Alias: house mouse, Mus musculus, LK3 transgenic mice, Mus sp. 129SV, nude mice, transgenic mice, Mus muscaris, mice C57BL/6xCBA/CaJ hybrid, Mus musculus Linnaeus, 1758

Top Publications

  1. Goswami S, Thierry Mieg D, Thierry Mieg J, Mishra S, Hoon M, Mannes A, et al. Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord. Mol Pain. 2014;10:44 pubmed publisher
    ..RNA-Seq demonstrates that GRP is not transcribed in mouse, rat, or human sensory ganglia...
  2. Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi N, et al. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 2014;514:380-4 pubmed publisher
    The study of cancer genes in mouse models has traditionally relied on genetically-engineered strains made via transgenesis or gene targeting in embryonic stem cells...
  3. Hsu I, Parkinson L, Shen Y, Toro A, Brown T, Zhao H, et al. Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing. Cell Death Dis. 2014;5:e1458 pubmed publisher
    ..In addition, GzmB-induced detachment of mouse embryonic fibroblasts correlated with a rounded and clustered phenotype that was prevented by SA3N...
  4. Vandormael Pournin S, Guigon C, Ishaq M, Coudouel N, Avé P, Huerre M, et al. Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells. Cell Death Differ. 2015;22:108-17 pubmed publisher
    ..Here, we report the striking reproductive features of a novel mouse model of POI obtained through oocyte-specific inactivation (ocKO) of Omcg1/Zfp830 encoding a nuclear zinc finger ..
  5. Tamarina N, Roe M, Philipson L. Characterization of mice expressing Ins1 gene promoter driven CreERT recombinase for conditional gene deletion in pancreatic β-cells. Islets. 2014;6:e27685 pubmed publisher
    ..We report the generation of a transgenic mouse line that enables a highly specific system for conditional gene manipulation within β-cells and achieve tissue ..
  6. Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature. 2014;512:69-73 pubmed publisher
    ..mechanisms leading to production of interleukin-1? in rheumatoid arthritis is limited by the absence of suitable mouse models of the disease in which inflammasomes contribute to pathology...
  7. Yuen B, Bush K, Barrilleaux B, Cotterman R, Knoepfler P. Histone H3.3 regulates dynamic chromatin states during spermatogenesis. Development. 2014;141:3483-94 pubmed publisher
    ..Recently, we developed a knockout mouse model for the H3f3b gene, one of two genes encoding H3.3...
  8. Goforth P, Leinninger G, Patterson C, Satin L, Myers M. Leptin acts via lateral hypothalamic area neurotensin neurons to inhibit orexin neurons by multiple GABA-independent mechanisms. J Neurosci. 2014;34:11405-15 pubmed publisher designer drugs) hyperpolarizes membrane potential and suppresses action potential firing in OX neurons in mouse hypothalamic slices...
  9. Wegener A, Deboux C, Bachelin C, Frah M, Kerninon C, Seilhean D, et al. Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination. Brain. 2015;138:120-35 pubmed publisher
    ..To decipher Olig2 functions, we generated transgenic mice (TetOlig2:Sox10(rtTA/+)) overexpressing Olig2 in Sox10(+) oligodendroglial cells in a doxycycline inducible ..

More Information

Publications195 found, 100 shown here

  1. Chen C, Hehnly H, Yu Q, Farkas D, Zheng G, Redick S, et al. A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation. Curr Biol. 2014;24:2327-2334 pubmed publisher
    ..All Pcnt(-/-) mouse tissues and cells examined showed spindle misorientation...
  2. Chávez A, Hernández V, Rodenas Ruano A, Chan C, Castillo P. Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus. J Neurosci. 2014;34:16621-9 pubmed publisher
    ..or by the endocannabinoid anandamide depresses somatic, but not dendritic inhibitory transmission in both rat and mouse dentate gyrus...
