crab-eating macaque

Summary

Alias: crab eating macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque, Macaca fascicularis, Macaca cynomolgus, Macaca irus

Top Publications

  1. Saito Y, Naruse T, Akari H, Matano T, Kimura A. Diversity of MHC class I haplotypes in cynomolgus macaques. Immunogenetics. 2012;64:131-41 pubmed publisher
    ..Family studies revealed that there were two haplotypes which contained two Mafa-A1 alleles. These observations demonstrated further the complexity of MHC class I locus in the Old World monkey...
  2. Laguette N, Rahm N, Sobhian B, Chable Bessia C, M nch J, Snoeck J, et al. Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein. Cell Host Microbe. 2012;11:205-17 pubmed publisher
    ..The distinct evolutionary signature of SAMHD1 sheds light on the development of its antiviral specificity...
  3. Komori M, Kikuchi O, Sakuma T, Funaki J, Kitada M, Kamataki T. Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450. Biochim Biophys Acta. 1992;1171:141-6 pubmed
    ..The deduced amino acid sequences of four monkey cytochrome P-450 cDNAs, including P450 1A1 (MKah1) which we isolated previously, were more than 92% identical with those of corresponding human cytochrome P-450 cDNAs. ..
  4. Urvater J, Otting N, Loehrke J, Rudersdorf R, Slukvin I, Piekarczyk M, et al. Mamu-I: a novel primate MHC class I B-related locus with unusually low variability. J Immunol. 2000;164:1386-98 pubmed
    ..Additionally, no evidence for positive selection on the peptide binding region was observed. Together, these results suggest that Mamu-I is an MHC class I locus in primates that has features of both classical and nonclassical loci. ..
  5. Del Pero M, Boniotto M, Zuccon D, Cervella P, Spano A, Amoroso A, et al. Beta-defensin 1 gene variability among non-human primates. Immunogenetics. 2002;53:907-13 pubmed
    ..Compared with these taxa, hylobatids and cercopithecids exhibit 3-4 amino acid substitutions, some of which increase the net charge of the active molecule. ..
  6. Osada N, Kusuda J, Hirata M, Tanuma R, Hida M, Sugano S, et al. Search for genes positively selected during primate evolution by 5'-end-sequence screening of cynomolgus monkey cDNAs. Genomics. 2002;79:657-62 pubmed
    ..during primate evolution by using 5'-end sequences of 21,302 clones derived from cynomolgus monkey (Macaca fascicularis) brain cDNA libraries...
  7. Dorus S, Evans P, Wyckoff G, Choi S, Lahn B. Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity. Nat Genet. 2004;36:1326-9 pubmed publisher
    ..Our study showcases the intimate relationship between sexual selection and the molecular evolution of reproductive genes...
  8. Uda A, Tanabayashi K, Fujita O, Hotta A, Terao K, Yamada A. Identification of the MHC class I B locus in cynomolgus monkeys. Immunogenetics. 2005;57:189-97 pubmed
    By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified...
  9. O Connor S, Blasky A, Pendley C, Becker E, Wiseman R, Karl J, et al. Comprehensive characterization of MHC class II haplotypes in Mauritian cynomolgus macaques. Immunogenetics. 2007;59:449-62 pubmed
    ..showed that six common MHC haplotypes account for essentially all MHC diversity in cynomolgus macaques (Macaca fascicularis) from the island of Mauritius...

More Information

Publications292 found, 100 shown here

  1. Uno Y, Suzuki Y, Wakaguri H, Sakamoto Y, Sano H, Osada N, et al. Expressed sequence tags from cynomolgus monkey (Macaca fascicularis) liver: a systematic identification of drug-metabolizing enzymes. FEBS Lett. 2008;582:351-8 pubmed publisher
    ..To provide such a genetic resource, 28655 expressed sequence tags (ESTs) were generated from a cynomolgus monkey liver full-length enriched cDNA library, which contained 23 unique ESTs homologous to human drug-..
  2. Osada N, Hashimoto K, Kameoka Y, Hirata M, Tanuma R, Uno Y, et al. Large-scale analysis of Macaca fascicularis transcripts and inference of genetic divergence between M. fascicularis and M. mulatta. BMC Genomics. 2008;9:90 pubmed publisher
    Cynomolgus macaques (Macaca fascicularis) are widely used as experimental animals in biomedical research and are closely related to other laboratory macaques, such as rhesus macaques (M. mulatta)...
  3. Pendley C, Becker E, Karl J, Blasky A, Wiseman R, Hughes A, et al. MHC class I characterization of Indonesian cynomolgus macaques. Immunogenetics. 2008;60:339-51 pubmed publisher
    Cynomolgus macaques (Macaca fascicularis) are quickly becoming a useful model for infectious disease and transplantation research...
  4. Campbell K, Detmer A, Karl J, Wiseman R, Blasky A, Hughes A, et al. Characterization of 47 MHC class I sequences in Filipino cynomolgus macaques. Immunogenetics. 2009;61:177-87 pubmed publisher
    Cynomolgus macaques (Macaca fascicularis) provide increasingly common models for infectious disease research...
