equine

Summary

Alias: horse, domestic horse, Equus caballus, Equus ferus caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, Equus caballus Linnaeus, 1758

Top Publications

  1. doi Evaluation of MUC5AC expression and upregulation in airway epithelial cells of horses
    Karen L Oslund
    Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine and Center for Comparative Respiratory Biology and Medicine, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Vet Res 71:690-6. 2010
  2. ncbi cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamily
    C Gregoire
    Unite d Immuno Allergie, Departement de Physiopathologie, Institut Pasteur, 28 rue du Dr Roux, 75024 Paris Cedex 15, France
    J Biol Chem 271:32951-9. 1996
  3. pmc Effects of nutritional cues on the duration of the winter anovulatory phase and on associated hormone levels in adult female Welsh pony horses (Equus caballus)
    Juan Salazar-Ortiz
    INRA, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
    Reprod Biol Endocrinol 9:130. 2011
  4. ncbi Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse
    Robert C Tryon
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 9516, USA
    Genomics 90:93-102. 2007
  5. ncbi Linkage of hyperkalaemic periodic paralysis in quarter horses to the horse adult skeletal muscle sodium channel gene
    J A Rudolph
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261
    Anim Genet 23:241-50. 1992
  6. ncbi The complete mitochondrial DNA sequence of the horse, Equus caballus: extensive heteroplasmy of the control region
    X Xu
    Division of Evolutionary Molecular Systematics, Lund, Sweden
    Gene 148:357-62. 1994
  7. ncbi Fibronectin mRNA splice variant in articular cartilage lacks bases encoding the V, III-15, and I-10 protein segments
    J N MacLeod
    Department of Physiology, James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 271:18954-60. 1996
  8. ncbi A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated with the chestnut coat color in horses
    L Marklund
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Science, Uppsala, Sweden
    Mamm Genome 7:895-9. 1996
  9. ncbi Endothelin receptor B polymorphism associated with lethal white foal syndrome in horses
    E M Santschi
    Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
    Mamm Genome 9:306-9. 1998
  10. ncbi A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndrome (LWFS); a horse variant of Hirschsprung disease
    G C Yang
    Department of Surgical Research, Royal Alexandra Hospital for Children, Westmead, NSW 2145, Australia
    Hum Mol Genet 7:1047-52. 1998

Patents

  1. ALBUMIN INSULIN FUSION PROTEIN
  2. Composition and kit for detecting a laminitis in a subject, method for detecting a laminitis in a subject and method for screening a therapeutic agent for a laminitis
  3. Composition and kit for detecting a laminitis in a subject, method for detecting a laminitis in a subject and method for screening a therapeutic agent for a laminitis
  4. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
  5. METHODS OF USING ZSCAN4 FOR REJUVINATING HUMAN CELLS
  6. THYMIC STROMAL LYMPHOPOIETIN FRAGMENTS AND USES THEREOF
  7. COMPLEX CHROMOSOME ENGINEERING FOR PRODUCTION OF HUMAN ANTIBODIES IN TRANSGENIC ANIMALS
  8. Pharmaceutical Composition for Treatment and Prevention of Cancers
  9. METHODS OF USING ZSCAN4 FOR REJUVENATING HUMAN CELLS
  10. Genetically modified filamentous fungus and method of producing multimer having internal cavity using the same

Detail Information

Publications228 found, 100 shown here

  1. doi Evaluation of MUC5AC expression and upregulation in airway epithelial cells of horses
    Karen L Oslund
    Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine and Center for Comparative Respiratory Biology and Medicine, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Vet Res 71:690-6. 2010
    To isolate and culture primary equine airway epithelial cells in vitro and elucidate the major cytokines involved in expression of the gel-forming mucin gene MUC5AC in horses.
  2. ncbi cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamily
    C Gregoire
    Unite d Immuno Allergie, Departement de Physiopathologie, Institut Pasteur, 28 rue du Dr Roux, 75024 Paris Cedex 15, France
    J Biol Chem 271:32951-9. 1996
    The gene encoding the major horse allergen, designated Equus caballus allergen 1 (Equ c1), was cloned from total cDNA of sublingual salivary glands by reverse transcription-polymerase chain reaction using synthetic degenerate ..
  3. pmc Effects of nutritional cues on the duration of the winter anovulatory phase and on associated hormone levels in adult female Welsh pony horses (Equus caballus)
    Juan Salazar-Ortiz
    INRA, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
    Reprod Biol Endocrinol 9:130. 2011
    ..Mares have an annual reproductive rhythm, with a phase of inactivity in midwinter. The aim of this study was to determine the impact of food restriction on physiological and metabolic hallmarks of this rhythm...
  4. ncbi Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse
    Robert C Tryon
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 9516, USA
    Genomics 90:93-102. 2007
    Hereditary equine regional dermal asthenia (HERDA), a degenerative skin disease that affects the Quarter Horse breed, was localized to ECA1 by homozygosity mapping...
  5. ncbi Linkage of hyperkalaemic periodic paralysis in quarter horses to the horse adult skeletal muscle sodium channel gene
    J A Rudolph
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261
    Anim Genet 23:241-50. 1992
    ..A large Quarter horse pedigree segregating dominant HYPP was studied to determine if mutations of the sodium channel gene are similarly ..
  6. ncbi The complete mitochondrial DNA sequence of the horse, Equus caballus: extensive heteroplasmy of the control region
    X Xu
    Division of Evolutionary Molecular Systematics, Lund, Sweden
    Gene 148:357-62. 1994
    The sequence of the mitochondrial (mt) DNA of the horse (Equus caballus) was determined. The length of the sequence presented is 16,660 bp...
  7. ncbi Fibronectin mRNA splice variant in articular cartilage lacks bases encoding the V, III-15, and I-10 protein segments
    J N MacLeod
    Department of Physiology, James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 271:18954-60. 1996
    ..This new splice variant, which we designate (V+C)-, represents the majority of fibronectin transcripts in equine, canine, and rabbit articular cartilage but is absent in the liver...
  8. ncbi A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated with the chestnut coat color in horses
    L Marklund
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Science, Uppsala, Sweden
    Mamm Genome 7:895-9. 1996
    ..The polymorphism can be detected with a simple PCR-RFLP test, since the mutation creates a TaqI restriction site in the chestnut allele...
  9. ncbi Endothelin receptor B polymorphism associated with lethal white foal syndrome in horses
    E M Santschi
    Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
    Mamm Genome 9:306-9. 1998
    ..In this report we identify a polymorphism in the equine EDNRB gene closely associated with OLWS...
  10. ncbi A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndrome (LWFS); a horse variant of Hirschsprung disease
    G C Yang
    Department of Surgical Research, Royal Alexandra Hospital for Children, Westmead, NSW 2145, Australia
    Hum Mol Genet 7:1047-52. 1998
    ..First, we identified a full-length cDNA for horse EDNRB . This cDNA fragment contained a 1329 bp open reading frame which encoded 443 amino acid residues...
  11. ncbi Close association between sequence polymorphism in the KIT gene and the roan coat color in horses
    S Marklund
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, S 751 24 Uppsala, Sweden
    Mamm Genome 10:283-8. 1999
    ..Rn has previously been mapped to equine linkage group (LG) II...
  12. ncbi Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes
    M B Lascombe
    Unité de Biochimie Structurale CNRS URA 2185, Unite d Immuno Allergie, 25 et 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Biol Chem 275:21572-7. 2000
    The three-dimensional structure of the major horse allergen Equ c 1 has been determined at 2.3 A resolution by x-ray crystallography. Equ c 1 displays the typical fold of lipocalins, a beta-barrel flanked by a C-terminal alpha-helix...
