western clawed frog

Summary

Alias: Silurana tropicalis, Xenopus tropicalis, Xenopus (Silurana) tropicalis, Silurana tropicalis Gray, 1864, Xenopus laevis tropicalis, Xenopus tropicalis (Gray, 1864)

Top Publications

  1. pmc Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane
    E Monti
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Via Olgettina 58, 20132 Milan, Italy and Department of Biomedical Science and Biotechnology, University of Brescia, Via Valsabbina 19, 25123 Brescia, Italy
    Biochem J 349:343-51. 2000
  2. ncbi Depletion of the cell-cycle inhibitor p27(Xic1) impairs neuronal differentiation and increases the number of ElrC(+) progenitor cells in Xenopus tropicalis
    Samantha Carruthers
    Wellcome Trust Cancer Research UK Institute, Tennis Court Road, Cambridge CB2 1QR, UK
    Mech Dev 120:607-16. 2003
  3. ncbi Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family
    E Monti
    Department of Biomedical Science and Biotechnology, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Genomics 83:445-53. 2004
  4. ncbi Expression of Xenopus tropicalis noggin1 and noggin2 in early development: two noggin genes in a tetrapod
    Russell B Fletcher
    Division of Genetics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Gene Expr Patterns 5:225-30. 2004
  5. pmc Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codons
    Michael T Howard
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    EMBO J 24:1596-607. 2005
  6. ncbi Specific expression of olfactory binding protein in the aerial olfactory cavity of adult and developing Xenopus
    Julie Millery
    Centre Européen des Sciences du Goût, CNRS UMR 5170, 15 rue Hugues Picardet, 21000 Dijon, France
    Eur J Neurosci 22:1389-99. 2005
  7. ncbi Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
    Guillermo Barreto
    Division of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 445:671-5. 2007
  8. pmc BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo
    Jeffrey K Huang
    Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK
    BMC Dev Biol 7:59. 2007
  9. pmc FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation
    Martin Roth
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Development 137:1553-62. 2010
  10. pmc Specific histone lysine 4 methylation patterns define TR-binding capacity and differentiate direct T3 responses
    Patrice Bilesimo
    Museum national d histoire naturelle, Départment Régulation Développement et Diversité Moléculaire, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique, Evolution des Regulations Endocriniennes, 75231 Paris Cedex 05, France
    Mol Endocrinol 25:225-37. 2011

Research Grants

  1. Insertional mutagenesis screen for otic genes in Xenopus
    Sigrid Reinsch; Fiscal Year: 2003
  2. Genetic Analysis of Silurana Tropicalis Development
    Richard Harland; Fiscal Year: 2005
  3. Richard M Harland; Fiscal Year: 2015
  4. A genome assembly for Xenopus laevis
    DANIEL SOLEYMAN ROKHSAR; Fiscal Year: 2013
  5. DANIEL SOLEYMAN ROKHSAR; Fiscal Year: 2016
  6. Genomic survey of cis-regulatory element function by high-throughput transgenesis
    Robert M Grainger; Fiscal Year: 2012
  7. Alan M Lambowitz; Fiscal Year: 2016
  8. Rebecca W Heald; Fiscal Year: 2015
  9. Gert Jan C Veenstra; Fiscal Year: 2015
  10. CSHL Cell and Developmental Biology of Xenopus
    TERRI I GRODZICKER; Fiscal Year: 2013

Patents

  1. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
  2. O-CADHERIN AS A BIOMARKER FOR CIRCULATING TUMOR CELLS
  3. COMPOSITIONS AND METHODS MODULATING MG29 FOR THE TREATMENT OF DIABETES
  4. C1Q/TNF-RELATED PROTEIN 12 AND COMPOSITIONS AND METHODS OF USING SAME
  5. FUNCTIONAL EXPRESSION OF BACTERIAL MAJOR FACILITATOR SUPERFAMILY (SFM) GENE IN MAIZE TO IMPROVE AGRONOMIC TRAITS AND GRAIN YIELD
  6. Polypeptide Vaccine
  7. TIKI INHIBITORS
  8. DETECTION METHODS
  9. DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES
  10. MICRO-RNAS THAT CONTROL MYOSIN EXPRESSION AND MYOFIBER IDENTITY

