens that cause scrapie, an infectious degenerative disease of the central nervous system...
- PrP genotype contributes to determining survival times of sheep with natural scrapieA Bossers
Department of Bacteriology, DLO Institute for Animal Science and Health, Lelystad, The Netherlands
J Gen Virol 77:2669-73. 1996Several allelic variants of the sheep PrP gene are associated with scrapie susceptibility. However, it is not known whether, and to what extent, the PrP genotype contributes to determining survival times of scrapie sheep...
- Complete genomic sequence and analysis of the prion protein gene region from three mammalian speciesI Y Lee
Department of Molecular Biotechnology, University of Washington, Seattle, Washington 98195 7730 USA
Genome Res 8:1022-37. 1998..organization of regions surrounding the PrP exons, we sequenced 10(5) bp of DNA from clones containing human, sheep, and mouse PrP genes isolated in cosmids or lambda phage...
- The callipyge locus: evidence for the trans interaction of reciprocally imprinted genesMichel Georges
Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 20 Bd de Colonster, 4000 Liege, Belgium
Trends Genet 19:248-52. 2003The callipyge phenotype in sheep is an inherited muscular hypertrophy that affects only heterozygous individuals who receive the CLPG mutation from their father...
- Complete nucleotide sequence of ovine alpha-lactalbumin mRNAP Gaye
Laboratoire de Physiologie de la Lactation, INRA, Jouy en Josas, France
Biochimie 69:601-8. 1987The nucleotide sequence of ovine alpha-lactalbumin mRNA has been determined by chemical sequencing of two cDNA recombinant plasmids and a primer extension product...
- Dietary cysteine regulates the levels of mRNAs encoding a family of cysteine-rich proteins of woolA Fratini
Department of Biochemistry, University of Adelaide, Australia
J Invest Dermatol 102:178-85. 1994The abomasal or intravenous infusion of sulphur-containing amino acids such as cysteine or methionine into sheep on low-quality diets increases the sulphur content of the wool by increasing the synthesis of proteins containing a cysteine ..
- Sequence, expression, and evolutionary conservation of a gene encoding a glycine/tyrosine-rich keratin-associated protein of hairA Fratini
Department of Biochemistry, University of Adelaide, South Australia
J Biol Chem 268:4511-8. 1993..keratin-associated proteins encoded by the KAP6 gene family, a partial wool follicle cDNA clone encoding a sheep KAP6 protein was sequenced and the corresponding gene isolated from a sheep cosmid library. The KAP6...
- Identification of five allelic variants of the sheep PrP gene and their association with natural scrapieP B Belt
Department of Molecular Biology, DLO Institute for Animal Science and Health ID DLO, Lelystad, The Netherlands
J Gen Virol 76:509-17. 1995Scrapie is a fatal neurodegenerative disease of sheep that belongs to the group of prion diseases found in humans and animals. The host encoded prion protein (PrP) plays a central role in the disease process...
- Isolation, characterization and evolution of ovine major histocompatibility complex class II DRA and DQA genesS A Fabb
Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
Anim Genet 24:249-55. 1993Four full-length ovine major histocompatibility complex (MHC) class II A cDNA clones coding for new alleles of DRA, DQA1 and DQA2 genes were isolated from two ovine lambda gt10 cDNA libraries...
- oPer1 is an early response gene under photoperiodic regulation in the ovine pars tuberalisP J Morgan
Molecular Neuroendocrinology Unit, Rowett Research Institute, Aberdeen, Scotland, UK
J Neuroendocrinol 10:319-23. 1998..In sheep, PT tissue photoperiodic background influences the magnitude or timing of expression of oPer1 2 h after lights-on...
- The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries) and comparison with the other major ovine haplotypeS Hiendleder
Department of Animal Breeding and Genetics, Justus Liebig University, Ludwigstr 21b, D 35390 Giessen, Germany
J Mol Evol 47:441-8. 1998The complete mitochondrial DNA (mtDNA) molecule of the domestic sheep, Ovis aries, was sequenced, together with part of the mtDNA of a specimen representing the other major O. aries haplotype group...