  5. Kita Y, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, et al. MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque. Immunogenetics. 2009;61:635-48 pubmed publisher
    Cynomolgus macaques (Macaca fascicularis, Mafa) have emerged as important animal models for biomedical research, necessitating a more extensive characterization of their major histocompatibility complex polymorphic regions...
  6. Wiseman R, Karl J, Bimber B, O Leary C, Lank S, Tuscher J, et al. Major histocompatibility complex genotyping with massively parallel pyrosequencing. Nat Med. 2009;15:1322-6 pubmed publisher
    ..The remarkable sensitivity of this approach in macaques demonstrates that pyrosequencing is viable for ultra-high-throughput MHC genotyping of primates, including humans...
  7. Otting N, Doxiadis G, Bontrop R. Definition of Mafa-A and -B haplotypes in pedigreed cynomolgus macaques (Macaca fascicularis). Immunogenetics. 2009;61:745-53 pubmed publisher
    ..Furthermore, the discovery of 53 unreported Mafa-B sequences expands the lexicon of alleles significantly, and may help in understanding the complex organisation of the macaque B region. ..
  8. Creager H, Becker E, Sandman K, Karl J, Lank S, Bimber B, et al. Characterization of full-length MHC class II sequences in Indonesian and Vietnamese cynomolgus macaques. Immunogenetics. 2011;63:611-8 pubmed publisher
  9. Doxiadis G, de Vos Rouweler A, de Groot N, Otting N, Bontrop R. DR haplotype diversity of the cynomolgus macaque as defined by its transcriptome. Immunogenetics. 2012;64:31-7 pubmed publisher
    ..To date, however, the DR region of cynomolgus macaques (Macaca fascicularis) has been poorly defined...
  10. Mitchell P, Patzina C, Emerman M, Haller O, Malik H, Kochs G. Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA. Cell Host Microbe. 2012;12:598-604 pubmed publisher
    ..Taken together, our findings identify a genetic determinant of MxA target recognition and suggest a model by which MxA achieves antiviral breadth without compromising viral specificity...
  11. Osada N, Hida M, Kusuda J, Tanuma R, Hirata M, Hirai M, et al. Prediction of unidentified human genes on the basis of sequence similarity to novel cDNAs from cynomolgus monkey brain. Genome Biol. 2002;3:RESEARCH0006 pubmed
    ..full-length cDNAs as orthologs of unidentified human genes from cDNA libraries of the cynomolgus monkey (Macaca fascicularis) brain (parietal lobe and cerebellum)...
  12. Krebs K, Jin Z, Rudersdorf R, Hughes A, O Connor D. Unusually high frequency MHC class I alleles in Mauritian origin cynomolgus macaques. J Immunol. 2005;175:5230-9 pubmed
    ..primates suitable for studies of cellular immunity, we defined 66 MHC I alleles in Cynomolgus macaques (Macaca fascicularis) of Chinese, Vietnamese, and Mauritian origin...
  13. Marshall D, Rudnick K, Lu J, Snyder L. Cloning and sequencing of the cynomolgus monkey prostate specific antigen cDNA. J Med Primatol. 2006;35:12-7 pubmed
    ..We wanted to assess the usefulness of the cynomolgus monkey (Macaca fascicularis) as a relevant animal model to evaluate PSA-specific therapies...
  14. Blancher A, Tisseyre P, Dutaur M, Apoil P, Maurer C, Quesniaux V, et al. Study of Cynomolgus monkey (Macaca fascicularis) MhcDRB (Mafa-DRB) polymorphism in two populations. Immunogenetics. 2006;58:269-82 pubmed
    ..we characterized 50 exon 2 sequences among which 28 were identical to sequences already reported in Macaca fascicularis or other macaque species (Macaca mulatta, Macaca nemestrina)...
  15. Chen W, Wang X, Lin W, He X, Wu Z, Lin Y, et al. Analysis of 10,000 ESTs from lymphocytes of the cynomolgus monkey to improve our understanding of its immune system. BMC Genomics. 2006;7:82 pubmed
    The cynomolgus monkey (Macaca fascicularis) is one of the most widely used surrogate animal models for an increasing number of human diseases and vaccines, especially immune-system-related ones...
  16. Uno Y, Fujino H, Kito G, Kamataki T, Nagata R. CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone. Mol Pharmacol. 2006;70:477-86 pubmed
    ..In this study, we report identification of the CYP2C76 cDNA newly identified in cynomolgus monkey and characterization of this CYP2C along with cynomolgus CYP2C20, CYP2C43, and CYP2C75...
  17. Wiseman R, Wojcechowskyj J, Greene J, Blasky A, Gopon T, Soma T, et al. Simian immunodeficiency virus SIVmac239 infection of major histocompatibility complex-identical cynomolgus macaques from Mauritius. J Virol. 2007;81:349-61 pubmed
    ..microsatellite analysis to show that simian immunodeficiency virus (SIV)-susceptible cynomolgus macaques (Macaca fascicularis) from the Indian Ocean island of Mauritius have extremely simple MHC genetics, with six common haplotypes ..
