Rhinolophus sinicus



Top Publications

  1. Luk H, Li X, Fung J, Lau S, Woo P. Molecular epidemiology, evolution and phylogeny of SARS coronavirus. Infect Genet Evol. 2019;71:21-30 pubmed publisher
    ..sequenced, including 274 from human, 18 from civets and 47 from bats [mostly from Chinese horseshoe bats (Rhinolophus sinicus), n = 30; and greater horseshoe bats (Rhinolophus ferrumequinum), n = 9]...
  2. van Doremalen N, Schäfer A, Menachery V, Letko M, Bushmaker T, Fischer R, et al. SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus). Viruses. 2018;10: pubmed publisher
    Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from Rhinolophus sinicus bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor...
  3. Lau S, Fan R, Luk H, Zhu L, Fung J, Li K, et al. Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins. Emerg Microbes Infect. 2018;7:209 pubmed publisher
    ..12 primary bat cell lines from seven bat species, including Tylonycteris pachypus, Pipistrellus abramus and Rhinolophus sinicus (hosts of Tylonycteris-BatCoV HKU4, Pipistrellus-BatCoV HKU5, and SARS-related-CoV respectively), and ..
  4. Liang L, Luo X, Liu Z, Wang J, Huang T, Li E. Habitat selection and prediction of the spatial distribution of the Chinese horseshoe bat (R. sinicus) in the Wuling Mountains. Environ Monit Assess. 2018;191:4 pubmed publisher
    Habitat selection by the Chinese horseshoe bat (Rhinolophus sinicus) in the Wuling Mountains was studied in this paper...
  5. Wu Z, Yang L, Ren X, Zhang J, Yang F, Zhang S, et al. ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus. J Infect Dis. 2016;213:579-83 pubmed publisher
    ..all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from Rhinolophus sinicus have ORF8s that are identical to that of human SARS-CoV...
  6. Liang Y, Wu L, Zhang Q, Zhou P, Wang M, Yang X, et al. Cloning, expression, and antiviral activity of interferon β from the Chinese microbat, Myotis davidii. Virol Sin. 2015;30:425-32 pubmed publisher
    ..davidii and Rhinolophus sinicus. We provide the first in vitro evidence of IFNβ antiviral activity in microbats, which has important ..
  7. Ge X, Wang N, Zhang W, Hu B, Li B, Zhang Y, et al. Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft. Virol Sin. 2016;31:31-40 pubmed publisher
    ..Six bat species were frequently detected in the cave: Rhinolophus sinicus, Rhinolophus affinis, Hipposideros pomona, Miniopterus schreibersii, Miniopterus fuliginosus, and ..
  8. Lau S, Feng Y, Chen H, Luk H, Yang W, Li K, et al. Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination. J Virol. 2015;89:10532-47 pubmed publisher
    ..Although two SARS-related Rhinolophus sinicus bat CoVs (SARSr-Rs-BatCoVs) previously detected in Chinese horseshoe bats (Rhinolophus sinicus) in Yunnan, ..
  9. Wang B, Yang X, Li W, Zhu Y, Ge X, Zhang L, et al. Detection and genome characterization of four novel bat hepadnaviruses and a hepevirus in China. Virol J. 2017;14:40 pubmed publisher
    ..The hepadnaviruses were discovered in the horseshoe bats, Rhinolophus sinicus and Rhinolophus affinis, and the hepevirus was found in the whiskered bat Myotis davidii...

More Information


  1. Dong D, Lei M, Hua P, Pan Y, Mu S, Zheng G, et al. The Genomes of Two Bat Species with Long Constant Frequency Echolocation Calls. Mol Biol Evol. 2017;34:20-34 pubmed publisher
    ..two rhinolophoid bats-the great leaf-nosed bat (Hipposideros armiger) and the Chinese rufous horseshoe bat (Rhinolophus sinicus)...
  2. Lau S, Ahmed S, Yeung H, Li K, Fan R, Cheng T, et al. Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China. J Gen Virol. 2016;97:3345-3358 pubmed publisher
    ..BtBoV showed a higher detection rate in alimentary samples of Rhinolophus sinicus (5.7?%) than those of other bat species (0.43-1.59?%), supporting R...
  3. Lau S, Ahmed S, Tsoi H, Yeung H, Li K, Fan R, et al. Bats host diverse parvoviruses as possible origin of mammalian dependoparvoviruses and source for bat-swine interspecies transmission. J Gen Virol. 2017;: pubmed publisher
    ..four novel bat bocaparvovirus species (Rp-BtBoV1 and Rp-BtBoV2 from Rhinolophus pusillus, Rs-BtBoV2 from Rhinolophus sinicus and Rol-BtBoV1 from Rousettus leschenaultii) and two novel bat dependoparvovirus species (Rp-BtAAV1 from ..
  4. Li J, Zhang G, Cheng D, Ren H, Qian M, Du B. Molecular characterization of RIG-I, STAT-1 and IFN-beta in the horseshoe bat. Gene. 2015;561:115-23 pubmed publisher
    ..the sequence of RIG-I, STAT-1 and IFN-β in the immortalized cell lines from Rhinolophus affinis and Rhinolophus sinicus. Then, we treated different bat cells, mouse embryonic fibroblasts (MEF) and splenocytes with polyinosinic-..
  5. Shen Y, Liu J, Irwin D, Zhang Y. Parallel and convergent evolution of the dim-light vision gene RH1 in bats (Order: Chiroptera). PLoS ONE. 2010;5:e8838 pubmed publisher
    ..e., various photic environments) during adaptation for the nocturnal lifestyle, and suggest that further attention is needed on the study of the ecology and behavior of bats...
  6. Ai W, Chen S, Chen X, Shen X, Shen Y. Parallel evolution of IDH2 gene in cetaceans, primates and bats. FEBS Lett. 2014;588:450-4 pubmed publisher
    ..We found significant signals of parallel evolution in this gene among these three groups. Parallel evolution of this gene may reflect their parallel evolution towards a higher demand for energy. ..
  7. Ge X, Li J, Yang X, Chmura A, Zhu G, Epstein J, et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature. 2013;503:535-8 pubmed publisher
    ..They also highlight the importance of pathogen-discovery programs targeting high-risk wildlife groups in emerging disease hotspots as a strategy for pandemic preparedness...
  8. Shen Y, Liang L, Li G, Murphy R, Zhang Y. Parallel evolution of auditory genes for echolocation in bats and toothed whales. PLoS Genet. 2012;8:e1002788 pubmed publisher
  9. Shen Y, Lim B, Liu H, Liu J, Irwin D, Zhang Y. Multiple episodes of convergence in genes of the dim light vision pathway in bats. PLoS ONE. 2012;7:e34564 pubmed publisher
  10. Hou Y, Peng C, Yu M, Li Y, Han Z, Li F, et al. Angiotensin-converting enzyme 2 (ACE2) proteins of different bat species confer variable susceptibility to SARS-CoV entry. Arch Virol. 2010;155:1563-9 pubmed publisher
    ..The results show that ACE2s of Myotis daubentoni and Rhinolophus sinicus support viral entry mediated by the SARS-CoV S protein, albeit with different efficiency in comparison to ..