common platanna


Alias: platanna, African clawed frog, clawed frog, Xenopus laevis, Xenopus leavis, Bufo laevis, Xenopus laevis (Daudin, 1802)

Top Publications

  1. Leung L, Urbančič V, Baudet M, Dwivedy A, Bayley T, Lee A, et al. Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation. Nat Neurosci. 2013;16:166-73 pubmed publisher the mid-dorsal optic tract neuroepithelium and in the axons of developing retinal ganglion cells (RGC) in Xenopus laevis. Here we report that targeted disruption of NFPC function in RGC axons or the optic tract neuroepithelium ..
  2. Tadjuidje E, Cha S, Louza M, Wylie C, Heasman J. The functions of maternal Dishevelled 2 and 3 in the early Xenopus embryo. Dev Dyn. 2011;240:1727-36 pubmed publisher
    Of the three Dishevelled (Dvl) genes, only Dvl2 and Dvl3 are maternally encoded in the frog, Xenopus laevis. We show here by loss of function analysis that single depletion of either Dvl2 or Dvl3 from the oocyte causes the same embryonic ..
  3. Law A, Vehlow A, Kotini M, Dodgson L, Soong D, Theveneau E, et al. Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo. J Cell Biol. 2013;203:673-89 pubmed publisher
    ..Consistently, Lpd regulates mesenchymal neural crest cell migration cell autonomously in Xenopus laevis via the Scar/WAVE complex...
  4. D Amico L, Boujard D, Coumailleau P. The neurogenic factor NeuroD1 is expressed in post-mitotic cells during juvenile and adult Xenopus neurogenesis and not in progenitor or radial glial cells. PLoS ONE. 2013;8:e66487 pubmed publisher
    ..Importantly, we provided evidence that NeuroD1-expressing cells at this brain developmental stage were post-mitotic (PCNA-) cells and not radial glial (Vimentin+) or progenitors (Sox2+) cells. ..
  5. Klos Dehring D, Vladar E, Werner M, Mitchell J, Hwang P, Mitchell B. Deuterosome-mediated centriole biogenesis. Dev Cell. 2013;27:103-12 pubmed publisher
    ..However, in CCDC78 morphants, Cep152 fails to localize to the deuterosome and centriole biogenesis is impaired, indicating that CCDC78-mediated recruitment of Cep152 is required for deuterosome-mediated centriole biogenesis. ..
  6. Poh W, Chadha G, Gillespie P, Kaldis P, Blow J. Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1. Open Biol. 2014;4:130138 pubmed publisher
  7. Kuriyama S, Theveneau E, Benedetto A, Parsons M, Tanaka M, Charras G, et al. In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. J Cell Biol. 2014;206:113-27 pubmed publisher
    ..This change of plasticity allows cells to migrate under physical constraints without abolishing cell cooperation required for collectiveness. ..
  8. Koehler A, Schlupf J, Schneider M, Kraft B, Winter C, Kashef J. Loss of Xenopus cadherin-11 leads to increased Wnt/?-catenin signaling and up-regulation of target genes c-myc and cyclin D1 in neural crest. Dev Biol. 2013;383:132-45 pubmed publisher
  9. Moore R, Theveneau E, Pozzi S, Alexandre P, Richardson J, Merks A, et al. Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion. Development. 2013;140:4763-75 pubmed publisher
    ..Our results demonstrate a novel role of Par3 during neural crest migration, which is likely to be conserved in other processes that involve CIL such as cancer invasion or cell dispersion. ..

More Information

Publications120 found, 100 shown here

  1. Lowery L, Stout A, Faris A, Ding L, Baird M, Davidson M, et al. Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth. Neural Dev. 2013;8:22 pubmed publisher
    ..we use quantitative analysis of high-resolution live imaging to examine the function of XMAP215 in embryonic Xenopus laevis neurons...
  2. Becker S, Mayor R, Kashef J. Cadherin-11 mediates contact inhibition of locomotion during Xenopus neural crest cell migration. PLoS ONE. 2013;8:e85717 pubmed publisher
    ..Blocking Wnt/PCP signaling led to similar results underlining the importance of Xcad-11 in the mechanism of CIL and directional migration of CNC. ..