  18. Otting N, de Vos Rouweler A, Heijmans C, de Groot N, Doxiadis G, Bontrop R. MHC class I A region diversity and polymorphism in macaque species. Immunogenetics. 2007;59:367-75 pubmed
    ..To shed light on this issue, rhesus macaques from a Chinese population and a panel of cynomolgus monkeys (Macaca fascicularis) were screened for various A region-linked variations...
  19. Bimber B, Moreland A, Wiseman R, Hughes A, O Connor D. Complete characterization of killer Ig-like receptor (KIR) haplotypes in Mauritian cynomolgus macaques: novel insights into nonhuman primate KIR gene content and organization. J Immunol. 2008;181:6301-8 pubmed
    ..The findings from this study fundamentally advance our understanding of KIR genetics in nonhuman primates and establish a foundation from which to study KIR signaling in disease pathogenesis. ..
  20. Budde M, Wiseman R, Karl J, Hanczaruk B, Simen B, O Connor D. Characterization of Mauritian cynomolgus macaque major histocompatibility complex class I haplotypes by high-resolution pyrosequencing. Immunogenetics. 2010;62:773-80 pubmed publisher
    ..Overall, this approach significantly expanded our knowledge of MCM haplotypes and will facilitate future studies on disease pathogenesis and protective cellular immunity. ..
  21. Aarnink A, Apoil P, Takahashi I, Osada N, Blancher A. Characterization of MHC class I transcripts of a Malaysian cynomolgus macaque by high-throughput pyrosequencing and EST libraries. Immunogenetics. 2011;63:703-13 pubmed publisher
    ..This study reveals that the high-throughput pyrosequencing allows not only to characterize the MHC class I transcripts but also to estimate the number of MHC class I genes in the genome of cynomolgus macaque...
  22. Ozbilgin A, Çavuş İ, Yildirim A, Gunduz C. [The first monkey malaria in Turkey: a case of Plasmodium knowlesi]. Mikrobiyol Bul. 2016;50:484-90 pubmed
    ..P.knowlesi which infects macaque monkeys (Macaca fascicularis and M.nemestrina) is transmitted to humans especially by Anopheles leucosphyrus and An.hackeri mosquitos...
  23. Wolfe B, Wiepz G, Schotzko M, Bondarenko G, Durning M, Simmons H, et al. Acute Fetal Demise with First Trimester Maternal Infection Resulting from Listeria monocytogenes in a Nonhuman Primate Model. MBio. 2017;8: pubmed publisher
    ..Four pregnant cynomolgus macaques (Macaca fascicularis) received a single intragastric inoculation between days 36 and 46 of gestation with 107 ..
  24. Yasmin L, Takano J, Sankai T. Effective use of the TSPY gene-specific copy number in determining fetal DNA in the maternal blood of cynomolgus monkeys. Anim Sci J. 2016;87:1034-40 pubmed publisher
    ..maternal blood plasma (cell-free DNA) and fractional precipitated blood cells (cellular DNA) from individual cynomolgus monkeys at 22 weeks of pregnancy...
  25. Lee A, Khiabanian H, Kugelman J, Elliott O, Nagle E, Yu G, et al. Transcriptome reconstruction and annotation of cynomolgus and African green monkey. BMC Genomics. 2014;15:846 pubmed publisher
    ..samples, we characterize the transcriptomes of two commonly used NHP animal models: Cynomolgus macaque (Macaca fascicularis) and African green monkey (Chlorocebus aethiops)...
  26. Bouskila J, Javadi P, Palmour R, Bouchard J, Ptito M. Standardized full-field electroretinography in the Green Monkey (Chlorocebus sabaeus). PLoS ONE. 2014;9:e111569 pubmed publisher
    ..Green Monkey matched very well with those in humans and other non-human primate species (Macaca mulatta and Macaca fascicularis)...
  27. Shimozawa N. Cynomolgus Monkey Induced Pluripotent Stem Cells Generated By Using Allogeneic Genes. Methods Mol Biol. 2016;1357:173-82 pubmed publisher
    ..In cynomolgus monkeys (Macaca fascicularis), iPS cells generated by using these four allogeneic transgenes should be an important resource for various ..
  28. Kishi N, Takasuka A, Kokawa Y, Isobe T, Taguchi M, Shigeyama M, et al. Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9. Xenobiotica. 2016;46:289-95 pubmed publisher
    ..4. These results demonstrated that the profiles for the hepatic and intestinal glucuronidation of raloxifene by microsomes were moderately different between humans and monkeys. ..
  29. Thompson K, Newcomb D, Moffat G, Zalikowski J, Chellman G, McNerney M. Evaluation of early fetal exposure to vaginally-administered metronidazole in pregnant cynomolgus monkeys. Reprod Toxicol. 2016;59:17-21 pubmed publisher
    ..calculations are sufficiently conservative to predict embryo-fetal exposure from drugs in semen, pregnant cynomolgus monkeys were given a vaginal dose of metronidazole during the early fetal period and cesarean-sectioned...
  30. Takahashi R, Halladay J, Siu M, Chen Y, Hop C, Khojasteh S, et al. Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450. Drug Metab Dispos. 2017;45:430-440 pubmed publisher
    ..endogenous plus drug-derived) were measured following repeated administration of GDC-0425 to rats and cynomolgus monkeys. No overt increases were observed with thiocyanate concentrations of 121-154 µM in rats and 71-110 <..
