Domestic guinea pig

Summary

Alias: guinea pig, Cavia porcellus, Cavia aperea porcellus, Cavia cobaya, Cavia cobya

Top Publications

  1. Hanner M, Moebius F, Flandorfer A, Knaus H, Striessnig J, Kempner E, et al. Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci U S A. 1996;93:8072-7 pubmed
    ..We purified the sigma1-binding site as a single 30-kDa protein from guinea pig liver employing the benzomorphan(+)[3H]pentazocine and the arylazide (-)[3H]azidopamil as specific probes...
  2. Yamamoto H, Miura R, Yamamoto T, Shinohara K, Watanabe M, Okuyama S, et al. Amino acid residues in the transmembrane domain of the type 1 sigma receptor critical for ligand binding. FEBS Lett. 1999;445:19-22 pubmed
    ..By contrast, ligand binding was significantly suppressed by the substitutions. These findings provide evidence that the transmembrane domain of the type 1 sigma receptor plays a critical role in ligand binding of this receptor. ..
  3. Dascher C, Hiromatsu K, Naylor J, Brauer P, Brown K, Storey J, et al. Conservation of a CD1 multigene family in the guinea pig. J Immunol. 1999;163:5478-88 pubmed
    ..Here we describe the CD1 gene family of the guinea pig (Cavia porcellus)...
  4. Welsh T, Mitchell C, Walters W, Mesiano S, Zakar T. Prostaglandin H2 synthase-1 and -2 expression in guinea pig gestational tissues during late pregnancy and parturition. J Physiol. 2005;569:903-12 pubmed
    ..The induction of PTGS1 in the amnion and the PYS is a critical event leading to labour in guinea pigs and models analogous changes in the human gestational tissues before labour. ..
  5. Pal A, FONTANILLA D, Gopalakrishnan A, Chae Y, Markley J, Ruoho A. The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements. Eur J Pharmacol. 2012;682:12-20 pubmed publisher
    ..These novel functions of the sigma-1 receptor were sensitive to well-known sigma ligands via their antagonist/agonist properties. ..
  6. Bell T, Bunton T, Shaia C, Raymond J, Honnold S, Donnelly G, et al. Pathogenesis of Bolivian Hemorrhagic Fever in Guinea Pigs. Vet Pathol. 2016;53:190-9 pubmed publisher
    ..Guinea pigs (Cavia porcellus) were serially sampled to evaluate the temporal progression of infection, gross and histologic lesions, and ..
  7. Wan Y, Kang G, Sreenivasan C, Daharsh L, Zhang J, Fan W, et al. A DNA Vaccine Expressing Consensus Hemagglutinin-Esterase Fusion Protein Protected Guinea Pigs from Infection by Two Lineages of Influenza D Virus. J Virol. 2018;92: pubmed publisher
    ..consensus IDV HEF DNA vaccine can elicit complete protection against infection from two lineages of IDV in the guinea pig model...
  8. Barboza L, Lezirovitz K, Zanatta D, Strauss B, Mingroni Netto R, Oiticica J, et al. Transplantation and survival of mouse inner ear progenitor/stem cells in the organ of Corti after cochleostomy of hearing-impaired guinea pigs: preliminary results. Braz J Med Biol Res. 2016;49:e5064 pubmed publisher
    ..We also examined the effects of mIESC transplantation on auditory functions. Eight adult female Cavia porcellus guinea pigs (250-350 g) were deafened by intratympanic neomycin delivery...
  9. Fu L, Hou Y, Ding X, Du Y, Zhu H, Zhang N, et al. Molecular cloning, overexpression, purification, and sequence analysis of the giant panda (Ailuropoda melanoleuca) ferritin light polypeptide. Genet Mol Res. 2016;15: pubmed publisher
    ..and deduced amino acid sequences are highly conserved across several mammals, including Homo sapiens, Cavia porcellus, Equus caballus, and Felis catus, among others. The FTL gene was readily expressed in E...

More Information

Publications699 found, 100 shown here

  1. Rodríguez Lázaro D, Ariza Miguel J, Diez Valcarce M, Fernández Natal I, Hernández M, Rovira J. Foods confiscated from non-EU flights as a neglected route of potential methicillin-resistant Staphylococcus aureus transmission. Int J Food Microbiol. 2015;209:29-33 pubmed publisher
    ..One hundred and seventeen meat samples of diverse animal origin (including antelope, beef, chicken, duck, guinea pig, pork, rodents, and turkey), 75 dairy products (74 cheeses and 1 butter) and 3 eggs were analyzed. All S...
  2. Stavely R, Robinson A, Miller S, Boyd R, Sakkal S, Nurgali K. Human adult stem cells derived from adipose tissue and bone marrow attenuate enteric neuropathy in the guinea-pig model of acute colitis. Stem Cell Res Ther. 2015;6:244 pubmed publisher
    ..However, BM-MSCs were more therapeutic in the treatment of enteric neuropathy and plexitis. These characteristics should be considered when deciding on the MSC tissue source. ..
