chimpanzee

Summary

Alias: pan troglodytes, chimpansee troglodytes

Top Publications

  1. ncbi Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain
    Sara L Sawyer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:2832-7. 2005
  2. ncbi Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians
    Sandra Blaise
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, UMR 8122 CNRS, Institut Gustave Roussy, 94805 Villejuif, France
    J Virol 78:1050-4. 2004
  3. ncbi Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution
    Sandra Blaise
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de la Recherche Scientifique, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Proc Natl Acad Sci U S A 100:13013-8. 2003
  4. ncbi The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates
    Byeongwoon Song
    Dana Farber Cancer Institute, 44 Binney Street, JFB 824, Boston, MA 02115, USA
    J Virol 79:6111-21. 2005
  5. ncbi Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity
    Steve Dorus
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Nat Genet 36:1326-9. 2004
  6. ncbi Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
  7. ncbi Rapid sequence evolution of the mammalian sex-determining gene SRY
    L S Whitfield
    Department of Genetics, Cambridge University, UK
    Nature 364:713-5. 1993
  8. ncbi Positive selection in MAOA gene is human exclusive: determination of the putative amino acid change selected in the human lineage
    Aida M Andres
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Hum Genet 115:377-86. 2004
  9. ncbi High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot
    A J Jeffreys
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Hum Mol Genet 9:725-33. 2000
  10. ncbi Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition
    Adam Pavlicek
    Genetic Information Research Institute, Mountain View, CA, USA
    Hum Mol Genet 13:2737-51. 2004

Detail Information

Publications205 found, 100 shown here

  1. ncbi Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain
    Sara L Sawyer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:2832-7. 2005
    ..Our study highlights the power of evolutionary analyses, in which positive selection identifies not only the age of genetic conflict but also the interaction interface where this conflict plays out...
  2. ncbi Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians
    Sandra Blaise
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, UMR 8122 CNRS, Institut Gustave Roussy, 94805 Villejuif, France
    J Virol 78:1050-4. 2004
    ..The functional characterization of the identified envelopes is strongly indicative of an ancestral retrovirus infection and endogenization, with some of the envelope functions subsequently retained in evolution...
  3. ncbi Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution
    Sandra Blaise
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de la Recherche Scientifique, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Proc Natl Acad Sci U S A 100:13013-8. 2003
    ....
  4. ncbi The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates
    Byeongwoon Song
    Dana Farber Cancer Institute, 44 Binney Street, JFB 824, Boston, MA 02115, USA
    J Virol 79:6111-21. 2005
    ..The results are consistent with a role for TRIM5alpha in innate immunity against retroviruses...
  5. ncbi Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity
    Steve Dorus
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Nat Genet 36:1326-9. 2004
    ..Our study showcases the intimate relationship between sexual selection and the molecular evolution of reproductive genes...
  6. ncbi Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
    ..We sequenced the complementary DNAs that encode the FOXP2 protein in the chimpanzee, gorilla, orang-utan, rhesus macaque and mouse, and compared them with the human cDNA...
  7. ncbi Rapid sequence evolution of the mammalian sex-determining gene SRY
    L S Whitfield
    Department of Genetics, Cambridge University, UK
    Nature 364:713-5. 1993
    ..The high degree of sequence divergence and the frequency of non-synonymous mutations suggest either that the majority of the coding sequence has no functional significance or that directional selection has occurred...
  8. ncbi Positive selection in MAOA gene is human exclusive: determination of the putative amino acid change selected in the human lineage
    Aida M Andres
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Hum Genet 115:377-86. 2004
    ..a population genetic analysis of the pattern of nucleotide variation in non-human species, including bonobo, chimpanzee, gorilla, and orangutan...
  9. ncbi High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot
    A J Jeffreys
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Hum Mol Genet 9:725-33. 2000
    ....
  10. ncbi Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition
    Adam Pavlicek
    Genetic Information Research Institute, Mountain View, CA, USA
    Hum Mol Genet 13:2737-51. 2004
    ..Previously, a rapidly evolving region with evidence of positive evolutionary selection in human and chimpanzee had been identified only in exon 11...
  11. ncbi Orthologous numbering of great ape and human chromosomes is essential for comparative genomics
    E H McConkey
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Cytogenet Genome Res 105:157-8. 2004
  12. ncbi Evolution of the human ASPM gene, a major determinant of brain size
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genetics 165:2063-70. 2003
    ....
  13. ncbi Common chimpanzees have greater diversity than humans at two of the three highly polymorphic MHC class I genes
    E J Adams
    Department of Structural Biology, Stanford University School of Medicine, CA 94305 5126, USA
    Immunogenetics 51:410-24. 2000
    ..having passed through a narrower population bottleneck than chimpanzees, and with pathogen-mediated selection having favored either preservation of A2 lineage alleles on the human line and/or their extinction on the chimpanzee line.
  14. ncbi Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes
    R R Freimuth
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Graduate School Mayo Clinic, Rochester, MN, USA
    Pharmacogenomics J 4:54-65. 2004
    ..SULT6B1 was also present in chimpanzee and gorilla, differing at only seven encoded amino-acid residues among the three species...
  15. ncbi Sequence variability of a human pseudogene
    R Martinez-Arias
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Genome Res 11:1071-85. 2001
    ..glucocerebrosidase pseudogene (psGBA) for 100 human chromosomes from worldwide populations, as well as for four chimpanzee and four gorilla chromosomes...
  16. ncbi Diversifying selection of the tumor-growth promoter angiogenin in primate evolution
    Jianzhi Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Rm 11 N 104, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mol Biol Evol 19:438-45. 2002
    ..no polymorphism, which may have resulted from a recent selective sweep of a charge-altering substitution in chimpanzee evolution...
