Alias: zebra danio, zebra fish, Danio rerio, Brachydanio rerio, Brachidanio rerio, leopard danio, Brachydanio rerio frankei, Cyprinus rerio, Cyprinus rerio Hamilton, 1822, Danio frankei, Danio rerio (Hamilton, 1822), Danio rerio frankei

Top Publications

  1. Balow S, Pierce L, Zentner G, Conrad P, Davis S, Sabaawy H, et al. Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome. Dev Biol. 2013;382:57-69 pubmed publisher
    ..To examine the role of Chd7 in development, a zebrafish model was generated through morpholino (MO)-mediated targeting of the zebrafish chd7 transcript...
  2. Kim J, Kang Y, Kim J, Papangeli I, Kang H, Wu J, et al. Essential role of Apelin signaling during lymphatic development in zebrafish. Arterioscler Thromb Vasc Biol. 2014;34:338-45 pubmed publisher
    ..We investigated the functions of Apelin signaling during lymphatic development using zebrafish embryos and found that attenuation of Apelin signaling substantially decreased the formation of the parachordal ..
  3. Pistocchi A, Fazio G, Cereda A, Ferrari L, Bettini L, Messina G, et al. Cornelia de Lange Syndrome: NIPBL haploinsufficiency downregulates canonical Wnt pathway in zebrafish embryos and patients fibroblasts. Cell Death Dis. 2013;4:e866 pubmed publisher
    ..The present study focuses on the role of the zebrafish nipblb paralog during neural development, examining its expression in the central nervous system, and analyzing ..
  4. Miyares R, Stein C, Renisch B, Anderson J, Hammerschmidt M, Farber S. Long-chain Acyl-CoA synthetase 4A regulates Smad activity and dorsoventral patterning in the zebrafish embryo. Dev Cell. 2013;27:635-47 pubmed publisher
    ..acyl-CoA synthetase 4a (Acsl4a), an LC-PUFA activating enzyme, is essential for proper patterning of the zebrafish dorsoventral axis...
  5. DeMaria S, Berke A, Van Name E, Heravian A, Ferreira T, Ngai J. Role of a ubiquitously expressed receptor in the vertebrate olfactory system. J Neurosci. 2013;33:15235-47 pubmed publisher
    ..unlike most other odorant receptors, is expressed in a large population of microvillous sensory neurons in the zebrafish olfactory epithelium and the mouse vomeronasal organ...
  6. Groh K, Schönenberger R, Eggen R, Segner H, Suter M. Analysis of protein expression in zebrafish during gonad differentiation by targeted proteomics. Gen Comp Endocrinol. 2013;193:210-20 pubmed publisher
    The molecular mechanisms governing sex determination and differentiation in the zebrafish (Danio rerio) are not fully understood...
  7. Fleming A, Diekmann H, Goldsmith P. Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS ONE. 2013;8:e77548 pubmed publisher
    b>Zebrafish are becoming increasingly popular as an organism in which to model human disease and to study the effects of small molecules on complex physiological and pathological processes...
  8. Jacob J, Ribes V, Moore S, Constable S, Sasai N, Gerety S, et al. Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome. Dis Model Mech. 2014;7:107-17 pubmed publisher
    ..Here we have used a chemical-genetics approach to investigate the underlying molecular defect in a zebrafish FVS model. Valproate causes the selective failure of zebrafish central serotonin expression...
  9. Huang W, Yang C, Chen I, Liu Y, Chang S, Chuang Y. Treatment of Glucocorticoids Inhibited Early Immune Responses and Impaired Cardiac Repair in Adult Zebrafish. PLoS ONE. 2013;8:e66613 pubmed publisher
    Myocardial injury, such as myocardial infarction (MI), can lead to drastic heart damage. Zebrafish have the extraordinary ability to regenerate their heart after a severe injury...