- IFN-tau: a novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialitiesJ L Martal
INRA, Station de Physiologie Animale, Unité Endocrinologie de l Embryon, Jouy en Josas, France
Biochimie 80:755-77. 1998..It is believed to suppress pulsatile release of endometrial PGF-2alpha by preventing oxytocin and estrogen receptor expression. Additionally, it directly regulates prostaglandin metabolism and possibly the PGE:PGF-2alpha ratio...
- Ovine osteopontin: II. Osteopontin and alpha(v)beta(3) integrin expression in the uterus and conceptus during the periimplantation periodG A Johnson
Department of Animal Science, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843 2471, USA
Biol Reprod 61:892-9. 1999....
- Progesterone modulation of osteopontin gene expression in the ovine uterusG A Johnson
Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Center, College Station, Texas 77843 2471, USA
Biol Reprod 62:1315-21. 2000..317 (ZK; progesterone receptor [PR] antagonist, Days 11-24) and CX proteins; 3) P and recombinant ovine IFNtau (roIFNtau, Days 11-24); or 4) P and ZK and roIFNtau. All ewes were hysterectomized on Day 25...
- The productive conformation of arachidonic acid bound to prostaglandin synthaseM G Malkowski
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
Science 289:1933-7. 2000....
- Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cellsT Wilson
AgResearch Molecular Biology Unit, Department of Biochemistry, University of Otago, Dunedin, New Zealand
Biol Reprod 64:1225-35. 2001The Booroola fecundity gene (FecB) increases ovulation rate and litter size in sheep and is inherited as a single autosomal locus. The effect of FecB is additive for ovulation rate (increasing by about 1...
- The PrP-like protein Doppel gene in sheep and cattle: cDNA sequence and expressionM A Tranulis
Department of Biochemistry, Physiology and Nutrition, Norwegian School of Veterinary Science, N 0033 Oslo, Norway
Mamm Genome 12:376-9. 2001..2 and 3.6 kb on Northern blots. Sequence alignments showed a very high degree of identity between the sheep and cattle Dpl cDNAs, except for a 0...
- Muc-1, integrin, and osteopontin expression during the implantation cascade in sheepG A Johnson
Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
Biol Reprod 65:820-8. 2001..The potential involvement of OPN in the implantation adhesion cascade in sheep was investigated by examining temporal, spatial, and potential functional relationships between OPN, Muc-1, and ..
- Differential expression of the GTL2 gene within the callipyge region of ovine chromosome 18C A Bidwell
Department of Animal Sciences, Purdue University, West Lafayette, IN 49707 1026, USA
Anim Genet 32:248-56. 2001..The CN-NN probes hybridized to two ovine and seven bovine BACs...
- PrP genotype in Sarda breed sheep and its relevance to scrapie. Brief reportG Vaccari
Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, Rome, Italy
Arch Virol 146:2029-37. 2001Several PrP gene polymorphisms modulate sheep scrapie susceptibility. Recently, an increase of scrapie outbreaks has been reported in Italy. A vaccine containing sheep brain homogenate was used in most of the outbreaks...
- Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancyGreg A Johnson
Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
Biol Reprod 69:92-8. 2003..In sheep and humans, OPN is proposed to be a secretory product of uterine glandular epithelium (GE) that binds to uterine ..
- Mapping and characterization of the dominant black colour locus in sheepDag Inge Våge
Department of Animal Science, Agricultural University of Norway, As, Norway
Pigment Cell Res 16:693-7. 2003Dominant black pigment synthesis in sheep is caused by alterations of the melanocortin-1 receptor (MC1-R) coding sequence...
- Prion protein gene polymorphisms in healthy and scrapie-affected sheep in GreeceCharalambos Billinis
Laboratory of Microbiology and Infectious Diseases, Faculty of Veterinary Medicine, Aristotle University, GR 54124 Thessaloniki, Greece
J Gen Virol 85:547-54. 2004A total of 216 local crossbred sheep from 16 scrapie-affected Greek flocks and 210 purebred sheep of the milk breeds Chios and Karagouniko from healthy flocks were analysed for scrapie-linked polymorphisms in the prion protein (PrP) gene...
- Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotypeErica Davis
Department of Genetics, Faculty of Veterinary Medicine, University of Liege, B 43 Sart Tilman, Boulevard du Colonster 20, 4000 Liege, Belgium
Curr Biol 14:1858-62. 2004The callipyge (CLPG) phenotype is an inherited skeletal muscle hypertrophy described in sheep. It is characterized by an unusual mode of inheritance ("polar overdominance") in which only heterozygous individuals having received the CLPG ..
- Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ERalpha and ERbeta levelsMichael J Byers
Perinatal Research Laboratories, University of Wisconsin Madison Medical School, Department of Obstetrics and Gynecology, Atrium B Meriter Hospital Park, Madison, WI 53715, USA
J Physiol 565:85-99. 2005..Compared to luteal phase sheep, both ERalpha and ERbeta levels in UAendo were elevated in follicular phase sheep...
- Identification of a mutation in the ovine uroporphyrinogen decarboxylase (UROD) gene associated with a type of porphyriaR Nezamzadeh
Institute of Veterinary Medicine, University of Gottingen, Gottingen, Germany
Anim Genet 36:297-302. 2005..Although disorders of haeme biosynthesis have been described in cattle, pigs, sheep and cats, PCT has only been reported in pigs...
- Selection of ovine housekeeping genes for normalisation by real-time RT-PCR; analysis of PrP gene expression and genetic susceptibility to scrapieDavid Garcia-Crespo
Department of Animal Health, Instituto Vasco de Investigacion y Desarrollo Agrario NEIKER, Berreaga, 1 48160 Derio, Bizkaia, Spain
BMC Vet Res 1:3. 2005..To test the hypothetical linkage between PrP gene expression and genetic susceptibility, PrP mRNA levels were measured by real-time RT-PCR in six ovine tissues of animals with different genotypes.
- Identification and phylogenetic analysis of 15 MHC class II DRB1 beta1 expressed alleles in a ewe-lamb flockLynn M Herrmann
Animal Disease Research Unit, USDA ARS, 3003 ADBF, Washington State University, Pullman, 99164 6630, USA
Immunogenetics 57:855-63. 2005Ovar-DRB1 is part of the major histocompatibility complex (MHC) class II of sheep and functions by presenting extracellular-derived peptides to the immune system...
- Dynamic expression of the prion-like protein Doppel in ovine testicular tissueArild Espenes
Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
Int J Androl 29:400-8. 2006..We have investigated the expression pattern and some biochemical properties of Dpl in sheep testicular tissue and spermatozoa. Neither the Dpl protein nor its mRNA was detected in pre-pubertal sheep testis...
- Stanniocalcin (STC) in the endometrial glands of the ovine uterus: regulation by progesterone and placental hormonesGwonhwa Song
Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
Biol Reprod 74:913-22. 2006..These studies determined the effects of pregnancy and related hormones on STC expression in the ovine uterus. In Days 10-16 cyclic and pregnant ewes, STC1 mRNA was not detected in the uterus...
- Prion protein gene (PRNP) polymorphisms in Xinjiang local sheep breeds in ChinaZ Lan
Life Sciences and Technology College, Ocean University of China, Qingdao, P R China
Arch Virol 151:2095-101. 2006..those occurring at codons 136, 154, and 171 have a significant influence on scrapie pathogenesis in many sheep breeds...
- Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and developmentFeng Guan
College of Life Sciences, China Jiliang University, Hangzhou 310018, Zhejiang Province, China
Anim Reprod Sci 99:44-52. 2007..2 (+/-0.68) (P < 0.01). At 90 days after birth, the body weights of BB/B+ lambs were higher than that of ++ lambs (18.6 +/- 3.70 kg, 18.0 +/- 3.71 kg versus 15.6 +/- 2.22 kg, P < 0.05)...
- Development of a linkage map and mapping of phenotypic polymorphisms in a free-living population of Soay sheep (Ovis aries)Dario Beraldi
Institute of Evolutionary Biology, University of Edinburgh, UK
Genetics 173:1521-37. 2006..Horn type maps to chromosome 10, a location similar to that previously identified in domestic sheep. These findings represent an advance in the dissection of the genetic diversity in the wild and provide the ..
