golden hamster


Alias: Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Mesocricetus auratus, Golden hamsters, Syrian hamsters, Microcricetus aureus

Top Publications

  1. Melby P, Tryon V, Chandrasekar B, Freeman G. Cloning of Syrian hamster (Mesocricetus auratus) cytokine cDNAs and analysis of cytokine mRNA expression in experimental visceral leishmaniasis. Infect Immun. 1998;66:2135-42 pubmed
    The Syrian golden hamster (Mesocricetus auratus) is uniquely susceptible to a variety of intracellular pathogens and is an excellent model for a number of human infectious diseases...
  2. Kriegsfeld L, Mei D, Bentley G, Ubuka T, Mason A, Inoue K, et al. Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals. Proc Natl Acad Sci U S A. 2006;103:2410-5 pubmed
  3. Walter E, Stevens D, Visconte M, Millhauser G. The prion protein is a combined zinc and copper binding protein: Zn2+ alters the distribution of Cu2+ coordination modes. J Am Chem Soc. 2007;129:15440-1 pubmed
  4. Espitia C, Zhao W, Saldarriaga O, Osorio Y, Harrison L, Cappello M, et al. Duplex real-time reverse transcriptase PCR to determine cytokine mRNA expression in a hamster model of New World cutaneous leishmaniasis. BMC Immunol. 2010;11:31 pubmed publisher
    The Syrian hamster, Mesocricetus auratus, has distinct immunological features and is uniquely susceptible to intracellular pathogens. Studies in hamsters are limited by the relative unavailability of tools to conduct immunological studies...
  5. Basler K, Oesch B, Scott M, Westaway D, Wälchli M, Groth D, et al. Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell. 1986;46:417-28 pubmed
  6. Melby P, Chandrasekar B, Zhao W, Coe J. The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response. J Immunol. 2001;166:1912-20 pubmed
    ..Remarkably, infection of the Syrian hamster (Mesocricetus auratus) with L...
  7. Chattopadhyay M, Walter E, Newell D, Jackson P, Aronoff Spencer E, Peisach J, et al. The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4. J Am Chem Soc. 2005;127:12647-56 pubmed
    ..This work provides the first complete characterization of all dominant copper coordination modes at pH 7.4. ..
  8. Perez L, Chandrasekar B, Saldarriaga O, Zhao W, Arteaga L, Travi B, et al. Reduced nitric oxide synthase 2 (NOS2) promoter activity in the Syrian hamster renders the animal functionally deficient in NOS2 activity and unable to control an intracellular pathogen. J Immunol. 2006;176:5519-28 pubmed
  9. Osorio E, Zhao W, Espitia C, Saldarriaga O, Hawel L, Byus C, et al. Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression. PLoS Pathog. 2012;8:e1002417 pubmed publisher
    ..donovani infection induces macrophage STAT6 activation and STAT6-dependent arg1 expression, which do not require but are amplified by type 2 cytokines, and which contribute to impaired control of infection. ..

More Information

Publications231 found, 100 shown here

  1. Korf H. Signaling pathways to and from the hypophysial pars tuberalis, an important center for the control of seasonal rhythms. Gen Comp Endocrinol. 2018;258:236-243 pubmed publisher
    ..The PT-intrinsic EC system was first demonstrated in Syrian hamsters and shown to respond to photoperiodic changes...
  2. Buisson Y. [Control of Opisthorchis viverrini infection for cholangiocarcinoma prevention]. Bull Soc Pathol Exot. 2017;110:61-67 pubmed publisher
    ..viverrini is multifactorial. It has been specially studied using experimental infection on the Syrian golden hamster. Three intricated mechanisms are involved: (i) the direct damage caused by adult worms on the bile duct ..
  3. He L, Hao L, Fu X, Huang M, Li R. Severe hypertriglyceridemia and hypercholesterolemia accelerating renal injury: a novel model of type 1 diabetic hamsters induced by short-term high-fat / high-cholesterol diet and low-dose streptozotocin. BMC Nephrol. 2015;16:51 pubmed publisher
    ..Twenty-four male Golden Syrian hamsters (100-110 g) were rendered diabetes by intraperitoneal injections of streptozotocin (STZ) on consecutive 3Â..
  4. Liao C, Lin Y, Kuo C. Effect of high-fat diet on hepatic proteomics of hamsters. J Agric Food Chem. 2015;63:1869-81 pubmed publisher
    ..Fourteen nine-week old male Syrian hamsters were maintained on either control (C) or high-fat (HF) diets (0.2% cholesterol +22% fat) for 8 weeks...
  5. Singh V, Jain M, Misra A, Khanna V, Prakash P, Malasoni R, et al. Curcuma oil ameliorates insulin resistance & associated thrombotic complications in hamster & rat. Indian J Med Res. 2015;141:823-32 pubmed publisher
    ..oil in animal models of diet induced insulin resistance and associated thrombotic complications. Male Golden Syrian hamsters on high fructose diet (HFr) for 12 wk were treated orally with vehicle, fenofibrate (30 mg/kg) or C...