  17. ncbi Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene
    ESTHER BETRAN
    Department of Ecology and Evolution, The University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
    Mol Biol Evol 19:654-63. 2002
    ..We sequenced PGAM3 in chimpanzee and macaque and obtained polymorphism data for human coding region...
  18. ncbi Search for genes positively selected during primate evolution by 5'-end-sequence screening of cynomolgus monkey cDNAs
    Naoki Osada
    Division of Genetic Resources, National Institute of Infectious Diseases, Tokyo
    Genomics 79:657-62. 2002
    ..The products of other candidate genes consisted of a cell-surface protein, a member of the lipocalin family, a nuclear transcription factor, and hypothetical proteins...
  19. ncbi Accelerated protein evolution and origins of human-specific features: Foxp2 as an example
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genetics 162:1825-35. 2002
    ..Using comparative analysis of human, chimpanzee, and mouse protein sequences, we identified two genes (PRM2 and FOXP2) with significantly enhanced evolutionary ..
  20. ncbi Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees
    Natasja G de Groot
    Department of Immunobiology, Biomedical Primate Research Centre, P O Box 3306, 2280 GH, Rijswijk, The Netherlands
    Proc Natl Acad Sci U S A 99:11748-53. 2002
    ..have a natural resistance to the development of AIDS, we hypothesize that the selective sweep was caused by the chimpanzee-derived simian immunodeficiency virus (SIVcpz), the closest relative of HIV-1, or a closely related retrovirus...
  21. ncbi A major histocompatibility complex class I allele shared by two species of chimpanzee
    S Cooper
    Department of Structural Biology, Sherman Fairchild Building, Stanford University School of Medicine, Stanford, CA 94305 5400, USA
    Immunogenetics 47:212-7. 1998
    ..Discovery of identical [1101 base pairs (bp)] coding regions at the MHC class I C locus in Pan troglodytes and Pan paniscus, chimpanzee species that diverged approximately 2...
  22. ncbi Beta-defensin 1 gene variability among non-human primates
    Massimiliano Del Pero
    Dipartimento di Biologia Animale e dell Uomo, Universita di Torino, Via Accademia Albertina 13 17, 10123 Turin, Italy
    Immunogenetics 53:907-13. 2002
    ..Compared with these taxa, hylobatids and cercopithecids exhibit 3-4 amino acid substitutions, some of which increase the net charge of the active molecule...
  23. ncbi Evolution of the NANOG pseudogene family in the human and chimpanzee genomes
    Daniel J Fairbanks
    Department of Plant and Animal Sciences, Brigham Young University, Provo, UT 84602, USA
    BMC Evol Biol 6:12. 2006
    ..This article compares the NANOG gene and its pseudogenes in the human and chimpanzee genomes and derives an evolutionary history of this pseudogene family.
  24. ncbi Interferon-inducible gene expression in chimpanzee liver infected with hepatitis C virus
    T Kato
    Medical Research Institute, Nihon University School of Medicine, Tokyo, Japan
    Virology 190:856-60. 1992
    ..C virus (HCV) infection was examined by isolation of HCV-induced genes from a cDNA library constructed from chimpanzee liver during the acute phase of hepatitis C...
  25. ncbi The evolution and genomic landscape of CGB1 and CGB2 genes
    Pille Hallast
    Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia
    Mol Cell Endocrinol 260:2-11. 2007
    ..While the function of these genes is not yet known, they are strongly conserved between human and chimpanzee and exhibit three-fold lower diversity than LHB across human populations with no mutations that would disrupt ..
  26. ncbi High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans
    Sara L Sawyer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Curr Biol 16:95-100. 2006
    ..The unexpectedly high frequency of an impaired retroviral restriction allele among humans is likely to have a significant impact on our ability to ward off future retroviral challenges...
  27. ncbi Molecular evolution of growth hormone gene family in old world monkeys and hominoids
    Chun Ye
    Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
    Gene 350:183-92. 2005
    ..Our results disclosed the complex history of the primate growth hormone gene family and raised intriguing questions on the consequences of these evolutionary events...
  28. ncbi Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 13:489-94. 2004
    ..Additionally, the lineage from the last human/chimpanzee ancestor to humans shows an excess of non-synonymous over synonymous substitutions, which is a signature of ..
  29. ncbi Molecular evolution of microcephalin, a gene determining human brain size
    Yin Qiu Wang
    Key Laboratory of Cellulr and Molecular Evolutioin, Kunming Institute of Zoology, the Chinese Academy of Sciences CAS, Kunming, China
    Hum Mol Genet 13:1131-7. 2004
    ..The codon-based neutrality test also indicated the signal of positive selection on five individual amino acid sites of microcephalin, which may contribute to brain enlargement during primate evolution and human origin...
  30. ncbi Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 13:1139-45. 2004
    ..We therefore propose that genes regulating brain size during development may have the general propensity to contribute to brain evolution in primates and particularly humans...
  31. ncbi Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution
    Joe Gasper
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 79:820-30. 2006
    ..Finally, we observe adaptive evolution in haplotypes segregating for a frameshift mutation that was previously thought to indicate that ZAN was a potential pseudogene...
  32. ncbi The complexity of selection at the major primate beta-defensin locus
    Colin A M Semple
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, UK
    BMC Evol Biol 5:32. 2005
    ..We have used a combination of maximum likelihood based tests and a maximum parsimony based sliding window approach to give a detailed view of the varying modes of selection operating at this locus...
  33. ncbi Comprehensive search for intra- and inter-specific sequence polymorphisms among coding envelope genes of retroviral origin found in the human genome: genes and pseudogenes
    Nathalie de Parseval
    UMR 8122 CNRS, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    BMC Genomics 6:117. 2005
    ..Several of them are conserved during primate evolution, having possibly been co-opted by their host for a physiological role...