- Endocrine Disruptors and Fetal DevelopmentVasantha Padmanabhan; Fiscal Year: 2010..Our preliminary studies using sheep as a model revealed that prenatal exposure to the plasticizer bisphenol A (BPA), an environmentally pervasive ..
- Mark D Zabel; Fiscal Year: 2016DESCRIPTION (provided by applicant): Transmissible spongiform encephalopathies (TSEs) include scrapie in sheep;bovine spongiform encephalopathy (BSE) in cattle;chronic wasting disease (CWD) in deer and elk;and Kuru and Creutzfeldt-Jakob ..
- Characterization of prion protein conformational changesVALERIE D DAGGETT; Fiscal Year: 2010..TSEs, or prion diseases, include Creutzfeldt-Jakob disease, fatal familial insomnia and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer and elk...
- Role of Fetal Steroids in Formation and Activation of Bovine Ovarian FolliclesJoanne E Fortune; Fiscal Year: 2010..In cattle, sheep, and other large mammals, including humans, primordial follicles form over a number of weeks during fetal life, in ..
- Assessing the Transmissibility of CWD to HumansQingzhong Kong; Fiscal Year: 2010..to humans directly (Aim 1)? Can CWD be transmitted to humans after passage through secondary hosts (cattle or sheep) (Aim 2)? Has CWD transmission to humans already occurred (Aim 3)? The ultimate goals are to define the risks of ..
- Shinji Makino; Fiscal Year: 2014..endemic disease of sub-Saharan Africa that can emerge in explosive mosquito-borne epidemics, decimating herds of sheep and cattle and resulting in enormous economic losses;humans are infected concurrently, and their infection results ..
- Se Jin Lee; Fiscal Year: 2014..Subsequent genetic studies in cattle, sheep, dogs, and humans have all shown that the function of myostatin as a negative regulator of muscle mass has been ..
- Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigenAna M Espino; Fiscal Year: 2013..Fasciola hepatica causes liver fluke disease or fascioliasis, thereby affecting the health of humans, as well as sheep, cattle and goats, among others mammalians. Fascioliasis causes losses in agriculture estimated at >US3...
- HEATHER MICHELLE FRITZ; Fiscal Year: 2015..g. swine, cattle, sheep) containing bradyzoite tissue cysts, or through congenital transmission...
- Preventing Human Prion Diseases - Inactivation of PrionsStanley B Prusiner; Fiscal Year: 2010..Initially, we plan to study three strains of prions passaged in mice: RML and 301V, which originated from sheep with scrapie and cattle with BSE, respectively, plus a novel synthetic strain MoSP1, which is the most stable ..
- Structure and assembly of the fungal prion HET-sWilliam N Wan; Fiscal Year: 2013..TSEs include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer and elk, and several ..
- Characterization of de novo generation of infectious prionsJoaquin Castilla; Fiscal Year: 2009..e. Bovine spongiform encephalopathy (BSE) in US cattle and Nor98 (atypical scrapie) in New Zealand sheep, provide evidence that this infrequent spontaneous phenomenon may occur naturally...
- NCRR RESEARCH TRAINING FOR TUFTS VETERINARY STUDENTSROBERT STAFFORD BRIDGES; Fiscal Year: 2011..Using animal models that include pigs, horses, sheep, goats, cats, dogs, rats and mice, program faculty will provide intensive laboratory training in the research ..
- Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity InfectionAnthony E Kincaid; Fiscal Year: 2013..spread of prion disease between animals, such as chronic wasting disease in deer and elk, and scrapie in sheep and goats...
- NCRR RESEARCH TRAINING FOR TUFTS VETERINARY STUDENTSROBERT STAFFORD BRIDGES; Fiscal Year: 2013..Using animal models that include pigs, horses, sheep, goats, cats, dogs, rats and mice, program faculty will provide intensive laboratory training in the research ..
- Structural Characterization of Prion Isoforms in Multiple TSE DiseasesMICHELE ANN MCGUIRL; Fiscal Year: 2012..and variant CJD, Gerstmann- Straussler-Scheinker disease, Fatal Familial Insomnia, and kuru (humans), scrapie (sheep), chronic wasting disease (elk, deer), and mad cow disease (cattle)...
