Alias: dogs, Canis familiaris, beagle dog, beagle dogs, Canis canis, Canis domesticus, Canis lupus familiaris

Top Publications

  1. Abitbol M, Thibaud J, Olby N, Hitte C, Puech J, Maurer M, et al. A canine Arylsulfatase G (ARSG) mutation leading to a sulfatase deficiency is associated with neuronal ceroid lipofuscinosis. Proc Natl Acad Sci U S A. 2010;107:14775-80 pubmed publisher
    ..a late-onset form of NCL recessively segregates in US and French pedigrees of American Staffordshire Terrier (AST) dogs. Through combined association, linkage, and haplotype analyses, we mapped the disease locus to a single region of ..
  2. Parker H, VonHoldt B, Quignon P, Margulies E, Shao S, Mosher D, et al. An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs. Science. 2009;325:995-8 pubmed publisher
    ..By using a multibreed association analysis in the domestic dog, we demonstrate that expression of a recently acquired retrogene encoding fibroblast growth factor 4 (fgf4) is ..
  3. Nowak M, Madej J, Dziegiel P. Expression of Breast Cancer Resistance Protein (BCRP-1) in canine mammary adenocarcinomas and adenomas. In Vivo. 2009;23:705-9 pubmed
    ..Localization and intensity of BCRP-1 expression was evaluated in mammary adenocarcinomas and adenomas in dogs. The obtained results were compared to the grade of malignancy (G) of the tumours.
  4. Tokuda S, Higashi T, Furuse M. ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape. PLoS ONE. 2014;9:e104994 pubmed publisher
    ..These results suggest a role for ZO-1 in the regulation of cytoskeleton and shape of cell-cell junctions in MDCK cells and indicate the advantage of knockout analysis in cultured cells. ..
  5. Park H, Lee S, Oh J, Seo K, Song K. Leptin, adiponectin and serotonin levels in lean and obese dogs. BMC Vet Res. 2014;10:113 pubmed publisher
    ..The aim of this study was to find any differences in leptin, adiponectin, and 5HT between lean and obese dogs and to identify correlations among these factors...
  6. Jagannathan V, Bannoehr J, Plattet P, Hauswirth R, Drogemuller C, Drogemuller M, et al. A mutation in the SUV39H2 gene in Labrador Retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the epigenetics of keratinocyte differentiation. PLoS Genet. 2013;9:e1003848 pubmed publisher
    ..We genotyped these variants in larger cohorts of dogs and only one was perfectly associated with the HNPK phenotype in a cohort of more than 500 dogs...
  7. Ahonen S, Arumilli M, Lohi H. A CNGB1 frameshift mutation in Papillon and Phalène dogs with progressive retinal atrophy. PLoS ONE. 2013;8:e72122 pubmed publisher
    Progressive retinal degenerations are the most common causes of complete blindness both in human and in dogs. Canine progressive retinal atrophy (PRA) or degeneration resembles human retinitis pigmentosa (RP) and is characterized by a ..
  8. Hanan S, Jagarlamudi K, Liya W, Ellen H, Staffan E. Quaternary structures of recombinant, cellular, and serum forms of thymidine kinase 1 from dogs and humans. BMC Biochem. 2012;13:12 pubmed publisher
    ..Canine TK1 has not been cloned and studied. Therefore, dog and human TK1 cDNA were cloned and expressed, and the recombinant enzymes characterized...
  9. Bannasch D, Young A, Myers J, Truvé K, Dickinson P, Gregg J, et al. Localization of canine brachycephaly using an across breed mapping approach. PLoS ONE. 2010;5:e9632 pubmed publisher
    The domestic dog, Canis familiaris, exhibits profound phenotypic diversity and is an ideal model organism for the genetic dissection of simple and complex traits...

More Information

Publications115 found, 100 shown here

  1. Torres J, Funk H, Zegers M, ter Beest M. The syntaxin 4 N terminus regulates its basolateral targeting by munc18c-dependent and -independent mechanisms. J Biol Chem. 2011;286:10834-46 pubmed publisher
    ..First, it harbors the sorting motif, which targets syntaxin 4 basolaterally in a munc18c-independent manner and second, it allows for munc18c binding, which stabilizes the protein in a munc18c-dependent manner. ..
  2. Bruun C, Jäderlund K, Berendt M, Jensen K, Spodsberg E, Gredal H, et al. A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy. PLoS ONE. 2013;8:e54547 pubmed publisher
    ..Affected dogs were of both sexes and were ambulatory paraparetic, progressing to non-ambulatory tetraparesis...
  3. Mizuno T, Suzuki R, Umeki S, Okuda M. Crossreactivity of antibodies to canine CD25 and Foxp3 and identification of canine CD4+CD25 +Foxp3+ cells in canine peripheral blood. J Vet Med Sci. 2009;71:1561-8 pubmed
    ..ConA stimulation of canine PBMCs induced Foxp3 and CD25 expression in CD4(+) and CD4(-) cells. These data indicate that the activation of canine lymphocytes might induce the production of adaptive Treg cells, as observed in humans. ..
