Genomes and Genes
western clawed frog
Alias: Silurana tropicalis, Xenopus tropicalis, Xenopus (Silurana) tropicalis, Silurana tropicalis Gray, 1864, Xenopus laevis tropicalis, Xenopus tropicalis (Gray, 1864)
Publications273 found, 100 shown here
- Identification and expression of NEU3, a novel human sialidase associated to the plasma membraneE Monti
Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Via Olgettina 58, 20132 Milan, Italy and Department of Biomedical Science and Biotechnology, University of Brescia, Via Valsabbina 19, 25123 Brescia, Italy
Biochem J 349:343-51. 2000..8. Immunofluorescence staining of the transfected COS7 cells demonstrated the protein's localization in the plasma membrane...
- Depletion of the cell-cycle inhibitor p27(Xic1) impairs neuronal differentiation and increases the number of ElrC(+) progenitor cells in Xenopus tropicalisSamantha Carruthers
Wellcome Trust Cancer Research UK Institute, Tennis Court Road, Cambridge CB2 1QR, UK
Mech Dev 120:607-16. 2003..For such knockdown studies, Xenopus tropicalis is a better model system than Xenopus laevis, since it has a diploid genome. Indeed, while X...
- Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene familyE Monti
Department of Biomedical Science and Biotechnology, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
Genomics 83:445-53. 2004..Immunofluorescence staining and Western blot analysis demonstrated the association of NEU4 with the inner cell membranes...
- Expression of Xenopus tropicalis noggin1 and noggin2 in early development: two noggin genes in a tetrapodRussell B Fletcher
Division of Genetics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Gene Expr Patterns 5:225-30. 2004We report the identification of two distinct noggin genes in the tetrapod Xenopus tropicalis. Noggin functions to antagonize BMP signaling in many developmental contexts, and much work has explored its role in early vertebrate development...
- Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codonsMichael T Howard
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
EMBO J 24:1596-607. 2005..Sequences capable of forming strong RNA structures were also identified 3' adjacent to, or near, selenocysteine-encoding UGA codons in the Sps2, SelH, SelO, and SelT selenoprotein genes...
- Specific expression of olfactory binding protein in the aerial olfactory cavity of adult and developing XenopusJulie Millery
Centre Européen des Sciences du Goût, CNRS UMR 5170, 15 rue Hugues Picardet, 21000 Dijon, France
Eur J Neurosci 22:1389-99. 2005..We therefore purified and cloned OBPs in two Xenopus species. Xenopus laevis OBP (XlaeOBP) and Xenopus tropicalis OBP (XtroOBP) exhibit 158 and 160 amino acids, respectively, sharing 89 residues...
- Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylationGuillermo Barreto
Division of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Nature 445:671-5. 2007..Active demethylation occurs by DNA repair and Gadd45a interacts with and requires the DNA repair endonuclease XPG. We conclude that Gadd45a relieves epigenetic gene silencing by promoting DNA repair, which erases methylation marks...
- BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivoJeffrey K Huang
Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK
BMC Dev Biol 7:59. 2007..Brain derived neurotrophic factor, BDNF is known to stimulate axon outgrowth and branching. The goal of this study is to determine whether BDNF functions as the proposed target recognition signal in the Xenopus cement gland...
- FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formationMartin Roth
Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
Development 137:1553-62. 2010..Here, we show that interaction of FoxG1 with TLE2, a Xenopus tropicalis co-repressor of the Groucho/TLE family, is crucial for regulating the early activity of FoxG1...
- Specific histone lysine 4 methylation patterns define TR-binding capacity and differentiate direct T3 responsesPatrice Bilesimo
Museum national d histoire naturelle, Départment Régulation Développement et Diversité Moléculaire, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique, Evolution des Regulations Endocriniennes, 75231 Paris Cedex 05, France
Mol Endocrinol 25:225-37. 2011..Reverse transcription-real-time quantitative PCR analysis on Xenopus tropicalis tadpole brain and tail fin showed differences in expression levels in premetamorphic tadpoles (lower for TH/..
- Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterningKhalid A Fakhro
Department of Genetics, The Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 108:2915-20. 2011..These effects were specific, because 0 of 13 control genes from rare Htx or control copy number variations produced significant LR abnormalities (P = 0.001). These findings identify genes not previously implicated in LR patterning...
- Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loopsEdoardo Giacopuzzi
Department of Biomedical Sciences and Biotechnology, Unit of Biology and Genetics, University of Brescia, Viale Europa 11, Brescia 25123, Italy
BMC Biochem 12:45. 2011..These features prompted us to extend our studies on this protein family in birds, to get insights on the evolution of this class of glycohydrolases...
- The permeability of reconstituted nuclear pores provides direct evidence for the selective phase modelBastian B Hülsmann
Abteilung Zelluläre Logistik, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, D 37077 Gottingen, Germany
Cell 150:738-51. 2012..Our data exclude alternative models that are based solely on an interaction between the FG repeats and NTRs and indicate that the barrier is formed by a sieve-like FG hydrogel...
- Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genesS Knochel
Abteilung Biochemie, Universitat Ulm, Albert Einstein Allee 11, D 89081, Ulm, Germany
Mech Dev 109:79-82. 2001The Xenopus tropicalis BMP-2 and BMP-4 genes have been cloned and sequenced. A comparison with the corresponding genes from X. laevis reveals that the BMP-4 genes are conserved at a higher extent than the BMP-2 genes...
- Cloning and expression of the Cdx family from the frog Xenopus tropicalisJohn S Reece-Hoyes
Department of Biology, University of York, York, United Kingdom
Dev Dyn 223:134-40. 2002..In this study, we report the cloning of cDNAs from the Cdx genes of the amphibian Xenopus tropicalis. Xenopus tropicalis is a diploid species, related to the commonly used laboratory animal Xenopus laevis, and ..
- FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formationJeremy M Sivak
The Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge
Dev Cell 8:689-701. 2005..We identified two genes for each family in Xenopus tropicalis: Xtsprouty1, Xtsprouty2, Xtspred1, and Xtspred2...
- Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysisAna C Fierro
CNRS UMR 8080, F 91405 Orsay, France
BMC Genomics 8:118. 2007The western African clawed frog Xenopus tropicalis is an anuran amphibian species now used as model in vertebrate comparative genomics. It provides the same advantages as Xenopus laevis but is diploid and has a smaller genome of 1.7 Gbp...
- Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio)Marta Manzoni
Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
Biochem J 408:395-406. 2007..Overall, the redundancy of sialidases together with their expression profile and their activity exerted on gangliosides of living cells indicate the biological relevance of this class of enzymes in zebrafish...
