sheep

Summary

Alias: domestic sheep, lambs, wild sheep, ovis aries, ovis ammon aries, ovis orientalis, ovis orientalis aries, ovis ovis

Top Publications

  1. ncbi Polymorphisms of the prion protein gene in sheep of Inner Mongolia, China
    Yiqin Wang
    National Animal Transmissible Spongiform Encephalopathies Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    Virus Genes 37:128-30. 2008
  2. ncbi Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells
    T Wilson
    AgResearch Molecular Biology Unit, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Biol Reprod 64:1225-35. 2001
  3. ncbi Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene
    W Goldmann
    Institute for Animal Health, AFRC and MRC Neuropathogenesis Unit, Edinburgh, U K
    J Gen Virol 72:2411-7. 1991
  4. ncbi Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development
    Feng Guan
    College of Life Sciences, China Jiliang University, Hangzhou 310018, Zhejiang Province, China
    Anim Reprod Sci 99:44-52. 2007
  5. ncbi Prion protein gene (PRNP) polymorphisms in Xinjiang local sheep breeds in China
    Z Lan
    Life Sciences and Technology College, Ocean University of China, Qingdao, P R China
    Arch Virol 151:2095-101. 2006
  6. ncbi Association of CD80 and CD86 expression levels with disease status of Visna/Maedi virus infected sheep
    Ramses Reina
    Instituto de Agrobiotecnología CSIC Universidad Pública de Navarra Gobierno de Navarra, Navarra
    Viral Immunol 20:609-22. 2007
  7. ncbi PrP (prion) gene expression in sheep may be modulated by alternative polyadenylation of its messenger RNA
    W Goldmann
    Neuropathogenesis Unit, BBSRC Institute for Animal Health, Edinburgh, UK
    J Gen Virol 80:2275-83. 1999
  8. ncbi Gene expression profiles of novel caprine placental prolactin-related proteins similar to bovine placental prolactin-related proteins
    Koichi Ushizawa
    Reproductive Biology Research Unit, Division of Animal Sciences, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, Ibaraki 305 8602, Japan
    BMC Dev Biol 7:16. 2007
  9. ncbi Topographic variation in biglycan and decorin synthesis by articular cartilage in the early stages of osteoarthritis: an experimental study in sheep
    C B Little
    Raymond Purves Bone and Joint Research Laboratories, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    J Orthop Res 14:433-44. 1996
  10. ncbi IFN-tau: a novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities
    J L Martal
    INRA, Station de Physiologie Animale, Unité Endocrinologie de l Embryon, Jouy en Josas, France
    Biochimie 80:755-77. 1998

Research Grants

Detail Information

Publications200 found, 100 shown here

  1. ncbi Polymorphisms of the prion protein gene in sheep of Inner Mongolia, China
    Yiqin Wang
    National Animal Transmissible Spongiform Encephalopathies Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    Virus Genes 37:128-30. 2008
    ..of the prion protein gene (Prnp), especially the amino acid residue alterations at codons 136, 154, and 174, in sheep have been found to be associated with susceptibility to scrapie disease...
  2. ncbi Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells
    T Wilson
    AgResearch Molecular Biology Unit, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Biol Reprod 64:1225-35. 2001
    The Booroola fecundity gene (FecB) increases ovulation rate and litter size in sheep and is inherited as a single autosomal locus. The effect of FecB is additive for ovulation rate (increasing by about 1...
  3. ncbi Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene
    W Goldmann
    Institute for Animal Health, AFRC and MRC Neuropathogenesis Unit, Edinburgh, U K
    J Gen Virol 72:2411-7. 1991
    The incubation period of scrapie in sheep is controlled by the Sip gene which has two alleles (sA and pA). Following experimental challenge with SSBP/1 scrapie, a short incubation period is conferred by the partially dominant sA allele...
  4. ncbi Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development
    Feng Guan
    College of Life Sciences, China Jiliang University, Hangzhou 310018, Zhejiang Province, China
    Anim Reprod Sci 99:44-52. 2007
    ..2 (+/-0.68) (P < 0.01). At 90 days after birth, the body weights of BB/B+ lambs were higher than that of ++ lambs (18.6 +/- 3.70 kg, 18.0 +/- 3.71 kg versus 15.6 +/- 2.22 kg, P < 0.05)...
  5. ncbi Prion protein gene (PRNP) polymorphisms in Xinjiang local sheep breeds in China
    Z Lan
    Life Sciences and Technology College, Ocean University of China, Qingdao, P R China
    Arch Virol 151:2095-101. 2006
    ..those occurring at codons 136, 154, and 171 have a significant influence on scrapie pathogenesis in many sheep breeds...
  6. ncbi Association of CD80 and CD86 expression levels with disease status of Visna/Maedi virus infected sheep
    Ramses Reina
    Instituto de Agrobiotecnología CSIC Universidad Pública de Navarra Gobierno de Navarra, Navarra
    Viral Immunol 20:609-22. 2007
    ..molecules B7-1 and B7-2 are involved in infections with Visna/Maedi virus (VMV), the prototype lentivirus of sheep. We studied B7 expression levels ex vivo in peripheral blood mononuclear cells (PBMCs), determining B7 RNA levels ..
  7. ncbi PrP (prion) gene expression in sheep may be modulated by alternative polyadenylation of its messenger RNA
    W Goldmann
    Neuropathogenesis Unit, BBSRC Institute for Animal Health, Edinburgh, UK
    J Gen Virol 80:2275-83. 1999
    ..expression in the hosts of these diseases, we have analysed some characteristics of PrP gene RNA transcripts in sheep and cattle tissues and made comparisons with PrP RNA transcripts in human and mouse tissues...
  8. ncbi Gene expression profiles of novel caprine placental prolactin-related proteins similar to bovine placental prolactin-related proteins
    Koichi Ushizawa
    Reproductive Biology Research Unit, Division of Animal Sciences, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, Ibaraki 305 8602, Japan
    BMC Dev Biol 7:16. 2007
    ..Caprine PRPs are compared with known bovine PRPs. We examined their evolution and role in the ruminant placenta...
  9. ncbi Topographic variation in biglycan and decorin synthesis by articular cartilage in the early stages of osteoarthritis: an experimental study in sheep
    C B Little
    Raymond Purves Bone and Joint Research Laboratories, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    J Orthop Res 14:433-44. 1996
    ..These data suggest that an altered chondrocyte phenotypic expression of proteoglycans in response to abnormal mechanical loading is an early event in osteoarthritis...