  4. Safra N, Bassuk A, Ferguson P, Aguilar M, Coulson R, Thomas N, et al. Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans. PLoS Genet. 2013;9:e1003646 pubmed publisher
    ..The variable conditions associated with NTDs occur naturally in dogs, and have been previously reported in the Weimaraner breed...
  5. Drogemuller C, Becker D, Brunner A, Haase B, Kircher P, Seeliger F, et al. A missense mutation in the SERPINH1 gene in Dachshunds with osteogenesis imperfecta. PLoS Genet. 2009;5:e1000579 pubmed publisher
    Osteogenesis imperfecta (OI) is a hereditary disease occurring in humans and dogs. It is characterized by extremely fragile bones and teeth...
  6. Akin B, Chen Z, Jones L. Superinhibitory phospholamban mutants compete with Ca2+ for binding to SERCA2a by stabilizing a unique nucleotide-dependent conformational state. J Biol Chem. 2010;285:28540-52 pubmed publisher
    ..We conclude that PLB decreases Ca(2+) binding to SERCA2a by stabilizing a unique E2.ATP state that is unable to bind thapsigargin or vanadate. ..
  7. Król M, Majchrzak K, Mucha J, Homa A, Bulkowska M, Jakubowska A, et al. CSF-1R as an inhibitor of apoptosis and promoter of proliferation, migration and invasion of canine mammary cancer cells. BMC Vet Res. 2013;9:65 pubmed publisher
    ..As far as we know, the study presented hereby is a pioneering experiment in this field of veterinary medicine...
  8. Cadieu E, Neff M, Quignon P, Walsh K, Chase K, Parker H, et al. Coat variation in the domestic dog is governed by variants in three genes. Science. 2009;326:150-3 pubmed publisher
    ..We performed genome-wide association studies of more than 1000 dogs from 80 domestic breeds to identify genes associated with canine fur phenotypes...
  9. Gearhart P, Gearhart C, Thompson D, Petersen Jones S. Improvement of visual performance with intravitreal administration of 9-cis-retinal in Rpe65-mutant dogs. Arch Ophthalmol. 2010;128:1442-8 pubmed publisher
    To determine the efficacy of intravitreal administration of 9-cis-retinal in restoring visual function in Rpe65-mutant dogs.
  10. Miyadera K, Kato K, Boursnell M, Mellersh C, Sargan D. Genome-wide association study in RPGRIP1(-/-) dogs identifies a modifier locus that determines the onset of retinal degeneration. Mamm Genome. 2012;23:212-23 pubmed publisher
    ..the MLHD pet population, extensive range of the onset age has been observed among RD cases, with some RPGRIP1(-/-) dogs lacking obvious clinical signs...
  11. Guglielmini C, Civitella C, Diana A, Di Tommaso M, Cipone M, Luciani A. Serum cardiac troponin I concentration in dogs with precapillary and postcapillary pulmonary hypertension. J Vet Intern Med. 2010;24:145-52 pubmed publisher
    ..Cardiac troponin I (cTnI) is a circulating biomarker of cardiac damage. Myocardial damage can occur in dogs with precapillary and postcapillary PH...
  12. Rissetto K, Rindt H, Selting K, Villamil J, Henry C, Reinero C. Cloning and expression of canine CD25 for validation of an anti-human CD25 antibody to compare T regulatory lymphocytes in healthy dogs and dogs with osteosarcoma. Vet Immunol Immunopathol. 2010;135:137-45 pubmed publisher proteins expressed on the cell surface (CD4 and CD25) and inside the cell (forkhead box3 (FoxP3)), although in dogs, no anti-canine CD25 antibody exists...
  13. Pratakpiriya W, Seki F, Otsuki N, Sakai K, Fukuhara H, Katamoto H, et al. Nectin4 is an epithelial cell receptor for canine distemper virus and involved in neurovirulence. J Virol. 2012;86:10207-10 pubmed publisher
    ..In dogs with distemper, CDV antigen was preferentially detected in nectin4-positive neurons and epithelial cells, ..
  14. Tengvall K, Kierczak M, Bergvall K, Olsson M, Frankowiack M, Farias F, et al. Genome-wide analysis in German shepherd dogs reveals association of a locus on CFA 27 with atopic dermatitis. PLoS Genet. 2013;9:e1003475 pubmed publisher
    Humans and dogs are both affected by the allergic skin disease atopic dermatitis (AD), caused by an interaction between genetic and environmental factors. The German shepherd dog (GSD) is a high-risk breed for canine AD (CAD)...
  15. Drogemuller C, Becker D, Kessler B, Kemter E, Tetens J, Jurina K, et al. A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy. PLoS ONE. 2010;5:e11258 pubmed publisher
    The polyneuropathy of juvenile Greyhound show dogs shows clinical similarities to the genetically heterogeneous Charcot-Marie-Tooth (CMT) disease in humans...
