western clawed frog


Alias: Silurana tropicalis, Xenopus tropicalis, Xenopus (Silurana) tropicalis, Silurana tropicalis Gray, 1864, Xenopus laevis tropicalis, Xenopus tropicalis (Gray, 1864)

Top Publications

  1. Degot S, Le Hir H, Alpy F, Kedinger V, Stoll I, Wendling C, et al. Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module. J Biol Chem. 2004;279:33702-15 pubmed publisher
    ..Altogether our data demonstrate that MLN51 associates with EJC in the nucleus and remains stably associated with mRNA in the cytoplasm, suggesting that its overexpression might alter mRNA metabolism in cancer...
  2. Monti E, Bassi M, Papini N, Riboni M, Manzoni M, Venerando B, et al. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Biochem J. 2000;349:343-51 pubmed
    ..8. Immunofluorescence staining of the transfected COS7 cells demonstrated the protein's localization in the plasma membrane. ..
  3. Fletcher R, Watson A, Harland R. Expression of Xenopus tropicalis noggin1 and noggin2 in early development: two noggin genes in a tetrapod. Gene Expr Patterns. 2004;5:225-30 pubmed
    We report the identification of two distinct noggin genes in the tetrapod Xenopus tropicalis. Noggin functions to antagonize BMP signaling in many developmental contexts, and much work has explored its role in early vertebrate development...
  4. Howard M, Aggarwal G, Anderson C, Khatri S, Flanigan K, Atkins J. Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codons. EMBO J. 2005;24:1596-607 pubmed
    ..Sequences capable of forming strong RNA structures were also identified 3' adjacent to, or near, selenocysteine-encoding UGA codons in the Sps2, SelH, SelO, and SelT selenoprotein genes. ..
  5. Millery J, Briand L, Bézirard V, Blon F, Fenech C, Richard Parpaillon L, et al. Specific expression of olfactory binding protein in the aerial olfactory cavity of adult and developing Xenopus. Eur J Neurosci. 2005;22:1389-99 pubmed
    ..We therefore purified and cloned OBPs in two Xenopus species. Xenopus laevis OBP (XlaeOBP) and Xenopus tropicalis OBP (XtroOBP) exhibit 158 and 160 amino acids, respectively, sharing 89 residues...
  6. Abu Daya A, Sater A, Wells D, Mohun T, Zimmerman L. Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6. Dev Biol. 2009;336:20-9 pubmed publisher
    ..Forward genetic screens in Xenopus tropicalis have identified more than 80 mutations affecting diverse developmental processes, including cardiac ..
  7. Roth M, Bonev B, Lindsay J, Lea R, Panagiotaki N, Houart C, et al. FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation. Development. 2010;137:1553-62 pubmed publisher
    ..Here, we show that interaction of FoxG1 with TLE2, a Xenopus tropicalis co-repressor of the Groucho/TLE family, is crucial for regulating the early activity of FoxG1...
  8. Giacopuzzi E, Barlati S, Preti A, Venerando B, Monti E, Borsani G, et al. Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops. BMC Biochem. 2011;12:45 pubmed publisher
    ..Giving the peculiar organization of the loop region identified in Gg NEU3, this protein can be considered of particular interest in such evolutionary studies and to get deeper insights in sialidase evolution. ..
  9. Hülsmann B, Labokha A, Gorlich D. The permeability of reconstituted nuclear pores provides direct evidence for the selective phase model. Cell. 2012;150:738-51 pubmed publisher
    ..Our data exclude alternative models that are based solely on an interaction between the FG repeats and NTRs and indicate that the barrier is formed by a sieve-like FG hydrogel...

More Information

Publications202 found, 100 shown here

  1. Knochel S, Dillinger K, Koster M, Knochel W. Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes. Mech Dev. 2001;109:79-82 pubmed
    The Xenopus tropicalis BMP-2 and BMP-4 genes have been cloned and sequenced. A comparison with the corresponding genes from X. laevis reveals that the BMP-4 genes are conserved at a higher extent than the BMP-2 genes...