- LINDA HICKAM; Fiscal Year: 2014..764 egg dealers, 8 processors, as well as 1,445 total permitted and licensed dairy farms, including goat and sheep with the Missouri State Milk Board...
- Impact of Microparticles on Oral TSE InfectionsJoel A Pedersen; Fiscal Year: 2012..PUBLIC HEALTH RELEVANCE: Prion diseases are transmissible neurologic disorders that can affect animals (sheep scrapie, cervid chronic wasting disease, bovine spongiform encephalopathy) and humans (Creutzfeldt-Jakob disease ..
- Key molecular mechanisms of extraneural pathogenesis and transmission of TSEsMark D Zabel; Fiscal Year: 2012..These include chronic wating disease (CWD) of deer and elk, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jacob disease and kuru in humans...
- REGULATION OF OTP-1 AND HCG GENES IN OVINE TROPHOBLASTGeorge Seidel; Fiscal Year: 1993..Proteins secreted by the concept us that communicate its presence to the mother have been identified: in sheep, ovine trophoblast protein-1 (oTP-1); cattle, (bTP- 1); and humans, human chorionic gonadotropin (hCG)...
- GREGORY CHARLES GRAY; Fiscal Year: 2016..economy in 1992, Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle...
- Artiodactyl Gene Modification with Tal Effector NucleasesSCOTT CHRISTOPHER FAHRENKRUG; Fiscal Year: 2012..The studies proposed here will establish a new paradigm for the genetic modification of artiodactyls (pigs, sheep, and cattle) for use as large animal models of human disease and the production of biomedical materials...
- SYNTHESES AND CELLULAR STUDIES OF NEW PHOTOSENSITIZERS FOR MEDICAL APPLICATIONSKevin M Smith; Fiscal Year: 2013..from blood, bone marrow purging, and for inhibition of transmissible spongiform encephalopathies [bovine (BSE), sheep (scrapie) and human forms (Creutzfeld-Jacob disease)]...
- Therapeutic Approaches for Prion DiseaseThomas M Wisniewski; Fiscal Year: 2013..to : 1): Development of the optimal oral vaccination method in wild-type mice and transgenic mice expressing elk, sheep or human PrP;2) Characterization of the immune response in successfully vaccinated animals and the development of ..
- Surachai Supattapone; Fiscal Year: 2016..To test this hypothesis, we will simulate the rendering process in the laboratory and study whether sheep scrapie and deer CWD can be converted into promiscuous strains capable of infecting humans or cows...
- Specific amyloid-beta oligomer aptamersKaren H Ashe; Fiscal Year: 2010..DNA aptamers capable of detecting the scrapie isoform of the prion protein in the blood of scrapie-infected sheep, at levels far below the detection threshold of immunoblotting methods...
- Lawrence D Longo; Fiscal Year: 2014..Based on >21 years of research by our group, studies will be conducted in sheep acclimatized to high altitude (3801 m/12,470 ft). We shall test a number of hypotheses...
- Qizhen Shi; Fiscal Year: 2016..sufficient platelet-FVIII expression and rescue the hemorrhagic phenotype in hemophilic mice and hemophilic sheep with inhibitors...
- Sean W Limesand; Fiscal Year: 2016..chronic catecholamine stimulation (coupled with hypoxia and hypoglycemia) modulates insulin secretion in fetal sheep with placental insufficiency, a model system that shares many similarities to human IUGR fetuses with placental ..
- A novel model for studying fetal skeletal muscle developmentMin Du; Fiscal Year: 2009..Pregnant sheep carrying these fetuses will be allowed to lamb which will then be euthanized for muscle collection...
- Intrauterine chronic hypoxia and ryanodine receptors in fetal pulmonary arteriesSean M Wilson; Fiscal Year: 2013..Gestation at high altitude causes a variety of pulmonary vascular malformations in fetal sheep including suppressed endothelium dependent relaxation, altered myocyte growth, and reactivity that place them at ..
- Stephanie R Wesolowski; Fiscal Year: 2014..which are normally absent during fetal life, are strikingly up-regulated in the late gestation IUGR fetal sheep. Our data also indicate that insulin fails to suppress glucose production in the IUGR fetus, yet robustly ..