  6. Gowen B, Westover J, Miao J, Van Wettere A, Rigas J, Hickerson B, et al. Modeling Severe Fever with Thrombocytopenia Syndrome Virus Infection in Golden Syrian Hamsters: Importance of STAT2 in Preventing Disease and Effective Treatment with Favipiravir. J Virol. 2017;91: pubmed publisher
    ..Our findings suggest that the new SFTS model will be an excellent resource to better understand SFTSV infection and disease as well as a valuable tool for evaluating promising antiviral drugs. ..
  7. Li X, Zhao Z, Huang M, Feng R, He C, Ma C, et al. Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters. J Transl Med. 2015;13:278 pubmed publisher
    ..b>Golden hamsters were fed a high-fat diet (HFD) for 6 weeks to induce hyperlipidemia, followed by oral treatment with 50 and ..
  8. Richer L, Potula H, Melo R, Vieira A, Gomes Solecki M. Mouse model for sublethal Leptospira interrogans infection. Infect Immun. 2015;83:4693-700 pubmed publisher
    Although Leptospira can infect a wide range of mammalian species, most studies have been conducted in golden Syrian hamsters, a species particularly sensitive to acute disease...
  9. López López D, Gómez Nieto R, Herrero Turrión M, García Cairasco N, Sánchez Benito D, Ludeña M, et al. Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures. Epilepsy Behav. 2017;71:226-237 pubmed publisher
    ..As controls, intact Wistar rats and Syrian hamsters were subjected to stimulation and tissue preparation protocols identical to those performed on the ..
  10. Yang J, Chang J, Chen C, Yeh C, Chien Y. Effects of different amounts and types of dietary fatty acids on the body weight, fat accumulation, and lipid metabolism in hamsters. Nutrition. 2016;32:601-8 pubmed publisher
    ..Sixty male golden Syrian hamsters were randomly divided into six groups...
  11. Ramakrishna R, Kumar D, Bhateria M, Gaikwad A, Bhatta R. 16-Dehydropregnenolone lowers serum cholesterol by up-regulation of CYP7A1 in hyperlipidemic male hamsters. J Steroid Biochem Mol Biol. 2017;168:110-117 pubmed publisher
    ..The hypothesis was tested on golden Syrian hamsters fed with high-fat diet (HFD) following oral administration of DHP at a dose of 72mg/kg body weight for a ..
  12. da Silva A, Chieffi P, da Silva W, Kanashiro E, Rubinsky Elefant G, Cunha Neto E, et al. The hamster (Mesocricetus auratus) as an experimental model of toxocariasis: histopathological, immunohistochemical, and immunoelectron microscopic findings. Parasitol Res. 2015;114:809-21 pubmed publisher
    ..In order to characterize hamsters (Mesocricetus auratus) as a model for Toxocara canis infection, histopathological and immunohistochemistry procedures were used ..
  13. Chang C, Hsu Y, Chen Y, Huang W, Huang C, Hsu M. Effects of combined extract of cocoa, coffee, green tea and garcinia on lipid profiles, glycaemic markers and inflammatory responses in hamsters. BMC Complement Altern Med. 2015;15:269 pubmed publisher glycaemic markers and related proinflammatory cytokines by using an appropriate animal model, the golden Syrian hamster. A total of 40 male hamsters were randomly assigned to five groups: (1) vehicle control, (2) high-cholesterol ..
  14. Carnuta M, Deleanu M, Barbalata T, Toma L, Raileanu M, Sima A, et al. Zingiber officinale extract administration diminishes steroyl-CoA desaturase gene expression and activity in hyperlipidemic hamster liver by reducing the oxidative and endoplasmic reticulum stress. Phytomedicine. 2018;48:62-69 pubmed publisher
    ..Male Golden Syrian hamsters were divided in three groups: (i) fed with standard chow (N), (ii) fed with standard chow plus 3% cholesterol ..
  15. Carillon J, Romain C, Bardy G, Fouret G, Feillet Coudray C, Gaillet S, et al. Cafeteria diet induces obesity and insulin resistance associated with oxidative stress but not with inflammation: improvement by dietary supplementation with a melon superoxide dismutase. Free Radic Biol Med. 2013;65:254-261 pubmed publisher
    ..Golden Syrian hamsters received either a standard diet or a cafeteria diet composed of high-fat, high-sugar, and high-salt ..
  16. Villela N, dos Santos A, de Miranda M, Bouskela E. Fluid resuscitation therapy in endotoxemic hamsters improves survival and attenuates capillary perfusion deficits and inflammatory responses by a mechanism related to nitric oxide. J Transl Med. 2014;12:232 pubmed publisher
    ..induction by intravenous Escherichia coli lipopolysaccharide administration (2 mg x kg(-1)), male golden Syrian hamsters were fluid resuscitated and then sequentially treated with L-Nω-Nitroarginine and L-Arginine ..
