cow

Summary

Alias: domestic cow, domestic cattle, cattle, bovine, Bos taurus, Bos primigenius taurus, Bos bovis, Bos Tauurus, Bovidae sp. Adi Nefas

Top Publications

  1. ncbi Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition
    Bernard Grisart
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 4000 Liege, Belgium
    Genome Res 12:222-31. 2002
  2. pmc Double muscling in cattle due to mutations in the myostatin gene
    A C McPherron
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:12457-61. 1997
  3. pmc Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition
    Bernard Grisart
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 20 Boulevard de Colonster, 4000 Liege Sart Tilman, Belgium
    Proc Natl Acad Sci U S A 101:2398-403. 2004
  4. pmc Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2
    Sebastien Fritz
    UNCEIA, Genetics Team, Paris, France
    PLoS ONE 8:e65550. 2013
  5. pmc Identification of a nonsense mutation in CWC15 associated with decreased reproductive efficiency in Jersey cattle
    Tad S Sonstegard
    Bovine Functional Genomics, United States Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA
    PLoS ONE 8:e54872. 2013
  6. pmc Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows
    John B Cole
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, Maryland, USA
    BMC Genomics 12:408. 2011
  7. pmc Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content
    Andreas Winter
    Lehrstuhl für Tierzucht der Technischen Universität München, 85350 Freising Weihenstephan, Germany
    Proc Natl Acad Sci U S A 99:9300-5. 2002
  8. ncbi Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
    M Amano
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 01
    J Biol Chem 271:20246-9. 1996
  9. pmc ZNF280BY and ZNF280AY: autosome derived Y-chromosome gene families in Bovidae
    Yang Yang
    Department of Dairy and Animal Science, The Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 12:13. 2011
  10. ncbi Bovine prion protein gene (PRNP) promoter polymorphisms modulate PRNP expression and may be responsible for differences in bovine spongiform encephalopathy susceptibility
    Petra Sander
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine, Hannover, Germany
    J Biol Chem 280:37408-14. 2005

Detail Information

Publications368 found, 100 shown here

  1. ncbi Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition
    Bernard Grisart
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 4000 Liege, Belgium
    Genome Res 12:222-31. 2002
    ..trait locus (QTL) with a major effect on milk composition--particularly fat content--to the centromeric end of bovine chromosome 14...
  2. pmc Double muscling in cattle due to mutations in the myostatin gene
    A C McPherron
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:12457-61. 1997
    ..myostatin sequences of nine other vertebrate species and the identification of mutations in the coding sequence of bovine myostatin in two breeds of double-muscled cattle, Belgian Blue and Piedmontese, which are known to have an ..
  3. pmc Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition
    Bernard Grisart
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 20 Boulevard de Colonster, 4000 Liege Sart Tilman, Belgium
    Proc Natl Acad Sci U S A 101:2398-403. 2004
    ..used a positional cloning approach to identify a nonconservative lysine to alanine substitution (K232A) in the bovine DGAT1 gene that was proposed to be the causative quantitative trait nucleotide underlying a quantitative trait ..
  4. pmc Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2
    Sebastien Fritz
    UNCEIA, Genetics Team, Paris, France
    PLoS ONE 8:e65550. 2013
    The regular decrease of female fertility over time is a major concern in modern dairy cattle industry...
  5. pmc Identification of a nonsense mutation in CWC15 associated with decreased reproductive efficiency in Jersey cattle
    Tad S Sonstegard
    Bovine Functional Genomics, United States Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA
    PLoS ONE 8:e54872. 2013
    ..This search led to the discovery of a putative recessive lethal in Jersey cattle on Bos taurus autosome 15...
  6. pmc Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows
    John B Cole
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, Maryland, USA
    BMC Genomics 12:408. 2011
    ..Here, we report results of a genome-wide analysis of predicted transmitting ability (PTA) of 31 production, health, reproduction and body conformation traits in contemporary Holstein cows...
  7. pmc Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content
    Andreas Winter
    Lehrstuhl für Tierzucht der Technischen Universität München, 85350 Freising Weihenstephan, Germany
    Proc Natl Acad Sci U S A 99:9300-5. 2002
    ..Our mapping studies placed DGAT1 close to the region of a quantitative trait locus (QTL) on bovine chromosome 14 for variation in fat content of milk...
  8. ncbi Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
    M Amano
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 01
    J Biol Chem 271:20246-9. 1996
    ..The activated Rho-kinase subsequently phosphorylates MLC. This may partly account for the mechanism by which Rho regulates cytokinesis, cell motility, or smooth muscle contraction...
  9. pmc ZNF280BY and ZNF280AY: autosome derived Y-chromosome gene families in Bovidae
    Yang Yang
    Department of Dairy and Animal Science, The Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 12:13. 2011
    ..These transpositions are lineage-dependent. The purpose of this study is to investigate the lineage-specific Y-chromosome genes in bovid...
  10. ncbi Bovine prion protein gene (PRNP) promoter polymorphisms modulate PRNP expression and may be responsible for differences in bovine spongiform encephalopathy susceptibility
    Petra Sander
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine, Hannover, Germany
    J Biol Chem 280:37408-14. 2005
    ..within the bovine PRNP gene have little or no effect on bovine spongiform encephalopathy (BSE) susceptibility in cattle. We have recently found a tentative association between PRNP promoter polymorphisms and BSE susceptibility in ..
  11. ncbi A bovine homologue of the human TSPY gene
    S Jakubiczka
    Institut fur Humangenetik, Medizinische Hochschule Hannover, Germany
    Genomics 17:732-5. 1993
    We have isolated a male-specific bovine genomic homologue of the human TSPY gene (testis-specific protein, Y-encoded). Two specific transcripts can be detected in bovine testicular RNA...
  12. pmc A splice site variant in the bovine RNF11 gene compromises growth and regulation of the inflammatory response
    Arnaud Sartelet
    Unit of Animal Genomics, GIGA R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    PLoS Genet 8:e1002581. 2012
    We report association mapping of a locus on bovine chromosome 3 that underlies a Mendelian form of stunted growth in Belgian Blue Cattle (BBC)...
  13. ncbi Assessment of positional candidate genes myf5 and igf1 for growth on bovine chromosome 5 in commercial lines of Bos taurus
    C Li
    Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    J Anim Sci 82:1-7. 2004
    ..BWT), preweaning average daily gain (PWADG), and average daily gain on feed (ADGF) in commercial lines of Bos taurus. The QTL regions for the growth traits identified using a haplotype association analysis, which included the ..
  14. ncbi Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder
    Wei Yang
    Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Mol Immunol 45:1385-97. 2008
    ..We examined here, if inadequate activation of the bovine TLR2 and TLR4 pathogen receptors by ligands derived from S...
  15. ncbi Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle
    R Kambadur
    AgResearch, Ruakura, Hamilton, New Zealand
    Genome Res 7:910-6. 1997
    ..The autosomal recessive mh locus causing double-muscling condition in these cattle maps to bovine chromosome 2 within the same interval as myostatin, a member of the TGF-beta superfamily of genes...
  16. doi Transition period-related changes in the abundance of the mRNAs of adiponectin and its receptors, of visfatin, and of fatty acid binding receptors in adipose tissue of high-yielding dairy cows
    Anneka Lemor
    Institute for Animal Science, Physiology and Hygiene Unit, University of Bonn, Katzenburgweg 7 9, Bonn, Germany
    Domest Anim Endocrinol 37:37-44. 2009
    ..In addition, visfatin, GPR 41, and GPR 109A may further modulate insulin sensitivity...