  13. ncbi Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus)
    S Rieder
    Laboratoire de Génétique Biochimique et de Cytogénétique, Département de Génétique Animale, INRA Centre de Recherche de Jouy, 78352 Jouy en Josas Cedex, France
    Mamm Genome 12:450-5. 2001
    ..Our panel represented 22 different horse breeds, including 11 different coat colors of Equus caballus. The comparison of a 1721-bp genomic fragment of MC1R among the 11 coat color phenotypes revealed no sequence ..
  14. ncbi Exon skipping in the KIT gene causes a Sabino spotting pattern in horses
    Samantha A Brooks
    Department of Veterinary Science, 108 Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky 40546 0099, USA
    Mamm Genome 16:893-902. 2005
    Sabino (SB) is a white spotting pattern in the horse characterized by white patches on the face, lower legs, or belly, and interspersed white hairs on the midsection...
  15. ncbi Plasma leptin, ghrelin and adiponectin concentrations in young fit racehorses versus mature unfit standardbreds
    Mary E Gordon
    Rutgers, The State University of New Jersey, Equine Science Center, Department of Animal Sciences, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    Vet J 173:91-100. 2007
    ....
  16. ncbi Secretory proteins as potential semiochemical carriers in the horse
    Barbara D'Innocenzo
    Dipartimento di Chimica e Biotecnologie Agrarie, Universita di Pisa, 56124 Pisa, Italy
    Biochemistry 45:13418-28. 2006
    Two soluble proteins were isolated as major secretory products of horse sweat and of the parotid gland and characterized for structural and functional properties...
  17. pmc Allelic heterogeneity at the equine KIT locus in dominant white (W) horses
    Bianca Haase
    Institute of Genetics, Vetsuisse Faculty, University of Berne, Berne, Switzerland
    PLoS Genet 3:e195. 2007
    ..We determined the sequence and genomic organization of the approximately 82 kb equine KIT gene...
  18. doi A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses
    S A Brooks
    Department of Veterinary Science, University of Kentucky, Lexington, KY, USA
    Cytogenet Genome Res 119:225-30. 2007
    ..Here, we report TO associated with a large paracentric chromosome inversion on horse chromosome 3...
  19. doi A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse
    Gerli Rosengren Pielberg
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
    Nat Genet 40:1004-9. 2008
    ..The Gray horse provides a notable example of how humans have cherry-picked mutations with favorable phenotypic effects in ..
  20. pmc Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus)
    Rebecca R Bellone
    Department of Biology, University of Tampa, Tampa, FL 33606, USA
    Genetics 179:1861-70. 2008
    ..Decreased expression of TRPM1 in the eye and the skin may alter bipolar cell signaling as well as melanocyte function, thus causing both CSNB and LP in horses...
  21. doi Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver
    H K DiMaio Knych
    K L Maddy Equine Analytical Chemistry Laboratory, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, West Health Science Drive, Davis, CA 95616, USA
    Biochem Pharmacol 76:904-11. 2008
    ..In the horse, the presence of a member of the CYP2D family has been suggested from studies with equine liver microsomes, however its presence has not been definitively proven...
  22. pmc Equine Multiple Congenital Ocular Anomalies maps to a 4.9 megabase interval on horse chromosome 6
    Lisa S Andersson
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    BMC Genet 9:88. 2008
    b>Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome consists of a diverse set of abnormalities predominantly localized to the frontal part of the eye...
  23. doi INHBA-associated markers as candidates for stallion fertility
    K Giesecke
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Germany
    Reprod Domest Anim 45:342-7. 2010
    ..This is the first report on INHBA as an associated candidate gene with the LSM of stallions and the paternal and embryonic component of BVs for the pregnancy rate per oestrus...
  24. doi Evaluation of SPATA1-associated markers for stallion fertility
    K Giesecke
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, 30559 Hannover, Germany
    Anim Genet 40:359-65. 2009
    ..fertility is an economically important trait because the use of artificial insemination is increasing in the horse industry and superior sires are used more intensely...
  25. doi Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization
    H K DiMaio Knych
    K L Maddy Equine Analytical Chemistry Laboratory, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, West Health Science Drive, Davis, CA 95616, USA
    Arch Biochem Biophys 485:49-55. 2009
    ..Accordingly, a cytochrome P450 monooxygenase in the 2C family was cloned from an equine liver, sequenced and expressed in a baculovirus expression system...
  26. pmc Latherin: a surfactant protein of horse sweat and saliva
    Rhona E McDonald
    Ecology and Evolutionary Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 4:e5726. 2009
    ..latherin, determined from cDNA analysis, is highly conserved across four geographically dispersed equid species (horse, zebra, onager, ass), and is similar to a family of proteins only found previously in the oral cavity and ..
  27. doi Evaluation of prolactin receptor (PRLR) as candidate gene for male fertility in Hanoverian warmblood horses
    K Giesecke
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany
    Reprod Domest Anim 45:e124-30. 2010
    ..Screening the equine PRLR gene for polymorphisms in Hanoverian stallions revealed two single nucleotide polymorphisms (SNPs)...
  28. pmc Genome sequence, comparative analysis, and population genetics of the domestic horse
    C M Wade
    Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA
    Science 326:865-7. 2009
    We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication...
  29. pmc Protein collective motions coupled to ligand migration in myoglobin
    Yasutaka Nishihara
    Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto Japan
    Biophys J 98:1649-57. 2010
    ....
  30. pmc Whole-genome SNP association in the horse: identification of a deletion in myosin Va responsible for Lavender Foal Syndrome
    Samantha A Brooks
    Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 6:e1000909. 2010
    ..LFS has been primarily diagnosed in a subgroup of the Arabian breed, the Egyptian Arabian horse. The condition is characterized by multiple neurological abnormalities and a dilute coat color...
  31. doi Localization of insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR) in equine testes
    M J Yoon
    Department of Animal Science, University of California, Davis, CA, USA
    Reprod Domest Anim 46:221-8. 2011
    ..Immunolabelling of IGF-I and IGF-IR was not observed in Sertoli cells. In conclusion, IGF-I is localized in equine spermatogenic and Leydig cells, and IGF-IR is present in spermatogonia, spermatocytes and Leydig cells, suggesting ..
  32. doi Molecular cloning, expression, and initial characterization of members of the CYP3A family in horses
    Heather K DiMaio Knych
    California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California Davis, West Health Science Drive, Davis, CA 95616, USA
    Drug Metab Dispos 38:1820-7. 2010
    The use of performance-enhancing drugs in the horse racing industry combined with the need for more rational approaches in the use of therapeutic agents in equids necessitates additional studies on the spectrum, content, and catalytic ..
  33. pmc A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses
    Emmeline W Hill
    Animal Genomics Laboratory, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    BMC Genomics 11:552. 2010
    ..It is widely recognized that inherited variation in physical and physiological characteristics is responsible for variation in individual aptitude for race distance, and that muscle phenotypes in particular are important...
  34. doi Comparative human-horse sequence analysis of the CYP3A subfamily gene cluster
    A Schmitz
    Division Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland
    Anim Genet 41:72-9. 2010
    ..We report here the genomic organization of the equine CYP3A gene cluster as well as a comparative analysis with the human CYP3A gene cluster...
  35. doi Increased cartilage oligomeric matrix protein concentrations in equine digital flexor tendon sheath synovial fluid predicts intrathecal tendon damage
    Matthew R W Smith
    Royal Veterinary College, Equine Referral Hospital, North Mymms, UK
    Vet Surg 40:54-8. 2011
    ..To evaluate digital flexor tendon sheath (DFTS) synovial fluid cartilage oligomeric matrix protein (COMP) concentrations as a molecular marker for intrathecal pathology...
  36. pmc Functional expression of the extracellular calcium sensing receptor (CaSR) in equine umbilical cord matrix size-sieved stem cells
    Nicola Antonio Martino
    Department of Animal Production, Faculty of Biotechnological Sciences, University of Bari, Valenzano, Bari, Italy
    PLoS ONE 6:e17714. 2011
    ..and the calcimimetic NPS R-467, a known calcium-sensing receptor (CaSR) agonist, on growth/proliferation of two equine size-sieved umbilical cord matrix mesenchymal stem cell (eUCM-MSC) lines...
