Alias: horse, domestic horse, Equus caballus, Equus ferus caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, Equus caballus Linnaeus, 1758
Publications228 found, 100 shown here
- Evaluation of MUC5AC expression and upregulation in airway epithelial cells of horsesKaren L Oslund
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine and Center for Comparative Respiratory Biology and Medicine, School of Medicine, University of California Davis, Davis, CA 95616, USA
Am J Vet Res 71:690-6. 2010To isolate and culture primary equine airway epithelial cells in vitro and elucidate the major cytokines involved in expression of the gel-forming mucin gene MUC5AC in horses.
- cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamilyC Gregoire
Unite d Immuno Allergie, Departement de Physiopathologie, Institut Pasteur, 28 rue du Dr Roux, 75024 Paris Cedex 15, France
J Biol Chem 271:32951-9. 1996The gene encoding the major horse allergen, designated Equus caballus allergen 1 (Equ c1), was cloned from total cDNA of sublingual salivary glands by reverse transcription-polymerase chain reaction using synthetic degenerate ..
- Effects of nutritional cues on the duration of the winter anovulatory phase and on associated hormone levels in adult female Welsh pony horses (Equus caballus)Juan Salazar-Ortiz
INRA, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
Reprod Biol Endocrinol 9:130. 2011..Mares have an annual reproductive rhythm, with a phase of inactivity in midwinter. The aim of this study was to determine the impact of food restriction on physiological and metabolic hallmarks of this rhythm...
- Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter HorseRobert C Tryon
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 9516, USA
Genomics 90:93-102. 2007Hereditary equine regional dermal asthenia (HERDA), a degenerative skin disease that affects the Quarter Horse breed, was localized to ECA1 by homozygosity mapping...
- Linkage of hyperkalaemic periodic paralysis in quarter horses to the horse adult skeletal muscle sodium channel geneJ A Rudolph
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261
Anim Genet 23:241-50. 1992..A large Quarter horse pedigree segregating dominant HYPP was studied to determine if mutations of the sodium channel gene are similarly ..
- The complete mitochondrial DNA sequence of the horse, Equus caballus: extensive heteroplasmy of the control regionX Xu
Division of Evolutionary Molecular Systematics, Lund, Sweden
Gene 148:357-62. 1994The sequence of the mitochondrial (mt) DNA of the horse (Equus caballus) was determined. The length of the sequence presented is 16,660 bp...
- Fibronectin mRNA splice variant in articular cartilage lacks bases encoding the V, III-15, and I-10 protein segmentsJ N MacLeod
Department of Physiology, James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Biol Chem 271:18954-60. 1996..This new splice variant, which we designate (V+C)-, represents the majority of fibronectin transcripts in equine, canine, and rabbit articular cartilage but is absent in the liver...
- A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated with the chestnut coat color in horsesL Marklund
Department of Animal Breeding and Genetics, Swedish University of Agricultural Science, Uppsala, Sweden
Mamm Genome 7:895-9. 1996..The polymorphism can be detected with a simple PCR-RFLP test, since the mutation creates a TaqI restriction site in the chestnut allele...
- Endothelin receptor B polymorphism associated with lethal white foal syndrome in horsesE M Santschi
Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
Mamm Genome 9:306-9. 1998..In this report we identify a polymorphism in the equine EDNRB gene closely associated with OLWS...
- A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndrome (LWFS); a horse variant of Hirschsprung diseaseG C Yang
Department of Surgical Research, Royal Alexandra Hospital for Children, Westmead, NSW 2145, Australia
Hum Mol Genet 7:1047-52. 1998..First, we identified a full-length cDNA for horse EDNRB . This cDNA fragment contained a 1329 bp open reading frame which encoded 443 amino acid residues...
- Close association between sequence polymorphism in the KIT gene and the roan coat color in horsesS Marklund
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, S 751 24 Uppsala, Sweden
Mamm Genome 10:283-8. 1999..Rn has previously been mapped to equine linkage group (LG) II...
- Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopesM B Lascombe
Unité de Biochimie Structurale CNRS URA 2185, Unite d Immuno Allergie, 25 et 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
J Biol Chem 275:21572-7. 2000The three-dimensional structure of the major horse allergen Equ c 1 has been determined at 2.3 A resolution by x-ray crystallography. Equ c 1 displays the typical fold of lipocalins, a beta-barrel flanked by a C-terminal alpha-helix...
- Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus)S Rieder
Laboratoire de Génétique Biochimique et de Cytogénétique, Département de Génétique Animale, INRA Centre de Recherche de Jouy, 78352 Jouy en Josas Cedex, France
Mamm Genome 12:450-5. 2001..Our panel represented 22 different horse breeds, including 11 different coat colors of Equus caballus. The comparison of a 1721-bp genomic fragment of MC1R among the 11 coat color phenotypes revealed no sequence ..
- Exon skipping in the KIT gene causes a Sabino spotting pattern in horsesSamantha A Brooks
Department of Veterinary Science, 108 Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky 40546 0099, USA
Mamm Genome 16:893-902. 2005Sabino (SB) is a white spotting pattern in the horse characterized by white patches on the face, lower legs, or belly, and interspersed white hairs on the midsection...
- Plasma leptin, ghrelin and adiponectin concentrations in young fit racehorses versus mature unfit standardbredsMary E Gordon
Rutgers, The State University of New Jersey, Equine Science Center, Department of Animal Sciences, 84 Lipman Drive, New Brunswick, NJ 08901, USA
Vet J 173:91-100. 2007....
- Secretory proteins as potential semiochemical carriers in the horseBarbara D'Innocenzo
Dipartimento di Chimica e Biotecnologie Agrarie, Universita di Pisa, 56124 Pisa, Italy
Biochemistry 45:13418-28. 2006Two soluble proteins were isolated as major secretory products of horse sweat and of the parotid gland and characterized for structural and functional properties...
- Allelic heterogeneity at the equine KIT locus in dominant white (W) horsesBianca Haase
Institute of Genetics, Vetsuisse Faculty, University of Berne, Berne, Switzerland
PLoS Genet 3:e195. 2007..We determined the sequence and genomic organization of the approximately 82 kb equine KIT gene...
- A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horsesS A Brooks
Department of Veterinary Science, University of Kentucky, Lexington, KY, USA
Cytogenet Genome Res 119:225-30. 2007..Here, we report TO associated with a large paracentric chromosome inversion on horse chromosome 3...
- A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horseGerli Rosengren Pielberg
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
Nat Genet 40:1004-9. 2008..The Gray horse provides a notable example of how humans have cherry-picked mutations with favorable phenotypic effects in ..
- Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus)Rebecca R Bellone
Department of Biology, University of Tampa, Tampa, FL 33606, USA
Genetics 179:1861-70. 2008..Decreased expression of TRPM1 in the eye and the skin may alter bipolar cell signaling as well as melanocyte function, thus causing both CSNB and LP in horses...
- Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liverH K DiMaio Knych
K L Maddy Equine Analytical Chemistry Laboratory, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, West Health Science Drive, Davis, CA 95616, USA
Biochem Pharmacol 76:904-11. 2008..In the horse, the presence of a member of the CYP2D family has been suggested from studies with equine liver microsomes, however its presence has not been definitively proven...
- Equine Multiple Congenital Ocular Anomalies maps to a 4.9 megabase interval on horse chromosome 6Lisa S Andersson
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
BMC Genet 9:88. 2008b>Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome consists of a diverse set of abnormalities predominantly localized to the frontal part of the eye...
- INHBA-associated markers as candidates for stallion fertilityK Giesecke
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Germany
Reprod Domest Anim 45:342-7. 2010..This is the first report on INHBA as an associated candidate gene with the LSM of stallions and the paternal and embryonic component of BVs for the pregnancy rate per oestrus...
- Evaluation of SPATA1-associated markers for stallion fertilityK Giesecke
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, 30559 Hannover, Germany
Anim Genet 40:359-65. 2009..fertility is an economically important trait because the use of artificial insemination is increasing in the horse industry and superior sires are used more intensely...
- Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterizationH K DiMaio Knych
K L Maddy Equine Analytical Chemistry Laboratory, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, West Health Science Drive, Davis, CA 95616, USA
Arch Biochem Biophys 485:49-55. 2009..Accordingly, a cytochrome P450 monooxygenase in the 2C family was cloned from an equine liver, sequenced and expressed in a baculovirus expression system...
- Latherin: a surfactant protein of horse sweat and salivaRhona E McDonald
Ecology and Evolutionary Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
PLoS ONE 4:e5726. 2009..latherin, determined from cDNA analysis, is highly conserved across four geographically dispersed equid species (horse, zebra, onager, ass), and is similar to a family of proteins only found previously in the oral cavity and ..
- Evaluation of prolactin receptor (PRLR) as candidate gene for male fertility in Hanoverian warmblood horsesK Giesecke
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany
Reprod Domest Anim 45:e124-30. 2010..Screening the equine PRLR gene for polymorphisms in Hanoverian stallions revealed two single nucleotide polymorphisms (SNPs)...
- Genome sequence, comparative analysis, and population genetics of the domestic horseC M Wade
Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA
Science 326:865-7. 2009We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication...
- Protein collective motions coupled to ligand migration in myoglobinYasutaka Nishihara
Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto Japan
Biophys J 98:1649-57. 2010....
- Whole-genome SNP association in the horse: identification of a deletion in myosin Va responsible for Lavender Foal SyndromeSamantha A Brooks
Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America
PLoS Genet 6:e1000909. 2010..LFS has been primarily diagnosed in a subgroup of the Arabian breed, the Egyptian Arabian horse. The condition is characterized by multiple neurological abnormalities and a dilute coat color...
- Localization of insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR) in equine testesM J Yoon
Department of Animal Science, University of California, Davis, CA, USA
Reprod Domest Anim 46:221-8. 2011..Immunolabelling of IGF-I and IGF-IR was not observed in Sertoli cells. In conclusion, IGF-I is localized in equine spermatogenic and Leydig cells, and IGF-IR is present in spermatogonia, spermatocytes and Leydig cells, suggesting ..
- Molecular cloning, expression, and initial characterization of members of the CYP3A family in horsesHeather K DiMaio Knych
California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California Davis, West Health Science Drive, Davis, CA 95616, USA
Drug Metab Dispos 38:1820-7. 2010The use of performance-enhancing drugs in the horse racing industry combined with the need for more rational approaches in the use of therapeutic agents in equids necessitates additional studies on the spectrum, content, and catalytic ..
- A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorsesEmmeline W Hill
Animal Genomics Laboratory, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
BMC Genomics 11:552. 2010..It is widely recognized that inherited variation in physical and physiological characteristics is responsible for variation in individual aptitude for race distance, and that muscle phenotypes in particular are important...
- Comparative human-horse sequence analysis of the CYP3A subfamily gene clusterA Schmitz
Division Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland
Anim Genet 41:72-9. 2010..We report here the genomic organization of the equine CYP3A gene cluster as well as a comparative analysis with the human CYP3A gene cluster...
- Increased cartilage oligomeric matrix protein concentrations in equine digital flexor tendon sheath synovial fluid predicts intrathecal tendon damageMatthew R W Smith
Royal Veterinary College, Equine Referral Hospital, North Mymms, UK
Vet Surg 40:54-8. 2011..To evaluate digital flexor tendon sheath (DFTS) synovial fluid cartilage oligomeric matrix protein (COMP) concentrations as a molecular marker for intrathecal pathology...
- Functional expression of the extracellular calcium sensing receptor (CaSR) in equine umbilical cord matrix size-sieved stem cellsNicola Antonio Martino
Department of Animal Production, Faculty of Biotechnological Sciences, University of Bari, Valenzano, Bari, Italy
PLoS ONE 6:e17714. 2011..and the calcimimetic NPS R-467, a known calcium-sensing receptor (CaSR) agonist, on growth/proliferation of two equine size-sieved umbilical cord matrix mesenchymal stem cell (eUCM-MSC) lines...
- Tissue-specific expression of the calcium transporter genes TRPV5, TRPV6, NCX1, and PMCA1b in the duodenum, kidney and heart of Equus caballusInho Hwang
Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361 763, Republic of Korea
J Vet Med Sci 73:1437-44. 2011..mRNA and protein expression of these calcium transporter genes in the duodenum, kidney and heart of the horse (Equus caballus) was examined using reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis...
- Identification of a mutation associated with fatal Foal Immunodeficiency Syndrome in the Fell and Dales ponyLaura Y Fox-Clipsham
Animal Health Trust, Newmarket, UK
PLoS Genet 7:e1002133. 2011..Having identified the associated gene, we are now able to eradicate FIS from equine populations by informed selective breeding.
- Latherin and other biocompatible surfactant proteinsMalcolm W Kennedy
Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow G12 8QQ, UK
Biochem Soc Trans 39:1017-22. 2011..It may consequently have a dual role in horse sweat in both evaporative cooling and controlling microbial growth in the pelt that would otherwise be resourced ..
- Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horsesElisabeth Sundström
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
Pigment Cell Melanoma Res 25:28-36. 2012..These results provide strong support for the causative nature of the duplication and constitute an explanation for the melanocyte-specific effects of the Grey allele...
- Congenital stationary night blindness is associated with the leopard complex in the Miniature HorseLynne S Sandmeyer
Department of Small Animal Clinical Sciences, University of Saskatchewan, Quill Lake, Saskatchewan, Canada
Vet Ophthalmol 15:18-22. 2012To determine if congenital stationary night blindness (CSNB) exists in the Miniature Horse in association with leopard complex spotting patterns (LP), and to investigate if CSNB in the Miniature Horse is associated with three single ..
- Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horsesRegula Hauswirth
Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland
PLoS Genet 8:e1002653. 2012..Some, but not all, splashed white horses are deaf. We analyzed a Quarter Horse family segregating for the splashed white coat color...
- Mutation in cyclophilin B that causes hyperelastosis cutis in American Quarter Horse does not affect peptidylprolyl cis-trans isomerase activity but shows altered cyclophilin B-protein interactions and affects collagen foldingYoshihiro Ishikawa
Research Department, Shriners Hospital for Children, Portland, Oregon 97239, USA
J Biol Chem 287:22253-65. 2012..B found in the American Quarter Horse leads to autosomal recessive hyperelastosis cutis, also known as hereditary equine regional dermal asthenia...
- Equine cytochrome P450 2B6--genomic identification, expression and functional characterization with ketamineL M Peters
Division Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University Bern, Laenggassstr 124, 3012 Bern, Switzerland
Toxicol Appl Pharmacol 266:101-8. 2013..CYPs have been thoroughly examined in humans and laboratory animals, but little is known about equine CYPs. The characterization of equine CYPs is essential for a better understanding of drug metabolism in horses...
- Genome-wide association study implicates testis-sperm specific FKBP6 as a susceptibility locus for impaired acrosome reaction in stallionsTerje Raudsepp
Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, USA
PLoS Genet 8:e1003139. 2012..Here we conducted Equine SNP50 Beadchip genotyping and GWAS using 7 IAR-affected and 37 control Thoroughbred stallions...
- Stage-dependent DAZL localization in stallion germ cellsH J Jung
Department of Animal and Biotechnology Science, College of Animal Science, Kyungpook National University, Sangju 742 711, Republic of Korea
Anim Reprod Sci 147:32-8. 2014..We conclude that DAZL can be used as a marker of pre-meiotic germ cells in stallions...
- Post-mortem stability of RNA in skeletal muscle and adipose tissue and the tissue-specific expression of myostatin, perilipin and associated factors in the horsePhilippa K Morrison
University of Liverpool, Department of Obesity and Endocrinology, Faculty of Health and Life Sciences, Leahurst Campus, Neston, Wirral, United Kingdom
PLoS ONE 9:e100810. 2014Obesity, a major concern for equine welfare, is highly prevalent in the leisure horse population. Skeletal-muscle and adipose tissues are important determinants of maintenance energy requirements...
- Molecular cloning and characterization of phospholipase C zeta in equine sperm and testis reveals species-specific differences in expression of catalytically active proteinS J Bedford-Guaus
Departments of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Biol Reprod 85:78-88. 2011..of this research were to clone and characterize the intracellular Ca(2+)-releasing activity and expression of equine PLCZ in sperm and testis...
- Nucleotide sequence of a cDNA clone of the horse (Equus caballus) DRA geneD Albright
Department of Veterinary Sciences, University of Kentucky, Lexington 40536 0084
Immunogenetics 34:136-8. 1991
- X-ray and primary structure of horse serum albumin (Equus caballus) at 0.27-nm resolutionJ X Ho
NASA, Marshall Space Flight Center, Huntsville, AL 35812
Eur J Biochem 215:205-12. 1993The amino-acid sequence and three-dimensional structure of equine serum albumin have been determined. The amino-acid sequence was deduced from cDNA isolated from equine liver...
- A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formationE K Shin
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
J Immunol 158:3565-9. 1997The equine SCID defect is more severe than its murine counterpart in that SCID foals are incapable of forming either coding or signal joints, whereas SCID mice manifest normal signal joint formation...
- Biochemical characterization and surfactant properties of horse allergensH Goubran Botros
Unite d Immuno Allergie, Institut Pasteur, Paris France
Eur J Biochem 268:3126-36. 2001A new allergen from horse dander, Equ c 5 has been purified. Its biochemical and biophysical properties have been characterized and compared with those of Equ c 1, Equ c 2 and Equ c 4...
- Structure of equine 2'-5'oligoadenylate synthetase (OAS) gene family and FISH mapping of OAS genes to ECA8p15-->p14 and BTA17q24-->q25A A Perelygin
Biology Department, Georgia State University, Atlanta, GA 30302 4010, USA
Cytogenet Genome Res 111:51-6. 2005..In this study, the structures of four equine OAS genes were determined using DNA sequences derived from fifteen cDNA and four BAC clones...
- Genomic characterization of MHC class I genes of the horseRebecca L Tallmadge
James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Immunogenetics 57:763-74. 2005The availability of a contig of bacterial artificial chromosome (BAC) clones spanning the equine major histocompatibility complex (MHC) made possible a detailed analysis of horse MHC class I genes...
- Assignment of the Equus caballus interleukin 8 gene (IL8) to chromosome 3q14.2-->q14.3 by in situ hybridizationS G Nergadze
Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
Cytogenet Genome Res 112:341B. 2006
- The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and ArtiodactylaAndrey A Perelygin
Biology Department, Georgia State University, P O Box 4010, Atlanta, GA 30302 4010, USA
J Mol Evol 63:562-76. 2006..pig, and dog OAS genes were amplified, sequenced and compared with each other and with those in the human, mouse, horse, and chicken genomes...
- A missense mutation in PMEL17 is associated with the Silver coat color in the horseEmma Brunberg
Dept of Medical Biochemistry and Microbiology, Uppsala University, SE 751 24 Uppsala, Sweden
BMC Genet 7:46. 2006The Silver coat color, also called Silver dapple, in the horse is characterized by dilution of the black pigment in the hair. This phenotype shows an autosomal dominant inheritance...
- Analysis of peripheral blood mononuclear cells gene expression in endurance horses by cDNA-AFLP techniqueKatia Cappelli
Centro di Studio del Cavallo Sportivo, Facolta di Medicina Veterinaria, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy
Res Vet Sci 82:335-43. 2007..The mRNAs sequences obtained were included in the GenBank database as Equus caballus interleukin 8 (IL8), E. caballus retinoblastoma binding protein 6 mRNA (RBBP6), E...
- Clenbuterol affects the expression of messenger RNA for interleukin 10 in peripheral leukocytes from horses challenged intrabronchially with lipopolysaccharidesR van den Hoven
Department of Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases, Institute of Medical Chemistry, Veterinary University of Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
Vet Res Commun 30:921-8. 2006..Thus the results of this study indicated that clenbuterol can modulate the expression of IL-10 mRNA in peripheral white blood cells in those horses with small airway diseases that have been exposed to LPS...
- Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genesJonathan J Rios
Department of Animal Science, Texas A and M University, 2471 TAMU, College Station, Texas 77843, USA
BMC Genomics 8:313. 2007..No polymorphisms have yet been identified in either the equine OAS1 or RNASEL genes for use in similar case-control studies.
