thirteen-lined ground squirrel

Summary

Alias: Ictidomys tridecemlineatus, Spermophilus tridecemlineatus, Citellus tridecemlineatus, Spermophilus tridecemlineatus (Mitchill, 1821)

Top Publications

  1. Tessier S, Storey K. Myocyte enhancer factor-2 and cardiac muscle gene expression during hibernation in thirteen-lined ground squirrels. Gene. 2012;501:8-16 pubmed publisher
    ..glucose transporter 4, and myomesin 1) would aid cardiac muscle of thirteen-lined ground squirrels (Ictidomys tridecemlineatus) in meeting challenges associated with hibernation...
  2. Tessier S, Storey K. Expression of myocyte enhancer factor-2 and downstream genes in ground squirrel skeletal muscle during hibernation. Mol Cell Biochem. 2010;344:151-62 pubmed publisher
    ..of selected downstream targets would aid the skeletal muscle of thirteen-lined ground squirrels (Spermophilus tridecemlineatus) in meeting metabolic challenges associated with winter hibernation; e.g...
  3. Neves F, Abrantes J, Lopes A, Fusinatto L, Magalhães M, van der Loo W, et al. Evolution of CCL16 in Glires (Rodentia and Lagomorpha) shows an unusual random pseudogenization pattern. BMC Evol Biol. 2019;19:59 pubmed publisher
    ..These observations suggest that the CCL16 had different evolutionary constrains in the Glires group that could be associated with the CCL16 biological function. ..
  4. MacCannell A, Sinclair K, Tattersall G, McKenzie C, Staples J. Identification of a lipid-rich depot in the orbital cavity of the thirteen-lined ground squirrel. J Exp Biol. 2019;222: pubmed publisher
    ..Histology shows blood vessels in close proximity to each other, suggesting it may serve as a vascular rete, perhaps to preferentially warm the eye and brain during arousals. ..
  5. Hampton M, Nelson B, Andrews M. Circulation and metabolic rates in a natural hibernator: an integrative physiological model. Am J Physiol Regul Integr Comp Physiol. 2010;299:R1478-88 pubmed publisher
    ..electrocardiogram and body temperature data from hibernating thirteen-lined ground squirrels (Spermophilus tridecemlineatus)...
  6. MacCannell A, Sinclair K, McKenzie C, Staples J. Environmental temperature effects on adipose tissue growth in a hibernator. J Exp Biol. 2019;222: pubmed publisher
    ..not influence the pattern of mass gain or BAT and WAT volume in the thirteen-lined ground squirrel (Ictidomys tridecemlineatus)...
  7. Frigault J, Gaudet J, Morin P. Investigating Nrf2-associated non-coding RNAs in the hibernating ground squirrel, Ictidomys tridecemlineatus. J Therm Biol. 2018;75:38-44 pubmed publisher
    ..including Keap1 was conducted using qRT-PCR in hibernating hearts of the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. Elevated Nrf2 levels and reduced miR-200a levels were notably observed in hibernating versus euthermic ..
  8. Morin M, Lang Ouellette D, Lyons P, Crapoulet N, Morin P. Characterization of miRNAs modulated by torpor in the hibernating ground squirrel Ictidomys tridecemlineatus liver by next-generation sequencing. Cryo Letters. 2017;38:269-277 pubmed
    ..a signature of cold torpor-associated miRNAs in the hibernating thirteen-lined ground squirrel Ictidomys tridecemlineatus. Next-generation sequencing and qRT-PCR approaches were conducted in euthermic and hibernating ground ..
  9. Fujino K, Horie M, Honda T, Merriman D, Tomonaga K. Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome. Proc Natl Acad Sci U S A. 2014;111:13175-80 pubmed publisher
    ..An EBLN element in the genome of the thirteen-lined ground squirrel (Ictidomys tridecemlineatus), itEBLN, encodes an ORF with 77% amino acid sequence identity to the current bornavirus nucleoprotein...