  10. ncbi IFN-tau: a novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities
    J L Martal
    INRA, Station de Physiologie Animale, Unité Endocrinologie de l Embryon, Jouy en Josas, France
    Biochimie 80:755-77. 1998
    ..It is believed to suppress pulsatile release of endometrial PGF-2alpha by preventing oxytocin and estrogen receptor expression. Additionally, it directly regulates prostaglandin metabolism and possibly the PGE:PGF-2alpha ratio...
  11. ncbi A single-base change in the tyrosine kinase II domain of ovine FGFR3 causes hereditary chondrodysplasia in sheep
    J E Beever
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801 4734, USA
    Anim Genet 37:66-71. 2006
    ..that is characterized by severe skeletal abnormalities and has resulted in substantial economic losses for sheep producers...
  12. ncbi Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins
    Stefán R Jónsson
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:5683-94. 2006
    ..Here, we report an APOBEC3F-like, double deaminase domain protein from three artiodactyls: cattle, pigs and sheep. Like their human counterparts, APOBEC3F and APOBEC3G, the artiodactyl APOBEC3F proteins are DNA cytosine ..
  13. ncbi Progesterone modulation of osteopontin gene expression in the ovine uterus
    G A Johnson
    Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Center, College Station, Texas 77843 2471, USA
    Biol Reprod 62:1315-21. 2000
    ....
  14. ncbi Identification of novel pregnancy-associated glycoproteins (PAG) expressed by the peri-implantation conceptus of domestic ruminants
    Juana M Garbayo
    Department of Animal Production, CITA, Zaragoza, Spain
    Anim Reprod Sci 103:120-34. 2008
    ..Interestingly, the three new early PAG identified in sheep and goats are clustered together within the PAG I group...
  15. ncbi Identification of a mutation in the ovine uroporphyrinogen decarboxylase (UROD) gene associated with a type of porphyria
    R Nezamzadeh
    Institute of Veterinary Medicine, University of Gottingen, Gottingen, Germany
    Anim Genet 36:297-302. 2005
    ..Although disorders of haeme biosynthesis have been described in cattle, pigs, sheep and cats, PCT has only been reported in pigs...
  16. ncbi Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype
    Erica Davis
    Department of Genetics, Faculty of Veterinary Medicine, University of Liege, B 43 Sart Tilman, Boulevard du Colonster 20, 4000 Liege, Belgium
    Curr Biol 14:1858-62. 2004
    The callipyge (CLPG) phenotype is an inherited skeletal muscle hypertrophy described in sheep. It is characterized by an unusual mode of inheritance ("polar overdominance") in which only heterozygous individuals having received ..
  17. ncbi Identification of a new leucine haplotype (ALQ) at codon 154 in the ovine prion protein gene in Spanish sheep
    L Alvarez
    Departamento de Producción Animal I, Universidad de Leon, 24071 Leon, Spain
    J Anim Sci 84:259-65. 2006
    ..In this paper, we describe the method used with 2 Spanish dairy sheep breeds (Churra and Castellana) to ascertain the initial status of protection against scrapie as a first step ..
  18. ncbi Postnatal changes in the expression of genes located in the callipyge region in sheep skeletal muscle
    A C Perkins
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    Anim Genet 37:535-42. 2006
    The expression of five genes surrounding the callipyge (CLPG) mutation was analysed in skeletal muscles from lambs at one prenatal and two postnatal ages that coincide with the onset and establishment of muscle hypertrophy...
  19. ncbi Control of interferon-tau gene expression by Ets-2
    T Ezashi
    Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 95:7882-7. 1998
    ..The presence of Ets-2 in nuclei of embryonic trophectoderm was confirmed immunocytochemically. Together, these data suggest that Ets-2 plays a role in the transient expression of the nonvirally inducible IFNT genes...
  20. ncbi Analysis of the callipyge phenotype through skeletal muscle development; association of Dlk1 with muscle precursor cells
    Jason D White
    School of Veterinary Science, The University of Melbourne, Parkville, VIC 3010, Australia
    Differentiation 76:283-98. 2008
    The callipyge mutation in sheep in the form of the paternal heterozygote results in skeletal muscle hypertrophy, which is most pronounced in the hindquarters...
  21. ncbi Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep
    Susan K Murphy
    Department of Radiation Oncology, Duke University, Box 3433, Durham, North Carolina 27710, USA
    Mamm Genome 16:171-83. 2005
    The underlying mechanism of the callipyge muscular hypertrophy phenotype in sheep (Ovis aries) is not presently understood...
  22. ncbi Identification of the major pregnancy-specific antigens of cattle and sheep as inactive members of the aspartic proteinase family
    S C Xie
    Department of Animal Sciences, University of Missouri, Columbia 65211
    Proc Natl Acad Sci U S A 88:10247-51. 1991
    Pregnancy in cattle and sheep can be diagnosed by the presence of a conceptus-derived antigen in maternal serum that is secreted by trophoblast and placental tissue primarily as an acidic component of Mr 67,000...
  23. ncbi Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8
    C Charlier
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 4000 Liege, Belgium
    Genome Res 11:850-62. 2001
    ..The six transcripts were also shown to be subject to parental imprinting: DLK1, DAT, and PEG11 were shown to be paternally expressed and GTL2, antiPEG11, and MEG8 to be maternally expressed...
  24. ncbi Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm
    K Imakawa
    Department of Animal Sciences, University of Missouri, Columbia 65211
    Nature 330:377-9. 1987
    ..The active substance implicated in signalling maternal recognition of pregnancy in the sheep is an embryonic secretory protein, known as ovine trophoblast protein-1 (oTP-1) (refs 2-4), which is targeted in a ..
  25. ncbi The major progesterone-modulated proteins secreted into the sheep uterus are members of the serpin superfamily of serine protease inhibitors
    N H Ing
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville 32610
    J Biol Chem 264:3372-9. 1989
    ..However, we have been unable to demonstrate inhibitory activity toward any serine protease so far tested...
  26. ncbi Strain-associated variations in abnormal PrP trafficking of sheep scrapie
    Martin Jeffrey
    Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, Edinburgh, UK
    Brain Pathol 19:1-11. 2009
    ..We show here that different light microscopic types of abnormal PrP (PrP(d)) accumulation found in each of 10 sheep scrapie cases correspond ultrastructurally with abnormal endocytosis, increased endo-lysosomes, microfolding of ..