- Xenopus tropicalis allurin: expression, purification, and characterization of a sperm chemoattractant that exhibits cross-species activityLindsey A Burnett
Molecular and Cellular Biology Program, School of Life Sciences, Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287 4501, USA
Dev Biol 316:408-16. 2008..Here we report identification, purification, and characterization of Xenopus tropicalis (Xt) allurin, a homologous protein in X. tropicalis...
- Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6Anita Abu-Daya
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
Dev Biol 336:20-9. 2009..Forward genetic screens in Xenopus tropicalis have identified more than 80 mutations affecting diverse developmental processes, including cardiac ..
- Cloning and expression analysis of the anterior parahox genes, Gsh1 and Gsh2 from Xenopus tropicalisJean C Illes
Department of Biology, University of York, York, United Kingdom
Dev Dyn 238:194-203. 2009..We report the cloning of two Gsx genes, Gsh1 and Gsh2, from the frog Xenopus tropicalis. We demonstrate the existence of a single, intact Xenopus ParaHox cluster, containing Gsh1, Pdx, and Cdx2, ..
- Pattern and morphogenesis of presumptive superficial mesoderm in two closely related species, Xenopus laevis and Xenopus tropicalisDavid R Shook
Department of Biology, University of Virginia, Gilmer Hall, Charlottesville, VA 22903, USA
Dev Biol 270:163-85. 2004..superficial component of the presumptive mesoderm ingresses into the underlying deep mesenchymal layer in Xenopus tropicalis and extend our previous findings for Xenopus laevis...
- Cornea-lens transdifferentiation in the anuran, Xenopus tropicalisJ J Henry
Department of Cell and Structural Biology, University of Illinois, 601 South Goodwin Avenue, Urbana, IL 61801, USA
Dev Genes Evol 211:377-87. 2001..These findings are discussed in terms of the evolution of this developmental process within the anurans...
- Excision of the Tol2 transposable element of the medaka fish Oryzias latipes in Xenopus laevis and Xenopus tropicalisKoichi Kawakami
Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
Gene 338:93-8. 2004..Our present study suggests that the Tol2 transposon system should be used as a novel genetic tool to develop transgenesis and mutagenesis methods in Xenopus...
- Comparative sensitivity of Xenopus tropicalis and Xenopus laevis as test species for the FETAX modelDouglas J Fort
Fort Environmental Laboratories, 1414 South Sangre, Stillwater, OK 74074, USA
J Appl Toxicol 24:443-57. 2004The use of Xenopus tropicalis as an alternative test species for the Frog Embryo Teratogenesis Assay-Xenopus (FETAX) model was evaluated...
- Experimental analysis of lens-forming capacity in Xenopus borealis larvaeSergio Filoni
Department of Biology, Tor Vergata University, Roma, Italy
J Exp Zool A Comp Exp Biol 305:538-50. 2006..anuran amphibians known to have the capacity to regenerate a lens after lentectomy were Xenopus laevis and Xenopus tropicalis. This regeneration process occurs during the larval life through transdifferentiation of the outer cornea ..
- Defining a large set of full-length clones from a Xenopus tropicalis EST projectMichael J Gilchrist
Wellcome Trust Cancer Research UK Gurdon Institute, Cambridge CB21QR, UK
Dev Biol 271:498-516. 2004..Xenopus, and in particular the diploid Xenopus tropicalis, is also ideal for functional genomics...
- Cloning and expression of xP1-L, a new marker gene for larval surface mucous cells of tadpole stomach in Xenopus laevisMasayuki Ikuzawa
Life Science Institute, Sophia University, Tokyo 102 8554, Japan
Gene Expr Patterns 8:12-8. 2007..A new gene homologous to xP1 was obtained and named xP1-L. In the genome database of Silurana tropicalis, we found a homologue of xP1-L and named it stP1-L...
- Regulation of the G2/M transition in oocytes of xenopus tropicalisJennifer S Stanford
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 260:438-48. 2003..Oocytes of Xenopus tropicalis offer several practical advantages over those of X...
- Ancestral organization of the MHC revealed in the amphibian XenopusYuko Ohta
Department of Microbiology and Immunology, University of Maryland, 655 West Baltimore Street, BRB13 009, Baltimore, MD 21201, USA
J Immunol 176:3674-85. 2006With the advent of the Xenopus tropicalis genome project, we analyzed scaffolds containing MHC genes. On eight scaffolds encompassing 3.65 Mbp, 122 MHC genes were found of which 110 genes were annotated...
- Xenopus microRNA genes are predominantly located within introns and are differentially expressed in adult frog tissues via post-transcriptional regulationGuo Qing Tang
Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695 7622, USA
Genome Res 18:104-12. 2008..Xenopus genome databases using known human pre-miRNAs as query sequences, more than 300 genes encoding 142 Xenopus tropicalis miRNAs were identified...
- Regulatory elements of Xenopus col2a1 drive cartilaginous gene expression in transgenic frogsRyan Kerney
Biology Department, Dalhousie University, Halifax, NS, Canada
Int J Dev Biol 54:141-50. 2010..These constructs contain a portion of the Xenopus tropicalis col2a1 intron, which aligns to a cartilage-specific intronic enhancer that has been well characterized in ..
- Structural and biological properties of erythropoietin in Xenopus laevisNami Nogawa-Kosaka
Graduate School of Advanced Science and Engineering, Center for Advanced Life and Medical Science, Waseda University, Tokyo, Japan
Exp Hematol 38:363-72. 2010..We aimed to investigate the structural and functional conservation of the EPO-EPOR system in amphibian erythropoiesis, using Xenopus laevis as a model...
- A third striated muscle actin gene is expressed during early development in the amphibian Xenopus laevisT Mohun
Cancer Research Campaign, Department of Zoology, Cambridge, England
J Mol Biol 202:67-76. 1988..The related, diploid species, Xenopus tropicalis, possesses a single copy of the alpha 3 gene and its transcript is similarly conserved in nucleotide ..
- Clotrimazole exposure modulates aromatase activity in gonads and brain during gonadal differentiation in Xenopus tropicalis frogsIrina Gyllenhammar
Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala CRU, Norbyvägen 18 A, 75236 Uppsala, Sweden
Aquat Toxicol 91:102-9. 2009..larval exposure to clotrimazole on aromatase activity in brain and gonads, and on gonadal differentiation in Xenopus tropicalis frogs...
- Isolation, sequence identification and expression profile of three novel genes Rab2A, Rab3A and Rab7A from Black-boned sheep (Ovis aries)Y D He
Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China
Mol Biol (Mosk) 44:20-7. 2010..domain and is very similar to the Rab3A proteins of four species--cattle (99%), African clawed frog (99%), Western clawed frog (98%) and zebrafish (95%)...
- Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene familyJared V Goldstone
Department of Biology, Woods Hole Oceanographic Institution, Woods Hole
Mol Biol Evol 24:2619-31. 2007..tunicates and echinoderms), and several new CYP1 genes in vertebrates (chicken, Gallus gallus and frog, Xenopus tropicalis)...
- Evolution of serum albumin intron-1 is shaped by a 5' truncated non-long terminal repeat retrotransposon in western Palearctic water frogs (Neobatrachia)Jörg Plötner
Museum für Naturkunde, Leibniz Institut für Evolutions und Biodiversitätsforschung an der Humboldt Universität zu Berlin, Invalidenstrasse 43, 10115 Berlin, Germany
Mol Phylogenet Evol 53:784-91. 2009..the highly conserved 3' untranslated region (3' UTR), RanaCR1-like elements occur also in the genome of Xenopus tropicalis and Rana temporaria. Unlike other CR1 elements, RanaCR1 contains a CA microsatellite in its 3' UTR...
- Phylogenetic analysis of the tenascin gene family: evidence of origin early in the chordate lineageR P Tucker
Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA 95616, USA
BMC Evol Biol 6:60. 2006..the urochordate Ciona intestinalis, the pufferfish Tetraodon nigroviridis and Takifugu rubripes and the frog Xenopus tropicalis were identified and their gene organization and predicted protein products compared with the previously ..
- Development of biomarkers of endocrine disrupting activity in emerging amphibian model, Silurana (Xenopus) tropicalisMinoru Takase
Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, 1 3 1 Kagamiyama, Higashi Hiroshima, Hiroshima 739 8526, Japan
Environ Sci 14:285-96. 2007....
- Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval developmentValérie S Langlois
Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
Gen Comp Endocrinol 166:417-27. 2010..We conclude that cyp19 and srd5 beta are active in early embryogenesis and larval development in Silurana tropicalis and their inhibition affected transcription of genes associated with the thyroid and reproductive axes.
- [Cloning of silkworm 3-hydroxyisobutyrate dehydrogenase gene and its expression patterns analysis in simulated weightless environment]Zongcheng Tian
Key Laboratory for Space Biosciences and Biotechnology, Institute of Special Environmental Biophysics, Faculty of Life Sciences, Northwestern Polytechnical University, Xi an 710072, China
Sheng Wu Gong Cheng Xue Bao 24:2041-8. 2008..similarities of hibadh between silkworm and Burkholderia ambifaria, Drosophila melanogaster, Apis mellifera, Xenopus tropicalis, Mus musculus, Homo sapiens were 46%, 43%, 48%, 44%, 45%, 45%, respectively...
- Development of potent anti-infective agents from Silurana tropicalis: conformational analysis of the amphipathic, alpha-helical antimicrobial peptide XT-7 and its non-haemolytic analogue [G4K]XT-7Anusha P Subasinghage
UCD School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, SEC Strategic Research Cluster, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Biochim Biophys Acta 1804:1020-8. 2010..NH(2)) is a cationic, leucine-rich peptide, first isolated from skin secretions of the frog, Silurana tropicalis (Pipidae)...
- Evolution of pharmacologic specificity in the pregnane X receptorSean Ekins
Collaborations in Chemistry, Inc, Jenkintown, PA, USA
BMC Evol Biol 8:103. 2008..The ligand activation properties of the Western clawed frog (Xenopus tropicalis) PXR and that of a putative vitamin D receptor (VDR)/PXR cloned in this study from the ..
- Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogeneAlasdair J Edgar
Department of Craniofacial Development, King s College, London, UK
BMC Genomics 6:32. 2005..Low levels of TA enzymatic activity have been found in vertebrates. It has been suggested that any detectable activity is due to serine hydroxymethyltransferase and that mammals lack a genuine threonine aldolase...
- Genotyping sex in the amphibian, Xenopus (Silurana) tropicalis, for endocrine disruptor bioassaysAllen W Olmstead
US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, United States
Aquat Toxicol 98:60-6. 2010..This approach to identifying sex-linked markers and developing sex genotyping methods is applicable to other species with genetic sex determination...
- Evaluation of the developmental and reproductive toxicity of methoxychlor using an anuran (Xenopus tropicalis) chronic exposure modelDouglas J Fort
Fort Environmental Laboratories, 1414 South Sangre Road, Stillwater, Oklahoma 74074, USA
Toxicol Sci 81:443-53. 2004..These studies add to the standardization and validation of a useful amphibian test methods capable of evaluating both reproductive and developmental effects of potential endocrine disrupting chemicals over a life cycle exposure...
- Evolution of new hormone function: loss and gain of a receptorD M Irwin
Department of Laboratory Medicine and Pathobiology, Banting and Best Diabetes Centre, University of Toronto, 100 College St, Toronto, Ontario, Canada M5G lL5
J Hered 96:205-11. 2005..receptors for proglucagon-derived peptides from the genomes of two fish (pufferfish and zebrafish), a frog (Xenopus tropicalis), and a bird (chicken)...
- Sex reversal of the amphibian, Xenopus tropicalis, following larval exposure to an aromatase inhibitorAllen W Olmstead
U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, MN, USA
Aquat Toxicol 91:143-50. 2009..exposure to the aromatase inhibitor, fadrozole, during the larval development of the tropical clawed frog, Xenopus tropicalis, would result in masculinization of the developing female gonad...
- Evolution of thermoTRP ion channel homologs in vertebratesShigeru Saito
Laboratory of Bioscience, Faculty of Engineering, Iwate University, 4 3 5 Ueda, Morioka 020 8551, Japan
Physiol Genomics 27:219-30. 2006..searches for mammalian thermoTRP gene homologs in the draft genome sequences of chicken (Gallus gallus), western clawed frog (Xenopus tropicalis), zebrafish (Danio rerio), and pufferfish (Fugu rubripes)...
- Identification and correction of abnormal, incomplete and mispredicted proteins in public databasesAlinda Nagy
Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, H 1113 Budapest, Hungary
BMC Bioinformatics 9:353. 2008....
- Acute toxicity of rice paddy herbicides simetryn, mefenacet, and thiobencarb to Silurana tropicalis tadpolesMasahiro Saka
Kyoto Prefectural Institute of Public Health and Environment, Murakamicho 395, Fushimi ku, Kyoto 612 8369, Japan
Ecotoxicol Environ Saf 73:1165-9. 2010..simetryn, mefenacet, and thiobencarb to amphibians by conducting acute toxicity tests with tadpoles of Silurana tropicalis, which has attracted as a new model species instead of Xenopus laevis...
- Regulation of thyroid hormone-, oestrogen- and androgen-related genes by triiodothyronine in the brain of Silurana tropicalisPaula Duarte-Guterman
Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
J Neuroendocrinol 22:1023-31. 2010..Finally, we have identified sex steroid-related genes that are responsive to T3, providing additional evidence of crosstalk between THs and sex steroids in the tadpole brain...