Detail Information

Publications273 found, 100 shown here

  1. pmc Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane
    E Monti
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Via Olgettina 58, 20132 Milan, Italy and Department of Biomedical Science and Biotechnology, University of Brescia, Via Valsabbina 19, 25123 Brescia, Italy
    Biochem J 349:343-51. 2000
    ..8. Immunofluorescence staining of the transfected COS7 cells demonstrated the protein's localization in the plasma membrane...
  2. ncbi Depletion of the cell-cycle inhibitor p27(Xic1) impairs neuronal differentiation and increases the number of ElrC(+) progenitor cells in Xenopus tropicalis
    Samantha Carruthers
    Wellcome Trust Cancer Research UK Institute, Tennis Court Road, Cambridge CB2 1QR, UK
    Mech Dev 120:607-16. 2003
    ..For such knockdown studies, Xenopus tropicalis is a better model system than Xenopus laevis, since it has a diploid genome. Indeed, while X...
  3. ncbi Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family
    E Monti
    Department of Biomedical Science and Biotechnology, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Genomics 83:445-53. 2004
    ..Immunofluorescence staining and Western blot analysis demonstrated the association of NEU4 with the inner cell membranes...
  4. ncbi Expression of Xenopus tropicalis noggin1 and noggin2 in early development: two noggin genes in a tetrapod
    Russell B Fletcher
    Division of Genetics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Gene Expr Patterns 5:225-30. 2004
    We report the identification of two distinct noggin genes in the tetrapod Xenopus tropicalis. Noggin functions to antagonize BMP signaling in many developmental contexts, and much work has explored its role in early vertebrate development...
  5. pmc Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codons
    Michael T Howard
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    EMBO J 24:1596-607. 2005
    ..Sequences capable of forming strong RNA structures were also identified 3' adjacent to, or near, selenocysteine-encoding UGA codons in the Sps2, SelH, SelO, and SelT selenoprotein genes...
  6. ncbi Specific expression of olfactory binding protein in the aerial olfactory cavity of adult and developing Xenopus
    Julie Millery
    Centre Européen des Sciences du Goût, CNRS UMR 5170, 15 rue Hugues Picardet, 21000 Dijon, France
    Eur J Neurosci 22:1389-99. 2005
    ..We therefore purified and cloned OBPs in two Xenopus species. Xenopus laevis OBP (XlaeOBP) and Xenopus tropicalis OBP (XtroOBP) exhibit 158 and 160 amino acids, respectively, sharing 89 residues...
  7. ncbi Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
    Guillermo Barreto
    Division of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 445:671-5. 2007
    ..Active demethylation occurs by DNA repair and Gadd45a interacts with and requires the DNA repair endonuclease XPG. We conclude that Gadd45a relieves epigenetic gene silencing by promoting DNA repair, which erases methylation marks...
  8. pmc BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo
    Jeffrey K Huang
    Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK
    BMC Dev Biol 7:59. 2007
    ..Brain derived neurotrophic factor, BDNF is known to stimulate axon outgrowth and branching. The goal of this study is to determine whether BDNF functions as the proposed target recognition signal in the Xenopus cement gland...
  9. pmc FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation
    Martin Roth
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Development 137:1553-62. 2010
    ..Here, we show that interaction of FoxG1 with TLE2, a Xenopus tropicalis co-repressor of the Groucho/TLE family, is crucial for regulating the early activity of FoxG1...
  10. pmc Specific histone lysine 4 methylation patterns define TR-binding capacity and differentiate direct T3 responses
    Patrice Bilesimo
    Museum national d histoire naturelle, Départment Régulation Développement et Diversité Moléculaire, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique, Evolution des Regulations Endocriniennes, 75231 Paris Cedex 05, France
    Mol Endocrinol 25:225-37. 2011
    ..Reverse transcription-real-time quantitative PCR analysis on Xenopus tropicalis tadpole brain and tail fin showed differences in expression levels in premetamorphic tadpoles (lower for TH/..
  11. pmc Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning
    Khalid A Fakhro
    Department of Genetics, The Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:2915-20. 2011
    ..These effects were specific, because 0 of 13 control genes from rare Htx or control copy number variations produced significant LR abnormalities (P = 0.001). These findings identify genes not previously implicated in LR patterning...
  12. pmc Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops
    Edoardo Giacopuzzi
    Department of Biomedical Sciences and Biotechnology, Unit of Biology and Genetics, University of Brescia, Viale Europa 11, Brescia 25123, Italy
    BMC Biochem 12:45. 2011
    ..These features prompted us to extend our studies on this protein family in birds, to get insights on the evolution of this class of glycohydrolases...
  13. doi The permeability of reconstituted nuclear pores provides direct evidence for the selective phase model
    Bastian B Hülsmann
    Abteilung Zelluläre Logistik, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, D 37077 Gottingen, Germany
    Cell 150:738-51. 2012
    ..Our data exclude alternative models that are based solely on an interaction between the FG repeats and NTRs and indicate that the barrier is formed by a sieve-like FG hydrogel...
  14. ncbi Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes
    S Knochel
    Abteilung Biochemie, Universitat Ulm, Albert Einstein Allee 11, D 89081, Ulm, Germany
    Mech Dev 109:79-82. 2001
    The Xenopus tropicalis BMP-2 and BMP-4 genes have been cloned and sequenced. A comparison with the corresponding genes from X. laevis reveals that the BMP-4 genes are conserved at a higher extent than the BMP-2 genes...
  15. ncbi Cloning and expression of the Cdx family from the frog Xenopus tropicalis
    John S Reece-Hoyes
    Department of Biology, University of York, York, United Kingdom
    Dev Dyn 223:134-40. 2002
    ..In this study, we report the cloning of cDNAs from the Cdx genes of the amphibian Xenopus tropicalis. Xenopus tropicalis is a diploid species, related to the commonly used laboratory animal Xenopus laevis, and ..
  16. ncbi FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation
    Jeremy M Sivak
    The Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge
    Dev Cell 8:689-701. 2005
    ..We identified two genes for each family in Xenopus tropicalis: Xtsprouty1, Xtsprouty2, Xtspred1, and Xtspred2...
  17. pmc Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysis
    Ana C Fierro
    CNRS UMR 8080, F 91405 Orsay, France
    BMC Genomics 8:118. 2007
    The western African clawed frog Xenopus tropicalis is an anuran amphibian species now used as model in vertebrate comparative genomics. It provides the same advantages as Xenopus laevis but is diploid and has a smaller genome of 1.7 Gbp...
  18. pmc Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio)
    Marta Manzoni
    Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Biochem J 408:395-406. 2007
    ..Overall, the redundancy of sialidases together with their expression profile and their activity exerted on gangliosides of living cells indicate the biological relevance of this class of enzymes in zebrafish...
  19. doi Xenopus tropicalis allurin: expression, purification, and characterization of a sperm chemoattractant that exhibits cross-species activity
    Lindsey A Burnett
    Molecular and Cellular Biology Program, School of Life Sciences, Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287 4501, USA
    Dev Biol 316:408-16. 2008
    ..Here we report identification, purification, and characterization of Xenopus tropicalis (Xt) allurin, a homologous protein in X. tropicalis...
  20. pmc Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6
    Anita Abu-Daya
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Dev Biol 336:20-9. 2009
    ..Forward genetic screens in Xenopus tropicalis have identified more than 80 mutations affecting diverse developmental processes, including cardiac ..
  21. doi Cloning and expression analysis of the anterior parahox genes, Gsh1 and Gsh2 from Xenopus tropicalis
    Jean C Illes
    Department of Biology, University of York, York, United Kingdom
    Dev Dyn 238:194-203. 2009