  34. ncbi Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios
    Andrew G Clark
    Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Science 302:1960-3. 2003
    Even though human and chimpanzee gene sequences are nearly 99% identical, sequence comparisons can nevertheless be highly informative in identifying biologically important changes that have occurred since our ancestral lineages diverged...
  35. ncbi DNA sequence and comparative analysis of chimpanzee chromosome 22
    H Watanabe
    RIKEN, Genomic Sciences Center, Yokohama 230 0045, Japan
    Nature 429:382-8. 2004
    Human-chimpanzee comparative genome research is essential for narrowing down genetic changes involved in the acquisition of unique human features, such as highly developed cognitive functions, bipedalism or the use of complex language...
  36. ncbi Implications of natural selection in shaping 99.4% nonsynonymous DNA identity between humans and chimpanzees: enlarging genus Homo
    Derek E Wildman
    Center for Molecular Medicine and Genetics and Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Proc Natl Acad Sci U S A 100:7181-8. 2003
    ..Here we compare approximately 90 kb of coding DNA nucleotide sequence from 97 human genes to their sequenced chimpanzee counterparts and to available sequenced gorilla, orangutan, and Old World monkey counterparts, and, on a more ..
  37. ncbi Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans
    S I Khakoo
    Department of Structural Biology, Stanford University, California 94305, USA
    Immunity 12:687-98. 2000
    ..To test this hypothesis, the structure and class I specificity of chimpanzee KIR and CD94:NKG2 receptors were determined and compared to their human counterparts...
  38. ncbi Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G
    Sara L Sawyer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 2:E275. 2004
    ..Despite being only recently discovered, editing of RNA and DNA may thus represent an ancient form of host defense in primate genomes...
  39. ncbi Episodic adaptive evolution of primate lysozymes
    W Messier
    Department of Biological Sciences, University at Albany, State University of New York, 12222, USA
    Nature 385:151-4. 1997
    ..Both adaptive episodes were followed by episodes of negative selection. Thus this approach can detect adaptive and purifying episodes, and localize them to specific lineages during protein evolution...
  40. ncbi Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux
    Fabien Burki
    Center for Integrative Genomics, University of Lausanne, BEP, 1015 Lausanne, Switzerland
    Nat Genet 36:1061-3. 2004
    ..The amino acid changes responsible for the unique brain-specific properties of the enzyme derived from GLUD2 occurred during a period of positive selection after the duplication event...
  41. ncbi Rapid evolution of male reproductive genes in the descent of man
    G J Wyckoff
    Committee on Genetics, University of Chicago, Illinois 60637, USA
    Nature 403:304-9. 2000
    ..evolution of male reproductive genes is observable in primates and is quite notable in the lineages to human and chimpanzee. Nevertheless, rapid evolution by itself is not necessarily an indication of positive darwinian selection; ..
  42. ncbi Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:8337-41. 2003
    ....
  43. ncbi Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis
    P Jeremy Wang
    Howard Hughes Medical Institute, Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Hum Mol Genet 11:2341-6. 2002
    ..The observation that TAF1L can functionally replace TAF(II)250 provides experimental support for the hypothesis that during male meiosis, autosomes provide cellular functions usually supplied by the X chromosome in somatic cells...
  44. ncbi Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms
    Takashi Angata
    Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Proc Natl Acad Sci U S A 101:13251-6. 2004
    ..Nonsynonymous differences between human and chimpanzee orthologs showed uneven distribution between the two beta sheets of the Sia-recognition domain, suggesting ..
  45. ncbi Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 437:100-3. 2005
    ..Here we find, by systematically comparing the DNA sequences of unique, Y-linked genes in chimpanzee and human, which diverged about six million years ago, evidence that in the human lineage, all such genes were ..
  46. ncbi Reduced MIC gene repertoire variation in West African chimpanzees as compared to humans
    Natasja G de Groot
    Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Mol Biol Evol 22:1375-85. 2005
    ..The present population study illustrates that all chimpanzee haplotypes sampled possess the hybrid MICA/B gene...
  47. ncbi All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction
    Sadayuki Ohkura
    Division of Virology, National Institute for Medical Research, Medical Research Council, London, UK
    J Virol 80:8554-65. 2006
    ..2 core structure. It is hypothesized that these three loops form a binding surface for virus and that evolutionary changes in any one of the loops can alter restriction specificity...
  48. ncbi Expansion and divergence of the GH locus between spider monkey and chimpanzee
    Agnès Revol de Mendoza
    Laboratorio de Biologia Molecular, Unidad de Laboratorios de Ingeniería y Expresión Genéticas, Departamento de Bioquimica, Facultad de Medicina, UANL, Av Madero y Dr A Pequeño, Col Mitras Centro, Monterrey CP64460, Mexico
    Gene 336:185-93. 2004
    ..comprising the GH loci of the spider monkey (Ateles geoffroyi), a New-World primate, and of the chimpanzee (Pan troglodytes), an ape...
  49. ncbi Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity
    Igor Zelezetsky
    Department of Biochemistry, University of Trieste, Trieste, I 34127, Italy
    J Biol Chem 281:19861-71. 2006
    ..The evolution of these peptides has thus resulted in distinct mechanisms of action that affect the direct antimicrobial activity and may also modulate accessory antimicrobial functions due to interactions with host cells...
  50. ncbi Effect of species-specificity in auditory-visual intermodal matching in a chimpanzee (Pan troglodytes) and humans
    L Martinez
    Department of Brain and Behavioral Sciences, Primate Research Institute, Kyoto University, Kanrin 41 2, Inuyama, Aichi 484 8506, Japan
    Behav Processes 82:160-3. 2009
    The goal of this study was to compare the performance of a chimpanzee and humans on auditory-visual intermodal matching of conspecifics and non-conspecifics...