  31. Jimenez V, Allen D, McClintick M, Grant K. Social setting, social rank and HPA axis response in cynomolgus monkeys. Psychopharmacology (Berl). 2017;234:1881-1889 pubmed publisher
    ..Male cynomolgus macaques (Macaca fascicularis, n = 11) were individually (A) and socially housed (B) in alternation, over consecutive months, in an ABA ..
  32. Sahara H, Sekijima M, Ariyoshi Y, Kawai A, Miura K, Waki S, et al. Effects of carbon monoxide on early dysfunction and microangiopathy following GalT-KO porcine pulmonary xenotransplantation in cynomolgus monkeys. Xenotransplantation. 2017;: pubmed publisher
    ..In this study, we evaluated whether the perioperative treatment with low-dose inhalation of CO has beneficial effects on porcine lung xenografts in cynomolgus monkeys (cynos).
  33. Bhakta S, Crocker L, Chen Y, Hazen M, Schutten M, Li D, et al. An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer. Mol Cancer Ther. 2018;17:638-649 pubmed publisher
    ..The lead anti-GFRA1 ADC cross-reacts with rodent and cynomolgus monkey GFRA1 antigen and showed optimal pharmacokinetic properties in both species...
  34. Huang T, Yu L, Ma X, Hu K. An adapted isotope dilution 1H-13C heteronuclear single-quantum correlation (ID-HSQC) for rapid and accurate quantification of endogenous and exogenous plasma glucose. Anal Bioanal Chem. 2018;410:6705-6711 pubmed publisher
    ..for the quantification of endogenous and exogenous glucose in plasma derived from healthy and diabetic cynomolgus monkeys. The results nicely agree with our previous LC-MS/MS results...
  35. Ramharack R, Spahr M, Hicks G, Kieft K, Brammer D, Minton L, et al. Gemfibrozil significantly lowers cynomolgus monkey plasma lipoprotein[a]-protein and liver apolipoprotein[a] mRNA levels. J Lipid Res. 1995;36:1294-304 pubmed
    Eight male cynomolgus monkeys (Macaca fascicularis) on a normal chow diet were orally administered gemfibrozil daily using a weekly rising dose protocol for 3 weeks (50, 125, and 200 mg/kg per day)...
  36. Nickells R, Burgoyne C, Quigley H, Zack D. Cloning and characterization of rod opsin cDNA from the Old World monkey, Macaca fascicularis. Invest Ophthalmol Vis Sci. 1995;36:72-82 pubmed
    ..the primate family of opsins, the authors cloned and characterized the opsin cDNA for the Old World monkey Macaca fascicularis and determined its position in the phylogenetic tree of the opsin gene family...
  37. Godinot N, Iversen P, Tabas L, Xia X, Williams D, Dantzig A, et al. Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey. Mol Cancer Ther. 2003;2:307-16 pubmed
    ..similar to hMRP1, we cloned and characterized two alleles of the MRP1 homologue from the cynomolgus monkey Macaca fascicularis (monMRP1)...
  38. Cabo R, Alonso P, San José I, Vázquez G, Pastor J, Germanà A, et al. Brain-derived neurotrofic factor and its receptor TrkB are present, but segregated, within mature cutaneous Pacinian corpuscles of Macaca fascicularis. Anat Rec (Hoboken). 2015;298:624-9 pubmed publisher
    ..we analyzed expression of TrkB and their ligands BDNF and NT-4 in the cutaneous Pacinian corpuscles of Macaca fascicularis using immunohistochemistry and fluorescent microscopy...
  39. BUTT M, Evans M, Bowman C, Cummings T, Oneda S, Shelton D, et al. Morphologic, stereologic, and morphometric evaluation of the nervous system in young cynomolgus monkeys (Macaca fascicularis) following maternal administration of tanezumab, a monoclonal antibody to nerve growth factor. Toxicol Sci. 2014;142:463-76 pubmed publisher
    Tanezumab, an antibody to nerve growth factor, was administered to pregnant cynomolgus monkeys at 0, 0.5, 4, and 30 mg/kg weekly, beginning gestation day (GD) 20 through parturition (∼GD165)...
  40. Yuyama K, Sun H, Usuki S, Sakai S, Hanamatsu H, Mioka T, et al. A potential function for neuronal exosomes: sequestering intracerebral amyloid-β peptide. FEBS Lett. 2015;589:84-8 pubmed publisher
    ..We demonstrated the presence of exosome-associated Aβ in the cerebrospinal fluid (CSF) of cynomolgus monkeys and APP transgenic mice...
  41. Hamza M, Kumar C, Chia S, Anandalakshmi V, Boo N, Strapps W, et al. Alterations in the hepatic transcriptional landscape after RNAi mediated ApoB silencing in cynomolgus monkeys. Atherosclerosis. 2015;242:383-95 pubmed publisher
    ..the phenotypic effects on serum lipids with various levels of hepatic ApoB mRNA knockdown in healthy lean cynomolgus monkeys. ApoB siRNA dosed animals demonstrated significant reductions of hepatic ApoB mRNA and serum APOB protein, ..