  2. Reece Hoyes J, Keenan I, Isaacs H. Cloning and expression of the Cdx family from the frog Xenopus tropicalis. Dev Dyn. 2002;223:134-40 pubmed
    ..In this study, we report the cloning of cDNAs from the Cdx genes of the amphibian Xenopus tropicalis. Xenopus tropicalis is a diploid species, related to the commonly used laboratory animal Xenopus laevis, and ..
  3. Monti E, Bassi M, Bresciani R, Civini S, Croci G, Papini N, et al. Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. Genomics. 2004;83:445-53 pubmed
    ..Immunofluorescence staining and Western blot analysis demonstrated the association of NEU4 with the inner cell membranes. ..
  4. Sivak J, Petersen L, Amaya E. FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation. Dev Cell. 2005;8:689-701 pubmed
    ..We identified two genes for each family in Xenopus tropicalis: Xtsprouty1, Xtsprouty2, Xtspred1, and Xtspred2...
  5. Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan S, Handa V, et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature. 2007;445:671-5 pubmed
    ..Active demethylation occurs by DNA repair and Gadd45a interacts with and requires the DNA repair endonuclease XPG. We conclude that Gadd45a relieves epigenetic gene silencing by promoting DNA repair, which erases methylation marks. ..
  6. Fierro A, Thuret R, Coen L, Perron M, Demeneix B, Wegnez M, et al. Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysis. BMC Genomics. 2007;8:118 pubmed
    The western African clawed frog Xenopus tropicalis is an anuran amphibian species now used as model in vertebrate comparative genomics. It provides the same advantages as Xenopus laevis but is diploid and has a smaller genome of 1.7 Gbp...
  7. Huang J, Dorey K, Ishibashi S, Amaya E. BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo. BMC Dev Biol. 2007;7:59 pubmed
  8. Manzoni M, Colombi P, Papini N, Rubaga L, Tiso N, Preti A, et al. Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio). Biochem J. 2007;408:395-406 pubmed publisher
    ..Overall, the redundancy of sialidases together with their expression profile and their activity exerted on gangliosides of living cells indicate the biological relevance of this class of enzymes in zebrafish...
  9. Burnett L, Boyles S, Spencer C, Bieber A, Chandler D. Xenopus tropicalis allurin: expression, purification, and characterization of a sperm chemoattractant that exhibits cross-species activity. Dev Biol. 2008;316:408-16 pubmed publisher
    ..Here we report identification, purification, and characterization of Xenopus tropicalis (Xt) allurin, a homologous protein in X. tropicalis...
  10. Bilesimo P, Jolivet P, Alfama G, Buisine N, Le Mevel S, Havis E, et al. Specific histone lysine 4 methylation patterns define TR-binding capacity and differentiate direct T3 responses. Mol Endocrinol. 2011;25:225-37 pubmed publisher
    ..Reverse transcription-real-time quantitative PCR analysis on Xenopus tropicalis tadpole brain and tail fin showed differences in expression levels in premetamorphic tadpoles (lower for TH/..
  11. Fakhro K, Choi M, Ware S, Belmont J, Towbin J, Lifton R, et al. Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning. Proc Natl Acad Sci U S A. 2011;108:2915-20 pubmed publisher
    ..These effects were specific, because 0 of 13 control genes from rare Htx or control copy number variations produced significant LR abnormalities (P = 0.001). These findings identify genes not previously implicated in LR patterning. ..
  12. Yamaguchi Y, Hayashi A, Campagnoni C, Kimura A, Inuzuka T, Baba H. L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough. J Biol Chem. 2012;287:17765-76 pubmed publisher
    ..Since this is the first finding of stop codon readthrough in a common mammalian protein, detailed analysis of L-MPZ expression will help to understand the mechanism of stop codon readthrough in mammals. ..
  13. Faas L, Warrander F, Maguire R, Ramsbottom S, Quinn D, Genever P, et al. Lin28 proteins are required for germ layer specification in Xenopus. Development. 2013;140:976-86 pubmed publisher
    ..They have since been implicated as regulators of pluripotency in mammalian stem cells in culture. Using Xenopus tropicalis, we have undertaken the first analysis of the effects on the early development of a vertebrate embryo ..
  14. Carruthers S, Mason J, Papalopulu N. Depletion of the cell-cycle inhibitor p27(Xic1) impairs neuronal differentiation and increases the number of ElrC(+) progenitor cells in Xenopus tropicalis. Mech Dev. 2003;120:607-16 pubmed
    ..For such knockdown studies, Xenopus tropicalis is a better model system than Xenopus laevis, since it has a diploid genome. Indeed, while X...