  3. Frohwein T, Sonnenburg A, Zuberbier T, Stahlmann R, Schreiner M. Unsaturated compounds induce up-regulation of CD86 on dendritic cells in the in vitro sensitization assay LCSA. Arch Toxicol. 2016;90:927-36 pubmed publisher
    ..compounds are known to cause false-positive reactions in the local lymph node assay (LLNA) but not in the guinea pig maximization test...
  4. Heinrich U, Strieth S, Schmidtmann I, Li H, Helling K. Gentamicin alters Akt-expression and its activation in the guinea pig cochlea. Neuroscience. 2015;311:490-8 pubmed publisher
    ..The increase in Akt- and p-Akt-expression in the organ of Corti and spiral ganglion cells indicates a selected response of the cochlea against gentamicin toxicity. ..
  5. Fukuta H, Mitsui R, Takano H, Hashitani H. Contractile properties of periosteal arterioles in the guinea-pig tibia. Pflugers Arch. 2017;469:1203-1213 pubmed publisher
    ..Thus, the enhanced endothelial NO release in adult guinea-pigs may be important to increase the blood supply to meet the increased metabolic demands during bone growth. ..
  6. Mitobe J, Sinha R, Mitra S, Nag D, Saito N, Shimuta K, et al. An attenuated Shigella mutant lacking the RNA-binding protein Hfq provides cross-protection against Shigella strains of broad serotype. PLoS Negl Trop Dis. 2017;11:e0005728 pubmed publisher
    ..Thus, the vaccine potential of this mutant was tested in two guinea pig models of shigellosis...
  7. Robinson P, Liu X, Sparrow A, Patel S, Zhang Y, Casadei B, et al. Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling. J Biol Chem. 2018;293:10487-10499 pubmed publisher
    ..variants of human troponin-T, troponin-I, and ?-tropomyosin (R92Q, R145G, and D175N, respectively) in isolated guinea pig left ventricular cardiomyocytes...
  8. Scott J, Gabrielides C, Davidson R, Swingler T, Clark I, Wallis G, et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Ann Rheum Dis. 2010;69:1502-10 pubmed publisher
    ..SOD2 expression in Dunkin-Hartley guinea pig knee articular cartilage was determined by immunohistochemistry...
  9. Wang S, Zhao Y, Zhang J, Huang X, Wang Y, Xu X, et al. Antidiarrheal effect of Alpinia oxyphylla Miq. (Zingiberaceae) in experimental mice and its possible mechanism of action. J Ethnopharmacol. 2015;168:182-90 pubmed publisher
    ..In vitro spontaneous contractions of the isolated guinea pig ileum induced by carbachol, neostigmine and histamine were attenuated by both the extract and elution...
  10. Baumann A, Skaljac M, Lehmann R, Vilcinskas A, Franta Z. Urate Oxidase produced by Lucilia sericata medical maggots is localized in Malpighian tubes and facilitates allantoin production. Insect Biochem Mol Biol. 2017;83:44-53 pubmed publisher
    ..used quantitative RT-PCR and RNA in situ hybridization to monitor the expression of the UO gene, and we used a guinea pig anti-UO antibody to detect the native enzyme by western blot and by florescence immunohistochemistry in larval ..
  11. Kumar A, Yogisharadhya R, Venkatesan G, Bhanuprakash V, Shivachandra S. Immunogenicity and protective efficacy of recombinant major envelope protein (rH3L) of buffalopox virus in animal models. Antiviral Res. 2016;126:108-16 pubmed publisher
    ..The purified rH3L protein was further used for active immunization of guinea pig (250 μg/dose) and adult mice (10 μg and 50 μg/dose) with or without adjuvants (alum, Freund's Complete ..
  12. Dobson C, Thevasundaram K, Mongillo D, Winterborn A, Holloway A, Brien J, et al. Chronic prenatal ethanol exposure alters expression of central and peripheral insulin signaling molecules in adult guinea pig offspring. Alcohol. 2014;48:687-93 pubmed publisher
    ..that CPEE alters expression of insulin and IGF signaling molecules in the prefrontal cortex and liver of adult guinea pig offspring...
  13. Gajos Draus A, Duda M, Beresewicz A. Cardiac and renal upregulation of Nox2 and NF-?B and repression of Nox4 and Nrf2 in season- and diabetes-mediated models of vascular oxidative stress in guinea-pig and rat. Physiol Rep. 2017;5: pubmed publisher
  14. Coscas R, Dupont S, Mussot S, Louedec L, Etienne H, Morvan M, et al. Exploring antibody-dependent adaptive immunity against aortic extracellular matrix components in experimental aortic aneurysms. J Vasc Surg. 2018;: pubmed publisher
    ..In the ECM group (n = 20), rats were presensitized against the guinea pig aortic ECM before implantation of a decellularized aortic xenograft (DAX)...
