Northern white-cheeked gibbon


Alias: White-cheeked Gibbon, Hylobates leucogenys, Nomascus leucogenys, Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys Ogilby, 1840, Hylobates leucogenys leucogenys, Nomascus leucogenys leucogenys

Top Publications

  1. Kaiser S, Malik H, Emerman M. Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein. Science. 2007;316:1756-8 pubmed
  2. Elde N, Child S, Geballe A, Malik H. Protein kinase R reveals an evolutionary model for defeating viral mimicry. Nature. 2009;457:485-9 pubmed publisher
  3. Lim E, Malik H, Emerman M. Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses. J Virol. 2010;84:7124-34 pubmed publisher
    ..Our combined evolutionary and functional studies have allowed us to reconstruct the host-pathogen interactions that have shaped Tetherin and its lentivirus-encoded antagonists...
  4. Lim E, Fregoso O, McCoy C, Matsen F, Malik H, Emerman M. The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe. 2012;11:194-204 pubmed publisher
    ..We conclude that vpr neofunctionalized to degrade SAMHD1 even prior to the birth of a separate vpx gene, thereby initiating an evolutionary arms race with SAMHD1...
  5. Blaise S, de Parseval N, B nit L, Heidmann T. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Proc Natl Acad Sci U S A. 2003;100:13013-8 pubmed publisher
  6. Demogines A, East A, Lee J, Grossman S, Sabeti P, Paull T, et al. Ancient and recent adaptive evolution of primate non-homologous end joining genes. PLoS Genet. 2010;6:e1001169 pubmed publisher
    ..We propose that an ongoing evolutionary arms race between viruses and NHEJ genes may be driving the surprisingly rapid evolution of these critical genes...
  7. Liu C, Zhang W, Yang D, Liu Y. Molecular Characterization, Polymorphism, and Association of Porcine GADD45G Gene. Anim Biotechnol. 2015;26:230-6 pubmed publisher
    ..01). Therefore, porcine GADD45G gene could be a useful candidate gene in selection for increasing the litter size. These data serve as a foundation for further insight into this novel porcine gene. ..
  8. Hradec M, Bolechová P, Svobodová I. Production of a female-specific great call in an immature male gibbon, the Nomascus genus. Primates. 2016;57:445-8 pubmed publisher
    ..We recorded vocal behaviour of a juvenile male northern white-cheeked gibbon (Nomascus leucogenys). The male produced female-specific great calls...
  9. Roncaglioni M, Falanga A, D Alessandro A, Alessio M, Casali B, Donati M. Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma. Haematologica. 1989;74:143-7 pubmed
    ..The accumulation of endogenous substrate(s) and the depression of the CP activity by warfarin raises the possibility that CP represents at least one of the substrates for gamma-glutamyl carboxylase in this experimental tumor tissue. ..