  3. Sako K, Suzuki K, Isoda M, Yoshikai S, Senoo C, Nakajo N, et al. Emi2 mediates meiotic MII arrest by competitively inhibiting the binding of Ube2S to the APC/C. Nat Commun. 2014;5:3667 pubmed publisher
    ..Thus, Emi2 competitively inhibits APC/C-Ube2S binding before fertilization, while its degradation on fertilization relieves the inhibition for APC/C activation. ..
  4. Barriga E, Maxwell P, Reyes A, Mayor R. The hypoxia factor Hif-1? controls neural crest chemotaxis and epithelial to mesenchymal transition. J Cell Biol. 2013;201:759-76 pubmed publisher
    ..Inhibition of Hif-1? by antisense morpholinos in Xenopus laevis or zebrafish embryos led to complete inhibition of neural crest migration...
  5. Reber S, Baumgart J, Widlund P, Pozniakovsky A, Howard J, Hyman A, et al. XMAP215 activity sets spindle length by controlling the total mass of spindle microtubules. Nat Cell Biol. 2013;15:1116-22 pubmed publisher the enzymatic activity of XMAP215, a processive microtubule polymerase, we show that Xenopus laevis spindle length increases linearly with microtubule growth velocity, whereas other parameters of spindle ..
  6. Tandon P, Miteva Y, Kuchenbrod L, Cristea I, Conlon F. Tcf21 regulates the specification and maturation of proepicardial cells. Development. 2013;140:2409-21 pubmed publisher
    ..Collectively, these studies lead us to propose that Tcf21 functions as a transcriptional repressor to regulate proepicardial cell specification and the correct formation of a mature epithelial epicardium. ..
  7. Ciau Uitz A, Pinheiro P, Kirmizitas A, Zuo J, Patient R. VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus. Development. 2013;140:2632-42 pubmed publisher
    ..Thus, detailed temporal, epistatic measurements of key TFs and VEGFA plus its receptor have enabled us to build a Xenopus adult haemangioblast GRN. ..
  8. Ali F, Cheng K, Kirwan P, Metcalfe S, Livesey F, Barker R, et al. The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development. 2014;141:2216-24 pubmed publisher
  9. Marx A, Godinez W, Tsimashchuk V, Bankhead P, Rohr K, Engel U. Xenopus cytoplasmic linker-associated protein 1 (XCLASP1) promotes axon elongation and advance of pioneer microtubules. Mol Biol Cell. 2013;24:1544-58 pubmed publisher
    ..Lamellipodial architecture depended on XCLASP1 and its capacity to associate with MTs, highlighting the importance of XCLASP1 in actin-microtubule interactions. ..
  10. Revinski D, Paganelli A, Carrasco A, López S. Delta-Notch signaling is involved in the segregation of the three germ layers in Xenopus laevis. Dev Biol. 2010;339:477-92 pubmed publisher
    ..Moreover, Notch activity must be modulated at appropriate levels during this process in order to keep normal morphogenetic movements during gastrulation...
  11. Lander R, Nasr T, Ochoa S, Nordin K, Prasad M, LaBonne C. Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation. Nat Commun. 2013;4:1542 pubmed publisher
    ..Together, these findings elucidate a mechanism for coordinated control of a group of structurally diverse factors that function as a regulatory unit in both developmental and pathological epithelial-mesenchymal transitions...
  12. Li X, Han D, Kin Ting Kam R, Guo X, Chen M, Yang Y, et al. Developmental expression of sideroflexin family genes in Xenopus embryos. Dev Dyn. 2010;239:2742-7 pubmed publisher
    ..As the primary structures of the five sideroflexin proteins are also quite similar, their functional redundancy should be taken into consideration for gene targeting studies. ..
  13. Zeng W, Kong Q, Li C, Mao B. Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation. Biochem Biophys Res Commun. 2010;394:1024-9 pubmed publisher
    ..These data reveal a RCOR2/ZMYND8 complex which might be involved in the regulation of neural differentiation. ..