  17. Eleftheriadis T, Pissas G, Liakopoulos V, Stefanidis I. Factors that May Protect the Native Hibernator Syrian Hamster Renal Tubular Epithelial Cells from Ferroptosis Due to Warm Anoxia-Reoxygenation. Biology (Basel). 2019;8: pubmed publisher
    ..cell death in mouse proximal renal tubular epithelial cells (RPTECs), whereas RPTECs of the native hibernator Syrian hamster resist cell death...
  18. Aukkanimart R, Boonmars T, Sriraj P, Songsri J, Laummaunwai P, Waraasawapati S, et al. Anthelmintic, anti-inflammatory and antioxidant effects of Garcinia mangostana extract in hamster opisthorchiasis. Exp Parasitol. 2015;154:5-13 pubmed publisher
    ..mangostana pericarp extract, in hamster opisthorchiasis. Syrian hamsters were divided into four groups: normal (control) (N); administered G...
  19. Rajasekaran D, Manoharan S, Prabhakar M, Manimaran A. Enicostemma littorale prevents tumor formation in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis. Hum Exp Toxicol. 2015;34:911-21 pubmed publisher
    ..Oral tumor was developed in the buccal pouches of male golden Syrian hamsters by painting with 0.5% DMBA three times a week for 14 weeks...
  20. Patricio Gómez J, Valdez R, Veloz A, Aguilar Vega L, Zurabian R, Romano M. The synthesis of steroids by Taenia crassiceps WFU cysticerci and tapeworms is related to the developmental stages of the parasites. Gen Comp Endocrinol. 2018;259:154-160 pubmed publisher
    ..Taenia crassiceps WFU tapeworms were recovered from the intestine of golden hamsters that had been orally infected with cysticerci...
  21. Castiglione R, Barros C, Boa B, Bouskela E. Microcirculatory effects of zinc on fructose-fed hamsters. Nutr Metab Cardiovasc Dis. 2016;26:310-7 pubmed publisher
    ..Male hamsters (Mesocricetus auratus) were fed drinking water substituted by 10% fructose solution for 60 days, whereas control animals were fed ..
  22. Yang T, Yao H, Chiang M. Red algae (Gelidium amansii) hot-water extract ameliorates lipid metabolism in hamsters fed a high-fat diet. J Food Drug Anal. 2017;25:931-938 pubmed publisher
    ..Six-week-old male Syrian hamsters were used as the experimental animals...
  23. Eberhardt E, Van den Kerkhof M, Bulté D, Mabille D, Van Bockstal L, Monnerat S, et al. Evaluation of a Pan-Leishmania Spliced-Leader RNA Detection Method in Human Blood and Experimentally Infected Syrian Golden Hamsters. J Mol Diagn. 2018;20:253-263 pubmed publisher
  24. Niculescu L, Simionescu N, Fuior E, Stancu C, Carnuta M, Dulceanu M, et al. Inhibition of miR-486 and miR-92a decreases liver and plasma cholesterol levels by modulating lipid-related genes in hyperlipidemic hamsters. Mol Biol Rep. 2018;45:497-509 pubmed publisher
    ..Male Golden-Syrian hamsters fed a hyperlipidemic (HL) diet (standard chow plus 3% cholesterol and 15% butter, 10 weeks) were injected ..
  25. Maria Del Bas J, Rodriguez B, Puiggros F, Mariné S, Rodriguez M, Moriña D, et al. Hepatic accumulation of S-adenosylmethionine in hamsters with non-alcoholic fatty liver disease associated with metabolic syndrome under selenium and vitamin E deficiency. Clin Sci (Lond). 2019;133:409-423 pubmed publisher
    ..condition, we developed a model of MetS accompanied by the onset of steatohepatitis (NASH) by challenging golden hamsters with a high-fat diet low in vitamin E and selenium (HFD), since combined deficiency results in hepatic ..
  26. Wang Y, Kayoumu A, Lu G, Xu P, Qiu X, Chen L, et al. Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis. Sci Rep. 2016;6:28014 pubmed publisher
    ..In view of the advantages in lipid metabolism features, hamster models are ideally suited for the studies of pancreatitis associated with altered metabolism in humans. ..
  27. Fazzari G, Zizza M, Di Vito A, Alo R, MELE M, Bruno R, et al. Reduced learning and memory performances in high-fat treated hamsters related to brain neurotensin receptor1 expression variations. Behav Brain Res. 2018;347:227-233 pubmed publisher
    ..e. neurotensin1 (NTR1) on mnemonic performances in the hibernating hamster (Mesocricetus auratus) exposed to a high fat diet (HFD). Interestingly, these hamsters exhibited a notable enhanced (p < 0...