More Information

Publications225 found, 100 shown here

  1. Iglesias A, Springelkamp H, van der Linde H, Severijnen L, Amin N, Oostra B, et al. Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age. Hum Mol Genet. 2014;23:1320-32 pubmed publisher
    ..Functional characterization of SIX6 in zebrafish revealed that knockdown of six6b led to a small eye phenotype...
  2. Fang L, Choi S, Baek J, Liu C, Almazan F, Ulrich F, et al. Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature. 2013;498:118-22 pubmed publisher
    ..Notably, Aibp, a zebrafish homologue of human AIBP, regulates the membrane lipid order in embryonic zebrafish vasculature and functions as ..
  3. Howarth D, Yin C, Yeh K, Sadler K. Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae. Zebrafish. 2013;10:199-210 pubmed publisher
    ..We developed a series of straightforward assays to determine whether zebrafish larvae with either tunicamycin- or ethanol-induced steatosis develop hepatic dysfunction...
  4. Elks P, Brizee S, van der Vaart M, Walmsley S, van Eeden F, Renshaw S, et al. Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog. 2013;9:e1003789 pubmed publisher
    ..We sought to manipulate Hif-α signaling in a well-established Mycobacterium marinum (Mm) zebrafish model of TB to investigate effects on the host's ability to combat mycobacterial infection...
  5. Williams L, Timme Laragy A, Goldstone J, McArthur A, Stegeman J, Smolowitz R, et al. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS ONE. 2013;8:e79574 pubmed publisher
    ..We explored the expression and function of six nrf genes (nfe2, nrf1a, nrf1b, nrf2a, nrf2b, and nrf3) using zebrafish embryos as a model system...
  6. Kimura Y, Hisano Y, Kawahara A, Higashijima S. Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering. Sci Rep. 2014;4:6545 pubmed publisher
    ..Recently, targeted knock-in of a long DNA fragment via homology-independent DNA repair has been achieved in zebrafish using CRISPR/Cas9 system...
  7. Wong R, Oxendine S, Godwin J. Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment. BMC Genomics. 2013;14:348 pubmed publisher
    ..g. serotonergic or GABAergic effects). Zebrafish are an emerging and valuable translational model for understanding human health related issues such as anxiety...
  8. McCarthy N, Wetherill L, Lovely C, Swartz M, Foroud T, Eberhart J. Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. Development. 2013;140:3254-65 pubmed publisher
    ..We found that only platelet-derived growth factor receptor alpha (pdgfra) interacted with ethanol during zebrafish craniofacial development...
  9. Sonal -, Sidhaye J, Phatak M, Banerjee S, Mulay A, Deshpande O, et al. Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis. PLoS Genet. 2014;10:e1004614 pubmed publisher
    ..We have used genetic analysis in combination with cellular imaging to show that zebrafish goosepimples/myosin Vb regulates plasma membrane homeostasis and is involved in maintenance of cell size in the ..
  10. Kim J, Kim J. Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish. Mol Cells. 2014;37:270-4 pubmed publisher
    ..the function of genes associated with Bone Morphogenetic Protein (BMP) signaling in lymphatic development using zebrafish embryos...
  11. Kurtenbach S, Prochnow N, Kurtenbach S, Klooster J, Zoidl C, Dermietzel R, et al. Pannexin1 channel proteins in the zebrafish retina have shared and unique properties. PLoS ONE. 2013;8:e77722 pubmed publisher
    ..Previously, we discovered that zebrafish lack Panx1 expression in the inner retina, with drPanx1a exclusively expressed in horizontal cells of the outer ..
  12. Zhao C, Andreeva V, Gibert Y, Labonty M, Lattanzi V, Prabhudesai S, et al. Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS Genet. 2014;10:e1004074 pubmed publisher
    ..Here we report a new zebrafish mutant, fantome (fan), which harbors a point mutation and predicted premature stop codon in zebrafish wdr43, the ..