  17. doi Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genes
    A Wang
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    J Dairy Sci 92:2696-705. 2009
    ..energy, but also regulate rumen development, insulin and glucagon secretion, and other physiological processes in cattle and sheep. The mechanism underlying the regulatory effects of VFA is unknown...
  18. doi Allelic heterogeneity of Crooked Tail Syndrome: result of balancing selection?
    A Sartelet
    Unit of Animal Genomics, GIGA R and Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    Anim Genet 43:604-7. 2012
    ..1906T>C) in the bovine MRC2 gene causing the Crooked Tail Syndrome in Belgian Blue Cattle. We demonstrate that the ensuing substitution of the highly conserved Cysteine 636 with Arginine causes ..
  19. pmc Identification of splice variants, targeted microRNAs and functional single nucleotide polymorphisms of the BOLA-DQA2 gene in dairy cattle
    Qinlei Hou
    Laboratory of Molecular Genetics and Breeding, Center of Dairy Cattle Research, Shandong Academy of Agricultural Sciences, Jinan, China
    DNA Cell Biol 31:739-44. 2012
    Major histocompatibility complex, class II, DQ alpha 2, also named BOLA-DQA2, belongs to the Bovine Leukocyte Antigen (BOLA) class II genes which are involved in the immune response...
  20. doi Genetic heterogeneity at the bovine KIT gene in cattle breeds carrying different putative alleles at the spotting locus
    L Fontanesi
    DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
    Anim Genet 41:295-303. 2010
    According to classical genetic studies, piebaldism in cattle is largely influenced by the allelic series at the spotting locus (S), which includes the S(H) (Hereford pattern), S(+) (non-spotted) and s (spotted) alleles...
  21. pmc High-efficiency utilization of the bovine integrin alpha(v)beta(3) as a receptor for foot-and-mouth disease virus is dependent on the bovine beta(3) subunit
    S Neff
    Foot and Mouth Disease Research Unit, USDA Agricultural Research Service, Plum Island Animal Disease Center, Greenport, New York 11944, USA
    J Virol 74:7298-306. 2000
    We have previously reported that Foot-and-mouth disease virus (FMDV), which is virulent for cattle and swine, can utilize the integrin alpha(v)beta(3) as a receptor on cultured cells...
  22. pmc Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking
    Yasuko Iwakiri
    Section of Digestive Diseases, Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 103:19777-82. 2006
    ..These data indicate that local NOS action generates organelle-specific protein S-nitrosylation reactions that can regulate intracellular transport processes...
  23. ncbi Nitric oxide activates TRP channels by cysteine S-nitrosylation
    Takashi Yoshida
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    Nat Chem Biol 2:596-607. 2006
    ..These findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families...
  24. ncbi Identification and expression of Toll-like receptors 1-10 in selected bovine and ovine tissues
    Moira Menzies
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Vet Immunol Immunopathol 109:23-30. 2006
    ..b>Bovine sequence exists for 4 of the 10 human TLR Reference Sequences and no ovine TLR sequence has been reported...
  25. ncbi Modulation of the oligomerization state of the bovine F1-ATPase inhibitor protein, IF1, by pH
    E Cabezon
    Medical Research Council Dunn Human Nutrition Unit, Cambridge, United Kingdom
    J Biol Chem 275:25460-4. 2000
    b>Bovine IF(1), a basic protein of 84 amino acids, is involved in the regulation of the catalytic activity of the F(1) domain of ATP synthase. At pH 6.5, but not at basic pH values, it inhibits the ATP hydrolase activity of the enzyme...
  26. ncbi Crystal structure of rhodopsin: A G protein-coupled receptor
    K Palczewski
    Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
    Science 289:739-45. 2000
    ..Identification of a set of residues that mediate interactions between the transmembrane helices and the cytoplasmic surface, where G-protein activation occurs, also suggests a possible structural change upon photoactivation...
  27. doi Copy number variation of testis-specific protein, Y-encoded (TSPY) in 14 different breeds of cattle (Bos taurus)
    C K Hamilton
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Sex Dev 3:205-13. 2009
    ..Previous studies have estimated that TSPY ranges from 50-200 copies in cattle. To examine TSPY localization on the Y chromosome we employed fluorescence in situ hybridization (FISH) and fiber-..
  28. ncbi DGAT1 underlies large genetic variation in milk-fat composition of dairy cows
    A Schennink
    Animal Breeding and Genomics Centre, Wageningen University, 6700 AH Wageningen, The Netherlands
    Anim Genet 38:467-73. 2007
    ..001). We conclude that selective breeding can make a significant contribution to change the fat composition of cow's milk.
  29. ncbi Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding
    G Zhou
    Skirball Institute of Biomolecular Medicine, Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Cell Sci 114:4095-103. 2001
    ..coli, and that the binding of uropathogenic bacteria to uroplakin Ia may play a key role in mediating the urothelial responses to bacterial attachment...
  30. pmc Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease
    Natalia Friedland
    Center for Advanced Biotechnology and Medicine, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 100:2512-7. 2003
    ..NPC2 has an Ig-like fold stabilized by three disulfide bonds. The structure of the bovine protein reveals a loosely packed region penetrating from the surface into the hydrophobic core that forms adjacent ..
  31. pmc Mapping of a milk production quantitative trait locus to a 420-kb region on bovine chromosome 6
    Hanne Gro Olsen
    Department of Animal and Aquacultural Sciences, Agricultural University of Norway, N 1432 Aas, Norway
    Genetics 169:275-83. 2005
    ..By using radiation hybrid mapping as well as BAC clones, the bovine and human comparative maps in the region are resolved, and the QTL is mapped within a distance of 420 kb.
  32. pmc A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation
    Bo Thomsen
    Department of Genetics and Biotechnology, Danish Institute of Agricultural Sciences, DK 8830 Tjele, Denmark
    Genome Res 16:97-105. 2006
    The extensive use of a limited number of elite bulls in cattle breeding can lead to rapid spread of recessively inherited disorders...
  33. pmc Domain structure of a mammalian myosin I beta
    O Reizes
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas 75235
    Proc Natl Acad Sci U S A 91:6349-53. 1994
    We have determined the primary structure of a myosin I (called mammalian myosin I beta, MMI beta) from bovine brain and identified its functional domains. The protein was previously purified from brain and adrenal gland...
  34. doi Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81
    Changlu Liu
    Johnson and Johnson Pharmaceutical Research and Development LLC, San Diego, CA 92121, USA
    J Biol Chem 284:2811-22. 2009
    ..Our results indicate that lactate suppresses lipolysis in adipose tissue through a direct activation of GPR81. GPR81 may thus be an attractive target for the treatment of dyslipidemia and other metabolic disorders...
  35. ncbi Closing the folding chamber of the eukaryotic chaperonin requires the transition state of ATP hydrolysis
    Anne S Meyer
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 113:369-81. 2003
    ..Understanding the distinct mechanisms governing eukaryotic and bacterial chaperonin function may reveal how TRiC has evolved to fold specific eukaryotic proteins...