  27. ncbi Cloning and expression of ovine placental lactogen
    P Colosi
    Department of Developmental Biology, Genentech, Inc, South San Francisco, California 94080
    Mol Endocrinol 3:1462-9. 1989
    ..Interestingly, the sequence of oPL differs from hGH at most of the amino acids recently found by mutagenesis studies to be important residues in the binding of hGH to the human receptor...
  28. ncbi The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status
    C Charlier
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, Liege, Belgium
    Nat Genet 27:367-9. 2001
    ..kappa(alpha)lambda(iota), "beautiful," and pi(iota)gamma(epsilon), "buttocks") described in sheep is an inherited muscular hypertrophy that is subject to an unusual parent-of-origin effect referred to as polar ..
  29. ncbi Two single nucleotide polymorphisms in the myostatin (GDF8) gene have significant association with muscle depth of commercial Charollais sheep
    G Hadjipavlou
    Roslin Institute and Royal Dick School of Veterinary Studies, Roslin Biocentre, Midlothian EH25 9PS, UK
    Anim Genet 39:346-53. 2008
    ..Mixed model association analyses using SNP data on 338 Charollais lambs from 17 paternal half-sib families and phenotype and pedigree data on 56 500 lambs revealed that both SNPs had a ..
  30. ncbi Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie
    D Westaway
    Department of Neurology, University of California, San Francisco 94143
    Genes Dev 8:959-69. 1994
    ..To address this conundrum, we determined the structure of the sheep prion protein (PrP) gene, which contains three exons and extends over 20 kb of DNA. In the United States 86...
  31. ncbi Expression and characterization of novel ovine orthologs of bovine placental prolactin-related proteins
    Koichi Ushizawa
    Reproductive Biology Research Unit, Division of Animal Sciences, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, Ibaraki 305 8602, Japan
    BMC Mol Biol 8:95. 2007
    ..We investigated placental PRP in sheep in order to gain a comprehensive understanding of the function and evolution of these molecules...
  32. ncbi Origin and evolution of the TKDP gene family
    Anindita Chakrabarty
    Department of Veterinary Pathobiology, University of Missouri Columbia, Columbia, MO 65211, USA
    Gene 373:35-43. 2006
    ..The TKDPs provide an example of a gene family that is evolving rapidly by whole gene duplication, intragenic duplication events, and selection for amino acid (aa) change...
  33. ncbi Muc-1, integrin, and osteopontin expression during the implantation cascade in sheep
    G A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Biol Reprod 65:820-8. 2001
    ..The potential involvement of OPN in the implantation adhesion cascade in sheep was investigated by examining temporal, spatial, and potential functional relationships between OPN, Muc-1, and ..
  34. ncbi The productive conformation of arachidonic acid bound to prostaglandin synthase
    M G Malkowski
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
    Science 289:1933-7. 2000
    ....
  35. ncbi Comparative genomic analysis of prion genes
    Marko Premzl
    Department of Molecular Biology, Rudjer Boskovic Institute, Zagreb, Croatia
    BMC Genomics 8:1. 2007
    ....
  36. ncbi PrP genotype contributes to determining survival times of sheep with natural scrapie
    A Bossers
    Department of Bacteriology, DLO Institute for Animal Science and Health, Lelystad, The Netherlands
    J Gen Virol 77:2669-73. 1996
    Several allelic variants of the sheep PrP gene are associated with scrapie susceptibility. However, it is not known whether, and to what extent, the PrP genotype contributes to determining survival times of scrapie sheep...
  37. ncbi Two alleles of a neural protein gene linked to scrapie in sheep
    W Goldmann
    Center for Molecular Biology, University of Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 87:2476-80. 1990
    b>Sheep are the natural hosts of the pathogens that cause scrapie, an infectious degenerative disease of the central nervous system...
  38. ncbi Stanniocalcin (STC) in the endometrial glands of the ovine uterus: regulation by progesterone and placental hormones
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 74:913-22. 2006
    ..The data suggest that STC1 secreted by the endometrial glands is transported into the fetal circulation and allantoic fluid, where it is hypothesized to regulate growth and differentiation of the fetus and placenta, by placental areolae...
  39. ncbi Ovine prion protein variant A(136)R(154)L(168)Q(171) increases resistance to experimental challenge with bovine spongiform encephalopathy agent
    Wilfred Goldmann
    Institute for Animal Health IAH, Neuropathogenesis Unit, West Mains Road, Edinburgh EH9 3JF, UK
    J Gen Virol 87:3741-5. 2006
    Susceptibility and incubation periods of transmissible spongiform encephalopathies, such as scrapie in sheep, are modulated by the PrP gene...
  40. ncbi The callipyge locus: evidence for the trans interaction of reciprocally imprinted genes
    Michel Georges
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 20 Bd de Colonster, 4000 Liege, Belgium
    Trends Genet 19:248-52. 2003
    The callipyge phenotype in sheep is an inherited muscular hypertrophy that affects only heterozygous individuals who receive the CLPG mutation from their father...
  41. ncbi Complete genomic sequence and analysis of the prion protein gene region from three mammalian species
    I Y Lee
    Department of Molecular Biotechnology, University of Washington, Seattle, Washington 98195 7730 USA
    Genome Res 8:1022-37. 1998
    ..organization of regions surrounding the PrP exons, we sequenced 10(5) bp of DNA from clones containing human, sheep, and mouse PrP genes isolated in cosmids or lambda phage...
  42. ncbi Ovine osteopontin: II. Osteopontin and alpha(v)beta(3) integrin expression in the uterus and conceptus during the periimplantation period
    G A Johnson
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843 2471, USA
    Biol Reprod 61:892-9. 1999
    ....
  43. ncbi Ovine osteopontin: I. Cloning and expression of messenger ribonucleic acid in the uterus during the periimplantation period
    G A Johnson
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843 2471, USA
    Biol Reprod 61:884-91. 1999
    ....
  44. ncbi PrP genotype in Sarda breed sheep and its relevance to scrapie. Brief report
    G Vaccari
    Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, Rome, Italy
    Arch Virol 146:2029-37. 2001
    Several PrP gene polymorphisms modulate sheep scrapie susceptibility. Recently, an increase of scrapie outbreaks has been reported in Italy. A vaccine containing sheep brain homogenate was used in most of the outbreaks...