  37. ncbi Tissue-specific expression of the calcium transporter genes TRPV5, TRPV6, NCX1, and PMCA1b in the duodenum, kidney and heart of Equus caballus
    Inho Hwang
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361 763, Republic of Korea
    J Vet Med Sci 73:1437-44. 2011
    ..mRNA and protein expression of these calcium transporter genes in the duodenum, kidney and heart of the horse (Equus caballus) was examined using reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis...
  38. pmc Identification of a mutation associated with fatal Foal Immunodeficiency Syndrome in the Fell and Dales pony
    Laura Y Fox-Clipsham
    Animal Health Trust, Newmarket, UK
    PLoS Genet 7:e1002133. 2011
    ..Having identified the associated gene, we are now able to eradicate FIS from equine populations by informed selective breeding.
  39. doi Latherin and other biocompatible surfactant proteins
    Malcolm W Kennedy
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow G12 8QQ, UK
    Biochem Soc Trans 39:1017-22. 2011
    ..It may consequently have a dual role in horse sweat in both evaporative cooling and controlling microbial growth in the pelt that would otherwise be resourced ..
  40. doi Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horses
    Elisabeth Sundström
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Pigment Cell Melanoma Res 25:28-36. 2012
    ..These results provide strong support for the causative nature of the duplication and constitute an explanation for the melanocyte-specific effects of the Grey allele...
  41. doi Congenital stationary night blindness is associated with the leopard complex in the Miniature Horse
    Lynne S Sandmeyer
    Department of Small Animal Clinical Sciences, University of Saskatchewan, Quill Lake, Saskatchewan, Canada
    Vet Ophthalmol 15:18-22. 2012
    To determine if congenital stationary night blindness (CSNB) exists in the Miniature Horse in association with leopard complex spotting patterns (LP), and to investigate if CSNB in the Miniature Horse is associated with three single ..
  42. pmc Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses
    Regula Hauswirth
    Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland
    PLoS Genet 8:e1002653. 2012
    ..Some, but not all, splashed white horses are deaf. We analyzed a Quarter Horse family segregating for the splashed white coat color...
  43. pmc Mutation in cyclophilin B that causes hyperelastosis cutis in American Quarter Horse does not affect peptidylprolyl cis-trans isomerase activity but shows altered cyclophilin B-protein interactions and affects collagen folding
    Yoshihiro Ishikawa
    Research Department, Shriners Hospital for Children, Portland, Oregon 97239, USA
    J Biol Chem 287:22253-65. 2012
    ..B found in the American Quarter Horse leads to autosomal recessive hyperelastosis cutis, also known as hereditary equine regional dermal asthenia...
  44. doi Equine cytochrome P450 2B6--genomic identification, expression and functional characterization with ketamine
    L M Peters
    Division Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University Bern, Laenggassstr 124, 3012 Bern, Switzerland
    Toxicol Appl Pharmacol 266:101-8. 2013
    ..CYPs have been thoroughly examined in humans and laboratory animals, but little is known about equine CYPs. The characterization of equine CYPs is essential for a better understanding of drug metabolism in horses...
  45. pmc Genome-wide association study implicates testis-sperm specific FKBP6 as a susceptibility locus for impaired acrosome reaction in stallions
    Terje Raudsepp
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, USA
    PLoS Genet 8:e1003139. 2012
    ..Here we conducted Equine SNP50 Beadchip genotyping and GWAS using 7 IAR-affected and 37 control Thoroughbred stallions...
  46. doi Stage-dependent DAZL localization in stallion germ cells
    H J Jung
    Department of Animal and Biotechnology Science, College of Animal Science, Kyungpook National University, Sangju 742 711, Republic of Korea
    Anim Reprod Sci 147:32-8. 2014
    ..We conclude that DAZL can be used as a marker of pre-meiotic germ cells in stallions...
  47. pmc Post-mortem stability of RNA in skeletal muscle and adipose tissue and the tissue-specific expression of myostatin, perilipin and associated factors in the horse
    Philippa K Morrison
    University of Liverpool, Department of Obesity and Endocrinology, Faculty of Health and Life Sciences, Leahurst Campus, Neston, Wirral, United Kingdom
    PLoS ONE 9:e100810. 2014
    Obesity, a major concern for equine welfare, is highly prevalent in the leisure horse population. Skeletal-muscle and adipose tissues are important determinants of maintenance energy requirements...
  48. doi Molecular cloning and characterization of phospholipase C zeta in equine sperm and testis reveals species-specific differences in expression of catalytically active protein
    S J Bedford-Guaus
    Departments of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Biol Reprod 85:78-88. 2011
    ..of this research were to clone and characterize the intracellular Ca(2+)-releasing activity and expression of equine PLCZ in sperm and testis...
  49. ncbi Nucleotide sequence of a cDNA clone of the horse (Equus caballus) DRA gene
    D Albright
    Department of Veterinary Sciences, University of Kentucky, Lexington 40536 0084
    Immunogenetics 34:136-8. 1991
  50. ncbi X-ray and primary structure of horse serum albumin (Equus caballus) at 0.27-nm resolution
    J X Ho
    NASA, Marshall Space Flight Center, Huntsville, AL 35812
    Eur J Biochem 215:205-12. 1993
    The amino-acid sequence and three-dimensional structure of equine serum albumin have been determined. The amino-acid sequence was deduced from cDNA isolated from equine liver...
  51. ncbi A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation
    E K Shin
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Immunol 158:3565-9. 1997
    The equine SCID defect is more severe than its murine counterpart in that SCID foals are incapable of forming either coding or signal joints, whereas SCID mice manifest normal signal joint formation...
  52. ncbi Biochemical characterization and surfactant properties of horse allergens
    H Goubran Botros
    Unite d Immuno Allergie, Institut Pasteur, Paris France
    Eur J Biochem 268:3126-36. 2001
    A new allergen from horse dander, Equ c 5 has been purified. Its biochemical and biophysical properties have been characterized and compared with those of Equ c 1, Equ c 2 and Equ c 4...
  53. ncbi Structure of equine 2'-5'oligoadenylate synthetase (OAS) gene family and FISH mapping of OAS genes to ECA8p15-->p14 and BTA17q24-->q25
    A A Perelygin
    Biology Department, Georgia State University, Atlanta, GA 30302 4010, USA
    Cytogenet Genome Res 111:51-6. 2005
    ..In this study, the structures of four equine OAS genes were determined using DNA sequences derived from fifteen cDNA and four BAC clones...
  54. ncbi Genomic characterization of MHC class I genes of the horse
    Rebecca L Tallmadge
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Immunogenetics 57:763-74. 2005
    The availability of a contig of bacterial artificial chromosome (BAC) clones spanning the equine major histocompatibility complex (MHC) made possible a detailed analysis of horse MHC class I genes...
  55. ncbi Assignment of the Equus caballus interleukin 8 gene (IL8) to chromosome 3q14.2-->q14.3 by in situ hybridization
    S G Nergadze
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Cytogenet Genome Res 112:341B. 2006
  56. ncbi The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla
    Andrey A Perelygin
    Biology Department, Georgia State University, P O Box 4010, Atlanta, GA 30302 4010, USA
    J Mol Evol 63:562-76. 2006
    ..pig, and dog OAS genes were amplified, sequenced and compared with each other and with those in the human, mouse, horse, and chicken genomes...
  57. pmc A missense mutation in PMEL17 is associated with the Silver coat color in the horse
    Emma Brunberg
    Dept of Medical Biochemistry and Microbiology, Uppsala University, SE 751 24 Uppsala, Sweden
    BMC Genet 7:46. 2006
    The Silver coat color, also called Silver dapple, in the horse is characterized by dilution of the black pigment in the hair. This phenotype shows an autosomal dominant inheritance...
