equine

Summary

Alias: horse, domestic horse, Equus caballus, Equus ferus caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, Equus caballus Linnaeus, 1758

Top Publications

  1. Oslund K, Adamson G, Wu R. Evaluation of MUC5AC expression and upregulation in airway epithelial cells of horses. Am J Vet Res. 2010;71:690-6 pubmed publisher
    To isolate and culture primary equine airway epithelial cells in vitro and elucidate the major cytokines involved in expression of the gel-forming mucin gene MUC5AC in horses.
  2. McDonald R, Fleming R, Beeley J, Bovell D, Lu J, Zhao X, et al. Latherin: a surfactant protein of horse sweat and saliva. PLoS ONE. 2009;4:e5726 pubmed publisher
    ..latherin, determined from cDNA analysis, is highly conserved across four geographically dispersed equid species (horse, zebra, onager, ass), and is similar to a family of proteins only found previously in the oral cavity and ..
  3. Wade C, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, et al. Genome sequence, comparative analysis, and population genetics of the domestic horse. Science. 2009;326:865-7 pubmed publisher
    We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication...
  4. Raudsepp T, McCue M, Das P, Dobson L, Vishnoi M, Fritz K, et al. Genome-wide association study implicates testis-sperm specific FKBP6 as a susceptibility locus for impaired acrosome reaction in stallions. PLoS Genet. 2012;8:e1003139 pubmed publisher
    ..Here we conducted Equine SNP50 Beadchip genotyping and GWAS using 7 IAR-affected and 37 control Thoroughbred stallions...
  5. Kennedy M. Latherin and other biocompatible surfactant proteins. Biochem Soc Trans. 2011;39:1017-22 pubmed publisher
    ..It may consequently have a dual role in horse sweat in both evaporative cooling and controlling microbial growth in the pelt that would otherwise be resourced ..
  6. Giesecke K, Hamann H, Sieme H, Distl O. Evaluation of prolactin receptor (PRLR) as candidate gene for male fertility in Hanoverian warmblood horses. Reprod Domest Anim. 2010;45:e124-30 pubmed publisher
    ..Screening the equine PRLR gene for polymorphisms in Hanoverian stallions revealed two single nucleotide polymorphisms (SNPs)...
  7. Bellone R, Forsyth G, Leeb T, Archer S, Sigurdsson S, Imsland F, et al. Fine-mapping and mutation analysis of TRPM1: a candidate gene for leopard complex (LP) spotting and congenital stationary night blindness in horses. Brief Funct Genomics. 2010;9:193-207 pubmed publisher
    ..Further, this work has identified several potential regulatory elements of the TRPM1 gene that should be investigated further in this and other species. ..
  8. Ishikawa Y, Vranka J, Boudko S, Pokidysheva E, Mizuno K, Zientek K, et al. Mutation in cyclophilin B that causes hyperelastosis cutis in American Quarter Horse does not affect peptidylprolyl cis-trans isomerase activity but shows altered cyclophilin B-protein interactions and affects collagen folding. J Biol Chem. 2012;287:22253-65 pubmed publisher
    ..B found in the American Quarter Horse leads to autosomal recessive hyperelastosis cutis, also known as hereditary equine regional dermal asthenia...
  9. Dart A, Dart C, Dudhia J, Perkins N, Canfield P, Smith R. A preliminary study on the effect of wounding on transforming growth factor-?1 and cartilage oligomeric matrix protein concentrations in the skin of horses. Vet Surg. 2011;40:59-65 pubmed publisher
    ..To evaluate whether wound type or site influence the production of cartilage oligomeric matrix protein (COMP) and transforming growth factor ?1 (TGF-?1), and determine if there is a correlation between TGF-?1and COMP during healing...

More Information

Publications72

  1. Carter R, Engiles J, Megee S, Senoo M, Galantino Homer H. Decreased expression of p63, a regulator of epidermal stem cells, in the chronic laminitic equine hoof. Equine Vet J. 2011;43:543-51 pubmed publisher
    Abnormal epidermal stem cell regulation may contribute to the pathogenesis of equine chronic laminitis.
  2. Knych H, McKemie D, Stanley S. Molecular cloning, expression, and initial characterization of members of the CYP3A family in horses. Drug Metab Dispos. 2010;38:1820-7 pubmed publisher
    The use of performance-enhancing drugs in the horse racing industry combined with the need for more rational approaches in the use of therapeutic agents in equids necessitates additional studies on the spectrum, content, and catalytic ..