  15. Illes J, Winterbottom E, Isaacs H. Cloning and expression analysis of the anterior parahox genes, Gsh1 and Gsh2 from Xenopus tropicalis. Dev Dyn. 2009;238:194-203 pubmed publisher
    ..We report the cloning of two Gsx genes, Gsh1 and Gsh2, from the frog Xenopus tropicalis. We demonstrate the existence of a single, intact Xenopus ParaHox cluster, containing Gsh1, Pdx, and Cdx2, ..
  16. García Añoveros J, Wiwatpanit T. TRPML2 and mucolipin evolution. Handb Exp Pharmacol. 2014;222:647-58 pubmed publisher
    ..as Mcoln3 in the genomes of most jawed vertebrates (from humans to sharks) with the exception of pigs, Xenopus tropicalis, and ray-finned fishes...
  17. Lang T, Klasson S, Larsson E, Johansson M, Hansson G, Samuelsson T. Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP. Mol Biol Evol. 2016;33:1921-36 pubmed publisher
    ..An exception is the frog Xenopus tropicalis with an expanded repertoire of at least 26 mucins of this type...
  18. Borràs E, Albalat R, Duester G, Parés X, Farrés J. The Xenopus alcohol dehydrogenase gene family: characterization and comparative analysis incorporating amphibian and reptilian genomes. BMC Genomics. 2014;15:216 pubmed publisher
    ..the high complexity of the ADH system in amphibians, with eleven genes, coding for seven enzyme classes in Xenopus tropicalis. Frogs possess the amphibian-specific ADH8 and the novel ADH1-derived forms ADH9 and ADH10...
  19. Ramírez Gordillo D, Powers T, Van Velkinburgh J, Trujillo Provencio C, SCHILKEY F, Serrano E. RNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM(®) genes for hereditary disorders of hearing and balance. BMC Res Notes. 2015;8:691 pubmed publisher
    ..As part of this study we identified candidate scaffold regions of the Xenopus tropicalis genome that can be used to investigate hearing and balance using genetic and informatics procedures that are ..
  20. Chen Q, Ma J, Fan Y, Meng Y, Xu J, Zhou Y, et al. Identification of type I IFN in Chinese giant salamander (Andrias davidianus) and the response to an iridovirus infection. Mol Immunol. 2015;65:350-9 pubmed publisher
    ..gsIFN is 1113 bp and encodes a putative protein of 186 amino acids that has a 43% identity to type I IFN of Xenopus tropicalis. The deduced amino acid sequence has the C-terminal CAWE motif, that is mostly conserved in the higher ..
  21. Wen L, Fu L, Shi Y. Histone methyltransferase Dot1L is a coactivator for thyroid hormone receptor during Xenopus development. FASEB J. 2017;31:4821-4831 pubmed publisher
    ..metamorphosis in two highly related species, the pseudo-tetraploid Xenopus laevis and diploid Xenopus tropicalis, as a model for postembryonic development, a period around birth in mammals that is difficult to study...
  22. Deryusheva S, Gall J. Dual nature of pseudouridylation in U2 snRNA: Pus1p-dependent and Pus1p-independent activities in yeasts and higher eukaryotes. RNA. 2017;23:1060-1067 pubmed publisher
    ..the worm Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the frog Xenopus tropicalis We demonstrated that Pus1p from C...
  23. Zhang Y, Qin C, Yang L, Lu R, Zhao X, Nie G. A comparative genomics study of carbohydrate/glucose metabolic genes: from fish to mammals. BMC Genomics. 2018;19:246 pubmed publisher
    ..containing 791, 593, 523, 666 and 698 carbohydrate/glucose metabolic genes from the genomes of Danio rerio, Xenopus tropicalis, Gallus gallus, Mus musculus and Homo sapiens, respectively, and most of these genes in our database are ..
  24. Suzuki M, Shibata Y, Ogushi Y, Okada R. Molecular machinery for vasotocin-dependent transepithelial water movement in amphibians: aquaporins and evolution. Biol Bull. 2015;229:109-19 pubmed
    ..In addition, AQP5 (AQP5a) and AQP5L (AQP5b) were identified from Xenopus tropicalis Gray, 1864, and AQP5 was localized to the apical membrane of luminal epithelial cells of the urinary bladder ..