  13. Wong T, Tesfamichael A, Collodi P. Identification of promoter elements responsible for gonad-specific expression of zebrafish Deadend and its application to ovarian germ cell derivation. Int J Dev Biol. 2013;57:767-72 pubmed publisher
    We discovered that a 150-bp region of zebrafish deadend (dnd) spanning the translation start codon, exon 1 and part of intron 1 is required to direct heterologous neomycin-resistance gene (neo) expression specifically in the gonad, ..
  14. Evans M, Smart N, Dubé K, Bollini S, Clark J, Evans H, et al. Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing. Nat Commun. 2013;4:2081 pubmed publisher
    ..In zebrafish, hydrogen peroxide released from a wound is the initial instructive chemotactic cue for the infiltration of ..
  15. Zhang M, Kothari P, Mullins M, Lampson M. Regulation of zygotic genome activation and DNA damage checkpoint acquisition at the mid-blastula transition. Cell Cycle. 2014;13:3828-38 pubmed publisher
    ..We show that precocious Chk1 activity in pre-MBT zebrafish embryos elongates cleavage cycles, thereby slowing the increase in the N:C ratio...
  16. Moore R, Theveneau E, Pozzi S, Alexandre P, Richardson J, Merks A, et al. Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion. Development. 2013;140:4763-75 pubmed publisher
    ..We show in Xenopus and zebrafish that Par3 is localised to the cell-cell contact in neural crest cells and is essential for CIL...
  17. Wong T, Tesfamichael A, Collodi P. Production of zebrafish offspring from cultured female germline stem cells. PLoS ONE. 2013;8:e62660 pubmed publisher
    b>Zebrafish female germline stem cell (FGSC) cultures were generated from a transgenic line of fish that expresses Neo and DsRed under the control of the germ cell specific promoter, ziwi [Tg(ziwi:neo);Tg(ziwi:DsRed)]...
  18. Flasse L, Pirson J, Stern D, Von Berg V, Manfroid I, Peers B, et al. Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish. BMC Biol. 2013;11:78 pubmed publisher
    ..We show that, in zebrafish, neurog3 is not expressed in the pancreas and null neurog3 mutant embryos do not display any apparent endocrine ..
  19. Kang J, Nachtrab G, Poss K. Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins. Dev Cell. 2013;27:19-31 pubmed publisher
    ..produced by dense regions of androgen-regulated epidermal tubercles (ETs) on the surfaces of adult male zebrafish pectoral fins...
  20. Gabor K, Stevens C, Pietraszewski M, Gould T, Shim J, Yoder J, et al. Super resolution microscopy reveals that caveolin-1 is required for spatial organization of CRFB1 and subsequent antiviral signaling in zebrafish. PLoS ONE. 2013;8:e68759 pubmed publisher
    ..Viral infection leads to a downregulation in Caveolin-1b (Cav-1b), disrupting clusters of CRFB1, a zebrafish type I interferon receptor (-R) subunit...
  21. MacDonald R, Pollack J, Debiais Thibaud M, Heude E, Talbot J, Ekker M. The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon. Dev Biol. 2013;381:276-85 pubmed publisher
    ..Here, we have examined the regulatory relationships between the ascl1a, dlx, and gad1b genes in the zebrafish forebrain...
  22. Kamel G, Hoyos T, Rochard L, Dougherty M, Kong Y, Tse W, et al. Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis. Dev Biol. 2013;381:423-33 pubmed publisher
    ..lower jaw structures, and integration of wnt-frizzled with endothelin signaling to coordinate shaping of the facial form. ..
  23. Patterson L, Parichy D. Interactions with iridophores and the tissue environment required for patterning melanophores and xanthophores during zebrafish adult pigment stripe formation. PLoS Genet. 2013;9:e1003561 pubmed publisher
    ..fundamental mechanisms of morphogenesis, differentiation, and pattern formation, and recent studies of zebrafish have started to elucidate the cellular interactions and molecular mechanisms underlying these processes...
  24. Sacilotto N, Monteiro R, Fritzsche M, Becker P, Sánchez del Campo L, Liu K, et al. Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development. Proc Natl Acad Sci U S A. 2013;110:11893-8 pubmed publisher
    ..Using both mouse and zebrafish models, we demonstrate here that arterial specification is regulated combinatorially by Notch signaling and SoxF ..