  58. ncbi Analysis of peripheral blood mononuclear cells gene expression in endurance horses by cDNA-AFLP technique
    Katia Cappelli
    Centro di Studio del Cavallo Sportivo, Facolta di Medicina Veterinaria, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy
    Res Vet Sci 82:335-43. 2007
    ..The mRNAs sequences obtained were included in the GenBank database as Equus caballus interleukin 8 (IL8), E. caballus retinoblastoma binding protein 6 mRNA (RBBP6), E...
  59. ncbi Clenbuterol affects the expression of messenger RNA for interleukin 10 in peripheral leukocytes from horses challenged intrabronchially with lipopolysaccharides
    R van den Hoven
    Department of Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases, Institute of Medical Chemistry, Veterinary University of Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Vet Res Commun 30:921-8. 2006
    ..Thus the results of this study indicated that clenbuterol can modulate the expression of IL-10 mRNA in peripheral white blood cells in those horses with small airway diseases that have been exposed to LPS...
  60. pmc Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes
    Jonathan J Rios
    Department of Animal Science, Texas A and M University, 2471 TAMU, College Station, Texas 77843, USA
    BMC Genomics 8:313. 2007
    ..No polymorphisms have yet been identified in either the equine OAS1 or RNASEL genes for use in similar case-control studies.
  61. pmc Exercise-induced up-regulation of MMP-1 and IL-8 genes in endurance horses
    Katia Cappelli
    Pathology, Diagnostic and Veterinary Clinic Department, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy
    BMC Physiol 9:12. 2009
    The stress response is a critical factor in the training of equine athletes; it is important for performance and for protection of the animal against physio-pathological disorders...
  62. doi Fine-mapping and mutation analysis of TRPM1: a candidate gene for leopard complex (LP) spotting and congenital stationary night blindness in horses
    Rebecca R Bellone
    Department of Biology, University of Tampa, Tampa, FL 33611, USA
    Brief Funct Genomics 9:193-207. 2010
    ..Further, this work has identified several potential regulatory elements of the TRPM1 gene that should be investigated further in this and other species...
  63. doi A preliminary study on the effect of wounding on transforming growth factor-β1 and cartilage oligomeric matrix protein concentrations in the skin of horses
    Andrew J Dart
    Faculty of Veterinary Science, University of Sydney, Sydney, Australia
    Vet Surg 40:59-65. 2011
    ..To evaluate whether wound type or site influence the production of cartilage oligomeric matrix protein (COMP) and transforming growth factor β1 (TGF-β1), and determine if there is a correlation between TGF-β1and COMP during healing...
  64. doi Decreased expression of p63, a regulator of epidermal stem cells, in the chronic laminitic equine hoof
    R A Carter
    Laminitis Institute, Department of Clinical Studies New Bolton Center, University of Pennsylvania School of Veterinary Medicine, PA, USA
    Equine Vet J 43:543-51. 2011
    Abnormal epidermal stem cell regulation may contribute to the pathogenesis of equine chronic laminitis.
  65. pmc Multiple congenital ocular anomalies in Icelandic horses
    Lisa S Andersson
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, SE 751 24 Uppsala, Sweden
    BMC Vet Res 7:21. 2011
    ..ocular defects are caused by a recent mutation that is restricted to horses that are related to the Rocky Mountain Horse breed...
  66. pmc Comparative analysis of vertebrate EIF2AK2 (PKR) genes and assignment of the equine gene to ECA15q24-q25 and the bovine gene to BTA11q12-q15
    Andrey A Perelygin
    Biology Department, Georgia State University, Atlanta, 30302, USA
    Genet Sel Evol 38:551-63. 2006
    The structures of the canine, rabbit, bovine and equine EIF2AK2 genes were determined. Each of these genes has a 5' non-coding exon as well as 15 coding exons...
  67. ncbi Comparative mapping of 18 equine type I genes assigned by somatic cell hybrid analysis
    A R Caetano
    University of California Davis, Veterinary Genetics Laboratory, Davis, California 95616 8744, USA
    Mamm Genome 10:271-6. 1999
    ..from consensus sequences highly conserved in mammalian species were used to amplify markers for synteny mapping 18 equine type I genes. These markers were used to screen a horse-mouse somatic cell hybrid panel (UCDavis SCH)...
  68. doi Probable reason why small strongyle EPG counts are returning "early" after ivermectin treatment of horses on a farm in Central Kentucky
    E T Lyons
    Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY, 40546 0099, USA
    Parasitol Res 104:569-74. 2009
    ..from posttreatment (PT) worm count data, the current activity of ivermectin against small strongyles in a horse herd...
  69. ncbi The role of neutrophil chemotactic cytokines in the pathogenesis of equine chronic obstructive pulmonary disease (COPD)
    M Franchini
    Institute of Veterinary Physiology, University of Zurich, Switzerland
    Vet Immunol Immunopathol 66:53-65. 1998
    ..1973. Chronic pulmonary disease in the horse, Equine Vet. J. 5, 26-33; Winder, N.C., Grünig, G., Hermann, M., Howald, B., von Fellenberg, R., 1989...
  70. ncbi Epidemiology of Trichinella infection in the horse: the risk from animal product feeding practices
    K D Murrell
    WHO FAO Collaborating Centre for Parasitic Zoonosis, Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University, 3 Ridebanevej, DK 1870 Frederiksberg Copenhagen, Denmark
    Vet Parasitol 123:223-33. 2004
    A discovery in 2002 of a Trichinella spiralis-infected horse in Serbia offered an opportunity to conduct needed epidemiological studies on how horses, considered herbivores, acquire a meat-borne parasite...
  71. doi Anthelmintic resistance in cyathostomins of brood horses in Ukraine and influence of anthelmintic treatments on strongylid community structure
    Tetyana A Kuzmina
    Department of Parasitology, I I Schmalhausen Institute of Zoology NAS of Ukraine, vul B Khmelnitskogo 15, Kyiv 01601, Ukraine
    Vet Parasitol 154:277-88. 2008
    In 2004-2006, 322 brood horses from 11 horse farms were examined using the faecal egg count reduction test (FECRT) to determine the presence and distribution of anthelmintic resistance in strongylids in Ukraine...
  72. pmc Association of deficiency in antibody response to vaccine and heterogeneity of Ehrlichia risticii strains with Potomac horse fever vaccine failure in horses
    S K Dutta
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park 20742, USA
    J Clin Microbiol 36:506-12. 1998
    Ehrlichia risticii is the causative agent of Potomac horse fever (PHF), which continues to be an important disease of horses. Commercial inactivated whole-cell vaccines are regularly used for immunization of horses against the disease...
  73. doi Facial hair whorls (trichoglyphs) and the incidence of motor laterality in the horse
    Jack Murphy
    Department of Life Sciences, University of Limerick, Limerick, Ireland
    Behav Processes 79:7-12. 2008
    ..Motor laterality in the horse affects locomotion and subsequently equine performance during training and may have inherent safety implications for equitation...
  74. doi Long-term memory for categories and concepts in horses (Equus caballus)
    Evelyn B Hanggi
    Equine Research Foundation, Aptos, CA 95001, USA
    Anim Cogn 12:451-62. 2009
    Three horses (Equus caballus) with a history of performing cognitive tasks including discrimination learning, categorization, and concept use were tested to evaluate their long-term memory (LTM) in three experiments...
  75. doi Visual laterality in the domestic horse (Equus caballus) interacting with humans
    Kate Farmer
    Centre for Social Learning and Cognitive Evolution, School of Psychology, University of St Andrews, St Andrews, Fife, Scotland, UK
    Anim Cogn 13:229-38. 2010
    ..As such lateralisation could provide important clues regarding the horse's cognitive processes, we investigated whether horses also show laterality in association with people...
