platypus

Summary

Alias: duck-billed platypus, duckbill platypus, Ornithorhynchus anatinus, Ornythorhynchus anatinus

Top Publications

  1. ncbi Genotypic analysis of Mucor from the platypus in Australia
    J H Connolly
    EH Graham Centre for Agricultural Innovation Industry and Investment NSW and Charles Sturt University, Charles Sturt University, PO Box 588, Wagga Wagga, NSW, Australia
    J Wildl Dis 46:55-69. 2010
  2. doi Ornithorhynchus anatinus (platypus) links the evolution of immunoglobulin genes in eutherian mammals and nonmammalian tetrapods
    Yaofeng Zhao
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People s Republic of China
    J Immunol 183:3285-93. 2009
  3. pmc Genome analysis of the platypus reveals unique signatures of evolution
    Wesley C Warren
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 453:175-83. 2008
  4. pmc Disruption and pseudoautosomal localization of the major histocompatibility complex in monotremes
    Juliane C Dohm
    Max Planck Institute for Molecular Genetics, Ihnestr, 63 73, 14195 Berlin, Germany
    Genome Biol 8:R175. 2007
  5. ncbi M6P/IGF2R imprinting evolution in mammals
    J K Killian
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell 5:707-16. 2000
  6. ncbi Evidence for an early appearance of modern post-switch immunoglobulin isotypes in mammalian evolution (II); cloning of IgE, IgG1 and IgG2 from a monotreme, the duck-billed platypus, Ornithorhynchus anatinus
    M Vernersson
    Department of Cell and Molecular Biology, University of Uppsala, The Biomedical Center, Uppsala, Sweden
    Eur J Immunol 32:2145-55. 2002
  7. ncbi The mitochondrial genome of a monotreme--the platypus (Ornithorhynchus anatinus)
    A Janke
    Zoologisches Institut, Universitat Munchen, Germany
    J Mol Evol 42:153-9. 1996
  8. ncbi Distribution of keratin and associated proteins in the epidermis of monotreme, marsupial, and placental mammals
    Lorenzo Alibardi
    Dipartimento di Biologia Evoluzionistica Sperimentale, University of Bologna, 40126, Bologna, Italy
    J Morphol 258:49-66. 2003
  9. ncbi Glucocorticoids in the blood plasma of the platypus Ornithorynchus anatinus
    I R McDonald
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    J Endocrinol 118:407-15. 1988
  10. pmc The oldest platypus and its bearing on divergence timing of the platypus and echidna clades
    Timothy Rowe
    Jackson School of Geosciences, University of Texas, C1100, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 105:1238-42. 2008

Research Grants

  1. Multiplexed Personal Monitoring of Airborne Toxins
    BHARAT ACHARYA; Fiscal Year: 2007
  2. Biophotonics for Detection of West Nile Virus
    Barbara Israel; Fiscal Year: 2002
  3. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2007
  4. Obliquely deposited substrates for detection of Ras
    Barbara Israel; Fiscal Year: 2003
  5. Personal Dosimeter for OPs Using Nano-structured Surface
    Barbara Israel; Fiscal Year: 2006
  6. Biophotonic detection of WNV Abs from Multiple Species
    RENEE HERBER; Fiscal Year: 2007
  7. Liquid crystal based enzyme activity assay
    Barbara Israel; Fiscal Year: 2005
  8. Evolution of sodium channel genes
    Harold Zakon; Fiscal Year: 2009
  9. HORMONAL MODULATION OF A COMMUNICATION SIGNAL
    Harold Zakon; Fiscal Year: 2007
  10. Transformation by Reticuloendotheliosis Virus
    HENRY BOSE; Fiscal Year: 2007

Detail Information

Publications153 found, 100 shown here

  1. ncbi Genotypic analysis of Mucor from the platypus in Australia
    J H Connolly
    EH Graham Centre for Agricultural Innovation Industry and Investment NSW and Charles Sturt University, Charles Sturt University, PO Box 588, Wagga Wagga, NSW, Australia
    J Wildl Dis 46:55-69. 2010
    ..is the only pathogen known to cause significant morbidity and mortality in the free-living platypus (Ornithorhynchus anatinus) in Tasmania...
  2. doi Ornithorhynchus anatinus (platypus) links the evolution of immunoglobulin genes in eutherian mammals and nonmammalian tetrapods
    Yaofeng Zhao
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People s Republic of China
    J Immunol 183:3285-93. 2009
    ..We report in this study that the platypus (Ornithorhynchus anatinus) Ig H chain constant region gene locus contains eight Ig encoding genes, which are arranged in an mu-..
  3. pmc Genome analysis of the platypus reveals unique signatures of evolution
    Wesley C Warren
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 453:175-83. 2008
    We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters...
  4. pmc Disruption and pseudoautosomal localization of the major histocompatibility complex in monotremes
    Juliane C Dohm
    Max Planck Institute for Molecular Genetics, Ihnestr, 63 73, 14195 Berlin, Germany
    Genome Biol 8:R175. 2007
    The monotremes, represented by the duck-billed platypus and the echidnas, are the most divergent species within mammals, featuring a flamboyant mix of reptilian, mammalian and specialized characteristics...
  5. ncbi M6P/IGF2R imprinting evolution in mammals
    J K Killian
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell 5:707-16. 2000
    ..Unless there was convergent evolution of M6P/ IGF2R imprinting and receptor IGF2 binding in marsupials and eutherians, our results also demonstrate that these two functions evolved in a mammalian clade exclusive of monotremes...
  6. ncbi Evidence for an early appearance of modern post-switch immunoglobulin isotypes in mammalian evolution (II); cloning of IgE, IgG1 and IgG2 from a monotreme, the duck-billed platypus, Ornithorhynchus anatinus
    M Vernersson
    Department of Cell and Molecular Biology, University of Uppsala, The Biomedical Center, Uppsala, Sweden
    Eur J Immunol 32:2145-55. 2002
    ..present an analysis of the Ig expression in an egg-laying mammal, a monotreme, the duck-billed platypus (Ornithorhynchus anatinus). Fragments of platypus IgG and IgE cDNA were obtained by a PCR-based screening using degenerate primers...
  7. ncbi The mitochondrial genome of a monotreme--the platypus (Ornithorhynchus anatinus)
    A Janke
    Zoologisches Institut, Universitat Munchen, Germany
    J Mol Evol 42:153-9. 1996
    The complete nucleotide sequence of the mitochondrial genome of a platypus (Ornithorhynchus anatinus) was determined. Its overall genomic organization is similar to that of placental mammals, Xenopus laevis, and fishes...