  3. Jais A, Einwallner E, Sharif O, Gossens K, Lu T, Soyal S, et al. Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man. Cell. 2014;158:25-40 pubmed publisher
    ..These findings identify HO-1 inhibition as a potential therapeutic strategy for metabolic disease. ..
  4. Tang Y, Gholamin S, Schubert S, Willardson M, Lee A, Bandopadhayay P, et al. Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat Med. 2014;20:732-40 pubmed publisher
    ..Notably, patient- and GEMM (genetically engineered mouse model)-derived Hedgehog-driven tumors (basal cell carcinoma, medulloblastoma and atypical teratoid rhabdoid tumor) ..
  5. Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, et al. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014;514:187-92 pubmed publisher
    ..Human caspase-4 and the mouse homologue caspase-11 (hereafter referred to as caspase-4/11) and also human caspase-5, directly bound to LPS and ..
  6. Zhang L, Shang X, Li H, Shi Y, Li W, Teves M, et al. Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells. Asian J Androl. 2015;17:86-93 pubmed publisher
    ..MORN3 mRNA is only abundant in mouse testis. In the testis, Morn3 mRNA is highly expressed in the spermiogenesis stage...
  7. Grimm C, Holdt L, Chen C, Hassan S, Müller C, Jörs S, et al. High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nat Commun. 2014;5:4699 pubmed publisher
    ..Embryonic mouse fibroblasts and hepatocytes lacking TPC2 display a profound impairment of LDL-cholesterol and EGF/EGF-receptor ..
  8. Rocha C, Papon L, Cacheux W, Marques Sousa P, Lascano V, Tort O, et al. Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon. EMBO J. 2014;33:2247-60 pubmed publisher
    ..Strikingly, higher proliferation is compensated by faster tissue turnover in normal colon. In a mouse model for tumorigenesis, lack of TTLL3 strongly promotes tumor development...
  9. Lin C, Koh F, Wong P, Conti M, Ramalho Santos M. Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote. Dev Cell. 2014;30:268-79 pubmed publisher
    ..We report that maternal Hira, a chaperone for the histone variant H3.3, is required for mouse development past the zygote stage...
  10. Viale A, Pettazzoni P, Lyssiotis C, Ying H, Sánchez N, Marchesini M, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014;514:628-32 pubmed publisher
    ..Here we explore the role of mutant KRAS in PDAC maintenance using a recently developed inducible mouse model of mutated Kras (Kras(G12D), herein KRas) in a p53(LoxP/WT) background...
  11. Platt R, Chen S, Zhou Y, Yim M, Swiech L, Kempton H, et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell. 2014;159:440-55 pubmed publisher
    ..To broadly enable the application of Cas9 in vivo, we established a Cre-dependent Cas9 knockin mouse. We demonstrated in vivo as well as ex vivo genome editing using adeno-associated virus (AAV)-, lentivirus-, or ..
  12. Jaehne E, Klarić T, Koblar S, Baune B, Lewis M. Effects of Npas4 deficiency on anxiety, depression-like, cognition and sociability behaviour. Behav Brain Res. 2015;281:276-82 pubmed publisher
    ..A mouse model of Npas4 deficiency has been developed to investigate any role in these disorders...
  13. Dorà N, Collinson J, Hill R, West J. Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxP sites. PLoS ONE. 2014;9:e109193 pubmed publisher
    ..Our observation that eye abnormalities can occur in hemizygous Le-Cre(Tg/-); Pax6(+/+) mice, in the absence of a floxed allele, demonstrates the importance of including all the relevant genetic controls in Cre-loxP experiments. ..
  14. Liu J, Voisin V, Wang S, Wang D, Jones R, Datti A, et al. Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. EMBO Mol Med. 2014;6:1542-60 pubmed publisher
    ..eukaryotic elongation factor-2 kinase (eEF2K) inhibitors as more potent than PI3K/AKT/mTOR inhibitors on both mouse and human Pten/p53-deficient TNBC cells. Sensitivity to eEF2K inhibition correlated with AKT pathway activity...
