cow

Summary

Alias: domestic cow, domestic cattle, cattle, bovine, Bos taurus, Bos primigenius taurus, Bos bovis, Bos Tauurus, Bovidae sp. Adi Nefas

Top Publications

  1. pmc Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition
    F X Liang
    Epithelial Biology Unit, The Ronald O Perelmen Department of Dermatology, New York University Medical School, New York, NY 10016, U S A
    Biochem J 355:13-8. 2001
  2. ncbi Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition
    Bernard Grisart
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 4000 Liege, Belgium
    Genome Res 12:222-31. 2002
  3. ncbi Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle
    R Kambadur
    AgResearch, Ruakura, Hamilton, New Zealand
    Genome Res 7:910-6. 1997
  4. pmc Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content
    Andreas Winter
    Lehrstuhl für Tierzucht der Technischen Universität München, 85350 Freising Weihenstephan, Germany
    Proc Natl Acad Sci U S A 99:9300-5. 2002
  5. pmc Dissection of genetic factors modulating fetal growth in cattle indicates a substantial role of the non-SMC condensin I complex, subunit G (NCAPG) gene
    Annett Eberlein
    Research Unit Molecular Biology, Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    Genetics 183:951-64. 2009
  6. pmc ZNF280BY and ZNF280AY: autosome derived Y-chromosome gene families in Bovidae
    Yang Yang
    Department of Dairy and Animal Science, The Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 12:13. 2011
  7. ncbi Bovine prion protein gene (PRNP) promoter polymorphisms modulate PRNP expression and may be responsible for differences in bovine spongiform encephalopathy susceptibility
    Petra Sander
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine, Hannover, Germany
    J Biol Chem 280:37408-14. 2005
  8. ncbi A bovine homologue of the human TSPY gene
    S Jakubiczka
    Institut fur Humangenetik, Medizinische Hochschule Hannover, Germany
    Genomics 17:732-5. 1993
  9. ncbi Assessment of positional candidate genes myf5 and igf1 for growth on bovine chromosome 5 in commercial lines of Bos taurus
    C Li
    Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    J Anim Sci 82:1-7. 2004
  10. ncbi Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
    M Amano
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 01
    J Biol Chem 271:20246-9. 1996

Detail Information

Publications320 found, 100 shown here

  1. pmc Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition
    F X Liang
    Epithelial Biology Unit, The Ronald O Perelmen Department of Dermatology, New York University Medical School, New York, NY 10016, U S A
    Biochem J 355:13-8. 2001
    ..Taken together, these results indicate that uroplakins form a tightly packed structure, that the four uroplakins interact specifically forming two pairs, and that both uroplakin pairs are required for normal urothelial plaque formation...
  2. ncbi Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition
    Bernard Grisart
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 4000 Liege, Belgium
    Genome Res 12:222-31. 2002
    ..trait locus (QTL) with a major effect on milk composition--particularly fat content--to the centromeric end of bovine chromosome 14...
  3. ncbi Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle
    R Kambadur
    AgResearch, Ruakura, Hamilton, New Zealand
    Genome Res 7:910-6. 1997
    ..mh), commonly known as double muscling, occurs with high frequency in the Belgian Blue and Piedmontese cattle breeds...
  4. pmc Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content
    Andreas Winter
    Lehrstuhl für Tierzucht der Technischen Universität München, 85350 Freising Weihenstephan, Germany
    Proc Natl Acad Sci U S A 99:9300-5. 2002
    ..Our mapping studies placed DGAT1 close to the region of a quantitative trait locus (QTL) on bovine chromosome 14 for variation in fat content of milk...
  5. pmc Dissection of genetic factors modulating fetal growth in cattle indicates a substantial role of the non-SMC condensin I complex, subunit G (NCAPG) gene
    Annett Eberlein
    Research Unit Molecular Biology, Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    Genetics 183:951-64. 2009
    ..Merging our data with results from other cattle populations differing in historical and geographical origin and with comparative data from human whole-genome ..
  6. pmc ZNF280BY and ZNF280AY: autosome derived Y-chromosome gene families in Bovidae
    Yang Yang
    Department of Dairy and Animal Science, The Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 12:13. 2011
    ..These transpositions are lineage-dependent. The purpose of this study is to investigate the lineage-specific Y-chromosome genes in bovid...
  7. ncbi Bovine prion protein gene (PRNP) promoter polymorphisms modulate PRNP expression and may be responsible for differences in bovine spongiform encephalopathy susceptibility
    Petra Sander
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine, Hannover, Germany
    J Biol Chem 280:37408-14. 2005
    ..within the bovine PRNP gene have little or no effect on bovine spongiform encephalopathy (BSE) susceptibility in cattle. We have recently found a tentative association between PRNP promoter polymorphisms and BSE susceptibility in ..
  8. ncbi A bovine homologue of the human TSPY gene
    S Jakubiczka
    Institut fur Humangenetik, Medizinische Hochschule Hannover, Germany
    Genomics 17:732-5. 1993
    We have isolated a male-specific bovine genomic homologue of the human TSPY gene (testis-specific protein, Y-encoded). Two specific transcripts can be detected in bovine testicular RNA...
  9. ncbi Assessment of positional candidate genes myf5 and igf1 for growth on bovine chromosome 5 in commercial lines of Bos taurus
    C Li
    Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    J Anim Sci 82:1-7. 2004
    ..BWT), preweaning average daily gain (PWADG), and average daily gain on feed (ADGF) in commercial lines of Bos taurus. The QTL regions for the growth traits identified using a haplotype association analysis, which included the ..
  10. ncbi Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
    M Amano
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 01
    J Biol Chem 271:20246-9. 1996
    ..The activated Rho-kinase subsequently phosphorylates MLC. This may partly account for the mechanism by which Rho regulates cytokinesis, cell motility, or smooth muscle contraction...
  11. ncbi Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder
    Wei Yang
    Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Mol Immunol 45:1385-97. 2008
    ..We examined here, if inadequate activation of the bovine TLR2 and TLR4 pathogen receptors by ligands derived from S...
  12. pmc Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking
    Yasuko Iwakiri
    Section of Digestive Diseases, Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 103:19777-82. 2006
    ..These data indicate that local NOS action generates organelle-specific protein S-nitrosylation reactions that can regulate intracellular transport processes...
  13. ncbi Identification and expression of Toll-like receptors 1-10 in selected bovine and ovine tissues
    Moira Menzies
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Vet Immunol Immunopathol 109:23-30. 2006
    ..The main goal of this study was to determine if homologues of human TLRs 1-10 exist within the cattle and sheep...
  14. ncbi Nitric oxide activates TRP channels by cysteine S-nitrosylation
    Takashi Yoshida
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    Nat Chem Biol 2:596-607. 2006
    ..These findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families...
  15. pmc High-efficiency utilization of the bovine integrin alpha(v)beta(3) as a receptor for foot-and-mouth disease virus is dependent on the bovine beta(3) subunit
    S Neff
    Foot and Mouth Disease Research Unit, USDA Agricultural Research Service, Plum Island Animal Disease Center, Greenport, New York 11944, USA
    J Virol 74:7298-306. 2000
    We have previously reported that Foot-and-mouth disease virus (FMDV), which is virulent for cattle and swine, can utilize the integrin alpha(v)beta(3) as a receptor on cultured cells...