  8. ncbi Distribution of keratin and associated proteins in the epidermis of monotreme, marsupial, and placental mammals
    Lorenzo Alibardi
    Dipartimento di Biologia Evoluzionistica Sperimentale, University of Bologna, 40126, Bologna, Italy
    J Morphol 258:49-66. 2003
    ..Those skin regions lacking hairs (platypus web), or showing reduced pelage density (wombat) have, respectively, minute or indiscernible KHGs, associated ..
  9. ncbi Glucocorticoids in the blood plasma of the platypus Ornithorynchus anatinus
    I R McDonald
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    J Endocrinol 118:407-15. 1988
    ..PAGE) revealed no evidence for a transcortin-like glucocorticoid- and progesterone-binding protein in platypus plasma...
  10. pmc The oldest platypus and its bearing on divergence timing of the platypus and echidna clades
    Timothy Rowe
    Jackson School of Geosciences, University of Texas, C1100, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 105:1238-42. 2008
    ..mute during two decades of discussion about molecular clock estimates of the timing of divergence between the platypus and echidna clades...
  11. ncbi Karyotypic conservation in the mammalian order monotremata (subclass Prototheria)
    J M Wrigley
    Department of Genetics and Human Variation, La Trobe University, Bundoora, Australia
    Chromosoma 96:231-47. 1988
    The order Monotremata, comprising the platypus and two species of echidna (Australian and Nuigini) is the only extant representative of the mammalian subclass Prototheria, which diverged from subclass Theria (marsupials and placental ..
  12. doi Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire
    Leopold Eckhart
    Department of Dermatology, Medical University of Vienna, Vienna, Austria
    Mol Biol Evol 25:831-41. 2008
    ..Caspase-17, which is most similar to caspase-3, has been conserved among fish, frog, chicken, lizard, and the platypus but is absent from marsupials and placental mammals...
  13. doi The immunoglobulin heavy chain locus in the platypus (Ornithorhynchus anatinus)
    F Gambón-Deza
    Vigo University Hospital Complex, Pontevedra, Spain
    Mol Immunol 46:2515-23. 2009
    ..These data and the characterization of the IGH locus in platypus (Ornithorhynchus anatinus), allow us to elucidate the changes that took place in this genomic region during evolution from reptile ..
  14. pmc Epigenetic modifications on X chromosomes in marsupial and monotreme mammals and implications for evolution of dosage compensation
    Willem Rens
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 OES, United Kingdom
    Proc Natl Acad Sci U S A 107:17657-62. 2010
    ..on somatic cells of the female Australian marsupial possum Trichosurus vulpecula, the female platypus Ornithorhynchus anatinus, and control mouse cells. The two marsupial X's were different for all epigenetic features tested...
  15. pmc Loss of genes implicated in gastric function during platypus evolution
    Gonzalo R Ordóñez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, Fernando Bongera s n, 33006 Oviedo, Spain
    Genome Biol 9:R81. 2008
    The duck-billed platypus (Ornithorhynchus anatinus) belongs to the mammalian subclass Prototheria, which diverged from the Theria line early in mammalian evolution...
  16. ncbi Cyto- and chemoarchitecture of the sensory trigeminal nuclei of the echidna, platypus and rat
    Ken W S Ashwell
    Department of Anatomy, School of Medical Sciences, The University of New South Wales, New South Wales, Sydney 2052, Australia
    J Chem Neuroanat 31:81-107. 2006
    ..trigeminal nucleus and the oralis and interpolaris spinal trigeminal nuclei were substantially larger in the platypus than in either the echidna or rat, but the caudalis subnucleus was similar in size in both monotremes and the rat...
  17. doi Identification of two FoxP3 genes in rainbow trout (Oncorhynchus mykiss) with differential induction patterns
    Tiehui Wang
    Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Mol Immunol 47:2563-74. 2010
    ..fish, amphibians and monotreme mammals compared to eutherian mammals, suggesting that FoxP3 in fish, frog and platypus may have a different role to the human and mouse counterpart that defines the Treg cellular lineage and mediates ..
  18. pmc The thalamus of the monotremes: cyto- and myeloarchitecture and chemical neuroanatomy
    Shawn Mikula
    Centre for Neuroscience, University of California, 1544 Newton Court, Davis, CA 95616, USA
    Philos Trans R Soc Lond B Biol Sci 363:2415-40. 2008
    Echidna and platypus brains were sectioned and stained by Nissl or myelin stains or immunocytochemically for calcium-binding proteins, gamma aminobutyric acid (GABA) or other antigens...
  19. ncbi The unique sex chromosome system in platypus and echidna
    M A Ferguson-Smith
    Cambridge Resource Centre for Comparative Genomics, Department of Veterinary Medicine, Cambridge CB3 0ES, UK
    Genetika 46:1314-9. 2010
    A striking example of the power of chromosome painting has been the resolution of the male platypus karyotype and the pairing relationships of the chain often sex chromosomes...
  20. pmc Phylogenetic analysis of the MS4A and TMEM176 gene families
    Jonathan Zuccolo
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 5:e9369. 2010
    ..In this study, we examined the evolutionary history of the MS4A/TMEM176 families as well as tissue expression of the phylogenetically earliest members, in order to investigate their possible origins in immune cells...
  21. ncbi The hypothalamic supraoptic and paraventricular nuclei of the echidna and platypus
    Ken W S Ashwell
    Department of Anatomy, School of Medical Sciences, The University of New South Wales, Sydney, Australia
    Brain Behav Evol 68:197-217. 2006
    ..tract in two monotremes: the short-beaked echidna (Tachyglossus aculeatus) and the platypus (Ornithorhynchus anatinus)...
  22. ncbi Chemoarchitecture of the monotreme olfactory bulb
    Ken W S Ashwell
    Department of Anatomy, School of Medical Sciences, The University of New South Wales, Sydney, Australia
    Brain Behav Evol 67:69-84. 2006
    The cyto- and chemoarchitecture of the olfactory bulb of two monotremes (shortbeaked echidna and platypus) was studied to determine if there are any chemoarchitectural differences from therian mammals...
  23. pmc Wood consumption by Geoffroyi's spider monkeys and its role in mineral supplementation
    Oscar M Chaves
    Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    PLoS ONE 6:e25070. 2011
    ..In general, wood consumption was focused on trees of Licania platypus (Chrysobalanaceae) and Ficus spp...