  28. Fischer K, Tkach V, Curtis K, Fischer P. Ultrastructure and localization of Neorickettsia in adult digenean trematodes provides novel insights into helminth-endobacteria interaction. Parasit Vectors. 2017;10:177 pubmed publisher
    ..We used a Neorickettsia-infected strain of the model trematode Plagiorchis elegans to infect Syrian Golden hamsters to produce adult worms...
  29. Skalnik D, Simoni R. The nucleotide sequence of Syrian hamster HMG-CoA reductase cDNA. DNA. 1985;4:439-44 pubmed
    We have determined the nucleotide sequence of Syrian hamster 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase cDNA...
  30. McNally E, Bonnemann C, Kunkel L, Bhattacharya S. Deficiency of adhalin in a patient with muscular dystrophy and cardiomyopathy. N Engl J Med. 1996;334:1610-1 pubmed
  31. Pai J, Brown M, Goldstein J. Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins. Proc Natl Acad Sci U S A. 1996;93:5437-42 pubmed
    ..The current data lend further support to the notion that SREBPs are cleaved and activated as part of the program in programmed cell death...
  32. Roosa K, Place N. Mate preference for dominant vs. subordinate males in young female Syrian hamsters (Mesocricetus auratus) following chemically-accelerated ovarian follicle depletion. Physiol Behav. 2015;152:41-6 pubmed publisher
    ..We previously demonstrated this phenomenon in Syrian hamsters (Mesocricetus auratus), in that older females showed reduced preference for dominant over subordinate males...
  33. Gi M, Fujioka M, Yamano S, Shimomura E, Kanki M, Kawachi S, et al. Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters. J Toxicol Sci. 2015;40:647-56 pubmed publisher
  34. Ghose C, Eugenis I, Edwards A, Sun X, McBride S, Ho D. Immunogenicity and protective efficacy of Clostridium difficile spore proteins. Anaerobe. 2016;37:85-95 pubmed publisher
    ..difficile 630Δerm in golden Syrian hamsters. This unprecedented study shows the vaccination potential of C. difficile spore exosporium proteins.
  35. Bird B, Shrivastava Ranjan P, Dodd K, Erickson B, Spiropoulou C. Effect of Vandetanib on Andes virus survival in the hamster model of Hantavirus pulmonary syndrome. Antiviral Res. 2016;132:66-9 pubmed publisher
    ..Here we investigate the impact of a small molecule antagonist of the VEGF receptor 2 (VEGFR-2) activation in vitro, and overall impact on survival in the Syrian hamster model of HPS.
  36. Zhao M, Wang S, Jiang Y, Wang Y, Shen H, Xu P, et al. Hypolipidemic effect of XH601 on hamsters of Hyperlipidemia and its potential mechanism. Lipids Health Dis. 2017;16:85 pubmed publisher
    ..The present study was to investigate the hypolipidemia effect and potential mechanism of XH601. Male Golden Syrian hamsters were induced by high-fat diet (HFD) for eight weeks and the hyperlipidemic model was established successfully...
  37. Theint T, Nadaud P, Aucoin D, Helmus J, Pondaven S, Surewicz K, et al. Species-dependent structural polymorphism of Y145Stop prion protein amyloid revealed by solid-state NMR spectroscopy. Nat Commun. 2017;8:753 pubmed publisher
    ..into the structural differences between Y145Stop prion protein amyloids from three species: human, mouse, and Syrian hamster. Remarkably, we find that these structural differences are largely controlled by only two amino acids at ..
  38. Santos J, Cervera Carrascon V, Havunen R, Zafar S, Siurala M, Sorsa S, et al. Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy. Mol Ther. 2018;26:2243-2254 pubmed publisher
    ..Human adenovirus (Ad5/3-E2F-D24-hTNF-α-IRES-hIL-2; TILT-123) replication was studied using a Syrian hamster pancreatic tumor model (HapT1) infused with tumor-infiltrating lymphocytes (TILs)...
  39. Koga N, Ariyoshi N, Nakashima H, Yoshimura H. Purification and characterization of two forms of 2,3,4,7,8-pentachlorodibenzofuran-inducible cytochrome P-450 in hamster liver. J Biochem. 1990;107:826-33 pubmed
    ..3-fold with hamster P-450L and 2.2-fold with hamster P-450H. In addition, hamster P-450H catalyzed estradiol 2-hydroxylation at a high rate but hamster P-450L did not.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  40. Shigesada K, Stark G, Maley J, Niswander L, Davidson J. Construction of a cDNA to the hamster CAD gene and its application toward defining the domain for aspartate transcarbamylase. Mol Cell Biol. 1985;5:1735-42 pubmed
    ..coli and mammalian aspartate transcarbamylases, one such difference being that the bacterial enzyme in its native form is allosterically regulated and the mammalian enzyme is not. ..