    ..We report the cloning of two Gsx genes, Gsh1 and Gsh2, from the frog Xenopus tropicalis. We demonstrate the existence of a single, intact Xenopus ParaHox cluster, containing Gsh1, Pdx, and Cdx2, ..
  22. ncbi Pattern and morphogenesis of presumptive superficial mesoderm in two closely related species, Xenopus laevis and Xenopus tropicalis
    David R Shook
    Department of Biology, University of Virginia, Gilmer Hall, Charlottesville, VA 22903, USA
    Dev Biol 270:163-85. 2004
    ..superficial component of the presumptive mesoderm ingresses into the underlying deep mesenchymal layer in Xenopus tropicalis and extend our previous findings for Xenopus laevis...
  23. ncbi Cornea-lens transdifferentiation in the anuran, Xenopus tropicalis
    J J Henry
    Department of Cell and Structural Biology, University of Illinois, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Dev Genes Evol 211:377-87. 2001
    ..These findings are discussed in terms of the evolution of this developmental process within the anurans...
  24. ncbi Excision of the Tol2 transposable element of the medaka fish Oryzias latipes in Xenopus laevis and Xenopus tropicalis
    Koichi Kawakami
    Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Gene 338:93-8. 2004
    ..Our present study suggests that the Tol2 transposon system should be used as a novel genetic tool to develop transgenesis and mutagenesis methods in Xenopus...
  25. ncbi Comparative sensitivity of Xenopus tropicalis and Xenopus laevis as test species for the FETAX model
    Douglas J Fort
    Fort Environmental Laboratories, 1414 South Sangre, Stillwater, OK 74074, USA
    J Appl Toxicol 24:443-57. 2004
    The use of Xenopus tropicalis as an alternative test species for the Frog Embryo Teratogenesis Assay-Xenopus (FETAX) model was evaluated...
  26. ncbi Experimental analysis of lens-forming capacity in Xenopus borealis larvae
    Sergio Filoni
    Department of Biology, Tor Vergata University, Roma, Italy
    J Exp Zool A Comp Exp Biol 305:538-50. 2006
    ..anuran amphibians known to have the capacity to regenerate a lens after lentectomy were Xenopus laevis and Xenopus tropicalis. This regeneration process occurs during the larval life through transdifferentiation of the outer cornea ..
  27. ncbi Defining a large set of full-length clones from a Xenopus tropicalis EST project
    Michael J Gilchrist
    Wellcome Trust Cancer Research UK Gurdon Institute, Cambridge CB21QR, UK
    Dev Biol 271:498-516. 2004
    ..Xenopus, and in particular the diploid Xenopus tropicalis, is also ideal for functional genomics...
  28. ncbi Cloning and expression of xP1-L, a new marker gene for larval surface mucous cells of tadpole stomach in Xenopus laevis
    Masayuki Ikuzawa
    Life Science Institute, Sophia University, Tokyo 102 8554, Japan
    Gene Expr Patterns 8:12-8. 2007
    ..A new gene homologous to xP1 was obtained and named xP1-L. In the genome database of Silurana tropicalis, we found a homologue of xP1-L and named it stP1-L...
  29. ncbi Regulation of the G2/M transition in oocytes of xenopus tropicalis
    Jennifer S Stanford
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 260:438-48. 2003
    ..Oocytes of Xenopus tropicalis offer several practical advantages over those of X...
  30. ncbi Ancestral organization of the MHC revealed in the amphibian Xenopus
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland, 655 West Baltimore Street, BRB13 009, Baltimore, MD 21201, USA
    J Immunol 176:3674-85. 2006
    With the advent of the Xenopus tropicalis genome project, we analyzed scaffolds containing MHC genes. On eight scaffolds encompassing 3.65 Mbp, 122 MHC genes were found of which 110 genes were annotated...
  31. pmc Xenopus microRNA genes are predominantly located within introns and are differentially expressed in adult frog tissues via post-transcriptional regulation
    Guo Qing Tang
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695 7622, USA
    Genome Res 18:104-12. 2008
    ..Xenopus genome databases using known human pre-miRNAs as query sequences, more than 300 genes encoding 142 Xenopus tropicalis miRNAs were identified...
  32. doi Regulatory elements of Xenopus col2a1 drive cartilaginous gene expression in transgenic frogs
    Ryan Kerney
    Biology Department, Dalhousie University, Halifax, NS, Canada
    Int J Dev Biol 54:141-50. 2010
    ..These constructs contain a portion of the Xenopus tropicalis col2a1 intron, which aligns to a cartilage-specific intronic enhancer that has been well characterized in ..
  33. doi Structural and biological properties of erythropoietin in Xenopus laevis
    Nami Nogawa-Kosaka
    Graduate School of Advanced Science and Engineering, Center for Advanced Life and Medical Science, Waseda University, Tokyo, Japan
    Exp Hematol 38:363-72. 2010
    ..We aimed to investigate the structural and functional conservation of the EPO-EPOR system in amphibian erythropoiesis, using Xenopus laevis as a model...
  34. ncbi A third striated muscle actin gene is expressed during early development in the amphibian Xenopus laevis
    T Mohun
    Cancer Research Campaign, Department of Zoology, Cambridge, England
    J Mol Biol 202:67-76. 1988
    ..The related, diploid species, Xenopus tropicalis, possesses a single copy of the alpha 3 gene and its transcript is similarly conserved in nucleotide ..
  35. doi Clotrimazole exposure modulates aromatase activity in gonads and brain during gonadal differentiation in Xenopus tropicalis frogs
    Irina Gyllenhammar
    Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala CRU, Norbyvägen 18 A, 75236 Uppsala, Sweden
    Aquat Toxicol 91:102-9. 2009
    ..larval exposure to clotrimazole on aromatase activity in brain and gonads, and on gonadal differentiation in Xenopus tropicalis frogs...
  36. ncbi Isolation, sequence identification and expression profile of three novel genes Rab2A, Rab3A and Rab7A from Black-boned sheep (Ovis aries)
    Y D He
    Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China
    Mol Biol (Mosk) 44:20-7. 2010
    ..domain and is very similar to the Rab3A proteins of four species--cattle (99%), African clawed frog (99%), Western clawed frog (98%) and zebrafish (95%)...
  37. ncbi Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family
    Jared V Goldstone
    Department of Biology, Woods Hole Oceanographic Institution, Woods Hole
    Mol Biol Evol 24:2619-31. 2007
    ..tunicates and echinoderms), and several new CYP1 genes in vertebrates (chicken, Gallus gallus and frog, Xenopus tropicalis)...
  38. pmc Evolution of serum albumin intron-1 is shaped by a 5' truncated non-long terminal repeat retrotransposon in western Palearctic water frogs (Neobatrachia)
    Jörg Plötner
    Museum für Naturkunde, Leibniz Institut für Evolutions und Biodiversitätsforschung an der Humboldt Universität zu Berlin, Invalidenstrasse 43, 10115 Berlin, Germany
    Mol Phylogenet Evol 53:784-91. 2009
    ..the highly conserved 3' untranslated region (3' UTR), RanaCR1-like elements occur also in the genome of Xenopus tropicalis and Rana temporaria. Unlike other CR1 elements, RanaCR1 contains a CA microsatellite in its 3' UTR...
  39. pmc Phylogenetic analysis of the tenascin gene family: evidence of origin early in the chordate lineage
    R P Tucker
    Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA 95616, USA
    BMC Evol Biol 6:60. 2006
    ..the urochordate Ciona intestinalis, the pufferfish Tetraodon nigroviridis and Takifugu rubripes and the frog Xenopus tropicalis were identified and their gene organization and predicted protein products compared with the previously ..
  40. ncbi Development of biomarkers of endocrine disrupting activity in emerging amphibian model, Silurana (Xenopus) tropicalis
    Minoru Takase
    Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, 1 3 1 Kagamiyama, Higashi Hiroshima, Hiroshima 739 8526, Japan
    Environ Sci 14:285-96. 2007
    ....
  41. doi Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval development
    Valérie S Langlois
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    Gen Comp Endocrinol 166:417-27. 2010
    ..We conclude that cyp19 and srd5 beta are active in early embryogenesis and larval development in Silurana tropicalis and their inhibition affected transcription of genes associated with the thyroid and reproductive axes.
  42. ncbi [Cloning of silkworm 3-hydroxyisobutyrate dehydrogenase gene and its expression patterns analysis in simulated weightless environment]
    Zongcheng Tian
    Key Laboratory for Space Biosciences and Biotechnology, Institute of Special Environmental Biophysics, Faculty of Life Sciences, Northwestern Polytechnical University, Xi an 710072, China