- Haptoglobin, a hemoglobin-binding plasma protein, is present in bony fish and mammals but not in frog and chickenKrzysztof B Wicher
Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden
Proc Natl Acad Sci U S A 103:4168-73. 2006..Surprisingly, we found that both chicken (Gallus gallus) and the Western clawed frog (Xenopus tropicalis) lack the Hp gene...
- HnRNP A3 genes and pseudogenes in the vertebrate genomesAleksandr V Makeyev
Department of Genetics and Development, Columbia University, NYC, NY 10032, USA
J Exp Zool A Comp Exp Biol 303:259-71. 2005..In addition, we have found and compared hnRNP A3 orthologous genes in Gallus gallus, Xenopus tropicalis, and Danio rerio...
- Evolutionary selection pressure and family relationships among connexin genesVéronique Cruciani
Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
Biol Chem 388:253-64. 2007..The conserved domains of connexins were collected from chicken, Xenopus tropicalis, zebrafish, pufferfish, green spotted pufferfish, Ciona intestinalis and Halocynthia pyriformis (two ..
- Patterns of vertebrate isochore evolution revealed by comparison of expressed mammalian, avian, and crocodilian genesJena L Chojnowski
Department of Zoology, University of Florida, Gainesville, FL 32611, USA
J Mol Evol 65:259-66. 2007..The alligator ESTs were assembled and aligned with their human, mouse, chicken, and western clawed frog orthologs, resulting in 366 alignments...
- Preparation of Xenopus tropicalis whole chromosome painting probes using laser microdissection and reconstruction of X. laevis tetraploid karyotype by Zoo-FISHVladimir Krylov
Faculty of Science, Charles University in Prague, Vinicna 7, 128 44 Prague 2, Czech Republic
Chromosome Res 18:431-9. 2010..In addition, the observed translocation events could explain the origin of individuals with 18 chromosomes in diploid karyotypes, probably extinct after the genesis of the allotetraploid X. laevis (2n = 36)...
- [Importance of development of ecotoxicogenomics in understanding molecular mechanisms of chemicals in developing animals]Taisen Iguchi
National Institutes of Natural Sciences, National Institute for Basic Biology, Okazaki Institute for Integrative Bioscience, Myodaiji, Japan
Nihon Eiseigaku Zasshi 61:11-8. 2006..were cloned in various species, including the American alligator, crocodile, Florida red-bellied turtle, Silurana tropicalis, roach, Fundulus and mosquito fish...
- Downstream of FGF during mesoderm formation in Xenopus: the roles of Elk-1 and Egr-1Oliver Nentwich
Wellcome Trust Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Dev Biol 336:313-26. 2009..Superficially, Xenopus tropicalis embryos with reduced levels of XEgr-1 resemble those lacking XElk-1, but to our surprise, levels of Xbra are ..
- The Western Clawed Frog (Xenopus tropicalis): An Emerging Vertebrate Model for Developmental Genetics and Environmental ToxicologyChris Showell
UNC McAllister Heart Institute, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
CSH Protoc 2009:pdb.emo131. 2009INTRODUCTION Xenopus tropicalis, also known as Silurana tropicalis or the Western clawed frog, is a small, wholly aquatic frog that is found in the countries that lie along the west coast of equatorial Africa from Gabon to Sierra Leone...
- Ontogeny of the bizarre: an osteological description of Pipa pipa (Anura: pipidae), with an account of skeletal development in the speciesL Trueb
Natural History Museum and Biodiversity Research Center Dyche Hall, and Department of Ecology and Evolutionary Biology, The University of Kansas, Lawrence, KS 66045 2454, USA
J Morphol 243:75-104. 2000..In addition, ontogenetic comparisons reveal that the sacrum forms differently in Discoglossus sardus,Silurana tropicalis, and P.pipa. The development of the sphenethmoid region of the skull is the same in P.pipa and X...
- Orthologs of magainin, PGLa, procaerulein-derived, and proxenopsin-derived peptides from skin secretions of the octoploid frog Xenopus amieti (Pipidae)J Michael Conlon
Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
Peptides 31:989-94. 2010..amieti lineage. However, the very low antimicrobial activity of the magainin-AM1 and PGLa-AM2 paralogs suggests the possibility that certain peptides may have evolved toward a new, as yet undetermined, function (neofunctionalization)...
- Evolutionary history of the somatostatin and somatostatin receptorsMuhammad Moaeen-ud-Din
China Education Ministry s Key Laboratory of Animal Breeding, Genetics and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
J Genet 88:41-53. 2009..We used comparative whole genome analysis of Danio rerio, Carassius auratus, Xenopus tropicalis, Gallus gallus, Monodelphis domestica, Homo sapiens, Sus scrofa, Bos taurus, Mus musculus, Rattus norvegicus,..
- Gel-forming mucins appeared early in metazoan evolutionTiange Lang
Department of Medical Biochemistry, Institute of Biomedicine, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
Proc Natl Acad Sci U S A 104:16209-14. 2007..The frog Xenopus tropicalis stands out because the number of gel-forming mucins has markedly increased to at least 25 as compared with 5 ..
- Cryptochrome genes are highly expressed in the ovary of the African clawed frog, Xenopus tropicalisYoko Kubo
Department of Electrical Engineering and Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
PLoS ONE 5:e9273. 2010..In this study, we identified two CRYs, XtCRY1 and XtCRY2 in Xenopus tropicalis, an excellent experimental model species...
- Aging of Xenopus tropicalis eggs leads to deadenylation of a specific set of maternal mRNAs and loss of developmental potentialAnna Kosubek
Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, Essen, Germany
PLoS ONE 5:e13532. 2010..Since the molecular events in aging eggs may be similar in these species, we established in the frog Xenopus tropicalis a defined protocol for delayed fertilization of eggs...
- Evolution of Hoxa-11 in lineages phylogenetically positioned along the fin-limb transitionC H Chiu
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520 8106, USA
Mol Phylogenet Evol 17:305-16. 2000..5 billion years of evolutionary time. Here, Hoxa-11 gene proper sequences were determined for frog (Xenopus tropicalis), coelacanth (Latimeria chalumnae), common zebrafish (Danio rerio; Hoxa-11a and Hoxa-11b paralogs), and ..
- Divergence of conserved non-coding sequences: rate estimates and relative rate testsGunter P Wagner
Department of Ecology and Evolutionary Biology Yale University, New Haven, Connecticut, USA
Mol Biol Evol 21:2116-21. 2004..species: a shark, Heterodontus francisci; a basal ray finned fish, Polypterus senegalus; the amphibian, Xenopus tropicalis; as well as three mammalian species, human, rat and mouse...