  45. ncbi Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 69:92-8. 2003
    ..In sheep and humans, OPN is proposed to be a secretory product of uterine glandular epithelium (GE) that binds to uterine ..
  46. ncbi Characterization and expression of vascular endothelial growth factor (VEGF) in the ovine corpus luteum
    D A Redmer
    Department of Development and Signalling, Babraham Institute, Cambridge, UK
    J Reprod Fertil 108:157-65. 1996
    ....
  47. ncbi Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie
    P B Belt
    Department of Molecular Biology, DLO Institute for Animal Science and Health ID DLO, Lelystad, The Netherlands
    J Gen Virol 76:509-17. 1995
    Scrapie is a fatal neurodegenerative disease of sheep that belongs to the group of prion diseases found in humans and animals. The host encoded prion protein (PrP) plays a central role in the disease process...
  48. ncbi The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2
    Tim J Fitzmaurice
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
    Biochem J 409:367-75. 2008
    Susceptibility to scrapie disease in sheep, the archetypal prion disease, correlates with polymorphisms within the ovine PrP (prion-related protein) gene...
  49. ncbi Selective cloning of cDNA for secretory proteins of early embryos. Identification of a transiently expressed kunitz domain protein from preimplantation sheep trophoblast
    K K Kramer
    Department of Animal Sciences, University of Missouri, Columbia
    J Biol Chem 269:7255-61. 1994
    ..Despite their high expression, no proteinase-inhibitory activity can so far be ascribed to either the ovine or bovine proteins. The P1 residue, an asparagine, is not represented in any other known Kunitz inhibitors...
  50. ncbi Prion protein gene polymorphisms in healthy and scrapie-affected sheep in Greece
    Charalambos Billinis
    Laboratory of Microbiology and Infectious Diseases, Faculty of Veterinary Medicine, Aristotle University, GR 54124 Thessaloniki, Greece
    J Gen Virol 85:547-54. 2004
    A total of 216 local crossbred sheep from 16 scrapie-affected Greek flocks and 210 purebred sheep of the milk breeds Chios and Karagouniko from healthy flocks were analysed for scrapie-linked polymorphisms in the prion protein (PrP) gene...
  51. ncbi Globally dispersed Y chromosomal haplotypes in wild and domestic sheep
    J R S Meadows
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia 4067, Australia
    Anim Genet 37:444-53. 2006
    ..A-oY1 also had the highest frequency (71.4%) within 458 domestic sheep drawn from 65 breeds sampled from Africa, Asia, Australia, the Caribbean, Europe, the Middle East and Central ..
  52. ncbi Relationship between thoracic auscultation and lung pathology detected by ultrasonography in sheep
    Phil Scott
    Division of Veterinary Clinical Sciences, R D SVS, University of Edinburgh, Easter Bush, Roslin, Midlothian, Scotland EH25 9RG, UK
    Vet J 186:53-7. 2010
    ..auscultation to detect and characterise the nature of a range of superficial lung and pleural pathologies in domestic sheep was assessed using ultrasonographic examination to indicate and localise pathologies pre-mortem...
  53. ncbi Molecular cytogenetics and gene mapping in sheep (Ovis aries, 2n = 54)
    T Goldammer
    Forschungsbereich Molekularbiologie, Forschungsinstitut fur die Biologie landwirtschaftlicher Nutztiere FBN, Dummerstorf, Germany tomgoldammer fbn dummerstorf de
    Cytogenet Genome Res 126:63-76. 2009
    The development of a completely annotated sheep genome sequence is a key need for understanding the phylogenetic relationships and genetic diversity among the many different sheep breeds worldwide and for identifying genes controlling ..
  54. ncbi The effect of mixed or sequential grazing of cattle and sheep on the faecal egg counts and growth rates of weaned lambs when treated with anthelmintics
    C L Marley
    Plant, Animal and Microbial Science Department, Institute of Grassland and Environmental Research, Plas Gogerddan, Aberystwyth, Ceredigion SY23 3EB, UK
    Vet Parasitol 142:134-41. 2006
    ..clover) by cattle or sheep, either sequentially or mixed, on the faecal egg counts and growth rates of weaned lambs when treated with anthelmintics...
  55. ncbi Tissue residues of ractopamine and urinary excretion of ractopamine and metabolites in animals treated for 7 days with dietary ractopamine
    D J Smith
    USDA ARS, Biosciences Research Laboratory, Fargo, ND 58105 5674, USA
    J Anim Sci 80:1240-9. 2002
    ..The objectives of this study were to measure the residues of ractopamine in livers and kidneys of cattle (n = 6), sheep (n = 6), and ducks (n = 9) after treatment with dietary ractopamine for seven (sheep, ducks) or eight (cattle) ..
  56. ncbi Differentiation of prion protein glycoforms from naturally occurring sheep scrapie, sheep-passaged scrapie strains (CH1641 and SSBP1), bovine spongiform encephalopathy (BSE) cases and Romney and Cheviot breed sheep experimentally inoculated with BSE using
    Michael James Stack
    Veterinary Laboratories Agency, Woodham Lane, Addlestone, Surrey KT15 3NB, UK
    Acta Neuropathol 104:279-86. 2002
    ..prion protein (PrP) glycoforms showed that three distinctions can be made between natural ovine scrapie cases and sheep experimentally inoculated with bovine spongiform encephalopathy (BSE)...
  57. ncbi Atypical scrapie in sheep from a UK research flock which is free from classical scrapie
    Hugh A Simmons
    Animal Services Unit, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK
    BMC Vet Res 5:8. 2009
    In the wake of the epidemic of bovine spongiform encephalopathy the British government established a flock of sheep from which scrapie-free animals are supplied to laboratories for research...
  58. ncbi Serum antibody isotype responses of Fasciola-infected sheep and cattle to excretory and secretory products of Fasciola species
    I K Phiri
    Department of Clinical Studies, School of Veterinary Medicine, University of Zambia, P O Box 32379, Lusaka, Zambia
    Vet Parasitol 141:234-42. 2006
    This study investigated the immunoglobulin isotype responses of sheep and cattle chronically infected with Fasciola hepatica and Fasciola gigantica to adult F. hepatica excretory/secretory products (Fh-ES) or F...
