eastern European house mouse


Alias: Mus musculus musculus, Mus musculus hortulanus

Top Publications

  1. Yu Z, Crichton I, Tang S, Hui Y, Ricciotti E, Levin M, et al. Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proc Natl Acad Sci U S A. 2012;109:6727-32 pubmed publisher
    ..Promotion of atherogenesis by postnatal COX-2 deletion affords a mechanistic explanation for this observation. Coincident inhibition of FLAP may offer an approach to attenuating such a risk from NSAIDs. ..
  2. Barbieri S, Amadio P, Gianellini S, Tarantino E, Zacchi E, Veglia F, et al. Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner. Circulation. 2012;126:1373-84 pubmed publisher
  3. Liu B, Zhang Y, Zhu N, Li H, Luo W, Zhou Y. A vasoconstrictor role for cyclooxygenase-1-mediated prostacyclin synthesis in mouse renal arteries. Am J Physiol Renal Physiol. 2013;305:F1315-22 pubmed publisher
    ..Also, our data imply that endogenous COX-1-mediated PGI2 synthesis leads to vasoconstrictor activity and this could be an integral part of endothelium-derived mechanisms in regulating local renal vascular function. ..
  4. Skinner B, Bacon J, Rathje C, Larson E, Kopania E, Good J, et al. Automated Nuclear Cartography Reveals Conserved Sperm Chromosome Territory Localization across 2 Million Years of Mouse Evolution. Genes (Basel). 2019;10: pubmed publisher
    ..of the sex chromosomes and two autosomes in three mouse lineages (Mus musculus domesticus, Mus musculus musculus and Mus spretus)...
  5. Janoušek V, Wang L, Luzynski K, Dufková P, Vyskočilová M, Nachman M, et al. Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus. Mol Ecol. 2012;21:3032-47 pubmed publisher
    Studies of a hybrid zone between two house mouse subspecies (Mus musculus musculus and M. m...
  6. Campbell P, Good J, Dean M, Tucker P, Nachman M. The contribution of the Y chromosome to hybrid male sterility in house mice. Genetics. 2012;191:1271-81 pubmed publisher
    ..In house mice, the contribution of the Mus musculus musculus X chromosome to hybrid male sterility is large...
  7. Latour Y, Perriat Sanguinet M, Caminade P, Boursot P, Smadja C, Ganem G. Sexual selection against natural hybrids may contribute to reinforcement in a house mouse hybrid zone. Proc Biol Sci. 2014;281:20132733 pubmed publisher
    ..We tested this hypothesis in a unimodal hybrid zone between Mus musculus musculus and Mus musculus domesticus where a pattern of reinforcement was described and lower hybrid fitness ..
  8. Raveh S, Sutalo S, Thonhauser K, Thoß M, Hettyey A, Winkelser F, et al. Female partner preferences enhance offspring ability to survive an infection. BMC Evol Biol. 2014;14:14 pubmed publisher
    ..To test this hypothesis, we conducted a study with wild-derived house mice (Mus musculus musculus) in which females were experimentally mated either with their preferred or non-preferred male, and their ..
  9. White M, Steffy B, Wiltshire T, Payseur B. Genetic dissection of a key reproductive barrier between nascent species of house mice. Genetics. 2011;189:289-304 pubmed publisher
    ..we conducted an F2 intercross between wild-derived inbred strains from two subspecies of house mice, Mus musculus musculus and Mus musculus domesticus...

More Information

Publications120 found, 100 shown here

  1. Hassan M, Olijnik A, Frickel E, Saeij J. Clonal and atypical Toxoplasma strain differences in virulence vary with mouse sub-species. Int J Parasitol. 2019;49:63-70 pubmed publisher
    ..insight into the responses of individual mouse strains, representing strains of the genetically divergent Mus musculus musculus, Mus musculus castaneus and Mus musculus domesticus, to infection with individual clonal and atypical ..
  2. Frynta D, Kaftanová Eliášová B, Žampachová B, Voráčková P, Sadlova J, Landová E. Behavioural strategies of three wild-derived populations of the house mouse (Mus m. musculus and M. m. domesticus) in five standard tests of exploration and boldness: Searching for differences attributable to subspecies and commensalism. Behav Processes. 2018;157:133-141 pubmed publisher
    ..The focal population was non-commensal Mus musculus musculus from Northern Iran...
  3. Loire E, Tusso S, Caminade P, Severac D, Boursot P, Ganem G, et al. Do changes in gene expression contribute to sexual isolation and reinforcement in the house mouse?. Mol Ecol. 2017;26:5189-5202 pubmed publisher
    ..In the two European subspecies of house mice, Mus musculus musculus and Mus musculus domesticus, earlier studies have demonstrated olfactory-based assortative mate preference ..