    Sheng Wu Gong Cheng Xue Bao 24:2041-8. 2008
    ..similarities of hibadh between silkworm and Burkholderia ambifaria, Drosophila melanogaster, Apis mellifera, Xenopus tropicalis, Mus musculus, Homo sapiens were 46%, 43%, 48%, 44%, 45%, 45%, respectively...
  43. doi Development of potent anti-infective agents from Silurana tropicalis: conformational analysis of the amphipathic, alpha-helical antimicrobial peptide XT-7 and its non-haemolytic analogue [G4K]XT-7
    Anusha P Subasinghage
    UCD School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, SEC Strategic Research Cluster, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Biochim Biophys Acta 1804:1020-8. 2010
    ..NH(2)) is a cationic, leucine-rich peptide, first isolated from skin secretions of the frog, Silurana tropicalis (Pipidae)...
  44. pmc Evolution of pharmacologic specificity in the pregnane X receptor
    Sean Ekins
    Collaborations in Chemistry, Inc, Jenkintown, PA, USA
    BMC Evol Biol 8:103. 2008
    ..The ligand activation properties of the Western clawed frog (Xenopus tropicalis) PXR and that of a putative vitamin D receptor (VDR)/PXR cloned in this study from the ..
  45. pmc Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene
    Alasdair J Edgar
    Department of Craniofacial Development, King s College, London, UK
    BMC Genomics 6:32. 2005
    ..Low levels of TA enzymatic activity have been found in vertebrates. It has been suggested that any detectable activity is due to serine hydroxymethyltransferase and that mammals lack a genuine threonine aldolase...
  46. doi Genotyping sex in the amphibian, Xenopus (Silurana) tropicalis, for endocrine disruptor bioassays
    Allen W Olmstead
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, United States
    Aquat Toxicol 98:60-6. 2010
    ..This approach to identifying sex-linked markers and developing sex genotyping methods is applicable to other species with genetic sex determination...
  47. ncbi Evaluation of the developmental and reproductive toxicity of methoxychlor using an anuran (Xenopus tropicalis) chronic exposure model
    Douglas J Fort
    Fort Environmental Laboratories, 1414 South Sangre Road, Stillwater, Oklahoma 74074, USA
    Toxicol Sci 81:443-53. 2004
    ..These studies add to the standardization and validation of a useful amphibian test methods capable of evaluating both reproductive and developmental effects of potential endocrine disrupting chemicals over a life cycle exposure...
  48. ncbi Evolution of new hormone function: loss and gain of a receptor
    D M Irwin
    Department of Laboratory Medicine and Pathobiology, Banting and Best Diabetes Centre, University of Toronto, 100 College St, Toronto, Ontario, Canada M5G lL5
    J Hered 96:205-11. 2005
    ..receptors for proglucagon-derived peptides from the genomes of two fish (pufferfish and zebrafish), a frog (Xenopus tropicalis), and a bird (chicken)...
  49. doi Sex reversal of the amphibian, Xenopus tropicalis, following larval exposure to an aromatase inhibitor
    Allen W Olmstead
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, MN, USA
    Aquat Toxicol 91:143-50. 2009
    ..exposure to the aromatase inhibitor, fadrozole, during the larval development of the tropical clawed frog, Xenopus tropicalis, would result in masculinization of the developing female gonad...
  50. ncbi Evolution of thermoTRP ion channel homologs in vertebrates
    Shigeru Saito
    Laboratory of Bioscience, Faculty of Engineering, Iwate University, 4 3 5 Ueda, Morioka 020 8551, Japan
    Physiol Genomics 27:219-30. 2006
    ..searches for mammalian thermoTRP gene homologs in the draft genome sequences of chicken (Gallus gallus), western clawed frog (Xenopus tropicalis), zebrafish (Danio rerio), and pufferfish (Fugu rubripes)...
  51. pmc Identification and correction of abnormal, incomplete and mispredicted proteins in public databases
    Alinda Nagy
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, H 1113 Budapest, Hungary
    BMC Bioinformatics 9:353. 2008
    ....
  52. doi Acute toxicity of rice paddy herbicides simetryn, mefenacet, and thiobencarb to Silurana tropicalis tadpoles
    Masahiro Saka
    Kyoto Prefectural Institute of Public Health and Environment, Murakamicho 395, Fushimi ku, Kyoto 612 8369, Japan
    Ecotoxicol Environ Saf 73:1165-9. 2010
    ..simetryn, mefenacet, and thiobencarb to amphibians by conducting acute toxicity tests with tadpoles of Silurana tropicalis, which has attracted as a new model species instead of Xenopus laevis...
  53. pmc Regulation of thyroid hormone-, oestrogen- and androgen-related genes by triiodothyronine in the brain of Silurana tropicalis
    Paula Duarte-Guterman
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    J Neuroendocrinol 22:1023-31. 2010
    ..Finally, we have identified sex steroid-related genes that are responsive to T3, providing additional evidence of crosstalk between THs and sex steroids in the tadpole brain...
  54. pmc Haptoglobin, a hemoglobin-binding plasma protein, is present in bony fish and mammals but not in frog and chicken
    Krzysztof B Wicher
    Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden
    Proc Natl Acad Sci U S A 103:4168-73. 2006
    ..Surprisingly, we found that both chicken (Gallus gallus) and the Western clawed frog (Xenopus tropicalis) lack the Hp gene...
  55. ncbi HnRNP A3 genes and pseudogenes in the vertebrate genomes
    Aleksandr V Makeyev
    Department of Genetics and Development, Columbia University, NYC, NY 10032, USA
    J Exp Zool A Comp Exp Biol 303:259-71. 2005
    ..In addition, we have found and compared hnRNP A3 orthologous genes in Gallus gallus, Xenopus tropicalis, and Danio rerio...
  56. ncbi Evolutionary selection pressure and family relationships among connexin genes
    Véronique Cruciani
    Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Biol Chem 388:253-64. 2007
    ..The conserved domains of connexins were collected from chicken, Xenopus tropicalis, zebrafish, pufferfish, green spotted pufferfish, Ciona intestinalis and Halocynthia pyriformis (two ..
  57. ncbi Patterns of vertebrate isochore evolution revealed by comparison of expressed mammalian, avian, and crocodilian genes
    Jena L Chojnowski
    Department of Zoology, University of Florida, Gainesville, FL 32611, USA
    J Mol Evol 65:259-66. 2007
    ..The alligator ESTs were assembled and aligned with their human, mouse, chicken, and western clawed frog orthologs, resulting in 366 alignments...
  58. doi Preparation of Xenopus tropicalis whole chromosome painting probes using laser microdissection and reconstruction of X. laevis tetraploid karyotype by Zoo-FISH
    Vladimir Krylov
    Faculty of Science, Charles University in Prague, Vinicna 7, 128 44 Prague 2, Czech Republic
    Chromosome Res 18:431-9. 2010
    ..In addition, the observed translocation events could explain the origin of individuals with 18 chromosomes in diploid karyotypes, probably extinct after the genesis of the allotetraploid X. laevis (2n = 36)...
  59. ncbi [Importance of development of ecotoxicogenomics in understanding molecular mechanisms of chemicals in developing animals]
    Taisen Iguchi
    National Institutes of Natural Sciences, National Institute for Basic Biology, Okazaki Institute for Integrative Bioscience, Myodaiji, Japan
    Nihon Eiseigaku Zasshi 61:11-8. 2006
    ..were cloned in various species, including the American alligator, crocodile, Florida red-bellied turtle, Silurana tropicalis, roach, Fundulus and mosquito fish...
  60. doi Downstream of FGF during mesoderm formation in Xenopus: the roles of Elk-1 and Egr-1
    Oliver Nentwich
    Wellcome Trust Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Dev Biol 336:313-26. 2009
    ..Superficially, Xenopus tropicalis embryos with reduced levels of XEgr-1 resemble those lacking XElk-1, but to our surprise, levels of Xbra are ..
  61. pmc The Western Clawed Frog (Xenopus tropicalis): An Emerging Vertebrate Model for Developmental Genetics and Environmental Toxicology
    Chris Showell
    UNC McAllister Heart Institute, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    CSH Protoc 2009:pdb.emo131. 2009
    INTRODUCTION Xenopus tropicalis, also known as Silurana tropicalis or the Western clawed frog, is a small, wholly aquatic frog that is found in the countries that lie along the west coast of equatorial Africa from Gabon to Sierra Leone...
  62. ncbi Ontogeny of the bizarre: an osteological description of Pipa pipa (Anura: pipidae), with an account of skeletal development in the species
    L Trueb
    Natural History Museum and Biodiversity Research Center Dyche Hall, and Department of Ecology and Evolutionary Biology, The University of Kansas, Lawrence, KS 66045 2454, USA