  16. Wang Y, Liao K, Chen M, Huang Y, Chu R, Chi K. Canine CXCL7 and its functional expression in dendritic cells undergoing maturation. Vet Immunol Immunopathol. 2010;135:128-36 pubmed publisher
    ..It is concluded that dog DCs express high levels of the neutrophil chemotactic factor CXCL7 when stimulated by proinflammatory cytokines, ..
  17. Goldstein O, Guyon R, KUKEKOVA A, Kuznetsova T, Pearce Kelling S, Johnson J, et al. COL9A2 and COL9A3 mutations in canine autosomal recessive oculoskeletal dysplasia. Mamm Genome. 2010;21:398-408 pubmed publisher
    ..Affected dogs exhibit short-limbed dwarfism and severe ocular defects...
  18. Badowska Kozakiewicz A, Malicka E. Expression of cyclooxygenase-2 in neoplasms of the mammary gland in bitches. Pol J Vet Sci. 2010;13:337-42 pubmed
    ..Material for the investigation comprised mammary gland tumours, collected from dogs, the patients of veterinary clinics, during surgical procedures...
  19. Winkler P, Ekenstedt K, Occelli L, Frattaroli A, Bartoe J, Venta P, et al. A large animal model for CNGB1 autosomal recessive retinitis pigmentosa. PLoS ONE. 2013;8:e72229 pubmed publisher
    Retinal dystrophies in dogs are invaluable models of human disease. Progressive retinal atrophy (PRA) is the canine equivalent of retinitis pigmentosa (RP). Similar to RP, PRA is a genetically heterogenous condition...
  20. Honscha K, Schirmer A, Reischauer A, Schoon H, Einspanier A, Gabel G. Expression of ABC-transport proteins in canine mammary cancer: consequences for chemotherapy. Reprod Domest Anim. 2009;44 Suppl 2:218-23 pubmed publisher
    ..Because cBCRP is expressed in all examined tumour probes and induces resistance to doxorubicin, the application of doxorubicin for treatment of canine mammary is inappropriate...
  21. Ishiuchi T, Takeichi M. Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Nat Cell Biol. 2011;13:860-6 pubmed publisher
    ..Thus, we have uncovered a Willin/Par3-aPKC-ROCK pathway that controls epithelial apical morphology...
  22. Tzaban S, Massol R, Yen E, Hamman W, Frank S, Lapierre L, et al. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol. 2009;185:673-84 pubmed publisher
  23. Maeda S, Maeda S, Ohno K, Kaji N, Hori M, Fujino Y, et al. Protease-activated receptor-2 induces proinflammatory cytokine and chemokine gene expression in canine keratinocytes. Vet Immunol Immunopathol. 2013;153:17-25 pubmed publisher
  24. Lapierre L, Avant K, Caldwell C, Oztan A, Apodaca G, Knowles B, et al. Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells. Mol Biol Cell. 2012;23:2302-18 pubmed publisher
    ..These results indicate that Ser-227 phosphorylation of Rab11-FIP2 regulates the composition of both adherens and tight junctions and is intimately involved in the regulation of polarity in epithelial cells. ..
  25. Kathrani A, House A, Catchpole B, Murphy A, German A, Werling D, et al. Polymorphisms in the TLR4 and TLR5 gene are significantly associated with inflammatory bowel disease in German shepherd dogs. PLoS ONE. 2010;5:e15740 pubmed publisher
    Inflammatory bowel disease (IBD) is considered to be the most common cause of vomiting and diarrhoea in dogs, and the German shepherd dog (GSD) is particularly susceptible...
  26. Bush J, Gardiner D, Palmer J, Rajpert De Meyts E, Veeramachaneni D. Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours. Int J Androl. 2011;34:e288-95; discussion e295 pubmed publisher
    ..To compare testicular germ cell tumours (TGCT) in dogs with those of men, archived tissues from 347 cases of canine testicular tumours were morphologically evaluated and ..
  27. Dukes J, Whitley P, Chalmers A. The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS ONE. 2012;7:e28659 pubmed publisher
    ..Therefore, YM201636 treatment blocks the continuous recycling of claudin-1/claudin-2 and delays epithelial barrier formation. ..
  28. Thompson J, Yager J, Best S, Pearl D, Coomber B, Torres R, et al. Canine subcutaneous mast cell tumors: cellular proliferation and KIT expression as prognostic indices. Vet Pathol. 2011;48:169-81 pubmed publisher
    ..A case-control design was used to analyze 60 subcutaneous MCT from 60 dogs, consisting of 24 dogs with subsequent local recurrence and 12 dogs with metastasis, as compared to dogs matched by ..
  29. Kowalewski M, Meyer A, Hoffmann B, Aslan S, Boos A. Expression and functional implications of peroxisome proliferator-activated receptor gamma (PPAR?) in canine reproductive tissues during normal pregnancy and parturition and at antiprogestin induced abortion. Theriogenology. 2011;75:877-86 pubmed publisher
    ..However, no such information is available for the dog. Hence, the expression and possible functions of PPAR? were assessed in corpora lutea (CL) and utero/placental (Ut/..