  16. pmc Hydrogen peroxide is the major oxidant product of xanthine oxidase
    Eric E Kelley
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Free Radic Biol Med 48:493-8. 2010
    ..Furthermore, XO bound to glycosaminoglycans on the apical surface of bovine aortic endothelial cells demonstrated a similar ROS production profile...
  17. ncbi Modulation of the oligomerization state of the bovine F1-ATPase inhibitor protein, IF1, by pH
    E Cabezon
    Medical Research Council Dunn Human Nutrition Unit, Cambridge, United Kingdom
    J Biol Chem 275:25460-4. 2000
    b>Bovine IF(1), a basic protein of 84 amino acids, is involved in the regulation of the catalytic activity of the F(1) domain of ATP synthase. At pH 6.5, but not at basic pH values, it inhibits the ATP hydrolase activity of the enzyme...
  18. ncbi Crystal structure of rhodopsin: A G protein-coupled receptor
    K Palczewski
    Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
    Science 289:739-45. 2000
    ..Identification of a set of residues that mediate interactions between the transmembrane helices and the cytoplasmic surface, where G-protein activation occurs, also suggests a possible structural change upon photoactivation...
  19. doi Copy number variation of testis-specific protein, Y-encoded (TSPY) in 14 different breeds of cattle (Bos taurus)
    C K Hamilton
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Sex Dev 3:205-13. 2009
    ..Previous studies have estimated that TSPY ranges from 50-200 copies in cattle. To examine TSPY localization on the Y chromosome we employed fluorescence in situ hybridization (FISH) and fiber-..
  20. doi Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81
    Changlu Liu
    Johnson and Johnson Pharmaceutical Research and Development LLC, San Diego, CA 92121, USA
    J Biol Chem 284:2811-22. 2009
    ..Our results indicate that lactate suppresses lipolysis in adipose tissue through a direct activation of GPR81. GPR81 may thus be an attractive target for the treatment of dyslipidemia and other metabolic disorders...
  21. pmc A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation
    Bo Thomsen
    Department of Genetics and Biotechnology, Danish Institute of Agricultural Sciences, DK 8830 Tjele, Denmark
    Genome Res 16:97-105. 2006
    The extensive use of a limited number of elite bulls in cattle breeding can lead to rapid spread of recessively inherited disorders...
  22. pmc Domain structure of a mammalian myosin I beta
    O Reizes
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas 75235
    Proc Natl Acad Sci U S A 91:6349-53. 1994
    We have determined the primary structure of a myosin I (called mammalian myosin I beta, MMI beta) from bovine brain and identified its functional domains. The protein was previously purified from brain and adrenal gland...
  23. ncbi Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state
    T Tanaka
    Division of Molecular and Structural Biology, Ontario Cancer Institute, Toronto, Canada
    Nature 376:444-7. 1995
    ..The myristoyl group is sequestered in a deep hydrophobic pocket formed by many aromatic and other hydrophobic residues from five flanking helices...
  24. ncbi Closing the folding chamber of the eukaryotic chaperonin requires the transition state of ATP hydrolysis
    Anne S Meyer
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 113:369-81. 2003
    ..Understanding the distinct mechanisms governing eukaryotic and bacterial chaperonin function may reveal how TRiC has evolved to fold specific eukaryotic proteins...
  25. ncbi Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransduction
    W A Gorczyca
    Department of Ophthalmology, University of Washington, Seattle 98195
    J Biol Chem 270:22029-36. 1995
    ....
  26. doi Highly effective SNP-based association mapping and management of recessive defects in livestock
    Carole Charlier
    Unit of Animal Genomics, GIGA Research and Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège B34, 1 Avenue de l Hopital, 4000 Liege, Belgium
    Nat Genet 40:449-54. 2008
    ..We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle ..
  27. pmc Identification of core amino acids stabilizing rhodopsin
    A J Rader
    Center for Computational Biology and Bioinformatics, Department of Molecular Biology and Biochemistry, School of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 101:7246-51. 2004
    ..The observed high degree of conservation (78.9%) of this disulfide bond across all GPCR classes suggests that it is critical for the stability and function of GPCRs...
  28. pmc Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomes
    Anne Sophie Van Laere
    Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liege, Belgium
    Genome Res 18:1884-95. 2008
    ..Accordingly, we demonstrate that cattle share their PAB with all other examined ruminants including sheep, but not with cetaceans or more distantly ..
  29. ncbi Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    M Uehata
    Discovery Research Tokyo, Yoshitomi Pharmaceutical Industries Ltd, Saitama, Japan
    Nature 389:990-4. 1997
    ..Our findings indicate that p160ROCK-mediated Ca2+ sensitization is involved in the pathophysiology of hypertension and suggest that compounds that inhibit this process might be useful therapeutically...
  30. doi Molecular determinants of oocyte competence: potential functional role for maternal (oocyte-derived) follistatin in promoting bovine early embryogenesis
    Kyung Bon Lee
    Laboratory of Mammalian Reproductive Biology and Genomics, Department of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA
    Endocrinology 150:2463-71. 2009
    ..Herein, we used the bovine model to test the hypothesis that follistatin plays a functional role in regulation of early embryogenesis...
  31. doi Short communication: Effects of the progesterone receptor variants on fertility traits in cattle
    A M Driver
    Department of Dairy Science, University of Wisconsin Madison, Madison, WI 53706, USA
    J Dairy Sci 92:4082-5. 2009
    ..Currently, it is unknown what variants of the PGR gene are related to fertility traits in cattle. Identification of such variants would allow the implementation of marker-assisted selection in breeding schemes...
  32. ncbi Polymorphisms in the IGF1 gene and their effect on growth traits in Mexican beef cattle
    X F De la Rosa Reyna
    Instituto Politecnico Nacional, Centro de Biotecnología Genómica, Reynosa, Tamaulipas, Mexico
    Genet Mol Res 9:875-83. 2010
    ..in the promoter region (IGF1/SnaBI) has been reported to be associated with production traits in several cattle breeds...
  33. doi Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant?
    N Forde
    School of Agriculture, Food Science and Veterinary Medicine, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Biol Reprod 85:144-56. 2011
    This study sought to determine the earliest response of the bovine uterine endometrium to the presence of the conceptus at key developmental stages of early pregnancy...
  34. ncbi Calpain 1-titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril
    Fabrice Raynaud
    Cell Motility Laboratory, EPHE, UMR 5539, UM2, Montpellier, France
    FEBS J 272:2578-90. 2005
    ..Furthermore, calpain 1 is found to localize in myofibril fractures, described as proteolysis sites, in postmortem bovine skeletal red muscles, near the calcium deposits located at the N1 and N2 level...
  35. ncbi Polymorphism in genes of growth hormone receptor (GHR) and insulin-like growth factor-1 (IGF1) and its association with both the IGF1 expression in liver and its level in blood in Polish Holstein-Friesian cattle
    Andrzej Maj
    Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05 552 Wolka Kosowska, Poland
    Neuro Endocrinol Lett 29:981-9. 2008
    ..Ghr and igf1 genes have been associated with milk and meat production of cattle. However, the molecular and physiological mechanisms underlying such associations are unknown...
  36. ncbi AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress
    Yingjia Zhang
    Division of Biomedical Sciences, University of California, Riverside, CA 92521 0121, USA
    Arterioscler Thromb Vasc Biol 26:1281-7. 2006
    ..In this study, we investigate the regulation of the AMPK-eNOS pathway in vascular endothelial cells (ECs) by shear stress and the activation of aortic AMPK in a mouse model with a high level of voluntary running (High-Runner)...