  41. Liew C, Jandreski M. Construction and characterization of the alpha form of a cardiac myosin heavy chain cDNA clone and its developmental expression in the Syrian hamster. Proc Natl Acad Sci U S A. 1986;83:3175-9 pubmed
    A cDNA clone, pVHC1, was isolated from a Syrian hamster heart cDNA library and was compared to the rat alpha (pCMHC21) and beta (pCMHC5) ventricular myosin heavy chain cDNA clones...
  42. Bergstrom C, Wagner C, Ann D, Hanna P. Hamster monomorphic arylamine N-acetyltransferase: expression in Escherichia coli and purification. Protein Expr Purif. 1995;6:45-55 pubmed
    ..Enzyme purified to homogeneity by immunoaffinity chromatography exhibited substrate specificity comparable to that of the hamster-derived protein. ..
  43. Errami A, Smider V, Rathmell W, He D, Hendrickson E, Zdzienicka M, et al. Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants. Mol Cell Biol. 1996;16:1519-26 pubmed
  44. Shevchenko A, Keller P, Scheiffele P, Mann M, Simons K. Identification of components of trans-Golgi network-derived transport vesicles and detergent-insoluble complexes by nanoelectrospray tandem mass spectrometry. Electrophoresis. 1997;18:2591-600 pubmed publisher
    ..With these approaches and with the previously published data we have now identified most of the major low molecular weight proteins recovered in detergent-insoluble glycolipid-enriched complexes...
  45. Fukumura J, Noguchi E, Sekiguchi T, Nishimoto T. A temperature-sensitive mutant of the mammalian RNA helicase, DEAD-BOX X isoform, DBX, defective in the transition from G1 to S phase. J Biochem. 2003;134:71-82 pubmed
    ..5 degrees C for 17 h. The amount of cyclin A mRNA decreased in ts ET24 cells within 4 h after the temperature shift to 39.5 degrees C, consistent with the fact that the entry into the S-phase was delayed by the temperature shift...
  46. Slominski A, Pisarchik A, Tobin D, Mazurkiewicz J, Wortsman J. Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology. 2004;145:941-50 pubmed publisher
    ..The adnexal location of CRH-R2 suggests a role for the receptor in hair growth. The differential interspecies CRH signaling expression pattern probably reflects adaptation to species-specific skin function determinants...
  47. Akita K, Hanaya T, Arai S, Ohta T, Okamoto I, Fukuda S. Purification, identification, characterization, and cDNA cloning of a high molecular weight extracellular superoxide dismutase of hamster that transiently increases in plasma during arousal from hibernation. Comp Biochem Physiol A Mol Integr Physiol. 2007;146:223-32 pubmed
    We previously studied antioxidant profiles in the plasma of hibernating Syrian hamsters and found a transient increase of a superoxide radical-scavenging activity during the arousal phase...
  48. Wang B, Heath Engel H, Zhang D, Nguyen N, Thomas D, Hanrahan J, et al. BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex. Cell. 2008;133:1080-92 pubmed publisher
    ..Thus, BAP31 operates at early steps to deliver newly synthesized CFTRDeltaF508 to its degradation pathway...
  49. Manoogian E, Leise T, Bittman E. Phase resetting in duper hamsters: specificity to photic zeitgebers and circadian phase. J Biol Rhythms. 2015;30:129-43 pubmed publisher
    The duper mutation in Syrian hamsters shortens the free-running period of locomotor activity (Ï„DD) to about 23 h and results in a type 0 phase-response curve (PRC) to 15-min light pulses...
  50. Shannonhouse J, Grater D, York D, Wellman P, Morgan C. Sex differences in motivational responses to dietary fat in Syrian hamsters. Physiol Behav. 2015;147:102-16 pubmed publisher
    ..Moreover, the results validate a new assay for chronic antidepressant efficacy. ..
  51. d Ovidio D, Noviello E, Pepe P, Del Prete L, Cringoli G, Rinaldi L. Survey of Hymenolepis spp. in pet rodents in Italy. Parasitol Res. 2015;114:4381-4 pubmed publisher
    ..striatus, Tamias sibiricus, Sciurus calorinensis; n = 52), hamsters (Phodopus campbelli, Mesocricetus auratus; n = 30), chinchillas (Chinchilla lanigera; n = 13), rats (Rattus norvegicus; n..
  52. Kim J, Auffinger B, Spencer D, Miska J, Chang A, Kane J, et al. Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters. J Transl Med. 2016;14:134 pubmed publisher
    ..evaluated the toxicity and biodistribution of CRAd-S-pk7 administered as a single intracerebral dose to Syrian hamsters, a permissive model of adenoviral replication...