  51. ncbi Foramen magnum position variation in Pan troglodytes, Plio-Pleistocene hominids, and recent Homo sapiens: implications for recognizing the earliest hominids
    James C M Ahern
    Department of Anthropology, University of Wyoming, Laramie, Wyoming 82071, USA
    Am J Phys Anthropol 127:267-76. 2005
    ..examined whether or not the positions of biporion and bicarotid relative to basion sufficiently distinguished Pan troglodytes from recent Homo sapiens and Plio-Pleistocene hominids...
  52. ncbi Comparing maternal styles in bonobos (Pan paniscus) and chimpanzees (Pan troglodytes)
    Mieke De Lathouwers
    Department of Biology, University of Antwerp, Antwerp, Belgium
    Am J Primatol 64:411-23. 2004
    ..maternal styles in Cercopithecine species can be applied to bonobos (Pan paniscus) and chimpanzees (Pan troglodytes), 2) determine whether they follow the same pattern, and 3) assess whether species differences in maternal ..
  53. ncbi How the great apes (Pan troglodytes, Pongo pygmaeus, Pan paniscus, Gorilla gorilla) perform on the reversed reward contingency task II: transfer to new quantities, long-term retention, and the impact of quantity ratios
    Jana Uher
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    J Comp Psychol 122:204-12. 2008
    We tested 6 chimpanzees (Pan troglodytes), 3 orangutans (Pongo pygmaeus), 4 bonobos (Pan paniscus), and 2 gorillas (Gorilla gorilla) in the reversed reward contingency task...
  54. ncbi The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application
    Harvey Wong
    Discovery Metabolism and Pharmacokinetics, Bristol Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492 7660, USA
    Drug Metab Dispos 32:1359-69. 2004
    The chimpanzee (CHP) was evaluated as a pharmacokinetic model for humans (HUMs) using propranolol, verapamil, theophylline, and 12 proprietary compounds...
  55. ncbi Histologic examination of bone development in juvenile chimpanzees
    Dawn M Mulhern
    Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560, USA
    Am J Phys Anthropol 122:127-33. 2003
    The purpose of this study is to determine whether histologic skeletal development in chimpanzees (Pan troglodytes) differs from that in humans. Currently, minimal quantitative data are available on the bone histology of great apes...
  56. ncbi Genetic diversity and phylogeographic clustering of SIVcpzPtt in wild chimpanzees in Cameroon
    Fran Van Heuverswyn
    UMR145, Institut de Recherche pour le Developpement, Department of International Health, University of Montpellier 1, 911, Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Virology 368:155-71. 2007
    ..that the clade of simian immunodeficiency viruses (SIVs) infecting west central African chimpanzees (Pan troglodytes troglodytes) and western gorillas (Gorilla gorilla gorilla) comprises the progenitors of human ..
  57. ncbi Patterns of mandibular variation in Pan and Gorilla and implications for African ape taxonomy
    Andrea B Taylor
    Department of Community and Family Medicine, Duke University Medical Center, Box 3907, Durham, NC 27710, USA
    J Hum Evol 44:529-61. 2003
    ..Specifically, we evaluate the purported distinctiveness of P.t. verus from the other two subspecies of Pan troglodytes, and the recent proposals to recognize Nigerian gorillas as a distinct subspecies, Gorilla gorilla diehli, ..
  58. ncbi Chaînes opératoires and resource-exploitation strategies in chimpanzee (Pan troglodytes) nut cracking
    Susana Carvalho
    Department of Anthropology, Faculty of Sciences and Technology, University of Coimbra, Rua do Arco da Traição, 56, 3000 056 Coimbra, Portugal
    J Hum Evol 55:148-63. 2008
    ..We focused on the detection of operational sequences by wild chimpanzees (Pan troglodytes verus) when nut cracking with lithic implements at the sites of Bossou and Diecké, Guinea, West Africa...
  59. ncbi Dimensions and moment arms of the hind- and forelimb muscles of common chimpanzees (Pan troglodytes)
    S K Thorpe
    Department of Human Anatomy and Cell Biology, New Medical School, University of Liverpool, Liverpool, L69 3GE United Kingdom
    Am J Phys Anthropol 110:179-99. 1999
    This paper supplies quantitative data on the hind- and forelimb musculature of common chimpanzees (Pan troglodytes) and calculates maximum joint moments of force as a contribution to a better understanding of the differences between ..
  60. ncbi Paternity and social rank in wild chimpanzees (Pan troglodytes) from the Budongo Forest, Uganda
    Nicholas E Newton-Fisher
    School of Anthropology and Conservation, University of Kent, Canterbury, Kent, UK
    Am J Phys Anthropol 142:417-28. 2010
    ..patterns of paternity and male dominance rank in the Sonso community of wild East African chimpanzees (Pan troglodytes schweinfurthii) in the Budongo Forest, Uganda...
  61. ncbi Metacarpal trabecular architecture variation in the chimpanzee (Pan troglodytes): Evidence for locomotion and tool-use?
    Richard A Lazenby
    University of Northern British Columbia, Prince George, BC, Canada V2N4Z9
    Am J Phys Anthropol 144:215-25. 2011
    ..Two subspecies, West African Pan troglodytes verus from the Taï Forest, Côte d'Ivoire (n = 12) and Central African P. t...
  62. ncbi Nonlinear acoustics in the pant hoots of common chimpanzees (Pan troglodytes): vocalizing at the edge
    Tobias Riede
    National Center for Voice and Speech, Denver Center for the Performing Arts, CO 80204, USA
    J Acoust Soc Am 121:1758-67. 2007
    Common chimpanzee (Pan troglodytes) "pant hoots" are multi-call events that build from quiet, consistently harmonic introductory sounds to loud, screamlike "climax" calls with acoustic irregularities known as "..