  59. ncbi Onset and distribution of tissue prp accumulation in scrapie-affected suffolk sheep as demonstrated by sequential necropsies and tonsillar biopsies
    M Jeffrey
    Lasswade Veterinary Laboratory, Veterinary Laboratories Agency, Pentlands Science Park, Penicuik, Midlothian, EH26 0PZ, UK
    J Comp Pathol 125:48-57. 2001
    ..of immunohistochemically detectable PrP were present in a minority of follicles from tonsillar biopsies of young lambs, but by 14 months of age widespread PrP accumulation, affecting many or even all follicles, was present...
  60. ncbi PrP genotyping of Austrian sheep breeds
    W Sipos
    II Medical Clinic for Ruminants and Swine, University of Veterinary Medicine, Vienna, Austria
    J Vet Med A Physiol Pathol Clin Med 49:415-8. 2002
    Scrapie, an ovine and caprine transmissible spongiforme encephalopathy, is widely spread among sheep populations in many European countries...
  61. ncbi Arsenic metabolism in seaweed-eating sheep from Northern Scotland
    J Feldmann
    University of Aberdeen, Department of Chemistry, Scotland, UK
    Fresenius J Anal Chem 368:116-21. 2000
    ..The arsenic species were determined in seaweed extracts and in the urine and blood serum of seaweed-eating sheep from Northern Scotland...
  62. ncbi Seasonal dynamics of the Karoo paralysis tick (Ixodes rubicundus): a comparative study on Merino and Dorper sheep
    L J Fourie
    Department of Zoology and Entomology, University of the Orange Free State, Bloemfontein, South Africa
    Onderstepoort J Vet Res 63:273-6. 1996
    ..It has been shown previously that Angora goats are at a higher risk of being paralysed than Merino sheep, and such differences have been related to differences in feeding behaviour and spatial distribution of the two ..
  63. ncbi Novel endothelin receptor antagonist attenuates endotoxin-induced lung injury in sheep
    Vladimir N Kuklin
    Departments of Anesthesiology, Faculty of Medicine, University of Tromsø, Norway
    Crit Care Med 32:766-73. 2004
    To evaluate the cardiopulmonary effects of the novel endothelin receptor antagonist tezosentan in endotoxin-induced lung injury in sheep and to assess the dose response to tezosentan and endothelin-1 in healthy sheep.
  64. ncbi The effects of condensed tannins supplementation of foods with different protein content on parasitism, food intake and performance of sheep infected with Trichostrongylus colubriformis
    S Athanasiadou
    Animal Nutrition and Health Department, Animal Biology Division, Scottish Agricultural College, West Mains Road, Edinburgh EH9 3JG, UK
    Br J Nutr 86:697-706. 2001
    ..properties and (2), the nutritional consequences of commercially available condensed tannins on parasitised sheep fed, ad libitum, either a high- or a low-protein food...
  65. ncbi Evaluation of the FAMACHA system for detecting the severity of anaemia in sheep from southern Italy
    Antonio Di Loria
    Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, University of Naples Federico II, Via Delpino 1 80137 Naples, Italy
    Vet Parasitol 161:53-9. 2009
    ..in different geographic area where Haemonchus contortus is the major gastrointestinal (GI) strongyle species of sheep. The present study, the first on the use of the FAMACHA system in Italy, was aimed at obtaining a complete ..
  66. ncbi Risk of subacute ruminal acidosis in sheep with separate access to forage and concentrate
    L Commun
    UR1213 Herbivores, INRA Theix, F 63122 Saint Genes Champanelle, France
    J Anim Sci 87:3372-9. 2009
    This study aimed to investigate whether sheep offered free-choice intake of forage and concentrate develop subacute ruminal acidosis (SARA) and to identify SARA-associated feeding behavior components...
  67. ncbi Analysis of mitochondrial DNA indicates that domestic sheep are derived from two different ancestral maternal sources: no evidence for contributions from urial and argali sheep
    S Hiendleder
    Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
    J Hered 89:113-20. 1998
    To investigate the origins and phylogenetic relationships of domestic sheep, mitochondrial DNA (mtDNA) from 243 sheep of five European, one African, and four Asian breeds and several mouflon (Ovis musimon), urial (O...
  68. ncbi Pruritus is a common feature in sheep infected with the BSE agent
    Timm Konold
    Veterinary Laboratories Agency Weybridge, Woodham Lane, Addlestone, UK
    BMC Vet Res 4:16. 2008
    The variability in the clinical or pathological presentation of transmissible spongiform encephalopathies (TSEs) in sheep, such as scrapie and bovine spongiform encephalopathy (BSE), has been attributed to prion protein genotype, strain, ..
  69. ncbi Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep
    Jan P M Langeveld
    Central Institute for Animal Disease Control Lelystad CIDC Lelystad, PO Box 2004, 8203 AA, Lelystad, The Netherlands
    BMC Vet Res 2:19. 2006
    Diagnosis based on prion detection in lymph nodes of sheep and goats can improve active surveillance for scrapie and, if it were circulating, for bovine spongiform encephalopathy (BSE)...
  70. ncbi HCO3- transport in relation to mucus secretion from submucosal glands
    N S Joo
    Cystic Fibrosis Research Laboratory, Stanford University Stanford, CA 94305 2130, USA
    JOP 2:280-4. 2001
    The role of HCO(3)(-) transport in relation to fluid secretion by submucosal glands is being studied in sheep, pigs, cats and humans...
  71. ncbi Ovine lentivirus is aetiologically associated with chronic respiratory disease of sheep on the Laikipia Plateau in Kenya
    P M Rwambo
    Global Livestock Collaborative Research Support Program GL CRSP, Kenya Agricultural Research Institute, Nairobi
    Trop Anim Health Prod 33:471-87. 2001
    A study was undertaken to investigate the occurrence of ovine lentivirus (OvLV) infection in sheep with chronic respiratory disease on the Laikipia Plateau, Kenya...
  72. ncbi Mannheimia (Pasteurella) haemolytica leukotoxin utilizes CD18 as its receptor on bighorn sheep leukocytes
    Weiguo Liu
    Department of Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    J Wildl Dis 43:75-81. 2007
    Pneumonia caused by Mannheimia (Pasteurella) haemolytica is a highly fatal disease of bighorn sheep (Ovis canadensis). Leukotoxin (Lkt), secreted by M...