  53. De Lorme K, Sisk C. The organizational effects of pubertal testosterone on sexual proficiency in adult male Syrian hamsters. Physiol Behav. 2016;165:273-7 pubmed publisher
    ..These results support the hypothesis that pubertal testosterone organizes neural circuits underlying behavioral flexibility and adaptability to promote sexual proficiency in adulthood. ..
  54. Kong F, Saldarriaga O, Spratt H, Osorio E, Travi B, Luxon B, et al. Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype. PLoS Pathog. 2017;13:e1006165 pubmed publisher
    ..In previous studies, we used the Syrian hamster (Mesocricetus auratus) as a model because it mimics the progressive nature of active human VL...
  55. Trefna M, Goris M, Thissen C, Reitsema V, Bruintjes J, de Vrij E, et al. The influence of sex and diet on the characteristics of hibernation in Syrian hamsters. J Comp Physiol B. 2017;187:725-734 pubmed publisher
    ..An exception is Syrian hamster (Mesocricetus auratus), the only standard laboratory animal showing deep hibernation...
  56. Bermejo Millo J, Guimarães M, de Luxán Delgado B, Potes Y, Pérez Martínez Z, Díaz Luis A, et al. High-Fructose Consumption Impairs the Redox System and Protein Quality Control in the Brain of Syrian Hamsters: Therapeutic Effects of Melatonin. Mol Neurobiol. 2018;55:7973-7986 pubmed publisher oxidative stress and protein quality control systems induced by a high-fructose diet in the brain of Syrian hamsters and their possible attenuation by exogenous melatonin...
  57. Kiefer M, Stephans J, Crawford K, Okino K, Barr P. Ligand-affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor. Proc Natl Acad Sci U S A. 1990;87:6985-9 pubmed
    ..In addition to binding basic FGF, this protein or related surface proteins may function as an initial cellular attachment site for other growth factors and for viruses, such as herpes simplex virus. ..
  58. Crosby C, Matchett W, Anguiano Zarate S, Parks C, Weaver E, Pease L, et al. Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses. J Virol. 2017;91: pubmed publisher
    ..expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors in Syrian hamsters and rhesus macaques...
  59. Dowton S, Holden S. C-reactive protein (CRP) of the Syrian hamster. Biochemistry. 1991;30:9531-8 pubmed
    Complementary and genomic clones encoding the mRNA and gene for a protein in the Syrian hamster that is highly homologous to C-reactive protein (CRP) have been isolated and studied...
  60. Roberds S, Campbell K. Adhalin mRNA and cDNA sequence are normal in the cardiomyopathic hamster. FEBS Lett. 1995;364:245-9 pubmed
    ..6 hamster cardiac muscle, and no mutation in adhalin coding sequence was found, indicating that the inherited myopathy and cardiomyopathy of the BIO 14.6 hamster are most likely not due to mutations in the adhalin gene. ..
  61. Pickles J, Pant K, Mcginty L, Yasaei H, Roberts T, Scott A, et al. A mechanistic evaluation of the Syrian hamster embryo cell transformation assay (pH 6.7) and molecular events leading to senescence bypass in SHE cells. Mutat Res Genet Toxicol Environ Mutagen. 2016;802:50-8 pubmed publisher
    The implementation of the Syrian hamster embryo cell transformation assay (SHE CTA) into test batteries and its relevance in predicting carcinogenicity has been long debated...
  62. Zaid K, Nhar B, Ghadeer Alanazi S, Murad R, Domani A, Alhafi A. Lack of Effects of Recombinant Human Bone Morphogenetic Protein2 on Angiogenesis in Oral Squamous Cell Carcinoma Induced in the Syrian hamster Cheek Pouch. Asian Pac J Cancer Prev. 2016;17:3527-31 pubmed
    ..OSCC, a biologic process critical for tumor formation in an experimental model in the buccal pouch of golden Syrian hamsters. Buccal cavities were exposed to painting with 0...
  63. Boa B, Souza M, Leite R, da Silva S, Barja Fidalgo T, Kraemer Aguiar L, et al. Chronic aerobic exercise associated to dietary modification improve endothelial function and eNOS expression in high fat fed hamsters. PLoS ONE. 2014;9:e102554 pubmed publisher
    ..Our results indicate that an aerobic routine and/or dietary modification may cause significant improvements to high fat fed animals, diminishing visceral depots, increasing eNOS expression and reducing microcirculatory dysfunction. ..
  64. Fan Z, Meng Q, Bunch T, White K, Wang Z. Effective cryopreservation of golden Syrian hamster embryos by open pulled straw vitrification. Lab Anim. 2016;50:45-53 pubmed publisher
    Golden Syrian hamster embryos are difficult to cryopreserve due to their high sensitivity to cryoprotectants and in vitro handling...