  30. Zeng R, Farias F, Johnson G, McKay S, Schnabel R, Decker J, et al. A truncated retrotransposon disrupts the GRM1 coding sequence in Coton de Tulear dogs with Bandera's neonatal ataxia. J Vet Intern Med. 2011;25:267-72 pubmed publisher
    Bandera's neonatal ataxia (BNAt) is an autosomal recessive cerebellar ataxia that affects members of the Coton de Tulear dog breed.
  31. Kuchtey J, Olson L, Rinkoski T, Mackay E, Iverson T, Gelatt K, et al. Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet. 2011;7:e1001306 pubmed publisher
    ..In this study, we used genome-wide SNP arrays to map the disease gene in a colony of Beagle dogs with inherited POAG to within a single 4 Mb locus on canine chromosome 20...
  32. Ihara Y, Inai Y, Ikezaki M. Alteration of integrin-dependent adhesion and signaling in EMT-like MDCK cells established through overexpression of calreticulin. J Cell Biochem. 2011;112:2518-28 pubmed publisher
  33. Gill J, Capper D, Vanbellinghen J, Chung S, Higgins R, Rees M, et al. Startle disease in Irish wolfhounds associated with a microdeletion in the glycine transporter GlyT2 gene. Neurobiol Dis. 2011;43:184-9 pubmed publisher
    ..These findings will inform future breeding strategies and enable a rational pharmacotherapy of this new canine disorder. ..
  34. Farias F, Johnson G, Taylor J, Giuliano E, Katz M, Sanders D, et al. An ADAMTS17 splice donor site mutation in dogs with primary lens luxation. Invest Ophthalmol Vis Sci. 2010;51:4716-21 pubmed publisher
    ..reaction amplification of RNA isolated from PLL-affected eyes and from skin fibroblast cultures from PLL-affected dogs. An allelic discrimination assay was used to genotype individual dogs at the splice donor site mutation...
  35. Clark L, Tsai K, Starr A, Nowend K, Murphy K. A missense mutation in the 20S proteasome ?2 subunit of Great Danes having harlequin coat patterning. Genomics. 2011;97:244-8 pubmed publisher
    ..Described herein is the identification of a naturally-occurring mutation of the ubiquitin proteasome system that is associated with a discernable phenotype of dogs.
  36. Barbosa M, Alexandre Pires G, Soares Clemente M, Marques C, Rodrigues O, De Brito T, et al. Cytokine gene expression in the tissues of dogs infected by Leishmania infantum. J Comp Pathol. 2011;145:336-44 pubmed publisher
    ..cytokines (interleukin [IL]-12, interferon [IFN]-?, IL-2 and IL-4) in different tissues and organs of 53 adult dogs with or without clinical signs of leishmaniosis and after treatment for the disease...
  37. Dreger D, Schmutz S. A SINE insertion causes the black-and-tan and saddle tan phenotypes in domestic dogs. J Hered. 2011;102 Suppl 1:S11-8 pubmed publisher
    ..The SINE insertion is present in dogs with the a(t) and a alleles but absent from dogs with the a(w) and a(y) alleles...
  38. Millanta F, Asproni P, Cancedda S, Vignoli M, Bacci B, Poli A. Immunohistochemical expression of COX-2, mPGES and EP2 receptor in normal and reactive canine bone and in canine osteosarcoma. J Comp Pathol. 2012;147:153-60 pubmed publisher
    ..The possibility of blocking the EP2 or the selective inhibition of mPGES-1, rather than COX-2 activity, might decrease the incidence of adverse effects that occur due to the inhibition of prostanoids other than PGE(2). ..
  39. Sharif H, von Euler H, Westberg S, He E, Wang L, Eriksson S. A sensitive and kinetically defined radiochemical assay for canine and human serum thymidine kinase 1 (TK1) to monitor canine malignant lymphoma. Vet J. 2012;194:40-7 pubmed publisher as sensitive as the commercially available TK-REA and TK-Liaison assays for measurement of S-TK1 activity in dogs and humans...
  40. Neff M, Beck J, Koeman J, Boguslawski E, Kefene L, Borgman A, et al. Partial deletion of the sulfate transporter SLC13A1 is associated with an osteochondrodysplasia in the Miniature Poodle breed. PLoS ONE. 2012;7:e51917 pubmed publisher
    ..All affected dogs were homozygous for an ancestral haplotype consistent with a founder effect and an identical-by-descent mutation...
  41. Yoshihama Y, Sasaki K, Horikoshi Y, Suzuki A, Ohtsuka T, Hakuno F, et al. KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells. Curr Biol. 2011;21:705-11 pubmed publisher
    ..These results strongly support the notion that KIBRA regulates epithelial cell polarity by suppressing apical exocytosis through direct inhibition of aPKC kinase activity in the PAR3-aPKC-PAR6 complex. ..