More Information

Publications49

  1. VERMILLION K, Anderson K, Hampton M, Andrews M. Gene expression changes controlling distinct adaptations in the heart and skeletal muscle of a hibernating mammal. Physiol Genomics. 2015;47:58-74 pubmed publisher
    Throughout the hibernation season, the thirteen-lined ground squirrel (Ictidomys tridecemlineatus) experiences extreme fluctuations in heart rate, metabolism, oxygen consumption, and body temperature, along with prolonged fasting and ..
  2. Rouble A, Hawkins L, Storey K. Roles for lysine acetyltransferases during mammalian hibernation. J Therm Biol. 2018;74:71-76 pubmed publisher
    The thirteen-lined ground squirrel (Ictidomys tridecemlineatus) is a well-known model for studying hibernation...
  3. Li W, Chen S, DeVries S. A fast rod photoreceptor signaling pathway in the mammalian retina. Nat Neurosci. 2010;13:414-6 pubmed publisher
    ..By recording from pairs of rods and Off cone bipolar cells in the ground squirrel (Spermophilus tridecemlineatus), we measured the synaptic responses of mammalian rods unfiltered by the slow kinetics of the rod ..
  4. Ferris E, Abegglen L, Schiffman J, Gregg C. Accelerated Evolution in Distinctive Species Reveals Candidate Elements for Clinically Relevant Traits, Including Mutation and Cancer Resistance. Cell Rep. 2018;22:2742-2755 pubmed publisher
    ..Additionally, ARs in the six species are associated with specific human clinical phenotypes that have apparent concordance with overt traits in each species. ..
  5. Zhang Y, Storey K. Expression of nuclear factor of activated T cells (NFAT) and downstream muscle-specific proteins in ground squirrel skeletal and heart muscle during hibernation. Mol Cell Biochem. 2016;412:27-40 pubmed publisher
    The thirteen-lined ground squirrel (Ictidomys tridecemlineatus) undergoes remarkable adaptive changes during hibernation...
  6. MacCannell A, Jackson E, Mathers K, Staples J. An improved method for detecting torpor entrance and arousal in a mammalian hibernator using heart rate data. J Exp Biol. 2018;221: pubmed publisher
    We used electrocardiogram (ECG) telemeters to measure the heart rate of hibernating Ictidomys tridecemlineatus (thirteen-lined ground squirrel). An increase in heart rate from 2...
  7. Rouble A, Storey K. Characterization of the SIRT family of NAD+-dependent protein deacetylases in the context of a mammalian model of hibernation, the thirteen-lined ground squirrel. Cryobiology. 2015;71:334-43 pubmed publisher
    ..liver, brown adipose and white adipose tissues of the hibernating thirteen-lined ground squirrel (Ictidomys tridecemlineatus) over the course of the torpor-arousal cycle...
  8. Ballinger M, Hess C, Napolitano M, Bjork J, Andrews M. Seasonal changes in brown adipose tissue mitochondria in a mammalian hibernator: from gene expression to function. Am J Physiol Regul Integr Comp Physiol. 2016;311:R325-36 pubmed publisher
    ..the BAT mitochondrial proteome and mitochondrial bioenergetics in the thirteen-lined ground squirrel (Ictidomys tridecemlineatus) across four time points: spring, fall, torpor, and IBA...
  9. Zhang Y, Tessier S, Storey K. Inhibition of skeletal muscle atrophy during torpor in ground squirrels occurs through downregulation of MyoG and inactivation of Foxo4. Cryobiology. 2016;73:112-9 pubmed publisher
    ..Therefore, this data provides novel insight into the molecular mechanisms regulating muscle remodeling in a hibernator model. ..
  10. Luu B, Biggar K, Wu C, Storey K. Torpor-responsive expression of novel microRNA regulating metabolism and other cellular pathways in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. FEBS Lett. 2016;590:3574-3582 pubmed publisher
    ..novel microRNA regulating gene expression during hibernation in thirteen-lined ground squirrels, Ictidomys tridecemlineatus. A group of 17 novel microRNA was identified, and their relative expression was quantitated using real-..