  15. Moffat C, Bhatia L, Nguyen T, LYNCH P, Wang M, Wang D, et al. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver. J Lipid Res. 2014;55:2458-70 pubmed publisher
    ..Using a model of adenoviral Acot2 overexpression in mouse liver (Ad-Acot2), we show that Acot2 increases the utilization of FA substrate during the daytime in ad libitum-..
  16. Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn D, et al. Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease. Mol Cell. 2014;56:311-22 pubmed publisher
    ..Here, we report that depletion of Mbnl proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events...
  17. Zigler J, Sinha D. βA3/A1-crystallin: more than a lens protein. Prog Retin Eye Res. 2015;44:62-85 pubmed publisher
    ..encoded by Cryba1, one of the 6 β-crystallin genes, using a spontaneous rat mutant and genetically engineered mouse models...
  18. Zieger M, Ahnelt P, Uhrin P. CX3CL1 (fractalkine) protein expression in normal and degenerating mouse retina: in vivo studies. PLoS ONE. 2014;9:e106562 pubmed publisher
    ..CX3CL1) protein expression in wild type (wt) retina and its alterations during retinal degeneration in mouse model (rd10) of retinitis pigmentosa...
  19. Rasmussen A, Okumura A, Ferris M, Green R, Feldmann F, Kelly S, et al. Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance. Science. 2014;346:987-91 pubmed publisher
    Existing mouse models of lethal Ebola virus infection do not reproduce hallmark symptoms of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated intravascular coagulation nor death from shock, thus restricting ..
  20. Shen L, Inoue A, He J, Liu Y, Lu F, Zhang Y. Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes. Cell Stem Cell. 2014;15:459-471 pubmed publisher
    ..Our study thus defines the respective functions of Tet3 and DNA replication in paternal DNA demethylation and reveals an unexpected contribution of Tet3 to demethylation of the maternal genome. ..
  21. Lindberg N, Jiang Y, Xie Y, Bolouri H, Kastemar M, Olofsson T, et al. Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells. J Neurosci. 2014;34:14644-51 pubmed publisher
    ..Here we show that mouse OPCs can give rise to both types of glioma given the right circumstances...
  22. Lee J, Perera R, Wang H, Wu D, Liu X, Han S, et al. Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci U S A. 2014;111:E3091-100 pubmed publisher
    ..the effects of genetic or pharmacologic inhibition of Hh pathway activity in three distinct genetically engineered mouse models and found that Hh pathway inhibition accelerates rather than delays progression of oncogenic Kras-driven ..
  23. García Caballero A, Gadotti V, Stemkowski P, Weiss N, Souza I, Hodgkinson V, et al. The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity. Neuron. 2014;83:1144-58 pubmed publisher
    ..2 channels via intrathecal delivery of Tat peptides mediates analgesia in both inflammatory and neuropathic mouse models of mechanical hypersensitivity...
  24. Lee D, Liu Y, Liao L, Wang F, Xu J. The prostate basal cell (BC) heterogeneity and the p63-positive BC differentiation spectrum in mice. Int J Biol Sci. 2014;10:1007-17 pubmed publisher
    ..We generated a p63-CreERT2 knock-in mouse line that expresses tamoxifen-inducible Cre activity in the p63-expressing cells, including the prostate BCs...
  25. Ozawa T, Riester M, Cheng Y, Huse J, Squatrito M, Helmy K, et al. Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma. Cancer Cell. 2014;26:288-300 pubmed publisher
    ..These predictions were validated using mouse modeling, showing that PDGFA is sufficient to induce proneural-like gliomas and that additional NF1 loss converts ..