  42. Rivera P, Melin M, Biagi T, Fall T, Haggstrom J, Lindblad Toh K, et al. Mammary tumor development in dogs is associated with BRCA1 and BRCA2. Cancer Res. 2009;69:8770-4 pubmed publisher
    ..single-nucleotide polymorphisms (SNPs; four to nine SNPs per gene) were genotyped by iPLEX in female ESS dogs, 212 CMT cases and 143 controls...
  43. Bryant D, Datta A, Rodriguez Fraticelli A, Peranen J, Martin Belmonte F, Mostov K. A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol. 2010;12:1035-45 pubmed publisher
    ..This Rab11a-directed network directs Cdc42-dependent apical exocytosis during lumen formation, revealing an interaction between the machineries of vesicular transport and polarization. ..
  44. Gregory Bryson E, Bartlett E, Kiupel M, Hayes S, Yuzbasiyan Gurkan V. Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11. BMC Cancer. 2010;10:559 pubmed publisher
    Gastrointestinal stromal tumors (GISTs) are common mesenchymal neoplasms in the gastrointestinal tract of humans and dogs. Little is known about the pathogenesis of these tumors...
  45. Seppala E, Jokinen T, Fukata M, Fukata Y, Webster M, Karlsson E, et al. LGI2 truncation causes a remitting focal epilepsy in dogs. PLoS Genet. 2011;7:e1002194 pubmed publisher
    ..LGI2 should be considered a candidate gene for common remitting childhood epilepsies, and LGI2-to-LGI1 transition for mechanisms of childhood epilepsy remission. ..
  46. Hong S, Osborne T, Ren L, Briggs J, Mazcko C, Burkett S, et al. Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells. Vet Comp Oncol. 2011;9:207-18 pubmed publisher
    ..To include the dog in the development of therapeutics that target ezrin biology, we characterized four new canine OS cell lines and ..
  47. Grall A, Guaguere E, Planchais S, Grond S, Bourrat E, Hausser I, et al. PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans. Nat Genet. 2012;44:140-7 pubmed publisher
    ..insertion-deletion (indel) mutation in PNPLA1 that leads to a premature stop codon in all affected golden retriever dogs. We subsequently found one missense and one nonsense mutation in the catalytic domain of human PNPLA1 in six ..
  48. Maeda S, Ohno K, Nakamura K, Uchida K, Nakashima K, Fukushima K, et al. Mucosal imbalance of interleukin-1? and interleukin-1 receptor antagonist in canine inflammatory bowel disease. Vet J. 2012;194:66-70 pubmed publisher
    ..expression of IL-1? and IL-1Ra mRNA by real-time RT-PCR and expression of IL-1? and IL-1Ra protein by ELISA in 21 dogs with IBD, 15 dogs with intestinal lymphoma ('inflammatory' controls) and 20 healthy Beagles ('healthy' controls)...
  49. Majchrzak K, Pawłowski K, Orzechowska E, Dolka I, Mucha J, Motyl T, et al. A role of ghrelin in canine mammary carcinoma cells proliferation, apoptosis and migration. BMC Vet Res. 2012;8:170 pubmed publisher
    ..Our experiments conducted in vitro confirmed that ghrelin promotes cancer development and metastasis. ..
  50. Mattila P, Kinlough C, Bruns J, Weisz O, Hughey R. MUC1 traverses apical recycling endosomes along the biosynthetic pathway in polarized MDCK cells. Biol Chem. 2009;390:551-6 pubmed publisher
    ..Moreover, MUC1 expressed for brief periods in MDCK cells co-localized with GFP-MyoVbT. We conclude that MUC1 traffics to the apical surface via AREs in polarized renal epithelial cells. ..
  51. Koch A, Poirier F, Jacob R, Delacour D. Galectin-3, a novel centrosome-associated protein, required for epithelial morphogenesis. Mol Biol Cell. 2010;21:219-31 pubmed publisher
    ..Collectively, these data establish galectin-3 as a key determinant in epithelial morphogenesis via its effect on centrosome biology. ..
  52. Miyadera K, Kato K, Aguirre Hernandez J, Tokuriki T, Morimoto K, Busse C, et al. Phenotypic variation and genotype-phenotype discordance in canine cone-rod dystrophy with an RPGRIP1 mutation. Mol Vis. 2009;15:2287-305 pubmed
    ..The RPGRIP1 insertion was screened for in all cases and 200 apparently normal control MLHDs and in 510 dogs from 66 other breed...
  53. Boehlke C, Bashkurov M, Buescher A, Krick T, John A, Nitschke R, et al. Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels. J Cell Sci. 2010;123:1460-7 pubmed publisher
    ..Depletion of Rab23 or expression of dominant-negative Rab23 decreased the ciliary steady state specifically of Smoothened but not EB1 or Kim1, suggesting a role of Rab23 in protein turnover in the cilium. ..