  25. Flores E, García Añoveros J. TRPML2 and the evolution of mucolipins. Adv Exp Med Biol. 2011;704:221-8 pubmed publisher
    ..Trpml2 is next to Trpml3 in all tetrapod genomes except that of the frog Xenopus tropicalis and of the domesticated pig, which seems to lack most of the Trpml3 gene...
  26. Maharana S, Pollet N, Schlosser G. Identification of novel cis-regulatory elements of Eya1 in Xenopus laevis using BAC recombineering. Sci Rep. 2017;7:15033 pubmed publisher
    ..Here we use a library of Xenopus tropicalis genomic sequences in bacterial artificial chromosomes (BAC) to analyze the genomic region surrounding the ..
  27. Säfholm M, Ribbenstedt A, Fick J, Berg C. Risks of hormonally active pharmaceuticals to amphibians: a growing concern regarding progestagens. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
    ..NET) and progesterone (P) exposure to 0, 1, 10 or 100 ng l(-1) (nominal) on oogenesis in the test species Xenopus tropicalis. Very little information was found on toxicity of environmentally relevant concentrations of pharmaceuticals ..
  28. Okada M, Shi Y. EVI and MDS/EVI are required for adult intestinal stem cell formation during postembryonic vertebrate development. FASEB J. 2018;32:431-439 pubmed publisher
    ..Using the T3-dependent metamorphosis in Xenopus tropicalis as a model, we show here that high levels of EVI and MDS/EVI are expressed in the intestine at the ..
  29. Loriol C, Dupuy F, Rampal R, Dlugosz M, Haltiwanger R, Maftah A, et al. Molecular evolution of protein O-fucosyltransferase genes and splice variants. Glycobiology. 2006;16:736-47 pubmed publisher
    ..The last common ancestor of all analyzed bilaterian species would be predicted to possess polyexonic Pofut genes in their genome...
  30. Kugelstadt D, Haberkamp M, Hankeln T, Burmester T. Neuroglobin, cytoglobin, and a novel, eye-specific globin from chicken. Biochem Biophys Res Commun. 2004;325:719-25 pubmed publisher
    ..0. Phylogenetic analyses suggest that this globin is most closely related to the cytoglobin lineage. Although the function of this eye-globin remains presently uncertain, it adds an additional diversity to the vertebrate globin family...
  31. Nakabayashi K, Amann D, Ren Y, Saarialho Kere U, Avidan N, Gentles S, et al. Identification of C7orf11 (TTDN1) gene mutations and genetic heterogeneity in nonphotosensitive trichothiodystrophy. Am J Hum Genet. 2005;76:510-6 pubmed publisher
    ..Given the absence of cutaneous photosensitivity in the patients with C7orf11 mutations, together with the protein's nuclear localization, C7orf11 may be involved in transcription but not DNA repair...
  32. Cruciat C, Hassler C, Niehrs C. The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. J Biol Chem. 2006;281:12986-93 pubmed
    ..The results indicate that Erlectin functions in N-glycan recognition in the endoplasmic reticulum, suggesting that it may regulate glycoprotein traffic. ..
  33. Goetz S, Brown D, Conlon F. TBX5 is required for embryonic cardiac cell cycle progression. Development. 2006;133:2575-84 pubmed publisher
    ..Thus, these studies establish a role for TBX5 in regulating the progression of the cardiac cell cycle...
  34. Park J, Semyonov J, Chang C, Yi W, Warren W, Hsu S. Origin of INSL3-mediated testicular descent in therian mammals. Genome Res. 2008;18:974-85 pubmed publisher
  35. Gupta R, Wills A, Ucar D, Baker J. Developmental enhancers are marked independently of zygotic Nodal signals in Xenopus. Dev Biol. 2014;395:38-49 pubmed publisher
    ..we examined whether developmental enhancers were influenced by Nodal signaling during early embryogenesis in Xenopus tropicalis. We find that developmental enhancers, defined by the active enhancer chromatin marks H3K4me1 and H3K27ac, ..