  15. Maléth J, Balázs A, Pallagi P, Balla Z, Kui B, Katona M, et al. Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis. Gastroenterology. 2015;148:427-39.e16 pubmed publisher
    ..Based on studies of human, mouse, and guinea pig pancreata, alcohol disrupts expression and localization of the CFTR...
  16. Ngoula F, Guemdjo Tekam M, Kenfack A, Tadondjou Tchingo C, Nouboudem S, Ngoumtsop H, et al. Effects of heat stress on some reproductive parameters of male cavie (Cavia porcellus) and mitigation strategies using guava (Psidium guajava) leaves essential oil. J Therm Biol. 2017;64:67-72 pubmed publisher
    ..These effects that can be mitigated by the administration of guava leaves essential oil. ..
  17. Reiss L, Stark G, Nguyen Huynh A, Spear K, Zhang H, Tanaka C, et al. Morphological correlates of hearing loss after cochlear implantation and electro-acoustic stimulation in a hearing-impaired Guinea pig model. Hear Res. 2015;327:163-74 pubmed publisher
    ..Further research is needed to separate these potential mechanisms of delayed hearing loss. ..
  18. Fujita T, Yamashita D, Irino Y, Kitamoto J, Fukuda Y, Inokuchi G, et al. Metabolomic profiling in inner ear fluid by gas chromatography/mass spectrometry in guinea pig cochlea. Neurosci Lett. 2015;606:188-93 pubmed publisher
    ..The purpose of this study was to perform metabolomic analysis of the inner ear fluid in guinea pig cochlea, which has not been previously reported in literature, using gas chromatography/mass spectrometry (GC/MS)..
  19. Abuelezz S. Nebivolol attenuates oxidative stress and inflammation in a guinea pig model of ovalbumin-induced asthma: a possible mechanism for its favorable respiratory effects. Can J Physiol Pharmacol. 2018;96:258-265 pubmed publisher
    ..Collectively, these results suggest a beneficial effect of nebivolol in asthma. ..
  20. Tsai C, Lee M, Tey S, Liu C, Huang S. Mechanism of resveratrol-induced relaxation in the human gallbladder. BMC Complement Altern Med. 2017;17:254 pubmed publisher
    ..Although resveratrol has been reported to cause relaxation of the guinea pig gallbladder, limited data are available about the effect of resveratrol on the gallbladder smooth muscle in ..
  21. Yocum G, Chen J, Choi C, Townsend E, Zhang Y, Xu D, et al. Role of transient receptor potential vanilloid 1 in the modulation of airway smooth muscle tone and calcium handling. Am J Physiol Lung Cell Mol Physiol. 2017;312:L812-L821 pubmed publisher
    ..In guinea pig tracheal ring organ bath experiments, the TRPV1 agonist capsaicin led to ASM contraction, but this contraction ..
  22. Dbeibo L, van Rensburg J, Smith S, Fortney K, Gangaiah D, Gao H, et al. Evaluation of CpxRA as a Therapeutic Target for Uropathogenic Escherichia coli Infections. Infect Immun. 2018;86: pubmed publisher
    ..including the fim and pap operons, and it exhibited reduced mannose-sensitive hemagglutination of guinea pig red blood cells in vitro In competition experiments with mice, both mutants were less fit than the parent ..
  23. Álvarez Santos M, Carbajal V, Tellez Jiménez O, Martínez Cordero E, Ruiz V, Hernández Pando R, et al. Airway Hyperresponsiveness in Asthma Model Occurs Independently of Secretion of β1 Integrins in Airway Wall and Focal Adhesions Proteins Down Regulation. J Cell Biochem. 2016;117:2385-96 pubmed publisher
    ..A similar phenomenon occurs with β1 integrins (α1β1 and α2β1) in guinea pig. The putative role of β1 integrin subunit alterations due to shedding in airway smooth muscle (ASM) in an ..
  24. Gründel A, Friedrich K, Pfeiffer M, Jacobs E, Dumke R. Subunits of the Pyruvate Dehydrogenase Cluster of Mycoplasma pneumoniae Are Surface-Displayed Proteins that Bind and Activate Human Plasminogen. PLoS ONE. 2015;10:e0126600 pubmed publisher
    ..pneumoniae. Subunits of PDH were cloned, expressed and purified to produce specific polyclonal guinea pig antisera...
  25. Bennett G, Palliser H, Shaw J, Walker D, Hirst J. Prenatal Stress Alters Hippocampal Neuroglia and Increases Anxiety in Childhood. Dev Neurosci. 2015;37:533-45 pubmed publisher
    ..parameters, adrenocortical responses to handling and possible neurosteroid influences towards outcomes in guinea pig offspring in childhood. Pregnant guinea pig dams were exposed to strobe light for 2 h (9-11 a.m...