  14. Kumagai A, Shevchenko A, Shevchenko A, Dunphy W. Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J Cell Biol. 2011;193:995-1007 pubmed publisher
    ..Association between Treslin and TopBP1 requires cyclin-dependent kinase (Cdk) activity in Xenopus laevis egg extracts. We investigated the mechanism and functional importance of Cdk for this interaction using both X...
  15. Hao H, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature. 2012;485:195-200 pubmed publisher
    ..These data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3. Our study provides new mechanistic insights into the regulation of Wnt receptor turnover, and reveals ZNRF3 as a tractable target for therapeutic exploration...
  16. Konno N, Fujii Y, Imae H, Kaiya H, Mukuda T, Miyazato M, et al. Urotensin II receptor (UTR) exists in hyaline chondrocytes: a study of peripheral distribution of UTR in the African clawed frog, Xenopus laevis. Gen Comp Endocrinol. 2013;185:44-56 pubmed publisher
    ..elucidating the actions of UII and URP in amphibians, we cloned and characterized URP and UTR from the African clawed frog Xenopus laevis...
  17. Kraft B, Berger C, Wallkamm V, Steinbeisser H, Wedlich D. Wnt-11 and Fz7 reduce cell adhesion in convergent extension by sequestration of PAPC and C-cadherin. J Cell Biol. 2012;198:695-709 pubmed publisher
    Wnt-11/planar cell polarity signaling polarizes mesodermal cells undergoing convergent extension during Xenopus laevis gastrulation...
  18. Agrawal R, Tran U, Wessely O. The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1. Development. 2009;136:3927-36 pubmed publisher
    ..However, in the absence of miR-30 activity, Xlim1/Lhx1 is maintained at high levels and, therefore, may contribute to the delayed terminal differentiation of the amphibian pronephros. ..
  19. Hashimoto Y, Ray Chaudhuri A, Lopes M, Costanzo V. Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol. 2010;17:1305-11 pubmed publisher
    ..Here, using EM to visualize replication intermediates assembled in Xenopus laevis egg extract, we show that Rad51 is required to prevent the accumulation of single-stranded DNA (ssDNA) gaps at ..
  20. Isoda M, Sako K, Suzuki K, Nishino K, Nakajo N, Ohe M, et al. Dynamic regulation of Emi2 by Emi2-bound Cdk1/Plk1/CK1 and PP2A-B56 in meiotic arrest of Xenopus eggs. Dev Cell. 2011;21:506-19 pubmed publisher
    ..Thus, Emi2 stability and activity are dynamically regulated by Emi2-bound multiple kinases and PP2A phosphatase. Our data also suggest a general role for Cdk1 substrate phosphorylation motifs in M phase regulation. ..
  21. Ouyang M, Lu S, Kim T, Chen C, Seong J, Leckband D, et al. N-cadherin regulates spatially polarized signals through distinct p120ctn and ?-catenin-dependent signalling pathways. Nat Commun. 2013;4:1589 pubmed publisher
    ..We hence conclude that N-cadherin couples with distinct effectors to polarize phosphoinositide 3-kinase/Rac and myosin II light chain/actin filaments in migrating cells...
  22. Bajpai R, Chen D, Rada Iglesias A, Zhang J, Xiong Y, Helms J, et al. CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature. 2010;463:958-62 pubmed publisher
  23. Drinjakovic J, Jung H, Campbell D, Strochlic L, Dwivedy A, Holt C. E3 ligase Nedd4 promotes axon branching by downregulating PTEN. Neuron. 2010;65:341-57 pubmed publisher
    ..Together our data suggest that Nedd4-regulated PTEN is a key regulator of terminal arborization in vivo. ..
  24. Cousin H, Abbruzzese G, Kerdavid E, Gaultier A, Alfandari D. Translocation of the cytoplasmic domain of ADAM13 to the nucleus is essential for Calpain8-a expression and cranial neural crest cell migration. Dev Cell. 2011;20:256-63 pubmed publisher
    ..This study shows that the cytoplasmic domain of ADAM metalloproteases can perform essential functions in the nucleus of cells and may contribute substantially to the overall function of the protein. ..