  65. Caridha D, Parriot S, Hudson T, Lang T, Ngundam F, Leed S, et al. Use of Optical Imaging Technology in the Validation of a New, Rapid, Cost-Effective Drug Screen as Part of a Tiered In Vivo Screening Paradigm for Development of Drugs To Treat Cutaneous Leishmaniasis. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..reduction in the bioluminescence signal compared to that in control animals can be tested in lower-throughput, more definitive tests of lesion cure in BALB/c mice and Golden Syrian hamsters (GSH) using Old World and New World parasites.
  66. Bell G, Sanchez Pescador R. Sequence of a cDNA encoding Syrian hamster preproinsulin. Diabetes. 1984;33:297-300 pubmed
    A complementary DNA (cDNA) library was prepared from messenger RNA (mRNA) isolated from Syrian hamster islets...
  67. Ramos L, Chávez B, Vilchis F. Cloning and differential expression of steroid 5 alpha-reductase type 1 (Srd5a1) and type 2 (Srd5a2) from the Harderian glands of hamsters. Gen Comp Endocrinol. 2010;166:388-95 pubmed publisher
    ..The biochemical characteristics and relative expression of these 5 alpha-reductases support the view that both isozymes may play a relevant role in modulating androgen signaling in HG. ..
  68. van Doremalen N, Munster V. Animal models of Middle East respiratory syndrome coronavirus infection. Antiviral Res. 2015;122:28-38 pubmed publisher
    ..Commonly used laboratory animal species such as Syrian hamsters, mice and ferrets are not susceptible to MERS-CoV, due to differences in the MERS-CoV receptor dipeptidyl ..
  69. Iwatsuki Horimoto K, Nakajima N, Ichiko Y, Sakai Tagawa Y, Noda T, Hasegawa H, et al. Syrian Hamster as an Animal Model for the Study of Human Influenza Virus Infection. J Virol. 2018;92: pubmed publisher
    ..In this study, we investigated the susceptibility of Syrian hamsters to influenza viruses with a view to using the hamster model as an alternative to the mouse model...
  70. Aharony D, Little J, Thomas C, Powell S, Berry D, Graham A. Isolation and pharmacological characterization of a hamster urinary bladder neurokinin A receptor cDNA. Mol Pharmacol. 1994;45:9-19 pubmed
    ..The rank order of antagonist affinity is consistent with the observations of NK-2 receptor pharmacology in the native tissues. ..
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    ..Finally, inspection of the Asibi strain E protein structure combined to in vivo testing revealed the importance of an exposed α-helix in domain I, containing residues 154 and 155, for Ap7M virulence in hamsters. ..
  72. Deacon R. Burrowing: a sensitive behavioural assay, tested in five species of laboratory rodents. Behav Brain Res. 2009;200:128-33 pubmed
    ..g. be useful in detecting scrapie infection in hamsters (Mesocricetus auratus), a commonly used species in prion disease research...
  73. Ross A, Norvelle A, Choi D, Walton J, Albers H, Huhman K. Social housing and social isolation: Impact on stress indices and energy balance in male and female Syrian hamsters (Mesocricetus auratus). Physiol Behav. 2017;177:264-269 pubmed publisher
    Although Syrian hamsters are thought to be naturally solitary, recent evidence from our laboratory demonstrates that hamsters may actually prefer social contact...
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  75. Rafaeloff R, Pittenger G, Barlow S, Qin X, Yan B, Rosenberg L, et al. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest. 1997;99:2100-9 pubmed publisher
  76. Sakamoto A, Ono K, Abe M, Jasmin G, Eki T, Murakami Y, et al. Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene, delta-sarcoglycan, in hamster: an animal model of disrupted dystrophin-associated glycoprotein complex. Proc Natl Acad Sci U S A. 1997;94:13873-8 pubmed
    ..The present study not only identifies CM hamster as a valuable animal model for studying the function of delta-SG in vivo but also provides a genetic target for diagnosis and treatment of human CM...
  77. Zhang L, Zong C, Ichihara S, Naito H, Toyokuni S, Kumagai S, et al. A trial to find appropriate animal models of dichloropropane-induced cholangiocarcinoma based on the hepatic distribution of glutathione S-transferases. J Occup Health. 2015;57:548-54 pubmed publisher
    ..First, 12 each of C57BL/6J mice, Balb/cA mice, F344 rats, Syrian hamsters, and guinea pigs were divided into four equal groups and exposed to DCP at 0, 300, 1,000, or 3,000 ppm 8 ..
  78. El Ansary A, Bacha A, Bjørklund G, Al Orf N, Bhat R, Moubayed N, et al. Probiotic treatment reduces the autistic-like excitation/inhibition imbalance in juvenile hamsters induced by orally administered propionic acid and clindamycin. Metab Brain Dis. 2018;33:1155-1164 pubmed publisher
    ..Fifty young golden Syrian hamsters weighing between 60 and 70 g were enrolled in the study...