  25. Chetaille P, Preuss C, Burkhard S, Côté J, Houde C, Castilloux J, et al. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nat Genet. 2014;46:1245-9 pubmed publisher
    ..Morpholino-induced knockdown of sgol1 in zebrafish recapitulated the abnormalities seen in humans with CAID syndrome...
  26. Zhao X, Wan J, Powell C, Ramachandran R, Myers M, Goldman D. Leptin and IL-6 family cytokines synergize to stimulate Müller glia reprogramming and retina regeneration. Cell Rep. 2014;9:272-284 pubmed publisher
    Unlike mammals, zebrafish can regenerate a damaged retina...
  27. Wada H, Ghysen A, Asakawa K, Abe G, Ishitani T, Kawakami K. Wnt/Dkk negative feedback regulates sensory organ size in zebrafish. Curr Biol. 2013;23:1559-65 pubmed publisher
    ..This study establishes Wnt/Dkk as a novel mechanism to determine the final size of an organ. ..
  28. Wang Y, Pascoe H, Brautigam C, He H, Zhang X. Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin. elife. 2013;2:e01279 pubmed publisher
    ..Here we present the crystal structures of the active dimer of zebrafish PlexinC1 cytoplasmic region in the apo state and in complex with Rap...
  29. Cavodeassi F, Ivanovitch K, Wilson S. Eph/Ephrin signalling maintains eye field segregation from adjacent neural plate territories during forebrain morphogenesis. Development. 2013;140:4193-202 pubmed publisher
    ..eyes and adjacent regions of the anterior neural plate during the early stages of forebrain morphogenesis in zebrafish. Several Ephrins and Ephs are expressed in complementary domains in the prospective forebrain and combinatorial ..
  30. Soroldoni D, Jörg D, Morelli L, Richmond D, Schindelin J, Jülicher F, et al. Genetic oscillations. A Doppler effect in embryonic pattern formation. Science. 2014;345:222-5 pubmed publisher
    ..However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation...
  31. Swift M, Pham V, Castranova D, Bell K, Poole R, Weinstein B. SoxF factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish. Dev Biol. 2014;390:116-25 pubmed publisher
    ..We have examined the role of nr2f2 during early arterial-venous development in the zebrafish trunk...
  32. Czopka T, Ffrench Constant C, Lyons D. Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo. Dev Cell. 2013;25:599-609 pubmed publisher
    ..We show, using live imaging in zebrafish, that oligodendrocytes make new myelin sheaths during a period of just 5 hr, with regulation of sheath number ..
  33. Frohnhöfer H, Krauss J, Maischein H, NUSSLEIN VOLHARD C. Iridophores and their interactions with other chromatophores are required for stripe formation in zebrafish. Development. 2013;140:2997-3007 pubmed publisher
    ..The zebrafish, Danio rerio, displays a striking pattern of dark stripes of melanophores interspersed by light stripes of xanthophores...
  34. McMenamin S, Bain E, McCann A, Patterson L, Eom D, Waller Z, et al. Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. Science. 2014;345:1358-61 pubmed publisher
    ..In zebrafish, several pigment cell classes interact to generate stripes, yet the developmental requirements and origins of ..
  35. Nikolaev A, Leung K, Odermatt B, Lagnado L. Synaptic mechanisms of adaptation and sensitization in the retina. Nat Neurosci. 2013;16:934-41 pubmed publisher
    ..What are the circuit mechanisms underlying this plasticity? We investigated how synapses in the retina of zebrafish adjust to changes in the temporal contrast of a visual stimulus by imaging activity in vivo...
  36. Bajard L, Morelli L, Ares S, Pecreaux J, Jülicher F, Oates A. Wnt-regulated dynamics of positional information in zebrafish somitogenesis. Development. 2014;141:1381-91 pubmed publisher
    ..Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation...