  36. Nie S, Bronner M. Dual developmental role of transcriptional regulator Ets1 in Xenopus cardiac neural crest vs. heart mesoderm. Cardiovasc Res. 2015;106:67-75 pubmed publisher
    ..Our results reinforce the suggestion that proper interaction between these tissues is critical for normal heart development. ..
  37. Howard C, Lutterschmidt D. The Effects of Melatonin on Brain Arginine Vasotocin: Relationship with Sex and Seasonal Differences in Melatonin Receptor Type 1 in Green Treefrogs (Hyla cinerea). J Neuroendocrinol. 2015;27:670-9 pubmed publisher
    ..Based on these findings, we suggest that MT1 plays a role in mediating the interactions between melatonin and vasotocin that regulate seasonal and sexually dimorphic changes in sociosexual behaviour. ..
  38. Gibson L, Koch I, Reimer K, Cullen W, Langlois V. Life cycle exposure of the frog Silurana tropicalis to arsenate: Steroid- and thyroid hormone-related genes are differently altered throughout development. Gen Comp Endocrinol. 2016;234:133-41 pubmed publisher
    ..3 and 0.8ppm of arsenate (pentavalent arsenic; As(V)) were performed in the Western clawed frog (Silurana tropicalis) from the gastrulae stage (developmental stage Nieuwkoop-Faber; NF12) until ..
  39. Bogdanović O, Smits A, de la Calle Mustienes E, Tena J, Ford E, Williams R, et al. Active DNA demethylation at enhancers during the vertebrate phylotypic period. Nat Genet. 2016;48:417-26 pubmed publisher
    ..Here we report widespread DNA demethylation of enhancers during the phylotypic period in zebrafish, Xenopus tropicalis and mouse...
  40. Shigeta M, Sakane Y, Iida M, Suzuki M, Kashiwagi K, Kashiwagi A, et al. Rapid and efficient analysis of gene function using CRISPR-Cas9 in Xenopus tropicalis founders. Genes Cells. 2016;21:755-71 pubmed publisher
    ..regularly interspaced short palindromic repeats (CRISPR)-Cas system, have facilitated reverse genetics in Xenopus tropicalis. To establish a practical workflow for analyzing genes of interest using CRISPR-Cas9, we examined various ..
  41. Good M, Heald R. Preparation of Cellular Extracts from Xenopus Eggs and Embryos. Cold Spring Harb Protoc. 2018;2018:pdb.prot097055 pubmed publisher
    ..In the second method, the basic procedure is adapted for Xenopus tropicalis eggs with minor modifications to accommodate differences in frog size, timing of egg laying, and ..
  42. Knochel W, Pfanne K, Beck J, Meyerhof W. Nucleotide sequence of a larval alpha globin gene from Xenopus tropicalis. Nucleic Acids Res. 1988;16:1625 pubmed
  43. D Souza A, Lee M, Taverner N, Mason J, Carruthers S, Smith J, et al. Molecular components of the endoderm specification pathway in Xenopus tropicalis. Dev Dyn. 2003;226:118-27 pubmed publisher
    ..antisense oligos and possibly forward genetics are likely to be more effective in the diploid species Xenopus tropicalis than in the pseudotetraploid Xenopus laevis...
  44. Fletcher R, Baker J, Harland R. FGF8 spliceforms mediate early mesoderm and posterior neural tissue formation in Xenopus. Development. 2006;133:1703-14 pubmed publisher
    ..Furthermore, FGF8 signaling is necessary for proper posterior neural formation; loss of either FGF8a or a reduction in both FGF8a and FGF8b causes a reduction in the hindbrain and spinal cord domains...
  45. Freeman S, Moore W, Guiral E, Holme A, Turnbull J, Pownall M. Extracellular regulation of developmental cell signaling by XtSulf1. Dev Biol. 2008;320:436-45 pubmed publisher
    ..We show that while XtSulf1 can enhance the axis-inducing activity of Wnt11, XtSulf1 acts during embryogenesis to restrict BMP and FGF signaling...
  46. Rodr guez Seguel E, Alarc n P, G mez Skarmeta J. The Xenopus Irx genes are essential for neural patterning and define the border between prethalamus and thalamus through mutual antagonism with the anterior repressors Fezf and Arx. Dev Biol. 2009;329:258-68 pubmed publisher
    ..This mutual repression is likely direct. Finally, we show that Arx, another anteriorly expressed repressor, also contribute to delineate the anterior border of Irx expression...