    J Morphol 243:75-104. 2000
    ..In addition, ontogenetic comparisons reveal that the sacrum forms differently in Discoglossus sardus,Silurana tropicalis, and P.pipa. The development of the sphenethmoid region of the skull is the same in P.pipa and X...
  63. doi Orthologs of magainin, PGLa, procaerulein-derived, and proxenopsin-derived peptides from skin secretions of the octoploid frog Xenopus amieti (Pipidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 31:989-94. 2010
    ..amieti lineage. However, the very low antimicrobial activity of the magainin-AM1 and PGLa-AM2 paralogs suggests the possibility that certain peptides may have evolved toward a new, as yet undetermined, function (neofunctionalization)...
  64. ncbi Evolutionary history of the somatostatin and somatostatin receptors
    Muhammad Moaeen-ud-Din
    China Education Ministry s Key Laboratory of Animal Breeding, Genetics and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    J Genet 88:41-53. 2009
    ..We used comparative whole genome analysis of Danio rerio, Carassius auratus, Xenopus tropicalis, Gallus gallus, Monodelphis domestica, Homo sapiens, Sus scrofa, Bos taurus, Mus musculus, Rattus norvegicus,..
  65. pmc Gel-forming mucins appeared early in metazoan evolution
    Tiange Lang
    Department of Medical Biochemistry, Institute of Biomedicine, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Proc Natl Acad Sci U S A 104:16209-14. 2007
    ..The frog Xenopus tropicalis stands out because the number of gel-forming mucins has markedly increased to at least 25 as compared with 5 ..
  66. pmc Cryptochrome genes are highly expressed in the ovary of the African clawed frog, Xenopus tropicalis
    Yoko Kubo
    Department of Electrical Engineering and Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
    PLoS ONE 5:e9273. 2010
    ..In this study, we identified two CRYs, XtCRY1 and XtCRY2 in Xenopus tropicalis, an excellent experimental model species...
  67. pmc Aging of Xenopus tropicalis eggs leads to deadenylation of a specific set of maternal mRNAs and loss of developmental potential
    Anna Kosubek
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, Essen, Germany
    PLoS ONE 5:e13532. 2010
    ..Since the molecular events in aging eggs may be similar in these species, we established in the frog Xenopus tropicalis a defined protocol for delayed fertilization of eggs...
  68. ncbi Evolution of Hoxa-11 in lineages phylogenetically positioned along the fin-limb transition
    C H Chiu
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520 8106, USA
    Mol Phylogenet Evol 17:305-16. 2000
    ..5 billion years of evolutionary time. Here, Hoxa-11 gene proper sequences were determined for frog (Xenopus tropicalis), coelacanth (Latimeria chalumnae), common zebrafish (Danio rerio; Hoxa-11a and Hoxa-11b paralogs), and ..
  69. ncbi Divergence of conserved non-coding sequences: rate estimates and relative rate tests
    Gunter P Wagner
    Department of Ecology and Evolutionary Biology Yale University, New Haven, Connecticut, USA
    Mol Biol Evol 21:2116-21. 2004
    ..species: a shark, Heterodontus francisci; a basal ray finned fish, Polypterus senegalus; the amphibian, Xenopus tropicalis; as well as three mammalian species, human, rat and mouse...
  70. doi Reproductive toxicity in Xenopus tropicalis after developmental exposure to environmental concentrations of ethynylestradiol
    Irina Gyllenhammar
    Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala CRU, Norbyvagen 18A, 75236 Uppsala, Sweden
    Aquat Toxicol 91:171-8. 2009
    ..b>Xenopus tropicalis tadpoles were exposed until metamorphosis to 6, 60, and 600 pM EE(2)...
  71. pmc Remobilization of Tol2 transposons in Xenopus tropicalis
    Donald A Yergeau
    Department of Pathology, St, Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    BMC Dev Biol 10:11. 2010
    ..integrates its corresponding non-autonomous transposable element into the genome of the diploid frog, Xenopus tropicalis. Tol2 transposons are stable in the frog genome and are transmitted to the offspring at the expected ..
  72. doi Teratogenic effects of tetrabromobisphenol A on Xenopus tropicalis embryos
    Huahong Shi
    Department of Environmental Science, Key Laboratory of Urbanization and Ecological Restoration, East China Normal University, Shanghai 200062, China
    Comp Biochem Physiol C Toxicol Pharmacol 152:62-8. 2010
    ..We reported exposing Xenopus tropicalis embryos (NF10) to 0.01, 0.1 or 1 mg/L of TBBPA with or without 70 microg/L triiodothyronine (T(3))...
  73. pmc Control of kidney, eye and limb expression of Bmp7 by an enhancer element highly conserved between species
    Derek Adams
    Maine Medical Center Research Institute, 81 Research Drive, Scarborough, Maine 04074, USA
    Dev Biol 311:679-90. 2007
    ..conserved both in sequence and position in the Bmp7 locus between different vertebrates, ranging from Xenopus tropicalis to Homo sapiens, demonstrating that there is strong selective pressure for Bmp7 expression at these tissue ..
  74. pmc Identification of novel transcripts with differential dorso-ventral expression in Xenopus gastrula using serial analysis of gene expression
    Fernando Faunes
    Center for Cell Regulation and Pathology and Center for Aging and Regeneration, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, 8331150, Chile
    Genome Biol 10:R15. 2009
    ..In order to identify novel transcripts involved in dorso-ventral patterning, we compared dorsal and ventral transcriptomes of Xenopus tropicalis at the gastrula stage using serial analysis of gene expression (SAGE).
  75. doi A systematic search and classification of T2 family miniature inverted-repeat transposable elements (MITEs) in Xenopus tropicalis suggests the existence of recently active MITE subfamilies
    Akira Hikosaka
    Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Hiroshima 739 8521, Japan
    Mol Genet Genomics 283:49-62. 2010
    ..A terminal sequence motif (T2-motif: TTAAAGGRR) was retrieved from the Xenopus tropicalis genome database. We then selected 51- to 1,000-bp MITE candidates framed by an inverted pair of 2 T2-motifs...
  76. ncbi Goosecoid promotes head organizer activity by direct repression of Xwnt8 in Spemann's organizer
    J Yao
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Development 128:2975-87. 2001
    ..Therefore, Gsc promotes head organizer activity by direct repression of Xwnt8 in Spemann's organizer and this activity is essential for anterior development...
  77. pmc An amphibian with ambition: a new role for Xenopus in the 21st century
    C W Beck
    Developmental Biology Programme, School of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Genome Biol 2:REVIEWS1029. 2001
    ..Possibilities are also emerging for genomic studies using the closely related diploid frog Xenopus tropicalis.
  78. ncbi Secondary neurogenesis in the brain of the African clawed frog, Xenopus laevis, as revealed by PCNA, Delta-1, Neurogenin-related-1, and NeuroD expression
    Mario F Wullimann
    Centre National de la Recherche Scientifique Institute of Neurobiology A Fessard, F 91198 Gif sur Yvette, France
    J Comp Neurol 489:387-402. 2005
    ..Altogether, the data presented suggest a common brain bauplan on the level of early proliferation patterns and neurogenic/proneural gene activity in anamniotes, if not vertebrates...
  79. ncbi Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
    Gary Davidson
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 438:867-72. 2005
    ..Our results reveal an evolutionarily conserved mechanism that couples Wnt receptor activation to the cytoplasmic signal transduction apparatus...
  80. ncbi Ras-dva, a member of novel family of small GTPases, is required for the anterior ectoderm patterning in the Xenopus laevis embryo
    Maria B Tereshina
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, Moscow, Russia
    Development 133:485-94. 2006
    ..Together, the data obtained indicate that Ras-dva is an essential component of the signaling network that patterns the early anterior neural plate and the adjacent ectoderm in the Xenopus laevis embryos...
  81. pmc The evolutionary conservation of the core components necessary for the extrinsic apoptotic signaling pathway, in Medaka fish
    Kazuhiro Sakamaki
    Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    BMC Genomics 8:141. 2007
    ..While the apoptotic machinery governing the extrinsic signaling pathway is well characterized in mammals, it is not fully understood in fish...
  82. pmc Ligand specificity and evolution of liver X receptors