  25. Eckerdt F, Yamamoto T, Lewellyn A, Maller J. Identification of a polo-like kinase 4-dependent pathway for de novo centriole formation. Curr Biol. 2011;21:428-32 pubmed publisher
    ..The results define a new system for studying the biochemical and molecular basis of de novo centriole formation and centriole biogenesis in general. ..
  26. Ciau Uitz A, Pinheiro P, Gupta R, Enver T, Patient R. Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling. Dev Cell. 2010;18:569-78 pubmed publisher
    ..Few such links between intrinsic and extrinsic programming of stem cells have been reported previously. Our data place Tel1/ETV6 at the apex of the genetic regulatory cascade leading to HSC production. ..
  27. Schneider M, Schambony A, Wedlich D. Prohibitin1 acts as a neural crest specifier in Xenopus development by repressing the transcription factor E2F1. Development. 2010;137:4073-81 pubmed publisher
    ..With the Xphb1 dependency of a subset of CNC specifiers downstream of c-myc, we have identified a new branching point in the neural crest gene regulatory network. ..
  28. Chen X, Koh E, Yoder M, Gumbiner B. A protocadherin-cadherin-FLRT3 complex controls cell adhesion and morphogenesis. PLoS ONE. 2009;4:e8411 pubmed publisher
  29. Wen L, Yang Y, Wang Y, Xu A, Wu D, Chen Y. Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells. Dev Dyn. 2010;239:2198-207 pubmed publisher
    ..Together, our data suggest that appl1-akt signaling is specifically required for the survival of pancreas and SD progenitor cells in Xenopus laevis embryos.
  30. Elkouby Y, Elias S, Casey E, Blythe S, Tsabar N, Klein P, et al. Mesodermal Wnt signaling organizes the neural plate via Meis3. Development. 2010;137:1531-41 pubmed publisher
    ..This suggests a new model for neural anteroposterior patterning, in which Wnt3a from the paraxial mesoderm induces posterior cell fates via direct activation of a crucial transcription factor in the overlying neural plate...
  31. Mochida S, Maslen S, Skehel M, Hunt T. Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Science. 2010;330:1670-3 pubmed publisher
    ..This converts Ensa into a potent and specific inhibitor of PP2A-B55?. This pathway represents a previously unknown element in the control of mitosis. ..
  32. Walentek P, Beyer T, Thumberger T, Schweickert A, Blum M. ATP4a is required for Wnt-dependent Foxj1 expression and leftward flow in Xenopus left-right development. Cell Rep. 2012;1:516-27 pubmed publisher
    ..Specifically, ATP4 was required for Wnt/?-catenin-regulated Foxj1 induction and Wnt/PCP-dependent cilia polarization. Our work argues for evolutionary conservation of symmetry breakage in the vertebrates. ..
  33. Wilbur J, Heald R. Mitotic spindle scaling during Xenopus development by kif2a and importin ?. elife. 2013;2:e00290 pubmed publisher
    ..To identify mechanisms that scale the spindle during Xenopus laevis embryogenesis, we established an in vitro system using cytoplasmic extracts prepared from embryos that ..
  34. Peng A, Lewellyn A, Schiemann W, Maller J. Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation. Curr Biol. 2010;20:387-96 pubmed publisher
    ..We report essential DDR regulation mediated by Repo-Man-PP1 and further delineate underlying mechanisms. Moreover, our evidence suggests that elevated Repo-Man contributes to cancer progression. ..
  35. Levy D, Heald R. Nuclear size is regulated by importin ? and Ntf2 in Xenopus. Cell. 2010;143:288-98 pubmed publisher
    ..We investigated nuclear scaling in the pseudotetraploid frog Xenopus laevis and its smaller diploid relative Xenopus tropicalis, which contains smaller cells and nuclei...
  36. Sirour C, Hidalgo M, Bello V, Buisson N, Darribère T, Moreau N. Dystroglycan is involved in skin morphogenesis downstream of the Notch signaling pathway. Mol Biol Cell. 2011;22:2957-69 pubmed publisher
    ..We used a morpholino knockdown approach to investigate the function of Dg during Xenopus laevis skin morphogenesis...