  36. ncbi Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state
    T Tanaka
    Division of Molecular and Structural Biology, Ontario Cancer Institute, Toronto, Canada
    Nature 376:444-7. 1995
    ..The myristoyl group is sequestered in a deep hydrophobic pocket formed by many aromatic and other hydrophobic residues from five flanking helices...
  37. pmc An unusual splice defect in the mitofusin 2 gene (MFN2) is associated with degenerative axonopathy in Tyrolean Grey cattle
    Cord Drogemuller
    Institute of Genetics, University of Bern, Bern, Switzerland
    PLoS ONE 6:e18931. 2011
    Tyrolean Grey cattle represent a local breed with a population size of ∼5000 registered cows. In 2003, a previously unknown neurological disorder was recognized in Tyrolean Grey cattle...
  38. pmc Hydrogen peroxide is the major oxidant product of xanthine oxidase
    Eric E Kelley
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Free Radic Biol Med 48:493-8. 2010
    ..Furthermore, XO bound to glycosaminoglycans on the apical surface of bovine aortic endothelial cells demonstrated a similar ROS production profile...
  39. pmc Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle
    T Goldammer
    Molecular Biology Research Division, Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    Clin Diagn Lab Immunol 11:174-85. 2004
    ..the impact of this system on the counteraction of infections of the mammary gland (mastitis), we characterized the bovine gene encoding the key PRR Toll-like receptor 9 (TLR9) and mapped its precise position on chromosome BTA22...
  40. pmc Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins
    J Yu
    Ronald O Perelman Department of Dermatology, New York University Medical School, New York 10016
    J Cell Biol 125:171-82. 1994
    ..indicate that the outer leaflet of AUM is composed of crystalline patches of 12-nm protein particles, and that bovine AUMs contain three major proteins: the 27- to 28-kD uroplakin I, the 15-kD uroplakin II and the 47-kD uroplakin ..
  41. ncbi Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein
    K M Flaherty
    Beckman Laboratories for Structural Biology, Department of Cell Biology, Stanford University School of Medicine, California 94305 5400
    Nature 346:623-8. 1990
    The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A...
  42. ncbi Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein
    X R Wu
    Ronald O Perelman Department of Dermatology, New York University School of Medicine, NY 10016
    J Cell Sci 106:31-43. 1993
    ..The fact that of the three major proteins of AUM only UPIII has a significant cytoplasmic domain suggests that this molecule may play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells...
  43. pmc Identification of core amino acids stabilizing rhodopsin
    A J Rader
    Center for Computational Biology and Bioinformatics, Department of Molecular Biology and Biochemistry, School of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 101:7246-51. 2004
    ..The observed high degree of conservation (78.9%) of this disulfide bond across all GPCR classes suggests that it is critical for the stability and function of GPCRs...
  44. ncbi Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransduction
    W A Gorczyca
    Department of Ophthalmology, University of Washington, Seattle 98195
    J Biol Chem 270:22029-36. 1995
    ....
  45. doi Highly effective SNP-based association mapping and management of recessive defects in livestock
    Carole Charlier
    Unit of Animal Genomics, GIGA Research and Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège B34, 1 Avenue de l Hopital, 4000 Liege, Belgium
    Nat Genet 40:449-54. 2008
    ..We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle ..
  46. pmc Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomes
    Anne Sophie Van Laere
    Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liege, Belgium
    Genome Res 18:1884-95. 2008
    Here, we report the sequence characterization of the bovine pseudoautosomal boundary (PAB) and its neighborhood...
  47. doi Gene expression of tumour necrosis factor and insulin signalling-related factors in subcutaneous adipose tissue during the dry period and in early lactation in dairy cows
    H Sadri
    Veterinary Physiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
    J Anim Physiol Anim Nutr (Berl) 94:e194-202. 2010
    ..Alternatively, it may indicate that post-transcriptional modifications of these factors came into play and may have concealed an involvement...
  48. pmc Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade
    Ryoyo Ikebuchi
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060 0818, Japan
    Vet Res 42:103. 2011
    ..In a previous report, we showed that, in bovine leukemia virus (BLV) infection, the expression of bovine PD-1 is closely associated with disease progression...
  49. doi SOCS3-mediated blockade reveals major contribution of JAK2/STAT5 signaling pathway to lactation and proliferation of dairy cow mammary epithelial cells in vitro
    Yu Ling Huang
    Key Laboratory of Dairy Science of Education Ministry, Northeast Agricultural University, Harbin 150030, Heilongjiang, China
    Molecules 18:12987-3002. 2013
    ..Here, we used dairy cow mammary epithelial cells (DCMECs) to analyze the function of SOCS3 and the interaction between SOCS3 and STAT5a...
  50. pmc Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization
    Elke Albrecht
    Research Unit Muscle Biology and Growth, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
    PLoS ONE 7:e35282. 2012
    ..study was to characterize the mRNA expression of different ASIP transcripts and of putative targets in different bovine tissues, as well as to study consequences on protein abundance and localization...
  51. doi Adipose tissue angiopoietin-like protein 4 messenger RNA changes with altered energy balance in lactating Holstein cows
    D A Koltes
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Domest Anim Endocrinol 43:307-16. 2012
    ..The consistency and magnitude of the increase in ANGPTL4 mRNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow.
  52. doi Adiponectin deficit during the precarious glucose economy of early lactation in dairy cows
    Sarah L Giesy
    Department of Animal Science, Ithaca, NY 14853, USA
    Endocrinology 153:5834-44. 2012
    ..These data suggest that reduced plasma adiponectin belongs to the subset of hormonal adaptations in EL dairy cows facilitating mammary glucose uptake via promotion of insulin resistance...
  53. doi Proteomic and functional analyses reveal MAPK1 regulates milk protein synthesis
    Li Min Lu
    Key Laboratory of Dairy Science of Education Ministry, Northeast Agricultural University, Harbin 150030, Heilongjiang, China
    Molecules 18:263-75. 2012
    ..proteomic technology was used to identify phosphoproteins responsible for milk protein synthesis in dairy cow mammary epithelial cells (DCMECs)...
  54. pmc A deletion mutation in bovine SLC4A2 is associated with osteopetrosis in Red Angus cattle
    Stacey N Meyers
    Laboratory of Molecular Genetics, Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    BMC Genomics 11:337. 2010
    ..In cattle, osteopetrosis can either be induced during gestation by viral infection of the dam, or inherited as a recessive ..
  55. doi Up-regulation of expression of interferon-stimulated gene 15 in the bovine corpus luteum during early pregnancy
    L Yang
    College of Animal Science and State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China
    J Dairy Sci 93:1000-11. 2010
    ..in ovine CL is speculated to be through an endocrine pathway, but it is unclear whether expression of ISG15 in bovine CL is via such a pathway...
  56. ncbi Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors
    K McGuire
    Division of Genetics and Genomics, Roslin Institute, Roslin, Midlothian, Edinburgh EH25 9PS, UK
    Anim Genet 37:47-50. 2006
    ..TLR1, TLR6 and TLR10 map closely together on Bos taurus chromosome 6 (BTA6), while TLR7 and TLR8 map to the X chromosome...
  57. ncbi The insertion of a full-length Bos taurus LINE element is responsible for a transcriptional deregulation of the Normande Agouti gene
    Michael Girardot
    Unité de Génétique Moléculaire Animale, UMR 1061 INRA Université de Limoges, Limoges, France
    Pigment Cell Res 19:346-55. 2006
    ..This new bovine Agouti allele isolated in Normande breed has been named Abr...