    Erica J Reschly
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, United States
    J Steroid Biochem Mol Biol 110:83-94. 2008
    ..The present study reports the cloning of LXRs from African clawed frog (Xenopus laevis), Western clawed frog (Xenopus tropicalis), and zebrafish (Danio rerio), and their functional characterization and comparison ..
  83. doi TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates
    Yasuko Onuma
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Zoolog Sci 25:706-13. 2008
    ..TRIQK proteins are localized to the endoplasmic reticulum membrane. Depletion of endogenous xTRIQK protein in Xenopus embryos causes no detectable morphological or functional changes in tadpoles...
  84. doi Expression of Xenopus tropicalis HNF6/Onecut-1
    Kim E Haworth
    Cardiff School of Biosciences, Cardiff University, Biomedical Sciences Museum Avenue, Cardiff, Wales, UK
    Int J Dev Biol 53:159-62. 2009
    ..In the present study, we analyzed the pattern of expression of Onecut-1/HNF6 in Xenopus tropicalis using RT-PCR and whole mount in situ hybridization...
  85. doi Xenopus tropicalis as a test system for developmental and reproductive toxicity
    Cecilia Berg
    Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala CRU, Norbyvägen 18 A, Uppsala, Sweden
    J Toxicol Environ Health A 72:219-25. 2009
    The usefulness of Xenopus tropicalis as a model species to investigate endocrine disruption and developmental reproductive toxicity was assessed...
  86. doi Functional dissection of XDppa2/4 structural domains in Xenopus development
    Doreen Siegel
    Institute of Biochemistry, University of Ulm, Albert Einstein Allee 11, D 89081 Ulm, Germany
    Mech Dev 126:974-89. 2009
    ..The SAP domain is required for association of XDppa2/4 to chromatin and for embryonic survival at later stages of development suggesting epigenetic programming events...
  87. doi Identification of an abundant allergen from the sheep louse, Bovicola ovis
    A Pfeffer
    Hopkirk Research Institute, AgResearch Ltd, Private Bag 11008, Palmerston North 4442, New Zealand
    Int J Parasitol 40:911-9. 2010
    ..proteins of unknown function from diverse species and weak homology with lipid-binding proteins of Xenopus tropicalis and Galleria mellonella...
  88. doi Effects of tributyltin (TBT) on Xenopus tropicalis embryos at environmentally relevant concentrations
    Suzhen Guo
    Department of Environmental Science, East China Normal University, Shanghai 200062, China
    Chemosphere 79:529-33. 2010
    ..In this paper, we exposed embryos of Xenopus tropicalis to 50-400ngL(-1) tributyltin chloride...
  89. pmc Phylogenetic and developmental study of CD4, CD8 α and β T cell co-receptor homologs in two amphibian species, Xenopus tropicalis and Xenopus laevis
    Asiya Seema Chida
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Dev Comp Immunol 35:366-77. 2011
    ..Using experimental and computational procedures we identified CD4, CD8α and CD8β gene homologs both in Xenopus tropicalis, whose full genome has been sequenced, and its sister species Xenopus laevis...
  90. pmc Expansion of voltage-dependent Na+ channel gene family in early tetrapods coincided with the emergence of terrestriality and increased brain complexity
    Harold H Zakon
    Section of Neurobiology, The University of Texas, USA
    Mol Biol Evol 28:1415-24. 2011
    ..The duplication of Nav channel genes allowed for greater regional specialization in Nav channel expression, variation in subcellular localization, and enhanced processing of somatosensory input...
  91. pmc Characterization of a novel Xenopus tropicalis cell line as a model for in vitro studies
    Ludivine Sinzelle
    Institute of Systems and Synthetic Biology, Genopole, CNRS, Universite d Evry Val d Essonne, Genavenir 3 Genopole campus 3, 1 rue Pierre Fontaine, Evry, France
    Genesis 50:316-24. 2012
    ..We describe a new permanent fibroblast-type cell line obtained from disaggregated Xenopus tropicalis limb bud. The cell line population doubling time was ~24 h...
  92. doi A proteomic approach to investigate the distribution and abundance of surface and internal Fasciola hepatica proteins during the chronic stage of natural liver fluke infection in cattle
    Orcun Hacariz
    TUBITAK Marmara Research Center, Genetic Engineering and Biotechnology Institute, P O Box 21, 41470, Gebze, Kocaeli, Turkey
    J Proteome Res 11:3592-604. 2012
    ..Potentially novel F. hepatica proteins showing homology with AKT interacting protein (Xenopus tropicalis), sterol O-acyltransferase 2 (Homo sapiens), and integrin beta 7 (Mus musculus) were identified with high ..
  93. doi Developmental regulation of locomotive activity in Xenopus primordial germ cells
    Kohei Terayama
    Department of Life Science, Graduate School of Life Science, University of Hyogo, 3 2 1 Koto, Kamigori, Akou gun, 678 1297, Japan
    Dev Growth Differ 55:217-28. 2013
    ..We also showed that the locomotion and blebbing of the PGCs required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling...
  94. doi Characterization of an outward rectifying chloride current of Xenopus tropicalis oocytes
    Lenin David Ochoa-de la Paz
    Departamento de Neurobiologia Celular y Molecular, Instituto de Neurobiologia, Campus UNAM Juriquilla, Mexico
    Biochim Biophys Acta 1828:1743-53. 2013
    Here, we describe an outward rectifying current in Xenopus tropicalis oocytes that we have called xtClC-or...
  95. pmc Xenbase, the Xenopus model organism database; new virtualized system, data types and genomes
    J Brad Karpinka
    University of Calgary Computer Science, Calgary, Alberta, Canada
    Nucleic Acids Res 43:D756-63. 2015
    ..Xenopus laevis that is widely used for microinjection and tissue explant-based protocols, and the diploid Xenopus tropicalis which is used for genetics and gene targeting...
  96. pmc Unliganded thyroid hormone receptor α controls developmental timing in Xenopus tropicalis
    Luan Wen
    Section on Molecular Morphogenesis, Program on Cell Regulation and Metabolism, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    Endocrinology 156:721-34. 2015
    ..We have designed transcriptional activator-like effector nucleases (TALENs) to mutate the TRα gene in Xenopus tropicalis. We show that knockdown of TRα enhances tadpole growth in premetamorphic tadpoles, in part because of ..
  97. pmc Understanding early organogenesis using a simplified in situ hybridization protocol in Xenopus
    Steven J Deimling
    Developmental and Stem Cell Biology, Hospital for Sick Children
    J Vis Exp . 2015
    ..Although the protocol describes assessing organogenesis in Xenopus laevis, the same basic protocol can almost certainly be adapted to Xenopus tropicalis and other model systems.
  98. doi Sex chromosome conservation, DMRT1 phylogeny and gonad morphology in diploid Palearctic green toads (Bufo viridis subgroup)
    Stephanie Tamschick
    Leibniz Institute of Freshwater Ecology and Inland Fisheries IGB, Berlin, Germany
    Cytogenet Genome Res 144:315-24. 2014
    ..Markers corroborate the largest chromosome pair 1 (homologous to linkage group 1 of Xenopus tropicalis) to represent the sex chromosomes in diploid species of the B. viridis subgroup (B. siculus, B...
  99. doi Arsenic(+3) and DNA methyltransferases, and arsenic speciation in tadpole and frog life stages of western clawed frogs (Silurana tropicalis) exposed to arsenate
    Iris Koch
    Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Canada
    Metallomics 7:1274-84. 2015
    b>Western clawed frog (Silurana tropicalis) embryos were exposed to control, low (nominally 0...
  100. pmc Molecular asymmetry in the 8-cell stage Xenopus tropicalis embryo described by single blastomere transcript sequencing
    Elena De Domenico
    The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Dev Biol 408:252-68. 2015
    ..Here we report an unbiased analysis of the distribution of maternal mRNA on all axes of the Xenopus tropicalis 8-cell stage embryo, based on sequencing of single blastomeres whose positions within the embryo are known...
  101. doi Hematologic reference intervals for Xenopus tropicalis with partial use of automatic counting methods and reliability of long-term stored samples
    Lily A Maxham
    Department of Biology, University of Prince Edward Island, Charlottetown, PE, Canada
    Vet Clin Pathol 45:291-9. 2016
    The African frog, Xenopus tropicalis, is widely used in biomedical and toxicologic research. Reference intervals (RI) for hematologic variables, valuable to research and health status assessment, have not been established.