  11. Ruberto A, Childers C, Storey K. Purification and properties of glycerol-3-phosphate dehydrogenase from the liver of the hibernating ground squirrel, Urocitellus richardsonii. Comp Biochem Physiol B Biochem Mol Biol. 2016;202:48-55 pubmed publisher
    ..In addition, using the protein sequence of the hibernating thirteen-lined ground squirrel (Ictidomys tridecemlineatus) and bioinformatics tools, a three-dimensional model of G3PDH was built to identify the potential ..
  12. Tessier S, Zhang Y, Wijenayake S, Storey K. MAP kinase signaling and Elk1 transcriptional activity in hibernating thirteen-lined ground squirrels. Biochim Biophys Acta Gen Subj. 2017;1861:2811-2821 pubmed publisher
    ..We identify regulation of JNK and Elk1 in the skeletal muscle of hibernating I. tridecemlineatus. ..
  13. MacCannell A, Sinclair K, Friesen Waldner L, McKenzie C, Staples J. Water-fat MRI in a hibernator reveals seasonal growth of white and brown adipose tissue without cold exposure. J Comp Physiol B. 2017;187:759-767 pubmed publisher
    ..We hypothesized that in the thirteen-lined ground squirrel (Ictidomys tridecemlineatus), a hibernator, BAT growth is regulated, in part, by an endogenous rhythm and we predicted that this ..
  14. Morin P, Storey K. Cloning and expression of hypoxia-inducible factor 1alpha from the hibernating ground squirrel, Spermophilus tridecemlineatus. Biochim Biophys Acta. 2005;1729:32-40 pubmed
    ..was quantified at both gene and protein levels in four organs of the thirteen-lined ground squirrel, Spermophilus tridecemlineatus. Reverse transcription-PCR showed no change in hif-1alpha transcript levels in the liver, lung, ..
  15. Eddy S, Morin P, Storey K. Cloning and expression of PPAR-gamma and PGC-1alpha from the hibernating ground squirrel, Spermophilus tridecemlineatus. Mol Cell Biochem. 2005;269:175-82 pubmed
    ..and the PPARgamma co-activator (PGC-1alpha) have been cloned from the hibernating ground squirrel, Spermophilus tridecemlineatus and show differential regulation during hibernation at the mRNA level using relative RT-PCR and at the ..
  16. Mamady H, Storey K. Coping with the stress: expression of ATF4, ATF6, and downstream targets in organs of hibernating ground squirrels. Arch Biochem Biophys. 2008;477:77-85 pubmed publisher
    ..of multiple markers of the UPR in tissues of euthermic (control) versus hibernating ground squirrels, Spermophilus tridecemlineatus. Immunoblot analysis of ATF4 protein expression revealed strong increases of 1.9- to 2...
  17. Laursen W, Schneider E, Merriman D, Bagriantsev S, Gracheva E. Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels. Proc Natl Acad Sci U S A. 2016;113:11342-11347 pubmed
    ..Here, we show that thirteen-lined ground squirrels (Ictidomys tridecemlineatus) and Bactrian camels (Camelus ferus) express TRPV1 orthologs with dramatically reduced temperature ..
  18. Morin P, Storey K. Antioxidant defense in hibernation: cloning and expression of peroxiredoxins from hibernating ground squirrels, Spermophilus tridecemlineatus. Arch Biochem Biophys. 2007;461:59-65 pubmed
    ..of peroxiredoxins contributes to antioxidant defense during torpor in thirteen-lined ground squirrels, Spermophilus tridecemlineatus. Expression levels of three isozymes of the 2-Cys peroxiredoxin (Prdx) family were quantified by ..
  19. Bera T, Hahn Y, Lee B, Pastan I. TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. Biochem Biophys Res Commun. 2003;312:1209-15 pubmed
    ..Selective expression of TEPP in testis, prostate, and in placenta and its high conservation among different species indicate that TEPP might have a role in reproductive biology. ..