  3. Astakhova N, Perelygin A, Zharkikh A, Lear T, Coleman S, MacLeod J, et al. Characterization of equine and other vertebrate TLR3, TLR7, and TLR8 genes. Immunogenetics. 2009;61:529-39 pubmed publisher
    Toll-like receptors 3, 7, and 8 (TLR3, TLR7, and TLR8) were studied in the genomes of the domestic horse and several other mammals. The messenger RNA sequences and exon/intron structures of these TLR genes were determined...
  4. Cappelli K, Felicetti M, Capomaccio S, Pieramati C, Silvestrelli M, Verini Supplizi A. Exercise-induced up-regulation of MMP-1 and IL-8 genes in endurance horses. BMC Physiol. 2009;9:12 pubmed publisher
    The stress response is a critical factor in the training of equine athletes; it is important for performance and for protection of the animal against physio-pathological disorders...
  5. DiMaio Knych H, DeStefano Shields C, Buckpitt A, Stanley S. Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization. Arch Biochem Biophys. 2009;485:49-55 pubmed publisher
    ..Accordingly, a cytochrome P450 monooxygenase in the 2C family was cloned from an equine liver, sequenced and expressed in a baculovirus expression system...
  6. Andersson L, Axelsson J, Dubielzig R, Lindgren G, Ekesten B. Multiple congenital ocular anomalies in Icelandic horses. BMC Vet Res. 2011;7:21 pubmed publisher
    ..ocular defects are caused by a recent mutation that is restricted to horses that are related to the Rocky Mountain Horse breed...
  7. Sandmeyer L, Bellone R, Archer S, Bauer B, Nelson J, Forsyth G, et al. Congenital stationary night blindness is associated with the leopard complex in the Miniature Horse. Vet Ophthalmol. 2012;15:18-22 pubmed publisher
    To determine if congenital stationary night blindness (CSNB) exists in the Miniature Horse in association with leopard complex spotting patterns (LP), and to investigate if CSNB in the Miniature Horse is associated with three single ..
  8. Bellone R, Brooks S, Sandmeyer L, Murphy B, Forsyth G, Archer S, et al. Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus). Genetics. 2008;179:1861-70 pubmed publisher
    ..Decreased expression of TRPM1 in the eye and the skin may alter bipolar cell signaling as well as melanocyte function, thus causing both CSNB and LP in horses. ..
  9. Rosengren Pielberg G, Golovko A, Sundström E, Curik I, Lennartsson J, Seltenhammer M, et al. A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nat Genet. 2008;40:1004-9 pubmed publisher
    ..The Gray horse provides a notable example of how humans have cherry-picked mutations with favorable phenotypic effects in ..
  10. Giesecke K, Hamann H, Stock K, Woehlke A, Sieme H, Distl O. Evaluation of SPATA1-associated markers for stallion fertility. Anim Genet. 2009;40:359-65 pubmed publisher
    ..fertility is an economically important trait because the use of artificial insemination is increasing in the horse industry and superior sires are used more intensely...
  11. Haase B, Brooks S, Schlumbaum A, Azor P, Bailey E, Alaeddine F, et al. Allelic heterogeneity at the equine KIT locus in dominant white (W) horses. PLoS Genet. 2007;3:e195 pubmed
    ..We determined the sequence and genomic organization of the approximately 82 kb equine KIT gene...
  12. Yoon M, Berger T, Roser J. Localization of insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR) in equine testes. Reprod Domest Anim. 2011;46:221-8 pubmed publisher
    ..Immunolabelling of IGF-I and IGF-IR was not observed in Sertoli cells. In conclusion, IGF-I is localized in equine spermatogenic and Leydig cells, and IGF-IR is present in spermatogonia, spermatocytes and Leydig cells, suggesting ..
  13. Tozaki T, Miyake T, Kakoi H, Gawahara H, Sugita S, Hasegawa T, et al. A genome-wide association study for racing performances in Thoroughbreds clarifies a candidate region near the MSTN gene. Anim Genet. 2010;41 Suppl 2:28-35 pubmed publisher
    ..These findings suggest the presence of a gene affecting the racing performance in Thoroughbred racehorses in this region on ECA18. ..
  14. Smith M, Wright I, Minshall G, Dudhia J, Verheyen K, Heinegard D, et al. Increased cartilage oligomeric matrix protein concentrations in equine digital flexor tendon sheath synovial fluid predicts intrathecal tendon damage. Vet Surg. 2011;40:54-8 pubmed publisher
    ..To evaluate digital flexor tendon sheath (DFTS) synovial fluid cartilage oligomeric matrix protein (COMP) concentrations as a molecular marker for intrathecal pathology...