  54. Dos Santos F, Vieira P, Correa Oliveira R, Giunchetti R, Carneiro C, Reis A, et al. Qualitative and quantitative immunohistochemical evaluation of iNOS expression in the spleen of dogs naturally infected with Leishmania chagasi. Parasitol Res. 2011;108:1397-403 pubmed publisher
    ..This study aimed at evaluating immunohistochemically the iNOS expression in the spleen of dogs naturally infected (ID) with Leishmania (L.) chagasi compared with non-infected dogs (NID)...
  55. Chamorro D, Alarcón L, Ponce A, Tapia R, Gonzalez Aguilar H, Robles Flores M, et al. Phosphorylation of zona occludens-2 by protein kinase C epsilon regulates its nuclear exportation. Mol Biol Cell. 2009;20:4120-9 pubmed publisher
    ..These results constitute novel information for understanding the mechanisms that regulate the intracellular fate of ZO-2. ..
  56. Giladi M, Boyman L, Mikhasenko H, Hiller R, Khananshvili D. Essential role of the CBD1-CBD2 linker in slow dissociation of Ca2+ from the regulatory two-domain tandem of NCX1. J Biol Chem. 2010;285:28117-25 pubmed publisher
    ..In conclusion, the dynamic properties of three sites are specifically modified, conserved, diversified, and integrated by the linker in CBD12, thereby generating a wide range dynamic sensor. ..
  57. Ferreira E, Gobbi H, Saraiva B, Cassali G. Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysis. BMC Cancer. 2010;10:61 pubmed publisher
    ..Columnar cell lesions in canine mammary gland are pathologically and immunophenotypically similar to those in human breast. This may suggest that dogs are a suitable model for the comparative study of noninvasive breast lesions.
  58. Kuznetsova T, Zangerl B, Goldstein O, Acland G, Aguirre G. Structural organization and expression pattern of the canine RPGRIP1 isoforms in retinal tissue. Invest Ophthalmol Vis Sci. 2011;52:2989-98 pubmed publisher
    ..The identified exon-intron structure of cRPGRIP1 isoforms provides a basis for evaluating the gene defects underlying inherited retinal disorders in dogs.
  59. Hunter M, ZEGERS M. Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanism. Am J Physiol Cell Physiol. 2010;299:C21-32 pubmed publisher
    ..Taken together, our work shows that DN-Pak1-induced branching morphogenesis requires PIX binding and beta1-integrin signaling. ..
  60. Momose F, Sekimoto T, Ohkura T, Jo S, Kawaguchi A, Nagata K, et al. Apical transport of influenza A virus ribonucleoprotein requires Rab11-positive recycling endosome. PLoS ONE. 2011;6:e21123 pubmed publisher
    ..Similarly, no APM accumulation was observed by overexpression of class II Rab11-FIP mutants lacking RBD. These results suggest that the progeny vRNP makes use of Rab11-dependent RE machinery for APM trafficking. ..
  61. Gama A, Gartner F, Alves A, Schmitt F. Immunohistochemical expression of Epidermal Growth Factor Receptor (EGFR) in canine mammary tissues. Res Vet Sci. 2009;87:432-7 pubmed publisher
    ..On survival analysis, tumours with EGFR overexpression showed a reduced disease-free and overall survival; however these associations failed to reach statistically significant levels. ..
  62. Van Itallie C, Fanning A, Bridges A, Anderson J. ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol Biol Cell. 2009;20:3930-40 pubmed publisher
    ..These studies are the first direct evidence that ZO-1 limits solute permeability in established tight junctions, perhaps by forming a stabilizing link between the barrier and perijunctional actomyosin. ..
  63. Bryan J, Jabbes M, Berent L, Arthur G, Taylor K, Rissetto K, et al. Hypermethylation of the DLC1 CpG island does not alter gene expression in canine lymphoma. BMC Genet. 2009;10:73 pubmed publisher
    ..The canine DLC1 mRNA sequence was derived from normal tissue. Using lymphoid samples from 21 dogs with NHL and 7 normal dogs, the methylation status of the promoter CpG island of the gene was defined for each ..
  64. Goldstein O, Kukekova A, Aguirre G, Acland G. Exonic SINE insertion in STK38L causes canine early retinal degeneration (erd). Genomics. 2010;96:362-8 pubmed publisher
  65. John S, Ribalet B, Weiss J, Philipson K, Ottolia M. Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers. Proc Natl Acad Sci U S A. 2011;108:1699-704 pubmed publisher
    ..FRET studies of CBD1, CBD2, and CBD1-CBD2 peptides displayed Ca(2+)-dependent movements with different apparent affinities. CBD1-CBD2 showed a Ca(2+)-dependent phenotype mirroring full-length NCX but distinct from both CBD1 and CBD2. ..
  66. Downs L, Wallin Håkansson B, Boursnell M, Marklund S, Hedhammar A, Truvé K, et al. A frameshift mutation in golden retriever dogs with progressive retinal atrophy endorses SLC4A3 as a candidate gene for human retinal degenerations. PLoS ONE. 2011;6:e21452 pubmed publisher
    Progressive retinal atrophy (PRA) in dogs, the canine equivalent of retinitis pigmentosa (RP) in humans, is characterised by vision loss due to degeneration of the photoreceptor cells in the retina, eventually leading to complete ..