- Peter W Nathanielsz; Fiscal Year: 2016..Whilst primary causes are diverse, poor F development is generally secondary to F NR. Rodent and sheep studies provide insight but parallel nonhuman primate (NHP) data are minimal...
- Effects of maternal cortisol on fetal and neonatal growth and metabolismMaureen Keller-Wood; Fiscal Year: 2013..In these studies we will use pregnant sheep in late gestation to test several hypotheses relating to effects of maternal cortisol on fetal growth and on ..
- Bisphenol-A and Reproductive DysfunctionVasantha Padmanabhan; Fiscal Year: 2013..Our preliminary studies using sheep as a model revealed that prenatal exposure to the plasticizer bisphenol A (BPA), an environmentally relevant EDC, ..
- Ramen Chmait; Fiscal Year: 2014..next translational step of the project requires the successful implantation of a functional device into a fetal sheep to demonstrate proof of concept in a relevant pre-clinical animal model...
- DongBao Chen; Fiscal Year: 2016..Five specific aims will be studied by using the well-defined sheep uterine artery endothelial cell culture model and human umbilical cord vein endothelial cells...
- Stephen P Ford; Fiscal Year: 2016..No comprehensive studies on neonatal leptin exist in precocial species, humans or important farm animals. Our sheep model of diet-induced maternal obesity (MO) increases adult OFF appetite and adiposity...
- STUDIES OF UTEROPLACENTAL CIRCULATIONCHARLES RICHARD ROSENFELD; Fiscal Year: 2013..g., diabetes. To address these questions, we will study chronically instrumented nonpregnant, pregnant and fetal sheep, which provide physiologic data and observations that can be explained by parallel studies of biochemical, ..
- Cellular and molecular mechanisms of preterm white matter injuryArt Riddle; Fiscal Year: 2013..We will determine if recurrent ischemia imparts increased susceptibility or resistance on glia and axons in our ovine model of white matter injury...
- Endogenous Retroviruses and Placental MorphogenesisThomas E Spencer; Fiscal Year: 2011..betaretoviruses during the peri-implantation period of conceptus development and placental morphogenesis in sheep. Sheep harbor endogenous betaretroviruses (termed endogenous Jaagsiekte Sheep Retroviruses or enJSRVs) that are ..
- Role of nitrite and hemoglobin in vascular NO homeostasis in the fetus and adultArlin B Blood; Fiscal Year: 2013..The first will use chronically instrumented near-term fetal sheep to determine the effects of circulating nitrite on the fetal cardiovasculature and oxygen consumption, and whether ..
- Late Preterm Birth, Ureaplasma Species and Childhood Lung DiseaseSuhas Kallapur; Fiscal Year: 2012..parvum chorioamnionitis in fetal sheep. The clinical study will select cohorts of late preterm infants based on cultures for Ureaplasma spp, and ..
- Thyroid regulation of cardiomyocyte maturationKENT L R THORNBURG; Fiscal Year: 2013DESCRIPTION (provided by applicant): In fetal sheep, cardiomyocytes gradually cease dividing and become binucleated (terminal differentiation) at ~100 days of a 145 day gestational period...
- IN UTERO STEM CELL TRANSPLANTATIONEsmail Zanjani; Fiscal Year: 2011..will enable achievement of therapeutic levels of HSC engraftment following IUSCT and cure a clinically relevant sheep model of a lysosomal storage disease...
- William J Pearce; Fiscal Year: 2015..will be conducted in middle cerebral arteries from term fetal lambs, newborn lambs, and non-pregnant adult sheep to define the effects of postnatal age on these regulatory mechanisms...
- Physiologic Cardiovascular & Uterine eNOS Responses:Role of Endogenous EstrogenRonald R Magness; Fiscal Year: 2010..Specific Aim 1: Development of an Ovine Animal Model of Endogenous Estrogen Blockade Using Letrozole (CGS 20267);IC1182,78, L-NAME and DHEA effects: ..
- Mechanisms of Fetal Inflammatory Response Syndrome Induced by ChorioamnionitisSuhas Kallapur; Fiscal Year: 2013..The experiments will utilize the preterm fetal sheep model of chorioamniontis induced by intraamniotic endotoxin developed by our group that closely mimics human ..