  73. ncbi The effects of urea supplementation on production and parasitological responses of sheep infected with Haemonchus contortus and Trichostrongylus colubriformis
    M R Knox
    CSIRO Animal Production, Pastoral Research Laboratory, Armidale, NSW, Australia
    Vet Parasitol 83:123-35. 1999
    Merino wether lambs were individually confined and fed a basal diet of oaten chaff containing essential minerals which was untreated or contained 3% urea. Within each dietary group animals were orally infected with either 200 H...
  74. ncbi Seroprevalence of toxoplasmosis in sheep in South Africa
    N Abu Samra
    Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110 South Africa
    J S Afr Vet Assoc 78:116-20. 2007
    Serum samples from 600 sheep were collected from 5 different provinces randomly chosen in South Africa...
  75. ncbi rhBMP-12 accelerates healing of rotator cuff repairs in a sheep model
    Howard J Seeherman
    Women s Health and Musculoskeletal Biology, Wyeth Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 90:2206-19. 2008
    ..This study was performed to evaluate the ability of recombinant human bone morphogenetic protein-12 (rhBMP-12), administered in several carriers, to accelerate healing in a sheep model of rotator cuff repair.
  76. ncbi Intensive rotational grazing assists control of gastrointestinal nematodosis of sheep in a cool temperate environment with summer-dominant rainfall
    A F Colvin
    Centre for Animal Health and Welfare, School of Rural Science and Agriculture, University of New England, NSW 2351, Australia
    Vet Parasitol 153:108-20. 2008
    ..This study evaluated GIN over 2 years in three classes of fine wool Merino sheep (lambs, hoggets and ewes) under three different sheep management systems in a cool tableland environment near Armidale ..
  77. ncbi Protozoan infections (Toxoplasma gondii, Neospora caninum and Sarcocystis spp.) in sheep and goats: recent advances
    D Buxton
    Division of Virology, Moredun Research Institute, International Research Centre, Scotland, UK
    Vet Res 29:289-310. 1998
    The protozoan parasite Toxoplasma gondii is a serious cause of fetal mortality in sheep and goats. Oocysts, the parasite stage responsible for initiating infection, are produced following a primary infection in cats...
  78. ncbi The effect of Saccharomyces cerevisiae and Aspergillus oryzae on the digestion of the cell wall fraction of a mixed diet in defaunated and refaunated sheep rumen
    J P Jouany
    INRA, SRNH, Centre de Clermont Theix, Saint Genes Champanelle, France
    Reprod Nutr Dev 38:401-16. 1998
    ..SC) and Aspergillus oryzae (AO), without their culture medium, on the digestion of plant cell wall components in sheep that had been successively defaunated and refaunated...
  79. ncbi Dietary protein reduction in sheep and goats: different effects on L-alanine and L-leucine transport across the brush-border membrane of jejunal enterocytes
    B Schroder
    Department of Physiology, School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany
    J Comp Physiol B 173:511-8. 2003
    ..Ten sheep lambs, 8 weeks of age and 19-27 kg body weight, were allotted to two dietary regimes with either adequate or reduced ..
  80. ncbi Reduced lymphatic drainage of dialysate from the peritoneal cavity during acute peritonitis in sheep
    H Rodela
    Trauma Research Program, Sunnybrook Health Science Centre, Toronto, Ontario, Canada
    Perit Dial Int 16:163-71. 1996
    ..was to investigate the effects of acute peritonitis on lymphatic drainage of the peritoneal cavity in conscious sheep. DESIGN: Peritonitis was induced with the addition of 1% casein or 1% albumin to the dialysis solution...
  81. ncbi Phylogenetic diversity of Pasteurellaceae and horizontal gene transfer of leukotoxin in wild and domestic sheep
    Scott T Kelley
    Department of Biology, 5500 Campanile Drive, San Diego State University, San Diego, CA 92182, United States
    Infect Genet Evol 7:13-23. 2007
    ..and cross-transmission rates of Pasteurellaceae bacteria in populations of bighorn sheep, Dall's sheep, domestic sheep and domestic goats...
  82. ncbi Intravenous and intrapulmonary administration of honey solution to healthy sheep: effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride-induced liver injury
    Noori S Al-Waili
    Dubai Specialized Medical Center and Medical Research Laboratories, Islamic Establishment for Education, Dubai, United Arab Emirates
    J Med Food 6:231-47. 2003
    ..Healthy sheep of either sex, 6-8 months old, were assigned randomly into the following groups: sheep received i.v...
  83. ncbi Selection for anthelmintic resistance by macrocyclic lactones in Haemonchus contortus
    L F Le Jambre
    CSIRO Division of Animal Production, Pastoral Research Laboratory, Armidale, NSW, Australia
    Int J Parasitol 29:1101-11. 1999
    ..The experimental animals were adult sheep and lambs. In the controls where there was no anthelmintic selection, the proportion of CAVRS in the adult worm population ..
  84. ncbi In vivo anthelmintic activity of Dorycnium rectum and grape seed extract against Ostertagia (Teladorsagia) circumcincta and Trichostrongylus colubriformis in sheep
    T S Waghorn
    AgResearch Ltd, Grasslands Research Centre, Private Bag 11008, Palmerston North, New Zealand
    N Z Vet J 54:21-7. 2006
    ..seeds (GSE), against two species of parasite, Teladorsagia (Ostertagia) circumcincta and Trichostrongylus colubriformis, at different stages of their life cycle, in sheep that were parasite-naïve or previously exposed to nematodes.
  85. ncbi Prevalence and seasonal changes in the population of gastrointestinal nematodes of small ruminants in the semi-arid zone of north-eastern Nigeria
    C O Nwosu
    Department of Veterinary Microbiology and Parasitology, University of Maiduguri, P M B 1069 Maiduguri, Borno State, Nigeria
    Vet Parasitol 144:118-24. 2007
    ..out to determine the prevalence and seasonal abundance of the egg and adult stages of nematode parasites of sheep and goats in the semi-arid zone of north-eastern Nigeria between January and December 2002...
  86. ncbi The effect of feeding sulla (Hedysarum coronarium) or lucerne (Medicago sativa) on lamb parasite burdens and development of immunity to gastrointestinal nematodes
    J H Niezen
    AgResearch Grasslands, P O Box 11008, Palmerston North, New Zealand
    Vet Parasitol 105:229-45. 2002
    ..1 was aimed to show whether the lower faecal egg count (FEC) and larval establishment previously reported in lambs grazing sulla were due to direct effects of the forage on Ostertagia circumcincta and Trichostrongylus ..
