Rhesus monkey


Alias: rhesus macaque, rhesus macaques, rhesus monkeys, Macaca mulatta

Top Publications

  1. Ortmeyer H, Sajan M, Miura A, Kanoh Y, Rivas J, Li Y, et al. Insulin signaling and insulin sensitizing in muscle and liver of obese monkeys: peroxisome proliferator-activated receptor gamma agonist improves defective activation of atypical protein kinase C. Antioxid Redox Signal. 2011;14:207-19 pubmed publisher
    ..are considered key integrators of metabolism, we sought to determine in biopsies from lean and obese aging rhesus monkeys the nature of defects in insulin activation and, further, the potential for mitigation of such defects by an ..
  2. Watson K, Ghodasra J, Platt M. Serotonin transporter genotype modulates social reward and punishment in rhesus macaques. PLoS ONE. 2009;4:e4156 pubmed publisher
    ..Here we show that length polymorphisms in 5-HTTLPR predict social reward and punishment in rhesus macaques, a species in which 5-HTTLPR variation is analogous to that of humans...
  3. Loffredo J, Sidney J, Bean A, Beal D, Bardet W, Wahl A, et al. Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity. J Immunol. 2009;182:7763-75 pubmed publisher
    ..In a similar fashion, 50% of Mamu-B*08-positive Indian rhesus macaques control SIVmac239 replication and become elite controllers with chronic-phase viremia <1000 viral RNA ..
  4. Wang Y, Bergmeier L, Stebbings R, Seidl T, Whittall T, Singh M, et al. Mucosal immunization in macaques upregulates the innate APOBEC 3G anti-viral factor in CD4(+) memory T cells. Vaccine. 2009;27:870-81 pubmed publisher
    ..In vivo studies of APOBEC3G (A3G) were carried out in rhesus macaques, following mucosal immunization with SIV antigens and CCR5 peptides, linked to the 70kDa heat shock protein...
  5. Gupta R, Mlcochova P, Pelchen Matthews A, Petit S, Mattiuzzo G, Pillay D, et al. Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration. Proc Natl Acad Sci U S A. 2009;106:20889-94 pubmed publisher
    ..SIVtan) encodes an envelope glycoprotein (SIVtan Env) able to counteract tetherin from Tantalus monkeys, rhesus monkeys, sooty mangabeys, and humans, but not from pigs...
  6. Reynolds M, Sacha J, Weiler A, Borchardt G, Glidden C, Sheppard N, et al. The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge. J Virol. 2011;85:9637-40 pubmed publisher
    It has recently been shown that polymorphism at the rhesus macaque TRIM5 locus can affect simian immunodeficiency virus (SIV) replication. Here we show that TRIM5 alleles can also affect acquisition of SIVsmE660...
  7. Higham J, Barr C, Hoffman C, Mandalaywala T, Parker K, Maestripieri D. Mu-opioid receptor (OPRM1) variation, oxytocin levels and maternal attachment in free-ranging rhesus macaques Macaca mulatta. Behav Neurosci. 2011;125:131-6 pubmed publisher
    ..similar nonsynonymous mu-opioid receptor (OPRM1) SNPs have arisen and been maintained in humans (A118G) and rhesus macaques Macaca mulatta (C77G)...
  8. Blokhuis J, Doxiadis G, Bontrop R. A splice site mutation converts an inhibitory killer cell Ig-like receptor into an activating one. Mol Immunol. 2009;46:640-8 pubmed publisher
    The killer cell Ig-like receptor (KIR) 3DH protein in rhesus macaques (Macaca mulatta) is thought to be an activating one because it contains a charged arginine in its transmembrane domain and has a truncated cytoplasmic domain...
  9. Lim E, Malik H, Emerman M. Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses. J Virol. 2010;84:7124-34 pubmed publisher
    ..Our combined evolutionary and functional studies have allowed us to reconstruct the host-pathogen interactions that have shaped Tetherin and its lentivirus-encoded antagonists...

More Information

Publications124 found, 100 shown here

  1. Yang H, Ji X, Zhao G, Ning J, Zhao Q, Aiken C, et al. Structural insight into HIV-1 capsid recognition by rhesus TRIM5?. Proc Natl Acad Sci U S A. 2012;109:18372-7 pubmed publisher
    ..Our results provide molecular insights into the mechanisms of TRIM5?-mediated retroviral restriction...
  2. Hofmann Lehmann R, Williams A, Swenerton R, Li P, Rasmussen R, Chenine A, et al. Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection. AIDS Res Hum Retroviruses. 2002;18:627-39 pubmed
    ..cytokine and beta-chemokine profiles during pathogenesis of lentiviral infection and progression to AIDS in rhesus macaques, we established new quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assays ..