  37. Mahalwar P, Walderich B, Singh A, Nüsslein Volhard C. Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish. Science. 2014;345:1362-4 pubmed publisher
    The pattern of alternating blue and golden stripes displayed by adult zebrafish is composed of three kinds of pigment cells: black melanophores, yellow xanthophores, and silvery-blue iridophores...
  38. Reimer M, Norris A, Ohnmacht J, Patani R, Zhong Z, Dias T, et al. Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. Dev Cell. 2013;25:478-91 pubmed publisher
    ..projections from the brain promote motor neuron generation at the expense of V2 interneurons in the developing zebrafish spinal cord by activating the D4a receptor, which acts on the hedgehog pathway...
  39. Leichsenring M, Maes J, Mössner R, Driever W, Onichtchouk D. Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science. 2013;341:1005-9 pubmed publisher
    ..It is unknown whether a similar regulation exists in other animals. We found that zebrafish Pou5f1, a homolog of the mammalian pluripotency transcription factor Oct4, occupies SOX-POU binding sites before ..
  40. Lancman J, Zvenigorodsky N, Gates K, Zhang D, Solomon K, Humphrey R, et al. Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb. Development. 2013;140:2669-79 pubmed publisher
    ..Using a novel hypomorphic hnf1ba zebrafish mutant that exhibits pancreas hypoplasia, as observed in HNF1B monogenic diabetes, we show that hnf1ba plays ..
  41. Clay M, Halloran M. Rho activation is apically restricted by Arhgap1 in neural crest cells and drives epithelial-to-mesenchymal transition. Development. 2013;140:3198-209 pubmed publisher
    ..Our results provide new insight into mechanisms controlling local Rho activation and how it affects dynamic cell behaviors and actomyosin contraction during key steps of EMT in an intact living organism. ..
  42. Liu Y, Zhang Y, Liu T, Gui J. Lineage-specific expansion of IFIT gene family: an insight into coevolution with IFN gene family. PLoS ONE. 2013;8:e66859 pubmed publisher
    ..genes to IFN response is present early since the origin of both gene families, as evidenced by the finding that zebrafish IFIT genes are upregulated by fish IFNs, poly(I:C) and two transcription factors IRF3/IRF7, likely via the IFN-..
  43. Gupta V, Ravenscroft G, Shaheen R, Todd E, Swanson L, Shiina M, et al. Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy. Am J Hum Genet. 2013;93:1108-17 pubmed publisher
    ..Functional studies in zebrafish showed that loss of Klhl41 results in highly diminished motor function and myofibrillar disorganization, with ..
  44. Choe S, Ladam F, SAGERSTROM C. TALE factors poise promoters for activation by Hox proteins. Dev Cell. 2014;28:203-11 pubmed publisher
    ..Examining a Hoxb1b:TALE complex that regulates zebrafish hoxb1a transcription, we find maternally deposited TALE proteins at the hoxb1a promoter already during blastula ..
  45. Auer T, Duroure K, De Cian A, Concordet J, Del Bene F. Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome Res. 2014;24:142-53 pubmed publisher
    ..and the CRISPR/Cas9 system have greatly expanded the genome editing possibilities in model organisms such as zebrafish. Both systems have recently been used to create knock-out alleles with great efficiency, and TALENs have also ..
  46. Zhong J, Zhou L, Li Z, Wang Y, Gui J. Zebrafish Noxa promotes mitosis in early embryonic development and regulates apoptosis in subsequent embryogenesis. Cell Death Differ. 2014;21:1013-24 pubmed publisher
    ..In this study, we have studied the role of zebrafish Noxa (zNoxa) by using zNoxa-specifc morpholino knockdown and overexpression approaches in developing zebrafish ..
  47. Lee R, AshaRani P, Carney T. Basal keratinocytes contribute to all strata of the adult zebrafish epidermis. PLoS ONE. 2014;9:e84858 pubmed publisher
    ..Whilst mouse is the prime model system used for epidermal studies, there is increasing employment of the zebrafish to analyse epidermis development and homeostasis, however the architecture and ontogeny of the epidermis in this ..