  58. ncbi Cattle and sheep use different promoters to direct the expression of the aromatase cytochrome P450 encoding gene, Cyp19, during pregnancy
    Jens Vanselow
    Research Institute for the Biology of Farm Animals, Research Unit Molecular Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Domest Anim Endocrinol 27:99-114. 2004
    ..All steroidogenic transcripts were detected in ovine and bovine corpus luteum and placenta during pregnancy, however at a very different concentration...
  59. doi Cardiac high molecular weight calmodulin-binding protein is homologous to calpastatin I and calpastatin II
    Nisha Singh
    Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, 103 Hospital Drive, Saskatoon, Saskatchewan, Canada S7N 0W8
    Biochem Biophys Res Commun 373:387-91. 2008
    ..In addition, HMWCaMBP also showed the same affinities for m-calpain as calpastatin I and calpastatin II. Our findings suggest that HMWCaMBP is the homolog of calpastatin and may be a CaM-binding form of calpastatin...
  60. doi The acute-phase protein serum amyloid A3 is expressed in the bovine mammary gland and plays a role in host defence
    Adrian J Molenaar
    Dairy Science and Technology, Ruakura Research Centre, Hamilton, New Zealand
    Biomarkers 14:26-37. 2009
    ..The M-SAA3 mRNA was localized to restricted populations of bovine mammary epithelial cells (MECs)...
  61. ncbi p66shc, but not p53, is involved in early arrest of in vitro-produced bovine embryos
    L A Favetta
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Mol Hum Reprod 10:383-92. 2004
    High embryo loss occurs in the first week of bovine embryo development, with a high percentage of embryonic arrest...
  62. pmc Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein
    Arpita Ray-Sinha
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Mol Membr Biol 26:448-64. 2009
    ..We conclude that a single dibasic degron motif is sufficient to initiate both the ER retention and subsequent degradation of ospin via an ERAD pathway...
  63. ncbi Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1
    Chandreyee Das
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2280, USA
    Virology 318:306-17. 2004
    ..In the related bovine immunodeficiency virus (BIV), Tat recognizes its cognate TAR element with high affinity and specificity in the ..
  64. ncbi TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow?
    T G Berryere
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Anim Genet 34:169-75. 2003
    ..The complete coding sequence of bovine TYRP1 was determined from cDNA derived from skin biopsies of cattle with various colours...
  65. ncbi Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells
    M Osawa
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka Japan
    Eur J Cell Biol 72:229-37. 1997
    ..We have recently reported that a glycoprotein is rapidly tyrosine-phosphorylated in bovine ECs exposed to fluid flow or osmotic shock. Here were cloned a 3...
  66. ncbi The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilage
    P J Neame
    Shriners Hospital for Crippled Children, Tampa, Florida 33612
    J Biol Chem 269:21547-54. 1994
    ..Based on anchored polymerase chain reaction analysis of the mRNA, there is some minor heterogeneity in the position of the 5' end of the message...
  67. ncbi Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    M Uehata
    Discovery Research Tokyo, Yoshitomi Pharmaceutical Industries Ltd, Saitama, Japan
    Nature 389:990-4. 1997
    ..Our findings indicate that p160ROCK-mediated Ca2+ sensitization is involved in the pathophysiology of hypertension and suggest that compounds that inhibit this process might be useful therapeutically...
  68. doi Polymorphisms in the IGF1 gene and their effect on growth traits in Mexican beef cattle
    X F De la Rosa Reyna
    Instituto Politecnico Nacional, Centro de Biotecnología Genómica, Reynosa, Tamaulipas, Mexico
    Genet Mol Res 9:875-83. 2010
    ..in the promoter region (IGF1/SnaBI) has been reported to be associated with production traits in several cattle breeds...
  69. doi Short communication: Effects of the progesterone receptor variants on fertility traits in cattle
    A M Driver
    Department of Dairy Science, University of Wisconsin Madison, Madison, WI 53706, USA
    J Dairy Sci 92:4082-5. 2009
    ..Currently, it is unknown what variants of the PGR gene are related to fertility traits in cattle. Identification of such variants would allow the implementation of marker-assisted selection in breeding schemes...
  70. ncbi Calpain 1-titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril
    Fabrice Raynaud
    Cell Motility Laboratory, EPHE, UMR 5539, UM2, Montpellier, France
    FEBS J 272:2578-90. 2005
    ..Furthermore, calpain 1 is found to localize in myofibril fractures, described as proteolysis sites, in postmortem bovine skeletal red muscles, near the calcium deposits located at the N1 and N2 level...
  71. pmc Ionotropic glutamate receptor AMPA 1 is associated with ovulation rate
    Mayumi Sugimoto
    National Livestock Breeding Center, Nishigo, Japan
    PLoS ONE 5:e13817. 2010
    ..Based on a genome-wide association study in Bos taurus, we found that ovulation rate is influenced by a variation in the N-terminal leucine/isoleucine/valine-binding ..
  72. ncbi Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit
    Jie Zheng
    Howard Hughes Medical Institute, Seattle, WA 98195, USA
    Neuron 36:891-6. 2002
    ..We find, surprisingly, that the channel contains three CNGA1 subunits and only one CNGB1 subunit. These results have implications for CNG channel function in particular and assembly of membrane proteins in general...
  73. doi Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK
    Peter F Mount
    Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia
    Atherosclerosis 200:28-36. 2008
    ..test the hypothesis that bradykinin (BK) regulates AMPK and fatty acid oxidation in endothelium, stimulations of bovine aortic endothelial cells (BAECs) with bradykinin were performed. BK stimulation caused a 2...
  74. ncbi Molecular evidence for a critical period in mural trophoblast development in bovine blastocysts
    Séverine A Degrelle
    UMR INRA ENVA CNRS Biologie du Développement et de la Reproduction, 78352 Jouy en Josas Cedex, France
    Dev Biol 288:448-60. 2005
    ..To provide information on the development of the trophoblast lineage in late-implanting bovine embryos, we combined the use of molecular markers defining embryonic and extra-embryonic lineages in the mouse ..
  75. doi A small set of extra-embryonic genes defines a new landmark for bovine embryo staging
    Séverine A Degrelle
    INRA ENVA, UMR 1198 Biologie du Developpement et Reproduction, Domaine de Vilvert, Jouy en Josas, France
    Reproduction 141:79-89. 2011
    ..To this end, we have profiled bovine extra-embryonic tissues at peri-implantation stages, when gastrulation and early neurulation occur, and analysed ..
  76. ncbi Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1
    Jun Cai
    School of Optometry and Vision Sciences, Cardiff University, UK
    J Biol Chem 281:3604-13. 2006
    ..This confirms the importance of PEDF and VEGFR-1 in the negative regulation of angiogenesis...
  77. ncbi Polymorphism in genes of growth hormone receptor (GHR) and insulin-like growth factor-1 (IGF1) and its association with both the IGF1 expression in liver and its level in blood in Polish Holstein-Friesian cattle
    Andrzej Maj
    Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05 552 Wolka Kosowska, Poland
    Neuro Endocrinol Lett 29:981-9. 2008
    ..Ghr and igf1 genes have been associated with milk and meat production of cattle. However, the molecular and physiological mechanisms underlying such associations are unknown...