  3. Ramaswamy S, Gibbs R, Plant T. Studies of the localisation of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta) and the effect of kisspeptin on the release of non-gonadotropic pituitary hormones. J Neuroendocrinol. 2009;21:795-804 pubmed publisher
    ..also influences the function of the primate pituitary directly, two experiments were performed in adult male rhesus monkeys. First, the distribution of kisspeptin-containing cells in the pituitary was described using fluorescence ..
  4. Sakuma R, Ohmine S, Ikeda Y. Determinants for the rhesus monkey TRIM5alpha-mediated block of the late phase of HIV-1 replication. J Biol Chem. 2010;285:3784-93 pubmed publisher
    b>Rhesus monkey TRIM5alpha (TRIM5alpharh) includes RING, B-box, coiled-coil, and B30.2(PRYSPRY) domains and blocks HIV-1 infection by targeting HIV-1 core through a B30.2(PRYSPRY) domain...
  5. Liu H, Wang Y, Liao C, Kuang Y, Zheng Y, Su B. Adaptive evolution of primate TRIM5alpha, a gene restricting HIV-1 infection. Gene. 2005;362:109-16 pubmed publisher
  6. Coon S, Del Olmo E, Young W, Klein D. Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC J Clin Endocrinol Metab. 2002;87:4699-706 pubmed publisher
    ..In this report AANAT was studied in the rhesus macaque to better understand human melatonin regulation...
  7. McNatt M, Zang T, Hatziioannou T, Bartlett M, Fofana I, Johnson W, et al. Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants. PLoS Pathog. 2009;5:e1000300 pubmed publisher
    ..Tetherin variants found in rhesus macaques (rh), African green monkeys (agm) and mice were able to inhibit HIV-1 particle release, but were resistant to ..
  8. Yu K, Qiu C, Yang G, Zong C, Xing H, Shao Y, et al. Alteration of serotonin transporter messenger RNA level in the peripheral blood mononuclear cells from simian/human immunodeficiency virus infected Chinese rhesus macaques (Macaca mulatta). Brain Behav Immun. 2010;24:298-305 pubmed publisher
    ..levels of SERT mRNA in the peripheral blood mononuclear cells (PBMCs) and various tissues from normal Chinese rhesus macaques, in PBMCs from 32 SHIV-sf162p4 infected rhesus macaques and from 8 rhesus macaques before and 7, 14, 21, 28 ..
  9. Serra Moreno R, Jia B, Breed M, Alvarez X, Evans D. Compensatory changes in the cytoplasmic tail of gp41 confer resistance to tetherin/BST-2 in a pathogenic nef-deleted SIV. Cell Host Microbe. 2011;9:46-57 pubmed publisher
    ..domain of SIV gp41, acquired by a nef-deleted virus that regained a pathogenic phenotype in infected rhesus macaques, restore resistance to tetherin...
  10. Newman R, Hall L, Connole M, Chen G, Sato S, Yuste E, et al. Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha. Proc Natl Acad Sci U S A. 2006;103:19134-9 pubmed
  11. Nakajima T, Walkup R, Tochigi A, Shearer T, Azuma M. Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes. Exp Eye Res. 2007;85:651-8 pubmed publisher
    ..cDNA for lacritin from rhesus macaque contained 547 bp, with 411 bp in an open reading frame (ORF) encoding a protein of 137 amino acids...
  12. Otting N, Heijmans C, van der Wiel M, de Groot N, Doxiadis G, Bontrop R. A snapshot of the Mamu-B genes and their allelic repertoire in rhesus macaques of Chinese origin. Immunogenetics. 2008;60:507-14 pubmed publisher
    The major histocompatibility complex class I gene repertoire was investigated in a large panel of rhesus macaques of Chinese origin...
  13. Yap M, Nisole S, Lynch C, Stoye J. Trim5alpha protein restricts both HIV-1 and murine leukemia virus. Proc Natl Acad Sci U S A. 2004;101:10786-91 pubmed
    ..Recently, Trim5alpha protein from rhesus monkey was found to restrict HIV-1...
  14. Laguette N, Rahm N, Sobhian B, Chable Bessia C, M nch J, Snoeck J, et al. Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein. Cell Host Microbe. 2012;11:205-17 pubmed publisher
    ..The distinct evolutionary signature of SAMHD1 sheds light on the development of its antiviral specificity...
  15. Javanbakht H, Yuan W, Yeung D, Song B, Diaz Griffero F, Li Y, et al. Characterization of TRIM5alpha trimerization and its contribution to human immunodeficiency virus capsid binding. Virology. 2006;353:234-46 pubmed
    ..Therefore, TRIM5alpha trimerization makes a major contribution to its avidity for the retroviral capsid, and to the ability to restrict virus infection. ..