- Exercise-induced up-regulation of MMP-1 and IL-8 genes in endurance horsesKatia Cappelli
Pathology, Diagnostic and Veterinary Clinic Department, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy
BMC Physiol 9:12. 2009The stress response is a critical factor in the training of equine athletes; it is important for performance and for protection of the animal against physio-pathological disorders...
- Fine-mapping and mutation analysis of TRPM1: a candidate gene for leopard complex (LP) spotting and congenital stationary night blindness in horsesRebecca R Bellone
Department of Biology, University of Tampa, Tampa, FL 33611, USA
Brief Funct Genomics 9:193-207. 2010..Further, this work has identified several potential regulatory elements of the TRPM1 gene that should be investigated further in this and other species...
- A preliminary study on the effect of wounding on transforming growth factor-β1 and cartilage oligomeric matrix protein concentrations in the skin of horsesAndrew J Dart
Faculty of Veterinary Science, University of Sydney, Sydney, Australia
Vet Surg 40:59-65. 2011..To evaluate whether wound type or site influence the production of cartilage oligomeric matrix protein (COMP) and transforming growth factor β1 (TGF-β1), and determine if there is a correlation between TGF-β1and COMP during healing...
- Decreased expression of p63, a regulator of epidermal stem cells, in the chronic laminitic equine hoofR A Carter
Laminitis Institute, Department of Clinical Studies New Bolton Center, University of Pennsylvania School of Veterinary Medicine, PA, USA
Equine Vet J 43:543-51. 2011Abnormal epidermal stem cell regulation may contribute to the pathogenesis of equine chronic laminitis.
- Multiple congenital ocular anomalies in Icelandic horsesLisa S Andersson
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, SE 751 24 Uppsala, Sweden
BMC Vet Res 7:21. 2011..ocular defects are caused by a recent mutation that is restricted to horses that are related to the Rocky Mountain Horse breed...
- Comparative analysis of vertebrate EIF2AK2 (PKR) genes and assignment of the equine gene to ECA15q24-q25 and the bovine gene to BTA11q12-q15Andrey A Perelygin
Biology Department, Georgia State University, Atlanta, 30302, USA
Genet Sel Evol 38:551-63. 2006The structures of the canine, rabbit, bovine and equine EIF2AK2 genes were determined. Each of these genes has a 5' non-coding exon as well as 15 coding exons...
- Comparative mapping of 18 equine type I genes assigned by somatic cell hybrid analysisA R Caetano
University of California Davis, Veterinary Genetics Laboratory, Davis, California 95616 8744, USA
Mamm Genome 10:271-6. 1999..from consensus sequences highly conserved in mammalian species were used to amplify markers for synteny mapping 18 equine type I genes. These markers were used to screen a horse-mouse somatic cell hybrid panel (UCDavis SCH)...
- Probable reason why small strongyle EPG counts are returning "early" after ivermectin treatment of horses on a farm in Central KentuckyE T Lyons
Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY, 40546 0099, USA
Parasitol Res 104:569-74. 2009..from posttreatment (PT) worm count data, the current activity of ivermectin against small strongyles in a horse herd...
- The role of neutrophil chemotactic cytokines in the pathogenesis of equine chronic obstructive pulmonary disease (COPD)M Franchini
Institute of Veterinary Physiology, University of Zurich, Switzerland
Vet Immunol Immunopathol 66:53-65. 1998..1973. Chronic pulmonary disease in the horse, Equine Vet. J. 5, 26-33; Winder, N.C., Grünig, G., Hermann, M., Howald, B., von Fellenberg, R., 1989...
- Epidemiology of Trichinella infection in the horse: the risk from animal product feeding practicesK D Murrell
WHO FAO Collaborating Centre for Parasitic Zoonosis, Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University, 3 Ridebanevej, DK 1870 Frederiksberg Copenhagen, Denmark
Vet Parasitol 123:223-33. 2004A discovery in 2002 of a Trichinella spiralis-infected horse in Serbia offered an opportunity to conduct needed epidemiological studies on how horses, considered herbivores, acquire a meat-borne parasite...
- Anthelmintic resistance in cyathostomins of brood horses in Ukraine and influence of anthelmintic treatments on strongylid community structureTetyana A Kuzmina
Department of Parasitology, I I Schmalhausen Institute of Zoology NAS of Ukraine, vul B Khmelnitskogo 15, Kyiv 01601, Ukraine
Vet Parasitol 154:277-88. 2008In 2004-2006, 322 brood horses from 11 horse farms were examined using the faecal egg count reduction test (FECRT) to determine the presence and distribution of anthelmintic resistance in strongylids in Ukraine...
- Association of deficiency in antibody response to vaccine and heterogeneity of Ehrlichia risticii strains with Potomac horse fever vaccine failure in horsesS K Dutta
Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park 20742, USA
J Clin Microbiol 36:506-12. 1998Ehrlichia risticii is the causative agent of Potomac horse fever (PHF), which continues to be an important disease of horses. Commercial inactivated whole-cell vaccines are regularly used for immunization of horses against the disease...
- Facial hair whorls (trichoglyphs) and the incidence of motor laterality in the horseJack Murphy
Department of Life Sciences, University of Limerick, Limerick, Ireland
Behav Processes 79:7-12. 2008..Motor laterality in the horse affects locomotion and subsequently equine performance during training and may have inherent safety implications for equitation...
- Long-term memory for categories and concepts in horses (Equus caballus)Evelyn B Hanggi
Equine Research Foundation, Aptos, CA 95001, USA
Anim Cogn 12:451-62. 2009Three horses (Equus caballus) with a history of performing cognitive tasks including discrimination learning, categorization, and concept use were tested to evaluate their long-term memory (LTM) in three experiments...
- Visual laterality in the domestic horse (Equus caballus) interacting with humansKate Farmer
Centre for Social Learning and Cognitive Evolution, School of Psychology, University of St Andrews, St Andrews, Fife, Scotland, UK
Anim Cogn 13:229-38. 2010..As such lateralisation could provide important clues regarding the horse's cognitive processes, we investigated whether horses also show laterality in association with people...
- Validation of models for analysis of ranks in horse breeding evaluationAnne Ricard
INRA, UMR 1313, 78352 Jouy en Josas, France
Genet Sel Evol 42:3. 2010..The simulations involved 1000 horses with 10 to 50 performances per horse and 4 to 20 horses per event with unstructured and structured competitions.
- Horse domestication and conservation genetics of Przewalski's horse inferred from sex chromosomal and autosomal sequencesAllison N Lau
Department of Biology, The Pennsylvania State University, University Park, USA
Mol Biol Evol 26:199-208. 2009..fertile offspring, there is continued disagreement about the genetic relationship of the domestic horse (Equus caballus) to its endangered wild relative, Przewalski's horse (Equus przewalskii)...