  63. ncbi Chimpanzee grouping patterns and food availability in Mahale Mountains National Park, Tanzania
    Noriko Itoh
    Cultural, Regional and Historic Studies on the Environment Cultural Anthropology, Department of Studies in Human Coexistence, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    Primates 48:87-96. 2007
    ..was to test for a correlation between party size and food (fruit) availability among the M group chimpanzees (Pan troglodytes) in the Mahale Mountains, Tanzania...
  64. ncbi Use of intrauterine devices (IUDs) for contraception in the common chimpanzee (Pan troglodytes)
    K G Gould
    Yerkes Regional Primate Research Center of Emory University, Atlanta, GA 30322, USA
    J Med Primatol 29:63-9. 2000
    The common chimpanzee (Pan troglodytes) is a species phylogenetically very close to man. It was not many years ago that the captive population of chimpanzees (P...
  65. ncbi Evidence from Cameroon reveals differences in the genetic structure and histories of chimpanzee populations
    Mary Katherine Gonder
    Department of Biological Sciences, University at Albany State University of New York, Albany, NY 12222, USA
    Proc Natl Acad Sci U S A 108:4766-71. 2011
    The history of the genus Pan is a topic of enduring interest. Chimpanzees (Pan troglodytes) are often divided into subspecies, but the population structure and genetic history of chimpanzees across Africa remain unclear...
  66. ncbi Fifty years of chimpanzee demography at Taronga Park Zoo
    Judith Littleton
    Department of Anthropology, University of Auckland, Auckland, New Zealand
    Am J Primatol 67:281-98. 2005
    There has been a captive Pan troglodytes colony at Taronga Park Zoo in Sydney, Australia, since the mid-1930s...
  67. ncbi Measurement of eye-gaze in chimpanzees (Pan troglodytes)
    Emily J Bethell
    Department of Psychology, University of Portsmouth, Hampshire, UK
    Am J Primatol 69:562-75. 2007
    ..This study presents the first documentation of the surface eye movements of the chimpanzee, Pan troglodytes, in order to determine the behavioral forms of eye-gaze and their saliency as signals, document their ..
  68. ncbi Menstrual cycles continue into advanced old age in the common chimpanzee (Pan troglodytes)
    AGNES LACREUSE
    Department of Psychology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Biol Reprod 79:407-12. 2008
    ..long-held consensus among reproductive scientists has been that our closest living relative, the chimpanzee (Pan troglodytes), experiences menstrual cycles until death...
  69. ncbi Comparative microanatomy of the orbicularis oris muscle between chimpanzees and humans: evolutionary divergence of lip function
    Carolyn R Rogers
    Division of Plastic Surgery, Department of Surgery, School of Medicine, University of Wisconsin Hospital and Clinics, USA
    J Anat 214:36-44. 2009
    ..As the chimpanzee (Pan troglodytes) is the closest living relative of humans, a comparison of the orbicularis oris muscle between these species ..
  70. ncbi The nature of culture: technological variation in chimpanzee predation on army ants revisited
    Caspar Schoning
    Institute of Biology, Department of Population Biology, University of Copenhagen, Copenhagen 2100, Denmark
    J Hum Evol 55:48-59. 2008
    Chimpanzee (Pan troglodytes) predation on army ants (Dorylus, subgenus Anomma) is an impressive example of skillful use of elementary technology, and it has been suggested to reflect cultural differences among chimpanzee communities...
  71. ncbi Chimpanzee (Pan troglodytes) and orangutan (Pongo abelii) forethought: self-control and pre-experience in the face of future tool use
    Mathias Osvath
    Lunds University Cognitive Science, Lund, Sweden
    Anim Cogn 11:661-74. 2008
    ..In a series of four experiments based on tool use, we demonstrate that chimpanzees (Pan troglodytes) and orangutans (Pongo abelii) override immediate drives in favor of future needs, and they do not merely ..
  72. ncbi Normal vaginal flora in chimpanzees (Pan troglodytes): qualitative and quantitative study
    Kazuhiro Noguchi
    Division of Microbiology and Genetics, Center for Animal Resources and Development, Institute of Resource Development and Analysis, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Comp Med 54:705-12. 2004
    ..To clarify our speculation, we examined the development of the vaginal flora in chimpanzees (Pan troglodytes)...
  73. ncbi Campylobacter troglodytis sp. nov., isolated from feces of human-habituated wild chimpanzees (Pan troglodytes schweinfurthii) in Tanzania
    Taranjit Kaur
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24061, USA
    Appl Environ Microbiol 77:2366-73. 2011
    ..In this study, we analyzed 71 fecal samples collected from 2 different wild chimpanzee (Pan troglodytes) populations with different histories in relation to their proximity to humans. Campylobacter spp...
  74. ncbi Do chimpanzees (Pan troglodytes) spontaneously take turns in a reciprocal cooperation task?
    Shinya Yamamoto
    Primate Research Institute, Kyoto University, Aichi, Japan
    J Comp Psychol 123:242-9. 2009
    ..The authors tested whether pairs of chimpanzees (Pan troglodytes) would achieve reciprocal cooperation, that is, whether chimpanzees take turns playing donor and recipient ..
  75. ncbi A cross-setting study of chimpanzee (Pan troglodytes) personality structure and development: zoological parks and Yerkes National Primate Research Center
    Alexander Weiss
    Department of Psychology, The University of Edinburgh, Edinburgh, UK
    Am J Primatol 69:1264-77. 2007
    ..These findings suggest that, whereas there may be differences in the ease with which ratings are made, personality structure, and development are largely consistent across widely differing settings...