  78. ncbi Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils
    M E Selsted
    Department of Pathology, College of Medicine, University of California, Irvine 92717
    J Biol Chem 268:6641-8. 1993
    A new family of cysteine-rich antimicrobial peptides from bovine neutrophils was isolated and characterized...
  79. pmc Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle
    D E Shuster
    U S Department of Agriculture, Agricultural Research Service, Ames, IA
    Proc Natl Acad Sci U S A 89:9225-9. 1992
    Two point mutations were identified within the gene encoding bovine CD18 in a Holstein calf afflicted with leukocyte adhesion deficiency (LAD)...
  80. ncbi Complete genomic sequence of the bovine prion gene (PRNP) and polymorphism in its promoter region
    D Hills
    Division of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
    Anim Genet 32:231-2. 2001
  81. ncbi Cloning of the bovine prion-like Shadoo (SPRN) gene by comparative analysis of the predicted genomic locus
    Cristina Uboldi
    Department of Genetics and Microbiology A Buzzati Traverso, University of Pavia, Pavia, Italy
    Mamm Genome 17:1130-9. 2006
    ..We mapped SPRN in Bos taurus by comparative analysis of the locus and of the predicted flanking genes...
  82. doi Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-κB p65 and C/EBPβ in mammary epithelial cells
    Shuzhen Liu
    University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Mol Immunol 48:895-908. 2011
    ..in MEC the role of NF-κB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle. Abrogating NF-κB binding to that site by introduction of a single point mutation blocks promoter activity of ..
  83. pmc Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus, Bos indicus, and composite cattle
    Brian W Brunelle
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010 USA
    BMC Vet Res 4:36. 2008
    ..These factors have been extensively studied in breeds of Bos taurus cattle in relation to classical bovine spongiform encephalopathy (BSE)...
  84. pmc Bovine insulin filaments induced by reducing disulfide bonds show a different morphology, secondary structure, and cell toxicity from intact insulin amyloid fibrils
    Tamotsu Zako
    Bioengineering Laboratory, RIKEN Institute, Saitama, Japan
    Biophys J 96:3331-40. 2009
    ..We demonstrate here that bovine insulin forms flexible filaments in the presence of a reducing agent, Tris (2-carboxyethyl) phosphine...
  85. doi Indels within promoter and intron 1 of bovine prion protein gene modulate the gene expression levels in the medulla oblongata of two Japanese cattle breeds
    G Msalya
    Kagoshima University, Japan
    Anim Genet 41:218-21. 2010
    ..In cattle, however, none of the known coding polymorphisms has a direct effect on bovine spongiform encephalopathy (BSE)...
  86. doi Novel mutations of the FASN gene and their effect on fatty acid composition in Japanese Black beef
    Tsuyoshi Abe
    National Livestock Breeding Center, 1 Odakurahara, Nishigo, Fukushima, Japan
    Biochem Genet 47:397-411. 2009
    ..coding sequence of the bovine fatty acid synthase (FASN) gene of an F2 population from Japanese Black and Limousin cattle. Two mutations, g.16024A>G and g...
  87. doi Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle
    Jyothsna Tejomurtula
    Division of Animal and Nutritional Sciences, Laboratory of Animal Biotechnology and Genomics, West Virginia University, Morgantown, West Virginia 26506, USA
    Biol Reprod 81:333-42. 2009
    ..Through analysis of expressed sequence tags from a bovine oocyte cDNA library, we identified a new member of the importin alpha family (named importin alpha8)...
  88. ncbi Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel
    U B Kaupp
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    Nature 342:762-6. 1989
    The complete amino-acid sequence of the cyclic GMP-gated channel from bovine retinal rod photoreceptors, deduced by cloning and sequencing its complementary DNA, shows that the protein contains several putative transmembrane segments, ..
  89. pmc Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese black cattle
    Shogo Hoashi
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Nada, Kobe, Japan
    BMC Genet 9:84. 2008
    ....
  90. pmc How the regulatory protein, IF(1), inhibits F(1)-ATPase from bovine mitochondria
    Jonathan R Gledhill
    Medical Research Council Dunn Human Nutrition Unit, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 104:15671-6. 2007
    The structure of bovine F(1)-ATPase inhibited by a monomeric form of the inhibitor protein, IF(1), known as I1-60His, lacking most of the dimerization region, has been determined at 2.1-A resolution...
  91. ncbi Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcripts
    U Wissenbach
    Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, Homburg Saar, Germany
    FEBS Lett 429:61-6. 1998
    ..Complementary DNA was isolated from a bovine testis cDNA library which encodes bovine trp2 (btrp2), a protein of 432 amino acid residues comprising four ..
  92. doi The major protein of bovine seminal plasma, PDC-109, is a molecular chaperone
    Rajeshwer Singh Sankhala
    School of Chemistry, University of Hyderabad, Hyderabad 500046, India
    Biochemistry 49:3908-18. 2010
    The major protein of bovine seminal plasma, PDC-109, binds to choline phospholipids on the sperm plasma membrane and induces the efflux of cholesterol and choline phospholipids, which is an important step in sperm capacitation...
  93. doi Effect of VEGF (vascular endothelial growth factor) on expression of IL-8 (interleukin-8), IL-1beta and their receptors in bovine theca cells
    Chiaki Murayama
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Cell Biol Int 34:531-6. 2010
    ..receptors, CXCR1 and IL-1R1 in the theca cells of PRF (preselection) and POF (postselection follicles) from the bovine ovary...
  94. doi Molecular characterization of the DDX3Y gene and its homologs in cattle
    W S Liu
    Department of Dairy and Animal Science, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Cytogenet Genome Res 126:318-28. 2009
    ..Here, we report the characterization of the bovine (b) DDX3Y gene and its homologs DDX3X and PL10...
  95. ncbi Organization and concerted evolution of the ampliconic Y-chromosomal TSPY genes from cattle
    Edward L C Verkaar
    Faculty of Veterinary Medicine, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Genomics 84:468-74. 2004
    ..Analysis of bovine BAC clones leads to an estimate of 90 TSPY loci on the bovine Y chromosome...
  96. ncbi IGF2 gene characterization and association with rib eye area in beef cattle
    J J Goodall
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, SK S7N 5A8, Canada
    Anim Genet 38:154-61. 2007
    ..factor 2 (IGF2) is an imprinted gene expressed in most tissues affecting lean muscle content in mice, pigs and cattle. We previously identified the bovine IGF2 c.-292C>T SNP in the non-translated exon 2...
  97. doi AluI polymorphism of the bovine growth hormone (GH) gene, resumption of ovarian cyclicity, milk production and loss of body condition at the onset of lactation in dairy cows
    O Balogh
    Faculty of Veterinary Science, Szent Istvan University, 1078 Budapest István u 2, Hungary
    Theriogenology 71:553-9. 2009
    ..We concluded that, under field conditions, AluI polymorphism of the bovine GH gene had no effect on the interval from calving to first ovulation and could not be directly related to ..
  98. pmc Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease
    Sujuan Xu
    Center for Advanced Biotechnology and Medicine, Department of Biochemistry, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 282:23525-31. 2007
    ..Here we report the crystal structure of bovine NPC2 bound to cholesterol-3-O-sulfate, an analog that binds with greater apparent affinity than cholesterol...