  76. pmc Validation of models for analysis of ranks in horse breeding evaluation
    Anne Ricard
    INRA, UMR 1313, 78352 Jouy en Josas, France
    Genet Sel Evol 42:3. 2010
    ..The simulations involved 1000 horses with 10 to 50 performances per horse and 4 to 20 horses per event with unstructured and structured competitions.
  77. doi Horse domestication and conservation genetics of Przewalski's horse inferred from sex chromosomal and autosomal sequences
    Allison N Lau
    Department of Biology, The Pennsylvania State University, University Park, USA
    Mol Biol Evol 26:199-208. 2009
    ..fertile offspring, there is continued disagreement about the genetic relationship of the domestic horse (Equus caballus) to its endangered wild relative, Przewalski's horse (Equus przewalskii)...
  78. pmc Characteristics of equine summer eczema with emphasis on differences between Finnhorses and Icelandic horses in a 11-year study
    Raija E Hallamaa
    Veterinary Clinic, Pisteenkaari 4, 03100 Nummela, Finland
    Acta Vet Scand 51:29. 2009
    ..b>Equine summer eczema seems to be aggravated by various combinations of environmental factors.
  79. ncbi Crib-biting in US horses: breed predispositions and owner perceptions of aetiology
    J D Albright
    Departments of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Equine Vet J 41:455-8. 2009
    Crib-biting is an equine stereotype that may result in diseases such as colic. Certain breeds and management factors have been associated.
  80. ncbi Effects of a calm companion on fear reactions in naive test horses
    J W Christensen
    Department of Animal Health, Welfare and Nutrition, Faculty of Agricultural Sciences, University of Aarhus, Tjele, Denmark
    Equine Vet J 40:46-50. 2008
    In fear-eliciting situations, horses tend to show flight reactions that can be dangerous for both horse and man. Finding appropriate methods for reducing fearfulness in horses has important practical implications.
  81. ncbi Microbial source tracking by DNA sequence analysis of the Escherichia coli malate dehydrogenase gene
    Kathryn M Ivanetich
    University of California San Francisco, Biomolecular Resource Center and Department of Pharmaceutical Chemistry, Surge 104, 90 Medical Center Way, San Francisco, CA 94143 0541, USA
    J Microbiol Methods 67:507-26. 2006
    ..295 fecal isolates (52 horse, 50 deer, 72 dog, 52 seagull and 69 human isolates) were sequenced and analyzed...
  82. pmc Equine clinical genomics: A clinician's primer
    M M Brosnahan
    Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, New York, USA
    Equine Vet J 42:658-70. 2010
    ..to the rapidly evolving field of clinical genomics with a vision of improving the health and welfare of the domestic horse. For 15 years a consortium of veterinary geneticists and clinicians has worked together under the umbrella of ..
  83. ncbi Effect of sperm cryopreservation and treatment with calcium ionophore or heparin on in vitro fertilization of horse oocytes
    H Alm
    Department of Reproductive Biology, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    Theriogenology 56:817-29. 2001
    Little information is available on methods of sperm capacitation for IVF in the horse. In this study, we summarized results of several independent trials that compared acrosome reaction, hyperactivation and chromatin integrity of fresh ..
  84. ncbi 13C NMR spectroscopic and X-ray crystallographic study of the role played by mitochondrial cytochrome b5 heme propionates in the electrostatic binding to cytochrome c
    M J Rodríguez-Marañón
    Department of Chemistry, Oklahoma State University, Stillwater 74078, USA
    Biochemistry 35:16378-90. 1996
    ..membrane (OM) cytochrome b5 heme propionate groups in the electrostatic binding between OM cytochrome b5 and horse heart cytochrome c was investigated by 13C NMR spectroscopy and X-ray crystallography...
  85. doi Selective inhibition of butyrylcholinesterase in vivo in horses by the feed-through larvacide Equitrol
    Subramanya Karanth
    Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, 264 McElroy Hall, Stillwater, OK 74078, USA
    Regul Toxicol Pharmacol 50:200-5. 2008
    ..g., Equitrol) for fly control around horse stables...
  86. ncbi Use of reverse transcriptase-polymerase chain reaction (RT-PCR) and dot-blot hybridisation for the detection and identification of African horse sickness virus nucleic acids
    S Zientara
    Centre National d Etudes Veterinaires et Alimentaires, Laboratoire Central de Recherches Veterinaires, Maisons Alfort, France
    Arch Virol Suppl 14:317-27. 1998
    A coupled reverse transcriptase-polymerase chain reaction assay (RT-PCR) for the detection of African horse sickness virus (AHSV) dsRNA, has been developed using genome segment 7 as the target template for primers...
  87. ncbi Optical spectroscopy of nicotinoprotein alcohol dehydrogenase from Amycolatopsis methanolica: a comparison with horse liver alcohol dehydrogenase and UDP-galactose epimerase
    S R Piersma
    Department of Microbiology and Enzymology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Biochemistry 37:3068-77. 1998
    ..maxima compared to other NADH-dehydrogenase complexes, but comparable to that observed for NADH bound to horse liver alcohol dehydrogenase...
  88. doi Evaluation of parasiticidal activity of fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate in horse foals with emphasis on ascarids (Parascaris equorum) in field studies on five farms in Central Kentucky in 2007
    E T Lyons
    Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546 0099, USA
    Parasitol Res 103:287-91. 2008
    b>Horse foals on five farms in Central Kentucky were used in field studies in 2007 evaluating activity of paste formulations of four compounds (fenbendazole-FBZ, ivermectin-IVM, oxibendazole-OBZ, and pyrantel pamoate-PRT) against internal ..
  89. ncbi The transmission and geographical spread of African horse sickness and bluetongue viruses
    P S Mellor
    Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, U K
    Ann Trop Med Parasitol 89:1-15. 1995
    African horse sickness virus (AHSV) and bluetongue virus (BTV) are dsRNA viruses within the genus Orbivirus. Both are able to cause non-contagious, infectious arthropod-borne diseases in their respective vertebrate hosts...
  90. ncbi Cross-reactivity of Japanese encephalitis virus-vaccinated horse sera in serodiagnosis of West Nile virus
    Jiro Hirota
    Research Team for Advanced Biologicals, National Institute of Animal Health, National Agriculture and Food Research Organization, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Vet Med Sci 72:369-72. 2010
    ..However, the cross-reactivity level of JEV-vaccinated horse sera in the serodiagnosis of West Nile virus (WNV) has not been clarified...
  91. pmc Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries
    D Prieto
    Departamento de Fisiologia, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 123:1609-20. 1998
    1. Penile small arteries (effective internal lumen diameter of 300 600 microm) were isolated from the horse corpus cavernosum and mounted in microvascular myographs in order to investigate the mechanisms underlying the endothelium-..
  92. ncbi Detection of testosterone, nandrolone and precursors in horse hair
    P Anielski
    Institute of Doping Analysis and Sports Biochemistry, Dresdner Str 12, 01731 Kreischa, Germany
    Anal Bioanal Chem 383:903-8. 2005
    Growing interest among several horse-breeder associations has initiated the development of a screening procedure to test for anabolic agents in hair, which has the advantage over blood and urine specimens of allowing long-term detection...
  93. ncbi Clinical trials of efficacy of praziquantel horse paste 9% against tapeworms and its safety in horses
    J Owen D Slocombe
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ont, Canada N1G 2W1
    Vet Parasitol 144:366-70. 2007
    ..naturally infected with tapeworms was to confirm in clinical trials the efficacy and safety of a praziquantel horse paste 9%. The field trials were conducted in 1997 and 1998 in Canada, France, Germany and New Zealand...
  94. doi Sexual behavior and ejaculate characteristics in Pêga donkeys (Equus asinus) mounting estrous horse mares (Equus caballus)
    I F Canisso
    Equid Breeding Center, Department of Animal Science, Federal University of Vicosa, Vicosa, Minas Gerais, Brazil
    Theriogenology 73:56-63. 2010
    ..of donkey stallions (jacks; Equus asinus) during on-farm semen collection using estrous horse mares (mares; Equus caballus); (ii) compare behavior of young (less experienced) versus older (more experienced) jacks; (iii) determine ..