- Characteristics of equine summer eczema with emphasis on differences between Finnhorses and Icelandic horses in a 11-year studyRaija E Hallamaa
Veterinary Clinic, Pisteenkaari 4, 03100 Nummela, Finland
Acta Vet Scand 51:29. 2009..b>Equine summer eczema seems to be aggravated by various combinations of environmental factors.
- Crib-biting in US horses: breed predispositions and owner perceptions of aetiologyJ D Albright
Departments of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Equine Vet J 41:455-8. 2009Crib-biting is an equine stereotype that may result in diseases such as colic. Certain breeds and management factors have been associated.
- Effects of a calm companion on fear reactions in naive test horsesJ W Christensen
Department of Animal Health, Welfare and Nutrition, Faculty of Agricultural Sciences, University of Aarhus, Tjele, Denmark
Equine Vet J 40:46-50. 2008In fear-eliciting situations, horses tend to show flight reactions that can be dangerous for both horse and man. Finding appropriate methods for reducing fearfulness in horses has important practical implications.
- Microbial source tracking by DNA sequence analysis of the Escherichia coli malate dehydrogenase geneKathryn M Ivanetich
University of California San Francisco, Biomolecular Resource Center and Department of Pharmaceutical Chemistry, Surge 104, 90 Medical Center Way, San Francisco, CA 94143 0541, USA
J Microbiol Methods 67:507-26. 2006..295 fecal isolates (52 horse, 50 deer, 72 dog, 52 seagull and 69 human isolates) were sequenced and analyzed...
- Equine clinical genomics: A clinician's primerM M Brosnahan
Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, New York, USA
Equine Vet J 42:658-70. 2010..to the rapidly evolving field of clinical genomics with a vision of improving the health and welfare of the domestic horse. For 15 years a consortium of veterinary geneticists and clinicians has worked together under the umbrella of ..
- Effect of sperm cryopreservation and treatment with calcium ionophore or heparin on in vitro fertilization of horse oocytesH Alm
Department of Reproductive Biology, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
Theriogenology 56:817-29. 2001Little information is available on methods of sperm capacitation for IVF in the horse. In this study, we summarized results of several independent trials that compared acrosome reaction, hyperactivation and chromatin integrity of fresh ..
- 13C NMR spectroscopic and X-ray crystallographic study of the role played by mitochondrial cytochrome b5 heme propionates in the electrostatic binding to cytochrome cM J Rodríguez-Marañón
Department of Chemistry, Oklahoma State University, Stillwater 74078, USA
Biochemistry 35:16378-90. 1996..membrane (OM) cytochrome b5 heme propionate groups in the electrostatic binding between OM cytochrome b5 and horse heart cytochrome c was investigated by 13C NMR spectroscopy and X-ray crystallography...
- Selective inhibition of butyrylcholinesterase in vivo in horses by the feed-through larvacide EquitrolSubramanya Karanth
Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, 264 McElroy Hall, Stillwater, OK 74078, USA
Regul Toxicol Pharmacol 50:200-5. 2008..g., Equitrol) for fly control around horse stables...
- Use of reverse transcriptase-polymerase chain reaction (RT-PCR) and dot-blot hybridisation for the detection and identification of African horse sickness virus nucleic acidsS Zientara
Centre National d Etudes Veterinaires et Alimentaires, Laboratoire Central de Recherches Veterinaires, Maisons Alfort, France
Arch Virol Suppl 14:317-27. 1998A coupled reverse transcriptase-polymerase chain reaction assay (RT-PCR) for the detection of African horse sickness virus (AHSV) dsRNA, has been developed using genome segment 7 as the target template for primers...
- Optical spectroscopy of nicotinoprotein alcohol dehydrogenase from Amycolatopsis methanolica: a comparison with horse liver alcohol dehydrogenase and UDP-galactose epimeraseS R Piersma
Department of Microbiology and Enzymology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
Biochemistry 37:3068-77. 1998..maxima compared to other NADH-dehydrogenase complexes, but comparable to that observed for NADH bound to horse liver alcohol dehydrogenase...
- Evaluation of parasiticidal activity of fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate in horse foals with emphasis on ascarids (Parascaris equorum) in field studies on five farms in Central Kentucky in 2007E T Lyons
Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546 0099, USA
Parasitol Res 103:287-91. 2008b>Horse foals on five farms in Central Kentucky were used in field studies in 2007 evaluating activity of paste formulations of four compounds (fenbendazole-FBZ, ivermectin-IVM, oxibendazole-OBZ, and pyrantel pamoate-PRT) against internal ..
- The transmission and geographical spread of African horse sickness and bluetongue virusesP S Mellor
Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, U K
Ann Trop Med Parasitol 89:1-15. 1995African horse sickness virus (AHSV) and bluetongue virus (BTV) are dsRNA viruses within the genus Orbivirus. Both are able to cause non-contagious, infectious arthropod-borne diseases in their respective vertebrate hosts...
- Cross-reactivity of Japanese encephalitis virus-vaccinated horse sera in serodiagnosis of West Nile virusJiro Hirota
Research Team for Advanced Biologicals, National Institute of Animal Health, National Agriculture and Food Research Organization, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
J Vet Med Sci 72:369-72. 2010..However, the cross-reactivity level of JEV-vaccinated horse sera in the serodiagnosis of West Nile virus (WNV) has not been clarified...
- Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteriesD Prieto
Departamento de Fisiologia, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
Br J Pharmacol 123:1609-20. 19981. Penile small arteries (effective internal lumen diameter of 300 600 microm) were isolated from the horse corpus cavernosum and mounted in microvascular myographs in order to investigate the mechanisms underlying the endothelium-..
- Detection of testosterone, nandrolone and precursors in horse hairP Anielski
Institute of Doping Analysis and Sports Biochemistry, Dresdner Str 12, 01731 Kreischa, Germany
Anal Bioanal Chem 383:903-8. 2005Growing interest among several horse-breeder associations has initiated the development of a screening procedure to test for anabolic agents in hair, which has the advantage over blood and urine specimens of allowing long-term detection...
- Clinical trials of efficacy of praziquantel horse paste 9% against tapeworms and its safety in horsesJ Owen D Slocombe
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ont, Canada N1G 2W1
Vet Parasitol 144:366-70. 2007..naturally infected with tapeworms was to confirm in clinical trials the efficacy and safety of a praziquantel horse paste 9%. The field trials were conducted in 1997 and 1998 in Canada, France, Germany and New Zealand...
- Sexual behavior and ejaculate characteristics in Pêga donkeys (Equus asinus) mounting estrous horse mares (Equus caballus)I F Canisso
Equid Breeding Center, Department of Animal Science, Federal University of Vicosa, Vicosa, Minas Gerais, Brazil
Theriogenology 73:56-63. 2010..of donkey stallions (jacks; Equus asinus) during on-farm semen collection using estrous horse mares (mares; Equus caballus); (ii) compare behavior of young (less experienced) versus older (more experienced) jacks; (iii) determine ..