  15. Bedford Guaus S, McPartlin L, Xie J, Westmiller S, Buffone M, Roberson M. Molecular cloning and characterization of phospholipase C zeta in equine sperm and testis reveals species-specific differences in expression of catalytically active protein. Biol Reprod. 2011;85:78-88 pubmed publisher
    ..of this research were to clone and characterize the intracellular Ca(2+)-releasing activity and expression of equine PLCZ in sperm and testis...
  16. Martino N, Lange Consiglio A, Cremonesi F, Valentini L, Caira M, Guaricci A, et al. Functional expression of the extracellular calcium sensing receptor (CaSR) in equine umbilical cord matrix size-sieved stem cells. PLoS ONE. 2011;6:e17714 pubmed publisher
    ..and the calcimimetic NPS R-467, a known calcium-sensing receptor (CaSR) agonist, on growth/proliferation of two equine size-sieved umbilical cord matrix mesenchymal stem cell (eUCM-MSC) lines...
  17. Jung H, Song H, Yoon M. Stage-dependent DAZL localization in stallion germ cells. Anim Reprod Sci. 2014;147:32-8 pubmed publisher
    ..We conclude that DAZL can be used as a marker of pre-meiotic germ cells in stallions. ..
  18. Brooks S, Gabreski N, Miller D, Brisbin A, Brown H, Streeter C, et al. Whole-genome SNP association in the horse: identification of a deletion in myosin Va responsible for Lavender Foal Syndrome. PLoS Genet. 2010;6:e1000909 pubmed publisher
    ..LFS has been primarily diagnosed in a subgroup of the Arabian breed, the Egyptian Arabian horse. The condition is characterized by multiple neurological abnormalities and a dilute coat color...
  19. McGivney B, Browne J, Fonseca R, Katz L, MacHugh D, Whiston R, et al. MSTN genotypes in Thoroughbred horses influence skeletal muscle gene expression and racetrack performance. Anim Genet. 2012;43:810-2 pubmed publisher
    ..A MSTN SNP significantly associated with Thoroughbred horse racing phenotypes has recently been identified as well as significant reductions in Thoroughbred skeletal muscle ..
  20. Bujacz A. Structures of bovine, equine and leporine serum albumin. Acta Crystallogr D Biol Crystallogr. 2012;68:1278-89 pubmed publisher
    ..Here, the crystal structures of serum albumins isolated from bovine, equine and leporine blood plasma are reported. The structure of bovine serum albumin (BSA) was determined at 2...
  21. Morrison P, Bing C, Harris P, Maltin C, Grove White D, Argo C. Post-mortem stability of RNA in skeletal muscle and adipose tissue and the tissue-specific expression of myostatin, perilipin and associated factors in the horse. PLoS ONE. 2014;9:e100810 pubmed publisher
    Obesity, a major concern for equine welfare, is highly prevalent in the leisure horse population. Skeletal-muscle and adipose tissues are important determinants of maintenance energy requirements...
  22. Brooks S, Lear T, Adelson D, Bailey E. A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses. Cytogenet Genome Res. 2007;119:225-30 pubmed publisher
    ..Here, we report TO associated with a large paracentric chromosome inversion on horse chromosome 3...
  23. DiMaio Knych H, Stanley S. Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. Biochem Pharmacol. 2008;76:904-11 pubmed publisher
    ..In the horse, the presence of a member of the CYP2D family has been suggested from studies with equine liver microsomes, however its presence has not been definitively proven...
  24. Giesecke K, Hamann H, Sieme H, Distl O. INHBA-associated markers as candidates for stallion fertility. Reprod Domest Anim. 2010;45:342-7 pubmed publisher
    ..This is the first report on INHBA as an associated candidate gene with the LSM of stallions and the paternal and embryonic component of BVs for the pregnancy rate per oestrus. ..
  25. Bellone R, Holl H, Setaluri V, Devi S, Maddodi N, Archer S, et al. Evidence for a retroviral insertion in TRPM1 as the cause of congenital stationary night blindness and leopard complex spotting in the horse. PLoS ONE. 2013;8:e78280 pubmed publisher
    ..against the identification of this insertion in three ancient DNA samples suggests it has been maintained in the horse gene pool for at least 17,000 years...