  95. doi Vitamin D(3) synthesis in the entire skin surface of dairy cows despite hair coverage
    L Hymøller
    Department of Animal Health and Bioscience, Aarhus University, Faculty of Agricultural Sciences, Blichers alle 20, Box 50, DK 8830 Tjele, Denmark
    J Dairy Sci 93:2025-9. 2010
    ..The treatments were horse blanket (cows fitted with horse blankets), udder cover (cows fitted with udder covers, horse blanket+udder cover (..
  96. doi Protective immunization of horses with a recombinant canarypox virus vectored vaccine co-expressing genes encoding the outer capsid proteins of African horse sickness virus
    Alan J Guthrie
    Equine Research Centre, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
    Vaccine 27:4434-8. 2009
    ..with a commercial recombinant canarypox virus vectored vaccine expressing the haemagglutinin genes of two equine influenza H3N8 viruses was seronegative to AHSV and following infection with virulent AHSV-4 developed pyrexia, ..
  97. pmc Heterogeneity of the neuropeptide Y (NPY) contractile and relaxing receptors in horse penile small arteries
    Dolores Prieto
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Br J Pharmacol 143:976-86. 2004
    ..of NPY upon electrical field stimulation (EFS)- and noradrenaline (NA)-elicited contractions were investigated in horse penile small arteries...
  98. ncbi Antigenic profile of African horse sickness virus serotype 4 VP5 and identification of a neutralizing epitope shared with bluetongue virus and epizootic hemorrhagic disease virus
    J L Martinez-Torrecuadrada
    Inmunologia y Genetica Aplicada SA Ingenasa, Hnos Garcia Noblejas 41, Madrid, 28037, Spain
    Virology 257:449-59. 1999
    African horse sickness virus (AHSV) causes a fatal disease in horses. The virus capsid is composed of a double protein layer, the outermost of which is formed by two proteins: VP2 and VP5...
  99. ncbi Folding of horse cytochrome c in the reduced state
    A K Bhuyan
    School of Chemistry, University of Hyderabad, Hyderabad, 500046, India
    J Mol Biol 312:1135-60. 2001
    Equilibrium and kinetic folding studies of horse cytochrome c in the reduced state have been carried out under strictly anaerobic conditions at neutral pH, 10 degrees C, in the entire range of aqueous solubility of guanidinium ..
  100. pmc Purification and characterization of cysteine protease from germinating cotyledons of horse gram
    Rajeswari Jinka
    Center for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
    BMC Biochem 10:28. 2009
    ..To study the mechanism of protein mobilization, undertaken the task of purifying and characterizing proteases, which occur transiently in germinating seeds of horse gram.
  101. doi Ulcerative cystitis associated with phenylbutazone administration in two horses
    Monica Aleman
    William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    J Am Vet Med Assoc 239:499-503. 2011
    A 15-year-old Quarter Horse gelding and a 26-year-old Thoroughbred gelding were evaluated because of hematuria of 4 to 6 days' duration following prolonged oral administration of phenylbutazone.

Research Grants64

  1. Crosslink augmentation to resist snoring and obstructive sleep apnea syndrome
    Thomas P Hedman; Fiscal Year: 2013
    ..a wind tunnel test system will be developed to measure the vibration magnitude and oscillation frequency of horse soft palates;3) the wind tunnel will be used to quantify reduction of vibration in horse soft palates following ..
  2. Epigenetics: A Novel Approach in Primary Immunodeficiencies
    MARIA JULIA BEVILAQUA FELIPPE; Fiscal Year: 2010
    ..The goal of this proposal is to introduce and investigate the mechanism of disease in a natural equine model of CVID, for direct application in diagnostics and management of human patients with primary humoral ..
  3. REGULATION OF MHC GENES IN TROPHOBLAST
    DOUGLAS ANTCZAK; Fiscal Year: 1999
    ..Advantages of the equine model include non- surgical recovery of conceptuses at any stage of development between days 6 and 36 after ..
  4. A novel model for the study of primary immunodeficiency: the equine CVID
    MARIA FLAMINIO; Fiscal Year: 2009
    ..Although these equine patients do not respond to tetanus-toxoid vaccination with specific-immunoglobulin production, they do respond to ..
  5. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2005
    ..mechanisms of granulocytic ehrlichiae, we will use a convenient mouse model and validate results in the horse model that mostly closely simulates human disease. Thus, we propose to: 1...
  6. Development of Medical Countermeasures to Ricin Poisoning
    THOR BORGFORD; Fiscal Year: 2009
    ..During the course of the equine antidote development, novel approaches will be investigated to test and improve the effectiveness of an antibody-..
  7. A MODEL OF BRONCHIAL HYPERREACTIVITY
    N Robinson; Fiscal Year: 1990
    ..Our principal aims are to determine if horse and pony airway smooth muscle receive sympathetic innervation and possesses a nonadrenergic inhibitory nervous ..
  8. Cytotoxic T Lymphocytes in immunity to Rhodococcus equi
    KRISTIN HASEL; Fiscal Year: 2003
    ..The co-sponsors have experience in performing state-of-the-art research involving equine cytotoxic T lymphocytes (CTLs) and pulmonary immunology of Rhodococcus equi, as well as the training of PhD ..
  9. Shonga Ska: Sacred Horse Society Drug Prevention Program
    LESLIE WHITBECK; Fiscal Year: 2006
    ..The proposed program will be based on a blend of equine-assisted therapy techniques and Omaha traditions pertaining to the horse in their culture...
  10. Etiologic studies on EMND: An animal model for ALS
    Hussni Mohammed; Fiscal Year: 2004
    b>Equine motor neuron disease (EMND) is a neurodegenerative disorder of the horse characterized by progressive weakness, fasciculations, muscle wasting, and weight loss...
  11. IRON CHELATOR DELIVERY IN RED BLOOD CELL GHOSTS
    Ralph Green; Fiscal Year: 1980
    ..Using the RBCG as a Trojan Horse for delivery of DF into RE cells, we will measure the rates of iron loss in normal, iron-loaded and ..
  12. Howard E Gendelman; Fiscal Year: 2016
    ..Monthly nanoART injection, to subcellular sites of viral replication is possible We posit that this "Trojan Horse" MP carriage of the drug formulations can facilitate long-lived storage depots, in liver and spleen, resulting in ..
  13. Effects of apoptotic epithelial cell engulfment on mucosal inflammation
    Peter B Ernst; Fiscal Year: 2010
    ..they carry an intracellular infection with Salmonella enterica serovar Typhimurium may act as a microbial "Trojan horse" that transports internalized bacteria into the APC thereby stimulating inflammatory responses...
  14. An Exotendon Prosthesis to Improve Walking for Lower Limb Amputees
    BRIAN GLAISTER; Fiscal Year: 2012
    ..Borrowing from horse anatomy where short muscles interact with long tendons that stretch across multiple joints, exotendons can store ..
  15. Jaymie R Meliker; Fiscal Year: 2014
    ..the late 20th century resulted in increased cadmium in foodstuffs and tobacco, earning it notoriety as "the Trojan horse of the green revolution"...
  16. Marvin J Miller; Fiscal Year: 2016
    ..and virulence can provide new approaches to development of antiTB agents while assessing the underexplored "Trojan Horse" approach. Aim 3. Evaluate all lead compounds using appropriate in vitro and in vivo pre-clinical studies...
  17. Comparative analysis of the 4D encoding of regulatory networks in stem cells
    Seyed Ali Mortazavi; Fiscal Year: 2013
    ..demonstrate the power of these methods, we will apply them to study the differentiation of existing human, mouse, horse and dog stem cells into cardiomyocytes and neurons in order to understand the role, conservation and dynamics of ..
