Alias: Orangutan, orang utan, Sumatran orangutan, Pongo abelii, Pongo pygmaeus abelii, Pongo pygmaeus abeli

Top Publications

  1. Blaise S, Ruggieri A, Dewannieux M, Cosset F, Heidmann T. Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians. J Virol. 2004;78:1050-4 pubmed
    ..The functional characterization of the identified envelopes is strongly indicative of an ancestral retrovirus infection and endogenization, with some of the envelope functions subsequently retained in evolution...
  2. Herv C, Forrest G, L wer R, Griffiths D, Venables P. Conservation and loss of the ERV3 open reading frame in primates. Genomics. 2004;83:940-3 pubmed publisher
    ..The evolutionary conservation of the ERV3 envelope suggests a beneficial function, though the loss from gorilla shows that it is not essential for survival or reproduction...
  3. Cáceres M, Thomas J. The gene of retroviral origin Syncytin 1 is specific to hominoids and is inactive in Old World monkeys. J Hered. 2006;97:100-6 pubmed
    ..Our results indicate that Syncytin 1 is indeed a hominoid-specific gene and illustrate the complex and dynamic process associated with the origin of new genes...
  4. Kjeldbjerg A, Villesen P, Aagaard L, Pedersen F. Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution. BMC Evol Biol. 2008;8:266 pubmed publisher
    ..Together with the placenta-specific expression of the human and baboon ENVV1 and ENVV2 envelope genes, these data provide strong evidence of a beneficial role for the host. ..
  5. Huang Q, Wu Y, Qin C, He W, Wei X. Phylogenetic and structural analysis of the phospholipase A2 gene family in vertebrates. Int J Mol Med. 2015;35:587-96 pubmed publisher
    ..species, including the human, house mouse, Norway rat, pig, dog, chicken, cattle, African clawed frog, Sumatran orangutan and the zebrafish species...
  6. Wich S, Singleton I, Nowak M, Utami Atmoko S, Nisam G, Arif S, et al. Land-cover changes predict steep declines for the Sumatran orangutan (Pongo abelii). Sci Adv. 2016;2:e1500789 pubmed publisher
    ..To date, the total Sumatran orangutan population has been estimated at 6600 individuals...
  7. Liu C, Zhang W, Yang D, Liu Y. Molecular Characterization, Polymorphism, and Association of Porcine GADD45G Gene. Anim Biotechnol. 2015;26:230-6 pubmed publisher
    ..protein of 159 amino acids that shares high homology with the GADD45G of nine species: chimpanzee (97%), sumatran orangutan (97%), white-tufted-ear marmoset (97%), northern white-cheeked gibbon (97%), cattle (97%), human (97%), ..
  8. Puppione D, Ryan C, Bassilian S, Souda P, Xiao X, Ryder O, et al. Detection of two distinct forms of apoC-I in great apes. Comp Biochem Physiol Part D Genomics Proteomics. 2010;5:73-9 pubmed publisher
    ..with the HDL of the following great apes: bonobo (Pan paniscus), chimpanzee (Pan troglodytes), and the Sumatran orangutan (Pongo abelii)...
  9. Stringer E, Cossaboon C, Han S, Taylor Cousar J. SINUSITIS, BRONCHIECTASIS, AND FLATUS IN A SUMATRAN ORANGUTAN (PONGO ABELII): COULD THIS BE CYSTIC FIBROSIS?. J Zoo Wildl Med. 2016;47:347-50 pubmed publisher
    A 31-yr-old male Sumatran orangutan (Pongo abelii) presented with 14 yr of chronic purulent nasal drainage and cough with intermittent exacerbation of symptoms requiring systemic antibiotic treatment...

More Information


  1. Power M, Schulkin J, Drought H, Milligan L, Murtough K, Bernstein R. Patterns of milk macronutrients and bioactive molecules across lactation in a western lowland gorilla (Gorilla gorilla) and a Sumatran orangutan (Pongo abelii). Am J Primatol. 2017;79:1-11 pubmed publisher
    ..growth factors (EGF-R and TGF-β2-RIII) in milk samples collected between days 175 and 313 postpartum from a Sumatran orangutan (Pongo abelii) and between days 3 and 1,276 from a western lowland gorilla (Gorilla gorilla), and compare ..
  2. Sauciuc G, Persson T, Bååth R, Bobrowicz K, Osvath M. Affective forecasting in an orangutan: predicting the hedonic outcome of novel juice mixes. Anim Cogn. 2016;19:1081-1092 pubmed
    ..stimuli, we devised a non-verbal method for assessing affective forecasting and tested comparatively one Sumatran orangutan and ten human participants...