  26. Hauswirth R, Haase B, Blatter M, Brooks S, Burger D, Drogemuller C, et al. Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses. PLoS Genet. 2012;8:e1002653 pubmed publisher
    ..Some, but not all, splashed white horses are deaf. We analyzed a Quarter Horse family segregating for the splashed white coat color...
  27. Salazar Ortiz J, Camous S, Briant C, Lardic L, Chesneau D, Guillaume D. Effects of nutritional cues on the duration of the winter anovulatory phase and on associated hormone levels in adult female Welsh pony horses (Equus caballus). Reprod Biol Endocrinol. 2011;9:130 pubmed publisher
    ..The annual rhythm driven by melatonin secretion is only responsible for the timing of the breeding season. The occurrence and length of winter ovarian inactivity is defined by metabolic hormones. ..
  28. Sundström E, Komisarczuk A, Jiang L, Golovko A, Navratilova P, Rinkwitz S, et al. Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horses. Pigment Cell Melanoma Res. 2012;25:28-36 pubmed publisher
    ..These results provide strong support for the causative nature of the duplication and constitute an explanation for the melanocyte-specific effects of the Grey allele. ..
  29. Hwang I, Jung E, Yang H, Choi K, Jeung E. Tissue-specific expression of the calcium transporter genes TRPV5, TRPV6, NCX1, and PMCA1b in the duodenum, kidney and heart of Equus caballus. J Vet Med Sci. 2011;73:1437-44 pubmed
    ..mRNA and protein expression of these calcium transporter genes in the duodenum, kidney and heart of the horse (Equus caballus) was examined using reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis...
  30. Schmitz A, Demmel S, Peters L, Leeb T, Mevissen M, Haase B. Comparative human-horse sequence analysis of the CYP3A subfamily gene cluster. Anim Genet. 2010;41 Suppl 2:72-9 pubmed publisher
    ..We report here the genomic organization of the equine CYP3A gene cluster as well as a comparative analysis with the human CYP3A gene cluster...
  31. Hill E, McGivney B, Gu J, Whiston R, MacHugh D. A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses. BMC Genomics. 2010;11:552 pubmed publisher
    ..Nonetheless, this study demonstrates that the g.66493737C>T SNP provides the most powerful genetic marker for prediction of race distance aptitude in Thoroughbreds. ..
  32. Andersson L, Juras R, Ramsey D, Eason Butler J, Ewart S, Cothran G, et al. Equine Multiple Congenital Ocular Anomalies maps to a 4.9 megabase interval on horse chromosome 6. BMC Genet. 2008;9:88 pubmed publisher
    b>Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome consists of a diverse set of abnormalities predominantly localized to the frontal part of the eye...
  33. Peters L, Demmel S, Pusch G, Buters J, Thormann W, Zielinski J, et al. Equine cytochrome P450 2B6--genomic identification, expression and functional characterization with ketamine. Toxicol Appl Pharmacol. 2013;266:101-8 pubmed publisher
    ..CYPs have been thoroughly examined in humans and laboratory animals, but little is known about equine CYPs. The characterization of equine CYPs is essential for a better understanding of drug metabolism in horses...
  34. Fox Clipsham L, Carter S, Goodhead I, Hall N, Knottenbelt D, May P, et al. Identification of a mutation associated with fatal Foal Immunodeficiency Syndrome in the Fell and Dales pony. PLoS Genet. 2011;7:e1002133 pubmed publisher
    ..Having identified the associated gene, we are now able to eradicate FIS from equine populations by informed selective breeding.
  35. Nishihara Y, Kato S, Hayashi S. Protein collective motions coupled to ligand migration in myoglobin. Biophys J. 2010;98:1649-57 pubmed publisher
  36. Rios J, Perelygin A, Long M, Lear T, Zharkikh A, Brinton M, et al. Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes. BMC Genomics. 2007;8:313 pubmed publisher
    ..No polymorphisms have yet been identified in either the equine OAS1 or RNASEL genes for use in similar case-control studies. ..
  37. Ho J, Holowachuk E, Norton E, Twigg P, Carter D. X-ray and primary structure of horse serum albumin (Equus caballus) at 0.27-nm resolution. Eur J Biochem. 1993;215:205-12 pubmed
    The amino-acid sequence and three-dimensional structure of equine serum albumin have been determined. The amino-acid sequence was deduced from cDNA isolated from equine liver...