- Vitamin D(3) synthesis in the entire skin surface of dairy cows despite hair coverageL Hymøller
Department of Animal Health and Bioscience, Aarhus University, Faculty of Agricultural Sciences, Blichers alle 20, Box 50, DK 8830 Tjele, Denmark
J Dairy Sci 93:2025-9. 2010..The treatments were horse blanket (cows fitted with horse blankets), udder cover (cows fitted with udder covers, horse blanket+udder cover (..
- Protective immunization of horses with a recombinant canarypox virus vectored vaccine co-expressing genes encoding the outer capsid proteins of African horse sickness virusAlan J Guthrie
Equine Research Centre, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
Vaccine 27:4434-8. 2009..with a commercial recombinant canarypox virus vectored vaccine expressing the haemagglutinin genes of two equine influenza H3N8 viruses was seronegative to AHSV and following infection with virulent AHSV-4 developed pyrexia, ..
- Heterogeneity of the neuropeptide Y (NPY) contractile and relaxing receptors in horse penile small arteriesDolores Prieto
Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
Br J Pharmacol 143:976-86. 2004..of NPY upon electrical field stimulation (EFS)- and noradrenaline (NA)-elicited contractions were investigated in horse penile small arteries...
- Antigenic profile of African horse sickness virus serotype 4 VP5 and identification of a neutralizing epitope shared with bluetongue virus and epizootic hemorrhagic disease virusJ L Martinez-Torrecuadrada
Inmunologia y Genetica Aplicada SA Ingenasa, Hnos Garcia Noblejas 41, Madrid, 28037, Spain
Virology 257:449-59. 1999African horse sickness virus (AHSV) causes a fatal disease in horses. The virus capsid is composed of a double protein layer, the outermost of which is formed by two proteins: VP2 and VP5...
- Folding of horse cytochrome c in the reduced stateA K Bhuyan
School of Chemistry, University of Hyderabad, Hyderabad, 500046, India
J Mol Biol 312:1135-60. 2001Equilibrium and kinetic folding studies of horse cytochrome c in the reduced state have been carried out under strictly anaerobic conditions at neutral pH, 10 degrees C, in the entire range of aqueous solubility of guanidinium ..
- Purification and characterization of cysteine protease from germinating cotyledons of horse gramRajeswari Jinka
Center for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
BMC Biochem 10:28. 2009..To study the mechanism of protein mobilization, undertaken the task of purifying and characterizing proteases, which occur transiently in germinating seeds of horse gram.
- Ulcerative cystitis associated with phenylbutazone administration in two horsesMonica Aleman
William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
J Am Vet Med Assoc 239:499-503. 2011A 15-year-old Quarter Horse gelding and a 26-year-old Thoroughbred gelding were evaluated because of hematuria of 4 to 6 days' duration following prolonged oral administration of phenylbutazone.
- Crosslink augmentation to resist snoring and obstructive sleep apnea syndromeThomas P Hedman; Fiscal Year: 2013..a wind tunnel test system will be developed to measure the vibration magnitude and oscillation frequency of horse soft palates;3) the wind tunnel will be used to quantify reduction of vibration in horse soft palates following ..
- Epigenetics: A Novel Approach in Primary ImmunodeficienciesMARIA JULIA BEVILAQUA FELIPPE; Fiscal Year: 2010..The goal of this proposal is to introduce and investigate the mechanism of disease in a natural equine model of CVID, for direct application in diagnostics and management of human patients with primary humoral ..
- REGULATION OF MHC GENES IN TROPHOBLASTDOUGLAS ANTCZAK; Fiscal Year: 1999..Advantages of the equine model include non- surgical recovery of conceptuses at any stage of development between days 6 and 36 after ..
- A novel model for the study of primary immunodeficiency: the equine CVIDMARIA FLAMINIO; Fiscal Year: 2009..Although these equine patients do not respond to tetanus-toxoid vaccination with specific-immunoglobulin production, they do respond to ..
- Virulence and Immunity of Granulocytic EhrlichiaeJOHN DUMLER; Fiscal Year: 2005..mechanisms of granulocytic ehrlichiae, we will use a convenient mouse model and validate results in the horse model that mostly closely simulates human disease. Thus, we propose to: 1...
- Development of Medical Countermeasures to Ricin PoisoningTHOR BORGFORD; Fiscal Year: 2009..During the course of the equine antidote development, novel approaches will be investigated to test and improve the effectiveness of an antibody-..
- A MODEL OF BRONCHIAL HYPERREACTIVITYN Robinson; Fiscal Year: 1990..Our principal aims are to determine if horse and pony airway smooth muscle receive sympathetic innervation and possesses a nonadrenergic inhibitory nervous ..
- Cytotoxic T Lymphocytes in immunity to Rhodococcus equiKRISTIN HASEL; Fiscal Year: 2003..The co-sponsors have experience in performing state-of-the-art research involving equine cytotoxic T lymphocytes (CTLs) and pulmonary immunology of Rhodococcus equi, as well as the training of PhD ..
- Shonga Ska: Sacred Horse Society Drug Prevention ProgramLESLIE WHITBECK; Fiscal Year: 2006..The proposed program will be based on a blend of equine-assisted therapy techniques and Omaha traditions pertaining to the horse in their culture...
- Etiologic studies on EMND: An animal model for ALSHussni Mohammed; Fiscal Year: 2004b>Equine motor neuron disease (EMND) is a neurodegenerative disorder of the horse characterized by progressive weakness, fasciculations, muscle wasting, and weight loss...
- IRON CHELATOR DELIVERY IN RED BLOOD CELL GHOSTSRalph Green; Fiscal Year: 1980..Using the RBCG as a Trojan Horse for delivery of DF into RE cells, we will measure the rates of iron loss in normal, iron-loaded and ..
- Howard E Gendelman; Fiscal Year: 2016..Monthly nanoART injection, to subcellular sites of viral replication is possible We posit that this "Trojan Horse" MP carriage of the drug formulations can facilitate long-lived storage depots, in liver and spleen, resulting in ..
- Effects of apoptotic epithelial cell engulfment on mucosal inflammationPeter B Ernst; Fiscal Year: 2010..they carry an intracellular infection with Salmonella enterica serovar Typhimurium may act as a microbial "Trojan horse" that transports internalized bacteria into the APC thereby stimulating inflammatory responses...
- An Exotendon Prosthesis to Improve Walking for Lower Limb AmputeesBRIAN GLAISTER; Fiscal Year: 2012..Borrowing from horse anatomy where short muscles interact with long tendons that stretch across multiple joints, exotendons can store ..