  26. Schmitz S, Tacke S, Guth B, Henke J. Repeated anaesthesia with isoflurane and medetomidine-midazolam-fentanyl in guinea pigs and its influence on physiological parameters. PLoS ONE. 2017;12:e0174423 pubmed publisher
    ..and in daily veterinary practice, but anaesthesia is known to alter physiological parameters in GPs (Cavia porcellus, GPs)...
  27. Shao J, Liu X, Ly H, Liang Y. Characterization of the Glycoprotein Stable Signal Peptide in Mediating Pichinde Virus Replication and Virulence. J Virol. 2016;90:10390-10397 pubmed
    ..of alanine substitutions at many conserved residues within the SSP on viral replication in cell culture and in a guinea pig infection model...
  28. Kocic I, Hirano Y, Hiraoka M. Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes. J Pharmacol Sci. 2004;95:189-95 pubmed
    ..The whole cell configuration of the patch-clamp technique was applied to guinea pig ventricular myocytes exposed to isotonic and hypotonic solutions...
  29. Verrier R, Bonatti R, Silva A, Batatinha J, Nearing B, Liu G, et al. If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation. Heart Rhythm. 2014;11:2288-96 pubmed publisher
    ..1 mg/kg i.v. bolus) were studied in an anesthetized Yorkshire pig (N = 7) model of AF and in isolated guinea pig hearts (N = 7). Ivabradine reduced heart rate (P = ...
  30. Ruark C, Chapleau R, Mahle D, Gearhart J. Organophosphorus Inhibition and Characterization of Recombinant Guinea Pig Acetylcholinesterase. Protein Pept Lett. 2015;22:862-8 pubmed
    ..Historically, the guinea pig has been believed to be the best non-primate model for OP toxicology and medical countermeasure development ..
  31. Odegard J, Flynn P, Campbell D, Robbins S, Dong L, Wang K, et al. A novel HSV-2 subunit vaccine induces GLA-dependent CD4 and CD8 T cell responses and protective immunity in mice and guinea pigs. Vaccine. 2016;34:101-9 pubmed publisher
    ..In the guinea pig model of recurrent HSV-2 infection, therapeutic immunization with G103 was approximately 50% effective in ..
  32. Fang B, Shen J, Zhang H, Zhou S, Lyu C, Xie Y. Albiflorin Granule significantly decreased the cholesterol gallstone formation by the regulation of insulin transduction signal. Asian Pac J Trop Med. 2016;9:877-881 pubmed publisher
    ..protein in the GS group increased significantly and Albiflorin could reduce IKK-β protein expression in guinea pig liver cells...
  33. Chen J, Ko W. Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. Eur J Pharmacol. 2017;811:129-133 pubmed publisher
    ..In conclusion, the relaxant effect of apigenin may be due to inhibition of both enzyme activities and reduction of intracellular Ca2+ by inhibiting Ca2+ influx in the trachealis. ..
  34. Noland T, Friday B, Maulit M, Gerton G. The sperm acrosomal matrix contains a novel member of the pentaxin family of calcium-dependent binding proteins. J Biol Chem. 1994;269:32607-14 pubmed
    ..To elucidate the structural organization of the contents within the acrosome, guinea pig sperm acrosomal apical segments were isolated and mapped by two-dimensional polyacrylamide gel electrophoresis (..
  35. Lienenklaus S, Ames R, Tornetta M, Sarau H, Foley J, Crass T, et al. Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor. J Immunol. 1998;161:2089-93 pubmed
    The interaction of human anaphylatoxin C4a with the guinea pig (gp) and human (hu) C3a receptors (C3aR) was analyzed using human rC4a, which exhibited C4a-specific activity on guinea pig platelets...
  36. Xiang A, Uchida Y, Nomura A, Iijima H, Sakamoto T, Ishii Y, et al. Involvement of thromboxane A(2) in airway mucous cells in asthma-related cough. J Appl Physiol (1985). 2002;92:763-70 pubmed
    ..These results suggest that TxA(2) derived from mucous cells potentiated cough responses to capsaicin in allergic airway inflammation...
  37. Kawaguchi M, Valencia J, Namiki T, Suzuki T, Hearing V. Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes. J Invest Dermatol. 2012;132:2791-9 pubmed publisher
    ..Diacylglycerol (DAG) increases the melanin content of human melanocytes in vitro and increases the pigmentation of guinea pig skin in vivo, but the mechanism(s) underlying those effects remain unknown...
  38. Elger W, Schneider B, Killeen Z, Jewgenow K, Dehnhard M, Friedrich M, et al. Model for Hormonal Emergency Contraception (HEC) in cycling and mated guinea pigs - Studies with the Progesterone Receptor Modulators (PRM) Ulipristal Acetate (UPA/CDB2914) and EC317. J Steroid Biochem Mol Biol. 2018;183:152-158 pubmed publisher
    A guinea pig model for new HEC methods is proposed...