  42. Zhao Y, Law H, Zhang Z, Lam H, Quan Q, Li G, et al. Online coupling of hydrophilic interaction/strong cation exchange/reversed-phase liquid chromatography with porous graphitic carbon liquid chromatography for simultaneous proteomics and N-glycomics analysis. J Chromatogr A. 2015;1415:57-66 pubmed publisher
    ..Our new integrated technology also exhibited excellent performance in the first N-glycomics analysis of cynomolgus monkey plasma; we successfully identified 122 proposed N-glycans and 135 N-glycosylation sites from 122 N-..
  43. Veeranagouda Y, Leonard J, Gautier J, Boitier E. Next-Generation Sequencing to Investigate Urinary microRNAs from Macaca fascicularis (Cynomolgus Monkey). Methods Mol Biol. 2017;1641:349-378 pubmed publisher
    ..an Ion Torrent's Ion Proton System, here we described miRNAs sequencing of urine samples collected from Macaca fascicularis (Cynomolgus monkey) to investigate miRNAs as potential novel biomarkers of nephrotoxicity in this species...
  44. Bowman C, Evans M, Cummings T, Oneda S, BUTT M, Hurst S, et al. Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis). Reprod Toxicol. 2015;53:105-18 pubmed publisher
    ..studies with tanezumab, an anti-nerve growth factor monoclonal antibody, were conducted in pregnant cynomolgus monkeys to assess potential effects on pregnancy and pre- and postnatal development...
  45. Coppiello G, Abizanda G, Aguado N, Iglesias E, Arellano Viera E, Rodriguez Madoz J, et al. Generation of Macaca fascicularis iPS cell line ATCi-MF1 from adult skin fibroblasts using non-integrative Sendai viruses. Stem Cell Res. 2017;21:1-4 pubmed publisher
    We generated ATCi-MF1 induced pluripotent stem (iPS) cell line from Macaca fascicularis adult skin fibroblasts using non-integrative Sendai viruses carrying OCT3/4, KLF4, SOX2 and c-MYC...
  46. Dooher J, Lingappa J. Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells. J Virol. 2004;78:1645-56 pubmed
    ..Together these findings support a model in which all primate lentivirus capsids assemble by a conserved pathway of HP68-containing, energy-dependent assembly intermediates that have specific biochemical features...
  47. Nattkemper L, Zhao Z, Nichols A, Papoiu A, Shively C, Chen Z, et al. Overexpression of the gastrin-releasing peptide in cutaneous nerve fibers and its receptor in the spinal cord in primates with chronic itch. J Invest Dermatol. 2013;133:2489-2492 pubmed publisher
  48. Kimura N, Samura E, Suzuki K, Okabayashi S, Shimozawa N, Yasutomi Y. Dynein Dysfunction Reproduces Age-Dependent Retromer Deficiency: Concomitant Disruption of Retrograde Trafficking Is Required for Alteration in ?-Amyloid Precursor Protein Metabolism. Am J Pathol. 2016;186:1952-1966 pubmed publisher
    ..Here, we report that aging itself affects retromer trafficking in cynomolgus monkey brains...
  49. Dhungana S, Carlson J, Pathmasiri W, McRitchie S, Davis M, Sumner S, et al. Impact of a western diet on the ovarian and serum metabolome. Maturitas. 2016;92:134-142 pubmed publisher
    ..A retrospective, observational study was done using archived ovarian tissue and serum from midlife cynomolgus monkeys (Macaca fasicularis)...
  50. Beattie M, Reguyal C, Porcu P, Daunais J, Grant K, Morrow A. Neuroactive Steroid (3?,5?)3-hydroxypregnan-20-one (3?,5?-THP) and Pro-inflammatory Cytokine MCP-1 Levels in Hippocampus CA1 are Correlated with Voluntary Ethanol Consumption in Cynomolgus Monkey. Alcohol Clin Exp Res. 2017;: pubmed publisher
    ..the relationship between 3?,5?-THP levels in the hippocampus and voluntary ethanol consumption in the cynomolgus monkey following daily self-administration of ethanol for 12 months and further examined the relationship to HPA ..
  51. Zhang Y, Sun J, Tan M, Liu Y, Li Q, Jiang H, et al. Species-Specific Involvement of Integrin αIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys. Mol Ther. 2018;26:1457-1470 pubmed publisher
    ..pre-clinical safety evaluation studies, acute thrombocytopenia was observed after administration of CH12 in cynomolgus monkeys, but not rats...
  52. Sch tzl H, Da Costa M, Taylor L, Cohen F, Prusiner S. Prion protein gene variation among primates. J Mol Biol. 1995;245:362-74 pubmed
    ..Alignment of primate and other mammalian PrP sequences suggests that codons between 90 and 130 have a profound influence on the transmissibility of prions from one species to another...
  53. Verga Falzacappa M, Segat L, Puppini B, Amoroso A, Crovella S. Evolution of the mannose-binding lectin gene in primates. Genes Immun. 2004;5:653-61 pubmed
  54. Hallett P, Deleidi M, Astradsson A, Smith G, Cooper O, Osborn T, et al. Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell. 2015;16:269-74 pubmed publisher
    ..Here, we analyzed cynomolgus monkey (CM) iPSC-derived midbrain dopamine neurons for up to 2 years following autologous transplantation in a ..