- Jaymie R Meliker; Fiscal Year: 2014..the late 20th century resulted in increased cadmium in foodstuffs and tobacco, earning it notoriety as "the Trojan horse of the green revolution"...
- Marvin J Miller; Fiscal Year: 2016..and virulence can provide new approaches to development of antiTB agents while assessing the underexplored "Trojan Horse" approach. Aim 3. Evaluate all lead compounds using appropriate in vitro and in vivo pre-clinical studies...
- Comparative analysis of the 4D encoding of regulatory networks in stem cellsSeyed Ali Mortazavi; Fiscal Year: 2013..demonstrate the power of these methods, we will apply them to study the differentiation of existing human, mouse, horse and dog stem cells into cardiomyocytes and neurons in order to understand the role, conservation and dynamics of ..
- John C Schimenti; Fiscal Year: 2016..Their research concentrates primarily on vertebrate organisms, including mice, zebrafish, dog, horse, and humans, but also represented are C. elegans and Drosophila...
- Acquisition of a Q-TOF Mass SpectrometerWei Li; Fiscal Year: 2012..The Bruker Esquire-LC/MS system has been well maintained and is the work horse supporting extensive small-molecular drug discovery and drug delivery programs at UTHSC in the areas of cancer, ..
- Jason A Carlyon; Fiscal Year: 2016..A. phagocytophilum converts its host neutrophil into a Trojan horse that facilitates pathogen replication and dissemination...
- Metachromatic Leukodystrophy Enzyme Drug DevelopmentKA WAI HUI; Fiscal Year: 2012..The present work will re-engineer human ASA to enable transport across the BBB using a molecular Trojan horse technology...
- Biopsy and Freezing of Later-stage Mouse Blastocysts Using the Dracula PipetteEdward E Schmidt; Fiscal Year: 2013..for the first time, dramatic advances in cryopreservation of large hatched embryos such as those of the llama and horse. Now, GeneSearch is scaling down the size of the tool, using new materials for some parts, and improving its ..
- The roles of Anaplasma phagocytophilum surface proteins in cellular invasionJason A Carlyon; Fiscal Year: 2012..A. phagocytophilum converts its host neutrophil into a Trojan Horse that facilitates pathogen replication and dissemination...
- Flow Cytometry Cell SorterZUHAIR BALLAS; Fiscal Year: 2009..It serves as a work horse for cloning, isolating cells expressing fluorescent protein markers, multi-color cell sorting of rare cell ..
- Characterization of Tau Lymphocyte Modulation in PregnancyLEELA E NORONHA; Fiscal Year: 2010..This project takes advantage of the naturally occurring modulation of maternal immunity in equine pregnancy that offers unique insights into the fetal-maternal immunological relationship in mammals...
- Ruben J Boado; Fiscal Year: 2014..The HIRMAb part of the HIRMAb-TNFR fusion protein acts as a molecular Trojan horse to ferry the fused decoy receptor across the BBB via receptor-mediated transport on the endogenous BBB insulin ..
- KA WAI HUI; Fiscal Year: 2014..The ASA enzyme is fused to a BBB molecular Trojan horse, which is a genetically engineered peptidomimetic monoclonal antibody (MAb) against an endogenous BBB peptide ..
- Enzyme replacement therapy of the brain in Mucopolysaccharidosis Type IIZhiqiang Lu; Fiscal Year: 2013..The IDS is genetically fused to a BBB molecular Trojan horse, which is a genetically engineered peptidomimetic monoclonal antibody (MAb) against an endogenous BBB peptide ..
- ROBERT P BOWSER; Fiscal Year: 2015..Iron Horse Diagnostics, Inc...
- High Resolution MR Imaging of Damaged Myocardium in Patients with ArrhythmiaBenoit Desjardins; Fiscal Year: 2010..impact on quality of life, as the discharge from an ICD is described as similar to being kicked in the chest by a horse. Radiofrequency ablation under guidance of cardiac electrical mapping, a therapy rapidly growing in importance and ..
- MHC suppression as a model for transplant toleranceArnar Geirsson; Fiscal Year: 2007..In veterinary experiments, a zebra ovum implanted in a horse resulted in the birth of a normal zebra, yet there is a species difference...
- Nanometer-scale protein patterns for cell culture by laser inactivationWILLIAM HEINZ; Fiscal Year: 2009..enabled the significant advances in public health, such as the discovery of the polio vaccine, and are the work horse of modern biomedical sciences...
- Manufacturing of Trojan Horse-TNFR Decoy Receptor Fusion ProteinRuben J Boado; Fiscal Year: 2012..The HIRMAb part of the HIRMAb-TNFR fusion protein acts as a molecular Trojan horse to ferry the fused decoy receptor across the BBB via receptor-mediated transport on the endogenous BBB insulin ..
- OXYGEN RADICAL-ENZYME SCAVENGING IN ONCHOCERCAEric James; Fiscal Year: 1990..GSH-Px) principally in mf but also in adult worms and third stage larvae (L3s) of Onchocerca cervicalis, a common equine parasite in the USA which is very closely related to O. volvulus of man...
- Neonatal Phototherapy / Bilirubin ExcretionDAVID LIGHTNER; Fiscal Year: 2007..5) Design and synthesize bilirnbin fluorophores and MRI-sensitive imaging agents and Trojan Horse vehicles for research and clinical applications involving pigment distribution, hepatic uptake, clearance and drug ..
- Borrelia lipoproteins with the cerebral microcirculationDiego Cadavid; Fiscal Year: 2007..Pathogens may cross the BBB through paracellular, transcellular, and/or Trojan horse mechanisms...
- Ferritin and Iron Nutrition in Health and DiseaseElizabeth Theil; Fiscal Year: 2005..Legume seeds consumed by humans are rich in iron and ferritin. Soybean seed iron (largely ferritin) and horse spleen ferritin are available iron sources for iron deficient rats...
- Development of Therapeutics to Eliminate HIVJohn J Osterhout; Fiscal Year: 2010..which represents a first step toward the attainment of our long term goal, is the development of Trojan horse inhibitors (THIs) that are activated by HIV protease and serve to kill the cells in which the HIV is attempting to ..
- Bone marrow monocyte output and virus import into the CNS in acute SIV infectionMichael McChesney; Fiscal Year: 2009..SIVmac251 infection prevents virus import into the Central Nervous System (CNS) and monocytes'role as `Trojan Horse'for virus brain entry...
- Re-Engineering Blood-Borne Erythropoietin for Targeted DeliveryRuben J Boado; Fiscal Year: 2011..The HIRMAb part of the HIRMAb-EPO fusion protein acts as a molecular Trojan horse to ferry the fused EPO across the BBB via receptor-mediated transport on the endogenous BBB insulin receptor...