  16. Sakuma R, Noser J, Ohmine S, Ikeda Y. Rhesus monkey TRIM5alpha restricts HIV-1 production through rapid degradation of viral Gag polyproteins. Nat Med. 2007;13:631-5 pubmed
    ..Tripartite motif-containing 5 isoform-alpha (TRIM5alpha) protein from rhesus monkey (TRIM5alpharh) restricts human immunodeficiency virus type 1 (HIV-1) infection at a postentry, preintegration ..
  17. Suter M, Bocock P, Showalter L, Hu M, Shope C, McKnight R, et al. Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates. FASEB J. 2011;25:714-26 pubmed publisher
    ..In summary, the data suggest that peripheral Npas2 expression is uniquely vulnerable to diet exposure. ..
  18. Lim S, Chan T, Gelman R, Whitney J, O Brien K, Barouch D, et al. Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. PLoS Genet. 2010;6:e1000997 pubmed publisher
    ..between CCL3L CNV and clinical sequelae of the simian immunodeficiency virus (SIV) infection in vivo in rhesus monkeys. The present study was initiated to explore the possibility of an association of CCL3L CNV with the control of ..
  19. Zhang X, Goodsell J, Norgren R. Limitations of the rhesus macaque draft genome assembly and annotation. BMC Genomics. 2012;13:206 pubmed publisher
    ..Thus, investigators studying many species must rely on draft genomes. Using the rhesus macaque as an example, we document the effects of sequencing errors, gaps in sequence and misassemblies on one ..
  20. Bals R, Lang C, Weiner D, Vogelmeier C, Welsch U, Wilson J. Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules. Clin Diagn Lab Immunol. 2001;8:370-5 pubmed publisher
    ..The present study demonstrates that beta-defensins and cathelicidins of rhesus monkeys are close homologues to the human molecules and indicate that nonhuman primates represent valid model ..
  21. Fr hlich O, Ibrahim N, Young L. EP2 splicing variants in rhesus monkey (Macaca mulatta) epididymis. Biol Reprod. 2003;69:294-300 pubmed publisher
    The expression pattern of EP2 variants was examined in the rhesus monkey (Macaca mulatta)...
  22. Ortmeyer H, Adall Y, Marciani K, Katsiaras A, Ryan A, Bodkin N, et al. Skeletal muscle glycogen synthase subcellular localization: effects of insulin and PPAR-alpha agonist (K-111) administration in rhesus monkeys. Am J Physiol Regul Integr Comp Physiol. 2005;288:R1509-17 pubmed
  23. Andersen H, Rossio J, Coalter V, Poore B, Martin M, Carrington M, et al. Characterization of rhesus macaque natural killer activity against a rhesus-derived target cell line at the single-cell level. Cell Immunol. 2004;231:85-95 pubmed
    Natural killer (NK) cells and NK cell activities in the rhesus macaque have been incompletely characterized...
  24. Clark N, Swanson W. Pervasive adaptive evolution in primate seminal proteins. PLoS Genet. 2005;1:e35 pubmed publisher
  25. Windsor Engnell B, Kasuya E, Mizuno M, Keen K, Terasawa E. An increase in in vivo release of LHRH and precocious puberty by posterior hypothalamic lesions in female rhesus monkeys (Macaca mulatta). Am J Physiol Endocrinol Metab. 2007;292:E1000-9 pubmed publisher
    ..Six prepubertal female rhesus monkeys (17.4 +/- 0.1 mo of age) received lesions in the PH, three prepubertal females (17.5 +/- 0...
  26. Sawyer S, Emerman M, Malik H. Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals. PLoS Pathog. 2007;3:e197 pubmed publisher
    ..Astonishingly, this same loop is under positive selection in the multiple cow TRIM5 genes as well, indicating that this small structural loop may be a viral recognition motif spanning a hundred million years of mammalian evolution...
  27. Glausier J, Maddox M, Hemmings H, Nairn A, Greengard P, Muly E. Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex. Neuroscience. 2010;167:428-38 pubmed publisher
    ..microscopy to quantitatively determine the localization of DARPP-32 and I-1 in the neuropil of the rhesus monkey PFC...
  28. Kruse P, Rosner C, Walter L. Characterization of rhesus macaque KIR genotypes and haplotypes. Immunogenetics. 2010;62:281-93 pubmed publisher
    ..b>Rhesus macaques are often used as important animal models of human diseases such as, e.g. AIDS...
  29. Blokhuis J, van der Wiel M, Doxiadis G, Bontrop R. The mosaic of KIR haplotypes in rhesus macaques. Immunogenetics. 2010;62:295-306 pubmed publisher
    To further refine and improve biomedical research in rhesus macaques, it is necessary to increase our knowledge concerning both the degree of allelic variation (polymorphism) and diversity (gene copy number variation) in the killer cell ..