  67. Gill J, Tsai K, Krey C, Noorai R, Vanbellinghen J, Garosi L, et al. A canine BCAN microdeletion associated with episodic falling syndrome. Neurobiol Dis. 2012;45:130-6 pubmed publisher
    ..Wider testing of a larger population of CKCS dogs without a history of EFS from the USA revealed that carriers are extremely common (12.9%)...
  68. Fanning A, Van Itallie C, Anderson J. Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia. Mol Biol Cell. 2012;23:577-90 pubmed publisher
  69. Ochiai H, Morishita T, Onda K, Sugiyama H, Maruo T. Canine Lat1: molecular structure, distribution and its expression in cancer samples. J Vet Med Sci. 2012;74:917-22 pubmed
    ..Notably, Lat1 expression was observed in the tissues of thyroid cancer, melanoma and hemangiopericytoma. Although the cancer samples examined were not enough, Lat1 may serve as a useful biomarker of cancer cells in veterinary clinic. ..
  70. Kyöstilä K, Cizinauskas S, Seppala E, Suhonen E, Jeserevics J, Sukura A, et al. A SEL1L mutation links a canine progressive early-onset cerebellar ataxia to the endoplasmic reticulum-associated protein degradation (ERAD) machinery. PLoS Genet. 2012;8:e1002759 pubmed publisher
    ..Hereditary ataxias occur in many species, including humans and dogs. Several mutations have been found in humans, but the genetic background has remained elusive in dogs...
  71. Vernau K, Runstadler J, Brown E, Cameron J, Huson H, Higgins R, et al. Genome-wide association analysis identifies a mutation in the thiamine transporter 2 (SLC19A3) gene associated with Alaskan Husky encephalopathy. PLoS ONE. 2013;8:e57195 pubmed publisher
    ..We studied 11 Alaskan Husky dogs with AHE, but found no abnormalities in respiratory chain enzyme activities in muscle and liver, or mutations in ..
  72. Wang Z, Sandiford S, Wu C, Li S. Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling. EMBO J. 2009;28:2360-73 pubmed publisher
    ..Our work identifies Numb as an important regulator of epithelial polarity and cell-cell adhesion and a sensor of HGF signalling or Src activity during EMT. ..
  73. Kato K, Kamida A, Sasaki N, Shastry B. Evaluation of the CYP1B1 gene as a candidate gene in beagles with primary open-angle glaucoma (POAG). Mol Vis. 2009;15:2470-4 pubmed
    ..Inherited glaucoma also occurs in several breeds of dogs including beagles. Primary glaucoma in beagles is inherited as an autosomal recessive trait...
  74. Tushir J, Clancy J, Warren A, Wrobel C, Brugge J, D SOUZA SCHOREY C. Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis. Mol Biol Cell. 2010;21:2355-66 pubmed publisher
  75. Mishra R, Grzybek M, Niki T, Hirashima M, Simons K. Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells. Proc Natl Acad Sci U S A. 2010;107:17633-8 pubmed publisher
    ..Together our results suggest a model wherein such glycosphingolipid-galectin couples form a circuit between the Golgi apparatus and the cell surface that in an epithelial context facilitates the apical sorting of proteins and lipids. ..
  76. Lechuga S, Alarcón L, Solano J, Huerta M, Lopez Bayghen E, Gonzalez Mariscal L. Identification of ZASP, a novel protein associated to Zona occludens-2. Exp Cell Res. 2010;316:3124-39 pubmed publisher
    ..ZASP over-expression blocks the inhibitory activity of ZO-2 on cyclin D1 gene transcription and protein expression. The identification of ZASP helps to unfold the complex nuclear molecular arrays that form on ZO-2 scaffolds. ..
  77. Kathrani A, House A, Catchpole B, Murphy A, Werling D, Allenspach K. Breed-independent toll-like receptor 5 polymorphisms show association with canine inflammatory bowel disease. Tissue Antigens. 2011;78:94-101 pubmed publisher
    Inflammatory bowel disease (IBD) is thought to be the most common cause of vomiting and diarrhoea in dogs. Although IBD can occur in any canine breed, certain breeds are more susceptible...
  78. Kinlough C, Poland P, Gendler S, Mattila P, Mo D, Weisz O, et al. Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal. J Biol Chem. 2011;286:39072-81 pubmed publisher
    ..The cumulative data indicate that the core-glycosylated mucin-like repeats of MUC1 constitute an apical targeting signal. ..
  79. Kornblatt M, Kornblatt J, Hancock M. The interaction of canine plasminogen with Streptococcus pyogenes enolase: they bind to one another but what is the nature of the structures involved?. PLoS ONE. 2011;6:e28481 pubmed publisher
    ..Interestingly, a non-native structure of plasminogen is capable of interacting with native enolase. As far as we can tell, the native structures resist forming stable mixed complexes. ..