  79. Gervais C, Suh M. Serum amyloid A protein-related mRNA expression in herpes simplex virus type 2-transformed hamster cells. Mol Cell Biol. 1990;10:4412-4 pubmed
    ..Higher rates of nuclear runoff transcription in transformed and induced cells indicated some regulation at the transcriptional level. ..
  80. Gekakis N, Staknis D, Nguyen H, Davis F, Wilsbacher L, King D, et al. Role of the CLOCK protein in the mammalian circadian mechanism. Science. 1998;280:1564-9 pubmed
    ..Thus, CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity...
  81. Mirmira R, Watada H, German M. Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains. J Biol Chem. 2000;275:14743-51 pubmed
    ..Our findings suggest a model in which Nkx6.1, regulated by interactions through its carboxyl terminus, directs the repression of specific genes in developing and mature beta-cells...
  82. Wang J, Yu L, Wang H, Gao Y, Schrementi J, Porter R, et al. Identification and characterization of hamster stearoyl-CoA desaturase isoforms. Lipids. 2008;43:197-205 pubmed publisher
    ..Here we report the identification of cDNA sequences corresponding to SCD1, SCD2 and SCD3 of golden hamster. The deduced amino acid sequences of these hamster SCD (hmSCD) isoforms display a high degree of homologies to ..
  83. Ness G. Physiological feedback regulation of cholesterol biosynthesis: Role of translational control of hepatic HMG-CoA reductase and possible involvement of oxylanosterols. Biochim Biophys Acta. 2015;1851:667-73 pubmed publisher
    ..In animals that are sensitive to dietary cholesterol such as Golden Syrian hamsters, feedback regulation occurs mainly at the level of transcription of hepatic HMG-CoA reductase (3-hydroxy-3-..
  84. Yoshimi T, Takahashi Y, Takahashi S, Miura T. Changes in lung-specific molecular expression during differentiation of hamster embryonic M3E3/C3 cell line. Biochem Cell Biol. 2000;78:659-66 pubmed
    ..The present study confirms that at the gene transcription level M3E3/C3 cells differentiate into Clara-like cells with mucus granules in the presence of retinol...
  85. He K, Ye X, Wu H, Wang Y, Zou Z, Ning N, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015;50:185-94 pubmed publisher
    ..was conducted to evaluate the cholesterol-lowering effect of coptisine extracted from Rhizoma coptidis in Syrian golden hamsters. The safety results indicated that coptisine was a safe and low-toxic compound...
  86. Fan W, Trifiletti R, Cooper T, Norris J. Cloning of a mu-class glutathione S-transferase gene and identification of the glucocorticoid regulatory domains in its 5' flanking sequence. Proc Natl Acad Sci U S A. 1992;89:6104-8 pubmed
  87. Schöttner K, Vuillez P, Challet E, Pévet P, Weinert D. Light-induced c-Fos expression in the SCN and behavioural phase shifts of Djungarian hamsters with a delayed activity onset. Chronobiol Int. 2015;32:596-607 pubmed publisher
  88. Liu X, Ma S, Turino G, Cantor J. The Pattern of Elastic Fiber Breakdown in Bleomycin-Induced Pulmonary Fibrosis May Reflect Microarchitectural Changes. Lung. 2017;195:93-99 pubmed publisher
    ..b>Syrian hamsters were instilled intratracheally with 1.0 unit BLM in 0...
  89. Secore S, Wang S, Doughtry J, Xie J, Miezeiewski M, Rustandi R, et al. Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains. PLoS ONE. 2017;12:e0170640 pubmed publisher
    ..We demonstrate, using the Syrian golden hamster model of CDI, that the inclusion of binary toxin components CDTa and CDTb significantly improves the ..
  90. Jennings K, Chasles M, Cho H, Mikkelsen J, Bentley G, Keller M, et al. The Preoptic Area and the RFamide-Related Peptide Neuronal System Gate Seasonal Changes in Chemosensory Processing. Integr Comp Biol. 2017;57:1055-1065 pubmed publisher
    Males of many species rely on chemosensory information for social communication. In male Syrian hamsters (Mesocricetus auratus), as in many species, female chemosignals potently stimulate sexual behavior and a concurrent, rapid increase ..
  91. Biswas S, Kalil K. The Microtubule-Associated Protein Tau Mediates the Organization of Microtubules and Their Dynamic Exploration of Actin-Rich Lamellipodia and Filopodia of Cortical Growth Cones. J Neurosci. 2018;38:291-307 pubmed publisher
    ..We used cultures of cortical neurons from postnatal day (P)0-P2 golden Syrian hamsters (Mesocricetus auratus) of either sex to study the role of tau in the organization and dynamics of the axonal growth cone ..
  92. Cloutier M, Fleury A, Courtemanche J, Ducharme L, Mason J, LeHoux J. Cloning and expression of hamster adrenal cytochrome P450C17 cDNA. Ann N Y Acad Sci. 1995;774:294-6 pubmed