  38. Nergadze S, Magnani E, Attolini C, Bertoni L, Adelson D, Cappelli K, et al. Assignment of the Equus caballus interleukin 8 gene (IL8) to chromosome 3q14.2-->q14.3 by in situ hybridization. Cytogenet Genome Res. 2006;112:341B pubmed publisher
  39. Perelygin A, Zharkikh A, Scherbik S, Brinton M. The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla. J Mol Evol. 2006;63:562-76 pubmed
    ..pig, and dog OAS genes were amplified, sequenced and compared with each other and with those in the human, mouse, horse, and chicken genomes...
  40. Rudolph J, Spier S, Byrns G, Hoffman E. Linkage of hyperkalaemic periodic paralysis in quarter horses to the horse adult skeletal muscle sodium channel gene. Anim Genet. 1992;23:241-50 pubmed
    ..A large Quarter horse pedigree segregating dominant HYPP was studied to determine if mutations of the sodium channel gene are similarly ..
  41. Xu X, Arnason U. The complete mitochondrial DNA sequence of the horse, Equus caballus: extensive heteroplasmy of the control region. Gene. 1994;148:357-62 pubmed
    The sequence of the mitochondrial (mt) DNA of the horse (Equus caballus) was determined. The length of the sequence presented is 16,660 bp...
  42. MacLeod J, Burton Wurster N, Gu D, Lust G. Fibronectin mRNA splice variant in articular cartilage lacks bases encoding the V, III-15, and I-10 protein segments. J Biol Chem. 1996;271:18954-60 pubmed
    ..This new splice variant, which we designate (V+C)-, represents the majority of fibronectin transcripts in equine, canine, and rabbit articular cartilage but is absent in the liver...
  43. Cappelli K, Verini Supplizi A, Capomaccio S, Silvestrelli M. Analysis of peripheral blood mononuclear cells gene expression in endurance horses by cDNA-AFLP technique. Res Vet Sci. 2007;82:335-43 pubmed
    ..The mRNAs sequences obtained were included in the GenBank database as Equus caballus interleukin 8 (IL8), E. caballus retinoblastoma binding protein 6 mRNA (RBBP6), E...
  44. Perelygin A, Lear T, Zharkikh A, Brinton M. Comparative analysis of vertebrate EIF2AK2 (PKR) genes and assignment of the equine gene to ECA15q24-q25 and the bovine gene to BTA11q12-q15. Genet Sel Evol. 2006;38:551-63 pubmed
    The structures of the canine, rabbit, bovine and equine EIF2AK2 genes were determined. Each of these genes has a 5' non-coding exon as well as 15 coding exons...
  45. Goubran Botros H, Poncet P, Rabillon J, Fontaine T, Laval J, David B. Biochemical characterization and surfactant properties of horse allergens. Eur J Biochem. 2001;268:3126-36 pubmed
    A new allergen from horse dander, Equ c 5 has been purified. Its biochemical and biophysical properties have been characterized and compared with those of Equ c 1, Equ c 2 and Equ c 4...
  46. Tryon R, White S, Bannasch D. Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse. Genomics. 2007;90:93-102 pubmed
    Hereditary equine regional dermal asthenia (HERDA), a degenerative skin disease that affects the Quarter Horse breed, was localized to ECA1 by homozygosity mapping...
  47. Yang G, Croaker D, Zhang A, Manglick P, Cartmill T, Cass D. A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndrome (LWFS); a horse variant of Hirschsprung disease. Hum Mol Genet. 1998;7:1047-52 pubmed
    ..First, we identified a full-length cDNA for horse EDNRB . This cDNA fragment contained a 1329 bp open reading frame which encoded 443 amino acid residues...
  48. Caetano A, Pomp D, Murray J, Bowling A. Comparative mapping of 18 equine type I genes assigned by somatic cell hybrid analysis. Mamm Genome. 1999;10:271-6 pubmed
    ..from consensus sequences highly conserved in mammalian species were used to amplify markers for synteny mapping 18 equine type I genes. These markers were used to screen a horse-mouse somatic cell hybrid panel (UCDavis SCH)...
  49. Shin E, Perryman L, Meek K. A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation. J Immunol. 1997;158:3565-9 pubmed
    The equine SCID defect is more severe than its murine counterpart in that SCID foals are incapable of forming either coding or signal joints, whereas SCID mice manifest normal signal joint formation...
  50. Albright D, Bailey E, Woodward J. Nucleotide sequence of a cDNA clone of the horse (Equus caballus) DRA gene. Immunogenetics. 1991;34:136-8 pubmed
  51. D Innocenzo B, Salzano A, D Ambrosio C, Gazzano A, Niccolini A, Sorce C, et al. Secretory proteins as potential semiochemical carriers in the horse. Biochemistry. 2006;45:13418-28 pubmed
    Two soluble proteins were isolated as major secretory products of horse sweat and of the parotid gland and characterized for structural and functional properties...