  4. Goüy de Bellocq J, Baird S, Albrechtová J, Sobeková K, Piálek J. Murine cytomegalovirus is not restricted to the house mouse Mus musculus domesticus: prevalence and genetic diversity in the European house mouse hybrid zone. J Virol. 2015;89:406-14 pubmed publisher
    ..m. domesticus and Mus musculus musculus in order to investigate the occurrence of MCMV in two Mus subspecies and to test the limits of the ..
  5. Janoušek V, Munclinger P, Wang L, Teeter K, Tucker P. Functional organization of the genome may shape the species boundary in the house mouse. Mol Biol Evol. 2015;32:1208-20 pubmed publisher
    ..Here, we examine genomic characteristics of the species boundaries between two house mouse subspecies (Mus musculus musculus/M. m. domesticus). These taxa form a narrow semipermeable zone of secondary contact across Central Europe...
  6. Xu F, Chao T, Liang Y, Li K, Hu S, Wang M, et al. Genome Sequencing of Chromosome 1 Substitution Lines Derived from Chinese Wild Mice Revealed a Unique Resource for Genetic Studies of Complex Traits. G3 (Bethesda). 2016;6:3571-3580 pubmed publisher
    ..analysis showed that these chromosomes had a mosaic genome structure that dominantly originated from Mus musculus musculus and M. m. castaneus subspecies, except for the C57BL/6J-Chr1KM line from M. m...
  7. Larson E, Vanderpool D, Sarver B, Callahan C, Keeble S, Provencio L, et al. The Evolution of Polymorphic Hybrid Incompatibilities in House Mice. Genetics. 2018;209:845-859 pubmed publisher
    ..HMS) between two recently diverged subspecies of house mice, Mus musculus domesticus and Mus musculus musculus We found that polymorphic HMS has a surprisingly complex genetic basis, with contributions from at ..
  8. Poltorak A, Apalko S, Sherbak S. Wild-derived mice: from genetic diversity to variation in immune responses. Mamm Genome. 2018;29:577-584 pubmed publisher
    ..Recently, inbred strains from other mouse subspecies were established such as Mus musculus castaneus and Mus musculus musculus, which diverged from a shared common ancestor with Mus musculus domesticus more than one million years ago...
  9. Egydio F, Ribeiro D, Noguti J, Tufik S, Andersen M. Influence of sleep deprivation and morphine on the expression of inducible nitric oxide synthase and cyclooxygenase-2 in skin of hairless mice. Toxicol Mech Methods. 2012;22:577-83 pubmed publisher
    ..Sleep deprivation did not modulate outcomes induced by morphine. Morphine, not sleep loss, induces cyclooxygenase-2 and nitric oxide synthase immunoexpression in the skin of hairless mice. ..
  10. Das P, De T, Chakraborti T. Leishmania donovani secretory serine protease alters macrophage inflammatory response via COX-2 mediated PGE-2 production. Indian J Biochem Biophys. 2014;51:542-51 pubmed
  11. Musolf K, Meindl S, Larsen A, Kalcounis Rueppell M, Penn D. Ultrasonic Vocalizations of Male Mice Differ among Species and Females Show Assortative Preferences for Male Calls. PLoS ONE. 2015;10:e0134123 pubmed publisher
    ..of males from different Mus species, Mus musculus subspecies, and populations (F1 offspring of wild-caught Mus musculus musculus, Mus musculus domesticus (and F1 hybrid crosses), and Mus spicilegus), and we conducted playback ..
  12. Hiadlovská Z, Mikula O, Macholán M, Hamplová P, Vošlajerová Bímová B, Daniszová K. Shaking the myth: Body mass, aggression, steroid hormones, and social dominance in wild house mouse. Gen Comp Endocrinol. 2015;223:16-26 pubmed publisher
    ..Since Mus musculus domesticus is the subspecies which dominates mutual encounters with Mus musculus musculus we predicted higher growth rate, delayed puberty and aggression, and higher testosterone and ..
  13. Subramanian S. Effect of genetic drift on determinants of protein evolution. Biol Lett. 2018;14: pubmed publisher
    ..estimated for protein-coding genes of Mus musculus castaneus and Mus musculus musculus: populations with high and low Ne respectively...
  14. Cížková D, Baird S, Těšíková J, Voigt S, Ľudovít Ď, Piálek J, et al. Host subspecific viral strains in European house mice: Murine cytomegalovirus in the Eastern (Mus musculus musculus) and Western house mouse (Mus musculus domesticus). Virology. 2018;521:92-98 pubmed publisher
    ..The EastMCMV genome sequences reported here can therefore serve as a well-described resource for exploration of murid MCMV diversity. ..
  15. Jedinak A, Dudhgaonkar S, Wu Q, Simon J, Sliva D. Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-?B and AP-1 signaling. Nutr J. 2011;10:52 pubmed publisher
    ..Our study suggests that oyster mushroom possesses anti-inflammatory activities and could be considered a dietary agent against inflammation. The health benefits of the oyster mushroom warrant further clinical studies. ..