- Reproductive toxicity in Xenopus tropicalis after developmental exposure to environmental concentrations of ethynylestradiolIrina Gyllenhammar
Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala CRU, Norbyvagen 18A, 75236 Uppsala, Sweden
Aquat Toxicol 91:171-8. 2009..b>Xenopus tropicalis tadpoles were exposed until metamorphosis to 6, 60, and 600 pM EE(2)...
- Remobilization of Tol2 transposons in Xenopus tropicalisDonald A Yergeau
Department of Pathology, St, Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
BMC Dev Biol 10:11. 2010..integrates its corresponding non-autonomous transposable element into the genome of the diploid frog, Xenopus tropicalis. Tol2 transposons are stable in the frog genome and are transmitted to the offspring at the expected ..
- Teratogenic effects of tetrabromobisphenol A on Xenopus tropicalis embryosHuahong Shi
Department of Environmental Science, Key Laboratory of Urbanization and Ecological Restoration, East China Normal University, Shanghai 200062, China
Comp Biochem Physiol C Toxicol Pharmacol 152:62-8. 2010..We reported exposing Xenopus tropicalis embryos (NF10) to 0.01, 0.1 or 1 mg/L of TBBPA with or without 70 microg/L triiodothyronine (T(3))...
- Control of kidney, eye and limb expression of Bmp7 by an enhancer element highly conserved between speciesDerek Adams
Maine Medical Center Research Institute, 81 Research Drive, Scarborough, Maine 04074, USA
Dev Biol 311:679-90. 2007..conserved both in sequence and position in the Bmp7 locus between different vertebrates, ranging from Xenopus tropicalis to Homo sapiens, demonstrating that there is strong selective pressure for Bmp7 expression at these tissue ..
- Identification of novel transcripts with differential dorso-ventral expression in Xenopus gastrula using serial analysis of gene expressionFernando Faunes
Center for Cell Regulation and Pathology and Center for Aging and Regeneration, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, 8331150, Chile
Genome Biol 10:R15. 2009..In order to identify novel transcripts involved in dorso-ventral patterning, we compared dorsal and ventral transcriptomes of Xenopus tropicalis at the gastrula stage using serial analysis of gene expression (SAGE).
- A systematic search and classification of T2 family miniature inverted-repeat transposable elements (MITEs) in Xenopus tropicalis suggests the existence of recently active MITE subfamiliesAkira Hikosaka
Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Hiroshima 739 8521, Japan
Mol Genet Genomics 283:49-62. 2010..A terminal sequence motif (T2-motif: TTAAAGGRR) was retrieved from the Xenopus tropicalis genome database. We then selected 51- to 1,000-bp MITE candidates framed by an inverted pair of 2 T2-motifs...
- Goosecoid promotes head organizer activity by direct repression of Xwnt8 in Spemann's organizerJ Yao
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
Development 128:2975-87. 2001..Therefore, Gsc promotes head organizer activity by direct repression of Xwnt8 in Spemann's organizer and this activity is essential for anterior development...
- An amphibian with ambition: a new role for Xenopus in the 21st centuryC W Beck
Developmental Biology Programme, School of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
Genome Biol 2:REVIEWS1029. 2001..Possibilities are also emerging for genomic studies using the closely related diploid frog Xenopus tropicalis.
- Secondary neurogenesis in the brain of the African clawed frog, Xenopus laevis, as revealed by PCNA, Delta-1, Neurogenin-related-1, and NeuroD expressionMario F Wullimann
Centre National de la Recherche Scientifique Institute of Neurobiology A Fessard, F 91198 Gif sur Yvette, France
J Comp Neurol 489:387-402. 2005..Altogether, the data presented suggest a common brain bauplan on the level of early proliferation patterns and neurogenic/proneural gene activity in anamniotes, if not vertebrates...
- Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transductionGary Davidson
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Nature 438:867-72. 2005..Our results reveal an evolutionarily conserved mechanism that couples Wnt receptor activation to the cytoplasmic signal transduction apparatus...
- Ras-dva, a member of novel family of small GTPases, is required for the anterior ectoderm patterning in the Xenopus laevis embryoMaria B Tereshina
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, Moscow, Russia
Development 133:485-94. 2006..Together, the data obtained indicate that Ras-dva is an essential component of the signaling network that patterns the early anterior neural plate and the adjacent ectoderm in the Xenopus laevis embryos...
- The evolutionary conservation of the core components necessary for the extrinsic apoptotic signaling pathway, in Medaka fishKazuhiro Sakamaki
Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
BMC Genomics 8:141. 2007..While the apoptotic machinery governing the extrinsic signaling pathway is well characterized in mammals, it is not fully understood in fish...
- Ligand specificity and evolution of liver X receptorsErica J Reschly
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, United States
J Steroid Biochem Mol Biol 110:83-94. 2008..The present study reports the cloning of LXRs from African clawed frog (Xenopus laevis), Western clawed frog (Xenopus tropicalis), and zebrafish (Danio rerio), and their functional characterization and comparison ..
- TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebratesYasuko Onuma
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
Zoolog Sci 25:706-13. 2008..TRIQK proteins are localized to the endoplasmic reticulum membrane. Depletion of endogenous xTRIQK protein in Xenopus embryos causes no detectable morphological or functional changes in tadpoles...
- Expression of Xenopus tropicalis HNF6/Onecut-1Kim E Haworth
Cardiff School of Biosciences, Cardiff University, Biomedical Sciences Museum Avenue, Cardiff, Wales, UK
Int J Dev Biol 53:159-62. 2009..In the present study, we analyzed the pattern of expression of Onecut-1/HNF6 in Xenopus tropicalis using RT-PCR and whole mount in situ hybridization...
- Xenopus tropicalis as a test system for developmental and reproductive toxicityCecilia Berg
Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala CRU, Norbyvägen 18 A, Uppsala, Sweden
J Toxicol Environ Health A 72:219-25. 2009The usefulness of Xenopus tropicalis as a model species to investigate endocrine disruption and developmental reproductive toxicity was assessed...
- Functional dissection of XDppa2/4 structural domains in Xenopus developmentDoreen Siegel
Institute of Biochemistry, University of Ulm, Albert Einstein Allee 11, D 89081 Ulm, Germany
Mech Dev 126:974-89. 2009..The SAP domain is required for association of XDppa2/4 to chromatin and for embryonic survival at later stages of development suggesting epigenetic programming events...
- Identification of an abundant allergen from the sheep louse, Bovicola ovisA Pfeffer
Hopkirk Research Institute, AgResearch Ltd, Private Bag 11008, Palmerston North 4442, New Zealand
Int J Parasitol 40:911-9. 2010..proteins of unknown function from diverse species and weak homology with lipid-binding proteins of Xenopus tropicalis and Galleria mellonella...