  55. Zhu F, Liu M, Pan Y, Wang X, Chen Y. [Small hairpin RNA targeting inhibition of NF-κB gene in endometriosis therapy of Macaca fascicularis]. Zhonghua Fu Chan Ke Za Zhi. 2015;50:48-53 pubmed
    ..endometriosis and identify the function of NF-κB on the maintenance and development of endometriosis in Macaca fascicularis. The Macaca fascicularis model of endometriosis was developed, which divided into experimental group, ..
  56. Liu G, Chen M, Mi N, Yang W, Li X, Wang P, et al. Increased oligomerization and phosphorylation of α-synuclein are associated with decreased activity of glucocerebrosidase and protein phosphatase 2A in aging monkey brains. Neurobiol Aging. 2015;36:2649-59 pubmed publisher
    ..Here, we show that oligomeric α-syn levels increase with age in the brain of cynomolgus monkeys and are accompanied by a decrease in the expression and activity of glucocerebrosidase (GCase), a lysosomal ..
  57. Wang J, Wang L, Xiang Y, Ricklin D, Lambris J, Chen G. Using an in vitro xenoantibody-mediated complement-dependent cytotoxicity model to evaluate the complement inhibitory activity of the peptidic C3 inhibitor Cp40. Clin Immunol. 2016;162:37-44 pubmed publisher
    ..Using the same method to compare the effects of Cp40 on complement activation in humans, rhesus and cynomolgus monkeys, we found that the inhibitory patterns were similar overall...
  58. Cui D, Zhou Y. Stress-relevant social behaviors of middle-class male cynomolgus monkeys (Macaca fascicularis). Dongwuxue Yanjiu. 2015;36:337-41 pubmed
    ..as well as among group members holding higher or lower social status, were analyzed in captive male-only cynomolgus monkey groups...
  59. Wei C, Zhang G, Clark T, Barletta F, Tumey L, Rago B, et al. Where Did the Linker-Payload Go? A Quantitative Investigation on the Destination of the Released Linker-Payload from an Antibody-Drug Conjugate with a Maleimide Linker in Plasma. Anal Chem. 2016;88:4979-86 pubmed publisher
    ..Furthermore, the albumin adduct was also identified in 96 h and 168 h postdose in vivo cynomolgus monkey plasma...
  60. Oshima S, Fujii Y, Karrer E, Takamura F, Chapin S, Neighbors M, et al. Immunosuppressive effect of ASP2408, a novel CD86-selective variant of CTLA4-Ig, in rats and cynomolgus monkeys. Int Immunopharmacol. 2016;40:310-317 pubmed publisher
    ..Here we evaluated the effect of ASP2408 in vitro using cynomolgus monkey and rat T cell proliferation assays and in vivo using cynomolgus monkey tetanus toxoid (TTx) immunization ..
  61. Kiessling P, Lledo Garcia R, Watanabe S, Langdon G, Tran D, Bari M, et al. The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study. Sci Transl Med. 2017;9: pubmed publisher
    ..Rozanolixizumab (UCB7665; CA170_01519.g57 IgG4P) is an anti-human FcRn monoclonal antibody. In cynomolgus monkeys, rozanolixizumab reduced IgG (maximum 75 to 90% by about day 10), was well tolerated, and did not increase ..
  62. Pluta R, Butman J, Schatlo B, Johnson D, Oldfield E. Subarachnoid hemorrhage and the distribution of drugs delivered into the cerebrospinal fluid. Laboratory investigation. J Neurosurg. 2009;111:1001-7, 1-4 pubmed publisher
    ..Ten cynomolgus monkeys were assigned to SAH and sham SAH surgery groups (5 in each group)...
  63. Yasukochi Y, Satta Y. Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion. Genome Biol Evol. 2015;7:1053-67 pubmed publisher
  64. Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, et al. Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body. Sci Rep. 2016;6:24868 pubmed publisher
    ..Here, we report for the first time, the generation of green fluorescent protein (GFP) transgenic cynomolgus monkeys by lentivirus infection...
  65. Thind K, Goldsmith P. Expression of estrogen and progesterone receptors in glutamate and GABA neurons of the pubertal female monkey hypothalamus. Neuroendocrinology. 1997;65:314-24 pubmed
    ..To identify those neurons in midpubertal female cynomolgus monkeys, we performed immunofluorescence staining for ER or for PR in separate sets of hypothalamic sections, and ..
  66. Moore K, Zhang Q, Murgolo N, Hosted T, Duffy R. Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants. Comp Biochem Physiol B Biochem Mol Biol. 2009;154:419-26 pubmed publisher
    ..A 1086 base pair sequence cloned from cynomolgus monkey colon cDNA has 85.1% and 83.4% homology with the mouse and rat GPR120 sequences, and 97...
  67. Takeda E, Kono K, Hulme A, Hope T, Nakayama E, Shioda T. Fluorescent image analysis of HIV-1 and HIV-2 uncoating kinetics in the presence of old world monkey TRIM5α. PLoS ONE. 2015;10:e0121199 pubmed publisher
    ..HIV-2 isolate GH123, whose infectivity was suppressed by cynomolgus monkey (CM) TRIM5α, showed accelerated uncoating in the presence of CM TRIM5α...