  3. Maclachlan N, Hunt G, Fowkes S, Frost M, Miller J, Purcell Jones G, et al. Successful treatment of infertility in a female Sumatran orangutan Pongo abelii. Zoo Biol. 2017;36:132-135 pubmed publisher
    In 2011, a female Sumatran orangutan housed at Durrell Wildlife Conservation Trust became infertile following a massive antepartum hemorrhage in labor and the delivery of a stillborn infant. The placenta was infected with Pantoea sp...
  4. Nilsson D, Gramotnev G, Baxter G, Butler J, Wich S, McAlpine C. Community motivations to engage in conservation behavior to conserve the Sumatran orangutan. Conserv Biol. 2016;30:816-26 pubmed publisher
    ..heteronomous versus autonomous approaches to community-based conservation programs through a case study of Sumatran orangutan (Pongo abelii) conservation in 3 villages in Indonesia...
  5. Staes N, Sherwood C, Wright K, de Manuel M, Guevara E, Marques Bonet T, et al. FOXP2 variation in great ape populations offers insight into the evolution of communication skills. Sci Rep. 2017;7:16866 pubmed publisher
    ..protein modeling indicate a biochemical effect of the substitution in orangutans, and because of its presence solely in the Sumatran orangutan species, the mutation may be associated with reported population differences in vocalizations.
  6. Trivedi N, Tong Q, Raman K, Bhagwandin V, Caughey G. Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates. J Immunol. 2007;179:6072-9 pubmed
    ..of variation, we compared genes from a range of primates, including humans, great apes (chimpanzee, gorilla, orangutan), Old- and New-World monkeys (macaque and marmoset), and a prosimian (galago), tracking key changes...
  7. de Groot N, Heijmans C, van der Wiel M, Blokhuis J, Mulder A, Guethlein L, et al. Complex MHC Class I Gene Transcription Profiles and Their Functional Impact in Orangutans. J Immunol. 2016;196:750-8 pubmed publisher
    ..An in-depth analysis of the MHC class I gene repertoire in the two orangutan species, Pongo abelii and Pongo pygmaeus, is presented in this article...
  8. Zhang Z, Liu J, Li M, Yang H, Zhang C. Evolutionary dynamics of the interferon-induced transmembrane gene family in vertebrates. PLoS ONE. 2012;7:e49265 pubmed publisher
    ..Because primates have experienced a long history of viral infection, such rapid expansion and positive selection suggests that the evolution of primate IR-IFITM genes is associated with broad-spectrum antiviral activity...
  9. Premzl M, Gamulin V. Comparative genomic analysis of prion genes. BMC Genomics. 2007;8:1 pubmed publisher
    ..It is likely that the conserved genomic elements identified in this analysis represent bona fide cis-elements. However, this idea needs to be confirmed by functional assays in transgenic systems...
  10. Agarwal S, Harada J, Schreifels J, Lech P, Nikolai B, Yamaguchi T, et al. Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection. Proc Natl Acad Sci U S A. 2006;103:15933-8 pubmed publisher
    ..Finally, we reconcile our findings and other published data to suggest a model for the involvement of the proteasome in the early phase of the retroviral life cycle...
  11. Wieles B, Pool J, Wilke M, Weber M, Kolb H, Bontrop R, et al. The diallelic locus encoding the minor histocompatibility antigen HA-1 is evolutionarily conserved. Tissue Antigens. 2006;68:62-5 pubmed
    ..Interestingly, both the HA-1(H) T-cell epitope and its non-immunogenic counterpart HA-1(R) are present in the latter species. Thus, the HA-1 allelic polymorphism is conserved in evolution in primates and dogs. ..
  12. Sugiura K, Naito K, Endo T, Tojo H. Study of germinal vesicle requirement for the normal kinetics of maturation/M-phase-promoting factor activity during porcine oocyte maturation. Biol Reprod. 2006;74:593-600 pubmed publisher
    ..These results indicate that GV is not required for the activation of MPF during the first meiosis, but that it is required for the second meiosis because of its promotion of CCNB1 accumulation...
  13. Lanteri M, Giordanengo V, Vidal F, Gaudray P, Lefebvre J. A complete alpha1,3-galactosyltransferase gene is present in the human genome and partially transcribed. Glycobiology. 2002;12:785-92 pubmed
    ..Finally, we show that these truncated transcripts are overexpressed in cell lines with modifications of O-glycans. ..
  14. Whanger P. Selenoprotein W: a review. Cell Mol Life Sci. 2000;57:1846-52 pubmed
    ..Studies with tissue cultures of muscle and brain cells indicated that selenium influenced Se-W levels. Although the metabolic function of Se-W is unknown, preliminary data suggest that it has an antioxidant function. ..