- Gallium, a potential new therapeutic for CF airway infectionsPradeep K Singh; Fiscal Year: 2010Here we investigate a novel antimicrobial approach using the metal gallium (Ga) as a "Trojan horse" to disrupt bacterial Fe metabolism...
- ELECTRON TRANSFER IN DYNAMIC PROTEIN COMPLEXESJAMES ERMAN; Fiscal Year: 2009..very well characterized with crystal structures available for 1:1 complexes of yeast iso-1 cytochrome c/CcP and horse cytochrome c/CcP, as well as for the individual proteins...
- OCCUPATIONAL ASTHMA ASOCIATED WITH SEAFOOD PROCESSINGThomas Robins; Fiscal Year: 2001..exposure to lobster and saltwater bony fish (pilchard, Cape anchovy, mackerel, light fish, redeye, Cape horse mackerel, lantern fish) and health outcomes expected to be mediated through an immunologic IgE mechanism...
- Replacement of Microscopy Core 10-years-old Zeiss LSM-510 with a new LSM-710Phong T Tran; Fiscal Year: 2010..John Murray). This microscope has been a work-horse for more than 10 years, has contributed to the research of more than 30 NIH-funded laboratories, and has directly ..
- TRANSPORT OF AN E COLI VIRULENCE FACTOR--THE K1 CAPSULERichard Silver; Fiscal Year: 2000..investigator proposes to purify polysialic acid from cells using an immunoaffinity column of specifically purified horse antiserum, and polyclonal anti-KpsT antibody will be used to detect KpsT attached to polysaccharide...
- 15TH INTERNATIONAL HERPESVIRUS WORKSHOPLEONARD ROSENTHAL; Fiscal Year: 1990..Marek's Disease virus), swine (Pseudorabies virus), and dairy (bovine rhinotracheitis virus) industries and the equine herpesviruses cause significant losses to horse breeders...
- PEROXIDASES, CATALASES, AND CYTOCHROME P-450ZBIGNIEW KORSZUN; Fiscal Year: 1991..peroxides and ex- hibits catalytic intermediates which are similar in structure and function to catalase and horse radish peroxidase...
- CHEMISTRY OF INHIBIN AND RELATED HORMONESDARRELL WARD; Fiscal Year: 1990..Our studies will utilize the genomic cosmid libraries we have prepared from pig, human, horse, cow, mouse, and chicken to evaluate the distribution of the inhibin gene(s) in these species...
- AUTONOMIC-EPITHELIAL INTERACTIONS IN AIRWAY DISEASERichard Broadstone; Fiscal Year: 1990In Phase I of this award I will obtain a Ph.D. in physiology investigating autonomic regulation of horse airways...
- 800 MHz Triple Resonance Observe (TXO) Detection CryoProbeGerhard Wagner; Fiscal Year: 2010..cryoplatform and two triple-resonance cryoprobes that are optimized for 1H detection (TCI), which will be the work horse for 3D ad 4D dispersed NOESY experiments, and a 13C/15N detection optimized probe, which will be used for novel ..
- GRANULOCYTIC EHRLICHIAS IN TICKS AND TICK CELL CULTUREUlrike Munderloh; Fiscal Year: 2002..Last year, two research groups isolated the etiologic agent from human patients (Goodman et al. 1996) and a horse (Munderloh et al...
- Vaccine discovery for Burkholderia via protection screenJEFFREY NORDSTROM; Fiscal Year: 2003Glanders is a severe disease that has already been used as a bioweapon. It is naturally an equine disease but can be administered by aerosol for efficient human infection...
- LASER SCANNING CONFOCAL MICROSCOPENigel Bunnett; Fiscal Year: 2005..The requested instrument offers the flexibility of a multi-user microscope that will be the "work horse" for many laboratories...
- TLI IN RENAL TRANSPLANTATIONSamuel Strober; Fiscal Year: 1990..research program will complete the MLR and CML assays of 30 cadaveric renal transplant recipients given TLI and horse or rabbit ATG, and who have good graft function while receiving only low dose prednisone...
- Targeted Delivery of siRNA for Intravenous RNAiRUBEN BOADO; Fiscal Year: 2009..The TfRMAb acts as a molecular Trojan horse, to ferry the siRNA across any target cell membrane that expresses the TfR...
- IRON DEPOSITION AND MOBILIZATION IN FERRITINNORMAN CHASTEEN; Fiscal Year: 2001..through a combination of EPR, ENDOR, ESEEM and Mossbauer spectroscopy, electrochemistry and kinetic studies of horse and sheep spleen ferritins as well as recombinant H and L human liver ferritins and site-directed mutants thereof...
- HUMAN GRANULOCYTIC EHRLICHIOSIS: NORTH CENTRAL U.S.Russell Johnson; Fiscal Year: 2005..The agent of HGE is closely related to or identical to the horse pathogen Ehrlichia equi and is transmitted by Ixodes scapularis, the same tick that transmits the agents of Lyme ..
- Cancer Targeting with Multi-Responsive Core/Shell MicrogelsLOUIS LYON; Fiscal Year: 2007..Such "trojan horse" type delivery approaches may be particularly effective when faced with tumors displaying multi-drug resistance ..
- BIOCONJUGATE DERIVATIVES OF COENZYMES B-12CHARLES GRISSOM; Fiscal Year: 2000..Our results in vitro show this "Trojan Horse" strategy for targeted drug delivery to be a very effective method to increase the therapeutic index of existing ..
- SIDEROPHORES, ANALOGS AND BIOCONJUGATESMarvin Miller; Fiscal Year: 1999..The siderophore-based "Trojan Horse" drug conjugates also have the potential to alter normal modes of assimilation and renew effectiveness of previous ..
- GONADOTROPINSHarold Papkoff; Fiscal Year: 1990..Techniques of protein chemistry are used to isolate and characterize highly purified equine and related species of luteinizing hormone, follicle stimulating hormone and chorionic gonadotropin...
- Christine A Hrycyna; Fiscal Year: 2014..To this end, we propose the use of a new class of agents - Trojan Horse dimers of known ART to evade P-gp at the BBB and deliver antiretroviral therapies to the brain...
- STRUCTURE & FUNCTION OF LIVER ALCOHOL DEHYDROGENASESWILLIAM BOSRON; Fiscal Year: 1992..was crystallized and its X-ray structure (the first of a human alcohol dehydrogenase) reveals differences from the horse liver enzyme in the coenzyme binding site, which explains the tighter binding of coenzyme to beta1/beta1 versus ..
- STRUCTURE/FUNCTION OF LIVER ALCOHOL DEHYDROGENASESWILLIAM BOSRON; Fiscal Year: 2001..was crystallized and its X-ray structure (the first of a human alcohol dehydrogenase) reveals differences from the horse liver enzyme in the coenzyme binding site, which explains the tighter binding of coenzyme to beta1/beta1 versus ..
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