  99. ncbi Genomic structure and transcript variants of the bovine DAZL gene
    W S Liu
    Department of Animal Biotechnology, College of Agriculture, Biotechnology and Natural Resources, University of Nevada, Reno, NV 89557, USA
    Cytogenet Genome Res 116:65-71. 2007
    ..In the present study, we have cloned and characterized the bovine DAZL (bDAZL) gene...

Research Grants78

  1. Biochemical Detection of Prions in Blood
    Joaquin Castilla; Fiscal Year: 2005
    ..outbreak of Bovine Spongiform Encephalopathy and Chronic Wasting disease and the transmission of the disease from cattle to humans have risen a great concern about a possible epidemic of Creutzfeldt-Jakob disease...
  2. S. typhimurium Genes Required for Colonization of Cattle
    Helene Andrews Polymenis; Fiscal Year: 2004
    ..typhimurium variants (phage types DT2 and DT99) that cause fatal pigeon paratyphoid do not persist in cattle. The objective of this proposal is to identify the genes responsible for the epidemiologic success of S...
  3. Antibodies and Congenital Neospora Caninum Transmission
    GARY HALDORSON; Fiscal Year: 2004
    ..Transplacental transmission of neospora caninum results in abortions, stillbirths, and congenital infection in cattle and dogs. This apicomplexan parasite is similar to Toxoplasma gondii and Plasmodium sp...
  4. Method validation and comparison for the detection of mycotoxins in novel animal
    Lisa Murphy; Fiscal Year: 2013
    ..If the Charm ROSA-M readers can be validated for the analysis of dog food, cattle feed, and swine feed, they will provide an easy method for minimally-trained personnel at multiple laboratories to ..
  5. Novel High Affinity and Long-Acting Bovine FSH Analogs for Veterinary Superovulat
    BRUCE DALE WEINTRAUB; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bovine ovarian superovulation is the current state-of-the-art method employed worldwide to maintain and improve milk and beef production through genetic selection of the best quality breeders and best ..
  6. Parameters that govern initiation of VSG switching in T.brucei
    F Nina Papavasiliou; Fiscal Year: 2013
    ..The parasite Trypanosoma brucei is the causative agent of African sleeping sickness in humans and of Nagana in cattle, and one of the leading impediments to development in much of sub-Saharan Africa. T...
  7. "Physical and Chemical Cues that Guide Sperm Migration"
    Mingming Wu; Fiscal Year: 2013
    ..For this project, the bovine model will not only provide useful information to the cattle industry but also to human medicine, because ..
  8. Identifying components of Toxoplasma oocysts that confer environmental resistance
    HEATHER MICHELLE FRITZ; Fiscal Year: 2013
    ..g. swine, cattle, sheep) containing bradyzoite tissue cysts, or through congenital transmission...
  9. Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigen
    Ana M Espino; Fiscal Year: 2013
    ..hepatica causes liver fluke disease or fascioliasis, thereby affecting the health of humans, as well as sheep, cattle and goats, among others mammalians. Fascioliasis causes losses in agriculture estimated at >US3...
  10. Epigenetic control of preimplantation embryo development
    Pablo Juan Ross; Fiscal Year: 2013
    ..Early embryonic mortality is a major cause of infertility in dairy cattle and humans...
  11. Mechanisms of prion aggregation and species barriers
    Christina Sigurdson; Fiscal Year: 2013
    ..Zoonotic prion transmission is of concern, as the bovine spongiform encephalopathy (BSE) epidemic has led to nearly 200 cases of prion infection in humans...
  12. Cyclic Amplification of Prion Protein Misfolding
    Claudio Soto; Fiscal Year: 2013
    ..Although rare diseases, the recent outbreak of Bovine Spongiform Encephalopathy and Chronic Wasting disease and the transmission of the disease from cattle to humans ..
  13. Liposome-siRNA-Peptide Complexes as Therapy to Cure Prion Diseases in Mouse Model
    Mark D Zabel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Transmissible spongiform encephalopathies (TSEs) include scrapie in sheep;bovine spongiform encephalopathy (BSE) in cattle;chronic wasting disease (CWD) in deer and elk;and Kuru and Creutzfeldt-Jakob ..
  14. SdiA regulation of EHEC virulence
    Vanessa Sperandio; Fiscal Year: 2013
    ..The main reservoir for EHEC is cattle herds...
  15. Assembly of a Dodecahedral Virus
    Adam Zlotnick; Fiscal Year: 2013
    ..BEV is non-pathogenic even in cattle, where it is endemic...
  16. Characterize functions of T. brucei RAP1 and TRF in antigenic variation and telom
    Bibo Li; Fiscal Year: 2013
    ..applicant): Trypanosoma brucei is a protozoan parasite that causes African trypanosomiasis in humans and nagana in cattle. In mammalian hosts, bloodstream form (BF) T...
  17. Artiodactyl Gene Modification with Tal Effector Nucleases
    SCOTT CHRISTOPHER FAHRENKRUG; Fiscal Year: 2012
    ..studies proposed here will establish a new paradigm for the genetic modification of artiodactyls (pigs, sheep, and cattle) for use as large animal models of human disease and the production of biomedical materials...
  18. Pathogenesis, Transmission and Detection of Zoonotic Prion Diseases (P01)
    Claudio Soto; Fiscal Year: 2012
    ..Although rare, the recent outbreak of Bovine Spongiform Encephalopathy(BSE) in cattle and Chronic Wasting disease (CWD) in cervids and the transmission of the disease from cattle to humans have caused ..
  19. Investigation of Occupational Exposure to and Infection by MRSA in Rural Iowa
    Tara Smith; Fiscal Year: 2012
    ..We will examine 30 farms during this research, including farms with live swine, cattle, and poultry. In the second part of our research plan, we will examine transmission of S...
  20. Evidence based control strategies of Sleeping Sickness vectors
    Serap Aksoy; Fiscal Year: 2012
    ..is at risk of HAT outbreaks due to ongoing epidemics in neighboring Uganda and increased movement of people and cattle (known reservoirs for Trypanosoma brucei rhodesiense)...
  21. Key molecular mechanisms of extraneural pathogenesis and transmission of TSEs
    Mark D Zabel; Fiscal Year: 2012
    ..include chronic wating disease (CWD) of deer and elk, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jacob disease and kuru in humans...
  22. Molecular Mechanisms of Prion and Amyloid Propagation
    Christopher P Jaroniec; Fiscal Year: 2013
    ..a group of fatal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle...
  23. Mechanisms of Resistance and Susceptibility to African Trypanosome Infection
    Stephen L Hajduk; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma brucei brucei causes Nagana in cattle but is non-infectious to humans because of its susceptibility to the cytotoxic activity of normal human serum...
  24. Development of a Biochemical Diagnosis for Creutzfeldt-Jakob disease
    Claudio Soto; Fiscal Year: 2013
    ..sCJD), the most common form, and variant CJD (vCJD) which is associated to consumption of cattle meat infected by bovine spongiform encephalopathy...
  25. Lysosomal biogenesis and function in African trypanosomes
    James D Bangs; Fiscal Year: 2013
    ..are parasitic protozoa that cause human African trypanosomiasis (HAT, sleeping sickness), as well as nagana in cattle and other livestock...