  37. Kim K, Lake B, Haremaki T, Weinstein D, Sokol S. Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis. Dev Dyn. 2012;241:1385-95 pubmed publisher
    ..As Rab11-dependent vesicle trafficking has been implicated in ciliary membrane assembly and in apical domain formation in epithelial cells, we assessed the involvement of Rab11 in MCC development...
  38. Gharbi Ayachi A, Labbé J, Burgess A, Vigneron S, Strub J, Brioudes E, et al. The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. Science. 2010;330:1673-7 pubmed publisher
    ..Although both proteins can inhibit PP2A, endogenous Arpp19, but not ?-Endosulfine, is responsible for PP2A inhibition at mitotic entry in Xenopus egg extracts. ..
  39. Bernad R, Sanchez P, Rivera T, Rodríguez Corsino M, Boyarchuk E, Vassias I, et al. Xenopus HJURP and condensin II are required for CENP-A assembly. J Cell Biol. 2011;192:569-82 pubmed publisher
    ..We propose that the chromatin structure imposed by condensin II at centromeres enables CENP-A incorporation initiated by xHJURP. ..
  40. Tsuchiya Y, Yamashita S. Anti-apoptotic activity and proteasome-mediated degradation of Xenopus Mcl-1 protein in egg extracts. J Biol Chem. 2011;286:15806-14 pubmed publisher
    ..Our results suggest that the proteolytic decay of xMcl-1 may change the functional balance between pro- and anti-apoptotic activities of Bcl-2 family proteins, thereby regulating the timing of cytochrome c release in egg extracts. ..
  41. Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, et al. Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development. 2011;138:4267-77 pubmed publisher
    ..From these results, we propose a model whereby multi-site cdk-dependent phosphorylation of Ngn2 interprets cdk levels to control neuronal differentiation in response to cell cycle lengthening during development. ..
  42. Cousin H, Abbruzzese G, McCusker C, Alfandari D. ADAM13 function is required in the 3 dimensional context of the embryo during cranial neural crest cell migration in Xenopus laevis. Dev Biol. 2012;368:335-44 pubmed publisher
    ..Together our results suggest that ADAM13 changes CNC interaction with the extracellular environment and that this change is necessary for their migration in vivo...
  43. Sun G, Hasebe T, Fujimoto K, Lu R, Fu L, Matsuda H, et al. Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis. PLoS ONE. 2010;5:e13605 pubmed publisher
    ..The T3-dependent metamorphosis in anurans like Xenopus laevis resembles the mammalian postembryonic development and offers a unique opportunity to study how the adult stem ..
  44. Ohkawara B, Niehrs C. An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos. Dev Dyn. 2011;240:188-94 pubmed publisher
    ..We also mapped Wnt/PCP signaling in the early Xenopus embryo and find that it peaks in the dorso-vegetal region, paralleling Wnt/?-catenin signaling. ..
  45. Kerstein P, Jacques Fricke B, Rengifo J, Mogen B, Williams J, Gottlieb P, et al. Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth. J Neurosci. 2013;33:273-85 pubmed publisher
    ..Together our results suggest that Ca(2+) influx through MS TRPC1 on filopodia activates calpain to control growth cone turning during development...
  46. Yamaguchi Y, Hayashi A, Campagnoni C, Kimura A, Inuzuka T, Baba H. L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough. J Biol Chem. 2012;287:17765-76 pubmed publisher
    ..Since this is the first finding of stop codon readthrough in a common mammalian protein, detailed analysis of L-MPZ expression will help to understand the mechanism of stop codon readthrough in mammals. ..
  47. Giesecke A, Stewart M. Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-alpha. J Biol Chem. 2010;285:17628-35 pubmed publisher
    ..The different way in which TPX2 binds to importin-alpha could account for much of the selectivity necessary during mitosis because this would reduce the competition for binding to importin-alpha from other NLS-containing proteins. ..
  48. Kim Y, Holland A, Lan W, Cleveland D. Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell. 2010;142:444-55 pubmed publisher
  49. Loughlin R, Wilbur J, McNally F, N d lec F, Heald R. Katanin contributes to interspecies spindle length scaling in Xenopus. Cell. 2011;147:1397-407 pubmed publisher
    ..Thus, mechanisms have evolved in different species to scale spindle size and coordinate regulation of multiple MT populations in order to generate a robust steady-state structure...