  24. ncbi Cyto- and chemoarchitecture of the monotreme olfactory tubercle
    Ken W S Ashwell
    Department of Anatomy, School of Medical Sciences, The University of New South Wales, Sydney, Australia
    Brain Behav Evol 67:85-102. 2006
    This study was undertaken to determine whether the olfactory tubercles of two monotremes (platypus and echidna) showed cyto- or chemoarchitectural differences from the tubercles of therian mammals...
  25. pmc The genomes of the South American opossum (Monodelphis domestica) and platypus (Ornithorhynchus anatinus) encode a more complete purine catabolic pathway than placental mammals
    Alaine C Keebaugh
    Graduate Program in Population Biology, Ecology and Evolution, Emory University, Atlanta, GA 30322, USA
    Comp Biochem Physiol Part D Genomics Proteomics 4:174-8. 2009
    ..in a marsupial, the South American opossum (Monodelphis domestica), and a monotreme, the platypus (Ornithorhynchus anatinus)...
  26. pmc Responses of electroreceptors in the snout of the echidna
    J E Gregory
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    J Physiol 414:521-38. 1989
    ..Similar glands in skin of the platypus have previously been shown to be the sites of electroreceptors. 6...
  27. ncbi Marsupials and Eutherians reunited: genetic evidence for the Theria hypothesis of mammalian evolution
    J K Killian
    Departments of Radiation Oncology and Pathology, Duke University Medical Center, Box 3433, Durham, North Carolina 27710, USA
    Mamm Genome 12:513-7. 2001
    ..growth factor II receptor (M6P/IGF2R), from representatives of all three mammalian groups, including platypus, echidna, opossum, wallaby, hedgehog, mouse, rat, rabbit, cow, pig, bat, tree shrew, colugo, ringtail lemur, and ..
  28. ncbi Immunoglobulin genetics of Ornithorhynchus anatinus (platypus) and Tachyglossus aculeatus (short-beaked echidna)
    Katherine Belov
    Evolutionary Biology Unit, Australian Museum, 6 College Street, Sydney 2010, Australia
    Comp Biochem Physiol A Mol Integr Physiol 136:811-9. 2003
    ..Preliminary analysis of monotreme heavy chain variable region diversity suggests that the platypus primarily uses a single VH clan, while the short-beaked echidna utilises at least 4 distinct VH families which ..
  29. ncbi Sparganosis in the monotremes Tachyglossus aculeatus and Ornithorhynchus anatinus in Australia
    R Whittington
    Healesville Sanctuary, Australia
    J Wildl Dis 28:636-40. 1992
    ..Several plerocercoids also were found in the lung of a platypus (Ornithorhynchus anatinus) associated with parenchymal compression and focal pneumonia.
  30. pmc Sensory receptors in monotremes
    U Proske
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Philos Trans R Soc Lond B Biol Sci 353:1187-98. 1998
    This is a summary of the current knowledge of sensory receptors in skin of the bill of the platypus, Ornithorhynchus anatinus, and the snout of the echidna, Tachyglossus aculeatus...
  31. doi Characterisation of monotreme caseins reveals lineage-specific expansion of an ancestral casein locus in mammals
    Christophe M Lefèvre
    Institute for Technology Research and Innovation, Deakin University, Waurn Ponds, VIC 3217, Australia
    Reprod Fertil Dev 21:1015-27. 2009
    ..cDNA sequencing approach we characterised milk-protein sequences from two monotreme species, platypus (Ornithorhynchus anatinus) and echidna (Tachyglossus aculeatus) and found a full set of caseins and casein variants...
  32. ncbi The region homologous to the X-chromosome inactivation centre has been disrupted in marsupial and monotreme mammals
    Timothy A Hore
    ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia
    Chromosome Res 15:147-61. 2007
    ..We found that these genes map to two distant locations on the opossum X, and also to different locations on a platypus autosome...
  33. ncbi Possible differences in pathogenicity between cane toad-, frog- and platypus-derived isolates of Mucor amphibiorum, and a platypus-derived isolate of Mucor circinelloides
    N J Stewart
    School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
    Med Mycol 43:127-32. 2005
    Platypuses (Ornithorhynchus anatinus) in the north of the island state of Tasmania, Australia, suffer from a serious disease called ulcerative mycosis, which is responsible for high morbidity and, presumably, mortality rates in areas ..
  34. doi Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed platypus, Ornithorhynchus anatinus
    M Vernersson
    Department of Cell and Molecular Biology, University of Uppsala, The Biomedical Center, Husargatan 3, Box 596, S 751 24 Uppsala, Sweden
    Mol Immunol 47:785-91. 2010
    ..IgA isotypes during vertebrate evolution we have studied the immunoglobulin repertoire of a model monotreme, the platypus. Two highly divergent IgA-like isotypes (IgA1 and IgA2) were identified and their primary structures were ..
  35. ncbi Photic and circadian regulations of melatonin rhythms in fishes
    M Iigo
    Department of Anatomy, St Marianna University School of Medicine, Kawasaki, Miyamae, Japan
    Biol Signals 6:225-32. 1997
    ..when ocular melatonin rhythms were compared in two cyprinids, the ugui Tribolodon hakonensis and the oikawa Zacco platypus occupying different ecological niches, ocular melatonin contents exhibited daily variations, with higher values ..
  36. ncbi The anterior olfactory nucleus and piriform cortex of the echidna and platypus
    Ken W S Ashwell
    Department of Anatomy, School of Medical Sciences, The University of New South Wales, New South Wales, Sydney, Australia
    Brain Behav Evol 67:203-27. 2006
    ..cyto- and chemoarchitecture of the anterior olfactory nucleus and piriform cortex of the short-beaked echidna and platypus were studied to determine: (1) if these areas contain chemically distinct subdivisions, and (2) if the ..
  37. pmc Body temperature-related structural transitions of monotremal and human hemoglobin
    I Digel
    Department of Cellular Engineering, University of Applied Sciences Aachen, 52428 Juelich, Germany
    Biophys J 91:3014-21. 2006
    In this study, temperature-related structural changes were investigated in human, duck-billed platypus (Ornithorhynchus anatinus, body temperature T(b) = 31-33 degrees C), and echidna (Tachyglossus aculeatus, body temperature T(b) = 32-33 ..
  38. pmc Phylogenetic origins of early alterations in brain region proportions
    Christine J Charvet
    Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, Calif 92687 4550, USA
    Brain Behav Evol 75:104-10. 2010
    ..The presumptive tectum of the platypus is unusually small...