  16. Kashiwagi S, Hosono K, Suzuki T, Takeda A, Uchinuma E, Majima M. Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema. Lab Invest. 2011;91:1314-25 pubmed publisher
    ..The present study therefore suggests that lymphangiogenesis, together with recurrence of lymph flow after surgical induction of lymphedema, is upregulated by COX-2 possibly via generation of PGs. ..
  17. Alam S, Pal A, Kumar R, Dwivedi P, Das M, Ansari K. EGFR-mediated Akt and MAPKs signal pathways play a crucial role in patulin-induced cell proliferation in primary murine keratinocytes via modulation of Cyclin D1 and COX-2 expression. Mol Carcinog. 2014;53:988-98 pubmed publisher
    ..Inhibition of EGFR or the Ras/MAPKs, PI3/Akt pathways with different pharmacological inhibitors or knockdown of NF-?B, c-jun, c-fos, Cyclin D1, and COX-2 with siRNA inhibited PAT-induced PMKs proliferation. ..
  18. Kogiso M, Shinohara T, Dorey C, Shibata Y. Cholera toxin induces a shift from inactive to active cyclooxygenase 2 in alveolar macrophages activated by Mycobacterium bovis BCG. Infect Immun. 2013;81:373-80 pubmed publisher
    ..Our results indicate that inclusion of CT in the intranasal BCG vaccination enhances COX-2-mediated PGE(2) release by alveolar macrophages and further suggest that the effect of CT in vivo is mediated by other lung cells. ..
  19. Huang J, Yuan S, Wang D, Wu Q, Wang X, Pi C, et al. The role of COX-2 in mediating the effect of PTEN on BMP9 induced osteogenic differentiation in mouse embryonic fibroblasts. Biomaterials. 2014;35:9649-59 pubmed publisher
    ..Our findings suggest that PTEN plays an important role in regulating BMP9 induced osteogenic differentiation in MPCs, which may be mediated by PTEN/PI3K/Akt signaling to modulate the expression of COX-2. ..
  20. Wu J, Chen C, Hu X, Cai X, Guan Y, Hu H, et al. Suppressing cyclooxygenase-2 prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway. Biochem Biophys Res Commun. 2016;469:1034-40 pubmed publisher
    ..The findings suggested that suppressing COX-2 can improve steatohepatitis by inhibiting hepatocyte apoptosis in mice via regulating the Akt/p53 pathway. Celecoxib treatment may be a favorable treatment option for NASH. ..
  21. Kirkby N, Lundberg M, Wright W, Warner T, Paul Clark M, Mitchell J. COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks. PLoS ONE. 2014;9:e98165 pubmed publisher
  22. Tian J, Lambertz I, Berton T, Rundhaug J, Kiguchi K, Shirley S, et al. Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands. Mol Carcinog. 2012;51:973-83 pubmed publisher
    ..2011 Wiley Periodicals, Inc. ..
  23. Matsuzuka T, Miller K, Pickel L, Doi C, Ayuzawa R, Tamura M. The synergistic induction of cyclooxygenase-2 in lung fibroblasts by angiotensin II and pro-inflammatory cytokines. Mol Cell Biochem. 2009;320:163-71 pubmed publisher
    ..It is also suggested that the AT(1) receptor in lung fibroblasts may be a rational target for chemoprevention of lung cancer. ..
  24. Groó Z, Szenczi P, Bánszegi O, Nagy Z, Altbacker V. The influence of familiarity and temperature on the huddling behavior of two mouse species with contrasting social systems. Behav Processes. 2018;151:67-72 pubmed publisher
    ..of two closely related mouse species, the mound-building mouse (Mus spicilegus) and the house mouse (Mus musculus musculus). While their geographic distribution overlaps, their social systems differ in many aspects...
  25. Aikawa S, Kano K, Inoue A, Wang J, Saigusa D, Nagamatsu T, et al. Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways. EMBO J. 2017;36:2146-2160 pubmed publisher
    ..Our results indicate that ATX-LPA-LPA3 signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF and COX-2 pathways. ..
  26. Daniszová K, Mikula O, Macholan M, Pospíšilová I, Vošlajerová Bímová B, Hiadlovská Z. Subspecies-specific response to ACTH challenge test in the house mouse (Mus musculus). Gen Comp Endocrinol. 2017;252:186-192 pubmed publisher
    ..we measured concentrations of fecal glucocorticoid metabolites of two house mouse subspecies, Mus musculus musculus and M. m. domesticus...
  27. Zhuang Y, Zhao F, Liang J, Deng X, Zhang Y, Ding G, et al. Activation of COX-2/mPGES-1/PGE2 Cascade via NLRP3 Inflammasome Contributes to Albumin-Induced Proximal Tubule Cell Injury. Cell Physiol Biochem. 2017;42:797-807 pubmed publisher
    ..The findings suggest that COX-2/mPGES-1/PGE2 axis could be activated by albumin in the proximal tubular cells via a NLRP3 inflammasome-mediated mechanism and could thus contribute to proteinuria-related renal tubular cell injury. ..