  26. Nakayama S, Sng N, Carretero J, Welner R, Hayashi Y, Yamamoto M, et al. β-catenin contributes to lung tumor development induced by EGFR mutations. Cancer Res. 2014;74:5891-902 pubmed publisher
    ..and genetic deletion of the β-catenin gene dramatically reduced lung tumor formation in EGFR-L858R-T790M transgenic mice. These data suggest that β-catenin plays an essential role in lung tumorigenesis and that targeting the Î..
  27. Hu R, Kagele D, Huffaker T, Runtsch M, Alexander M, Liu J, et al. miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. Immunity. 2014;41:605-19 pubmed publisher
    ..Using a mouse model of age-dependent inflammation that results from a deficiency in miR-146a, we demonstrate that miR-155 ..
  28. Jansen R, Duijst S, Mahakena S, Sommer D, Szeri F, Varadi A, et al. ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report. Arterioscler Thromb Vasc Biol. 2014;34:1985-9 pubmed publisher
    ..The current study was performed to determine which tissues release ATP in an ABCC6-dependent manner in vivo, where released ATP is converted into AMP and PPi, and whether human PXE ptients have low plasma PPi concentrations...
  29. Makarewich C, Zhang H, Davis J, Correll R, Trappanese D, Hoffman N, et al. Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction. Circ Res. 2014;115:567-580 pubmed publisher
    ..Ca2+ influx through TRPC channels expressed after MI activates pathological cardiac hypertrophy and reduces contractility reserve. Blocking post-MI TRPC activity improved post-MI cardiac structure and function...
  30. Fucho R, Martinez L, Baulies A, Torres S, Tarrats N, Fernandez A, et al. ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. J Hepatol. 2014;61:1126-34 pubmed publisher
    ..Autophagic flux, determined in the presence of rapamycin and/or chloroquine, was lower in primary mouse hepatocytes (PMH) from ASMase(-/-) mice and accompanied by increased p62 levels, suggesting autophagic impairment...
  31. Suh J, Jonker J, Ahmadian M, Goetz R, Lackey D, Osborn O, et al. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2014;513:436-9 pubmed publisher
    ..Thus we have uncovered an unexpected, neomorphic insulin-sensitizing action for exogenous non-mitogenic human FGF1 with therapeutic potential for the treatment of insulin resistance and type 2 diabetes. ..
  32. Gogolla N, Takesian A, Feng G, Fagiolini M, Hensch T. Sensory integration in mouse insular cortex reflects GABA circuit maturation. Neuron. 2014;83:894-905 pubmed publisher
    ..We compared the emergence of multisensory integration (MSI) in the IC of behaviorally distinct mouse strains...
  33. Xue Y, Yuwen T, Zhu F, Skrynnikov N. Role of electrostatic interactions in binding of peptides and intrinsically disordered proteins to their folded targets. 1. NMR and MD characterization of the complex between the c-Crk N-SH3 domain and the peptide Sos. Biochemistry. 2014;53:6473-95 pubmed publisher
    ..The results of the combined NMR and MD study of this engineered system will be reported in the next part of this paper. ..
  34. Tierney M, Aydogdu T, Sala D, Malecova B, Gatto S, Puri P, et al. STAT3 signaling controls satellite cell expansion and skeletal muscle repair. Nat Med. 2014;20:1182-6 pubmed publisher
  35. Cosgun K, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, et al. Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell. 2014;15:227-38 pubmed publisher
    ..Previously we showed that mutations in the Kit receptor enhance engraftment of transplanted HSCs in the mouse. To generate an improved model for human HSC transplantation and analysis, we developed immune-deficient mouse ..
  36. Andersen J, Urbán N, Achimastou A, Ito A, Simic M, Ullom K, et al. A transcriptional mechanism integrating inputs from extracellular signals to activate hippocampal stem cells. Neuron. 2014;83:1085-97 pubmed publisher
    ..Our results support a model whereby Ascl1 integrates inputs from both stimulatory and inhibitory signals and converts them into a transcriptional program activating adult neural stem cells. ..