  39. doi The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms
    Bryan G Fry
    Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne 3010 Australia
    Annu Rev Genomics Hum Genet 10:483-511. 2009
    ..animals, including centipedes, cephalopods, cone snails, fish, insects (several independent venom systems), platypus, scorpions, shrews, spiders, toxicoferan reptiles (lizards and snakes), and sea anemones...
  40. ncbi Cyto- and chemoarchitecture of the cerebellum of the short-beaked echidna (Tachyglossus aculeatus)
    K W S Ashwell
    Department of Anatomy, School of Medical Sciences, The University of New South Wales, Sydney, Australia
    Brain Behav Evol 70:71-89. 2007
    The monotremes (echidnas and platypus) have been claimed by some authors to show 'avian' or 'reptilian' features in the gross morphology and microscopic anatomy of the cerebellum...
  41. ncbi Lactose synthesis in a monotreme, the echidna (Tachyglossus aculeatus): isolation and amino acid sequence of echidna alpha-lactalbumin
    M Messer
    Department of Biochemistry, University of Sydney, N S W, Australia
    Comp Biochem Physiol B Biochem Mol Biol 118:403-10. 1997
    ..Its amino acid sequence is more similar to that of another monotreme, the platypus (Ornithorhynchus anatinus), than to the sequences of eutherian or marsupial alpha-lactalbumins...
  42. ncbi Description of a cranial endocast from a fossil platypus, Obdurodon dicksoni (Monotremata, Ornithorhynchidae), and the relevance of endocranial characters to monotreme monophyly
    Thomas E Macrini
    Jackson School of Geosciences and University of Texas High Resolution X ray Computed Tomography Facility, University of Texas at Austin, 78712, USA
    J Morphol 267:1000-15. 2006
    ..with reference to endocasts extracted from skulls of the three species of extant monotremes, particularly Ornithorhynchus anatinus, the duckbill platypus...
  43. ncbi Molecular phylogeny and evolution of the neurotrophins from monotremes and marsupials
    K Kullander
    Department of Developmental Neuroscience, Box 587, Biomedical Center, Uppsala University, S 751 23 Uppsala, Sweden
    J Mol Evol 45:311-21. 1997
    ..PCR was used to amplify fragments encoding parts of the neurotrophin genes from echidna, platypus, and eight marsupials from four different orders...
  44. ncbi The distribution of 5-hydroxytryptamine in the gastrointestinal tract of reptiles, birds and a prototherian mammal. An immunohistochemical study
    S Adamson
    Department of Zoology, University of Melbourne, Parkville, Australia
    Cell Tissue Res 251:633-9. 1988
    ..of 5-hydroxytryptamine in the gut of several species of birds and reptiles, and of a prototherian mammal, the platypus, was studied using a monoclonal antibody...
  45. doi Serological survey for evidence of Leptospira interrogans in free-living platypuses (Ornithorhynchus anatinus)
    L Loewenstein
    Faculty of Veterinary Science, University of Sydney, Camden, NSW 2570, Australia
    Aust Vet J 86:242-5. 2008
    ..To survey free-living platypuses for evidence of Leptospira interrogans...
  46. ncbi Parathyroids and ultimobranchial bodies in monotremes
    J I Haynes
    Department of Anatomical Sciences, University of Adelaide, Australia
    Anat Rec 254:269-80. 1999
    ..and ultimobranchial bodies in the primitive mammals, the echidna (Tachyglossus aculeatus) and platypus (Ornithorhynchus anatinus)...
  47. ncbi "Intermediate zone" of mammalian spleens: light and electron microscopic study of three primitive mammalian species (platypus, shrew, and mole) with special reference to intrasplenic arteriovenous communication
    Y Tanaka
    Department of Clinical Pathology, Ohme Municipal General Hospital, Tokyo, Japan
    Am J Anat 187:313-37. 1990
    The intermediate zone (IZ) of nonperfused and perfused spleens in three species of primitive mammals (shrew, mole, platypus) was studied morphologically...
  48. ncbi Biomechanics and energetics in aquatic and semiaquatic mammals: platypus to whale
    F E Fish
    Department of Biology, West Chester University, West Chester, PA 19383, USA
    Physiol Biochem Zool 73:683-98. 2000
    ..It is these intermediate animals that indicate which potential selection factors and mechanical constraints may have directed the evolution of more derived aquatic forms...
  49. doi Monotreme ossification sequences and the riddle of mammalian skeletal development
    Vera Weisbecker
    Earth Sciences, University of Cambridge, Downing St CB2 3EQ, Cambridge, United Kingdom
    Evolution 65:1323-35. 2011
    ..Here, I present the first postcranial ossification sequences of the monotreme echidna and platypus, and compare these with published data from other mammals and amniotes...
  50. pmc Long conserved fragments upstream of Mammalian polyadenylation sites
    Eric S Ho
    Department of Molecular Biology and Biochemistry, Nelson Laboratories, Rutgers University, Piscataway, New Jersey, USA
    Genome Biol Evol 3:654-66. 2011
    ..When an even more remote transitional mammal, platypus, was included, still over a thousand CFs were found in the proximity of the PAS...
  51. ncbi The distribution and morphological characteristics of catecholaminergic cells in the brain of monotremes as revealed by tyrosine hydroxylase immunohistochemistry
    P R Manger
    Department of Psychiatry, University of California, Los Angeles, Neurobiology Research 151A3, Sepulveda VAMC, North Hills, Calif, USA
    Brain Behav Evol 60:298-314. 2002
    ..cellular morphology of catecholaminergic neurons in the CNS of two species of monotreme, the platypus (Ornithorhynchus anatinus) and the short-beaked echidna (Tachyglossus aculeatus)...
  52. doi Platypus chain reaction: directional and ordered meiotic pairing of the multiple sex chromosome chain in Ornithorhynchus anatinus
    Tasman Daish
    Discipline of Genetics, School of Molecular and Biomedical Science, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia
    Reprod Fertil Dev 21:976-84. 2009
    ..unique animals with an unusually complex sex chromosome system that is composed of ten chromosomes in platypus and nine in echidna. These chromosomes are alternately linked (X1Y1, X2Y2, .....
  53. ncbi Pika and vole mitochondrial genomes increase support for both rodent monophyly and glires
    Yu Hsin Lin
    Allan Wilson Centre for Molecular Ecology and Evolution, Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
    Gene 294:119-29. 2002
    ..However, when this tree is rooted with marsupials plus platypus, the outgroup often joins the lineage leading to the three murid rodents, so the rodents are no longer ..