- Fetal Endocrine-Cardiovascular RelationsJames C Rose; Fiscal Year: 2011..We will study a widely used animal model, the sheep, because it is similar to humans in terms of the timing of nephrogenesis relative to stage of gestation and these ..
- Fetal Endocrine Disruption by TriclosanCharles E Wood; Fiscal Year: 2012..This proposal will use the fetal sheep model of in utero fetal development to examine the consequences of inhibiting placental SULT1E1...
- Vasantha Padmanabhan; Fiscal Year: 2015..This proposal aims to capitalize on this recently validated sheep model to test a novel, unifying hypothesis for the developmental origins of infertility disorders namely "..
- Lung Injury with Resuscitation of the PretermNoah H Hillman; Fiscal Year: 2013..The research will focus on the mechanisms of lung Injury caused by the resuscitation of preterms using preterm sheep models. This program will provide new evidence for resuscitation guidelines for preterm infants...
- Leptin and hypothalamo-pituitary-adrenal function in the long-term hypoxic fetusCharles A Ducsay; Fiscal Year: 2013..We have shown that the HPA axis of fetal sheep undergoes significant adaptation in response to LTH...
- Developing a preventive cure for cerebral palsySidhartha Tan; Fiscal Year: 2010..a second, non-rodent animal model of brain injury related to another paradigm, umbilical cord occlusion, in fetal sheep. This model allows detailed fetal surveillance, to evaluate potential side-effects and, critically, allows us to ..
- Alterations of complex behaviors in sheep by pre-natal bisphenol A exposureElizabeth M Peckham; Fiscal Year: 2013..Studies in rodents have implicated prenatal BPA exposure in a variety of health problems. We propose to use sheep as a model to examine the effects of prenatal BPA on complex behaviors...
- Fetal and Neonatal Pituitary-Adrenal FunctionJames C Rose; Fiscal Year: 2010..ACTH precursors and thereby arrests the development of the fetal adrenal to secrete the primary glucocorticoid in sheep, cortisol...
- Charles E Roselli; Fiscal Year: 2016..The ovine SDN (oSDN) develops prior to birth and is enlarged by testosterone exposure during a prenatal critical period that ..
- Pancreatic beta-cell endothelial cell function and signaling in intrauterine growPAUL JOSEPH ROZANCE; Fiscal Year: 2013..p-cell to endothelial cellsignaling as the cause of decresaed p-cell mass and insulinsecretion in a fetal sheep model of placental insufficincy and IUGR...
- OVINE MODEL SYSTEM FOR ALCOHOL RELATED BIRTH DEFECTSShannon E Washburn; Fiscal Year: 2012..In this proposal, we will exploit the unique advantages of the well established sheep model to investigate basic mechanisms by which alcohol causes brain injury and to begin exploring protective ..
- The Primate Corpus Luteum: Functional Regression and Cardiovascular ImpactsRandy L Bogan; Fiscal Year: 2012..Dr. Bogan's graduate research utilized sheep as an experimental model to study mechanisms controlling the synthesis of progesterone (P4) by the corpus luteum (..
- Structural and molecular basis of drug-induced IKACh reductionSAMI FOUAD NOUJAIM; Fiscal Year: 2012..My preliminary data indicate that chloroquine: 1- terminates cholinergic AF in the isolated sheep heart;2- impedes ion movement through the channel's vestibule by interacting with specific amino acid ..
- SAMI FOUAD NOUJAIM; Fiscal Year: 2014..My preliminary data indicate that chloroquine: 1- terminates cholinergic AF in the isolated sheep heart;2- impedes ion movement through the channel's vestibule by interacting with specific amino acid ..
- Novel Therapy for PreeclampsiaJames W Larrick; Fiscal Year: 2012..Digibind (GlaxoSmithKline) is a commercially available anti-digoxin sheep polyclonal antibody approved for the treatment of digoxin overdose. Digibind cross-reacts with MBG and other CTS...
- TRANSMISSIBLE AND GENETIC NEURODENGENERATIVE DISEASESSTANLEY PRUSINER; Fiscal Year: 1999..Molecular genetic studies in sheep, mice and humans have shown that susceptibility to prion diseases--natural scrapie of sheep, experimental scrapie ..