  37. Fitzgerald D, O Brien K, Young A, Fonseca Kelly Z, Rostami A, Gran B. Interferon regulatory factor (IRF) 3 is critical for the development of experimental autoimmune encephalomyelitis. J Neuroinflammation. 2014;11:130 pubmed publisher
    ..These data show that IRF3 plays a crucial role in development of Th17 responses and EAE and warrants investigation in human multiple sclerosis. ..
  38. Su X, Driscoll K, Yao G, Raed A, Wu M, Beales P, et al. Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein. Hum Mol Genet. 2014;23:5441-51 pubmed publisher
    ..Moreover, physical interactions between the BBS and ADPKD proteins may underline the overlapping renal phenotypes in these two diseases...
  39. Boyango I, Barash U, Naroditsky I, Li J, Hammond E, Ilan N, et al. Heparanase cooperates with Ras to drive breast and skin tumorigenesis. Cancer Res. 2014;74:4504-14 pubmed publisher
    ..In this study, we utilized nontransformed human MCF10A mammary epithelial cells and two genetic mouse models [Hpa-transgenic (Hpa-Tg) and knockout mice] to explore heparanase function at early stages of tumor ..
  40. Mandal P, Berger S, Pillay S, Moriwaki K, Huang C, Guo H, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014;56:481-95 pubmed publisher
    ..RIP3 therefore holds both necroptosis and apoptosis in balance through a Ripoptosome-like platform. This work highlights a common mechanism unveiling RHIM-driven apoptosis by therapeutic or genetic perturbation of RIP3. ..
  41. Castañeda J, Genzor P, van der Heijden G, Sarkeshik A, Yates J, Ingolia N, et al. Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice. EMBO J. 2014;33:1999-2019 pubmed publisher
    Pachytene piRNAs are a class of Piwi-interacting small RNAs abundant in spermatids of the adult mouse testis...
  42. Chen J, Long F. mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis. Development. 2014;141:2848-54 pubmed publisher
    ..Here we report that mTORC1 signaling is activated during limb cartilage development in the mouse embryo...
  43. Shen W, Li W, Hixon J, Bouladoux N, Belkaid Y, Dzutzev A, et al. Adaptive immunity to murine skin commensals. Proc Natl Acad Sci U S A. 2014;111:E2977-86 pubmed publisher
    ..These studies suggest a previously unrecognized role for T cells in controlling skin commensal bacteria and provide a mechanism to account for cutaneous infections and mycobacterial infections in T-cell-deficient patients. ..
  44. Goldberg R, Rubinstein A, Gil N, Hermano E, Li J, van der Vlag J, et al. Role of heparanase-driven inflammatory cascade in pathogenesis of diabetic nephropathy. Diabetes. 2014;63:4302-13 pubmed publisher
  45. Gil Sanz C, Landeira B, Ramos C, Costa M, M ller U. Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon. J Neurosci. 2014;34:10475-87 pubmed publisher
    ..Our findings suggest that defects in adherens junctions components in mice massively affects progenitor cell proliferation and leads to a double cortex-like phenotype...
  46. Harada Y, Hiasa M. Immunological identification of vesicular nucleotide transporter in intestinal L cells. Biol Pharm Bull. 2014;37:1090-5 pubmed
  47. Best S, Hutt K, Fu N, Vaillant F, Liew S, Hartley L, et al. Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary. Development. 2014;141:3159-64 pubmed publisher
    ..the role of this basally restricted transcription factor in the mammary gland, we generated a cre-inducible mouse model...
  48. Mielcarek M, Inuabasi L, Bondulich M, Muller T, Osborne G, Franklin S, et al. Dysfunction of the CNS-heart axis in mouse models of Huntington's disease. PLoS Genet. 2014;10:e1004550 pubmed publisher
    ..To unravel this mechanism, we employed the R6/2 transgenic and HdhQ150 knock-in mouse models of HD...