  54. ncbi Tox-Prot, the toxin protein annotation program of the Swiss-Prot protein knowledgebase
    Florence Jungo
    Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneve 4, Switzerland
    Toxicon 45:293-301. 2005
    ..such as snakes, scorpions, spiders, jellyfish, insects, cone snails, sea anemones, lizards, some fish, and platypus are equipped with a specialized organ to inject venom in their prey...
  55. ncbi Cyto- and chemoarchitecture of the amygdala of a monotreme, Tachyglossus aculeatus (the short-beaked echidna)
    Ken W S Ashwell
    Department of Anatomy, School of Medical Sciences, The University of New South Wales, Australia
    J Chem Neuroanat 30:82-104. 2005
    ..Volumetric analysis indicated that the temporal amygdala in both the platypus and echidna is small compared to the same structure in both insectivores and primates, with the central and ..
  56. pmc Molecular evolution of dentin phosphoprotein among toothed and toothless animals
    Dianalee A McKnight
    Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda MD 20892, USA
    BMC Evol Biol 9:299. 2009
    ....
  57. doi Marsupial and monotreme genomes
    E Koina
    Comparative Genomics Group and ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, Australia
    Genome Dyn 2:111-22. 2006
    ..Marsupials (e.g. kangaroo, opossum) and monotremes (e.g. platypus) differ from placental mammals in many characteristics, particularly reproduction...
  58. doi Evolution of an X-linked primate-specific micro RNA cluster
    Jingjing Li
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Mol Biol Evol 27:671-83. 2010
    ..species but unidentifiable in other mammalian species (including mouse, rat, cat, dog, horse, cow, opossum, and platypus), suggesting that the formation of this cluster was after the primate-rodent split but before the emergence of ..
  59. ncbi DMRT gene cluster analysis in the platypus: new insights into genomic organization and regulatory regions
    Nisrine El-Mogharbel
    Comparative Genomics Group, Research School of Biological Sciences, Australian National University, P O Box 475, Canberra, ACT 2601, Australia
    Genomics 89:10-21. 2007
    We isolated and characterized a cluster of platypus DMRT genes and compared their arrangement, location, and sequence across vertebrates. The DMRT gene cluster on human 9p24...
  60. pmc Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting
    Shunsuke Suzuki
    Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS Genet 3:e55. 2007
    ..marsupial tammar wallaby (Macropus eugenii), but not in a prototherian mammal, the egg-laying platypus (Ornithorhynchus anatinus), suggesting its close relationship to the origin of placentation in therian mammals...
  61. ncbi Uncertain breeding: a short history of reproduction in monotremes
    P Temple-Smith
    Department of Conservation and Research, Zoological Parks and Gardens Board, Parkville, Victoria, Australia
    Reprod Fertil Dev 13:487-97. 2001
    ..significant gains in knowledge have ensued; for example a more accurate estimate of the gestation period of the platypus and the incubation period for the Tachyglossus egg...
  62. doi Cone visual pigments of monotremes: filling the phylogenetic gap
    Matthew J Wakefield
    ARC, Centre for Kangaroo Genomics, Bioinformatics, The Walter and Eliza Hall Institute, Parkville, Australia
    Vis Neurosci 25:257-64. 2008
    ..the sequence and genomic organization of the genes encoding the cone visual pigment of the platypus (Ornithorhynchus anatinus) and the echidna (Tachyglossus aculeatus), and inferred their spectral properties and evolutionary ..
  63. pmc Fishborne trematode metacercariae in freshwater fish from Guangxi Zhuang Autonomous Region, China
    Woon Mok Sohn
    Department of Parasitology and Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea
    Korean J Parasitol 47:249-57. 2009
    ..Total 13 C. sinensis metacercariae were found in 3 out of 10 Hemibarbus maculatus from Yangshuo. All 7 Zacco platypus from Yangshuo were infected with 8-112 Echinochasmus perfoliatus metacercariae. In fish from Binyang-xian, H...
  64. ncbi Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials
    Hajime J Yuasa
    Molecular Immunopathology Unit, Discipline of Pathology, School of Medical Sciences, University of Sydney, NSW 2006, Australia
    Comp Biochem Physiol B Biochem Mol Biol 153:137-44. 2009
    ..In this study, we isolated both IDO1 and IDO2 cDNA from a monotreme, the platypus (Ornithorhynchus anatinus), and a marsupial, the gray short-tailed opossum (Monodelphis domestica)...
  65. doi Lung development of monotremes: evidence for the mammalian morphotype
    Kirsten Ferner
    Institute of Systematic Zoology, Museum of Natural History, Berlin, Germany
    Anat Rec (Hoboken) 292:190-201. 2009
    ..The lung development in monotremes (Ornithorhynchus anatinus, Tachyglossus aculeatus), in one marsupial (Monodelphis domestica), and one altricial eutherian (Suncus ..
  66. ncbi Evolution of mammalian X-chromosome inactivation: sex chromatin in monotremes and marsupials
    L M McKay
    Department of Genetics and Human Variation, La Trobe University, Bundoora, Vic
    Aust J Biol Sci 40:397-404. 1987
    ..chromatin body in these same tissues in marsupials (brush-tail possum, Trichosurus vulpecula) and monotremes (platypus, Ornithorynchus anatinus), using classical histological techniques...
  67. ncbi Drought until death do us part: a case study of the desiccation-tolerance of a tropical moist forest seedling-tree, Licania platypus (Hemsl.) Fritsch
    Melvin T Tyree
    USDA Forest Service, PO Box 968, Burlington, VT 05402, USA
    J Exp Bot 53:2239-47. 2002
    Studies of the desiccation tolerance of 15-month-old Licania platypus (Hemsl.) Fritsch seedlings were performed on potted plants...
  68. pmc Receptors in the bill of the platypus
    J E Gregory
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    J Physiol 400:349-66. 1988
    1. Afferent responses were recorded from filaments of the trigeminal nerve in each of two platypuses (Ornithorhynchus anatinus) anaesthetized with alpha-chloralose...
  69. doi Comparative retinal morphology of the platypus
    Caroline J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Morphol 272:949-57. 2011
    The purpose of this study is to identify evolutionary origin and fate of anatomic features of the duck-billed platypus eye...