  28. Liu D, Li X, Li H, Li X, Ye W. [Expression of cyclooxygenase-2 in a mouse macula densa cell lines and signal transduction of NF-kappaB and AP-1]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007;29:78-82 pubmed
    ..01). LS can induce the expression of COX-2 in MMDD1 cells, which may be involved in the activation of p38 MAP kinase, p44/42 kinase, AP-1, and NF-kappaB pathways. ..
  29. Xie Y, Chen R, Zhang X, Yu Y, Yang Y, Zou Y, et al. Blockade of interleukin-17A protects against coxsackievirus B3-induced myocarditis by increasing COX-2/PGE2 production in the heart. FEMS Immunol Med Microbiol. 2012;64:343-51 pubmed publisher
    ..These results hint that the Th17/IL-17 axis is intimately associated with viral replication in acute myocarditis via induction of COX-2 and prostaglandin E2. ..
  30. Hermankova B, Zajicova A, Javorkova E, Chudícková M, Trosan P, Hajkova M, et al. Suppression of IL-10 production by activated B cells via a cell contact-dependent cyclooxygenase-2 pathway upregulated in IFN-γ-treated mesenchymal stem cells. Immunobiology. 2016;221:129-36 pubmed publisher
    ..The results thus suggest that IFN-γ-treated MSCs strongly inhibit IL-10 production by activated B cells by a mechanism requiring cell contact and involving the Cox-2 pathway. ..
  31. Zhou J, Lei B, Li H, Zhu L, Wang L, Tao H, et al. MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cells. Cell Death Dis. 2017;8:e2597 pubmed publisher
    ..In addition, miR-144 regulated mGC apoptosis and affected follicular atresia, but these activities did not appear to be through COX-2 and Smad4. Taken together, we revealed an important CP2/miR-144/COX-2/PGE2/ovulation pathway in mGCs. ..
  32. Göbel C, Breitenbuecher F, Kalkavan H, Hähnel P, Kasper S, Hoffarth S, et al. Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity. Cell Death Dis. 2014;5:e1568 pubmed publisher
    ..In conclusion, COX-2, which is frequently induced in colorectal cancer, contributes to immune evasion and resistance to antigen-specific cancer immunotherapy by local suppression of T-cell effector functions. ..
  33. An Y, Belevych N, Wang Y, Zhang H, Herschman H, Chen Q, et al. Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge. J Neurosci Res. 2014;92:486-95 pubmed publisher
    ..Furthermore, COX-2-dependent neurotoxicity was mediated, at least in part, via the activation of the EP1 receptor. These results show that Cox-2 expression induced in different cell types can confer opposite effects. ..
  34. Carlson N, Rojas M, Redd J, Tang P, Wood B, Hill K, et al. Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death. J Neuroinflammation. 2010;7:25 pubmed publisher
    ..An understanding of how COX-2 expression influences oligodendrocyte death leading to demyelination may have important ramifications for future treatments for MS...
  35. Straiker A, Wager Miller J, Hu S, Blankman J, Cravatt B, Mackie K. COX-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation. Br J Pharmacol. 2011;164:1672-83 pubmed publisher
  36. Jurk D, Wilson C, Passos J, Oakley F, Correia Melo C, Greaves L, et al. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun. 2014;2:4172 pubmed publisher
    ..These data indicate that systemic chronic inflammation can accelerate ageing via ROS-mediated exacerbation of telomere dysfunction and cell senescence in the absence of any other genetic or environmental factor...
  37. Ohashi K, Ouchi N, Sato K, Higuchi A, Ishikawa T, Herschman H, et al. Adiponectin promotes revascularization of ischemic muscle through a cyclooxygenase 2-dependent mechanism. Mol Cell Biol. 2009;29:3487-99 pubmed publisher
    ..Thus, disruption of the adiponectin-COX-2 regulatory axis in endothelial cells could participate in the pathogenesis of obesity-related vascular diseases...
  38. Shweash M, Adrienne McGachy H, Schroeder J, Neamatallah T, Bryant C, Millington O, et al. Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression. Mol Immunol. 2011;48:1800-8 pubmed publisher
  39. Lee J, Sayers B, Chun K, Lao H, Shipley Phillips J, Bonner J, et al. Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages. Part Fibre Toxicol. 2012;9:14 pubmed publisher
    ..7 macrophages is ERK1,2-dependent, while iNOS induction by MWCNTs is ERK1,2-independent. Our data also suggest contributory physicochemical factors other than residual Ni catalyst play a role in COX-2 induction to MWCNT...
  40. Sierra J, Hobbs S, Chaturvedi R, Yan F, Wilson K, Peek R, et al. Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2013;305:G196-203 pubmed publisher
    ..Collectively, these findings indicate that aberrant activation of the EGFR-COX-2 axis may lower the threshold for carcinogenesis associated with chronic H. pylori infection. ..