Research Grants62

  1. Insertional mutagenesis screen for otic genes in Xenopus
    Sigrid Reinsch; Fiscal Year: 2003
    ..aims: (1) We will use insertional mutagenesis to generate stable GFP- expressing lines of the true diploid, Xenopus tropicalis, carrying transgenes expressed in the otic regions...
  2. Genetic Analysis of Silurana Tropicalis Development
    Richard Harland; Fiscal Year: 2005
    ..Our main goal in this proposal is to establish methods that will test the utility of Silurana tropicalis as an additional useful organism for genetic manipulation...
  3. Richard M Harland; Fiscal Year: 2015
    ..In order to understand normal inner ear development, we will use the genetically tractable frog, Xenopus tropicalis, to investigate the genetic network underlying ear development...
  4. A genome assembly for Xenopus laevis
    DANIEL SOLEYMAN ROKHSAR; Fiscal Year: 2013
    ..a comprehensive understanding of life's processes, we propose here to complement the genome assembly of Xenopus tropicalis with a gene and protein level genome assembly for Xenopus laevis...
  5. DANIEL SOLEYMAN ROKHSAR; Fiscal Year: 2016
    ..here to continue improvement of both the short range, and long range (chromosome level) assemblies of Xenopus tropicalis and Xenopus laevis...
  6. Genomic survey of cis-regulatory element function by high-throughput transgenesis
    Robert M Grainger; Fiscal Year: 2012
    Our aim is to develop Xenopus tropicalis as a robust, relevant and rapid vertebrate model system for the analysis of the regulatory functions conferred by gene-specific conserved non-coding elements (CNEs)...
  7. Alan M Lambowitz; Fiscal Year: 2016
    ..4) To use Xenopus tropicalis to further develop methods for using group II introns for gene targeting in eukaryotes via sperm DNA ..
  8. Rebecca W Heald; Fiscal Year: 2015
    ..First, we can compare Xenopus laevis to the smaller, related species Xenopus tropicalis, which lays smaller eggs and has proportionally smaller cells throughout development...
  9. Gert Jan C Veenstra; Fiscal Year: 2015
    ..Embryos of the amphibian Xenopus tropicalis represent an excellent model system for development and differentiation...
  10. CSHL Cell and Developmental Biology of Xenopus
    TERRI I GRODZICKER; Fiscal Year: 2013
    ..extensive laboratory exposure to the biology and manipulation of embryos from the frogs Xenopus laevis and Xenopus tropicalis. This course prepares students for independent research in the cell, genetic, and molecular analysis of ..
  11. Julie C Baker; Fiscal Year: 2015
    ..In this grant, we use Xenopus laevis and Xenopus tropicalis to address the involvement of the chromatin state and its interface with the Nodal signaling factor, smad2/3,..
  12. Deciphering Principles of Regulatory Genomics
    Gabriela G Loots; Fiscal Year: 2010
    ..bioinformatics and comparative genomics with molecular biology expertise in a new model organism, the frog Xenopus tropicalis, to determine the genomic encryption of tissue-specific gene regulation, with emphasis on skeletal muscle ..
  13. Group II Intron-Based Gene Targeting Methods for Xenopus
    Alan Lambowitz; Fiscal Year: 2009
    ..We propose to develop efficient group II intron-based gene targeting methods for Xenopus laevis and Xenopus tropicalis. Mobile group II introns insert site-specifically into DNA target sites by a remarkable mechanism in which ..
  14. Characterization of neural crest gene expression using a new transgenic Xenopus m
    Shuo Wei; Fiscal Year: 2013
    ..Toward this objective a transgenic Xenopus tropicalis line that expresses fluorescent reporter in the neural crest lineage (the snail2-egfp line) has been ..
  15. Developing transposon methods for insertional mutagenesis in Xenopus
    Mustafa K Khokha; Fiscal Year: 2010
    ..The main goal of this proposal is to develop transposon tools in order to mutagenize the genome of Xenopus tropicalis. Recently, we have developed genetic analysis in Xenopus which is an exciting new avenue for studying gene ..
  16. Transcriptional regulation of liver specification in Xenopus tropicalis
    ANDREA ELIZABETH WILLS; Fiscal Year: 2012
    ..Therefore, the proposed research will be carried out in the frog Xenopus tropicalis, which has large numbers of readily manipulated embryos ideal for rapid screening and biochemical ..
  17. Characterization and cloning of X. tropicalis Craniofacial Mutants
    Mustafa K Khokha; Fiscal Year: 2012
    ..In this proposal, we will investigate craniofacial development in an emerging model system, Xenopus tropicalis. During a recent forward genetic screen, we identified two mutants, jaws and jawbreaker, that exhibit a ..
  18. Genetic Analysis of Inner Ear Development in tropicalis
    Richard M Harland; Fiscal Year: 2010
    ..underlying molecular and genetic interactions, we are undertaking a forward genetic screen in the amphibian Xenopus tropicalis, a recently introduced genetic model animal...
  19. Craniofacial and cardiac development in Xenopus: A genetic approach
    Mustafa K Khokha; Fiscal Year: 2013
    ..To this end, we will use the model organism Xenopus tropicalis to conduct forward and reverse genetics screens to generate animal for human disease states and to identify ..
  20. Homologous recombination in Xenopus and Zebrafish
    Sigrid Reinsch; Fiscal Year: 2005
    ..2) The investigators will target a chromosomal Green Fluorescent Protein (GFP) transgene in Xenopus tropicalis embryos to generate visually screenable loss of function phenotypes...
  21. Genetic map of the Xenopus tropicalis genome
    Dan Wells; Fiscal Year: 2006
    The proposed work will generate key resources for genetic and molecular studies of the amphibian Xenopus tropicalis. Xenopus tropicalis is an emerging model system for the genetic analysis of vertebrate development, combining the many ..
  22. Genetic Screens in Xenopus tropicalis
    DEREK STEMPLE; Fiscal Year: 2004
    Two pilot genetic screens using the diploid amphibian Xenopus tropicalis are proposed...
  23. Toxicant Target Genes in Xenopus and Zebrafish Embryos
    Jeremy Green; Fiscal Year: 2004
    ..g., neural tube closure). A third species, Xenopus tropicalis (X. tropicalis) is a cousin of X. laevis, is suitable for genetics but is novel as an experimental species...
  24. Development of the Acoustico-Vestibular System
    ELBA SERRANO; Fiscal Year: 2005
    ..Results of these investigations also may be valuable in design of treatments for hereditary and environmentally-induced sensory disorders of hearing and balance. ..
  25. Development of the Vertebrate Primary Mouth
    Hazel Sive; Fiscal Year: 2007
    ..are to define the molecular mechanisms involved in vertebrate primary mouth formation, using the frog Xenopus tropicalis as a model...
  26. VEGETALLY LOCALIZED TRANSCRIPTS
    LAURENCE ETKIN; Fiscal Year: 2000
    ..has cloned a family of genes that code for interspersed repeat transcripts from Xenopus laevis (xlsirts) and Xenopus tropicalis (xtsirts)...
  27. New vertebrate model organism cDNA libraries
    Bruce Blumberg; Fiscal Year: 2003
    ..available a set of normalized, full-length cDNA libraries from the emerging vertebrate model organism Xenopus tropicalis. These libraries will be constructed identically and in the same expression vector capable of directing ..
  28. CELL AND DEVELOPMENTAL BIOLOGY OF XENOPUS
    TERRI GRODZICKER; Fiscal Year: 2003
    ..assays; 7) Oligonucleotide antisense techniques for "Knock- out" of maternal molecules; 8) Preparation and use of cell cycle extracts for construction of transgenic embryos; and 9) Use of Xenopus tropicalis as a genetic model.
  29. NEW STRATEGIES FOR UNDERSTANDING FOREBRAIN DEVELOPMENT
    Robert Grainger; Fiscal Year: 2002
    ..amphibian studies in the genetically tractable animal (it's diploid and has a short generation time) Xenopus tropicalis. The objective of the current research proposal is technological (to construct transgenic animals in which ..
  30. ROLE OF NON-CLASSICAL MHC CLASS I AND HSPs IN IMMUNITY
    Jacques Robert; Fiscal Year: 2009
    ..Do hsp70 and gp96 generate similar anti-tumor CCU-CTL effectors? Aim 3. How important is the hsp-generated CCU-CTL responses in tumor immunity in vivo? Aim 4. Do CCU-CTLs interact with class Ib molecules? ..
  31. Genetic Control of Early Retinal Development
    Robert M Grainger; Fiscal Year: 2010
    ..Third, we will examine the regulation of and interactions among a critical group of transcription factors essential for retina formation in order to ascertain their roles in the determination mechanism. ..
  32. AMPHIBIAN MODEL FOR VERTEBRATE DEVELOPMENTAL GENETICS
    Robert Grainger; Fiscal Year: 2008
    ..tropicalis. This project should complement the growing genomic resources for X. tropicalis which include a genome project to commence in the summer of 2002. ..
  33. GENETIC CONTROL OF LENS FORMATION
    Robert Grainger; Fiscal Year: 2001
    ..The final goal is to test the function of transcriptional regulatory genes in controlling lens competence, bias and specification in Xenopus embryos. ..
  34. INDUCTION OF THE EMBRYONIC LENS
    Robert Grainger; Fiscal Year: 2005
    ..This proposal also utilizes new technology we have developed for the amphibian Xenopus tropicalis which has a diploid genome and short life cycle that make it far more suitable than Xenopus laevis for ..
  35. Proteomics of Egg Cortical Granules
    LEANN LINDSAY; Fiscal Year: 2003
    ..This approach will identify potential molecules important in egg extracellular matrix modifications, which will be the subject of future investigations. ..
  36. Insertional Mutagenesis Strategies in Xenopus tropicalis
    Paul Mead; Fiscal Year: 2006
    ..The proposed study will provide valuable insight into the biology of hematopoiesis in both normal and disease states. ..
  37. Functions of Mammalian thioredoxin reductases
    VADIM GLADYSHEV; Fiscal Year: 2009
    ..iii) What are the determinants for preferential supply of thioredoxin reductases with selenium? We will examine elements in thioredoxin reductase genes responsible for this effect. ..
  38. Xenbase: a Xenopus Model Organism Database
    PETER VIZE; Fiscal Year: 2009
    ..abstract_text> ..
  39. Antisense Mediated Suppression of Dystrophin Mutations
    Michael Howard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  40. Selenoprotein Synthesis: Redefinition of Selenocysteine-encoding UGA Codons
    Michael T Howard; Fiscal Year: 2010
    ....
  41. Tol2-mediated gene and enhancer trapping in Xenopus tropicalis
    Paul E Mead; Fiscal Year: 2010
    ..We are currently characterizing the novel integration events in the progeny from the other remobilized F2 frogs. We anticipate submitting a manuscript describing this data soon. ..
  42. Analysis of Noelin, a Neural Crest Competence Factor
    Marianne Bronner Fraser; Fiscal Year: 2005
    ..3) Generate and characterize the phenotype of Noelin-1 null mutant. (4) Examine the environmental regulation of Noelin-1 expression. ..
  43. INDUCTION OF THE NEURAL CREST
    Marianne Bronner Fraser; Fiscal Year: 2008
    ..3. Examine the possible role of Notch signaling in cell fate decisions within the neural folds as cells choose between neural crest, neural tube or epidermal fates. ..
  44. ROLE OF ID2 IN CRANIOFACIAL DEVELOPMENT
    Marianne Bronner Fraser; Fiscal Year: 2004
    ..2. examine the function of E12 in neural crest development and craniofacial patterning. 3. identify and characterize an achaete-scute homolog(s) that potentially interacts with Id2/E proteins. ..
  45. Molecular analysis of neural crest migration
    Marianne Bronner Fraser; Fiscal Year: 2007
    ..2. The function of the a5 subunit of laminin in early neural crest development. 3. The function of a novel chemokine in neural crest migration. 4. The function of this novel chemokine in limb development. ..
  46. ECTODERMAL PLACODE DEVELOPMENT INTO CRANIAL GANGLIA
    Marianne Bronner Fraser; Fiscal Year: 2003
    ..2) examine the induction and development of the nodose placode. 3) identify molecular markers for other epibranchial placodes. 4) examine the interrelationships of the neural crest and placodes. ..
  47. Meeting: Development of the Spinal Cord and Neural Crest
    Marianne Bronner Fraser; Fiscal Year: 2002
    ....
  48. INDUCTION OF THE NEURAL CREST
    Marianne Bronner Fraser; Fiscal Year: 2001
    ..3. Determine the competence of ectoderm and neural plate to assume a neural crest fate. 4. Determine the competence of neural crest cells to assume a neural tube fate after transplantation into the ventral neural tube. ..
  49. SENSORY RECALIBRATION OF MOTOR OUTPUT
    Harold Zakon; Fiscal Year: 2004
    ..abstract_text> ..
  50. Cochlear Type II Afferents and Nociception in the Inner*
    Jaime Garcia Anoveros; Fiscal Year: 2004
    ....
  51. Gordon Research Conference on Neuroethology
    Harold Zakon; Fiscal Year: 2002
    ..Our goal is for broad intellectual and technical cross-fertilization between these two traditions. ..
  52. A Genetic Approach to Organogenesis in Xenopus
    Frank Conlon; Fiscal Year: 2006
    ..to determine the precise endogenous role for SHP-2 and TBX5 in early organ development in the diploid frog Xenopus tropicalis (X. tropicalis)...
  53. Mechanism of cytochrome P450 uncoupling and inactivation
    JARED GOLDSTONE; Fiscal Year: 2005
    ..Recently identified AhR-agonistic persistent pollutants, such as polybrominated diphenyl ethers will also be investigated. ..
  54. Genetic methods using the Tol2 transposable element
    Koichi Kawakami; Fiscal Year: 2006
    ..abstract_text> ..
  55. Requirements for the FGF/MAPK in early heart development
    Frank Conlon; Fiscal Year: 2007
    ..abstract_text> ..
  56. Antibacterial peptidoglycan recognition proteins
    Roman Dziarski; Fiscal Year: 2007
    ..abstract_text> ..
  57. MOLECULAR AND CELLULAR BASIS OF LENS DEVELOPMENT
    Jonathan J Henry; Fiscal Year: 2010
    ....
  58. HORMONAL MODULATION OF A COMMUNICATION SIGNAL
    Harold Zakon; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    Anthony B Firulli; Fiscal Year: 2010
    ..The understanding gained from this proposal will add significant insight into the molecular mechanisms that drive heart formation and go awry in human disease. ..
  60. THYROID HORMONE CONTROL OF A GENE EXPRESSION NETWORK
    J Furlow; Fiscal Year: 2008
    ..abstract_text> ..
  61. Specificity and Spatial Dynamics of Cell Signaling: The*
    Qing Nie; Fiscal Year: 2008
    ..New mathematical theories and numerical algorithms will have to be developed for the analysis and simulations. ..
  62. Role of fetal TCDD-activited AHR in adult heart disease
    Craig Tomlinson; Fiscal Year: 2008
    ..unreadable] [unreadable]..