  30. Rosner C, Kruse P, Hermes M, Otto N, Walter L. Rhesus macaque inhibitory and activating KIR3D interact with Mamu-A-encoded ligands. J Immunol. 2011;186:2156-63 pubmed publisher
    ..interactions between killer cell Ig-like receptors (KIRs) and MHC class I ligands have not been described in rhesus macaques despite their importance in biomedical research...
  31. Lim E, Fregoso O, McCoy C, Matsen F, Malik H, Emerman M. The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe. 2012;11:194-204 pubmed publisher
    ..We conclude that vpr neofunctionalized to degrade SAMHD1 even prior to the birth of a separate vpx gene, thereby initiating an evolutionary arms race with SAMHD1...
  32. Kouprina N, Pavlicek A, Mochida G, Solomon G, Gersch W, Yoon Y, et al. Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion. PLoS Biol. 2004;2:E126 pubmed publisher
    ..the complete ASPM gene, including promoter regions and introns, from chimpanzee, gorilla, orangutan, and rhesus macaque by transformation-associated recombination cloning in yeast...
  33. Avellar M, Honda L, Hamil K, Yenugu S, Grossman G, Petrusz P, et al. Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta). Biol Reprod. 2004;71:1453-60 pubmed publisher
    ..article, the expression of EP2 variants was profiled in different tissues from the human and rhesus monkey (Macaca mulatta) male reproductive tract using reverse transcriptase-polymerase chain reaction...
  34. Bonnaud B, Beliaeff J, Bouton O, Oriol G, Duret L, Mallet F. Natural history of the ERVWE1 endogenous retroviral locus. Retrovirology. 2005;2:57 pubmed
    ..The encoded Env protein (Syncytin) is involved in hominoid placental physiology...
  35. Maness N, Yant L, Chung C, Loffredo J, Friedrich T, Piaskowski S, et al. Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques. J Virol. 2008;82:5245-54 pubmed publisher
    ..However, possession of favorable alleles does not guarantee improved prognosis or viral control. In rhesus macaques, the MHC-I allele Mamu-B*17 is correlated with reduced viremia and is overrepresented in macaques that ..
  36. McDaniel P, Wu X. Identification of oocyte-selective NLRP genes in rhesus macaque monkeys (Macaca mulatta). Mol Reprod Dev. 2009;76:151-9 pubmed publisher
    ..14 NLRP gene homologues and examined their spatial and temporal expression in rhesus macaque monkeys (Macaca mulatta)...
  37. Nguyen D, Scinicariello F, Attanasio R. Characterization and allelic polymorphisms of rhesus macaque (Macaca mulatta) IgG Fc receptor genes. Immunogenetics. 2011;63:351-62 pubmed publisher
    ..Indeed, initial development of HIV-1 vaccines relies heavily on simian immunodeficiency virus-infected rhesus macaques. Neutralizing antibodies, a major component of anti-HIV protective responses, ultimately interact with Fc ..
  38. Winegar D, Brown P, Wilkison W, Lewis M, Ott R, Tong W, et al. Effects of fenofibrate on lipid parameters in obese rhesus monkeys. J Lipid Res. 2001;42:1543-51 pubmed
    ..The spontaneously obese rhesus monkey is a well-recognized animal model for the study of human obesity and type 2 diabetes, and many of these ..
  39. Doxiadis G, Otting N, de Groot N, de Groot N, Rouweler A, Noort R, et al. Evolutionary stability of MHC class II haplotypes in diverse rhesus macaque populations. Immunogenetics. 2003;55:540-51 pubmed
    A thoroughly characterized breeding colony of 172 pedigreed rhesus macaques was used to analyze exon 2 of the polymorphic Mamu- DPB1, -DQA1, -DQB1, and - DRB loci...
  40. Ortiz M, Bleiber G, Martinez R, Kaessmann H, Telenti A. Patterns of evolution of host proteins involved in retroviral pathogenesis. Retrovirology. 2006;3:11 pubmed publisher
    ..The strong sequence conservation of the TRIM19/PML sequences among primates suggests that this gene does not play a role in antiretroviral defense...
  41. Hoffman J, Kaplan J, Kinkead B, Berga S, Wilson M. Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta). Endocrine. 2007;31:202-11 pubmed
    ..016) in terms of plasma cortisol than were l/l females. These data indicate that adult female rhesus monkeys with the s-variant polymorphism in the SERT gene exhibit metabolic and reproductive alterations in conjunction ..
  42. Watakabe A, Komatsu Y, Sadakane O, Shimegi S, Takahata T, Higo N, et al. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Cereb Cortex. 2009;19:1915-28 pubmed publisher
    ..The 5-HT2A agonist showed opposite effects. These results suggest that this serotonergic system controls the visual response in V1 for optimization of information processing toward the incoming visual inputs. ..