  47. Ohkita M, Saito S, Imagawa T, Takahashi K, Tominaga M, Ohta T. Molecular cloning and functional characterization of Xenopus tropicalis frog transient receptor potential vanilloid 1 reveal its functional evolution for heat, acid, and capsaicin sensitivities in terrestrial vertebrates. J Biol Chem. 2012;287:2388-97 pubmed publisher
    ..In this study we cloned Xenopus tropicalis frog TRPV1 (xtTRPV1), and functional characterization was performed using HeLa cells heterologously ..
  48. Fish M, Nakayama T, Fisher M, Hirsch N, Cox A, Reeder R, et al. Xenopus mutant reveals necessity of rax for specifying the eye field which otherwise forms tissue with telencephalic and diencephalic character. Dev Biol. 2014;395:317-330 pubmed publisher
    ..We describe here a Xenopus tropicalis rax mutant, the first mutant analyzed in detail from a reverse genetic screen...
  49. Chevalier B, Adamiok A, Mercey O, Revinski D, Zaragosi L, Pasini A, et al. miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways. Nat Commun. 2015;6:8386 pubmed publisher
    ..Our study illustrates the intricate role played by miR-34/449 in coordinating several steps of a complex differentiation programme by regulating distinct signalling pathways. ..
  50. Zhu J, Hu L, Li L, Huang X, Shi H. Comparison of phenotypic and global gene expression changes in Xenopus tropicalis embryos induced by agonists of RAR and RXR. Toxicol Appl Pharmacol. 2017;330:40-47 pubmed publisher
    ..In the present study, we comparatively investigated the phenotypic and global gene expression changes in Xenopus tropicalis embryos induced by three different agonists, including a RAR selective ligand (all-trans retinoic acid, at-..
  51. Ro l G, van den Broek O, Spieker N, Peterson Maduro J, Destr e O. Tcf-1 expression during Xenopus development. Gene Expr Patterns. 2003;3:123-6 pubmed
    We report the cloning and expression of Xenopus Tcf-1. The amino acid sequence of Tcf-1 of Xenopus laevis and Xenopus tropicalis is closely related to that of chicken, mouse and man...
  52. Czaplinski K, K cher T, Schelder M, Segref A, Wilm M, Mattaj I. Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis. Dev Cell. 2005;8:505-15 pubmed publisher
    ..Our results associate an hnRNP D protein with mRNA localization and have implications for several functions mediated by this important protein family...
  53. Showell C, Christine K, Mandel E, Conlon F. Developmental expression patterns of Tbx1, Tbx2, Tbx5, and Tbx20 in Xenopus tropicalis. Dev Dyn. 2006;235:1623-30 pubmed publisher
    ..analysis, and developmental expression patterns of four members of the T-box gene family in the diploid frog Xenopus tropicalis. These four genes-Tbx1, Tbx2, Tbx5, and Tbx20-have been shown to influence cardiac development in a variety ..
  54. Onorati M, Cremisi F, Liu Y, He R, Barsacchi G, Vignali R. A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina. Neural Dev. 2007;2:12 pubmed publisher
    ..We propose that this box is a major domain of XOTX proteins that provides them with the appropriate developmental specificity in retinal histogenesis...
  55. Mangiamele L, Thomson C, Lebonville C, Burmeister S. Characterization of the plasticity-related gene, Arc, in the frog brain. Dev Neurobiol. 2010;70:813-25 pubmed publisher
    ..To begin to address this gap, we identified Arc in two frog species, Xenopus tropicalis and Physalaemus pustulosus, and characterized its expression in the brain of P. pustulosus...
  56. Rankin S, Gallas A, Neto A, G mez Skarmeta J, Zorn A. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/?-catenin-mediated lung specification in Xenopus. Development. 2012;139:3010-20 pubmed publisher
    ..These results significantly advance our understanding of early lung development and may impact strategies to differentiate respiratory tissue from stem cells...