  18. John C Schimenti; Fiscal Year: 2016
    ..Their research concentrates primarily on vertebrate organisms, including mice, zebrafish, dog, horse, and humans, but also represented are C. elegans and Drosophila...
  19. Acquisition of a Q-TOF Mass Spectrometer
    Wei Li; Fiscal Year: 2012
    ..The Bruker Esquire-LC/MS system has been well maintained and is the work horse supporting extensive small-molecular drug discovery and drug delivery programs at UTHSC in the areas of cancer, ..
  20. Jason A Carlyon; Fiscal Year: 2016
    ..A. phagocytophilum converts its host neutrophil into a Trojan horse that facilitates pathogen replication and dissemination...
  21. Metachromatic Leukodystrophy Enzyme Drug Development
    KA WAI HUI; Fiscal Year: 2012
    ..The present work will re-engineer human ASA to enable transport across the BBB using a molecular Trojan horse technology...
  22. Biopsy and Freezing of Later-stage Mouse Blastocysts Using the Dracula Pipette
    Edward E Schmidt; Fiscal Year: 2013
    ..for the first time, dramatic advances in cryopreservation of large hatched embryos such as those of the llama and horse. Now, GeneSearch is scaling down the size of the tool, using new materials for some parts, and improving its ..
  23. The roles of Anaplasma phagocytophilum surface proteins in cellular invasion
    Jason A Carlyon; Fiscal Year: 2012
    ..A. phagocytophilum converts its host neutrophil into a Trojan Horse that facilitates pathogen replication and dissemination...
  24. Flow Cytometry Cell Sorter
    ZUHAIR BALLAS; Fiscal Year: 2009
    ..It serves as a work horse for cloning, isolating cells expressing fluorescent protein markers, multi-color cell sorting of rare cell ..
  25. Characterization of Tau Lymphocyte Modulation in Pregnancy
    LEELA E NORONHA; Fiscal Year: 2010
    ..This project takes advantage of the naturally occurring modulation of maternal immunity in equine pregnancy that offers unique insights into the fetal-maternal immunological relationship in mammals...
  26. Ruben J Boado; Fiscal Year: 2014
    ..The HIRMAb part of the HIRMAb-TNFR fusion protein acts as a molecular Trojan horse to ferry the fused decoy receptor across the BBB via receptor-mediated transport on the endogenous BBB insulin ..
  27. KA WAI HUI; Fiscal Year: 2014
    ..The ASA enzyme is fused to a BBB molecular Trojan horse, which is a genetically engineered peptidomimetic monoclonal antibody (MAb) against an endogenous BBB peptide ..
  28. Enzyme replacement therapy of the brain in Mucopolysaccharidosis Type II
    Zhiqiang Lu; Fiscal Year: 2013
    ..The IDS is genetically fused to a BBB molecular Trojan horse, which is a genetically engineered peptidomimetic monoclonal antibody (MAb) against an endogenous BBB peptide ..
  29. ROBERT P BOWSER; Fiscal Year: 2015
    ..Iron Horse Diagnostics, Inc...
  30. High Resolution MR Imaging of Damaged Myocardium in Patients with Arrhythmia
    Benoit Desjardins; Fiscal Year: 2010
    ..impact on quality of life, as the discharge from an ICD is described as similar to being kicked in the chest by a horse. Radiofrequency ablation under guidance of cardiac electrical mapping, a therapy rapidly growing in importance and ..
  31. MHC suppression as a model for transplant tolerance
    Arnar Geirsson; Fiscal Year: 2007
    ..In veterinary experiments, a zebra ovum implanted in a horse resulted in the birth of a normal zebra, yet there is a species difference...
  32. Nanometer-scale protein patterns for cell culture by laser inactivation
    WILLIAM HEINZ; Fiscal Year: 2009
    ..enabled the significant advances in public health, such as the discovery of the polio vaccine, and are the work horse of modern biomedical sciences...
  33. Manufacturing of Trojan Horse-TNFR Decoy Receptor Fusion Protein
    Ruben J Boado; Fiscal Year: 2012
    ..The HIRMAb part of the HIRMAb-TNFR fusion protein acts as a molecular Trojan horse to ferry the fused decoy receptor across the BBB via receptor-mediated transport on the endogenous BBB insulin ..
  34. OXYGEN RADICAL-ENZYME SCAVENGING IN ONCHOCERCA
    Eric James; Fiscal Year: 1990
    ..GSH-Px) principally in mf but also in adult worms and third stage larvae (L3s) of Onchocerca cervicalis, a common equine parasite in the USA which is very closely related to O. volvulus of man...
  35. Neonatal Phototherapy / Bilirubin Excretion
    DAVID LIGHTNER; Fiscal Year: 2007
    ..5) Design and synthesize bilirnbin fluorophores and MRI-sensitive imaging agents and Trojan Horse vehicles for research and clinical applications involving pigment distribution, hepatic uptake, clearance and drug ..
  36. Borrelia lipoproteins with the cerebral microcirculation
    Diego Cadavid; Fiscal Year: 2007
    ..Pathogens may cross the BBB through paracellular, transcellular, and/or Trojan horse mechanisms...
  37. Ferritin and Iron Nutrition in Health and Disease
    Elizabeth Theil; Fiscal Year: 2005
    ..Legume seeds consumed by humans are rich in iron and ferritin. Soybean seed iron (largely ferritin) and horse spleen ferritin are available iron sources for iron deficient rats...
  38. Development of Therapeutics to Eliminate HIV
    John J Osterhout; Fiscal Year: 2010
    ..which represents a first step toward the attainment of our long term goal, is the development of Trojan horse inhibitors (THIs) that are activated by HIV protease and serve to kill the cells in which the HIV is attempting to ..
  39. Bone marrow monocyte output and virus import into the CNS in acute SIV infection
    Michael McChesney; Fiscal Year: 2009
    ..SIVmac251 infection prevents virus import into the Central Nervous System (CNS) and monocytes'role as `Trojan Horse'for virus brain entry...
  40. Re-Engineering Blood-Borne Erythropoietin for Targeted Delivery
    Ruben J Boado; Fiscal Year: 2011
    ..The HIRMAb part of the HIRMAb-EPO fusion protein acts as a molecular Trojan horse to ferry the fused EPO across the BBB via receptor-mediated transport on the endogenous BBB insulin receptor...
  41. Gallium, a potential new therapeutic for CF airway infections
    Pradeep K Singh; Fiscal Year: 2010
    Here we investigate a novel antimicrobial approach using the metal gallium (Ga) as a "Trojan horse" to disrupt bacterial Fe metabolism...
  42. ELECTRON TRANSFER IN DYNAMIC PROTEIN COMPLEXES
    JAMES ERMAN; Fiscal Year: 2009
    ..very well characterized with crystal structures available for 1:1 complexes of yeast iso-1 cytochrome c/CcP and horse cytochrome c/CcP, as well as for the individual proteins...
  43. OCCUPATIONAL ASTHMA ASOCIATED WITH SEAFOOD PROCESSING
    Thomas Robins; Fiscal Year: 2001
    ..exposure to lobster and saltwater bony fish (pilchard, Cape anchovy, mackerel, light fish, redeye, Cape horse mackerel, lantern fish) and health outcomes expected to be mediated through an immunologic IgE mechanism...
  44. Replacement of Microscopy Core 10-years-old Zeiss LSM-510 with a new LSM-710
    Phong T Tran; Fiscal Year: 2010
    ..John Murray). This microscope has been a work-horse for more than 10 years, has contributed to the research of more than 30 NIH-funded laboratories, and has directly ..
  45. TRANSPORT OF AN E COLI VIRULENCE FACTOR--THE K1 CAPSULE
    Richard Silver; Fiscal Year: 2000
    ..investigator proposes to purify polysialic acid from cells using an immunoaffinity column of specifically purified horse antiserum, and polyclonal anti-KpsT antibody will be used to detect KpsT attached to polysaccharide...