- Effects of tributyltin (TBT) on Xenopus tropicalis embryos at environmentally relevant concentrationsSuzhen Guo
Department of Environmental Science, East China Normal University, Shanghai 200062, China
Chemosphere 79:529-33. 2010..In this paper, we exposed embryos of Xenopus tropicalis to 50-400ngL(-1) tributyltin chloride...
- Phylogenetic and developmental study of CD4, CD8 α and β T cell co-receptor homologs in two amphibian species, Xenopus tropicalis and Xenopus laevisAsiya Seema Chida
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Dev Comp Immunol 35:366-77. 2011..Using experimental and computational procedures we identified CD4, CD8α and CD8β gene homologs both in Xenopus tropicalis, whose full genome has been sequenced, and its sister species Xenopus laevis...
- Expansion of voltage-dependent Na+ channel gene family in early tetrapods coincided with the emergence of terrestriality and increased brain complexityHarold H Zakon
Section of Neurobiology, The University of Texas, USA
Mol Biol Evol 28:1415-24. 2011..The duplication of Nav channel genes allowed for greater regional specialization in Nav channel expression, variation in subcellular localization, and enhanced processing of somatosensory input...
- Characterization of a novel Xenopus tropicalis cell line as a model for in vitro studiesLudivine Sinzelle
Institute of Systems and Synthetic Biology, Genopole, CNRS, Universite d Evry Val d Essonne, Genavenir 3 Genopole campus 3, 1 rue Pierre Fontaine, Evry, France
Genesis 50:316-24. 2012..We describe a new permanent fibroblast-type cell line obtained from disaggregated Xenopus tropicalis limb bud. The cell line population doubling time was ~24 h...
- A proteomic approach to investigate the distribution and abundance of surface and internal Fasciola hepatica proteins during the chronic stage of natural liver fluke infection in cattleOrcun Hacariz
TUBITAK Marmara Research Center, Genetic Engineering and Biotechnology Institute, P O Box 21, 41470, Gebze, Kocaeli, Turkey
J Proteome Res 11:3592-604. 2012..Potentially novel F. hepatica proteins showing homology with AKT interacting protein (Xenopus tropicalis), sterol O-acyltransferase 2 (Homo sapiens), and integrin beta 7 (Mus musculus) were identified with high ..
- Developmental regulation of locomotive activity in Xenopus primordial germ cellsKohei Terayama
Department of Life Science, Graduate School of Life Science, University of Hyogo, 3 2 1 Koto, Kamigori, Akou gun, 678 1297, Japan
Dev Growth Differ 55:217-28. 2013..We also showed that the locomotion and blebbing of the PGCs required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling...
- Characterization of an outward rectifying chloride current of Xenopus tropicalis oocytesLenin David Ochoa-de la Paz
Departamento de Neurobiologia Celular y Molecular, Instituto de Neurobiologia, Campus UNAM Juriquilla, Mexico
Biochim Biophys Acta 1828:1743-53. 2013Here, we describe an outward rectifying current in Xenopus tropicalis oocytes that we have called xtClC-or...
- Xenbase, the Xenopus model organism database; new virtualized system, data types and genomesJ Brad Karpinka
University of Calgary Computer Science, Calgary, Alberta, Canada
Nucleic Acids Res 43:D756-63. 2015..Xenopus laevis that is widely used for microinjection and tissue explant-based protocols, and the diploid Xenopus tropicalis which is used for genetics and gene targeting...
- Unliganded thyroid hormone receptor α controls developmental timing in Xenopus tropicalisLuan Wen
Section on Molecular Morphogenesis, Program on Cell Regulation and Metabolism, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
Endocrinology 156:721-34. 2015..We have designed transcriptional activator-like effector nucleases (TALENs) to mutate the TRα gene in Xenopus tropicalis. We show that knockdown of TRα enhances tadpole growth in premetamorphic tadpoles, in part because of ..
- Understanding early organogenesis using a simplified in situ hybridization protocol in XenopusSteven J Deimling
Developmental and Stem Cell Biology, Hospital for Sick Children
J Vis Exp . 2015..Although the protocol describes assessing organogenesis in Xenopus laevis, the same basic protocol can almost certainly be adapted to Xenopus tropicalis and other model systems.
- Sex chromosome conservation, DMRT1 phylogeny and gonad morphology in diploid Palearctic green toads (Bufo viridis subgroup)Stephanie Tamschick
Leibniz Institute of Freshwater Ecology and Inland Fisheries IGB, Berlin, Germany
Cytogenet Genome Res 144:315-24. 2014..Markers corroborate the largest chromosome pair 1 (homologous to linkage group 1 of Xenopus tropicalis) to represent the sex chromosomes in diploid species of the B. viridis subgroup (B. siculus, B...
- Arsenic(+3) and DNA methyltransferases, and arsenic speciation in tadpole and frog life stages of western clawed frogs (Silurana tropicalis) exposed to arsenateIris Koch
Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Canada
Metallomics 7:1274-84. 2015b>Western clawed frog (Silurana tropicalis) embryos were exposed to control, low (nominally 0...
- Molecular asymmetry in the 8-cell stage Xenopus tropicalis embryo described by single blastomere transcript sequencingElena De Domenico
The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK
Dev Biol 408:252-68. 2015..Here we report an unbiased analysis of the distribution of maternal mRNA on all axes of the Xenopus tropicalis 8-cell stage embryo, based on sequencing of single blastomeres whose positions within the embryo are known...
- Hematologic reference intervals for Xenopus tropicalis with partial use of automatic counting methods and reliability of long-term stored samplesLily A Maxham
Department of Biology, University of Prince Edward Island, Charlottetown, PE, Canada
Vet Clin Pathol 45:291-9. 2016The African frog, Xenopus tropicalis, is widely used in biomedical and toxicologic research. Reference intervals (RI) for hematologic variables, valuable to research and health status assessment, have not been established.
- Insertional mutagenesis screen for otic genes in XenopusSigrid Reinsch; Fiscal Year: 2003..aims: (1) We will use insertional mutagenesis to generate stable GFP- expressing lines of the true diploid, Xenopus tropicalis, carrying transgenes expressed in the otic regions...
- Genetic Analysis of Silurana Tropicalis DevelopmentRichard Harland; Fiscal Year: 2005..Our main goal in this proposal is to establish methods that will test the utility of Silurana tropicalis as an additional useful organism for genetic manipulation...
- Richard M Harland; Fiscal Year: 2015..In order to understand normal inner ear development, we will use the genetically tractable frog, Xenopus tropicalis, to investigate the genetic network underlying ear development...
- A genome assembly for Xenopus laevisDANIEL SOLEYMAN ROKHSAR; Fiscal Year: 2013..a comprehensive understanding of life's processes, we propose here to complement the genome assembly of Xenopus tropicalis with a gene and protein level genome assembly for Xenopus laevis...