  76. ncbi A new entodiniomorphid ciliate, Troglocorys cava n. g., n. sp., from the wild eastern chimpanzee (Pan troglodytes schweinfurthii) from Uganda
    Toshihiro Tokiwa
    Department of Parasitology, Nippon Veterinary and Life Science University, Musashino, Tokyo 180 8602, Japan
    J Eukaryot Microbiol 57:115-20. 2010
    Troglocorys cava n. g., n. sp. is described from the feces of wild eastern chimpanzee, Pan troglodytes schweinfurthii, in Uganda...
  77. ncbi Auditory ERPs to stimulus deviance in an awake chimpanzee (Pan troglodytes): towards hominid cognitive neurosciences
    Ari Ueno
    The University of Tokyo, Tokyo, Japan
    PLoS ONE 3:e1442. 2008
    For decades, the chimpanzee, phylogenetically closest to humans, has been analyzed intensively in comparative cognitive studies...
  78. ncbi Evidence of cave use by savanna chimpanzees (Pan troglodytes verus) at Fongoli, Senegal: implications for thermoregulatory behavior
    J D Pruetz
    Department of Anthropology, Iowa State University, 324 Curtiss Hall, Ames, IA 50011, USA
    Primates 48:316-9. 2007
    ..However, little is known about the responses of human's closest living relative, the chimpanzee (Pan troglodytes), to similar environmental stressors...
  79. ncbi Reproductive endocrinology of wild female chimpanzees (Pan troglodytes schweinfurthii): methodological considerations and the role of hormones in sex and conception
    Melissa Emery Thompson
    Department of Anthropology, Harvard University, Cambridge, Massachusetts 02138, USA
    Am J Primatol 67:137-58. 2005
    Fecal and urine samples were collected from 81 female East African chimpanzees (Pan troglodytes schweinfurthii) in three major study populations in Gombe National Park, Tanzania, and Budongo Forest Reserve and Kibale National Park, ..
  80. ncbi The geographic apportionment of mitochondrial genetic diversity in east African chimpanzees, Pan troglodytes schweinfurthii
    T L Goldberg
    Harvard University, Department of Anthropology, USA
    Mol Biol Evol 14:976-84. 1997
    This study is a geographically systematic genetic survey of the easternmost subspecies of chimpanzee, Pan troglodytes schweinfurthii...
  81. ncbi Chimpanzee (Pan troglodytes) anticipation of food return: coping with waiting time in an exchange task
    V Dufour
    Ethology Research, Animal Science Department, Biomedical Primate Research Centre, Rijswijk, Netherlands
    J Comp Psychol 121:145-55. 2007
    ..The authors investigated the abilities of 5 chimpanzees (Pan troglodytes) to cope with increasing waiting duration in exchange tasks...
  82. ncbi Visual search for human gaze direction by a Chimpanzee (Pan troglodytes)
    Masaki Tomonaga
    Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan
    PLoS ONE 5:e9131. 2010
    ..We examined whether this "stare-in-the-crowd" effect occurs in chimpanzees (Pan troglodytes), whose eye morphology differs from that of humans (i.e., low-contrast eyes, dark sclera).
  83. ncbi Specific gravity as an alternative to creatinine for estimating urine concentration in captive and wild chimpanzee (Pan troglodytes) Samples
    Stephanie F Anestis
    Department of Anthropology, Reproductive Ecology Laboratory, Yale University, New Haven, CT 06520 8277, USA
    Am J Primatol 71:130-5. 2009
    ..We found that specific gravity and creatinine were highly correlated in both captive (N=124) and wild (N=13) chimpanzee samples, and that specific gravity measurement was robust to actual and simulated transport conditions and ..
  84. ncbi Effects of aging on hematology and serum clinical chemistry in chimpanzees (Pan troglodytes)
    Elaine N Videan
    Primate Foundation of Arizona, Mesa, Arizona, USA
    Am J Primatol 70:327-38. 2008
    ..However, few studies have examined physiological aging in chimpanzees, despite the increasing age of the chimpanzee population...
  85. ncbi Cultural innovation and transmission of tool use in wild chimpanzees: evidence from field experiments
    Dora Biro
    Primate Research Institute, Kyoto University, Japan
    Anim Cogn 6:213-23. 2003
    Chimpanzees (Pan troglodytes) are the most proficient and versatile users of tools in the wild...
  86. ncbi The contribution of long-term research at Gombe National Park to chimpanzee conservation
    Anne E Pusey
    Department of Ecology, Evolution and Behavior, University of Minnesota, St Paul, MN 55108, USA
    Conserv Biol 21:623-34. 2007
    ..1) Jane Goodall's groundbreaking discoveries of chimpanzee (Pan troglodytes) tool use, hunting, and complex social relationships in what was then a game reserve drew attention to the ..
  87. ncbi Evolution of pro-protamine P2 genes in primates
    J D Retief
    Department of Medical Biochemistry, Faculty of Medicine, University of Calgary, Alberta, Canada
    Eur J Biochem 214:609-15. 1993
    ..the orangutan, Pongo pygmaeus, gorilla, Gorilla gorilla and two species of chimpanzee Pan paniscus and Pan troglodytes represent a second ape family (Pongidae). These pro-P2 genes are compared with that of human [Domenjoud, L...
  88. ncbi Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder
    H Stefan Bracha
    Department of Veterans Affairs, Pacific Islands Health Care System, and Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A Burns School of Medicine, University of Hawaii, Honolulu 96813 2830, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:827-53. 2006
    ..for by oligogenic (and not necessarily polygenic) transmission, and C) insights from the initial sequence of the chimpanzee genome and comparison with the human genome by the Chimpanzee Sequencing and Analysis Consortium published in ..