  50. Knipscheer P, Raschle M, Smogorzewska A, Enoiu M, Ho T, SCHARER O, et al. The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science. 2009;326:1698-701 pubmed publisher
    ..Reversal of these defects requires ubiquitylated FANCI-FANCD2. Our results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia pathway is compromised...
  51. Morita H, Nandadasa S, Yamamoto T, Terasaka Iioka C, Wylie C, Ueno N. Nectin-2 and N-cadherin interact through extracellular domains and induce apical accumulation of F-actin in apical constriction of Xenopus neural tube morphogenesis. Development. 2010;137:1315-25 pubmed publisher
    ..We propose a novel mechanism of neural tube morphogenesis regulated by the two types of cell adhesion molecules. ..
  52. Satow R, Shitashige M, Jigami T, Honda K, Ono M, Hirohashi S, et al. Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation. J Biol Chem. 2010;285:26289-94 pubmed publisher
    ..These results demonstrate that XTNIK is an essential factor for the transcriptional activity of the beta-catenin-TCF complex and dorsal axis determination in Xenopus embryos. ..
  53. Kisielewska J, Blow J. Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos. Development. 2012;139:63-74 pubmed publisher
  54. Kietzmann A, Wang Y, Weber D, Steinbeisser H. Xenopus paraxial protocadherin inhibits Wnt/?-catenin signalling via casein kinase 2?. EMBO Rep. 2012;13:129-34 pubmed publisher
    ..By this mechanism, PAPC restricts the expression of Wnt target genes during gastrulation. These experiments identify a novel function of protocadherins as regulators of the Wnt pathway. ..
  55. Gutkovich Y, Ofir R, Elkouby Y, Dibner C, Gefen A, Elias S, et al. Xenopus Meis3 protein lies at a nexus downstream to Zic1 and Pax3 proteins, regulating multiple cell-fates during early nervous system development. Dev Biol. 2010;338:50-62 pubmed publisher
    ..Thus, XMeis3 protein is positioned at a key regulatory point, simultaneously regulating multiple neural cell fates during early vertebrate nervous system development. ..
  56. Park B, Saint Jeannet J. Expression analysis of Runx3 and other Runx family members during Xenopus development. Gene Expr Patterns. 2010;10:159-66 pubmed publisher
    ..These observations suggest a critical role for Runx3 in the development of cranial sensory neurons, while in other tissues its co-expression with Runx1 or Runx2 may signify functional redundancy between these family members. ..
  57. Pearl E, Jarikji Z, Horb M. Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes. Dev Biol. 2011;351:135-45 pubmed publisher
    ..In early development Rfx6 plays a broad role, being essential for development of most anterior endodermal organs. At later stages however, Rfx6 function is restricted to endocrine cells. ..
  58. Zyłkiewicz E, Kijanska M, Choi W, Derewenda U, Derewenda Z, Stukenberg P. The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein. J Cell Biol. 2011;192:433-45 pubmed publisher
    ..Together, our results provide important insights into how Ndel1 acts as a regulated scaffold to temporally and spatially regulate dynein. ..
  59. Lorca T, Bernis C, Vigneron S, Burgess A, Brioudes E, Labbé J, et al. Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle. J Cell Sci. 2010;123:2281-91 pubmed publisher
  60. Wang S, Zheng Y. Identification of a novel dynein binding domain in nudel essential for spindle pole organization in Xenopus egg extract. J Biol Chem. 2011;286:587-93 pubmed publisher
    ..Together, our findings open up new avenues to further decipher the mechanism of dynein regulation by Nudel and Lis1. ..
  61. Leblanc J, Zhang X, McKee D, Wang Z, Li R, Ma C, et al. The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization. Mol Hum Reprod. 2011;17:305-16 pubmed publisher
    ..Therefore, Cdc42 activation likely promotes membrane protrusion during polar body emission in widespread systems. ..
  62. Wilczek C, Chitta R, Woo E, Shabanowitz J, Chait B, Hunt D, et al. Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs. J Biol Chem. 2011;286:42221-31 pubmed publisher
    ..In the maturing oocytes and eggs of the frog Xenopus laevis, histones are synthesized in bulk in preparation for deposition during the rapid early developmental cell ..