- DANIEL SOLEYMAN ROKHSAR; Fiscal Year: 2016..here to continue improvement of both the short range, and long range (chromosome level) assemblies of Xenopus tropicalis and Xenopus laevis...
- Genomic survey of cis-regulatory element function by high-throughput transgenesisRobert M Grainger; Fiscal Year: 2012Our aim is to develop Xenopus tropicalis as a robust, relevant and rapid vertebrate model system for the analysis of the regulatory functions conferred by gene-specific conserved non-coding elements (CNEs)...
- Alan M Lambowitz; Fiscal Year: 2016..4) To use Xenopus tropicalis to further develop methods for using group II introns for gene targeting in eukaryotes via sperm DNA ..
- Rebecca W Heald; Fiscal Year: 2015..First, we can compare Xenopus laevis to the smaller, related species Xenopus tropicalis, which lays smaller eggs and has proportionally smaller cells throughout development...
- Gert Jan C Veenstra; Fiscal Year: 2015..Embryos of the amphibian Xenopus tropicalis represent an excellent model system for development and differentiation...
- CSHL Cell and Developmental Biology of XenopusTERRI I GRODZICKER; Fiscal Year: 2013..extensive laboratory exposure to the biology and manipulation of embryos from the frogs Xenopus laevis and Xenopus tropicalis. This course prepares students for independent research in the cell, genetic, and molecular analysis of ..
- Julie C Baker; Fiscal Year: 2015..In this grant, we use Xenopus laevis and Xenopus tropicalis to address the involvement of the chromatin state and its interface with the Nodal signaling factor, smad2/3,..
- Deciphering Principles of Regulatory GenomicsGabriela G Loots; Fiscal Year: 2010..bioinformatics and comparative genomics with molecular biology expertise in a new model organism, the frog Xenopus tropicalis, to determine the genomic encryption of tissue-specific gene regulation, with emphasis on skeletal muscle ..
- Group II Intron-Based Gene Targeting Methods for XenopusAlan Lambowitz; Fiscal Year: 2009..We propose to develop efficient group II intron-based gene targeting methods for Xenopus laevis and Xenopus tropicalis. Mobile group II introns insert site-specifically into DNA target sites by a remarkable mechanism in which ..
- Characterization of neural crest gene expression using a new transgenic Xenopus mShuo Wei; Fiscal Year: 2013..Toward this objective a transgenic Xenopus tropicalis line that expresses fluorescent reporter in the neural crest lineage (the snail2-egfp line) has been ..
- Developing transposon methods for insertional mutagenesis in XenopusMustafa K Khokha; Fiscal Year: 2010..The main goal of this proposal is to develop transposon tools in order to mutagenize the genome of Xenopus tropicalis. Recently, we have developed genetic analysis in Xenopus which is an exciting new avenue for studying gene ..
- Transcriptional regulation of liver specification in Xenopus tropicalisANDREA ELIZABETH WILLS; Fiscal Year: 2012..Therefore, the proposed research will be carried out in the frog Xenopus tropicalis, which has large numbers of readily manipulated embryos ideal for rapid screening and biochemical ..
- Characterization and cloning of X. tropicalis Craniofacial MutantsMustafa K Khokha; Fiscal Year: 2012..In this proposal, we will investigate craniofacial development in an emerging model system, Xenopus tropicalis. During a recent forward genetic screen, we identified two mutants, jaws and jawbreaker, that exhibit a ..
- Genetic Analysis of Inner Ear Development in tropicalisRichard M Harland; Fiscal Year: 2010..underlying molecular and genetic interactions, we are undertaking a forward genetic screen in the amphibian Xenopus tropicalis, a recently introduced genetic model animal...
- Craniofacial and cardiac development in Xenopus: A genetic approachMustafa K Khokha; Fiscal Year: 2013..To this end, we will use the model organism Xenopus tropicalis to conduct forward and reverse genetics screens to generate animal for human disease states and to identify ..
- Homologous recombination in Xenopus and ZebrafishSigrid Reinsch; Fiscal Year: 2005..2) The investigators will target a chromosomal Green Fluorescent Protein (GFP) transgene in Xenopus tropicalis embryos to generate visually screenable loss of function phenotypes...
- Genetic map of the Xenopus tropicalis genomeDan Wells; Fiscal Year: 2006The proposed work will generate key resources for genetic and molecular studies of the amphibian Xenopus tropicalis. Xenopus tropicalis is an emerging model system for the genetic analysis of vertebrate development, combining the many ..
- Genetic Screens in Xenopus tropicalisDEREK STEMPLE; Fiscal Year: 2004Two pilot genetic screens using the diploid amphibian Xenopus tropicalis are proposed...
- Toxicant Target Genes in Xenopus and Zebrafish EmbryosJeremy Green; Fiscal Year: 2004..g., neural tube closure). A third species, Xenopus tropicalis (X. tropicalis) is a cousin of X. laevis, is suitable for genetics but is novel as an experimental species...
- Development of the Acoustico-Vestibular SystemELBA SERRANO; Fiscal Year: 2005..Results of these investigations also may be valuable in design of treatments for hereditary and environmentally-induced sensory disorders of hearing and balance. ..
- Development of the Vertebrate Primary MouthHazel Sive; Fiscal Year: 2007..are to define the molecular mechanisms involved in vertebrate primary mouth formation, using the frog Xenopus tropicalis as a model...
- VEGETALLY LOCALIZED TRANSCRIPTSLAURENCE ETKIN; Fiscal Year: 2000..has cloned a family of genes that code for interspersed repeat transcripts from Xenopus laevis (xlsirts) and Xenopus tropicalis (xtsirts)...
- New vertebrate model organism cDNA librariesBruce Blumberg; Fiscal Year: 2003..available a set of normalized, full-length cDNA libraries from the emerging vertebrate model organism Xenopus tropicalis. These libraries will be constructed identically and in the same expression vector capable of directing ..
- CELL AND DEVELOPMENTAL BIOLOGY OF XENOPUSTERRI GRODZICKER; Fiscal Year: 2003..assays; 7) Oligonucleotide antisense techniques for "Knock- out" of maternal molecules; 8) Preparation and use of cell cycle extracts for construction of transgenic embryos; and 9) Use of Xenopus tropicalis as a genetic model.
- NEW STRATEGIES FOR UNDERSTANDING FOREBRAIN DEVELOPMENTRobert Grainger; Fiscal Year: 2002..amphibian studies in the genetically tractable animal (it's diploid and has a short generation time) Xenopus tropicalis. The objective of the current research proposal is technological (to construct transgenic animals in which ..