  68. Mason W. Animal models and the molecular biology of hepadnavirus infection. Cold Spring Harb Perspect Med. 2015;5: pubmed publisher
    ..orangutans, gibbon apes, and, more recently, tree shrews (Tupaia belangeri) and cynomolgus macaques (Macaca fascicularis)...
  69. Bohlen M, Warren S, May P. A central mesencephalic reticular formation projection to the supraoculomotor area in macaque monkeys. Brain Struct Funct. 2016;221:2209-29 pubmed publisher
    ..This study in Macaca fascicularis monkeys investigates the pattern of central mesencephalic reticular formation projections to the area in ..
  70. Kim T, Park H, Cho K, Kim J, Park M, Choi J, et al. Comparison of Methods for Determining ABO Blood Type in Cynomolgus Macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2015;54:255-60 pubmed
    Thorough examination of ABO blood type in cynomolgus monkeys is an essential experimental step to prevent humoral rejection during transplantation research...
  71. Biggs E, Liang L, Naylor J, Madalli S, Collier R, Coghlan M, et al. Development and characterisation of a novel glucagon like peptide-1 receptor antibody. Diabetologia. 2018;61:711-721 pubmed publisher
    ..The monoclonal antibody Glp1R0017 antagonised mouse, human, rat, cynomolgus monkey and dog GLP1R...
  72. Herrero M, Hirsch E, Kastner A, Luquin M, Javoy Agid F, Gonzalo L, et al. Neuromelanin accumulation with age in catecholaminergic neurons from Macaca fascicularis brainstem. Dev Neurosci. 1993;15:37-48 pubmed
    ..upper brainstem and the degree of their melanization from birth to the onset of senescence in 5 monkeys (Macaca fascicularis) aged 0, 1.5, 3.5, 8 and 13 years...
  73. Boyson J, McAdam S, Gallimore A, Golos T, Liu X, Gotch F, et al. The MHC E locus in macaques is polymorphic and is conserved between macaques and humans. Immunogenetics. 1995;41:59-68 pubmed
    ..We isolated four E locus alleles from five rhesus monkeys and two E locus alleles from one cynomolgus monkey, which indicated that the E locus in macaques is polymorphic...
  74. Girard Buttoz C, Heistermann M, Rahmi E, Agil M, Ahmad Fauzan P, Engelhardt A. Androgen correlates of male reproductive effort in wild male long-tailed macaques (Macaca fascicularis): A multi-level test of the challenge hypothesis. Physiol Behav. 2015;141:143-53 pubmed publisher
  75. Abdiche Y, Yeung Y, Chaparro Riggers J, Barman I, Strop P, Chin S, et al. The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity. MAbs. 2015;7:331-43 pubmed publisher
    ..8, and shows less than 25% variation across the other human subtypes. Human IgG1 binds cynomolgus monkey FcRn with a 2-fold higher affinity than human FcRn, and binds both mouse and rat FcRn with a 10-fold higher ..
  76. Osada N, Hettiarachchi N, Adeyemi Babarinde I, Saitou N, Blancher A. Whole-genome sequencing of six Mauritian Cynomolgus macaques (Macaca fascicularis) reveals a genome-wide pattern of polymorphisms under extreme population bottleneck. Genome Biol Evol. 2015;7:821-30 pubmed publisher
    Cynomolgus macaques (Macaca fascicularis) were introduced to the island of Mauritius by humans around the 16th century...
  77. Kang Y, Zheng B, Shen B, Chen Y, Wang L, Wang J, et al. CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH. Hum Mol Genet. 2015;24:7255-64 pubmed publisher
    ..short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)-mediated genome targeting in cynomolgus monkeys. Here, we describe a male fetal monkey in which targeted genome editing using CRISPR/Cas9 produced Dax1-null ..
  78. Maldjian J, Shively C, Nader M, Friedman D, Whitlow C. Multi-Atlas Library for Eliminating Normalization Failures in Non-Human Primates. Neuroinformatics. 2016;14:183-90 pubmed publisher
    ..A library of study-specific templates (SST) spanning three Old World primate species (Macaca fascicularis, M. mulatta, Chlorocebus aethiops) was created using a previously described unbiased automated approach...
  79. Russo G. Comparative sacral morphology and the reconstructed tail lengths of five extinct primates: Proconsul heseloni, Epipliopithecus vindobonensis, Archaeolemur edwardsi, Megaladapis grandidieri, and Palaeopropithecus kelyus. J Hum Evol. 2016;90:135-62 pubmed publisher
    ..g., Macaca nemestrina) and longer-tailed (e.g., Macaca fascicularis) primates, respectively...
  80. Hu X, Xu Y, Zhong Z, Wu Y, Zhao J, Wang Y, et al. A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Nonhuman Primates: Paracrine Activity Without Remuscularization. Circ Res. 2016;118:970-83 pubmed publisher
    ..5% oxygen (HP-MSCs) for 24 hours and then tested in the infarcted hearts of Cynomolgus monkeys (1×10(7) cells per heart)...