  37. pmc Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle
    D E Shuster
    U S Department of Agriculture, Agricultural Research Service, Ames, IA
    Proc Natl Acad Sci U S A 89:9225-9. 1992
    ..The carrier frequency for the D128G allele among Holstein cattle in the United States is approximately 15% among bulls and 6% among cows...
  38. ncbi Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit
    Jie Zheng
    Howard Hughes Medical Institute, Seattle, WA 98195, USA
    Neuron 36:891-6. 2002
    ..We find, surprisingly, that the channel contains three CNGA1 subunits and only one CNGB1 subunit. These results have implications for CNG channel function in particular and assembly of membrane proteins in general...
  39. ncbi Cloning of the bovine prion-like Shadoo (SPRN) gene by comparative analysis of the predicted genomic locus
    Cristina Uboldi
    Department of Genetics and Microbiology A Buzzati Traverso, University of Pavia, Pavia, Italy
    Mamm Genome 17:1130-9. 2006
    ..We mapped SPRN in Bos taurus by comparative analysis of the locus and of the predicted flanking genes...
  40. doi Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-κB p65 and C/EBPβ in mammary epithelial cells
    Shuzhen Liu
    University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Mol Immunol 48:895-908. 2011
    ..in MEC the role of NF-κB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle. Abrogating NF-κB binding to that site by introduction of a single point mutation blocks promoter activity of ..
  41. ncbi Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils
    M E Selsted
    Department of Pathology, College of Medicine, University of California, Irvine 92717
    J Biol Chem 268:6641-8. 1993
    A new family of cysteine-rich antimicrobial peptides from bovine neutrophils was isolated and characterized...
  42. doi A small set of extra-embryonic genes defines a new landmark for bovine embryo staging
    Séverine A Degrelle
    INRA ENVA, UMR 1198 Biologie du Developpement et Reproduction, Domaine de Vilvert, Jouy en Josas, France
    Reproduction 141:79-89. 2011
    ..To this end, we have profiled bovine extra-embryonic tissues at peri-implantation stages, when gastrulation and early neurulation occur, and analysed ..
  43. ncbi Molecular evidence for a critical period in mural trophoblast development in bovine blastocysts
    Séverine A Degrelle
    UMR INRA ENVA CNRS Biologie du Développement et de la Reproduction, 78352 Jouy en Josas Cedex, France
    Dev Biol 288:448-60. 2005
    ..To provide information on the development of the trophoblast lineage in late-implanting bovine embryos, we combined the use of molecular markers defining embryonic and extra-embryonic lineages in the mouse ..
  44. pmc Ionotropic glutamate receptor AMPA 1 is associated with ovulation rate
    Mayumi Sugimoto
    National Livestock Breeding Center, Nishigo, Japan
    PLoS ONE 5:e13817. 2010
    ..Based on a genome-wide association study in Bos taurus, we found that ovulation rate is influenced by a variation in the N-terminal leucine/isoleucine/valine-binding ..
  45. doi Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genes
    A Wang
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    J Dairy Sci 92:2696-705. 2009
    ..energy, but also regulate rumen development, insulin and glucagon secretion, and other physiological processes in cattle and sheep. The mechanism underlying the regulatory effects of VFA is unknown...
  46. ncbi Complete genomic sequence of the bovine prion gene (PRNP) and polymorphism in its promoter region
    D Hills
    Division of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
    Anim Genet 32:231-2. 2001
  47. ncbi Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1
    Jun Cai
    School of Optometry and Vision Sciences, Cardiff University, UK
    J Biol Chem 281:3604-13. 2006
    ..This confirms the importance of PEDF and VEGFR-1 in the negative regulation of angiogenesis...
  48. pmc An unusual splice defect in the mitofusin 2 gene (MFN2) is associated with degenerative axonopathy in Tyrolean Grey cattle
    Cord Drogemuller
    Institute of Genetics, University of Bern, Bern, Switzerland
    PLoS ONE 6:e18931. 2011
    Tyrolean Grey cattle represent a local breed with a population size of ∼5000 registered cows. In 2003, a previously unknown neurological disorder was recognized in Tyrolean Grey cattle...
  49. ncbi Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK
    Peter F Mount
    Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia
    Atherosclerosis 200:28-36. 2008
    ..test the hypothesis that bradykinin (BK) regulates AMPK and fatty acid oxidation in endothelium, stimulations of bovine aortic endothelial cells (BAECs) with bradykinin were performed. BK stimulation caused a 2...
  50. pmc Bovine insulin filaments induced by reducing disulfide bonds show a different morphology, secondary structure, and cell toxicity from intact insulin amyloid fibrils
    Tamotsu Zako
    Bioengineering Laboratory, RIKEN Institute, Saitama, Japan
    Biophys J 96:3331-40. 2009
    ..We demonstrate here that bovine insulin forms flexible filaments in the presence of a reducing agent, Tris (2-carboxyethyl) phosphine...
  51. doi Indels within promoter and intron 1 of bovine prion protein gene modulate the gene expression levels in the medulla oblongata of two Japanese cattle breeds
    G Msalya
    Kagoshima University, Japan
    Anim Genet 41:218-21. 2010
    ..In cattle, however, none of the known coding polymorphisms has a direct effect on bovine spongiform encephalopathy (BSE)...
  52. pmc Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus, Bos indicus, and composite cattle
    Brian W Brunelle
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010 USA
    BMC Vet Res 4:36. 2008
    ..These factors have been extensively studied in breeds of Bos taurus cattle in relation to classical bovine spongiform encephalopathy (BSE)...
  53. pmc How the regulatory protein, IF(1), inhibits F(1)-ATPase from bovine mitochondria
    Jonathan R Gledhill
    Medical Research Council Dunn Human Nutrition Unit, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 104:15671-6. 2007
    The structure of bovine F(1)-ATPase inhibited by a monomeric form of the inhibitor protein, IF(1), known as I1-60His, lacking most of the dimerization region, has been determined at 2.1-A resolution...
  54. doi Metabolomic profiles indicate distinct physiological pathways affected by two loci with major divergent effect on Bos taurus growth and lipid deposition
    Rosemarie Weikard
    Research Unit Molecular Biology, Leibniz Institute for Farm Animal Biology FBN, Dummerstorf, Germany
    Physiol Genomics 42:79-88. 2010
    ..in the growth differentiation factor 8 (GDF8) gene as substantial modulators of pre- and/or postnatal growth in cattle. In a combined metabolomic and genotype association approach, which is the first respective study in livestock, we ..
  55. pmc Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese black cattle
    Shogo Hoashi
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Nada, Kobe, Japan
    BMC Genet 9:84. 2008
    ....
  56. doi Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle
    Jyothsna Tejomurtula
    Division of Animal and Nutritional Sciences, Laboratory of Animal Biotechnology and Genomics, West Virginia University, Morgantown, West Virginia 26506, USA
    Biol Reprod 81:333-42. 2009
    ..Through analysis of expressed sequence tags from a bovine oocyte cDNA library, we identified a new member of the importin alpha family (named importin alpha8)...
  57. ncbi Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel
    U B Kaupp
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    Nature 342:762-6. 1989
    The complete amino-acid sequence of the cyclic GMP-gated channel from bovine retinal rod photoreceptors, deduced by cloning and sequencing its complementary DNA, shows that the protein contains several putative transmembrane segments, ..