  20. Weiss E, Raman D, Shirakawa S, Ducceschi M, Bertram P, Wong F, et al. The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas. Mol Vis. 1998;4:27 pubmed
    ..The presence of this kinase in cones in the ground squirrel and its ability to phosphorylate rhodopsin suggests that it could function in cone cells as a cone opsin kinase...
  21. Schwartz C, Hampton M, Andrews M. Hypothalamic gene expression underlying pre-hibernation satiety. Genes Brain Behav. 2015;14:310-8 pubmed publisher
    Prior to hibernation, 13-lined ground squirrels (Ictidomys tridecemlineatus) enter a hypophagic period where food consumption drops by an average of 55% in 3 weeks...
  22. Luu B, Tessier S, Duford D, Storey K. The regulation of troponins I, C and ANP by GATA4 and Nkx2-5 in heart of hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus. PLoS ONE. 2015;10:e0117747 pubmed publisher
    ..The heart of hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus) has the remarkable ability to descend to low, near 0°C temperatures without falling into cardiac ..
  23. Denner J. Expression and function of endogenous retroviruses in the placenta. APMIS. 2016;124:31-43 pubmed publisher
    ..It is important to emphasize that during evolution different species utilized ('enslaved') different endogenous retroviruses and that two or more endogenous retroviruses are involved in placentogenesis in each species. ..
  24. Revsbech I, Tufts D, Projecto Garcia J, Moriyama H, Weber R, Storz J, et al. Hemoglobin function and allosteric regulation in semi-fossorial rodents (family Sciuridae) with different altitudinal ranges. J Exp Biol. 2013;216:4264-71 pubmed publisher
  25. Zhang L, Storey K, Yu D, Hu Y, Zhang J. The complete mitochondrial genome of Ictidomys tridecemlineatus (Rodentia: Sciuridae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:2608-9 pubmed publisher
    The complete mitochondrial genome of the thirteen-lined ground squirrel, Ictidomys tridecemlineatus (Rodentia: Sciuridae) was sequenced to analyze the gene arrangement...
  26. Redelsperger F, Cornelis G, Vernochet C, Tennant B, Catzeflis F, Mulot B, et al. Capture of syncytin-Mar1, a fusogenic endogenous retroviral envelope gene involved in placentation in the Rodentia squirrel-related clade. J Virol. 2014;88:7915-28 pubmed publisher
    ..order, the squirrel-related clade, taking advantage of the complete sequencing of the ground squirrel Ictidomys tridecemlineatus genome...
  27. Bauer V, Swaffield J, Johnston S, Andrews M. CADp44: a novel regulatory subunit of the 26S proteasome and the mammalian homolog of yeast Sug2p. Gene. 1996;181:63-9 pubmed
    ..CADp44, based on the analysis of cDNAs derived from the brainstem of the 13-lined ground squirrel, Spermophilus tridecemlineatus. CADp44 has an unmodified molecular mass of 44,178 Da and contains multiple functional domains, ..
  28. Hahn Y. Molecular evolution of TEPP protein genes in metazoans. Biochem Genet. 2009;47:651-64 pubmed publisher
    ..No homolog was detected in birds, insects, nematodes, and teleost fishes despite the extensive sequence data of these species, implying that the TEPP gene might be lost in these lineages. ..
  29. Morin P, Ni Z, McMullen D, Storey K. Expression of Nrf2 and its downstream gene targets in hibernating 13-lined ground squirrels, Spermophilus tridecemlineatus. Mol Cell Biochem. 2008;312:121-9 pubmed publisher
    ..Nrf2 mRNA and protein expression were enhanced in selected organs of 13-lined ground squirrels, Spermophilus tridecemlineatus during hibernation. Furthermore, Nrf2 protein in heart was elevated by 1.4-1...