  41. Dhar S, Ongwijitwat S, Wong Riley M. Nuclear respiratory factor 1 regulates all ten nuclear-encoded subunits of cytochrome c oxidase in neurons. J Biol Chem. 2008;283:3120-9 pubmed publisher
    ..Possible interactions between the NRFs will be investigated in the future...
  42. Gregorov S, Divina P, Storchova R, Trachtulec Z, Fotopulosova V, Svenson K, et al. Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies. Genome Res. 2008;18:509-15 pubmed publisher
    ..PWD-mt conplastic strain. A pilot-phenotyping experiment project revealed a high number of variations among B6.PWD consomics...
  43. Aljofan M, Ding H. High glucose increases expression of cyclooxygenase-2, increases oxidative stress and decreases the generation of nitric oxide in mouse microvessel endothelial cells. J Cell Physiol. 2010;222:669-75 pubmed publisher
  44. Yoshioka W, Higashiyama W, Tohyama C. Involvement of microRNAs in dioxin-induced liver damage in the mouse. Toxicol Sci. 2011;122:457-65 pubmed publisher
    ..In conclusion, this study demonstrated that TCDD dysregulates the expression of miR101a and miR122 and that COX-2, a target gene of miR101a, plays a significant role in liver damage in mice exposed to TCDD...
  45. A S, Bansal K, Holla S, Verma Kumar S, Sharma P, Balaji K. ESAT-6 induced COX-2 expression involves coordinated interplay between PI3K and MAPK signaling. Mol Immunol. 2012;49:655-63 pubmed publisher
    ..These findings would serve as a paradigm to understand pathogenesis of mycobacterial infection and clearly pave a way towards development of novel therapeutics...
  46. Khan A, Khan R, Qamar W, Lateef A, Rehman M, Tahir M, et al. Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: possible role of p38 MAP Kinase and NF-?B. Exp Mol Pathol. 2013;94:419-29 pubmed publisher
    ..Thus, our results suggest that GOH attenuates early tumor promotional changes, and it may serve as one of the various ways to prevent carcinogenesis...
  47. Park S, Chevallier N, Tejwani K, Hung M, Maruyama H, Golde T, et al. Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice. Biochem Biophys Res Commun. 2016;478:286-292 pubmed publisher
  48. Lu L, Loi F, Nathan K, Lin T, Pajarinen J, Gibon E, et al. Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway. J Orthop Res. 2017;35:2378-2385 pubmed publisher
    ..2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2378-2385, 2017. ..
  49. Ninomiya Y, Tanuma S, Tsukimoto M. Differences in the effects of four TRPV1 channel antagonists on lipopolysaccharide-induced cytokine production and COX-2 expression in murine macrophages. Biochem Biophys Res Commun. 2017;484:668-674 pubmed publisher
    ..These results suggest that at least some TRPV1 channel antagonists, such as AMG9810 and CPZ, may be candidate anti-inflammatory agents for treatment of sepsis. ..
  50. Dumont B. X-Chromosome Control of Genome-Scale Recombination Rates in House Mice. Genetics. 2017;205:1649-1656 pubmed publisher
    ..Previously, males from two interfertile subspecies of house mice, Mus musculus musculus and M. m...
  51. Pezer Z, Chung A, Karn R, Laukaitis C. Analysis of Copy Number Variation in the Abp Gene Regions of Two House Mouse Subspecies Suggests Divergence during the Gene Family Expansions. Genome Biol Evol. 2017;9: pubmed publisher
    ..copy number variation in this gene family in natural populations of Mus musculus domesticus ( Mmd ) and Mus musculus musculus ( Mmm ), two subspecies of house mice that form a narrow hybrid zone in Central Europe...
  52. Zala S, Reitschmidt D, Noll A, Balazs P, Penn D. Sex-dependent modulation of ultrasonic vocalizations in house mice (Mus musculus musculus). PLoS ONE. 2017;12:e0188647 pubmed publisher
    ..We recorded the USVs of wild-derived adult house mice (F1 of wild-caught Mus musculus musculus), and we compared the vocalizations of males and females in response to a stimulus mouse of the same- or ..
  53. Chung D, Yoo K, Hwang I, Kim D, Chung J, Lee C, et al. Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus. Cell Mol Neurobiol. 2010;30:531-41 pubmed publisher
  54. Ahmetaj Shala B, Kirkby N, Knowles R, Al Yamani M, Mazi S, Wang Z, et al. Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs. Circulation. 2015;131:633-42 pubmed publisher
    ..We identify the endogenous endothelial nitric oxide synthase inhibitor ADMA as a biomarker and mechanistic bridge between renal cyclooxygenase-2 inhibition and systemic vascular dysfunction. ..