  43. Diaz Griffero F, Qin X, Hayashi F, Kigawa T, Finzi A, Sarnak Z, et al. A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction. J Virol. 2009;83:10737-51 pubmed publisher
    ..2(SPRY) domains. The TRIM5alpha(rh) protein from rhesus monkeys recognizes the human immunodeficiency virus type 1 (HIV-1) capsid as it enters the host cell and blocks virus ..
  44. Eswarappa S, Potdar A, Koch W, Fan Y, Vasu K, Lindner D, et al. Programmed translational readthrough generates antiangiogenic VEGF-Ax. Cell. 2014;157:1605-18 pubmed publisher
    ..Furthermore, genome-wide analysis revealed AGO1 and MTCH2 as authentic readthrough targets. Overall, our studies reveal a novel protein-regulated PTR event in a vertebrate system. ..
  45. Diaz Griffero F, Gallo D, Hope T, Sodroski J. Trafficking of some old world primate TRIM5? proteins through the nucleus. Retrovirology. 2011;8:38 pubmed publisher
    ..Here we report that the TRIM5? proteins of two Old World primates, humans and rhesus monkeys, are transported into the nucleus and are shuttled back to the cytoplasm by a leptomycin B-sensitive mechanism...
  46. Gibbs R, Rogers J, Katze M, Bumgarner R, Weinstock G, Mardis E, et al. Evolutionary and biomedical insights from the rhesus macaque genome. Science. 2007;316:222-34 pubmed
    The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago...
  47. Vallender E. Bioinformatic approaches to identifying orthologs and assessing evolutionary relationships. Methods. 2009;49:50-5 pubmed publisher
    ..Through these steps any researcher seeking to make use of non-human primate genetic information will have the tools at their disposal to ascertain where errors exist and to remedy them once encountered. ..
  48. Reszka N, Zhou C, Song B, Sodroski J, Knipe D. Simian TRIM5alpha proteins reduce replication of herpes simplex virus. Virology. 2010;398:243-50 pubmed publisher
    ..that several simian TRIM5alpha proteins can restrict HSV replication, with the TRIM5alpha protein of rhesus macaques showing the strongest inhibition of HSV infection...
  49. Kirmaier A, Wu F, Newman R, Hall L, Morgan J, O Connor S, et al. TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species. PLoS Biol. 2010;8: pubmed publisher
    ..source of multiple, successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in rhesus macaques, and SIVstm in stump-tailed macaques...
  50. Yeh W, Rao S, Lim S, Zhang J, Hraber P, Brassard L, et al. The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys. J Virol. 2011;85:10389-98 pubmed publisher
    ..TRIM5 may also contribute to susceptibility to mucosal acquisition of simian immunodeficiency virus (SIV) in rhesus monkeys. We explored this hypothesis by establishing 3 cohorts of Indian-origin rhesus monkeys with different TRIM5 ..
  51. Francis P, Appukuttan B, Simmons E, Landauer N, Stoddard J, Hamon S, et al. Rhesus monkeys and humans share common susceptibility genes for age-related macular disease. Hum Mol Genet. 2008;17:2673-80 pubmed publisher
    ..We genotyped a cohort of 137 unrelated rhesus macaques with and without macular drusen...
  52. Yearley J, Xia D, Pearson C, Carville A, Shannon R, Mansfield K. Interleukin-18 predicts atherosclerosis progression in SIV-infected and uninfected rhesus monkeys (Macaca mulatta) on a high-fat/high-cholesterol diet. Lab Invest. 2009;89:657-67 pubmed publisher
    ..Acutely simian immunodeficiency virus-infected and uninfected rhesus monkeys (Macaca mulatta) on an atherogenic diet were evaluated prospectively for atherosclerotic lesion development ..
  53. Uno Y, Matsushita A, Osada N, Uehara S, Kohara S, Nagata R, et al. Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques. Drug Metab Dispos. 2010;38:209-14 pubmed publisher
    Cynomolgus and rhesus macaques are frequently used in preclinical trials due to their close evolutionary relationships to humans...
  54. Pacheco B, Finzi A, Stremlau M, Sodroski J. Adaptation of HIV-1 to cells expressing rhesus monkey TRIM5?. Virology. 2010;408:204-12 pubmed publisher
    ..We adapted an HIV-1 isolate to replicate in cells expressing TRIM5?(rh) from rhesus monkeys, an Old World species...
  55. Neddens J, Buonanno A. Expression of the neuregulin receptor ErbB4 in the brain of the rhesus monkey (Macaca mulatta). PLoS ONE. 2011;6:e27337 pubmed publisher
    ..This interpretation is functionally consistent with the genetic association of NRG1 and ERBB4 with schizophrenia...