  30. Vidal L, Lugo N. Changes in neuropeptide Y immunoreactivity and transcript levels in circadian system structures of the diurnal rodent, the thirteen-lined ground squirrel. Brain Res. 2006;1125:77-84 pubmed
    ..Our data provide the first evidence of the relationship between transcript and peptide levels in the circadian system of a diurnal species. ..
  31. Lee Y, Miyake S, Wakita H, McMullen D, Azuma Y, Auh S, et al. Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells. J Cereb Blood Flow Metab. 2007;27:950-62 pubmed publisher
    ..These data indicate that post-translational modification of proteins by SUMOylation is a prominent feature of hibernation torpor and is critical for cytoprotection by ischemic PC+/-hypothermia in SHSY5Y cells subjected to OGD...
  32. Mamady H, Storey K. Up-regulation of the endoplasmic reticulum molecular chaperone GRP78 during hibernation in thirteen-lined ground squirrels. Mol Cell Biochem. 2006;292:89-98 pubmed publisher
    ..study evaluated the GRP78 response in seven organs of hibernating thirteen-lined ground squirrels, Spermophilus tridecemlineatus. Transcript levels of grp78, assessed by RT-PCR, were significantly higher (3.5- to 4...
  33. Cai D, McCarron R, Hallenbeck J. Cloning and characterization of a forkhead transcription factor gene, FoxO1a, from thirteen-lined ground squirrel. Gene. 2004;343:203-9 pubmed
    ..research analyzes the regulation of ischemic tolerance in hibernating thirteen-lined ground squirrels (Spermophilus tridecemlineatus)...
  34. Squire T, Lowe M, Bauer V, Andrews M. Pancreatic triacylglycerol lipase in a hibernating mammal. II. Cold-adapted function and differential expression. Physiol Genomics. 2003;16:131-40 pubmed publisher
    Thirteen-lined ground squirrels (Spermophilus tridecemlineatus) exploit the low-temperature activity of pancreatic triacylglycerol lipase (PTL) during hibernation...
  35. Squire T, Andrews M. Pancreatic triacylglycerol lipase in a hibernating mammal. I. Novel genomic organization. Physiol Genomics. 2003;16:119-30 pubmed publisher
    ..lipase (PTL) is expressed in novel locations during hibernation in the thirteen-lined ground squirrel (Spermophilus tridecemlineatus)...
  36. Buck M, Squire T, Andrews M. Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal. Physiol Genomics. 2002;8:5-13 pubmed publisher
    ..hibernation in heart, skeletal muscle, and white adipose tissue (WAT) of the 13-lined ground squirrel, Spermophilus tridecemlineatus. During hibernation PDK4 mRNA levels increase 5-fold in skeletal muscle and 15-fold in WAT compared ..
  37. Hittel D, Storey K. Differential expression of adipose- and heart-type fatty acid binding proteins in hibernating ground squirrels. Biochim Biophys Acta. 2001;1522:238-43 pubmed
    ..A-FABPs) was detected during hibernation in brown adipose tissue (BAT) of 13-lined ground squirrels, Spermophilus tridecemlineatus, using a commercial rat cDNA array...
  38. Andrews M, Squire T, Bowen C, Rollins M. Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal. Proc Natl Acad Sci U S A. 1998;95:8392-7 pubmed
    ..the physiological characteristics of hibernation in the heart of the thirteen-lined ground squirrel (Spermophilus tridecemlineatus)...
  39. von Schantz M, Sz l A, van Veen T, Farber D. Cloning of a cyclic GMP phosphodiesterase gamma subunit from the ground squirrel retina. Brain Res Mol Brain Res. 1998;54:327-33 pubmed
    ..phosphodiesterase (PDE) had previously been found to label all photoreceptors in the ground squirrel (Spermophilus tridecemlineatus). This property was utilized for the cloning of a cDNA fragment encoding the corresponding polypeptide...
  40. Takamatsu N, Kojima M, Taniyama M, Ohba K, Uematsu T, Segawa C, et al. Expression of multiple alpha1-antitrypsin-like genes in hibernating species of the squirrel family. Gene. 1997;204:127-32 pubmed