  63. Fujimoto K, Matsuura K, Hu Wang E, Lu R, Shi Y. Thyroid hormone activates protein arginine methyltransferase 1 expression by directly inducing c-Myc transcription during Xenopus intestinal stem cell development. J Biol Chem. 2012;287:10039-50 pubmed publisher
    ..These results suggest that T3 induces c-Myc transcription directly in the intestine, that c-Myc, in turn, activates PRMT1 expression, and that this is an important gene regulation cascade controlling intestinal stem cell development. ..
  64. Labit H, Fujimitsu K, Bayin N, Takaki T, Gannon J, Yamano H. Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C. EMBO J. 2012;31:3351-62 pubmed publisher
    ..Furthermore, we show that the 'activation domain' of Cdc20 associates with the Apc6 and Apc8 core subunits. Our data suggest that dephosphorylation of Cdc20 is required for its loading and activation of the APC/C ubiquitin ligase. ..
  65. Jung B, Köhler A, Schambony A, Wedlich D. PAPC and the Wnt5a/Ror2 pathway control the invagination of the otic placode in Xenopus. BMC Dev Biol. 2011;11:36 pubmed publisher
  66. Ramirez Gordillo D, Trujillo Provencio C, Knight V, Serrano E. Optimization of gene delivery methods in Xenopus laevis kidney (A6) and Chinese hamster ovary (CHO) cell lines for heterologous expression of Xenopus inner ear genes. In Vitro Cell Dev Biol Anim. 2011;47:640-52 pubmed publisher
    ..Our findings demonstrate the need to improve gene delivery methods for amphibian cells and underscore the necessity for a greater understanding of amphibian cell biology. ..
  67. Wawrousek K, Fortini B, Polaczek P, Chen L, Liu Q, Dunphy W, et al. Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM. Cell Cycle. 2010;9:1156-66 pubmed
    We have used the Xenopus laevis egg extract system to study the roles of vertebrate Dna2 in DNA replication and double-strand-break (DSB) repair.  We first establish that Xenopus Dna2 is a helicase, as well as a nuclease...
  68. Suzuki M, Hara Y, Takagi C, Yamamoto T, Ueno N. MID1 and MID2 are required for Xenopus neural tube closure through the regulation of microtubule organization. Development. 2010;137:2329-39 pubmed publisher
    ..We propose that similar MID-governed mechanisms underlie the normal morphogenesis of epithelial tissues and organs, including the tissues affected in patients with Opitz G/BBB syndrome. ..
  69. Ryu H, Al Ani G, Deckert K, Kirkpatrick D, Gygi S, Dasso M, et al. PIASy mediates SUMO-2/3 conjugation of poly(ADP-ribose) polymerase 1 (PARP1) on mitotic chromosomes. J Biol Chem. 2010;285:14415-23 pubmed publisher
    ..However, loss of SUMOylation increased PARP1-dependent PARylation on isolated chromosomes, indicating SUMOylation controls the capacity of PARP1 to modify other chromatin-associated proteins. ..
  70. Schweickert A, Vick P, Getwan M, Weber T, Schneider I, Eberhardt M, et al. The nodal inhibitor Coco is a critical target of leftward flow in Xenopus. Curr Biol. 2010;20:738-43 pubmed publisher
    ..Coco thus acts as a critical target of flow, suggesting that symmetry is broken by flow-mediated left-asymmetric release of Nodal repression at the midline. ..
  71. Miyamoto K, Pasque V, Jullien J, Gurdon J. Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. Genes Dev. 2011;25:946-58 pubmed publisher
    ..This is the first report showing that naturally stored actin in an oocyte nucleus helps transcriptional reprogramming in a polymerization-dependent manner. ..
  72. Fonar Y, Gutkovich Y, Root H, Malyarova A, Aamar E, Golubovskaya V, et al. Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate. Mol Biol Cell. 2011;22:2409-21 pubmed publisher
    ..However, little is known about its normal embryonic function. FAK protein knockdown during early Xenopus laevis development anteriorizes the embryo...
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