  56. Kjeldbjerg A, Villesen P, Aagaard L, Pedersen F. Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution. BMC Evol Biol. 2008;8:266 pubmed publisher
    ..Together with the placenta-specific expression of the human and baboon ENVV1 and ENVV2 envelope genes, these data provide strong evidence of a beneficial role for the host. ..
  57. Bostik P, Kobkitjaroen J, Tang W, Villinger F, Pereira L, Little D, et al. Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immunodeficiency virus-infected rhesus macaques with high viral loads. J Immunol. 2009;182:3638-49 pubmed publisher
    ..In the SIV-infected rhesus macaque (RM) model of AIDS, several families of killer inhibitory Ig-related receptors (KIR receptors) corresponding ..
  58. Zhang F, Wilson S, Landford W, Virgen B, Gregory D, Johnson M, et al. Nef proteins from simian immunodeficiency viruses are tetherin antagonists. Cell Host Microbe. 2009;6:54-67 pubmed publisher
  59. Lim S, Rogers T, Chan T, Whitney J, Kim J, Sodroski J, et al. TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys. PLoS Pathog. 2010;6:e1000738 pubmed publisher
    ..of retroviral infection in a susceptible host species, we investigated the impact of TRIM5 polymorphisms in rhesus monkeys on the course of a simian immunodeficiency virus (SIV) infection...
  60. Uno Y, Fujino H, Iwasaki K, Utoh M. Macaque CYP2C76 encodes cytochrome P450 enzyme not orthologous to any human isozymes. Curr Drug Metab. 2010;11:142-52 pubmed
    ..In this assessment, we found the CYP2C76 cDNA sequence in rhesus monkey, and a gene sequence highly homologous to cynomolgus monkey CYP2C76 in the marmoset and orangutan genomes, ..
  61. Wahab F, Bano R, Jabeen S, Irfan S, Shahab M. Effect of peripheral kisspeptin administration on adiponectin, leptin, and resistin secretion under fed and fasting conditions in the adult male rhesus monkey (Macaca mulatta). Horm Metab Res. 2010;42:570-4 pubmed publisher
    ..namely, adiponectin, leptin, and resistin in a set of four chair-restraint habituated intact adult male rhesus monkeys under; 1) normal fed conditions, 2) 24-h fasting conditions, and 3) 48-h fasting conditions...
  62. Vrang N, Grove K. The brainstem preproglucagon system in a non-human primate (Macaca mulatta). Brain Res. 2011;1397:28-37 pubmed publisher
    ..The findings indicate that the brainstem preproglucagon neuronal system is highly conserved between rat and non-human primate with the exception of a much denser innervation of the mediobasal hypothalamus in the primate brain...
  63. Brandariz Nuñez A, Roa A, Valle Casuso J, Biris N, Ivanov D, Diaz Griffero F. Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5?. Virology. 2013;435:463-71 pubmed publisher
    ..Overall, our results do not support a role for SIMs or SUMOylation in the antiviral properties of TRIM5?. ..
  64. Leonova L, Kokryakov V, Aleshina G, Hong T, Nguyen T, Zhao C, et al. Circular minidefensins and posttranslational generation of molecular diversity. J Leukoc Biol. 2001;70:461-4 pubmed
    We purified two new minidefensins (RTD-2 and RTD-3) from the bone marrow of rhesus monkeys. Both were circular octadecapeptides that contained three intramolecular disulfide bonds and were homologous to RTD-1, a circular (theta) defensin ..
  65. Matsunaga T, Ohmori S, Ishida M, Sakamoto Y, Nakasa H, Kitada M. Molecular cloning of monkey CYP2C43 cDNA and expression in yeast. Drug Metab Pharmacokinet. 2002;17:117-24 pubmed
    A cDNA clone designated as CYP2C43 was isolated from the rhesus monkey liver cDNA library...
  66. Shibata M, Friedman R, Ramaswamy S, Plant T. Evidence that down regulation of hypothalamic KiSS-1 expression is involved in the negative feedback action of testosterone to regulate luteinising hormone secretion in the adult male rhesus monkey (Macaca mulatta). J Neuroendocrinol. 2007;19:432-8 pubmed publisher
    ..To this end, 12 castrated adult male rhesus monkeys were implanted with either testosterone containing or empty Silastic capsules...
  67. Wang J, Tan W, Chen Y, Lu X, Lu Y, Qin S, et al. Full-length cDNA cloning and protein three-dimensional structure modeling of factor VII of rhesus monkey, Macaca mulatta. Blood Cells Mol Dis. 2008;40:237-43 pubmed
    ..In this paper, we report the full-length cDNA sequences of rhesus monkey FVII...