  15. Harrison P, Khachane A, Kumar M. Genomic assessment of the evolution of the prion protein gene family in vertebrates. Genomics. 2010;95:268-77 pubmed publisher
    ..even-toed ungulates and rodents, is conserved in all high-coverage genome assemblies of primates (human, chimp, orang utan and macaque), and is, at least, likely to have fallen out of use during primate speciation...
  16. Malfavon Borja R, Feschotte C. Fighting fire with fire: endogenous retrovirus envelopes as restriction factors. J Virol. 2015;89:4047-50 pubmed publisher
    ..Based on the proposed mode of restriction and the domain architecture of known antiretroviral env, we argue that many more env gene-derived restriction factors await discovery in vertebrate genomes, including the human genome. ..
  17. Gkika D, Lemonnier L, Shapovalov G, Gordienko D, Poux C, Bernardini M, et al. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. J Cell Biol. 2015;208:89-107 pubmed publisher
    ..The identification of TCAFs introduces a novel mechanism for modulation of TRPM8 channel activity. ..
  18. Coffey R, Knutson M. The plasma membrane metal-ion transporter ZIP14 contributes to nontransferrin-bound iron uptake by human ?-cells. Am J Physiol Cell Physiol. 2017;312:C169-C175 pubmed publisher
    ..Collectively, these observations identify ZIP14 as a major contributor to NTBI uptake by ?-cells and suggest differential regulation of ZIP14 in primary human islets compared with other cell types such as hepatocytes. ..
  19. Galili U. Significance of the evolutionary α1,3-galactosyltransferase (GGTA1) gene inactivation in preventing extinction of apes and old world monkeys. J Mol Evol. 2015;80:1-9 pubmed publisher
    ..A present outcome of this evolutionary event is the anti-Gal-mediated rejection of mammalian xenografts expressing α-gal epitopes in humans, apes, and Old World monkeys. ..
  20. Pausch H, Kölle S, Wurmser C, Schwarzenbacher H, Emmerling R, Jansen S, et al. A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle. PLoS Genet. 2014;10:e1004044 pubmed publisher
    ..Our results demonstrate that deficiency of TMEM95 severely compromises male reproductive performance in cattle and reveal for the first time a phenotypic effect associated with genomic variation in TMEM95. ..
  21. Ballew B, Joseph V, De S, Sarek G, Vannier J, Stracker T, et al. A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet. 2013;9:e1003695 pubmed publisher
    ..This study further implicates RTEL1 in the etiology of DC/HH and immunodeficiency, and identifies the first known homozygous autosomal recessive disease-associated mutation in RTEL1...
  22. Vuch J, Siori M, Bigatti M, Segat L, De Fabrizio G, Crovella S. Analysis of the beta-globin gene in DNA of suspected thalassemic great apes. Genet Mol Res. 2013;12:1731-9 pubmed publisher
    ..We did not find any mutation in the ?-globin gene of Ptr and Ppy; therefore, we conclude that, in spite of skeletal alterations, the 2 subjects analyzed were not affected by ?-thalassemia. ..
  23. Esnault C, Cornelis G, Heidmann O, Heidmann T. Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation. PLoS Genet. 2013;9:e1003400 pubmed publisher
  24. Carnahan S, Jensen Seaman M. Hominoid seminal protein evolution and ancestral mating behavior. Am J Primatol. 2008;70:939-48 pubmed publisher
    ..transglutaminase (TGM4) gene in human, chimpanzee, bonobo, western lowland gorilla, eastern lowland gorilla, orangutan, and siamang, including multiple humans, chimps, and gorillas...
  25. Zhang Y, Ryder O, Zhang Y. Sequence evolution of the CCR5 chemokine receptor gene in primates. Mol Biol Evol. 1999;16:1145-54 pubmed
    ..Ka/Ks ratios from cercopithecines and colobines are significantly different, implying that selective pressures have played different roles in the two lineages. ..
  26. Bera T, Hahn Y, Lee B, Pastan I. TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. Biochem Biophys Res Commun. 2003;312:1209-15 pubmed
    ..Selective expression of TEPP in testis, prostate, and in placenta and its high conservation among different species indicate that TEPP might have a role in reproductive biology. ..
  27. Hamilton B. alpha-Synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates. Genomics. 2004;83:739-42 pubmed publisher
    ..These results have implications for interpreting Parkinson disease models and suggest that other long-lived mammals have different mechanisms to forestall alpha-synucleinopathy...