  39. Tremblay Y, Fleury A, Beaudoin C, Vall e M, B langer A. Molecular cloning and expression of guinea pig cytochrome P450c17 cDNA (steroid 17 alpha-hydroxylase/17,20 lyase): tissue distribution, regulation, and substrate specificity of the expressed enzyme. DNA Cell Biol. 1994;13:1199-212 pubmed publisher
    ..A cDNA library from guinea pig adrenal was constructed, and the complete 17 alpha-hydroxylase cytochrome P450 cDNA was isolated...
  40. Hays W, Jenison S, Yamada T, Pastuszyn A, Glew R. Primary structure of the cytosolic beta-glucosidase of guinea pig liver. Biochem J. 1996;319 ( Pt 3):829-37 pubmed
    ..We purified the cytosolic beta-glucosidase from guinea pig liver and sequenced 142 amino acid residues contained within 12 trypsin digest fragments...
  41. Shanidze N, Kim A, Loewenstein S, Raphael Y, King W. Eye-head coordination in the guinea pig II. Responses to self-generated (voluntary) head movements. Exp Brain Res. 2010;205:445-54 pubmed publisher
    ..Conceptually, anticipatory responses could be produced by a feed-forward neural controller that transforms efferent motor commands for head movement into estimates of the sensory consequences of those movements. ..
  42. Mesquita C, Guimarães S, Leite Filho J, Maciel F, Rocha J, Leite J. Effect of propranolol on capsular reaction around silicone implants in guinea pigs. Acta Cir Bras. 2015;30:24-33 pubmed publisher
    ..around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model. Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used...
  43. Schultheis K, Schaefer H, Yung B, Oh J, Muthumani K, Humeau L, et al. Characterization of guinea pig T cell responses elicited after EP-assisted delivery of DNA vaccines to the skin. Vaccine. 2017;35:61-70 pubmed publisher
    ..Possessing strong similarities to human skin physiology and displaying a defined epidermis, the guinea pig is an appropriate model to study epidermal delivery of vaccine...
  44. Lin Z, Xing W, Gao C, Wang X, Qi D, Dai G, et al. Inhibitory Effect of Vascular Endothelial Growth Factor on the Slowly Activating Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes. J Am Heart Assoc. 2018;7: pubmed publisher
    ..the effects of different concentrations of VEGF on delayed rectifier potassium currents (IK) in guinea pig ventricular myocytes and their effects on action potential (AP) parameters...
  45. Doerning C, Bradley M, Lester P, Nowland M. Effects of subcutaneous alfaxalone alone and in combination with dexmedetomidine and buprenorphine in guinea pigs (Cavia porcellus). Vet Anaesth Analg. 2018;45:658-666 pubmed publisher
    ..This combination sedation protocol may be useful for nonpainful procedures requiring extended immobility. ..
  46. Pike A, Brew K, Acharya K. Crystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase. Structure. 1996;4:691-703 pubmed
    ..This general observation implies that conformational adjustments may be important for the formation and function of lactose synthase. ..
  47. Donaldson L, Haskell C, Hanley M. Functional characterization by heterologous expression of a novel cloned tachykinin peptide receptor. Biochem J. 1996;320 ( Pt 1):1-5 pubmed
    ..However, NK4 receptor activation was inhibited by nanomolar concentrations of dynorphin. The NK4 receptor is therefore a tachykinin receptor which is functionally antagonized by an endogenous opioid peptide...
  48. Pu X, Yang K. Guinea pig 11beta-hydroxysteroid dehydrogenase type 1: primary structure and catalytic properties. Steroids. 2000;65:148-56 pubmed
    ..The present study was designed to clone and characterize 11beta-HSD1 in the guinea pig, a laboratory animal known for resistance to glucocorticoids...
  49. Sato T, Takizawa T, Saito T, Kobayashi S, Hara Y, Nakaya H. Amiodarone inhibits sarcolemmal but not mitochondrial KATP channels in Guinea pig ventricular cells. J Pharmacol Exp Ther. 2003;307:955-60 pubmed
    ..Single sarcKATP channel current and flavoprotein fluorescence were measured in guinea pig ventricular myocytes to assay sarcKATP and mitoKATP channel activity, respectively...
  50. Fermini B, Ramirez D, Sun S, Bassyouni A, Hemkens M, Wisialowski T, et al. L-type calcium channel antagonism - Translation from in vitro to in vivo. J Pharmacol Toxicol Methods. 2017;84:86-92 pubmed publisher
    ..also examined in ex vivo tissue bath preparations, including relaxation of pre-constricted rat aorta and the guinea pig Langendorff isolated heart model...
  51. Uva L, Boido D, Avoli M, de Curtis M, Lévesque M. High-frequency oscillations and seizure-like discharges in the entorhinal cortex of the in vitro isolated guinea pig brain. Epilepsy Res. 2017;130:21-26 pubmed publisher
    ..or the GABAA receptor antagonist bicuculline methiodide (BMI, 50μM) in the in vitro isolated guinea pig brain preparation...