  58. doi Novel mutations of the FASN gene and their effect on fatty acid composition in Japanese Black beef
    Tsuyoshi Abe
    National Livestock Breeding Center, 1 Odakurahara, Nishigo, Fukushima, Japan
    Biochem Genet 47:397-411. 2009
    ..coding sequence of the bovine fatty acid synthase (FASN) gene of an F2 population from Japanese Black and Limousin cattle. Two mutations, g.16024A>G and g...
  59. doi AluI polymorphism of the bovine growth hormone (GH) gene, resumption of ovarian cyclicity, milk production and loss of body condition at the onset of lactation in dairy cows
    O Balogh
    Faculty of Veterinary Science, Szent Istvan University, 1078 Budapest István u 2, Hungary
    Theriogenology 71:553-9. 2009
    ..We concluded that, under field conditions, AluI polymorphism of the bovine GH gene had no effect on the interval from calving to first ovulation and could not be directly related to ..
  60. ncbi IGF2 gene characterization and association with rib eye area in beef cattle
    J J Goodall
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, SK S7N 5A8, Canada
    Anim Genet 38:154-61. 2007
    ..factor 2 (IGF2) is an imprinted gene expressed in most tissues affecting lean muscle content in mice, pigs and cattle. We previously identified the bovine IGF2 c.-292C>T SNP in the non-translated exon 2...
  61. doi Molecular characterization of the DDX3Y gene and its homologs in cattle
    W S Liu
    Department of Dairy and Animal Science, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Cytogenet Genome Res 126:318-28. 2009
    ..Here, we report the characterization of the bovine (b) DDX3Y gene and its homologs DDX3X and PL10...
  62. doi The major protein of bovine seminal plasma, PDC-109, is a molecular chaperone
    Rajeshwer Singh Sankhala
    School of Chemistry, University of Hyderabad, Hyderabad 500046, India
    Biochemistry 49:3908-18. 2010
    The major protein of bovine seminal plasma, PDC-109, binds to choline phospholipids on the sperm plasma membrane and induces the efflux of cholesterol and choline phospholipids, which is an important step in sperm capacitation...
  63. doi Effect of VEGF (vascular endothelial growth factor) on expression of IL-8 (interleukin-8), IL-1beta and their receptors in bovine theca cells
    Chiaki Murayama
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Cell Biol Int 34:531-6. 2010
    ..receptors, CXCR1 and IL-1R1 in the theca cells of PRF (preselection) and POF (postselection follicles) from the bovine ovary...
  64. doi Interaction of mammalian seminal plasma protein PDC-109 with cholesterol: implications for a putative CRAC domain
    Silvia Scolari
    Department of Biology, Humboldt University Berlin, Invalidenstrasse 42, 10115 Berlin, Germany
    Biochemistry 49:9027-31. 2010
    ..To characterize the interaction between the bovine Fn2 protein PDC-109 and cholesterol, we have investigated the effect of PDC-109 on the dynamics of fluorescent ..
  65. ncbi Organization and concerted evolution of the ampliconic Y-chromosomal TSPY genes from cattle
    Edward L C Verkaar
    Faculty of Veterinary Medicine, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Genomics 84:468-74. 2004
    ..The homology of TSPY and the major Y-chromosomal repetitive elements BRY.2 from cattle and OY...
  66. ncbi Genomic structure and transcript variants of the bovine DAZL gene
    W S Liu
    Department of Animal Biotechnology, College of Agriculture, Biotechnology and Natural Resources, University of Nevada, Reno, NV 89557, USA
    Cytogenet Genome Res 116:65-71. 2007
    ..Our results lay the groundwork for possible single nucleotide polymorphism (SNP) and functional studies of the DAZL gene in cattle.
  67. ncbi Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcripts
    U Wissenbach
    Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, Homburg Saar, Germany
    FEBS Lett 429:61-6. 1998
    ..Complementary DNA was isolated from a bovine testis cDNA library which encodes bovine trp2 (btrp2), a protein of 432 amino acid residues comprising four ..
  68. pmc Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease
    Sujuan Xu
    Center for Advanced Biotechnology and Medicine, Department of Biochemistry, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 282:23525-31. 2007
    ..Here we report the crystal structure of bovine NPC2 bound to cholesterol-3-O-sulfate, an analog that binds with greater apparent affinity than cholesterol...
  69. ncbi Two-stage autolysis of the catalytic subunit initiates activation of calpain I
    U J Zimmerman
    Institute for Environmental Medicine, University of Pennsylvania Medical School, Philadelphia 19104
    Biochim Biophys Acta 1078:192-8. 1991
    Calcium-induced autolysis of bovine erythrocyte calpain I occurs in multiple stages. Initially, a 14 amino acid segment is cleaved from the N-terminus of the native 80 kDa catalytic subunit, yielding a 78 kDa form of the subunit...
  70. doi Tyrosine phosphorylation of scavenger receptor cysteine-rich WC1 is required for the WC1-mediated potentiation of TCR-induced T-cell proliferation
    Fei Wang
    Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA, USA
    Eur J Immunol 39:254-66. 2009
    ..In this study, we found that WC1 was constitutively phosphorylated in ex vivo bovine gammadelta T cells and associated with src family tyrosine kinases...
  71. ncbi Pattern of expression of the uterine milk protein gene and its association with productive life in dairy cattle
    H Khatib
    Department of Dairy Science, University of Wisconsin, Madison 53706, USA
    J Dairy Sci 90:2427-33. 2007
    ..of previous studies on the association of the UTMP region with milk production and productive life in dairy cattle. Expression of UTMP was examined in 198 bovine tissues obtained from 10 fetuses and 17 cows...
  72. ncbi Localized cdc42 activation, detected using a novel assay, mediates microtubule organizing center positioning in endothelial cells in response to fluid shear stress
    Eleni Tzima
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 278:31020-3. 2003
    ..Thus, shear-stimulated integrin dynamics induce polarized Cdc42 activity, which induces MTOC localization through the Par6-protein kinase Czeta complex...
  73. ncbi Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons
    B Ullrich
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical School, Dallas 75235
    Neuron 14:497-507. 1995
    ..Characterization of many independent bovine neurexin I alpha cDNAs suggests that different splice sites are used independently...
  74. ncbi Bacterial lipopolysaccharide induces increased expression of toll-like receptor (TLR) 4 and downstream TLR signaling molecules in bovine mammary epithelial cells
    Eveline M Ibeagha-Awemu
    Department of Animal Science, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, Quebec, H9X 3V9 Canada
    Vet Res 39:11. 2008
    b>Bovine mammary epithelial cells contribute to the innate immune response to intramammary infections by recognizing pathogens through specialized pattern recognition receptors...
  75. ncbi Pluripotent lineage definition in bovine embryos by Oct4 transcript localization
    Satoshi Kurosaka
    Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Biol Reprod 71:1578-82. 2004
    ..Despite highly conserved genomic organization and regulatory regions between the mouse Oct4 gene and its bovine orthologue, bovine Oct4 protein is not restricted to the inner cell mass of blastocyst-stage embryos, suggesting ..
  76. pmc Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere
    K F Sullivan
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037
    J Cell Biol 127:581-92. 1994
    ..These data clearly indicate that the assembly of centromeres is driven, at least in part, by the incorporation of a novel core histone into centromeric chromatin...