  70. pmc Higher-order genome organization in platypus and chicken sperm and repositioning of sex chromosomes during mammalian evolution
    Enkhjargal Tsend-Ayush
    School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA, Australia
    Chromosoma 118:53-69. 2009
    ..Monotremes (platypus and echidnas) are the most basal group of living mammals...
  71. ncbi In the platypus a meiotic chain of ten sex chromosomes shares genes with the bird Z and mammal X chromosomes
    Frank Grützner
    Research School of Biological Sciences, Australian National University, GPO Box 475, Canberra, Australian Capital Territory 2601, Australia
    Nature 432:913-7. 2004
    Two centuries after the duck-billed platypus was discovered, monotreme chromosome systems remain deeply puzzling...
  72. ncbi Identification and structural analysis of four serine proteases in a monotreme, the platypus, Ornithorhynchus anatinus
    M Poorafshar
    Department of Cell and Molecular Biology, University of Uppsala, Biomedical Center, Sweden
    Immunogenetics 52:19-28. 2000
    ..here the primary structure of four serine proteases expressed in the spleen of a monotreme, the platypus, Ornithorhynchus anatinus. Partial cDNA clones for four serine proteases were isolated by a PCR-based strategy...
  73. pmc Defensins and the convergent evolution of platypus and reptile venom genes
    Camilla M Whittington
    Faculty of Veterinary Science, University of Sydney, Sydney, New South Wales 2006, Australia
    Genome Res 18:986-94. 2008
    When the platypus (Ornithorhynchus anatinus) was first discovered, it was thought to be a taxidermist's hoax, as it has a blend of mammalian and reptilian features...
  74. ncbi Serological responses against the pathogenic dimorphic fungus Mucor amphibiorum in populations of platypus (Ornithorhynchus anatinus) with and without ulcerative mycotic dermatitis
    R J Whittington
    Faculty of Veterinary Science, University of Sydney, Private Mail Bag 3, NSW 2570, Camden, Australia
    Vet Microbiol 87:59-71. 2002
    ..Mucor amphibiorum, a dimorphic fungus, causes ulcerative dermatitis and systemic infections in the platypus Ornithorhynchus anatinus in some river systems in Tasmania but apparently not in other regions of Australia...
  75. doi Low incidence of N-glycolylneuraminic acid in birds and reptiles and its absence in the platypus
    Roland Schauer
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    Carbohydr Res 344:1494-500. 2009
    The sialic acids of the platypus, birds, and reptiles were investigated with regard to the occurrence of N-glycolylneuraminic (Neu5Gc) acid...
  76. ncbi Mammalian l-to-d-amino-acid-residue isomerase from platypus venom
    Allan M Torres
    School of Molecular and Microbial Biosciences, University of Sydney, Building G08, Sydney, NSW 2006, Australia
    FEBS Lett 580:1587-91. 2006
    ..polypeptides, defensin-like peptide (DLP)-2 and Ornithorhyncus venom C-type natriuretic peptide (OvCNP)b, in platypus venom suggested the existence of a mammalian d-amino-acid-residue isomerase(s) responsible for the modification ..
  77. pmc D-amino acid residue in a defensin-like peptide from platypus venom: effect on structure and chromatographic properties
    Allan M Torres
    School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
    Biochem J 391:215-20. 2005
    The recent discovery that the natriuretic peptide OvCNPb (Ornithorhynchus venom C-type natriuretic peptide B) from platypus (Ornithorynchus anatinus) venom contains a D-amino acid residue suggested that other D-amino-acid-containing ..
  78. ncbi Potential impact of global warming on deciduous oak dieback caused by ambrosia fungus Raffaelea sp. carried by ambrosia beetle Platypus quercivorus (Coleoptera: Platypodidae) in Japan
    N Kamata
    Department of Biology, Faculty of Sciences Kanazawa University, Kanazawa, Ishikawa, 920 1192, Japan
    Bull Entomol Res 92:119-26. 2002
    ..The symbiotic ambrosia fungus Raffaelea sp. is the causal agent of oak dieback, and is vectored by Platypus quercivorus (Murayama). This is the first example of an ambrosia beetle fungus that kills vigorous trees...
  79. pmc Donkey orchid symptomless virus: a viral 'platypus' from Australian terrestrial orchids
    Stephen J Wylie
    Australian Plant Virology Laboratory, Western Australian State Agricultural Biotechnology Centre, School of Veterinary and Life Sciences, Murdoch University, Perth, Australia
    PLoS ONE 8:e79587. 2013
    ..The MP shares an evolutionary history with MPs of dianthoviruses, but the other putative proteins are distant from plant viruses. DOSV is not readily classified in current lower order virus taxa. ..
  80. ncbi The major histocompatibility complex in monotremes: an analysis of the evolution of Mhc class I genes across all three mammalian subclasses
    Katarzyna B Miska
    Department of Biology, University of New Mexico, Albuquerque 87131, USA
    Immunogenetics 54:381-93. 2002
    ..major histocompatibility complex class-I ( Mhc-I) genes from two species of monotremes: the duck-billed platypus and the short-beaked echidna...
  81. ncbi Sequence and functional conservation of the intergenic region between the head-to-head genes encoding the small heat shock proteins alphaB-crystallin and HspB2 in the mammalian lineage
    Linda Doerwald
    Department of Biochemistry, Faculty of Science, University of Nijmegen, Nijmegen, The Netherlands
    J Mol Evol 59:674-86. 2004
    ..The intergenic distance between the genes for these two proteins in mammals ranges from 645 bp (platypus) to 1069 bp (opossum), with an average of about 900 bp; in chicken the distance was the same as in duck (1.6 kb)...
  82. doi Multi-level stressor analysis from the DNA/biochemical level to community levels in an urban stream and integrative health response (IHR) assessments
    Jae Hoon Lee
    Department of Biological Science, College of Biological Sciences and Biotechnology, Chungnam National University, Daejeon, Korea
    J Environ Sci Health A Tox Hazard Subst Environ Eng 48:211-22. 2013
    ..e., liver, kidney, and gill, at the S (i) site. Population-level analysis using the sentinel species Zacco platypus showed that the regression coefficient (b) was 3.012 for the S (i) site and 2...
  83. pmc Identification of two distinct genes at the vertebrate TRPC2 locus and their characterisation in a marsupial and a monotreme
    Stephen Frankenberg
    Department of Zoology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    BMC Mol Biol 12:39. 2011
    ..Both VRs have a common receptor activation cascade involving transient receptor potential channel, subfamily C, member 2 (TRPC2)...