  26. One Health Innovation Fellowships for Zoonotic Disease Research In Mongolia
    GREGORY CHARLES GRAY; Fiscal Year: 2013
    ..Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle. Large segments of the normally nomadic pastoral populations have begun migrating to urban areas and introducing ..
  27. Phosphoinositides in the T. brucei Endomembrane System
    Julia K Gilden; Fiscal Year: 2013
    ..protozoa responsible for causing human African trypanosomiasis (HAT, sleeping sickness) in humans and nagana in cattle and other livestock...
  28. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng George Wang; Fiscal Year: 2013
    ..coli fermentation. Such a bioconjugate already offers good possibility to be used to induce antibodies in cows or cattle to kill an inoculum of E. coli O157, since the vaccines can be produced in large scale economically...
  29. High Throughput Screening for Foot and Mouth Disease Virus Antivirals
    John F Atkins; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The infection of cattle with Foot and Mouth Disease Virus (FMDV) causes not only great economic damage but great popular panic, e.g...
  30. Missouri Food Safety Council Initiative
    LINDA HICKAM; Fiscal Year: 2013
    ..Missouri's agricultural diversity includes 107,825 farms, 3 million swine, over 3 million cattle, 4,448 egg retailers, 764 egg dealers, 8 processors, as well as 1,445 total permitted and licensed dairy farms, ..
  31. Structure and assembly of the fungal prion HET-s
    William N Wan; Fiscal Year: 2013
    ..TSEs include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer and elk, and several forms of ..
  32. System biology approach to understand endometrial receptivity &pregnancy loss
    Thomas E Spencer; Fiscal Year: 2013
    ..endometrial receptivity an pregnancy success, which will increase production efficiency and profitability of cattle enterprises...
  33. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2013
    ..Importantly, protective immunity against Ov larvae has now been definitively demonstrated in humans, cattle and mice, thereby proving the conceptual underpinnings that a vaccine can be produced against this infection...
  34. Development of a Novel Rift Valley Fever Virus Vaccine
    Shinji Makino; Fiscal Year: 2013
    ..disease of sub-Saharan Africa that can emerge in explosive mosquito-borne epidemics, decimating herds of sheep and cattle and resulting in enormous economic losses;humans are infected concurrently, and their infection results in ..
  35. Environmental Health Specialist Network
    RICHARD NORMAN DANILA; Fiscal Year: 2013
    ..specific questions about well water and other exposures), and application of GIS using data sources such as cattle density, geologic sensitivity to groundwater contamination, and climate variables (e.g., flooding)...
  36. Tuberculosis epidemiology and novel transmission routes in rural Tanzania
    Philip C Hopewell; Fiscal Year: 2013
    ..livestock keepers (pastoralists) combined with poor public health infrastructure, limited TB control measures for cattle and animal products, and a large immunocompromised human population due to HIV/AIDS, make Africa particularly ..
  37. Enhanced inspection and surveillance testing of cattle feeds in NY State
    Daniel Rice; Fiscal Year: 2013
    ..If funded we propose to expand the inspection and surveillance testing of cattle feeds and feed ingredients manufactured and distributed in NY State...
  38. Feed Safety and BSE/Ruminant Feed Ban Support Project (U18)
    CLAUDIA G COLES; Fiscal Year: 2013
    ..WSDA describes Washington State's vulnerability to BSE agent release from imported Canadian cattle in age cohorts shared by the ongoing BSE positives identified by Canadian BSE surveillance...
  39. EVC2: A novel modulator in tooth development
    Yoshiyuki Mochida; Fiscal Year: 2013
    ..A causative gene, LIMBIN for bovine chondrodysplastic dwarfism (bcd) found in Japanese brown cattle was later identified as the bovine ortholog of ..
  40. Mechanisms underlying myostatin regulation and activity
    Se Jin Lee; Fiscal Year: 2013
    ..Subsequent genetic studies in cattle, sheep, dogs, and humans have all shown that the function of myostatin as a negative regulator of muscle mass has ..
  41. Immunogenicity of the Type IV Secretin System
    WENDY CATHERINE BROWN; Fiscal Year: 2012
    ..By testing cattle that express a diverse repertoire of class II haplotypes, representative of the diversity of MHC class II ..
  42. RNA CAPPING IN TRYPANOSOMES
    Christian Tschudi; Fiscal Year: 2012
    ..agents of African trypanosomiasis or sleeping sickness in humans and a wasting and fatal disease (Nagana) in cattle, domestic pigs and other farm animals causing a profound effect on the economy of much of the continent...
  43. Characterization of prion protein conformational changes
    VALERIE D DAGGETT; Fiscal Year: 2010
    ..disease, fatal familial insomnia and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer and elk. While rare, these diseases are always fatal...
  44. Assessing the Transmissibility of CWD to Humans
    Qingzhong Kong; Fiscal Year: 2010
    ..be transmitted to humans directly (Aim 1)? Can CWD be transmitted to humans after passage through secondary hosts (cattle or sheep) (Aim 2)? Has CWD transmission to humans already occurred (Aim 3)? The ultimate goals are to define the ..
  45. Structural basis of species-specific infectivities of two prion strains
    Peter M Tessier; Fiscal Year: 2010
    ..infectious proteins that cause devastating neurodegenerative diseases (transmissible encephalopathies) in humans, cattle and other mammals...
  46. REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEI
    Ching Wang; Fiscal Year: 2009
    ..are the causative pathogens of spp., African sleeping sickness in humans and nagana in cattle. They are a family of sickness in humans and nagana in cattle...
  47. Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrhea
    Linda J Saif; Fiscal Year: 2010
    ..of state-of-the-art technology for diagnosis (assays, reagents) and treatments (vaccines) for RV infections of cattle, the major agricultural commodity in Argentina...
  48. 2009 Spirochetes, Biology of
    David A Haake; Fiscal Year: 2010
    ..including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been very difficult to study...
  49. Preventing Human Prion Diseases - Inactivation of Prions
    Stanley B Prusiner; Fiscal Year: 2010
    ..plan to study three strains of prions passaged in mice: RML and 301V, which originated from sheep with scrapie and cattle with BSE, respectively, plus a novel synthetic strain MoSP1, which is the most stable strain reported to date...
  50. Characterization of de novo generation of infectious prions
    Joaquin Castilla; Fiscal Year: 2009
    ..The occurrence of spontaneous cases of prion diseases in humans (sporadic CJD) and in other species, i.e. Bovine spongiform encephalopathy (BSE) in US cattle and Nor98 (atypical scrapie) in New Zealand sheep, provide evidence ..
  51. MARKERS OF HUMAN INFECTION WITH BOVINE LEUKEMIA VIRUS
    GERTRUDE BUEHRING; Fiscal Year: 2007
    ..Bovine leukemia virus (BLV), an oncogenic retrovirus, causes widespread infection of cattle globally...
  52. Regulation of osteoclast biology by anion exchanger SLC4A2 in mouse and human sys
    Antonios O Aliprantis; Fiscal Year: 2013
    ..A recent publication has identified a nearly identical phenotype in cattle that lack SLC4A2...
  53. LYMPHOCYTE-MEDIATED IMMUNITY TO ANAPLASMA MARGINALE
    Reginald Valdez; Fiscal Year: 1999
    ..There was some uncertainty as to the extent of the problem of acute anaplasmosis infection in cattle and how the research findings might impact the field. Since Dr...