  52. Tanaka K, Yoshitomi T, Hirahara K. Elucidation of Distinct Roles of Guinea Pig CXCR1 and CXCR2 in Neutrophil Migration toward IL-8 and GROα by Specific Antibodies. Biol Pharm Bull. 2017;40:729-732 pubmed publisher
    ..In this study, we investigated the roles of guinea pig CXCR1 and CXCR2 on neutrophils in chemotactic responses to guinea pig interleukin (IL)-8 and growth-regulated ..
  53. Arts J, Kimber I. Azodicarbonamide (ADCA): A reconsideration of classification as a respiratory sensitiser. Regul Toxicol Pharmacol. 2017;89:268-278 pubmed publisher
    ..In addition, ADCA fails to elicit positive responses in mouse and guinea pig predictive tests for skin sensitisation; a lack of activity that is regarded as being inconsistent with respect ..
  54. Depreux F, Czech L, Whitlon D. Sex Genotyping of Archival Fixed and Immunolabeled Guinea Pig Cochleas. Sci Rep. 2018;8:5156 pubmed publisher
    ..We aimed to provide a protocol for sex-typing archival guinea pig tissue, whereby past experiments could be re-evaluated for sex effects...
  55. Shero N, Fiset S, Plamondon H, Thabet M, Rioux F. Increase serum cortisol in young guinea pig offspring in response to maternal iron deficiency. Nutr Res. 2018;54:69-79 pubmed publisher
    ..Previous results from our research group showed that guinea pig offspring born from ID dams were significantly more active in the Open Field Test than the controls...
  56. Hahn Y. Molecular evolution of TEPP protein genes in metazoans. Biochem Genet. 2009;47:651-64 pubmed publisher
    ..No homolog was detected in birds, insects, nematodes, and teleost fishes despite the extensive sequence data of these species, implying that the TEPP gene might be lost in these lineages. ..
  57. Tompkins J, Merriam L, Girard B, May V, Parsons R. Nickel suppresses the PACAP-induced increase in guinea pig cardiac neuron excitability. Am J Physiol Cell Physiol. 2015;308:C857-66 pubmed publisher
    ..PACAP/PAC1 receptor signaling increases excitability of neurons within the guinea pig cardiac ganglia, making them a unique system to establish mechanisms underlying PACAP modulation of neuronal ..
  58. Park C, Kalinec F. PKCα-Mediated Signals Regulate the Motile Responses of Cochlear Outer Hair Cells. Biophys J. 2015;108:2171-80 pubmed publisher
    ..Motile responses were induced in isolated guinea pig OHCs by stimulation with an 8 V/cm external alternating electrical field as 50 Hz bursts of square wave pulses (..
  59. Awasthi S, Mahairas G, Shaw C, Huang M, Koelle D, Posavad C, et al. A Dual-Modality Herpes Simplex Virus 2 Vaccine for Preventing Genital Herpes by Using Glycoprotein C and D Subunit Antigens To Induce Potent Antibody Responses and Adenovirus Vectors Containing Capsid and Tegument Proteins as T Cell Immunogens. J Virol. 2015;89:8497-509 pubmed publisher
    ..genital disease and vaginal HSV-2 DNA shedding compared with the excellent protection provided by gC2/gD2 in the guinea pig model. HSV-2 infection is a common cause of genital ulcer disease and a significant public health concern...
  60. Tabata E, Kashimura A, Kikuchi A, Masuda H, Miyahara R, Hiruma Y, et al. Chitin digestibility is dependent on feeding behaviors, which determine acidic chitinase mRNA levels in mammalian and poultry stomachs. Sci Rep. 2018;8:1461 pubmed publisher
    ..Furthermore, genomes of some herbivorous animals such as rabbit and guinea pig do not contain functional Chia genes...
  61. Torres Vargas J, Jimenez Coello M, Guzman Marin E, Acosta Viana K, Yadon Z, Gutiérrez Blanco E, et al. Quantitative and histological assessment of maternal-fetal transmission of Trypanosoma cruzi in guinea pigs: An experimental model of congenital Chagas disease. PLoS Negl Trop Dis. 2018;12:e0006222 pubmed publisher
    ..Trypanosoma cruzi infection on fertility, gestation outcome, and maternal-fetal transmission in guinea pigs (Cavia porcellus). Animals were infected with T...
  62. Veselenak R, Milligan G, Miller A, Pyles R, Bourne N. Transcriptional Analysis of the Guinea Pig Mucosal Immune Response to Intravaginal Infection with Herpes Simplex Virus Type 2. Virology. 2018;518:349-357 pubmed publisher
    ..This transcription-based array will be useful for dissection of immunity during reactivation from latency, an infection outcome that is not well recapitulated by other animal models. ..
  63. Kamei Hayashi K, Oshino R, Hara S. Amino acid sequence of glutathione S-transferase a from guinea pig liver. J Biochem. 1993;114:835-41 pubmed
    The amino acid sequence of glutathione S-transferase a from guinea pig liver was determined. Glutathione S-transferase a was composed of two identical subunits, each comprising 218 amino acid residues...