  77. ncbi Bovine SNRPN methylation imprint in oocytes and day 17 in vitro-produced and somatic cell nuclear transfer embryos
    Diana Lucifero
    McGill University and Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Biol Reprod 75:531-8. 2006
    ..we showed that the SNRPN methylation profiles previously observed in mouse and human studies are also conserved in cattle. Moreover, SCNT-derived Day 17 elongating embryos were abnormally hypomethylated compared with in vivo-produced ..
  78. ncbi Cofactor A is a molecular chaperone required for beta-tubulin folding: functional and structural characterization
    R Melki
    Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Biochemistry 35:10422-35. 1996
    ..Our data imply that cofactor A is a chaperone involved in tubulin folding...
  79. ncbi Crystal structure of the adenylyl cyclase activator Gsalpha
    R K Sunahara
    Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9041, USA
    Science 278:1943-7. 1997
    ....
  80. ncbi An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometrium
    Eric Madore
    Unité de Recherche en Ontogénie et Reproduction et Département d Obstétrique et Gynécologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Sainte Foy, Quebec G1V 4G2, Canada
    J Biol Chem 278:11205-12. 2003
    ..Taken together, these data point to this newly identified enzyme as the functional endometrial PGFS...
  81. pmc A novel cochaperonin that modulates the ATPase activity of cytoplasmic chaperonin
    Y Gao
    Department of Biochemistry, New York University Medical Center, New York 10016
    J Cell Biol 125:989-96. 1994
    ..Moreover, while GroES functions as a heptameric ring, cofactor A behaves as a dimer. Thus, cofactor A is a novel cochaperonin that is structurally unrelated to GroES...
  82. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  83. ncbi R120G alphaB-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable
    Teresa M Treweek
    Department of Chemistry, University of Wollongong, NSW, Australia
    FEBS J 272:711-24. 2005
    ..These characteristics may explain the involvement of R120G alphaB-crystallin with human disease states...
  84. ncbi Assignment of SRY, ANT3, and CSF2RA to the bovine Y chromosome by FISH and RH mapping
    Wan Sheng Liu
    Department of Animal Biotechnology, College of Agriculture, Biotechnology, and Natural Resources, University of Nevada, Reno, Nevada 89557, USA
    Anim Biotechnol 15:103-9. 2004
    ..RH mapping with a 7000-rad cattle hamster whole-genome radiation hybrid panel further defined the ANT3 and CSF2RA position in relationship to ..
  85. pmc Bovine CD14 gene characterization and relationship between polymorphisms and surface expression on monocytes and polymorphonuclear neutrophils
    Eveline M Ibeagha-Awemu
    Department of Animal Science, McGill University, Ste Anne de Bellevue, Quebec H9X 3V9, Canada
    BMC Genet 9:50. 2008
    ..The study was aimed at characterizing the CD14 gene of cattle for sequence variations and to determine the effect of variations on the expression of the protein on the surfaces ..
  86. ncbi PDC-109 (BSP-A1/A2) promotes bull sperm binding to oviductal epithelium in vitro and may be involved in forming the oviductal sperm reservoir
    TanYa M Gwathmey
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Biol Reprod 69:809-15. 2003
    Sperm reservoirs have been found in the oviducts of several species of mammals. In cattle, the reservoir is formed by the binding of sperm to fucose-containing glycoconjugates on the surface of oviductal epithelial cells...
  87. ncbi Molecular cloning and expression analysis of bovine programmed death-1
    Ryoyo Ikebuchi
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Microbiol Immunol 54:291-8. 2010
    ..this study, we performed identification and preliminary characterization of the bovine PD-1 gene in two breeds of cattle. We cloned full cDNA sequences encoding for PD-1 from both Holstein-Friesian and Japanese Black breeds, and found ..
  88. ncbi Involvement of pro-inflammatory cytokines, mediators of inflammation, and basic fibroblast growth factor in prostaglandin F2alpha-induced luteolysis in bovine corpus luteum
    T P Neuvians
    Department of Physiology, Technical University Munich, Weihenstephaner Berg 3, D 85350 Freising Weihenstephan, Germany
    Biol Reprod 70:473-80. 2004
    ..Immune cells and cytokines were shown to be relevant for bovine luteolysis...
  89. ncbi Bovine seminal plasma proteins PDC-109, BSP-A3, and BSP-30-kDa share functional roles in storing sperm in the oviduct
    TanYa M Gwathmey
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Biol Reprod 75:501-7. 2006
    ..In the bull, these proteins consist predominantly of the bovine seminal plasma family of proteins (BSPs): PDC-109 (BSP-A1/-A2), BSP-A3, and BSP-30-kDa...
  90. ncbi Fibroblast growth factor-2 is expressed by the bovine uterus and stimulates interferon-tau production in bovine trophectoderm
    Donna D Michael
    Department of Dairy and Animal Sciences, The Pennsylvania State University, University Park, 16802, USA
    Endocrinology 147:3571-9. 2006
    ..determine whether fibroblast growth factor-2 (FGF-2) is expressed in the bovine uterus during early pregnancy in cattle and to determine whether FGF-2 supplementation affects IFNT mRNA and protein abundance in bovine trophectoderm...
  91. pmc Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition
    Bernard Grisart
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 20 Boulevard de Colonster, 4000 Liege Sart Tilman, Belgium
    Proc Natl Acad Sci U S A 101:2398-403. 2004
    ..used a positional cloning approach to identify a nonconservative lysine to alanine substitution (K232A) in the bovine DGAT1 gene that was proposed to be the causative quantitative trait nucleotide underlying a quantitative trait ..
  92. doi Expression of pluripotency-related genes during bovine inner cell mass explant culture
    Disha Pant
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    Cloning Stem Cells 11:355-65. 2009
    ..In this study we monitored the expression of pluripotency-related genes in bovine inner cell mass (ICM) explants during the critical first steps in establishment of primary cultures...
  93. pmc Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein
    Yucheng Yao
    Division of Cardiology, David Geffen School of Medicine at UCLA, Box 951679, Los Angeles, CA 90095 1679, USA
    Circ Res 105:575-84. 2009
    ..Matrix Gla protein (MGP) is a calcification inhibitor, which binds and inhibits bone morphogenetic protein (BMP)-2 and -4...
  94. ncbi Molecular cloning and characterization of NESP55, a novel chromogranin-like precursor of a peptide with 5-HT1B receptor antagonist activity
    R Ischia
    Department of Pharmacology, University of Innsbruck, A 6020 Innsbruck, Austria
    J Biol Chem 272:11657-62. 1997
    ..Several NESP55 cDNA clones were isolated from bovine chromaffin cell libraries. The cDNA sequence of NESP55 totals 1499 nucleotides...
  95. ncbi Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein
    F Wopfner
    Genecenter, Department of Virology, Max von Pettenkofer Institute for Medical Microbiology, Ludwig Maximilians University of Munich, Feodor Lynen Str 25, Munich, 81377, Germany
    J Mol Biol 289:1163-78. 1999
    ..g. the N-terminal region from amino acid residue 23-90 and the regions located upstream of alpha-helices 1 and 3...
  96. ncbi Structure of the alpha beta tubulin dimer by electron crystallography
    E Nogales
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 391:199-203. 1998
    ....
  97. ncbi SNAP receptors implicated in vesicle targeting and fusion
    T Sollner
    Rockefeller Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Nature 362:318-24. 1993
    ..based on the natural binding of these proteins to their targets was used to isolate SNAP receptors (SNAREs) from bovine brain...