  89. ncbi Patterns of gastro-intestinal parasites and commensals as an index of population and ecosystem health: the case of sympatric western chimpanzees (Pan troglodytes verus) and guinea baboons (Papio hamadryas papio) at Fongoli, Senegal
    Michaela E Howells
    Department of Anthropology, University of Colorado, Boulder, CO, USA
    Am J Primatol 73:173-9. 2011
    ..endoparasitic and commensal prevalence and richness as proxies of population health for western chimpanzees (Pan troglodytes verus) and sympatric guinea baboons (Papio hamadryas papio) at Fongoli, Senegal, a site dominated by woodland-..
  90. ncbi Mass spectral analyses of the two major apolipoproteins of great ape high density lipoproteins
    Donald L Puppione
    The Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA
    Comp Biochem Physiol Part D Genomics Proteomics 4:305-9. 2009
    The two major apolipoproteins associated with human and chimpanzee (Pan troglodytes) high density lipoproteins (HDL) are apoA-I and dimeric apoA-II...
  91. ncbi Does space in the jaw influence the timing of molar crown initiation? A model using baboons (Papio anubis) and great apes (Pan troglodytes, Pan paniscus)
    Julia C Boughner
    Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, 2199 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada
    J Hum Evol 46:255-77. 2004
    Radiographic and histological studies of baboon (Papio hamadryas, P. anubis) and chimpanzee (Pan troglodytes) permanent tooth development have found that periods of molar crown mineralization overlap markedly in chimpanzees but are ..
  92. ncbi Mass spectral analyses of the two major apolipoproteins of great ape high density lipoproteins
    Donald L Puppione
    The Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Comp Biochem Physiol Part D Genomics Proteomics 4:305-9. 2009
    The two major apolipoproteins associated with human and chimpanzee (Pan troglodytes) high density lipoproteins (HDL) are apoA-I and dimeric apoA-II...
  93. ncbi Experimental Onchocerca volvulus infections in mangabey monkeys (Cercocebus atys) compared to infections in humans and chimpanzees (Pan troglodytes)
    M L Eberhard
    Division of Parasitic Diseases, Centers for Disease Control, Atlanta, Georgia
    Am J Trop Med Hyg 44:151-60. 1991
    ..One chimpanzee and two mangabey monkeys developed antibody activity to at least three different antigens...
  94. ncbi Prevalence and genetic diversity of simian immunodeficiency virus infection in wild-living red colobus monkeys (Piliocolobus badius badius) from the Taï forest, Côte d'Ivoire SIVwrc in wild-living western red colobus monkeys
    Sabrina Locatelli
    UMR 145, Institut de Recherche pour le Developpement, and University of Montpellier 1, Montpellier, France
    Infect Genet Evol 8:1-14. 2008
    ..It is now well established that the clade of SIVs infecting west-central African chimpanzees (Pan troglodytes troglodytes) and western gorillas (Gorilla gorilla gorilla) represent the progenitors of human ..
  95. ncbi Phylogenetic conservation of the androgen receptor AR45 variant form in placental mammals
    Bertram Weiss
    Target Discovery, Bayer Schering Pharma AG, D 13342 Berlin, Germany
    Gene 399:105-11. 2007
    ..found exon 1B to be conserved in the syntenic chromosomal region of non-human primates such as the chimpanzee Pan troglodytes, the orang-utan Pongo pygmaeus, the macaque Macaca mulatta and the marmoset Callithrix jacchus, and of the ..
  96. ncbi The 48 bp centromeric repeat is a functionally conserved motif in great apes and man showing protein-binding properties
    Carsten M Pusch
    Institute of Anthropology and Human Genetics, Eberhard Karls University, Tubingen, Germany
    Electrophoresis 23:20-6. 2002
    ..Here, we report the identification of centromeric 48 bp motifs, isolated from chimpanzee and orang-utan using an orthologous human DNA probe...
  97. ncbi Survey of gorillas (Gorilla gorilla gorilla) and chimpanzees (Pan troglodytes troglodytes) in Southwestern Cameroon
    Adele Matthews
    Institut für Anthropolgie und Humanbiologie, Freie Universitat Berlin, Albrecht Thaer Weg 6, 14195 Berlin, Germany
    Primates 45:15-24. 2004
    ..gorilla) and the central chimpanzee (Pan t...
  98. ncbi Phylogenetic analysis of simian T-lymphotropic virus Type I (STLV-I) in common chimpanzees (Pan troglodytes): evidence for interspecies transmission of the virus between chimpanzees and humans in Central Africa
    A F Voevodin
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Virology 238:212-20. 1997
    Serum and peripheral blood leukocytes from the chimpanzees (Pan troglodytes) of the colony of the Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, NIH, were tested for the presence of ..
  99. ncbi Masticatory form and function in the African apes
    Andrea B Taylor
    Departments of Community and Family Medicine Division of Physical Therapy and Biological Anthropology and Anatomy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Phys Anthropol 117:133-56. 2002
    ..whether Pan paniscus, the pygmy chimpanzee (or bonobo), consumes greater quantities of THV as compared to Pan troglodytes, the common chimpanzee...
  100. ncbi Directionality of point mutation and 5-methylcytosine deamination rates in the chimpanzee genome
    Cizhong Jiang
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    BMC Genomics 7:316. 2006
    ..To date, there is no genome-wide analysis of mutation direction or methylation-dependent transition rates in the chimpanzee or its categorized genomic regions.
  101. ncbi Lethal pneumonia in a captive juvenile chimpanzee (Pan troglodytes) due to human-transmitted human respiratory syncytial virus (HRSV) and infection with Streptococcus pneumoniae
    Claudia A Szentiks
    Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany
    J Med Primatol 38:236-40. 2009
    During an outbreak of respiratory disease in captive chimpanzees (Pan troglodytes), gorillas (Gorilla gorilla), Bornean orangutans (Pongo pygmaeus), and red-capped mangabeys (Cercocebus torquatus) also staff members showed non-specific ..