  55. Kamata M, Hosono K, Fujita T, Kamata K, Majima M. Role of cyclooxygenase-2 in the development of interstitial fibrosis in kidneys following unilateral ureteral obstruction in mice. Biomed Pharmacother. 2015;70:174-80 pubmed publisher
    ..The present study demonstrates that COX-2 plays a protective role against fibrosis in UUO kidneys and suggests that supplementation of COX-2 products, such as PG analogues, will be a good option for preventing interstitial fibrosis. ..
  56. Pallares L, Ledevin R, Pantalacci S, Turner L, Steingrimsson E, Renaud S. Genomic regions controlling shape variation in the first upper molar of the house mouse. elife. 2017;6: pubmed publisher
    ..We explore the genetic basis of shape variation in the first upper molar of hybrid mice between Mus musculus musculus and M. m. domesticus...
  57. Bansal K, Kapoor N, Narayana Y, Puzo G, Gilleron M, Balaji K. PIM2 Induced COX-2 and MMP-9 expression in macrophages requires PI3K and Notch1 signaling. PLoS ONE. 2009;4:e4911 pubmed publisher
    ..Taken together, these data implicate PI3K and Notch1 signaling as obligatory early proximal signaling events during PIM2 induced COX-2 and MMP-9 expression in macrophages. ..
  58. Steenport M, Khan K, Du B, Barnhard S, Dannenberg A, Falcone D. Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: evidence for the role of TNF-alpha and cyclooxygenase-2. J Immunol. 2009;183:8119-27 pubmed publisher
    ..These data also suggest that this nexus is targetable utilizing anti-TNF-alpha therapies and/or selective EP4 antagonists...
  59. Yanni S, McCollum G, Penn J. Genetic deletion of COX-2 diminishes VEGF production in mouse retinal Müller cells. Exp Eye Res. 2010;91:34-41 pubmed publisher
    ..Our study suggests that PGE(2), signaling through the EP(2) and/or EP(4) receptor and PKA, mediates the VEGF response of Müller cells...
  60. Ishikawa T, Jain N, Herschman H. Cox-2 gene expression in chemically induced skin papillomas cannot predict subsequent tumor fate. Mol Oncol. 2010;4:347-56 pubmed publisher
    ..Elevated Cox-2 promoter-driven luciferase signal can be detected when papillomas first become visible, but not before this time...
  61. Brown J, Nemeth K, Kushnir Sukhov N, Metcalfe D, Mezey E. Bone marrow stromal cells inhibit mast cell function via a COX2-dependent mechanism. Clin Exp Allergy. 2011;41:526-34 pubmed publisher
    ..These observations support the concept that BMSCs have the ability to suppress MC activation and therefore could be the basis for a novel cell based therapeutic approach in the treatment of MC driven inflammatory diseases. ..
  62. Du H, Chen X, Zhang J, Chen C. Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-?. Br J Pharmacol. 2011;163:1533-49 pubmed publisher
    ..Our results suggest that CB(1) receptor-dependent PPAR? expression is an important and novel signalling pathway in endocannabinoid 2-AG-produced resolution of neuroinflammation in response to pro-inflammatory insults...
  63. Park E, Cheenpracha S, Chang L, Kondratyuk T, Pezzuto J. Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-?-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera. Nutr Cancer. 2011;63:971-82 pubmed publisher
    ..These data suggest RBITC should be included in the dietary armamentarium of isothiocyanates potentially capable of mediating antiinflammatory or cancer chemopreventive activity...
  64. Tan A, Konczak I, Ramzan I, Zabaras D, Sze D. Potential antioxidant, antiinflammatory, and proapoptotic anticancer activities of Kakadu plum and Illawarra plum polyphenolic fractions. Nutr Cancer. 2011;63:1074-84 pubmed publisher
    ..KPF5 also induced apoptosis and DNA damage in HT-29 cells, as determined by the cytokinesis block micronucleus cytome assay. ..
  65. Neilson A, Djuric Z, Ren J, Hong Y, Sen A, Lager C, et al. Effect of cyclooxygenase genotype and dietary fish oil on colonic eicosanoids in mice. J Nutr Biochem. 2012;23:966-76 pubmed publisher
    ..These results indicate that in normal colon, inhibition of COX-2 would have little effect on reducing PGE(2) levels. ..
  66. Fiebich B, Mu oz E, Rose T, Weiss G, McGregor G. Molecular targets of the antiinflammatory Harpagophytum procumbens (devil's claw): inhibition of TNF? and COX-2 gene expression by preventing activation of AP-1. Phytother Res. 2012;26:806-11 pubmed publisher
    ..This is novel evidence of a possible mechanism of action of this antiinflammatory drug...
  67. Weiss H, Wester Rosenloef L, Koch C, Koch F, Baltrusch S, Tiedge M, et al. The mitochondrial Atp8 mutation induces mitochondrial ROS generation, secretory dysfunction, and β-cell mass adaptation in conplastic B6-mtFVB mice. Endocrinology. 2012;153:4666-76 pubmed
    ..The Atp8 gene mutation caused mitochondrial dysfunction, apparently stimulating an adaptive increase of β-cell mass in response to HFD, whereas mitochondrial ROS might have had an supportive role. ..