  87. ncbi An ecologic study comparing distribution of Pasteurella trehalosi and Mannheimia haemolytica between Sierra Nevada bighorn sheep, White Mountain bighorn sheep, and domestic sheep
    Letizia Tomassini
    Washington State University, PO Box 646610, Pullman, Washington 99164 6610, USA
    J Wildl Dis 45:930-40. 2009
    ..Nevada bighorn sheep (Ovis canadensis sierrae), White Mountain bighorn sheep (Ovis canadensis nelsoni), and domestic sheep (Ovis aries) from California, USA, were compared...
  88. ncbi European Union's rapid TSE testing in adult cattle and sheep: implementation and results in 2001 and 2002
    Sheila M Bird
    MRC Biostatistics Unit, Cambridge, UK
    Stat Methods Med Res 12:261-78. 2003
    ..The major transmissible spongiform encephalopathy (TSE) which affects sheep and goats is scrapie. Passive surveillance of scrapie is associated with substantial under-reporting...
  89. ncbi Pulsed-field gel electrophoresis profile homogeneity of Mycobacterium avium subsp. paratuberculosis isolates from cattle and heterogeneity of those from sheep and goats
    Iker Sevilla
    Instituto Vasco de Investigacion y Desarrollo Agrario NEIKER, Berreaga, Derio, Bizkaia, Spain
    BMC Microbiol 7:18. 2007
    ..classify paratuberculosis isolates in two main types, cattle type strains, found affecting all host species, and sheep type strains, reported affecting mainly sheep...
  90. ncbi Influence of colostrum deprivation and concurrent Cryptosporidium parvum infection on the colonization and persistence of Escherichia coli O157 : H7 in young lambs
    R M La Ragione
    Department of Food and Environmental Safety, Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK
    J Med Microbiol 55:819-28. 2006
    ..Colostrum protects neonates against gastrointestinal pathogens, and orphan lambs, which are common on petting farms, may be deprived of this protection...
  91. ncbi Selective allergy to sheep's and goat's milk proteins
    T Muñoz Martín
    Allergy Service, Hospital Ramon y Cajal, Madrid, Spain
    Allergol Immunopathol (Madr) 32:39-42. 2004
    ..We describe a 2-year-old boy who experienced allergic reactions after eating and touching sheep's cheese, but who tolerated cow's milk and cow's milk dairy products...
  92. ncbi Total lipids of Sarda sheep meat that include the fatty acid and alkenyl composition and the CLA and trans-18:1 isomers
    Viviana Santercole
    Faculty of Veterinary Medicine, University of Sassari, 07100, Sassari, Italy
    Lipids 42:361-82. 2007
    The total lipids of the longissimus dorsi muscle were analyzed from commercial adult Sarda sheep in Sardina taken from local abattoirs, and in the subsequent year from three local farms in the Sassari region that provided some ..
  93. ncbi Surgical treatment for different forms of hernias in sheep and goats
    Fahd A Al-Sobayil
    Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Qassim, Saudi Arabia
    J Vet Sci 8:185-91. 2007
    b>Sheep and goats are frequently presented with different forms of hernias to veterinary clinics...
  94. ncbi Effects of nutritionally induced metabolic acidosis with or without glutamine infusion on acid-base balance, plasma amino acids, and plasma nonesterified fatty acids in sheep
    N E Odongo
    Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada
    J Anim Sci 87:1077-84. 2009
    ..induced metabolic acidosis with or without Gln infusion on acid-base balance, plasma AA, and plasma NEFA in sheep. In a randomized complete block design with a 2 x 2 factorial arrangement of treatments, 24 fully fleeced sheep (..
  95. ncbi Transmission of Mannheimia haemolytica from domestic sheep (Ovis aries) to bighorn sheep (Ovis canadensis): unequivocal demonstration with green fluorescent protein-tagged organisms
    Paulraj K Lawrence
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Wildl Dis 46:706-17. 2010
    Previous studies demonstrated that bighorn sheep (Ovis canadensis) died of pneumonia when commingled with domestic sheep (Ovis aries) but did not conclusively prove that the responsible pathogens were transmitted from domestic to bighorn ..
  96. ncbi The incidence of genotypes at codon 171 of the prion protein gene (PRNP) in five breeds of sheep and production traits of ewes associated with those genotypes
    B M Alexander
    University of Wyoming, Laramie 82071, USA
    J Anim Sci 83:455-9. 2005
    ..Genotyping was performed on 532 ewes and 901 lambs from the University of Wyoming flock, in addition to 820 rams from 52 sheep producers from Wyoming and surrounding ..
  97. ncbi Serotypes and analysis of distribution of Shiga toxin producing Escherichia coli from cattle and sheep in the lower North Island, New Zealand
    A L Cookson
    Rumen Microbial Functional Genomics Group, Metabolism and Microbial Genomics, AgResearch Ltd, Grasslands Research Centre, Private Bag 11008, Palmerston North, New Zealand
    N Z Vet J 54:78-84. 2006
    ..of STEC and enteropathogenic Escherichia coli (EPEC) amongst cattle (calves, heifers and dairy) and sheep (lambs, rams and ewes), to assess whether carriage of identified bacterial genotypes may be associated with a particular ..
  98. ncbi Are white-spot lesions in kidneys in sheep associated with leptospirosis?
    S Dorjee
    Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand
    N Z Vet J 57:28-33. 2009
    ..the association between white-spot lesions in kidneys and serological and cultural prevalence of leptospirosis in sheep, and to evaluate the diagnostic value of these lesions in individual sheep and lines of sheep at slaughter as ..
  99. ncbi Evaluation of confirmatory stains used for direct microscopic somatic cell counting of sheep milk
    K H Petersson
    Department of Fisheries, Animal and Veterinary Science, University of Rhode Island, Kingston, RI 02881, USA
    J Dairy Sci 94:1908-12. 2011
    ..cell counting and the direct microscopic somatic cell count (DMSCC), differ for the detection of abnormal milk in sheep and goats...
  100. ncbi Validation of the FAMACHA eye color chart for detecting clinical anemia in sheep and goats on farms in the southern United States
    R M Kaplan
    Department of Medical Microbiology and Parasitology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Vet Parasitol 123:105-20. 2004
    Recent studies on sheep and goat farms in the southern United States indicate that multiple-anthelmintic resistance in Haemonchus contortus is becoming a severe problem...