  98. ncbi Three-dimensional structure of recoverin, a calcium sensor in vision
    K M Flaherty
    Beckman Laboratories for Structural Biology, Department of Cell Biology, Stanford University School of Medicine, California 94305
    Cell 75:709-16. 1993
    ..The other two EF hands have novel structural features that prevent or impair calcium binding. A concave hydrophobic surface formed by EF hands 1 and 2 may participate in the read out of calcium signals by recoverin and its homologs...
  99. pmc Characterization and expression analysis of SOLD1, a novel member of the retrotransposon-derived Ly-6 superfamily, in bovine placental villi
    Koichi Ushizawa
    Reproductive Biology Research Unit, Division of Animal Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    PLoS ONE 4:e5814. 2009
    ..These members are divided into membrane-type and secretory-type proteins. In the present study, we report the identification of a novel Ly-6 domain protein, secreted protein of Ly-6 domain 1 (SOLD1), from bovine placenta.

Research Grants185 found, 100 shown here

  1. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Christopher Davies; Fiscal Year: 2009
    ..The incidence of immune-mediated abortion and placental insufficiency in both humans and cattle are greatly increased with the use of assisted reproductive technologies such as in vitro fertilization...
  2. Novel High Affinity and Long-Acting Bovine FSH Analogs for Veterinary Superovulat
    BRUCE DALE WEINTRAUB; Fiscal Year: 2012
    ..in CHO-DG44 cells in preparation for Phase 2 large-scale production, purification and superovulation studies in cattle. This completely novel recombinant bFSH analog protected by international patents until 2032 &without a known ..
  3. Tuberculosis epidemiology and novel transmission routes in rural Tanzania
    PHILIP C contact HOPEWELL; Fiscal Year: 2010
    ..livestock keepers (pastoralists) combined with poor public health infrastructure, limited TB control measures for cattle and animal products, and a large immunocompromised human population due to HIV/AIDS, make Africa particularly ..
  4. Tuberculosis epidemiology and novel transmission routes in rural Tanzania
    Philip C Hopewell; Fiscal Year: 2013
    ..livestock keepers (pastoralists) combined with poor public health infrastructure, limited TB control measures for cattle and animal products, and a large immunocompromised human population due to HIV/AIDS, make Africa particularly ..
  5. Method validation and comparison for the detection of mycotoxins in novel animal
    Lisa Murphy; Fiscal Year: 2013
    ..If the Charm ROSA-M readers can be validated for the analysis of dog food, cattle feed, and swine feed, they will provide an easy method for minimally-trained personnel at multiple laboratories to ..
  6. Missouri Food Safety Council Initiative
    LINDA HICKAM; Fiscal Year: 2013
    ..Missouri's agricultural diversity includes 107,825 farms, 3 million swine, over 3 million cattle, 4,448 egg retailers, 764 egg dealers, 8 processors, as well as 1,445 total permitted and licensed dairy farms, ..
  7. Antibody-Biocide Fusions to Control Cryptosporidium
    Michael Imboden; Fiscal Year: 2010
    ..C. parvum is zoonotic, with a reservoir in cattle, where it is an economically important cause of disease. There is currently no specific drug for cryptosporidiosis...
  8. MARKERS OF HUMAN INFECTION WITH BOVINE LEUKEMIA VIRUS
    GERTRUDE BUEHRING; Fiscal Year: 2006
    ..Bovine leukemia virus (BLV), an oncogenic retrovirus, causes widespread infection of cattle globally...
  9. MARKERS OF HUMAN INFECTION WITH BOVINE LEUKEMIA VIRUS
    GERTRUDE BUEHRING; Fiscal Year: 2007
    ..Bovine leukemia virus (BLV), an oncogenic retrovirus, causes widespread infection of cattle globally...
  10. Investigation of Occupational Exposure to and Infection by MRSA in Rural Iowa
    Tara Smith; Fiscal Year: 2010
    ..We will examine 30 farms during this research, including farms with live swine, cattle, and poultry. In the second part of our research plan, we will examine transmission of S...
  11. ANALYSIS OF TRYPANOSOME MRNA SYNTHESIS BY GENE TRANSFER
    Vivian Bellofatto; Fiscal Year: 2010
    ..In Africa, Trypanosoma brucei ssp. infect humans and domestic cattle, causing African sleeping sickness and Nagana, respectively. Human infection by the subspecies T. b...
  12. Characterize functions of T. brucei RAP1 and TRF in antigenic variation and telom
    Bibo Li; Fiscal Year: 2013
    ..applicant): Trypanosoma brucei is a protozoan parasite that causes African trypanosomiasis in humans and nagana in cattle. In mammalian hosts, bloodstream form (BF) T...
  13. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2010
    ..The incidence of immune-mediated abortion and placental insufficiency in both humans and cattle are greatly increased with the use of assisted reproductive technologies such as in vitro fertilization...
  14. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2010
    ..Importantly, protective immunity against Ov larvae has now been definitively demonstrated in humans, cattle and mice, thereby proving the conceptual underpinnings that a vaccine can be produced against this infection...
  15. Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigen
    Ana M Espino; Fiscal Year: 2013
    ..hepatica causes liver fluke disease or fascioliasis, thereby affecting the health of humans, as well as sheep, cattle and goats, among others mammalians. Fascioliasis causes losses in agriculture estimated at >US3...
  16. Mechanisms of Resistance and Susceptibility to African Trypanosome Infection
    Stephen L Hajduk; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Trypanosoma brucei brucei causes Nagana in cattle but is non-infectious to humans because of its susceptibility to the cytotoxic activity of normal human serum...
  17. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng George Wang; Fiscal Year: 2012
    ..coli fermentation. Such a bioconjugate already offers good possibility to be used to induce antibodies in cows or cattle to kill an inoculum of E. coli O157, since the vaccines can be produced in large scale economically...
  18. The Lysosome of Trypanosoma brucei: A Proteomic Analysis
    James D Bangs; Fiscal Year: 2011
    ..are parasitic protozoa that cause human African trypanosomiasis (HAT, sleeping sickness), as well as nagana in cattle and other livestock...
  19. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2013
    ..Importantly, protective immunity against Ov larvae has now been definitively demonstrated in humans, cattle and mice, thereby proving the conceptual underpinnings that a vaccine can be produced against this infection...
  20. Role of Fetal Steroids in Formation and Activation of Bovine Ovarian Follicles
    Joanne E Fortune; Fiscal Year: 2010
    ..In cattle, sheep, and other large mammals, including humans, primordial follicles form over a number of weeks during fetal ..
  21. Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrhea
    Linda J Saif; Fiscal Year: 2010
    ..of state-of-the-art technology for diagnosis (assays, reagents) and treatments (vaccines) for RV infections of cattle, the major agricultural commodity in Argentina...
  22. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng George Wang; Fiscal Year: 2013
    ..coli fermentation. Such a bioconjugate already offers good possibility to be used to induce antibodies in cows or cattle to kill an inoculum of E. coli O157, since the vaccines can be produced in large scale economically...
  23. SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTING
    Shinichiro Kurosawa; Fiscal Year: 2010
    ..There are certain strains of dangerous E. coli bacteria that can infect crops or cattle, and can be transmitted through our food distribution system to thousands of households...
  24. Mechanisms of Resistance and Susceptibility to African Trypanosome Infection
    Stephen L Hajduk; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma brucei brucei causes Nagana in cattle but is non-infectious to humans because of its susceptibility to the cytotoxic activity of normal human serum...