  57. Huang B, Yang C, Wojton J, Huang N, Chen C, Soderblom E, et al. Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A). J Biol Chem. 2014;289:35882-90 pubmed publisher
  58. Brinkmann E, Mattes B, Kumar R, Hagemann A, Gradl D, Scholpp S, et al. Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation. J Biol Chem. 2016;291:13730-42 pubmed publisher
    ..We propose that sFRPs can act as a molecular switch, channeling the signal input for different non-canonical Wnt pathways during vertebrate gastrulation. ..
  59. Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev A. Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance. J Biol Chem. 2015;290:19218-32 pubmed publisher
  60. Gentsch G, Spruce T, Monteiro R, Owens N, Martin S, Smith J. Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus. Dev Cell. 2018;44:597-610.e10 pubmed publisher
    ..implications of genetic KO versus MO-mediated KD of the mesoderm-specifying Brachyury paralogs in the frog Xenopus tropicalis. While both KO and KD embryos fail to activate the same core gene regulatory network, resulting in virtually ..
  61. Stalder J, Wirthmüller U, Beck J, Gruber A, Meyerhof W, Knochel W, et al. Primary structure and evolutionary relationship between the adult alpha-globin genes and their 5'-flanking regions of Xenopus laevis and Xenopus tropicalis. J Mol Evol. 1988;28:64-71 pubmed
    ..laevis. We therefore conclude that these conserved upstream elements may represent regulatory sequences for cell-specific regulation of the adult Xenopus globin genes. ..
  62. Huanosta Gutiérrez A, Espino Saldaña A, Reyes J, Pétriz A, Miledi R, Martinez Torres A. TMEM16A alternative splicing isoforms in Xenopus tropicalis: distribution and functional properties. Biochem Biophys Res Commun. 2014;446:1096-101 pubmed publisher
    Oocytes of Xenopus tropicalis elicit a Ca(2+)-dependent outwardly rectifying, low-activating current (ICl,Ca) that is inhibited by Cl(-) channel blockers...
  63. Miranda R, Searcy B, Propper C. Arginine vasotocin induces calling behavior with a female social stimulus and interacts with gonadotropins to affect sexual behaviors in male Xenopus tropicalis. Physiol Behav. 2015;151:72-80 pubmed publisher
    ..To study the impact of AVT and social stimuli on calling in male Xenopus tropicalis, we injected males with vehicle, 1 μg, or 10 μg AVT and recorded vocalizations under four social ..
  64. Yun S, Furlong M, Sim M, Cho M, Park S, Cho E, et al. Prevertebrate Local Gene Duplication Facilitated Expansion of the Neuropeptide GPCR Superfamily. Mol Biol Evol. 2015;32:2803-17 pubmed publisher
    ..Our study describes a presumptive evolutionary mechanism and development pathway of the vertebrate rhodopsin-like GPCR and cognate neuropeptide families from the urbilaterian ancestor to modern vertebrates. ..
  65. Spirhanzlova P, Dhorne Pollet S, Fellah J, da Silva C, Tlapakova T, Labadie K, et al. Construction and characterization of a BAC library for functional genomics in Xenopus tropicalis. Dev Biol. 2017;426:255-260 pubmed publisher
    Large insert genomic DNA libraries are useful resources for genomic studies. Although the genome of Xenopus tropicalis stands as the amphibian reference genome because it benefitted from large-scale sequencing studies, physical mapping ..
  66. Matsufuji S, Matsufuji T, Miyazaki Y, Murakami Y, Atkins J, Gesteland R, et al. Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme. Cell. 1995;80:51-60 pubmed
    ..The shift site sequence, UCC-UGA-U, is not similar to other known frameshift sites. The mechanism does not seem to involve re-pairing of peptidyl-tRNA in the new frame but rather reading or occlusion of a fourth base...
  67. Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, et al. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature. 2005;438:867-72 pubmed publisher
    ..Our results reveal an evolutionarily conserved mechanism that couples Wnt receptor activation to the cytoplasmic signal transduction apparatus...
  68. Kobayashi Y, Hamamoto A, Hirayama T, Saito Y. Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis. Gen Comp Endocrinol. 2015;212:114-23 pubmed publisher
    ..In this study, we cloned and characterized four MCHR subtypes from the diploid species Xenopus tropicalis (X-MCHRs; X-MCHR1a, R1b, R2a, and R2b)...