  64. Levinovitz A, Norstedt G, van den Berg S, Robinson I, Ekstrom T. Isolation of an insulin-like growth factor II cDNA from guinea pig liver: expression and developmental regulation. Mol Cell Endocrinol. 1992;89:105-10 pubmed
    Insulin-like growth factor II (IGF-II) cDNA was isolated from adult guinea pig liver by polymerase chain reaction (PCR) screening...
  65. Hu J, Bennett H, Lazure C, Solomon S. Isolation and characterization of corticostatic peptides from guinea pig bone marrow. Biochem Biophys Res Commun. 1991;180:558-65 pubmed
    Three corticostatic peptides (GP-CS1, GP-CS2 and GP-CS3) were purified from extracts of guinea pig bone marrow...
  66. Dong S, Rodger J, Mulders W, Robertson D. Tonotopic changes in GABA receptor expression in guinea pig inferior colliculus after partial unilateral hearing loss. Brain Res. 2010;1342:24-32 pubmed publisher
    ..was used to investigate the topographic distribution of the alpha1 subunit of the GABA receptor (GABRA1) in guinea pig inferior colliculus after treatments that caused a unilateral loss of peripheral neural sensitivity in the high-..
  67. Bosch M, Xue C, Rønnekleiv O. Kisspeptin expression in guinea pig hypothalamus: effects of 17?-estradiol. J Comp Neurol. 2012;520:2143-62 pubmed publisher
    Kisspeptin is essential for reproductive functions in humans. As a model for the human we have used the female guinea pig, which has a long ovulatory cycle similar to that of primates...
  68. Priyashree S, Jha S, Pattanayak S. Bronchodilatory and mast cell stabilising activity of Cressa cretica L.: evaluation through in vivo and in vitro experimental models. Asian Pac J Trop Med. 2012;5:180-6 pubmed publisher
    ..Also, the effects of these fractions were evaluated on the isolated guinea pig tracheal preparations...
  69. Hennessy M, Schiml P, Willen R, Watanasriyakul W, Johnson J, Garrett T. Selective social buffering of behavioral and endocrine responses and Fos induction in the prelimbic cortex of infants exposed to a novel environment. Dev Psychobiol. 2015;57:50-62 pubmed publisher
    ..effect of the mother, a familiar littermate, and an unfamiliar adult male on three classes of response shown by guinea pig pups in a novel environment: short latency active behaviors, particularly vocalizing; slower developing passive ..
  70. Równiak M, Bogus Nowakowska K, Robak A. The densities of calbindin and parvalbumin, but not calretinin neurons, are sexually dimorphic in the amygdala of the guinea pig. Brain Res. 2015;1604:84-97 pubmed publisher
    ..The results show that in the amygdala of the guinea pig the densities of CB and/or PV expressing neurons are sexually dimorphic with the female>male pattern of sex ..
  71. White P, Wiederhold N, Loeffler J, Najvar L, Melchers W, Herrera M, et al. Comparison of Nonculture Blood-Based Tests for Diagnosing Invasive Aspergillosis in an Animal Model. J Clin Microbiol. 2016;54:960-6 pubmed publisher
    ..Blood samples taken from a guinea pig model of IA were used for WB and serum PCR...
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    ..potential of chemicals has been traditionally assessed using regulatory accepted in vivo methods, such as guinea pig maximization test or mouse local lymph node assays (LLNAs)...
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    ..histology in combination with immunohistochemistry and in situ hybridization in a retrospective review of a guinea pig confirmation-of-virulence study, we demonstrate for the first time Ebola virus infection in hepatic oval cells, ..
  74. Tsukada S, Ichinose M, Miki K, Tatematsu M, Yonezawa S, Matsushima M, et al. Tissue- and cell-specific control of guinea pig cathepsin E gene expression. Biochem Biophys Res Commun. 1992;187:1401-8 pubmed
    Northern blotting of RNAs from normal guinea pig tissues revealed that the tissue distribution of cathepsin E mRNA was relatively limited and the highest level of the mRNA was observed in the stomach mucosa...
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    ..It had earlier been reported that guinea pig (GP) glucagon contains 40 amino acids...
  76. Kageyama T, Ichinose M, Miki K, Moriyama A, Yonezawa S, Tanji M, et al. Isolation, characterization, and structure of procathepsin E and cathepsin E from the gastric mucosa of guinea pig. Adv Exp Med Biol. 1995;362:211-21 pubmed
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    ..This in turn leads to an increase in amiloride-sensitive lung fluid clearance, which is unrelated to labour...
  79. Shi R, Asano T, Vining N, Blight A. Control of membrane sealing in injured mammalian spinal cord axons. J Neurophysiol. 2000;84:1763-9 pubmed
    The process of sealing of damaged axons was examined in isolated strips of white matter from guinea pig spinal cord by recording the "compound membrane potential," using a sucrose-gap technique, and by examining uptake of horseradish ..