  68. Akla N, Pratt J, Annabi B. Concanavalin-A triggers inflammatory response through JAK/STAT3 signalling and modulates MT1-MMP regulation of COX-2 in mesenchymal stromal cells. Exp Cell Res. 2012;318:2498-506 pubmed publisher
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    ..Our study not only has outlined a mechanism of elevated NF-?B activity and PGE2 production in senescent macrophages, but also provides RXR? as a potential therapeutic target for treating the age-related diseases. ..
  70. Basudhar D, Bharadwaj G, Cheng R, Jain S, Shi S, Heinecke J, et al. Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives. J Med Chem. 2013;56:7804-20 pubmed publisher
    ..Together, these anti-inflammatory, antineoplasic, and contractile properties suggest the potential of HNO-NSAIDs in the treatment of inflammation, cancer, or heart failure. ..
  71. Nam S, Kim J, Yoo D, Choi J, Kim W, Jung H, et al. Comparison of pharmacological and genetic inhibition of cyclooxygenase-2: effects on adult neurogenesis in the hippocampal dentate gyrus. J Vet Sci. 2015;16:245-51 pubmed
    ..Additionally, genetic inhibition of COX-2 strongly reduced neural stem cell populations, cell proliferation, and neuroblast differentiation in the dentate gyrus compared to pharmacological inhibition. ..
  72. Wang H, Li Y, Niu Y, Zheng J, Wu J, Shi G, et al. Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice. Inflammation. 2015;38:2269-78 pubmed publisher
    ..In conclusion, GL exerts significant anti-inflammatory and analgesic activities by attenuating the expression levels of TNF-α, IL-6, iNOS and COX-2. ..
  73. Lacroix A, Toussay X, Anenberg E, Lecrux C, Ferreirós N, Karagiannis A, et al. COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex. J Neurosci. 2015;35:11791-810 pubmed publisher
    ..These original findings will certainly change the current view of NVC. ..
  74. Tang S, Gao J, Wen S, Tong H, Yan Z, Liu R, et al. Expression of cyclooxygenase-2 is correlated with lncRNA-COX-2 in cirrhotic mice induced by carbon tetrachloride. Mol Med Rep. 2017;15:1507-1512 pubmed publisher
    ..These results suggest that expression of COX?2 and lncRNA?COX?2 increased with the progression of liver fibrosis. LncRNA-COX-2 may potentially be considered as a novel therapeutic target for liver fibrosis. ..
  75. Kang D, Yoon G, Cho J, Lee S, Lee S, Park H, et al. Neoagarooligosaccharides prevent septic shock by modulating A20-and cyclooxygenase-2-mediated interleukin-10 secretion in a septic-shock mouse model. Biochem Biophys Res Commun. 2017;486:998-1004 pubmed publisher
    ..Our data suggest that NAOs have a beneficial preventive effect in septic shock correlated with the enhancement of IL-10 via the induction of A20 and COX-2. ..
  76. Inagaki M, Nishimura T, Akanuma S, Nakanishi T, Tachikawa M, Tamai I, et al. Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts. Placenta. 2017;53:76-82 pubmed publisher
    ..Therefore, SynT-II could contribute to placental synthesis of PGE2 for release into the fetal-placental circulation. ..
  77. Park J, Shu L, Shayman J. Differential involvement of COX1 and COX2 in the vasculopathy associated with the alpha-galactosidase A-knockout mouse. Am J Physiol Heart Circ Physiol. 2009;296:H1133-40 pubmed publisher
    ..These results suggest that, in the Gla(-/0) mice, COX1 and COX2 activity are increased and localized in the endothelium, producing vasopressor and vasorelaxant products, which contribute to the Fabry-related vasculopathy...
  78. Park J, Sharma L, Li H, Xiang R, Holstein D, Wu J, et al. A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum Mol Genet. 2009;18:1578-89 pubmed publisher
    ..Our results indicate that the mtDNA mutations might play an important role in the early stage of cancer development, possibly through alteration of ROS generation and apoptosis...
  79. Lee J, Song H, Ju S, Lee S, Kwon H, Eum W, et al. Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells. Exp Mol Med. 2009;41:629-37 pubmed publisher
    ..Tat-SOD inhibited LPS-induced NF-kappaB DNA binding activity, IkappaBalpha degradation and activation of MAP kinases. These data suggest that SOD differentially regulate expression of iNOS and COX-2 in LPS-stimulated RAW 264.7 cells...
  80. el Azzouzi H, van Oort R, van der Nagel R, Sluiter W, Bergmann M, De Windt L. MEF2 transcriptional activity maintains mitochondrial adaptation in cardiac pressure overload. Eur J Heart Fail. 2010;12:4-12 pubmed publisher
  81. Ikeda Matsuo Y, Hirayama Y, Ota A, Uematsu S, Akira S, Sasaki Y. Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity. Br J Pharmacol. 2010;159:1174-86 pubmed publisher
    ..Microsomal prostaglandin E synthase-1 and COX-2 are co-induced by excess glutamate in ischaemic brain. These enzymes are co-localized and act together to exacerbate stroke injury, by excessive PGE(2) production...