  25. EVC2: A novel modulator in tooth development
    Yoshiyuki Mochida; Fiscal Year: 2010
    ..A causative gene, LIMBIN for bovine chondrodysplastic dwarfism (bcd) found in Japanese brown cattle was later identified as the bovine ortholog of EVC2, indicating the significance of EVC2 protein function...
  26. EVC2: A novel modulator in tooth development
    Yoshiyuki Mochida; Fiscal Year: 2009
    ..A causative gene, LIMBIN for bovine chondrodysplastic dwarfism (bcd) found in Japanese brown cattle was later identified as the bovine ortholog of EVC2, indicating the significance of EVC2 protein function...
  27. Immunogenicity of the Type IV Secretin System
    WENDY CATHERINE BROWN; Fiscal Year: 2010
    ..By testing cattle that express a diverse repertoire of class II haplotypes, representative of the diversity of MHC class II ..
  28. A Phase I Study to Evaluate the Safety and Immunogenicity of HPV 16 L2 11-200
    WARNER KING HUH; Fiscal Year: 2010
    ..Vaccination of cattle with bovine papillomavirus type 4 (BPV4) L2 11-200 protects against BPV4 challenge on the soft palate...
  29. Impact of Microparticles on Oral TSE Infections
    Joel A Pedersen; Fiscal Year: 2010
    ..Microparticles are found in many other substances than soil. Meat and bone meal (MBM), a commonly used cattle food supplement thought responsible for BSE in Europe...
  30. Development of a Novel Rift Valley Fever Virus Vaccine
    Shinji Makino; Fiscal Year: 2013
    ..disease of sub-Saharan Africa that can emerge in explosive mosquito-borne epidemics, decimating herds of sheep and cattle and resulting in enormous economic losses;humans are infected concurrently, and their infection results in ..
  31. Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
    Anthony E Kincaid; Fiscal Year: 2010
    ..The results of this study will have implications for understanding the pathogenesis of other prion diseases such as bovine spongiform encephalopathy in cattle (mad cow disease) and variant Creutzfeldt-Jakob disease in humans.
  32. Point-of-Care Diagnostic Assay for Direct Detection of Pathogenic Leptospira
    Jeffrey Smith; Fiscal Year: 2010
    ..The World Health Organization lists the groups of people at risk of the infection ranging from cattle and pig farmers to veterinarians, butchers and slaughterhouse workers to children playing in rain puddles or mud, ..
  33. Structure and assembly of the fungal prion HET-s
    William N Wan; Fiscal Year: 2013
    ..TSEs include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer and elk, and several forms of Creutzfeldt-Jakob disease (CJD) in humans...
  34. Liposome-siRNA-Peptide Complexes as Therapy to Cure Prion Diseases in Mouse Model
    Mark D Zabel; Fiscal Year: 2013
    ..spongiform encephalopathies (TSEs) include scrapie in sheep;bovine spongiform encephalopathy (BSE) in cattle;chronic wasting disease (CWD) in deer and elk;and Kuru and Creutzfeldt-Jakob disease in humans...
  35. REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEI
    CHING CHUNG WANG; Fiscal Year: 2011
    ..are the causative pathogens of African sleeping sickness in humans and nagana in cattle. They are a family of deeply branched eukaryotes that exhibit many unique features during their cell cycle ..
  36. 2009 Spirochetes, Biology of
    David A Haake; Fiscal Year: 2010
    ..including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been very difficult to study...
  37. Lysosomal biogenesis and function in African trypanosomes
    James D Bangs; Fiscal Year: 2013
    ..are parasitic protozoa that cause human African trypanosomiasis (HAT, sleeping sickness), as well as nagana in cattle and other livestock...
  38. Lysosomal biogenesis and function in African trypanosomes
    James D Bangs; Fiscal Year: 2013
    ..are parasitic protozoa that cause human African trypanosomiasis (HAT, sleeping sickness), as well as nagana in cattle and other livestock...
  39. Epigenetic Modulation of PTPG by Zeranol in Beef Increases Breast Cancer Risk
    Young C Lin; Fiscal Year: 2010
    ..The overall HYPOTHESIS to be evaluated is that the consumption of beef products, derived from Z-implanted beef cattle may possess a potential health impact on human consumers, particularly with respect to reproductive endocrinology ..
  40. RNA METABOLISM IN TRYPANOSOMES
    Elisabetta Ullu; Fiscal Year: 2010
    ..agents of African trypanosomiasis or sleeping sickness in humans and a wasting and fatal disease (Nagana) in cattle, domestic pigs and other farm animals causing a profound effect on the economy of much of the continent...
  41. Epigenetic Modulation of PTPG by Zeranol in Beef Increases Breast Cancer Risk
    Young C Lin; Fiscal Year: 2010
    ..The overall HYPOTHESIS to be evaluated is that the consumption of beef products, derived from Z-implanted beef cattle may possess a potential health impact on human consumers, particularly with respect to reproductive endocrinology ..
  42. Regulation of osteoclast biology by anion exchanger SLC4A2 in mouse and human sys
    Antonios O Aliprantis; Fiscal Year: 2013
    ..A recent publication has identified a nearly identical phenotype in cattle that lack SLC4A2...
  43. EVC2: A novel modulator in tooth development
    Yoshiyuki Mochida; Fiscal Year: 2013
    ..A causative gene, LIMBIN for bovine chondrodysplastic dwarfism (bcd) found in Japanese brown cattle was later identified as the bovine ortholog of EVC2, indicating the significance of EVC2 protein function...
  44. One Health Innovation Fellowships for Zoonotic Disease Research In Mongolia
    GREGORY CHARLES GRAY; Fiscal Year: 2013
    ..Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle. Large segments of the normally nomadic pastoral populations have begun migrating to urban areas and introducing ..
  45. Parameters that govern initiation of VSG switching in T.brucei
    F Nina Papavasiliou; Fiscal Year: 2010
    ..The parasite Trypanosoma brucei is the causative agent of African sleeping sickness in humans and of Nagana in cattle, and one of the leading impediments to development in much of sub-Saharan Africa. T...
  46. Parameters that govern initiation of VSG switching in T.brucei
    F Nina Papavasiliou; Fiscal Year: 2013
    ..The parasite Trypanosoma brucei is the causative agent of African sleeping sickness in humans and of Nagana in cattle, and one of the leading impediments to development in much of sub-Saharan Africa. T...
  47. Pathogenesis, Transmission and Detection of Zoonotic Prion Diseases (P01)
    Claudio Soto; Fiscal Year: 2010
    ..Although rare, the recent outbreak of Bovine Spongiform Encephalopathy(BSE) in cattle and Chronic Wasting disease (CWD) in cervids and the transmission of the disease from cattle to humans have caused ..
  48. Environmental Health Specialist Network
    RICHARD NORMAN DANILA; Fiscal Year: 2013
    ..specific questions about well water and other exposures), and application of GIS using data sources such as cattle density, geologic sensitivity to groundwater contamination, and climate variables (e.g., flooding)...
  49. Mechanisms underlying myostatin regulation and activity
    Se Jin Lee; Fiscal Year: 2010
    ..Subsequent genetic studies in cattle, sheep, dogs, and humans have all shown that the function of myostatin as a negative regulator of muscle mass has ..