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    ..Here, we report that during Xenopus tropicalis development two waves of Smad2 phoshorylation can be observed, first during gastrulation and then a second ..
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    ..representative of the different subfamilies and determined their spatiotemporal expression patterns during Xenopus tropicalis embryogenesis...
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    ..Our results suggest that phosphorylation of vimentin at Ser38 may regulate the integrin-ligand interaction, thus providing a molecular basis for antivimentin therapeutic strategies. ..
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    ..set of genomic microarray chips covering about 8000 bp flanking the predicted transcription start sites in Xenopus tropicalis for genome wide identification of TR binding sites...
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    ..These findings represent a significantly revised view of Cdc42-signaling and shed light on the pathogenesis of Wiskott-Aldrich syndrome...
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    ..Thus, neither cyclin B2 degradation nor Thr-161 dephosphorylation participates directly in CDK1 inactivation as measured by histone H1 kinase decline upon the exit from mitotic M-phase in Xenopus embryo extract...
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    ..In conclusion, we provide evidence that CD41 can be used as both an identification and activation marker for basophils during homeostasis and immune challenge. ..
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    ..viridescens and Xenopus tropicalis (Anura)...
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    ..Our findings indicated that besides being a negative regulator of Tbx6, bowline itself is also regulated by Tbx6, suggesting the negative feedback loop of Tbx6-Bowline in the termination step of somite segmentation. ..
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    ..study we show that the metalloproteinase activity of ADAM13 also plays important roles in eye development in Xenopus tropicalis. Knockdown of ADAM13 results in reduced expression of eye field markers pax6 and rx1, as well as that of the ..
  83. Nimmo R, Ciau Uitz A, Ruiz Herguido C, Soneji S, Bigas A, Patient R, et al. MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny. Dev Cell. 2013;26:237-49 pubmed publisher
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    ..duplication after the interspecific hybridization of 2 diploid species closely related to Silurana/Xenopus tropicalis (XTR)...
  85. Nakamura K, Sano S, Fuster J, Kikuchi R, Shimizu I, Ohshima K, et al. Secreted Frizzled-related Protein 5 Diminishes Cardiac Inflammation and Protects the Heart from Ischemia/Reperfusion Injury. J Biol Chem. 2016;291:2566-75 pubmed publisher
    ..These results indicate that Sfrp5 functions to antagonize inflammatory responses after I/R in the heart, possibly through a mechanism involving non-canonical Wnt5a/JNK signaling. ..
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    ..Based on the established naming nomenclature for similar enzymes, we suggest that METTL12 be renamed CS-KMT (gene name CSKMT). ..
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    ..report the genomic and biochemical characterization of two amphibian hepcidins (tHEP1 and tHEP2) from the Western clawed frog (Xenopus tropicalis)...
  89. Sakata H, Maéno M. Nkx2.5 is involved in myeloid cell differentiation at anterior ventral blood islands in the Xenopus embryo. Dev Growth Differ. 2014;56:544-54 pubmed publisher
    ..We suggest that C/EBPα is an unequivocal factor for myeloid cell differentiation in the aVBI and that Nkx2.5 and GATA4 cooperate with C/EBPα for promotion of myeloid cell differentiation. ..
  90. Shewade L, Schneider K, Brown A, Buchholz D. In-vivo regulation of Krüppel-like factor 9 by corticosteroids and their receptors across tissues in tadpoles of Xenopus tropicalis. Gen Comp Endocrinol. 2017;248:79-86 pubmed publisher
    ..receptors in key target tissues, brain, lungs, and tail, during larval and metamorphic stages in Xenopus tropicalis. We also studied the corticosteroid regulation of klf9 in these tissues in-vivo using exogenous hormone ..
  91. Charney R, Forouzmand E, Cho J, Cheung J, Paraiso K, Yasuoka Y, et al. Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program. Dev Cell. 2017;40:595-607.e4 pubmed publisher
    ..Our findings suggest that Foxh1 functions at the top of a hierarchy of interactions by marking developmental genes for activation, beginning with the onset of zygotic gene expression. ..
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    ..Rates of nucleotide substitutions indicate that both genes are under similar evolutionary constraints. X. laevis Mdh2 genes can be used as markers for physical mapping and linkage analysis...