More Information


  1. Sawyer S, Emerman M, Malik H. Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals. PLoS Pathog. 2007;3:e197 pubmed publisher
    ..Astonishingly, this same loop is under positive selection in the multiple cow TRIM5 genes as well, indicating that this small structural loop may be a viral recognition motif spanning a hundred million years of mammalian evolution...
  2. Bardet C, Delgado S, Sire J. MEPE evolution in mammals reveals regions and residues of prime functional importance. Cell Mol Life Sci. 2010;67:305-20 pubmed publisher
    ..Our data indicate that MEPE was involved in various functions (bone and eggshell mineralization) prior to acquiring those currently known in placental mammals...
  3. Ortiz M, Bleiber G, Martinez R, Kaessmann H, Telenti A. Patterns of evolution of host proteins involved in retroviral pathogenesis. Retrovirology. 2006;3:11 pubmed publisher
    ..The strong sequence conservation of the TRIM19/PML sequences among primates suggests that this gene does not play a role in antiretroviral defense...
  4. Herv C, Forrest G, L wer R, Griffiths D, Venables P. Conservation and loss of the ERV3 open reading frame in primates. Genomics. 2004;83:940-3 pubmed publisher
    ..The evolutionary conservation of the ERV3 envelope suggests a beneficial function, though the loss from gorilla shows that it is not essential for survival or reproduction...
  5. Mallet F, Bouton O, Prudhomme S, Cheynet V, Oriol G, Bonnaud B, et al. The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology. Proc Natl Acad Sci U S A. 2004;101:1731-6 pubmed publisher
    ..This functional preservation among humans and during evolution strongly argued for the involvement of this recently acquired retroviral envelope glycoprotein in hominoid placental physiology...
  6. Malfavon Borja R, Feschotte C. Fighting fire with fire: endogenous retrovirus envelopes as restriction factors. J Virol. 2015;89:4047-50 pubmed publisher
    ..Based on the proposed mode of restriction and the domain architecture of known antiretroviral env, we argue that many more env gene-derived restriction factors await discovery in vertebrate genomes, including the human genome. ..
  7. Mitchell P, Patzina C, Emerman M, Haller O, Malik H, Kochs G. Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA. Cell Host Microbe. 2012;12:598-604 pubmed publisher
    ..Taken together, our findings identify a genetic determinant of MxA target recognition and suggest a model by which MxA achieves antiviral breadth without compromising viral specificity...
  8. Kurosaki M, Bolis M, Fratelli M, Barzago M, Pattini L, Perretta G, et al. Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression. Cell Mol Life Sci. 2013;70:1807-30 pubmed publisher
    ..We identify chimeric RNAs from the human AOX3 and AOX3L1 pseudogenes with potential to encode a novel microRNA. ..
  9. Sugimoto J, Sugimoto M, BERNSTEIN H, Jinno Y, Schust D. A novel human endogenous retroviral protein inhibits cell-cell fusion. Sci Rep. 2013;3:1462 pubmed publisher
    ..Identification of the first host cell-encoded inhibitor of mammalian cell fusion may encourage improved understanding of cell fusion mechanisms, of placental morphogenesis and of diseases resulting from abnormal cell fusion. ..
  10. Meyerson N, Rowley P, Swan C, Le D, Wilkerson G, Sawyer S. Positive selection of primate genes that promote HIV-1 replication. Virology. 2014;454-455:291-8 pubmed publisher
    ..We discuss how evolutionary analysis can aid the study of host factors for viral replication, just as it has the study of host immunity systems. ..
  11. Lou D, McBee R, Le U, Stone A, Wilkerson G, Demogines A, et al. Rapid evolution of BRCA1 and BRCA2 in humans and other primates. BMC Evol Biol. 2014;14:155 pubmed publisher
    ..A hypothesis where viruses are the drivers of this natural selection is discussed. ..
  12. Duggal N, Malik H, Emerman M. The breadth of antiviral activity of Apobec3DE in chimpanzees has been driven by positive selection. J Virol. 2011;85:11361-71 pubmed publisher
    ..Despite a difference in target specificities between human and chimpanzee Apobec3DE, Apobec3DE is likely to currently play a role in host defense against retroelements in both species...
  13. Barber M, Elde N. Nutritional immunity. Escape from bacterial iron piracy through rapid evolution of transferrin. Science. 2014;346:1362-6 pubmed publisher
    ..These findings identify a central role for nutritional immunity in the persistent evolutionary conflicts between primates and bacterial pathogens. ..
  14. Patel M, Loo Y, Horner S, Gale M, Malik H. Convergent evolution of escape from hepaciviral antagonism in primates. PLoS Biol. 2012;10:e1001282 pubmed publisher
    ..Our analyses also provide a means by which primates might clear infections by extant hepaciviruses like HCV...
  15. Niu A, Wang Y, Zhang H, Liao C, Wang J, Zhang R, et al. Rapid evolution and copy number variation of primate RHOXF2, an X-linked homeobox gene involved in male reproduction and possibly brain function. BMC Evol Biol. 2011;11:298 pubmed publisher
  16. Bekpen C, Marques Bonet T, Alkan C, Antonacci F, Leogrande M, Ventura M, et al. Death and resurrection of the human IRGM gene. PLoS Genet. 2009;5:e1000403 pubmed publisher
    ..Such dynamism in structure and evolution may be critical for a gene family locked in an arms race with an ever-changing repertoire of intracellular parasites...
  17. Zhang J, Zhang Y, Rosenberg H. Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkey. Nat Genet. 2002;30:411-5 pubmed publisher
    ..Our findings demonstrate the contribution of gene duplication to organismal adaptation and show the power of combining sequence analysis and functional assays in delineating the molecular basis of adaptive evolution...