Research Grants93

  1. Characterization of de novo generation of infectious prions
    Joaquin Castilla; Fiscal Year: 2009
    ..e. Bovine spongiform encephalopathy (BSE) in US cattle and Nor98 (atypical scrapie) in New Zealand sheep, provide evidence that this infrequent spontaneous phenomenon may occur naturally...
  2. Assessing the Transmissibility of CWD to Humans
    Qingzhong Kong; Fiscal Year: 2010
    ..to humans directly (Aim 1)? Can CWD be transmitted to humans after passage through secondary hosts (cattle or sheep) (Aim 2)? Has CWD transmission to humans already occurred (Aim 3)? The ultimate goals are to define the risks of ..
  3. Assessing the Transmissibility of CWD to Humans
    Qingzhong Kong; Fiscal Year: 2009
    ..to humans directly (Aim 1)? Can CWD be transmitted to humans after passage through secondary hosts (cattle or sheep) (Aim 2)? Has CWD transmission to humans already occurred (Aim 3)? The ultimate goals are to define the risks of ..
  4. Assessing the Transmissibility of CWD to Humans
    Qingzhong Kong; Fiscal Year: 2007
    ..to humans directly (Aim 1)? Can CWD be transmitted to humans after passage through secondary hosts (cattle or sheep) (Aim 2)? Has CWD transmission to humans already occurred (Aim 3)? The ultimate goals are to define the risks of ..
  5. Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
    Anthony E Kincaid; Fiscal Year: 2010
    ..spread of prion disease between animals, such as chronic wasting disease in deer and elk, and scrapie in sheep and goats...
  6. FETAL REFLEX RESPONSES TO CEREBRAL HYPOPERFUSION
    Charles Wood; Fiscal Year: 1999
    Fetal sheep respond to hypotension with reflex hormonal and hemodynamic responses which return blood pressure to normal levels...
  7. Surgery to Prevent Postinfarction Ventricular Remodeling
    Robert Gorman; Fiscal Year: 2004
    ..valve geometry and border zone expansion that occurs after ventricular remodeling in three different infarct sheep models...
  8. Exchangeable Heart Valve for Tissue Engineering Applications
    Ivan Vesely; Fiscal Year: 2007
    ..Progress in this field has been hampered by the cost of the experimental model - the juvenile sheep that has a tissue-engineered valve implanted in the aortic position...
  9. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Robert Drake; Fiscal Year: 2001
    ..The first specific aim is to test if lung connective tissue is increased and late phase edema occurs in a sheep model of elevated Pc...
  10. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    ..The first specific aim is to test if lung connective tissue is increased and late phase edema occurs in a sheep model of elevated Pc...
  11. Renal Transporters and Fetal Neuroendocrinology
    Charles Wood; Fiscal Year: 2009
    ..are to identify the mechanisms controlling the activity of the hypothalamus-pituitary-adrenal (HPA) axis in fetal sheep. Providing a more complete understanding of the activity of the HPA axis will be key to understanding fetal stress,..
  12. Renal Transporters and Fetal Neuroendocrinology
    Charles Wood; Fiscal Year: 2009
    ..are to identify the mechanisms controlling the activity of the hypothalamus-pituitary-adrenal (HPA) axis in fetal sheep. Providing a more complete understanding of the activity of the HPA axis will be key to understanding fetal stress,..
  13. Renal Transporters and Fetal Neuroendocrinology
    Charles E Wood; Fiscal Year: 2010
    ..are to identify the mechanisms controlling the activity of the hypothalamus-pituitary-adrenal (HPA) axis in fetal sheep. Providing a more complete understanding of the activity of the HPA axis will be key to understanding fetal stress,..
  14. DEVELOPMENT OF THE SENSE OF TASTE
    Charlotte Mistretta; Fiscal Year: 1993
    ..neurophysiological and neuroanatomical studies of the development of salt taste sensation in fetal and postnatal sheep are proposed, to test ideas related to formation of receptive fields and related characteristics of taste neurons...
  15. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
    ..Our preliminary studies using sheep as a model revealed that prenatal exposure to the plasticizer bisphenol A (BPA), an environmentally pervasive ..
  16. Biomechanical optimization of TE heart valves
    Michael Sacks; Fiscal Year: 2007
    Recently, Kaushal et al. isolated endothelial progenitor cells (EPCs) from the peripheral blood of sheep and seeded them onto decellularized porcine iliac vessels...
  17. Biomechanical optimization of TE heart valves
    Michael S Sacks; Fiscal Year: 2010
    Recently, Kaushal et al. isolated endothelial progenitor cells (EPCs) from the peripheral blood of sheep and seeded them onto decellularized porcine iliac vessels...
  18. Thyroid regulation of cardiomyocyte maturation
    KENT L R THORNBURG; Fiscal Year: 2010
    In fetal sheep, cardiomyocytes gradually cease dividing and become binucleated (terminal differentiation) at ~100 days of a 145 day gestational period...
  19. KDR--A NOVEL FUNCTIONAL HEMATOPOIETIC STEM CELL MARKER
    Cesare Peschle; Fiscal Year: 2004
    ..The KDR+ fraction comprises virtually all HSCs, i.e., repopulating HSCs assayed in NOD-SCID mice and fetal sheep xenografts, and putative HSCs assayed in 12-wk extended Dexter type long term culture (ELTC) as ELTC-initiating ..
  20. CONTROL OF CORTICOTROPIN DURING PREGNANCY
    Maureen Keller Wood; Fiscal Year: 1993
    During pregnancy in sheep and in human beings plasma cortisol concentrations are increased without the compensatory decrease in plasma ACTH concentrations that would be expected with cortisol feedback inhibition of ACTH...
  21. Alterations of complex behaviors in sheep by pre-natal bisphenol A exposure
    Theresa M Lee; Fiscal Year: 2010
    ..Studies in rodents have implicated prenatal BPA exposure in a variety of health problems. We propose to use sheep as a model to examine the effects of prenatal BPA on complex behaviors...
  22. Molecular Basis of BMP-15 Function
    Shunichi Shimasaki; Fiscal Year: 2006
    ..Recent studies of a naturally occurring mutation in sheep [Inverdale (FecX')] have suggested an essential role for BMP-15 in folliculogenesis and fertility...