  50. REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEI
    Ching Wang; Fiscal Year: 2009
    ..are the causative pathogens of spp., African sleeping sickness in humans and nagana in cattle. They are a family of sickness in humans and nagana in cattle...
  51. Environmental Health Specialist Network
    RICHARD NORMAN DANILA; Fiscal Year: 2010
    ..specific questions about well water and other exposures), and application of GIS using data sources such as cattle density, geologic sensitivity to groundwater contamination, and climate variables (e.g., flooding)...
  52. A Novel Approach to RSV Vaccination
    Joan E Durbin; Fiscal Year: 2010
    ..In this proposal we will test this vaccine for safety and effectiveness in cotton rats and cattle, the animals who suffer a similar disease with this virus...
  53. A Novel Approach to RSV Vaccination
    Joan E Durbin; Fiscal Year: 2013
    ..In this proposal we will test this vaccine for safety and effectiveness in cotton rats and cattle, the animals who suffer a similar disease with this virus...
  54. Epigenetic control of preimplantation embryo development
    Pablo Juan Ross; Fiscal Year: 2013
    ..Early embryonic mortality is a major cause of infertility in dairy cattle and humans...
  55. Development of a Biochemical Diagnosis for Creutzfeldt-Jakob disease
    Claudio Soto; Fiscal Year: 2013
    ..disease (sCJD), the most common form, and variant CJD (vCJD) which is associated to consumption of cattle meat infected by bovine spongiform encephalopathy...
  56. Molecular Mechanisms of Prion and Amyloid Propagation
    Christopher P Jaroniec; Fiscal Year: 2013
    ..disorders that include Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Mammalian prions propagate by a mechanism involving the conformational conversion of a largely a-helical cellular ..
  57. RNA CAPPING IN TRYPANOSOMES
    Christian Tschudi; Fiscal Year: 2010
    ..agents of African trypanosomiasis or sleeping sickness in humans and a wasting and fatal disease (Nagana) in cattle, domestic pigs and other farm animals causing a profound effect on the economy of much of the continent...
  58. "Physical and Chemical Cues that Guide Sperm Migration"
    Mingming Wu; Fiscal Year: 2013
    ..Infertility affects about 7% of married couples in the US and the success rate of artificial insemination in the cattle industry has been dropping over the past several years...
  59. High Throughput Screening for Foot and Mouth Disease Virus Antivirals
    John F Atkins; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The infection of cattle with Foot and Mouth Disease Virus (FMDV) causes not only great economic damage but great popular panic, e.g...
  60. LYMPHOCYTE-MEDIATED IMMUNITY TO ANAPLASMA MARGINALE
    Reginald Valdez; Fiscal Year: 1999
    ..There was some uncertainty as to the extent of the problem of acute anaplasmosis infection in cattle and how the research findings might impact the field. Since Dr...
  61. Pathogenesis, Transmission and Detection of Zoonotic Prion Diseases (P01)
    Claudio Soto; Fiscal Year: 2009
    ..Although rare, the recent outbreak of Bovine Spongiform Encephalopathy(BSE) in cattle and Chronic Wasting disease (CWD) in cervids and the transmission of the disease from cattle to humans have caused ..
  62. Phosphoinositides in the T. brucei Endomembrane System
    Julia K Gilden; Fiscal Year: 2013
    ..protozoa responsible for causing human African trypanosomiasis (HAT, sleeping sickness) in humans and nagana in cattle and other livestock...
  63. Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrhea
    Linda Saif; Fiscal Year: 2009
    ..of state-of-the-art technology for diagnosis (assays, reagents) and treatments (vaccines) for RV infections of cattle, the major agricultural commodity in Argentina...
  64. REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEI
    CHING CHUNG WANG; Fiscal Year: 2010
    ..are the causative pathogens of African sleeping sickness in humans and nagana in cattle. They are a family of deeply branched eukaryotes that exhibit many unique features during their cell cycle ..
  65. MOLECULAR STUDIES OF HUMAN AND ANIMAL PRION PROTEINS
    Shu Chen; Fiscal Year: 2002
    ..due to the occurrence in young adults of a new variant form of CJD (vCJD) that is thought to originate rom BSE in cattle. The long-term objective of the present project is to understand the structural basis by which PrP-Sc modulates ..
  66. MOLECULAR STUDIES ON BIV AND BHV INTERACTIONS
    Charles Wood; Fiscal Year: 1993
    Bovine immunodeficiency-like virus (BIV) is a recently characterized lentivirus isolated from cattle. It is the only lentivirus which has been isolated from cattle and has structural, genetic, antigenic as well as biological similarity to ..
  67. Characterization of de novo generation of infectious prions
    Joaquin Castilla; Fiscal Year: 2009
    ..e. Bovine spongiform encephalopathy (BSE) in US cattle and Nor98 (atypical scrapie) in New Zealand sheep, provide evidence that this infrequent spontaneous phenomenon ..
  68. A Phase I Study to Evaluate the Safety and Immunogenicity of HPV 16 L2 11-200
    Warner Huh; Fiscal Year: 2009
    ..Vaccination of cattle with bovine papillomavirus type 4 (BPV4) L2 11-200 protects against BPV4 challenge on the soft palate...
  69. Characterization of prion protein conformational changes
    VALERIE D DAGGETT; Fiscal Year: 2010
    ..disease, fatal familial insomnia and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer and elk. While rare, these diseases are always fatal...
  70. Characterization of prion protein conformational changes
    Valerie Daggett; Fiscal Year: 2009
    ..disease, fatal familial insomnia and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer and elk. While rare, these diseases are always fatal...
  71. Characterization of prion protein conformational changes
    Valerie Daggett; Fiscal Year: 2007
    ..disease, fatal familial insomnia and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer and elk. While rare, these diseases are always fatal...
  72. THE ANTIVIRAL ACTIVITY OF E.COLI SHIGA TOXIN
    CAROLYN HOVDE; Fiscal Year: 2000
    ..STEC strains, both virulent and non-virulent to humans, inhabit the gastrointestinal tracts of most health cattle. Interestingly, despite intensive investigations, an explanation as to why cattle carry STEC has not surfaced...
  73. Key molecular mechanisms of extraneural pathogenesis and transmission of TSEs
    Mark D Zabel; Fiscal Year: 2010
    ..include chronic wasting disease (CWD) of deer and elk, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jacob disease and kuru in humans...
  74. Key molecular mechanisms of extraneural pathogenesis and transmission of TSEs
    Mark Zabel; Fiscal Year: 2009
    ..include chronic wasting disease (CWD) of deer and elk, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jacob disease and kuru in humans...
  75. REGULATION OF OVARIAN FOLLICULAR STEROID PRODUCTION
    JOANNE FORTUNE; Fiscal Year: 1992
    ..Oxytocin (OT) is produced by granulosa cells from humans and a number of other mammalian species, including cattle. Experiments conducted during the current grant period suggest that in cattle OT is involved in the mechanism by ..
  76. Role of Fetal Steroids in Formation and Activation of Bovine Ovarian Follicles
    JOANNE FORTUNE; Fiscal Year: 2009
    ..In cattle, sheep, and other large mammals, including humans, primordial follicles form over a number of weeks during fetal ..
  77. Cyclic Amplification of Prion Protein Misfolding
    Claudio Soto; Fiscal Year: 2010
    ..outbreak of Bovine Spongiform Encephalopathy and Chronic Wasting disease and the transmission of the disease from cattle to humans have risen a great public health concern...