  80. Alam S, Konno T, Rumi M, Dong Y, Weiner C, Soares M. Prolactin family of the guinea pig, Cavia porcellus. Endocrinology. 2010;151:3918-28 pubmed publisher
    ..The guinea pig (Cavia porcellus) has been extensively used in endocrine and reproduction research...
  81. Gao C, Fraeyman N, Eertmans F, Dhooge W, Kaufman J. Further evaluation of the biological activity of the unique gonadotropin-releasing hormone peptide in the guinea pig brain. Neurosci Lett. 2011;487:246-9 pubmed publisher
    ..compared the biological activity of a unique form of gonadotropin-releasing hormone (GnRH) in the brain of the guinea pig (gpGnRH) with mammalian GnRH (mGnRH)...
  82. Winchester W, Gore K, Glatt S, Petit W, Gardiner J, Conlon K, et al. Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther. 2014;351:259-69 pubmed publisher
    ..It demonstrated activity in vivo in the guinea pig bladder ice water and menthol challenge tests with an IC50 of 200 nM and reduced core body temperature in the ..
  83. Wenger S, Hatt J. Transurethral Cystoscopy and Endoscopic Urolith Removal in Female Guinea Pigs (Cavia porcellus). Vet Clin North Am Exot Anim Pract. 2015;18:359-67 pubmed publisher
    ..In addition, the transurethral cystoscopic removal of uroliths measuring up to 5 mm and situated within the urinary bladder is described. ..
  84. Filio Rodríguez G, Estrada Garcia I, Arce Paredes P, Moreno Altamirano M, Islas Trujillo S, Ponce Regalado M, et al. In vivo induction of neutrophil extracellular traps by Mycobacterium tuberculosis in a guinea pig model. Innate Immun. 2017;23:625-637 pubmed publisher
    ..tuberculosis. In vitro, guinea pig neutrophils also produced NETs in response to M. tuberculosis...
  85. Hong L, Xu X, Chen L, Li B, Wu D, Hu M, et al. The anti-HSV-2 effect of alumen: In vitro and in vivo experimental studies. J Huazhong Univ Sci Technolog Med Sci. 2011;31:828-833 pubmed publisher
    ..It was concluded that alumen had an in vitro anti-HSV-2 effect through multiple approaches and it could suppress in vivo vaginal HSV-2 infection of guinea pig to some extent.
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    ..2-AR tachyphylaxis was induced with salbutamol, salmeterol and formoterol on guinea pig tracheas...
  87. Han B, Poppinga W, Zuo H, Zuidhof A, Bos I, Smit M, et al. The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease. Sci Rep. 2016;6:26928 pubmed publisher
    ..Using a guinea pig model of lipopolysaccharide (LPS)-induced neutrophilia, we demonstrated that Sul-121 inhalation dose-dependently ..
  88. Obara K, Kobayashi Y, Chino D, Tanaka Y. Effect of distigmine on the contractile response of guinea pig urinary bladder to electrical field stimulation. Eur J Pharmacol. 2017;809:209-214 pubmed publisher
    ..In isolated guinea pig UBSM tissues, EFS (1-16Hz) produced tetrodotoxin-sensitive, frequency-dependent contractions...
  89. Gou X, Wang W, Zou S, Qi Y, Xu Y. Protein kinase C epsilon mediates the inhibition of angiotensin II on the slowly activating delayed-rectifier potassium current through channel phosphorylation. J Mol Cell Cardiol. 2018;116:165-174 pubmed publisher
    ..The whole-cell patch-clamp technique was used to record IKs in isolated guinea pig ventricular cardiomyocytes and in human embryonic kidney (HEK) 293 cells co-transfected with human KCNQ1/KCNE1 ..
  90. Provost P, Tremblay Y, El Amine M, B langer A. Guinea pig apolipoprotein D RNA diversity, and developmental and gestational modulation of mRNA levels. Mol Cell Endocrinol. 1995;109:225-36 pubmed
    We have isolated and characterized two molecular types of guinea pig (GP) apolipoprotein D (apoD) cDNA...
  91. Brandts B, Bender K, Weismuller P, Pott L, Trappe H. Uncoupling of ATP-sensitive potassium current from cell metabolism due to antisense oligonucleotides against sulfonylurea receptor in guinea-pig atrial myocytes. Pacing Clin Electrophysiol. 2000;23:1816-9 pubmed
    ..ODN-induced metabolic uncoupling of IK(ATP) may be a useful experimental tool. A reduced sensitivity of IK(ATP) to intracellular ATP concentrations may be of clinical interest...
  92. Kimitsuki T. Nitric oxide influences potassium currents in inner hair cells isolated from guinea-pig cochlea. Auris Nasus Larynx. 2015;42:360-4 pubmed publisher
    ..3±2.7nA in 1mM SNP solutions, showing a significant difference. NO acts as a K channel modulator in IHCs. A fast K current suppression may account for the high-frequency hearing impairment by the prevention of fast repolarization. ..