  46. 15TH INTERNATIONAL HERPESVIRUS WORKSHOP
    LEONARD ROSENTHAL; Fiscal Year: 1990
    ..Marek's Disease virus), swine (Pseudorabies virus), and dairy (bovine rhinotracheitis virus) industries and the equine herpesviruses cause significant losses to horse breeders...
  47. PEROXIDASES, CATALASES, AND CYTOCHROME P-450
    ZBIGNIEW KORSZUN; Fiscal Year: 1991
    ..peroxides and ex- hibits catalytic intermediates which are similar in structure and function to catalase and horse radish peroxidase...
  48. CHEMISTRY OF INHIBIN AND RELATED HORMONES
    DARRELL WARD; Fiscal Year: 1990
    ..Our studies will utilize the genomic cosmid libraries we have prepared from pig, human, horse, cow, mouse, and chicken to evaluate the distribution of the inhibin gene(s) in these species...
  49. AUTONOMIC-EPITHELIAL INTERACTIONS IN AIRWAY DISEASE
    Richard Broadstone; Fiscal Year: 1990
    In Phase I of this award I will obtain a Ph.D. in physiology investigating autonomic regulation of horse airways...
  50. 800 MHz Triple Resonance Observe (TXO) Detection CryoProbe
    Gerhard Wagner; Fiscal Year: 2010
    ..cryoplatform and two triple-resonance cryoprobes that are optimized for 1H detection (TCI), which will be the work horse for 3D ad 4D dispersed NOESY experiments, and a 13C/15N detection optimized probe, which will be used for novel ..
  51. GRANULOCYTIC EHRLICHIAS IN TICKS AND TICK CELL CULTURE
    Ulrike Munderloh; Fiscal Year: 2002
    ..Last year, two research groups isolated the etiologic agent from human patients (Goodman et al. 1996) and a horse (Munderloh et al...
  52. Vaccine discovery for Burkholderia via protection screen
    JEFFREY NORDSTROM; Fiscal Year: 2003
    Glanders is a severe disease that has already been used as a bioweapon. It is naturally an equine disease but can be administered by aerosol for efficient human infection...
  53. LASER SCANNING CONFOCAL MICROSCOPE
    Nigel Bunnett; Fiscal Year: 2005
    ..The requested instrument offers the flexibility of a multi-user microscope that will be the "work horse" for many laboratories...
  54. TLI IN RENAL TRANSPLANTATION
    Samuel Strober; Fiscal Year: 1990
    ..research program will complete the MLR and CML assays of 30 cadaveric renal transplant recipients given TLI and horse or rabbit ATG, and who have good graft function while receiving only low dose prednisone...
  55. Targeted Delivery of siRNA for Intravenous RNAi
    RUBEN BOADO; Fiscal Year: 2009
    ..The TfRMAb acts as a molecular Trojan horse, to ferry the siRNA across any target cell membrane that expresses the TfR...
  56. IRON DEPOSITION AND MOBILIZATION IN FERRITIN
    NORMAN CHASTEEN; Fiscal Year: 2001
    ..through a combination of EPR, ENDOR, ESEEM and Mossbauer spectroscopy, electrochemistry and kinetic studies of horse and sheep spleen ferritins as well as recombinant H and L human liver ferritins and site-directed mutants thereof...
  57. HUMAN GRANULOCYTIC EHRLICHIOSIS: NORTH CENTRAL U.S.
    Russell Johnson; Fiscal Year: 2005
    ..The agent of HGE is closely related to or identical to the horse pathogen Ehrlichia equi and is transmitted by Ixodes scapularis, the same tick that transmits the agents of Lyme ..
  58. Cancer Targeting with Multi-Responsive Core/Shell Microgels
    LOUIS LYON; Fiscal Year: 2007
    ..Such "trojan horse" type delivery approaches may be particularly effective when faced with tumors displaying multi-drug resistance ..
  59. BIOCONJUGATE DERIVATIVES OF COENZYMES B-12
    CHARLES GRISSOM; Fiscal Year: 2000
    ..Our results in vitro show this "Trojan Horse" strategy for targeted drug delivery to be a very effective method to increase the therapeutic index of existing ..
  60. SIDEROPHORES, ANALOGS AND BIOCONJUGATES
    Marvin Miller; Fiscal Year: 1999
    ..The siderophore-based "Trojan Horse" drug conjugates also have the potential to alter normal modes of assimilation and renew effectiveness of previous ..
  61. GONADOTROPINS
    Harold Papkoff; Fiscal Year: 1990
    ..Techniques of protein chemistry are used to isolate and characterize highly purified equine and related species of luteinizing hormone, follicle stimulating hormone and chorionic gonadotropin...
  62. Christine A Hrycyna; Fiscal Year: 2014
    ..To this end, we propose the use of a new class of agents - Trojan Horse dimers of known ART to evade P-gp at the BBB and deliver antiretroviral therapies to the brain...
  63. STRUCTURE & FUNCTION OF LIVER ALCOHOL DEHYDROGENASES
    WILLIAM BOSRON; Fiscal Year: 1992
    ..was crystallized and its X-ray structure (the first of a human alcohol dehydrogenase) reveals differences from the horse liver enzyme in the coenzyme binding site, which explains the tighter binding of coenzyme to beta1/beta1 versus ..
  64. STRUCTURE/FUNCTION OF LIVER ALCOHOL DEHYDROGENASES
    WILLIAM BOSRON; Fiscal Year: 2001
    ..was crystallized and its X-ray structure (the first of a human alcohol dehydrogenase) reveals differences from the horse liver enzyme in the coenzyme binding site, which explains the tighter binding of coenzyme to beta1/beta1 versus ..

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  13. Enzymatic process for producing 3-butenal and 3-buten-1-ol
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  18. Composition for diagnosis of excercise stress and use thereof
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  20. METHODS OF USING ZSCAN4 FOR REJUVENATING HUMAN CELLS
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  22. Detection method for species specific identification of nucleic acid of interest
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    Patent Number: WO2015019097-A1; Date:2015-02-12
  24. Immunity-inducing agent
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    Patent Number: WO2015091139-A2; Date:2015-06-25
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    Patent Number: WO2015097030-A1; Date:2015-07-02
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    Patent Number: KR1020140034224-A; Date:2014-03-19
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    Patent Number: KR1020140041566-A; Date:2014-04-04
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    Patent Number: KR1020140064835-A; Date:2014-05-28
  32. METHOD FOR DETECTING PANCREATIC CANCER
    Patent Number: KR1020140048318-A; Date:2014-04-23
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    Patent Number: KR1020150034688-A; Date:2015-04-03
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  35. Method for detecting cancer
    Patent Number: WO2014014082-A; Date:2014-01-23
  36. Method for detecting cancer
    Patent Number: WO2014014086-A; Date:2014-01-23
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  38. Dendritic cell marker and uses thereof
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  39. VISFATIN THERAPEUTIC AGENTS FOR THE TREATMENT OF ACNE AND OTHER CONDITIONS
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  55. Compositions and Methods for Regulation of Tumor Necrosis
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  56. DOG AND HORSE INTERFERONS
    Patent Number: WO8603775-A1; Date:1986-07-03
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    Patent Number: JP2008512996-A; Date:2008-05-01
  58. A new nuclear DNA marker which is useful for species identification comprising ZNF238 and a method for discriminating animal species using the same
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  59. NOVEL CHREBP ISOFORMS AND METHODS USING THE SAME
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  61. Pharmaceutical Composition for Treatment and Prevention of Cancer
    Patent Number: WO2011096534-A; Date:2011-08-11
  62. Pharmaceutical Composition for Treatment and Prevention of Cancer
    Patent Number: WO2011096528-A; Date:2011-08-11