  80. Forman O, Penderis J, Hartley C, Hayward L, Ricketts S, Mellersh C. Parallel mapping and simultaneous sequencing reveals deletions in BCAN and FAM83H associated with discrete inherited disorders in a domestic dog breed. PLoS Genet. 2012;8:e1002462 pubmed publisher
    The domestic dog (Canis familiaris) segregates more naturally-occurring diseases and phenotypic variation than any other species and has become established as an unparalled model with which to study the genetics of inherited traits...
  81. Yoshikawa Y, Morimatsu M, Ochiai K, Okuda K, Taoda T, Chikazawa S, et al. Establishment of a PCR analysis method for canine BRCA2. BMC Res Notes. 2012;5:173 pubmed publisher
    ..the full-length canine BRCA2 ORF sequence from two ovaries and a testis obtained from individual healthy mongrel dogs and partially sequence BRCA2 genomic sequences in 20-56 tumor-free dogs, each aged over 6 years...
  82. Downs L, Bell J, Freeman J, Hartley C, Hayward L, Mellersh C. Late-onset progressive retinal atrophy in the Gordon and Irish Setter breeds is associated with a frameshift mutation in C2orf71. Anim Genet. 2013;44:169-77 pubmed publisher
    Progressive retinal atrophy (PRA) in dogs is characterised by the degeneration of the photoreceptor cells of the retina, resulting in vision loss and eventually complete blindness...
  83. Maurer M, Mary J, Guillaud L, Fender M, Pelé M, Bilzer T, et al. Centronuclear myopathy in Labrador retrievers: a recent founder mutation in the PTPLA gene has rapidly disseminated worldwide. PLoS ONE. 2012;7:e46408 pubmed publisher
    ..PTPLA-deficient Labradors will help define the integrated role of PTPLA in the existing CNM gene network. They will be valuable complementary large animal models to test innovative therapies in CNM. ..
  84. Credille K, Minor J, Barnhart K, Lee E, Cox M, Tucker K, et al. Transglutaminase 1-deficient recessive lamellar ichthyosis associated with a LINE-1 insertion in Jack Russell terrier dogs. Br J Dermatol. 2009;161:265-72 pubmed publisher
    ..autosomal recessive ichthyosis have been described in purebred dog breeds, including Jack Russell terrier (JRT) dogs. One cause of gene mutation important to humans and dogs is transposon insertions...
  85. Lavalle G, Bertagnolli A, Tavares W, Cassali G. Cox-2 expression in canine mammary carcinomas: correlation with angiogenesis and overall survival. Vet Pathol. 2009;46:1275-80 pubmed publisher
    Mammary tumors are among the most common neoplastic processes in female dogs. Prostaglandin E2, the catalytic product of Cox-2, may promote tumor development and angiogenesis...
  86. Hilge M, Aelen J, Foarce A, Perrakis A, Vuister G. Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism. Proc Natl Acad Sci U S A. 2009;106:14333-8 pubmed publisher
    ..In contrast to CBD1, the electrostatic switch in CBD2 is isoform- and splice variant-specific and allows for tailored exchange activities. ..
  87. Tokhtaeva E, Sachs G, Vagin O. Assembly with the Na,K-ATPase alpha(1) subunit is required for export of beta(1) and beta(2) subunits from the endoplasmic reticulum. Biochemistry. 2009;48:11421-31 pubmed publisher
  88. Goldstein O, Mezey J, Boyko A, Gao C, Wang W, Bustamante C, et al. An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9. Mol Vis. 2010;16:1549-69 pubmed
    ..Retinal morphology of selected crd3-affected dogs was evaluated by light and electron microscopy...
  89. Ochiai K, Yoshikawa Y, Oonuma T, Tomioka Y, Hashizume K, Morimatsu M. Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeats. Vet J. 2011;190:293-5 pubmed publisher
    ..These results may provide an insight into the effects of missense or truncation mutations in BRCA2 in canine tumours. ..
  90. Poland P, Rondanino C, Kinlough C, Heimburg Molinaro J, Arthur C, Stowell S, et al. Identification and characterization of endogenous galectins expressed in Madin Darby canine kidney cells. J Biol Chem. 2011;286:6780-90 pubmed publisher
  91. Zangerl B, Wickström K, Slavik J, Lindauer S, Ahonen S, Schelling C, et al. Assessment of canine BEST1 variations identifies new mutations and establishes an independent bestrophinopathy model (cmr3). Mol Vis. 2010;16:2791-804 pubmed
    ..a group of retinal disorders known as bestrophinopathies in man and canine multifocal retinopathies (cmr) in the dog. To date, the dog is the only large animal model suitable for the complex characterization and in-depth studies of ..
  92. Kitt K, Nelson W. Rapid suppression of activated Rac1 by cadherins and nectins during de novo cell-cell adhesion. PLoS ONE. 2011;6:e17841 pubmed publisher