  84. doi Integrative assessment of biomarker responses in pale chub (Zacco platypus) exposed to copper and benzo[a]pyrene
    Woo Keun Kim
    Ecotoxicology Research Center, Korea Institute of Toxicology, Daejeon 305 343, Republic of Korea
    Ecotoxicol Environ Saf 92:71-8. 2013
    ..25, 5, and 20μg/L) and benzo[a]pyrene (BaP: 0.5, 5, and 50μg/L) induced in the freshwater pale chub Zacco platypus. Except for the kidney tissues when exposed to 20μg Cu/L, no significant differences were observed at the ..
  85. pmc Molecular evolution of the non-coding eosinophil granule ontogeny transcript
    Dominic Rose
    Bioinformatics Group, Department of Computer Science, University of Freiburg Freiburg, Germany
    Front Genet 2:69. 2011
    ..carnivores, afrotherians, and xenarthrans, as well as putative candidates from basal amniotes, such as opossum or platypus. We investigate the EGOT gene phylogeny, analyze patterns of sequence conservation, and the evolutionary ..
  86. doi Detection of platypus-type L/D-peptide isomerase activity in aqueous extracts of papaya fruit
    Kensuke Arakawa
    School of Molecular Bioscience, University of Sydney, Building G08, Sydney, NSW 2006, Australia
    Biotechnol Lett 34:1659-65. 2012
    ..This is the first report of peptide isomerase activity in a plant and suggests that perhaps every living organism may have some peptide isomerase activity...
  87. doi Development of the cerebellum in the platypus (Ornithorhynchus anatinus) and short-beaked echidna (Tachyglossus aculeatus)
    Ken W S Ashwell
    Department of Anatomy, School of Medical Sciences, The University of New South Wales, Sydney, Australia
    Brain Behav Evol 79:237-51. 2012
    ..Those activities are most likely controlled by the spinal cord and medullary reticular formation circuitry...
  88. doi Molecular evolution of matrix metalloproteinase 20
    Kazuhiko Kawasaki
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Eur J Oral Sci 119:247-53. 2011
    ..Nevertheless, for unknown reasons, we failed to identify MMP20 in the platypus genome. In the opossum, lizard, and frog genomes, MMP20 was found clustered with MMP13...
  89. doi The Prime Minister and the platypus: A paradox goes to war
    Natalie Lawrence
    St John s College, Cambridge University, Cambridge CB2 1TP, UK
    Stud Hist Philos Biol Biomed Sci 43:290-7. 2012
    ..1943, in the midst of the Second World War, Prime Minister Winston Churchill demanded that a live duck-billed platypus be sent from Australia to Britain. A vigorous male was shipped off but died shortly before arrival in Britain...
  90. pmc Human microRNAs originated from two periods at accelerated rates in mammalian evolution
    Hisakazu Iwama
    Life Science Research Center, Kagawa University, Kita gun, Kagawa, Japan
    Mol Biol Evol 30:613-26. 2013
    ..periods during which each of 1,433 present human miRNA genes originated within 15 periods, from human to platypus-human common ancestral branch and a class "conserved beyond theria," primarily using multiple genome alignments ..
  91. pmc A porcine gene, PBK, differentially expressed in the longissimus muscle from Meishan and Large White pig
    Liu Yonggang
    College of Animal Science and Technology, Yunnan Agricultural University, Kunming China
    Genet Mol Biol 32:771-5. 2009
    ..horse, cattle, human, chimpanzee, crab-eating macaque, rhesus monkey, rat, mouse, gray short-tailed opossum and platypus, so it can be defined as the porcine PBK gene. This gene was finally assigned GeneID:100141310...
  92. pmc Identification of three prominin homologs and characterization of their messenger RNA expression in Xenopus laevis tissues
    Zhou Han
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Vis 17:1381-96. 2011
    ..In this study, we identified three prominin homologs in Xenopus laevis, a model animal widely used in vision research, and characterized their messenger RNA (mRNA) expression in selected tissues of this frog...
  93. doi Regulation of expression of zebrafish (Danio rerio) insulin-like growth factor 2 receptor: implications for evolution at the IGF2R locus
    Matina Tsalavouta
    School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland
    Evol Dev 11:546-58. 2009
    ..AUGs (uAUGs) are a feature of IGF2R genes in several other vertebrates, including Xiphophorus, Xenopus, chicken, platypus, and opossum, but not in eutherian mammals...
  94. doi Eggs, embryos and the evolution of imprinting: insights from the platypus genome
    Marilyn B Renfree
    ARC Centre of Excellence for Kangaroo Genomics, Australia
    Reprod Fertil Dev 21:935-42. 2009
    ..The recent release of the platypus genome sequence has provided the first opportunity to make comparisons between prototherian (monotreme, which ..
  95. ncbi Mechanism of Cd(II) adsorption by macrofungus Pleurotus platypus
    R Vimala
    School of Biosciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India
    J Environ Sci (China) 23:288-93. 2011
    The mechanism of Cd(II) uptake by the dead biomass of macrofungus Pleurotus platypus was investigated using different chemical and instrumental techniques...
  96. doi Monotreme sex chromosomes--implications for the evolution of amniote sex chromosomes
    Paul D Waters
    Comparative Genomics Group, Research School of Biological Sciences, School of Biology, The Australian National University, GPO Box 475, Canberra, ACT 2601, Australia
    Reprod Fertil Dev 21:943-51. 2009
    ..In particular, the recent completion of the platypus genome sequence has completely changed our understanding of when the therian mammal X and Y chromosomes first ..
  97. pmc The platypus is not a rodent: DNA hybridization, amniote phylogeny and the palimpsest theory
    J A Kirsch
    University of Wisconsin Zoological Museum, Madison, WI 53706, USA
    Philos Trans R Soc Lond B Biol Sci 353:1221-37. 1998
    ....
  98. pmc Genetic structure of the oak wilt vector beetle Platypus quercivorus: inferences toward the process of damaged area expansion
    Etsuko Shoda-Kagaya
    Forestry and Forest Products Research Institute, Tsukuba, Japan
    BMC Ecol 10:21. 2010
    The ambrosia beetle, Platypus quercivorus, is the vector of oak wilt, one of the most serious forest diseases in Japan...
  99. doi Fungus symbionts colonizing the galleries of the ambrosia beetle Platypus quercivorus
    Rikiya Endoh
    Laboratory of Environmental Mycoscience, Division of Environmental Science and Technology, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto, 606 8502, Japan
    Microb Ecol 62:106-20. 2011
    Isolations were made to determine the fungal symbionts colonizing Platypus quercivorus beetle galleries of dead or dying Quercus laurifolia, Castanopsis cuspidata, Quercus serrata, Quercus crispula, and Quercus robur...