Patents62

  1. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
    Patent Number: JP2016507218-A; Date:2016-03-10
  2. O-CADHERIN AS A BIOMARKER FOR CIRCULATING TUMOR CELLS
    Patent Number: EP3029460-A1; Date:2016-06-08
  3. COMPOSITIONS AND METHODS MODULATING MG29 FOR THE TREATMENT OF DIABETES
    Patent Number: KR1020140054369-A; Date:2014-05-08
  4. C1Q/TNF-RELATED PROTEIN 12 AND COMPOSITIONS AND METHODS OF USING SAME
    Patent Number: EP2696886-A2; Date:2014-02-19
  5. FUNCTIONAL EXPRESSION OF BACTERIAL MAJOR FACILITATOR SUPERFAMILY (SFM) GENE IN MAIZE TO IMPROVE AGRONOMIC TRAITS AND GRAIN YIELD
    Patent Number: WO2014164116-A1; Date:2014-10-09
  6. Polypeptide Vaccine
    Patent Number: JP2014526462-A; Date:2014-10-06
  7. TIKI INHIBITORS
    Patent Number: EP2836514-A1; Date:2015-02-18
  8. DETECTION METHODS
    Patent Number: WO2015097030-A1; Date:2015-07-02
  9. DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES
    Patent Number: JP2014131515-A; Date:2014-07-17
  10. MICRO-RNAS THAT CONTROL MYOSIN EXPRESSION AND MYOFIBER IDENTITY
    Patent Number: JP2015013864-A; Date:2015-01-22
  11. transcriptional regulatory oligonucleotide
    Patent Number: JP2014233223-A; Date:2014-12-15
  12. Method for couplig keratin-binding polypeptides with effector molecules which support carboxylic groups or sulfonic acid groups
    Patent Number: JP2009521404-A; Date:2009-06-04
  13. Nucleic acid for controlling fibrillization of cells or tissues
    Patent Number: WO2011019074-A; Date:2011-02-17
  14. MICRO-RNAS THAT CONTROL MYOSIN EXPRESSION AND MYOFIBER IDENTITY
    Patent Number: JP2010535246-A; Date:2010-11-18
  15. Isolation of the t-complex distorters and applications thereof
    Patent Number: WO2007020026-A1; Date:2007-02-22
  16. Chimeric keratin-binding effector proteins
    Patent Number: WO2007060117-A2; Date:2007-05-31
  17. Keratin-binding effector molecules containing reactive dyes
    Patent Number: WO2007063024-A2; Date:2007-06-07
  18. Novel human, feline, chicken and other animal interferons and uses thereof
    Patent Number: WO2006099451-A2; Date:2006-09-21
  19. miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
    Patent Number: JP2010504349-A; Date:2010-02-12
  20. miR-200 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
    Patent Number: JP2010504350-A; Date:2010-02-12
  21. Nucleic acid controling mast cell degranulation
    Patent Number: WO2009148137-A; Date:2009-12-10
  22. KERATIN-BINDING EFFECTOR MOLECULES CONTAINING REACTIVE DYES
    Patent Number: JP2009523706-A; Date:2009-06-25
  23. KERATIN-BINDING EFFECTOR MOLECULES, AND METHOD FOR THE PRODUCTION THEREOF
    Patent Number: JP2009517361-A; Date:2009-04-30
  24. Process for the production of a fine chemical
    Patent Number: WO2008034648-A1; Date:2008-03-27
  25. Method for the production of a keratin-binding effector molecule
    Patent Number: WO2007147445-A; Date:2007-12-27
  26. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  27. DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES
    Patent Number: JP2006517412-A; Date:2006-07-27
  28. COMPOSITIONS AND METHODS MODULATING MG29 FOR THE TREATMENT OF DIABETES
    Patent Number: KR1020120061070-A; Date:2012-06-12
  29. Micro-RNA and tissue repair
    Patent Number: EP2327781-A1; Date:2011-06-01
  30. A Method for separating and purifying low molecular weight RNA
    Patent Number: JP2007202521-A; Date:2007-08-16
  31. A novel gene: BENI [Branchyury Expression by Nuclear Inhibitor] dominating mesoderm formation during early vertebrate development
    Patent Number: JP2007312716-A; Date:2007-12-06
  32. COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE
    Patent Number: WO2009044895-A; Date:2009-04-09
  33. A nucleics Acid regulating cell growth
    Patent Number: WO2009044899-A; Date:2009-04-09
  34. Methods for Treating and Identifying Compounds to Treat Age-Related Macular Degeneration Treatment
    Patent Number: JP2011520788-A; Date:2011-07-21
  35. Lysosomal associated membrane protein (lamp) - like polypeptide, ligands to the same, and use of the same in the frame of detection and purification of human plasmacytoid dendritic cells
    Patent Number: WO2008075174-A2; Date:2008-06-26
  36. Biomarkers for human papillomavirous-associated cancers
    Patent Number: WO2009015294-A1; Date:2009-01-29
  37. Mir-124 regulated genes and pathways as targets for therapeutic intervention
    Patent Number: WO2009070805-A1; Date:2009-06-04
  38. Mir-10 regulated genes and pathways as targets for therapeutic intervention
    Patent Number: WO2009086156-A2; Date:2009-07-09
  39. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  40. Methods and compositions for the regulation of microrna processing
    Patent Number: WO2009126563-A1; Date:2009-10-15
  41. Methods and compositions for treating and identifying compounds to treat age-related macular degeneration
    Patent Number: WO2009129497-A2; Date:2009-10-22
  42. Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
    Patent Number: WO2008036776-A2; Date:2008-03-27
  43. Means and methods for counteracting, preventing and/or determining fibrosis or a risk of fibrosis
    Patent Number: WO2010036111-A1; Date:2010-04-01
  44. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  45. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  46. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  47. Rationale, methods, and assays for identifying human and non-human primate taste specific genes and use thereof in taste modulator and therapeutic screening assays
    Patent Number: EP2164976-A2; Date:2010-03-24
  48. Identification of trpml3 (mcoln3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone and/or vasopressin production or release
    Patent Number: EP2167643-A2; Date:2010-03-31
  49. COMPOSITIONS AND METHODS MODULATING MG29 FOR THE TREATMENT OF DIABETES
    Patent Number: EP2437771-A2; Date:2012-04-11
  50. Nucleic acid for controlling cell cycle
    Patent Number: WO2011111715-A; Date:2011-09-15
  51. DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES
    Patent Number: JP2012090630-A; Date:2012-05-17
  52. DUAL TARGETING OF MIR-208 AND MIR-499 IN THE TREATMENT OF CARDIAC DISORDERS
    Patent Number: JP2012516856-A; Date:2012-07-26
  53. Regulatory region for Xenopus Lef-1 expression and its use
    Patent Number: EP1498423-A1; Date:2005-01-19
  54. Regulatory region for xenopus lef-1 expression and its use
    Patent Number: WO2005010041-A2; Date:2005-02-03
  55. METHODS FOR IDENTIFYING COMPOUNDS THAT MODULATE WNT SIGNALING IN CANCER CELLS
    Patent Number: EP2283160-A1; Date:2011-02-16
  56. DUAL TARGETING OF MIR-208 AND MIR-499 IN THE TREATMENT OF CARDIAC DISORDERS
    Patent Number: EP2393945-A1; Date:2011-12-14
  57. Process for the production of fine chemicals
    Patent Number: WO2005014828-A2; Date:2005-02-17
  58. BIOMARKERS FOR CIRCULATING TUMOR CELLS
    Patent Number: EP2529223-A1; Date:2012-12-05
  59. MICRO-RNA AND TISSUE REPAIR
    Patent Number: WO2011064354-A2; Date:2011-06-03
  60. COMPOSITIONS FOR USE IN TREATING OR PREVENTING CANCER, BREAST CANCER, LUNG CANCER, OVARIAN CANCER, METASTASIS, HEART FAILURE, CARDIAC REMODELLING, DILATED CARDIOMYOPATHY, AUTOIMMUNE DISEASES, OR DISEASES OR DISORDERS RELATED THERETO
    Patent Number: WO2011157294-A1; Date:2011-12-22
  61. METHODS AND COMPOSITIONS FOR INACTIVATING GLUTAMINE SYNTHETASE GENE EXPRESSION
    Patent Number: EP2344660-A2; Date:2011-07-20
  62. Lysosomal associated membrane protein (LAMP) - like polypeptide, ligands to the same, and use of the same in the frame of detection and purification of human plasmacytoid dendritic cells
    Patent Number: EP1932854-A1; Date:2008-06-18