  54. Role of Fetal Steroids in Formation and Activation of Bovine Ovarian Follicles
    Joanne E Fortune; Fiscal Year: 2010
    ..We have developed experimental models in which formation of bovine primordial follicles and development of their capacity to activate (i.e...
  55. Mechanism of membrane permeabilization by a cytolytic high density lipoprotein
    JOHN MATTHEW HARRINGTON; Fiscal Year: 2010
    ..innate immunity against the mammalian parasite Trypanosoma brucei brucei, the causative agent of Nagana in African cattle. The morphologically indistinct T. brucei subspecies T. b. rhodesiense and T. b...
  56. The role of Variable Erythrocyte Surface Antigen (VESA1) proteins in Babesia bovi
    KERRY SUE SONDGEROTH; Fiscal Year: 2011
    ..This project will use Babesia bovis infection of cattle as a natural animal model of cytoadherence and virulence, and will address a significant knowledge gap to ..
  57. Structural Characterization of Prion Isoforms in Multiple TSE Diseases
    MICHELE ANN MCGUIRL; Fiscal Year: 2012
    ..Familial Insomnia, and kuru (humans), scrapie (sheep), chronic wasting disease (elk, deer), and mad cow disease (cattle)...
  58. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ..The incidence of immune-mediated abortion and placental insufficiency in both humans and cattle are greatly increased with the use of assisted reproductive technologies such as in vitro fertilization...
  59. SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTING
    Shinichiro Kurosawa; Fiscal Year: 2011
    ..There are certain strains of dangerous E. coli bacteria that can infect crops or cattle, and can be transmitted through our food distribution system to thousands of households...
  60. REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEI
    CHING CHUNG WANG; Fiscal Year: 2012
    ..are the causative pathogens of African sleeping sickness in humans and nagana in cattle. They are a family of deeply branched eukaryotes that exhibit many unique features during their cell cycle ..
  61. A Phase I Study to Evaluate the Safety and Immunogenicity of HPV 16 L2 11-200
    WARNER KING HUH; Fiscal Year: 2012
    ..Vaccination of cattle with bovine papillomavirus type 4 (BPV4) L2 11-200 protects against BPV4 challenge on the soft palate...
  62. Epigenetic Modulation of PTPG by Zeranol in Beef Increases Breast Cancer Risk
    Young C Lin; Fiscal Year: 2010
    ..The overall HYPOTHESIS to be evaluated is that the consumption of beef products, derived from Z-implanted beef cattle may possess a potential health impact on human consumers, particularly with respect to reproductive endocrinology ..
  63. Point-of-Care Diagnostic Assay for Direct Detection of Pathogenic Leptospira
    Jeffrey Smith; Fiscal Year: 2010
    ..The World Health Organization lists the groups of people at risk of the infection ranging from cattle and pig farmers to veterinarians, butchers and slaughterhouse workers to children playing in rain puddles or mud, ..
  64. Impact of Microparticles on Oral TSE Infections
    Joel A Pedersen; Fiscal Year: 2012
    ..Microparticles are found in many other substances than soil. Meat and bone meal (MBM), a commonly used cattle food supplement thought responsible for BSE in Europe...
  65. ANALYSIS OF TRYPANOSOME MRNA SYNTHESIS BY GENE TRANSFER
    Vivian Bellofatto; Fiscal Year: 2010
    ..In Africa, Trypanosoma brucei ssp. infect humans and domestic cattle, causing African sleeping sickness and Nagana, respectively. Human infection by the subspecies T. b...
  66. LATENCY AND LEUKOMOGENICITY OF BOVINE LEUKEMIA VIRUS
    Gary Cockerell; Fiscal Year: 1991
    b>Bovine leukemia virus (BLV) is an important, naturally occurring, endermic, retroviral disease of cattle, and a valuable comparative biomedical animal model of analogous human T cell lymphotropic retroviral (HTLV) infections...
  67. Michigan Food, Feed and Animal Health Protection
    APRIL DAWN HUNT; Fiscal Year: 2013
    ..The activities include: 1) reducing drug tissue residue violations in dairy cattle through a Hazard Analysis and Critical Control Points (HACCP) based approach;2) developing best practices for an ..
  68. REGULATION OF OTP-1 AND HCG GENES IN OVINE TROPHOBLAST
    George Seidel; Fiscal Year: 1993
    ..that communicate its presence to the mother have been identified: in sheep, ovine trophoblast protein-1 (oTP-1); cattle, (bTP- 1); and humans, human chorionic gonadotropin (hCG)...
  69. IDENTIFICATION OF BABESIA IMMUNOGENS WITH TH CEL
    Wendy Brown; Fiscal Year: 2000
    ..Immunoregulatory mechanisms in cattle are much more like those of humans than mice, so this outbred large animal species provides an alternative system ..
  70. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    R Roberts; Fiscal Year: 1999
    ..the number of functional genes for the embryonic IFN'S, ovine trophoblast protein-1 (oTP-1) and the related bovine protein, bTP-1, by Southern blotting procedures with CDNA probes that will distinguish these IFN's from related ..
  71. Biosensor for Rapid Detection of Prion
    Thomas Hazel; Fiscal Year: 2005
    ..and Bovine Spongiform Encephalopathy are transmissible, neurodegenerative and fatal prion diseases of humans and cattle, respectively...
  72. MODELS OF HYPOXIC PULMONARY HYPERTENSION
    Archibald Alexander; Fiscal Year: 1980
    ..This response to hypoxia which occurs in most mammalian species including man, is particularly pronounced in cattle and also marked in swine...
  73. Producing Polyclonal Human Antibodies to Anthrax
    Thillainayagam Sathiyaseelan; Fiscal Year: 2005
    ..Hematech is developing a genetically modified line of cattle that will produce human instead of bovine immunoglobulin...
  74. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
    ..fluid inactivation) process inactivates enveloped viruses such as MuLV, VSV, TGE, BVD, Sindbis and HIV in fetal bovine serum by a lipid solubilization mechanism, similar to the solvent detergent method...
  75. Molecular Modulation of Catalytic Sites of Escherichia coli F1Fo ATP Synthase
    Zulfiqar Ahmad; Fiscal Year: 2009
    ..b>Bovine X-ray crystal structure of catalytic sites indicates the presence of some other residues which seem to be involved ..
  76. Receptor/Ligand Signals for Ovarian Follicular Angiogenesis
    Leon J Spicer; Fiscal Year: 2010
    ..In preliminary studies using experimental paradigms developed in our bovine granulosa and theca cell model, we demonstrated that: 1) abundance of ANG and FGF9 mRNA in bovine granulosa cells ..
  77. NEUROCHEMICAL CORRELATES OF CEREBELLAR DEVELOPMENT
    Andrej Rotter; Fiscal Year: 1992
    The aim of this proposal is to study the expression gamma-aminobutyric acid/benzodiazepine (GABA/BZ) receptors in bovine and murine cerebellum during development...
  78. QTL and QTL Genes Underlying Lactation Performance
    Darryl L Hadsell; Fiscal Year: 2010
    ..Despite these findings, however, the genes that contribute to milk production are largely unidentified. In the bovine, there are quantitative trait loci (QTL) for milk volume present on all 29 autosomes...