  82. Shin J, Yun C, Cho Y, Baek N, Choi M, Jeong T, et al. Indole-containing fractions of Brassica rapa inhibit inducible nitric oxide synthase and pro-inflammatory cytokine expression by inactivating nuclear factor-?B. J Med Food. 2011;14:1527-37 pubmed publisher
    ..Taken together, our data suggest that the expressional inhibitions of iNOS, TNF-?, and IL-6 caused by an attenuation of NF-?B activation are responsible for the anti-inflammatory and antinociceptive activity of IBR. ..
  83. Fredenburgh L, Velandia M, Ma J, Olszak T, Cernadas M, Englert J, et al. Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol. 2011;187:5255-67 pubmed publisher
    ..Taken together, our results suggest that epithelial expression of COX-2 in the ileum is a critical modulator of tight junction protein expression and intestinal barrier function during sepsis...
  84. Lee W, Ahn G, Arachchillage J, Kim Y, Kim S, Lee B, et al. A polysaccharide isolated from Ecklonia cava fermented by Lactobacillus brevis inhibits the inflammatory response by suppressing the activation of nuclear factor-?B in lipopolysaccharide-induced RAW 264.7 macrophages. J Med Food. 2011;14:1546-53 pubmed publisher
    ..This study suggests that VLFEP exerts anti-inflammatory effects by down-regulating the production and expression of pro-inflammatory cytokines and mediators via inhibiting the NF-?B pathway in LPS-stimulated RAW 264.7 cells. ..
  85. Hamzic N, Blomqvist A, Nilsberth C. Immune-induced expression of lipocalin-2 in brain endothelial cells: relationship with interleukin-6, cyclooxygenase-2 and the febrile response. J Neuroendocrinol. 2013;25:271-80 pubmed publisher
    ..However, the effect of lipocalin-2 on fever is small, being sex-dependent and ambient temperature-specific, and thus lipocalin-2 cannot be considered as a major mediator of the IL-6-dependent fever generating pathway. ..
  86. Han S, Lee J, Kim C, Nam D, Chung W, Lee S, et al. Capillarisin inhibits iNOS, COX-2 expression, and proinflammatory cytokines in LPS-induced RAW 264.7 macrophages via the suppression of ERK, JNK, and NF-?B activation. Immunopharmacol Immunotoxicol. 2013;35:34-42 pubmed publisher
  87. Choo Wing R, Syed M, Harijith A, Bowen B, Pryhuber G, Jan r C, et al. Hyperoxia and interferon-?-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway. Am J Respir Cell Mol Biol. 2013;48:749-57 pubmed publisher
    ..Cox2, via CHOP, may significantly contribute to the final common pathway of hyperoxia-induced and IFN-?-mediated injury in developing lungs and human BPD...
  88. Zhou Y, Luo W, Zhang Y, Li H, Huang D, Liu B. Cyclo-oxygenase-1 or -2-mediated metabolism of arachidonic acid in endothelium-dependent contraction of mouse arteries. Exp Physiol. 2013;98:1225-34 pubmed publisher
    ..Moreover, our results imply that some of the PGI2 involved in vasoconstrictor activity of endothelial COX-mediated metabolism could possibly be generated from PGH2 in medial smooth muscle. ..
  89. Engstr m Ruud L, Wilhelms D, Eskilsson A, Vasilache A, Elander L, Engblom D, et al. Acetaminophen reduces lipopolysaccharide-induced fever by inhibiting cyclooxygenase-2. Neuropharmacology. 2013;71:124-9 pubmed publisher
  90. Boesen E. Chronic elevation of IL-1? induces diuresis via a cyclooxygenase 2-mediated mechanism. Am J Physiol Renal Physiol. 2013;305:F189-98 pubmed publisher
    ..05) and did not alter urinary Na? or K? excretion. These data indicate a critical role for COX-2 in mediating the effects of chronic IL-1? elevation on the kidney. ..
  91. Markosyan N, Chen E, Evans R, Ndong V, Vonderheide R, Smyth E. Mammary carcinoma cell derived cyclooxygenase 2 suppresses tumor immune surveillance by enhancing intratumoral immune checkpoint activity. Breast Cancer Res. 2013;15:R75 pubmed
    ..COX-2 inhibition may be clinically useful to augment breast cancer immunotherapy. ..
  92. Hayashi G, Shen Y, Pedersen T, Newman J, Pook M, Cortopassi G. Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. Hum Mol Genet. 2014;23:6838-47 pubmed publisher
    ..These findings support a neuroinflammatory mechanism in FRDA, which has both pathomechanistic and therapeutic implications. ..