- Targeted genome modification of guinea pig and sheep using engineered zinc fingerHilda Holcombe; Fiscal Year: 2011..rodent and one non-rodent, to demonstrate proof of concept and to generate genetically modified guinea pigs and sheep that are valuable models for human diseases...
- Anti-fibrotic Coatings for Rapidly Exchangeable Bioprosthetic Heart ValveIvan Vesely; Fiscal Year: 2010..second, VXI investigated the ability of anti-adhesion coatings to abate fibrotic overgrowth in the hyper-fibrotic sheep model...
- KDR--A NOVEL FUNCTIONAL HEMATOPOIETIC STEM CELL MARKERCesare Peschle; Fiscal Year: 2004..The KDR+ fraction comprises virtually all HSCs, i.e., repopulating HSCs assayed in NOD-SCID mice and fetal sheep xenografts, and putative HSCs assayed in 12-wk extended Dexter type long term culture (ELTC) as ELTC-initiating ..
- THE EFFECTS OF COCAINE ON FETAL OXYGENATIONJames Woods; Fiscal Year: 1993..laboratory suggest that intravenous cocaine produces greater systemic responses in the pregnant than nonpregnant sheep which are accompanied by reduced uterine blood flow and fetal oxygen levels...
- Exchangeable Heart Valve for Tissue Engineering ApplicationsIvan Vesely; Fiscal Year: 2007..Progress in this field has been hampered by the cost of the experimental model - the juvenile sheep that has a tissue-engineered valve implanted in the aortic position...
- LUNG FUNCTION IN PROLONGED HEART FAILUREMarie Francoise Doursout; Fiscal Year: 2004..The first specific aim is to test if lung connective tissue is increased and late phase edema occurs in a sheep model of elevated Pc...
- RENAL FUNCTION AND BLOOD PRESSURE CONTROL IN PREGNANCYEdmond Quillen; Fiscal Year: 2000..These studies will be conducted in vivo using non- pregnant and pregnant sheep, and then supplemented with a number of cellular and molecular approaches to further define mechanisms of action...
- Maternal nutrient restriction and nonhuman primate fetal skeletal muscle developmMin Du; Fiscal Year: 2010..Underlying mechanisms remain undefined. RATIONALE: Sheep and rat studies indicate that FNR affects fetal skeletal muscle (SM) development with long-lasting effects on ..
- MECHANISMS OF HYPOXIC CEREBRAL VASODILATATION IN NEWBORNWilliam Pearce; Fiscal Year: 1992..carotid, basilar, posterior communicating, and rostral choroidal arteries taken from 3-7 day old lambs and adult sheep. Three main hypotheses will be examined...
- Robert L Mauck; Fiscal Year: 2016..Next, scaffolds will be formed into anatomic shapes, and used to repair subtotal meniscectomies in a sheep model...
- Paracorporeal Artificial Lung DevelopmentScott Merz; Fiscal Year: 2001..UTMB) in a pulmonary artery-to-pulmonary artery (PA-PA) configuration, and supported gas exchange in normal sheep (N=8) for up to 7 days...
- Maternal Obesity: A Sheep ModelJorge Figueroa; Fiscal Year: 2009..the following specific aims: Specific Aim 1: To establish an animal model of maternal obesity (overfeeding) in sheep fed a complete balanced diet...
- SYSTEMIC AND LOCAL REGULATION OF MYOMETRIAL ACTIVITYJorge Figueroa; Fiscal Year: 1993..the sympathoadrenal system (SAS), prostaglandins (PG) and oxytocin (OT) in regulating myometrial activity in sheep. I will study these interactive factors in non pregnant ewes and pregnant ewes both before and during labor...
- Antenatal Betamethasone in Late Preterm Gestation LambsSATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010..Late preterm lambs (134 d gestation, term ~ 145 d) delivered by elective cesarean section following two, one or no doses of antenatal ..
- Antenatal betamethasone for persistent pulmonary hypertension of newbornGirija G Konduri; Fiscal Year: 2010..Studies in fetal lambs with prenatal ductal constriction, a model that mimics PPHN, have shown that pulmonary vascular dysfunction is ..
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