  49. Choi Y, Lee K, Ryu J, Kim H, Jeong A, Woo R, et al. Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e104121 pubmed publisher
    ..and the maturity of individual spines in primary hippocampal neurons from Tg2576 neurons, and also attenuates cognitive function deficits in Tg2576 mouse model of AD, suggesting that neuritin possesses a therapeutic potential for AD.
  50. Lavine K, Epelman S, Uchida K, Weber K, Nichols C, Schilling J, et al. Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart. Proc Natl Acad Sci U S A. 2014;111:16029-34 pubmed publisher
    ..These findings indicate that embryonic-derived macrophages are key mediators of cardiac recovery and suggest that therapeutics targeting distinct macrophage lineages may serve as novel treatments for heart failure. ..
  51. Allam R, Lawlor K, Yu E, Mildenhall A, Moujalled D, Lewis R, et al. Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO Rep. 2014;15:982-90 pubmed publisher
  52. Tan D, Zhou M, Kiledjian M, Tong L. The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA. Nat Struct Mol Biol. 2014;21:679-85 pubmed publisher
    ..Mutation in either site perturbs the Roquin-mediated degradation of HMGXB3 and IL6 mRNAs in human cells, demonstrating the importance of both sites for mRNA decay. ..
  53. Cornu M, Oppliger W, Albert V, Robitaille A, Trapani F, Quagliata L, et al. Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21. Proc Natl Acad Sci U S A. 2014;111:11592-9 pubmed publisher
    ..Finally, mTORC1 signaling correlated with FGF21 expression in human liver tumors, suggesting that treatment of glutamine-addicted cancers with mTOR inhibitors might have beneficial effects at both the tumor and whole-body level. ..
  54. Vanner R, Remke M, Gallo M, Selvadurai H, Coutinho F, Lee L, et al. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell. 2014;26:33-47 pubmed publisher
    ..Addressing functional heterogeneity and eliminating Sox2(+) cells presents a promising therapeutic paradigm for treatment of sonic hedgehog subgroup medulloblastoma. ..
  55. Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z, et al. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014;15:1126-33 pubmed publisher
    ..Together our results reveal a specific role for the RIP1-RIP3-DRP1 pathway in RNA virus-induced activation of the NLRP3 inflammasome and establish a direct link between inflammation and cell-death signaling pathways. ..
  56. Lu M, Lawrence D, Marsters S, Acosta Alvear D, Kimmig P, Mendez A, et al. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science. 2014;345:98-101 pubmed publisher
    ..Persistent ER stress built up intracellular DR5 protein, driving ligand-independent DR5 activation and apoptosis engagement via caspase-8. Thus, DR5 integrates opposing UPR signals to couple ER stress and apoptotic cell fate. ..
  57. Luhmann U, Carvalho L, Holthaus S, Cowing J, Greenaway S, Chu C, et al. The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors. Hum Mol Genet. 2015;24:128-41 pubmed publisher
  58. He M, Subramanian R, Bangs F, Omelchenko T, Liem K, Kapoor T, et al. The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment. Nat Cell Biol. 2014;16:663-72 pubmed publisher
    ..Instead, a central function of Kif7 in the mammalian Hh pathway is to control cilium architecture and to create a single cilium tip compartment, where Gli-Sufu activity can be correctly regulated. ..
  59. Zhang C, Jiang B, Li M, Zhu M, Peng Y, Zhang Y, et al. The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metab. 2014;20:526-40 pubmed publisher
    ..Our current study also emphasizes a general role of late endosome/lysosome in controlling metabolic programs. ..
  60. Lee M, Lim C, Lee Y, Park J, Sonn S, Lee M, et al. The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice. Nat Commun. 2014;5:4410 pubmed publisher
    ..These findings define Retnla as a novel therapeutic target for treating hypercholesterolaemia and atherosclerosis. ..