  100. doi A newly classified vertebrate calpain protease, directly ancestral to CAPN1 and 2, episodically evolved a restricted physiological function in placental mammals
    Daniel J Macqueen
    Physiological and Evolutionary Genomics Laboratory, School of Biology, Scottish Oceans Institute, University of St Andrews, St Andrews, Fife, United Kingdom
    Mol Biol Evol 27:1886-902. 2010
    ..an approximately 7-fold elevation in d(N)/d(S) is evident along the CAPN11 branch splitting eutherians from platypus, paralleled by a shift to "testis-specific" gene regulation...
  101. doi Mammalian peptide isomerase: platypus-type activity is present in mouse heart
    Jennifer M S Koh
    School of Molecular Biosciences, Building G08, University of Sydney, NSW 2006, Australia
    Chem Biodivers 7:1603-11. 2010
    Male platypus (Ornithorhynchus anatinus) venom has a peptidyl aminoacyl L/D-isomerase (hereafter called peptide isomerase) that converts the second amino acid residue in from the N-terminus from the L- to the D-form, and vice versa...

Research Grants90

  1. Multiplexed Personal Monitoring of Airborne Toxins
    BHARAT ACHARYA; Fiscal Year: 2007
    ..detected from a vapor phase by utilizing chemically functionalized, nanostructured surfaces and liquid crystals (Platypus( technology). What is needed, however, is a monitor that simultaneously measures exposure to multiple compounds...
  2. Biophotonics for Detection of West Nile Virus
    Barbara Israel; Fiscal Year: 2002
    b>Platypus technology is a radically different approach to the detection and simultaneous identification of viruses...
  3. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2007
    ..BAC) libraries from the imprinted opossum (Didelphus virginiana) and the non-imprinted platypus (Ornithorhynchus anatinus) to examine imprinted domains containing genes involved in cancer that are regulated by three different ..
  4. Obliquely deposited substrates for detection of Ras
    Barbara Israel; Fiscal Year: 2003
    ..b>Platypus technology is a novel, broadly applicable platform nanotechnology based on the sensitivity of liquid crystals to ..
  5. Personal Dosimeter for OPs Using Nano-structured Surface
    Barbara Israel; Fiscal Year: 2006
    ..These data strongly support the feasibility of Platypus TM technology as the basis of small, inexpensive, rugged passive monitors suitable for measuring cumulative ..
  6. Biophotonic detection of WNV Abs from Multiple Species
    RENEE HERBER; Fiscal Year: 2007
    This Phase 2 proposal will further the development of a fundamentally new, broadly applicable technology (Platypus technology) for the rapid, label-free detection of proteins...
  7. Liquid crystal based enzyme activity assay
    Barbara Israel; Fiscal Year: 2005
    ..b>Platypus TM technology can be the foundation for such assays to accelerate basic research, drug discovery, evaluation of ..
  8. Evolution of sodium channel genes
    Harold Zakon; Fiscal Year: 2009
    ..This work will be medically important to understand the function of sodium channels, a clinically important family of ion channels. ..
  9. HORMONAL MODULATION OF A COMMUNICATION SIGNAL
    Harold Zakon; Fiscal Year: 2007
    ..Specific aim 4 is to study differential expression and hormonal regulation of two splice forms of a Na+ channel beta subunit, and how the different splice forms might influence the inactivation rate of the Na+ current. ..
  10. Transformation by Reticuloendotheliosis Virus
    HENRY BOSE; Fiscal Year: 2007
    ..Proposed experiments will investigate the regulation of the TERT promoter by v-Rel, define the telomerase activity encoded by TERT splice variants, and determine the mechanism by which v-Rel suppresses the alternative splicing of TERT. ..
  11. HORMONAL MODULATION OF A COMMUNICATION SIGNAL
    Harold Zakon; Fiscal Year: 2003
    ..Understanding how ion channels function and are regulated is critical to our fundamental knowledge of excitable cells, especially as malfunctions of ion channels are increasingly recognized in a variety of diseases. ..
  12. CELLULAR BASIS FOR STEROID ACTION IN AN EXCITABLE CELL
    Harold Zakon; Fiscal Year: 1991
    ..The other, more general, point is that this work will illuminate the fundamental question of how excitability of an excitable membrane may be regulated...
  13. Control of Mammalian Meiotic Recombination
    Terry Ashley; Fiscal Year: 2007
    ..In addition, we will examine the effects of mutations in genes likely to be involved in control of frequency and distribution of recombination. ..
  14. "Gdf6 gene expression and evolution in vertebrates"
    Douglas Mortlock; Fiscal Year: 2009
    ..These experiments will provide extensive insights into the conservation of this important signaling pathway gene in different animal models and the role genomic sequences play in normal skeletal patterning. ..
  15. STRUCTURAL STUDIES ON FIBRINOGEN AND FIBRIN
    Russell Doolittle; Fiscal Year: 2003
    ..Combined with the full structures of the native molecules at high resolution, these results should dispel much of the mystery of fibrin formation. ..
  16. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2007
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
  17. Characterization of the flexible portions of fibrinogen
    Russell Doolittle; Fiscal Year: 2007
    ..These studies are aimed at determining the degree of specificity involved in the assembly of fibrin units and protofibrils as well as the relative locations of the regions involved. ..
  18. MALE STERILITY AND MEIOTIC CHECKPOINT
    Terry Ashley; Fiscal Year: 2004
    ..Our results will lead to a better understanding of some of the underlying causes of male sterility and could also lead to new insights into development of a male contraceptive. ..
  19. FUNCTION AND CONSERVATION IN GLOBIN LOCUS CONTROL REGION
    Ross Hardison; Fiscal Year: 2001
    ..5 and isolate the binding proteins. ..
  20. The Role of Sedlin in Maintaining Cartilage Integrity
    Douglas Mortlock; Fiscal Year: 2005
    ..Moreover, we anticipate that these studies will yield valuable insight into the role of the sedlin pathway in maintaining cartilage integrity and its derangement in osteoarthritis. ..
  21. ORGANIZATION AND EXPRESSION OF GLOBIN GENE LOCI
    Ross Hardison; Fiscal Year: 1991
    ..6) The sequence of the entire rabbit Beta-like globin gene cluster (44 kb) will be completed and compared to the homologous region in humans and mice...