  52. Gregoire C, Rosinski Chupin I, Rabillon J, Alzari P, David B, Dandeu J. cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamily. J Biol Chem. 1996;271:32951-9 pubmed
    The gene encoding the major horse allergen, designated Equus caballus allergen 1 (Equ c1), was cloned from total cDNA of sublingual salivary glands by reverse transcription-polymerase chain reaction using synthetic degenerate ..
  53. Marklund L, Moller M, Sandberg K, Andersson L. A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated with the chestnut coat color in horses. Mamm Genome. 1996;7:895-9 pubmed
    ..The polymorphism can be detected with a simple PCR-RFLP test, since the mutation creates a TaqI restriction site in the chestnut allele. ..
  54. Tallmadge R, Lear T, Antczak D. Genomic characterization of MHC class I genes of the horse. Immunogenetics. 2005;57:763-74 pubmed
    The availability of a contig of bacterial artificial chromosome (BAC) clones spanning the equine major histocompatibility complex (MHC) made possible a detailed analysis of horse MHC class I genes...
  55. Marklund S, Moller M, Sandberg K, Andersson L. Close association between sequence polymorphism in the KIT gene and the roan coat color in horses. Mamm Genome. 1999;10:283-8 pubmed
    ..Rn has previously been mapped to equine linkage group (LG) II...
  56. Lascombe M, Gregoire C, Poncet P, Tavares G, Rosinski Chupin I, Rabillon J, et al. Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes. J Biol Chem. 2000;275:21572-7 pubmed
    The three-dimensional structure of the major horse allergen Equ c 1 has been determined at 2.3 A resolution by x-ray crystallography. Equ c 1 displays the typical fold of lipocalins, a beta-barrel flanked by a C-terminal alpha-helix...
  57. Gordon M, McKeever K, Betros C, Manso Filho H. Plasma leptin, ghrelin and adiponectin concentrations in young fit racehorses versus mature unfit standardbreds. Vet J. 2007;173:91-100 pubmed
  58. Brunberg E, Andersson L, Cothran G, Sandberg K, Mikko S, Lindgren G. A missense mutation in PMEL17 is associated with the Silver coat color in the horse. BMC Genet. 2006;7:46 pubmed
    The Silver coat color, also called Silver dapple, in the horse is characterized by dilution of the black pigment in the hair. This phenotype shows an autosomal dominant inheritance...
  59. Santschi E, Purdy A, Valberg S, Vrotsos P, Kaese H, Mickelson J. Endothelin receptor B polymorphism associated with lethal white foal syndrome in horses. Mamm Genome. 1998;9:306-9 pubmed
    ..In this report we identify a polymorphism in the equine EDNRB gene closely associated with OLWS...
  60. van den Hoven R, Duvigneau J, Hartl R, Gemeiner M. Clenbuterol affects the expression of messenger RNA for interleukin 10 in peripheral leukocytes from horses challenged intrabronchially with lipopolysaccharides. Vet Res Commun. 2006;30:921-8 pubmed
    ..Thus the results of this study indicated that clenbuterol can modulate the expression of IL-10 mRNA in peripheral white blood cells in those horses with small airway diseases that have been exposed to LPS. ..
  61. Rieder S, Taourit S, Mariat D, Langlois B, Guerin G. Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus). Mamm Genome. 2001;12:450-5 pubmed
    ..Our panel represented 22 different horse breeds, including 11 different coat colors of Equus caballus. The comparison of a 1721-bp genomic fragment of MC1R among the 11 coat color phenotypes revealed no sequence ..
  62. Brooks S, Bailey E. Exon skipping in the KIT gene causes a Sabino spotting pattern in horses. Mamm Genome. 2005;16:893-902 pubmed
    Sabino (SB) is a white spotting pattern in the horse characterized by white patches on the face, lower legs, or belly, and interspersed white hairs on the midsection...
  63. Perelygin A, Lear T, Zharkikh A, Brinton M. Structure of equine 2'-5'oligoadenylate synthetase (OAS) gene family and FISH mapping of OAS genes to ECA8p15-->p14 and BTA17q24-->q25. Cytogenet Genome Res. 2005;111:51-6 pubmed
    ..In this study, the structures of four equine OAS genes were determined using DNA sequences derived from fifteen cDNA and four BAC clones...