  61. Kaitsuka T, Katagiri C, Beesetty P, Nakamura K, Hourani S, Tomizawa K, et al. Inactivation of TRPM7 kinase activity does not impair its channel function in mice. Sci Rep. 2014;4:5718 pubmed publisher
    ..Our findings suggest that abolishing TRPM7 kinase activity does not impair its channel activity and kinase activity is not essential for regulation of mammalian Mg(2+) homeostasis. ..
  62. Kone M, Pullen T, Sun G, Ibberson M, Martinez Sanchez A, Sayers S, et al. LKB1 and AMPK differentially regulate pancreatic β-cell identity. FASEB J. 2014;28:4972-85 pubmed publisher
    ..Selective targeting of these enzymes may provide a new approach to maintaining β-cell function in some forms of diabetes. ..
  63. von Burg N, Chappaz S, Baerenwaldt A, Horvath E, Bose Dasgupta S, Ashok D, et al. Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses. Proc Natl Acad Sci U S A. 2014;111:12835-40 pubmed publisher
    ..Taken together, our data reveal a novel activation-dependent function of peripheral ILC3s in eliciting cognate CD4(+) T-cell immune responses. ..
  64. Gatto G, Morales D, Kania A, Klein R. EphA4 receptor shedding regulates spinal motor axon guidance. Curr Biol. 2014;24:2355-65 pubmed publisher
    ..Our study reveals a novel mechanism to regulate guidance decision at an intermediate target based on the modulation of ligand availability by the proteolytic processing of the receptor. ..
  65. Ma X, Yang P, Kaplan W, Lee B, Wu L, Yang J, et al. ISL1 regulates peroxisome proliferator-activated receptor ? activation and early adipogenesis via bone morphogenetic protein 4-dependent and -independent mechanisms. Mol Cell Biol. 2014;34:3607-17 pubmed publisher
    ..Our time course gene expression survey sets the stage for further studies to explore other early and immediate regulators. ..
  66. Liu S, Brind Amour J, Karimi M, Shirane K, Bogutz A, Lefebvre L, et al. Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells. Genes Dev. 2014;28:2041-55 pubmed publisher
    ..5 PGCs and postnatal hypogonadism in both sexes. Taken together, these observations reveal that SETDB1 is an essential guardian against proviral expression prior to the onset of de novo DNA methylation in the germline. ..
  67. Duan B, Cheng L, Bourane S, Britz O, Padilla C, Garcia Campmany L, et al. Identification of spinal circuits transmitting and gating mechanical pain. Cell. 2014;159:1417-1432 pubmed publisher
    ..Therefore, peripheral mechanical nociceptors and Aβ mechanoreceptors, together with spinal SOM(+) excitatory and Dyn(+) inhibitory neurons, form a microcircuit that transmits and gates mechanical pain. PAPERCLIP: ..
  68. Dooley H, Razi M, Polson H, Girardin S, Wilson M, Tooze S. WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol Cell. 2014;55:238-52 pubmed publisher
    ..WIPI2b binds the membrane surrounding Salmonella and recruits the Atg12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. ..
  69. Stangenberg L, Burzyn D, Binstadt B, Weissleder R, Mahmood U, Benoist C, et al. Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature. Proc Natl Acad Sci U S A. 2014;111:11419-24 pubmed publisher
    ..Experiments entailing pharmacological inhibitors, genetically deficient mouse strains, and global transcriptome analyses failed to associate the protective effect with a single nerve quality (..
  70. Saeed A, Duffort S, Ivanov D, Wang H, Laird J, Salomon R, et al. The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages. PLoS ONE. 2014;9:e106421 pubmed publisher
  71. Tourette C, Farina F, Vázquez Manrique R, Orfila A, Voisin J, Hernandez S, et al. The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity. PLoS Biol. 2014;12:e1001895 pubmed publisher
    ..Further investigation in Caenorhabditis elegans and mouse striatal cell models of HD provided a model in which the early-stage increase of Ryk promotes neuronal dysfunction ..
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