  28. Yisraeli J. VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins. Biol Cell. 2005;97:87-96 pubmed publisher
    ..Such a 'post-transcriptional operon' model, as proposed by Keene and Tenenbaum [(2002) Mol. Cell 9, 1161-1167], can explain the differential, integrated action of multiple RNA-binding proteins on mRNA targets...
  29. Song B, Gold B, O hUigin C, Javanbakht H, Li X, Stremlau M, et al. The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates. J Virol. 2005;79:6111-21 pubmed publisher
    ..The results are consistent with a role for TRIM5alpha in innate immunity against retroviruses...
  30. Hahn Y, Jeong S, Lee B. Inactivation of MOXD2 and S100A15A by exon deletion during human evolution. Mol Biol Evol. 2007;24:2203-12 pubmed publisher
    ..We propose that modification or inactivation of MOXD2 and S100A15A genes have contributed to the loss of certain smell sense in humans and to the development of human skin...
  31. Bechtel S, Rosenfelder H, Duda A, Schmidt C, Ernst U, Wellenreuther R, et al. The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007;8:399 pubmed publisher
  32. Sawyer S, Emerman M, Malik H. Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals. PLoS Pathog. 2007;3:e197 pubmed publisher
    ..Astonishingly, this same loop is under positive selection in the multiple cow TRIM5 genes as well, indicating that this small structural loop may be a viral recognition motif spanning a hundred million years of mammalian evolution...
  33. Trivedi N, Raymond W, Caughey G. Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution. J Allergy Clin Immunol. 2008;121:1262-8 pubmed publisher
    ..Prosimian (lemur), monkey (macaque), great ape (orangutan, gorilla, and chimpanzee), and human delta-tryptase genes were identified by means of data mining and genomic ..
  34. Sugimoto J, Sugimoto M, BERNSTEIN H, Jinno Y, Schust D. A novel human endogenous retroviral protein inhibits cell-cell fusion. Sci Rep. 2013;3:1462 pubmed publisher
    ..Identification of the first host cell-encoded inhibitor of mammalian cell fusion may encourage improved understanding of cell fusion mechanisms, of placental morphogenesis and of diseases resulting from abnormal cell fusion. ..
  35. Than N, Romero R, Goodman M, Weckle A, Xing J, Dong Z, et al. A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. Proc Natl Acad Sci U S A. 2009;106:9731-6 pubmed publisher
  36. Hahn Y. Molecular evolution of TEPP protein genes in metazoans. Biochem Genet. 2009;47:651-64 pubmed publisher
    ..No homolog was detected in birds, insects, nematodes, and teleost fishes despite the extensive sequence data of these species, implying that the TEPP gene might be lost in these lineages. ..
  37. Vallender E, Xie Z, Westmoreland S, Miller G. Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs. BMC Evol Biol. 2010;10:51 pubmed publisher
    ..By placing the trace amine associated receptors in an evolutionary context we can better understand their function and their potential associations with behavior and neurological disease. ..
  38. Xu X, Arnason U. The mitochondrial DNA molecule of Sumatran orangutan and a molecular proposal for two (Bornean and Sumatran) species of orangutan. J Mol Evol. 1996;43:431-7 pubmed
    The complete mitochondrial DNA (mtDNA) molecule of Sumatran orangutan, plus the complete mitochondrial control region of another Sumatran specimen and the control regions and five protein-coding genes of two specimens of Bornean orangutan ..
  39. Narita Y, Oda S, Takenaka O, Kageyama T. Lineage-specific duplication and loss of pepsinogen genes in hominoid evolution. J Mol Evol. 2010;70:313-24 pubmed publisher
    Fourteen different pepsinogen-A cDNAs and one pepsinogen-C cDNA have been cloned from gastric mucosa of the orangutan, Pongo pygmaeus. Encoded pepsinogens A were classified into two groups, i.e...
  40. Dang L, Purvis A, Huang R, Westfield L, Sadler J. Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor. J Biol Chem. 2011;286:25763-9 pubmed publisher
    ..These results suggest that pH sensing by evolutionarily conserved His residues facilitates the assembly and packaging of VWF multimers upon arrival in the trans-Golgi...
  41. Cheng D, Li Y, Huang J. Molecular evolution of the primate ?-/?-defensin multigene family. PLoS ONE. 2014;9:e97425 pubmed publisher
  42. Demogines A, East A, Lee J, Grossman S, Sabeti P, Paull T, et al. Ancient and recent adaptive evolution of primate non-homologous end joining genes. PLoS Genet. 2010;6:e1001169 pubmed publisher
    ..We propose that an ongoing evolutionary arms race between viruses and NHEJ genes may be driving the surprisingly rapid evolution of these critical genes...