- ROLE OF NON-CLASSICAL MHC CLASS I AND HSPs IN IMMUNITYJacques Robert; Fiscal Year: 2009..Do hsp70 and gp96 generate similar anti-tumor CCU-CTL effectors? Aim 3. How important is the hsp-generated CCU-CTL responses in tumor immunity in vivo? Aim 4. Do CCU-CTLs interact with class Ib molecules? ..
- Genetic Control of Early Retinal DevelopmentRobert M Grainger; Fiscal Year: 2010..Third, we will examine the regulation of and interactions among a critical group of transcription factors essential for retina formation in order to ascertain their roles in the determination mechanism. ..
- AMPHIBIAN MODEL FOR VERTEBRATE DEVELOPMENTAL GENETICSRobert Grainger; Fiscal Year: 2008..tropicalis. This project should complement the growing genomic resources for X. tropicalis which include a genome project to commence in the summer of 2002. ..
- GENETIC CONTROL OF LENS FORMATIONRobert Grainger; Fiscal Year: 2001..The final goal is to test the function of transcriptional regulatory genes in controlling lens competence, bias and specification in Xenopus embryos. ..
- INDUCTION OF THE EMBRYONIC LENSRobert Grainger; Fiscal Year: 2005..This proposal also utilizes new technology we have developed for the amphibian Xenopus tropicalis which has a diploid genome and short life cycle that make it far more suitable than Xenopus laevis for ..
- Proteomics of Egg Cortical GranulesLEANN LINDSAY; Fiscal Year: 2003..This approach will identify potential molecules important in egg extracellular matrix modifications, which will be the subject of future investigations. ..
- Insertional Mutagenesis Strategies in Xenopus tropicalisPaul Mead; Fiscal Year: 2006..The proposed study will provide valuable insight into the biology of hematopoiesis in both normal and disease states. ..
- Functions of Mammalian thioredoxin reductasesVADIM GLADYSHEV; Fiscal Year: 2009..iii) What are the determinants for preferential supply of thioredoxin reductases with selenium? We will examine elements in thioredoxin reductase genes responsible for this effect. ..
- Xenbase: a Xenopus Model Organism DatabasePETER VIZE; Fiscal Year: 2009..abstract_text> ..
- Antisense Mediated Suppression of Dystrophin MutationsMichael Howard; Fiscal Year: 2007..unreadable] [unreadable]..
- Selenoprotein Synthesis: Redefinition of Selenocysteine-encoding UGA CodonsMichael T Howard; Fiscal Year: 2010....
- Tol2-mediated gene and enhancer trapping in Xenopus tropicalisPaul E Mead; Fiscal Year: 2010..We are currently characterizing the novel integration events in the progeny from the other remobilized F2 frogs. We anticipate submitting a manuscript describing this data soon. ..
- Analysis of Noelin, a Neural Crest Competence FactorMarianne Bronner Fraser; Fiscal Year: 2005..3) Generate and characterize the phenotype of Noelin-1 null mutant. (4) Examine the environmental regulation of Noelin-1 expression. ..
- INDUCTION OF THE NEURAL CRESTMarianne Bronner Fraser; Fiscal Year: 2008..3. Examine the possible role of Notch signaling in cell fate decisions within the neural folds as cells choose between neural crest, neural tube or epidermal fates. ..
- ROLE OF ID2 IN CRANIOFACIAL DEVELOPMENTMarianne Bronner Fraser; Fiscal Year: 2004..2. examine the function of E12 in neural crest development and craniofacial patterning. 3. identify and characterize an achaete-scute homolog(s) that potentially interacts with Id2/E proteins. ..
- Molecular analysis of neural crest migrationMarianne Bronner Fraser; Fiscal Year: 2007..2. The function of the a5 subunit of laminin in early neural crest development. 3. The function of a novel chemokine in neural crest migration. 4. The function of this novel chemokine in limb development. ..
- ECTODERMAL PLACODE DEVELOPMENT INTO CRANIAL GANGLIAMarianne Bronner Fraser; Fiscal Year: 2003..2) examine the induction and development of the nodose placode. 3) identify molecular markers for other epibranchial placodes. 4) examine the interrelationships of the neural crest and placodes. ..
- Meeting: Development of the Spinal Cord and Neural CrestMarianne Bronner Fraser; Fiscal Year: 2002....
- INDUCTION OF THE NEURAL CRESTMarianne Bronner Fraser; Fiscal Year: 2001..3. Determine the competence of ectoderm and neural plate to assume a neural crest fate. 4. Determine the competence of neural crest cells to assume a neural tube fate after transplantation into the ventral neural tube. ..
- SENSORY RECALIBRATION OF MOTOR OUTPUTHarold Zakon; Fiscal Year: 2004..abstract_text> ..
- Cochlear Type II Afferents and Nociception in the Inner*Jaime Garcia Anoveros; Fiscal Year: 2004....
- Gordon Research Conference on NeuroethologyHarold Zakon; Fiscal Year: 2002..Our goal is for broad intellectual and technical cross-fertilization between these two traditions. ..
- A Genetic Approach to Organogenesis in XenopusFrank Conlon; Fiscal Year: 2006..to determine the precise endogenous role for SHP-2 and TBX5 in early organ development in the diploid frog Xenopus tropicalis (X. tropicalis)...
- Mechanism of cytochrome P450 uncoupling and inactivationJARED GOLDSTONE; Fiscal Year: 2005..Recently identified AhR-agonistic persistent pollutants, such as polybrominated diphenyl ethers will also be investigated. ..
- Genetic methods using the Tol2 transposable elementKoichi Kawakami; Fiscal Year: 2006..abstract_text> ..
- Requirements for the FGF/MAPK in early heart developmentFrank Conlon; Fiscal Year: 2007..abstract_text> ..
- Antibacterial peptidoglycan recognition proteinsRoman Dziarski; Fiscal Year: 2007..abstract_text> ..
- MOLECULAR AND CELLULAR BASIS OF LENS DEVELOPMENTJonathan J Henry; Fiscal Year: 2010....
- HORMONAL MODULATION OF A COMMUNICATION SIGNALHarold Zakon; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENTAnthony B Firulli; Fiscal Year: 2010..The understanding gained from this proposal will add significant insight into the molecular mechanisms that drive heart formation and go awry in human disease. ..
- THYROID HORMONE CONTROL OF A GENE EXPRESSION NETWORKJ Furlow; Fiscal Year: 2008..abstract_text> ..
- Specificity and Spatial Dynamics of Cell Signaling: The*Qing Nie; Fiscal Year: 2008..New mathematical theories and numerical algorithms will have to be developed for the analysis and simulations. ..
- Role of fetal TCDD-activited AHR in adult heart diseaseCraig Tomlinson; Fiscal Year: 2008..unreadable] [unreadable]..
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