  68. Campbell E, Perez O, Anderson J, Hope T. Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5alpha. J Cell Biol. 2008;180:549-61 pubmed publisher
    ..However, the underlying restriction mechanism remains unclear. In this study, we show that during rhesus macaque TRIM5alpha (rhTRIM5alpha)-mediated restriction of HIV-1 infection, cytoplasmic HIV-1 viral complexes can ..
  69. Ma X, Tang L, Qu L, Ma J, Chen L. Identification of 17 novel major histocompatibility complex-A alleles in a population of Chinese-origin rhesus macaques. Tissue Antigens. 2009;73:184-7 pubmed publisher
    b>Rhesus macaques (Macaca mulatta) serve as important animal models for human disease and vaccine research...
  70. BLACK L, Aiken C. TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitro. J Virol. 2010;84:6564-9 pubmed publisher
    ..A previous study reported that rhesus macaque TRIM5alpha protein stably associates with cylindrical complexes formed by assembly of recombinant HIV-1 CA-NC ..
  71. Wahab F, Ullah F, Chan Y, Seminara S, Shahab M. Decrease in hypothalamic Kiss1 and Kiss1r expression: a potential mechanism for fasting-induced suppression of the HPG axis in the adult male rhesus monkey (Macaca mulatta). Horm Metab Res. 2011;43:81-5 pubmed publisher
    ..In addition, our finding of lower expression of KISS1R in fasted monkeys provides an explanation for the attenuation in the HPG axis response to peripheral kisspeptin challenge during short-term fasting...
  72. Zhao G, Ke D, Vu T, Ahn J, Shah V, Yang R, et al. Rhesus TRIM5? disrupts the HIV-1 capsid at the inter-hexamer interfaces. PLoS Pathog. 2011;7:e1002009 pubmed publisher
    ..b>Rhesus macaque TRIM5? (TRIM5?(rh)) targets the HIV-1 capsid and blocks infection at an early post-entry stage, prior to ..
  73. Ungvari Z, Bailey Downs L, Gautam T, Sosnowska D, Wang M, Monticone R, et al. Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta. J Gerontol A Biol Sci Med Sci. 2011;66:866-75 pubmed publisher
    ..We found that carotid arteries of aged rhesus macaques (Macaca mulatta, age: ?20 years) exhibit significant oxidative stress (as indicated by the increased 8-iso-..
  74. Li X, Yeung D, Fiegen A, Sodroski J. Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins. J Biol Chem. 2011;286:27959-70 pubmed publisher
    ..These results support a model in which both ends of the core TRIM dimer (RING-B-box 2 at one end and Linker 2 at the other) contribute to the formation of higher order arrays. ..
  75. Patel M, Loo Y, Horner S, Gale M, Malik H. Convergent evolution of escape from hepaciviral antagonism in primates. PLoS Biol. 2012;10:e1001282 pubmed publisher
    ..Our analyses also provide a means by which primates might clear infections by extant hepaciviruses like HCV...
  76. Solomon C, Southwood S, Hoof I, Rudersdorf R, Peters B, Sidney J, et al. The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype. Immunogenetics. 2010;62:451-64 pubmed publisher
    ..potentially being a more relevant model for AIDS outcomes than the Indian rhesus macaque, the Chinese-origin rhesus macaques have not been well-characterized for their major histocompatibility complex (MHC) composition and function, ..
  77. Herv C, Forrest G, L wer R, Griffiths D, Venables P. Conservation and loss of the ERV3 open reading frame in primates. Genomics. 2004;83:940-3 pubmed publisher
    ..18% identical to that of human. In other species the identity falls (93.71% in rhesus macaque) in proportion to the separation from the human lineage...
  78. de Groot N, Doxiadis G, de Groot N, Otting N, Heijmans C, Rouweler A, et al. Genetic makeup of the DR region in rhesus macaques: gene content, transcripts, and pseudogenes. J Immunol. 2004;172:6152-7 pubmed
    In the human population, five major HLA-DRB haplotypes have been identified, whereas the situation in rhesus macaques (Macaca mulatta) is radically different...
  79. Karl J, Wiseman R, Campbell K, Blasky A, Hughes A, Ferguson B, et al. Identification of MHC class I sequences in Chinese-origin rhesus macaques. Immunogenetics. 2008;60:37-46 pubmed
    ..exhibiting distinctive morphological and physiological characteristics, Indian- and Chinese-origin rhesus macaques, are commonly used in research...
  80. Paulmann D, Magulski T, Schwarz R, Heitmann L, Flehmig B, Vallbracht A, et al. Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation. J Gen Virol. 2008;89:1593-604 pubmed publisher
    ..This ability might be of vital importance for HAV, which is an exceptionally slow growing virus sensitive to IFN-beta, as it allows the virus to establish infection and maintain virus replication for a longer period of time...