Research Grants99

  1. CHIMERIC VIRUS PRIMATE MODEL OF HEPATITIS C
    STANLEY LEMON; Fiscal Year: 2005
    ..The chimpanzee (Pan troglodytes) is the only animal species permissive for infection with this virus...
  2. ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY
    Thomas Rowell; Fiscal Year: 2007
    The biomedical and behavioral research community has long recognized the importance of chimpanzees (Pan troglodytes) as an animal model. Several measures have been instituted to stabilize populations, which are threatened in the wild...
  3. ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY
    Thomas Rowell; Fiscal Year: 2009
    The biomedical and behavioral research community has long recognized the importance of chimpanzees (Pan troglodytes) as an animal model. Several measures have been instituted to stabilize populations, which are threatened in the wild...
  4. ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY
    Thomas Rowell; Fiscal Year: 2007
    The biomedical and behavioral research community has long recognized the importance of chimpanzees (Pan troglodytes) as an animal model. Several measures have been instituted to stabilize populations, which are threatened in the wild...
  5. ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY
    Thomas J Rowell; Fiscal Year: 2010
    The biomedical and behavioral research community has long recognized the importance of chimpanzees (Pan troglodytes) as an animal model. Several measures have been instituted to stabilize populations, which are threatened in the wild...
  6. HCV SPECIFIC T CELL RESPONSES
    Christopher Walker; Fiscal Year: 2003
    ..The common chimpanzee (Pan troglodytes) is the only animal model for studying mechanisms of protective immunity against HCV...
  7. Evolution of Aging and Dementia in Female Primates
    James Herndon; Fiscal Year: 2007
    ..be understood by comparing human's brain and cognitive aging with the same features in our closest relative, the chimpanzee, and in the most widely studied biomedical model of human aging, the rhesus monkey...
  8. Function of saitohin, a novel protein that confers susceptibility to dementia
    Athena Andreadis; Fiscal Year: 2007
    ..STH is present and expressed exclusively in the primates most closely related to humans (chimpanzee, bonobo and gorilla)...
  9. Molecular Epidemiology and Natural History of SIVcpz
    Beatrice H Hahn; Fiscal Year: 2010
    ..We also traced the origin of pandemic and non-pandemic HIV-1 to distinct chimpanzee communities in southern Cameroon (Science 2006), discovered HIV-1 group O-like viruses in wild gorillas (Nature ..
  10. Molecular Epidemiology and Natural History of SIVcpz
    Beatrice Hahn; Fiscal Year: 2009
    ..We also traced the origin of pandemic and non-pandemic HIV-1 to distinct chimpanzee communities in southern Cameroon (Science 2006), discovered HIV-1 group O-like viruses in wild gorillas (Nature ..
  11. Nuclear integrations of mitochondrial DNA in great apes
    Nicola Anthony; Fiscal Year: 2007
    ..First, the strategy is (1) to screen Numts from chimpanzee and gorilla BAC libraries for nuclear insertions, as well as to search nuclear-enriched DNA phage libraries from ..
  12. Identifying enhancers with human-specific developmental functions
    James P Noonan; Fiscal Year: 2010
    ..developmental enhancer that has gained a robust limb expression domain relative to the orthologous elements from chimpanzee and rhesus macaque. This domain includes the presumptive anterior wrist and proximal thumb...
  13. Hepatitis C Virus and Hepatocellular Carcinoma
    Srikanta Dash; Fiscal Year: 2006
    ..In addition, we showed that we could transmit HCV to a chimpanzee after intravenous inoculation of HCV derived from transfected HepG2 cells...
  14. EVOLUTION, SELECTION & ORIGINS OF CLASS I MHC MOLECULES
    Peter Parham; Fiscal Year: 2001
    ..For this purpose the common chimpanzee and the human species provide an ideal system...
  15. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2010
    ..In this context we studied Patr-AL, a novel and chimpanzee-specific MHC class I that is encoded by a novel, non- polymorphic gene, with distinctive tissue distribution, ..
  16. Cellular Learning and information Outside of the Brain
    Michael Levin; Fiscal Year: 2005
    ..such as memory in plants and protozoa, and the occasional hydrocephalic patient with <30% of the cortex of a chimpanzee but above-normal intelligence) suggest that we have much to learn about the substratum of memories and the ..
  17. Hepatitis C: Studies of Immunity and Pathogenesis
    Charles Rice; Fiscal Year: 2007
    ..Prior to testing in mouse and chimpanzee models of HCV infection, he will work with Dr. Rice to evaluate their anti-HCV efficacy in cell culture. Dr...
  18. Engineered 3-D Human Liver Tissue for Hepatitis Studies
    BRIAN NAUGHTON; Fiscal Year: 2004
    ..Unfortunately, to date the only non-human animal models are the chimpanzee and, with a variety of severe limitations, an immunodeficient xenotransplant mouse model...
  19. Resolution of Acute Hepatitis B Virus Infections in Chimpanzees
    Robert Lanford; Fiscal Year: 2007
    ..However, the amount of hepatocyte destruction in the chimpanzee experiments was not determined...
  20. Genetic Vaccine to Rabies Virus
    Hildegund Ertl; Fiscal Year: 2006
    ..The vaccines to be evaluated are based on an E1-deleted simian adenoviral vector derived from a chimpanzee isolate...
  21. Plant-derived vaccines against hepatitis C Cooperative *
    Charles Arntzen; Fiscal Year: 2007
    ..gpE1 and gpE2 are the leading vaccine candidates for antibody-mediated protection, showing protection in chimpanzee. However, gpE1/gpE2 is currently produced in cultured mammalian cells, with a limited capacity for scale-up to ..