  81. Zhang X, Kadir K, Quintanilla Zariñan L, Villano J, Houghton P, Du H, et al. Distribution and prevalence of malaria parasites among long-tailed macaques (Macaca fascicularis) in regional populations across Southeast Asia. Malar J. 2016;15:450 pubmed publisher
    ..One of their major natural hosts, the long-tailed macaque (Macaca fascicularis), is host to two other species of Plasmodium (Plasmodium fieldi and Plasmodium coatneyi) and is widely ..
  82. Pan X, Zeng X, Hong J, Yuan C, Cui L, Ma J, et al. Effects of Ketamine on Metabolomics of Serum and Urine in Cynomolgus Macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2016;55:558-64 pubmed
    ..Our study suggests that these influences should be considered in the design of experiments and the interpretation related blood and urine data from ketamine-sedated cynomolgus macaques. ..
  83. Rybak E, Shipley S, Tatarov I, Zhang T, Sun W, Braileanu G, et al. Clinical Trypanosoma cruzi Disease after Cardiac Transplantation in a Cynomolgus Macaque (Macaca fascicularis). Comp Med. 2016;66:494-498 pubmed
    ..The final diagnosis was clinical anemia due to T. cruzi infection. This study represents the first reported case of Chagas disease after heart transplant in a NHP. ..
  84. Qiao X, Liu Y, Luo L, Chen L, Zhao C, Ai X. Effects of naturally occurring charged mutations on the structure, stability, and binding of the Pin1 WW domain. Biochem Biophys Res Commun. 2017;487:470-476 pubmed publisher
    ..In the present work, two naturally occurring Pin1 WW variants, namely, G20D and S16R, derived from the cynomolgus monkey and African green monkey, respectively, were selected to investigate the influence of charge mutation on the ..
  85. Ram Y, Ross C. Evaluating the triplet hypothesis during rhythmic mastication in primates. J Exp Biol. 2018;221: pubmed publisher
    ..Instead, the primate masticatory motor pattern is malleable within individual cycles, within individual animals and therefore within species. ..
  86. Esquejo R, Salatto C, Delmore J, Albuquerque B, Reyes A, Shi Y, et al. Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models. EBioMedicine. 2018;31:122-132 pubmed publisher
    ..These effects require AMPK activity in the hepatocytes. Treatment of hyperlipidemic rats or cynomolgus monkeys with PF-06409577 for 6weeks resulted in a reduction in circulating cholesterol...
  87. Travis G, Sutcliffe J. Phenol emulsion-enhanced DNA-driven subtractive cDNA cloning: isolation of low-abundance monkey cortex-specific mRNAs. Proc Natl Acad Sci U S A. 1988;85:1696-700 pubmed
    ..Two of the lower-abundance mRNAs were expressed at levels reduced by a factor of 10 in Alzheimer disease relative to normal human cortex. One of these was identified as the monkey preprosomatostatin I mRNA. ..
  88. Sharif N, Li L, Katoli P, Xu S, Veltman J, Li B, et al. Preclinical pharmacology, ocular tolerability and ocular hypotensive efficacy of a novel non-peptide bradykinin mimetic small molecule. Exp Eye Res. 2014;128:170-80 pubmed publisher
    ..However, FR-190997 efficaciously lowered IOP of conscious ocular hypertensive cynomolgus monkey eyes (e.g., 34.5 ± 7.5% decrease; 6 h post-dose of 30 μg t.o.; n = 8)...
  89. Kirchgessner T, Martin R, Sleph P, Grimm D, Liu X, Lupisella J, et al. Pharmacological characterization of a novel liver X receptor agonist with partial LXRα activity and a favorable window in nonhuman primates. J Pharmacol Exp Ther. 2015;352:305-14 pubmed publisher
    ..a partial LXRβ selective agonist, has decreased lipogenic potential compared with a full pan agonist in cynomolgus monkeys, with similar potency in the induction of genes known to stimulate RCT...
  90. Gamberini M, Bakola S, Passarelli L, Burman K, Rosa M, Fattori P, et al. Thalamic projections to visual and visuomotor areas (V6 and V6A) in the Rostral Bank of the parieto-occipital sulcus of the Macaque. Brain Struct Funct. 2016;221:1573-89 pubmed publisher
    ..two of these areas (V6 and V6A), based on 14 retrograde neuronal tracer injections in 11 hemispheres of 9 Macaca fascicularis. The injections were placed either by direct visualisation or using electrophysiological guidance, and the ..
  91. Shorey Kendrick L, Ford M, Allen D, Kuryatov A, Lindstrom J, Wilhelm L, et al. Nicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans. Neuropharmacology. 2015;96:263-73 pubmed publisher
    ..Most significantly, cynomolgus monkeys express a similar α5 nAChR Asp398Asn polymorphism to the human α5 Asp398Asn polymorphism that has been ..
  92. Carlson A, Kelly R, Fetterer D, Rico P, Bailey E. Pharmacokinetics of 2 Formulations of Transdermal Fentanyl in Cynomolgus Macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2016;55:436-42 pubmed
    ..patch (25 ?g/h), were determined when applied topically to the dorsal scapular area of cynomolgus macaques (Macaca fascicularis). Serum fentanyl concentrations were analyzed by using liquid chromatography-mass spectrometry...