  81. Blokhuis J, van der Wiel M, Doxiadis G, Bontrop R. Evidence for balancing selection acting on KIR2DL4 genotypes in rhesus macaques of Indian origin. Immunogenetics. 2009;61:503-12 pubmed publisher
    ..In both humans and rhesus macaques, particular types of non-classical MHC class I molecules are predominantly expressed on the trophoblast...
  82. Wohlford Lenane C, Meyerholz D, Perlman S, Zhou H, Tran D, Selsted M, et al. Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease. J Virol. 2009;83:11385-90 pubmed publisher
    ..RTD-1-treated, SARS-CoV-infected mice displayed altered lung tissue cytokine responses 2 and 4 days postinfection compared to those of untreated animals, suggesting that one possible mechanism of action for RTD-1 is immunomodulatory. ..
  83. O CONNOR C, Pertel T, Gray S, Robia S, Bakowska J, Luban J, et al. p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. J Virol. 2010;84:5997-6006 pubmed publisher
    ..to the cross-species transmission of retroviruses, the most well known being the TRIM5alpha protein from rhesus macaques, which potently inhibits human immunodeficiency virus type 1 (HIV-1) infection...
  84. Biris N, Yang Y, Taylor A, Tomashevski A, Guo M, Hart P, et al. Structure of the rhesus monkey TRIM5? PRYSPRY domain, the HIV capsid recognition module. Proc Natl Acad Sci U S A. 2012;109:13278-83 pubmed publisher
    ..2/PRYSPRY domain. Here we report a high-resolution structure of a TRIM5? PRYSPRY domain, the PRYSPRY of the rhesus monkey TRIM5? that potently restricts HIV infection, and identify features involved in its interaction with the HIV ..
  85. Ohkura S, Stoye J. A comparison of murine leukemia viruses that escape from human and rhesus macaque TRIM5?s. J Virol. 2013;87:6455-68 pubmed publisher
    ..to retrovirus capsid, we had previously selected N-tropic murine leukemia virus (N-MLV) mutants escaping from rhesus macaque TRIM5? (rhTRIM5?) by passaging the virus in rhTRIM5?-expressing cells and selecting for nonrestricted variants...
  86. Wilson S, Webb B, Ylinen L, Verschoor E, Heeney J, Towers G. Independent evolution of an antiviral TRIMCyp in rhesus macaques. Proc Natl Acad Sci U S A. 2008;105:3557-62 pubmed publisher
    ..Here, we show that the Old World monkey, rhesus macaque (Macaca mulatta), also encodes a TRIMCyp protein that has arisen independently from that in owl monkeys...
  87. Jia B, Serra Moreno R, Neidermyer W, Rahmberg A, Mackey J, Fofana I, et al. Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2. PLoS Pathog. 2009;5:e1000429 pubmed publisher
    ..These results identify Nef as the viral gene product of SIV that opposes restriction by tetherin in rhesus macaques and sooty mangabeys, and reveal species-specificity in the activities of both Nef and Vpu in overcoming ..
  88. Chaichompoo P, Bostik P, Stephenson S, Udompunturuk S, Kobkitjaroen J, Pattanapanyasat K, et al. Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques. Cell Immunol. 2010;263:176-87 pubmed publisher
    ..shown an association of KIR3DL alleles 13 and 14 with high plasma viral loads in a cohort of SIV-infected rhesus macaques. To gain a more detailed understanding of the role of KIR polymorphisms, our laboratory herein conducted ..
  89. Colantonio A, Bimber B, Neidermyer W, Reeves R, Alter G, Altfeld M, et al. KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif. PLoS Pathog. 2011;7:e1001316 pubmed publisher
    ..Here we identify Mamu-A1*00201 (Mamu-A*02), a common MHC class I molecule in the rhesus macaque with a canonical Bw6 motif, as a ligand for Mamu-KIR3DL05...
  90. Shi L, Su B. Identification and functional characterization of a primate-specific E2F1 binding motif regulating MCPH1 expression. FEBS J. 2012;279:491-503 pubmed publisher
    ..Database The MCPH1 promoter region was sequenced in human, chimpanzee and rhesus macaque. Nucleotide sequence data are available in the GenBank database (http://www.ncbi.nlm.nih...
  91. Yamaguchi Y, Hayashi A, Campagnoni C, Kimura A, Inuzuka T, Baba H. L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough. J Biol Chem. 2012;287:17765-76 pubmed publisher
    ..Since this is the first finding of stop codon readthrough in a common mammalian protein, detailed analysis of L-MPZ expression will help to understand the mechanism of stop codon readthrough in mammals. ..
  92. Compton A, Emerman M. Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses. PLoS Pathog. 2013;9:e1003135 pubmed publisher
    ..Our analysis of virus-driven evolution describes an ancient yet ongoing genetic conflict between simian primates and lentiviruses on a million-year time scale...