  48. Phng L, Stanchi F, Gerhardt H. Filopodia are dispensable for endothelial tip cell guidance. Development. 2013;140:4031-40 pubmed publisher
    ..importance of F-actin in endothelial cells (ECs) during angiogenesis in vivo, we generated a transgenic zebrafish line expressing Lifeact-EGFP in ECs...
  49. Ignatius M, Unal Eroglu A, Malireddy S, Gallagher G, Nambiar R, Henion P. Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development. PLoS ONE. 2013;8:e63218 pubmed publisher
    ..Our study reveals distinct functional and temporal requirements for zebrafish hdac1 during neural crest-derived craniofacial and peripheral neuron development.
  50. Xu J, Zhang R, Shen Y, Liu G, Lu X, Wu C. The evolution of evolvability in microRNA target sites in vertebrates. Genome Res. 2013;23:1810-6 pubmed publisher
    ..The changing evolvability of miRNA targets suggests that miRNA-target interactions may play a role in the evolution of organismal diversity. ..
  51. Schiller V, Wichmann A, Kriehuber R, Schäfers C, Fischer R, Fenske M. Transcriptome alterations in zebrafish embryos after exposure to environmental estrogens and anti-androgens can reveal endocrine disruption. Reprod Toxicol. 2013;42:210-23 pubmed publisher
    ..investigated the application of a transcriptomics-based assay for estrogenic and anti-androgenic chemicals with zebrafish embryos...
  52. Long Y, Song G, Yan J, He X, Li Q, Cui Z. Transcriptomic characterization of cold acclimation in larval zebrafish. BMC Genomics. 2013;14:612 pubmed publisher
    ..In this study, we characterized the development of cold-tolerance in zebrafish larvae and investigated the transcriptional profiles under cold stress using RNA-seq...
  53. Lenkowski J, Qin Z, Sifuentes C, Thummel R, Soto C, Moens C, et al. Retinal regeneration in adult zebrafish requires regulation of TGF? signaling. Glia. 2013;61:1687-97 pubmed publisher
    ..Adult zebrafish Müller glia, in contrast, are considered tissue-specific stem cells that can self-renew and generate neurogenic ..
  54. Ravenscroft G, Miyatake S, Lehtokari V, Todd E, Vornanen P, Yau K, et al. Mutations in KLHL40 are a frequent cause of severe autosomal-recessive nemaline myopathy. Am J Hum Genet. 2013;93:6-18 pubmed publisher
    ..In zebrafish, klhl40a and klhl40b expression is largely confined to the myotome and skeletal muscle, and knockdown of these ..
  55. Moussavi Nik S, Croft K, Mori T, Lardelli M. The comparison of methods for measuring oxidative stress in zebrafish brains. Zebrafish. 2014;11:248-54 pubmed publisher
    The zebrafish is a versatile model organism with the potential to contribute to our understanding of the molecular pathological mechanisms underlying Alzheimer's disease (AD)...
  56. Solis G, Radon Y, Sempou E, Jechow K, Stuermer C, Malaga Trillo E. Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesion. PLoS ONE. 2013;8:e70327 pubmed publisher
    ..and human MCF-7 epithelial cells, and 2) the induction of PrP embryonic loss- and gain-of-function phenotypes in zebrafish. Our results show that homologous mutations in mouse and zebrafish PrPs similarly affect their subcellular ..
  57. Hwang W, Fu Y, Reyon D, Maeder M, Kaini P, Sander J, et al. Heritable and precise zebrafish genome editing using a CRISPR-Cas system. PLoS ONE. 2013;8:e68708 pubmed publisher
    ..RGN) system that can be used to efficiently and robustly introduce somatic indel mutations in endogenous zebrafish genes...
  58. Encinas P, Garcia Valtanen P, Chinchilla B, Gomez Casado E, Estepa A, Coll J. Identification of multipath genes differentially expressed in pathway-targeted microarrays in zebrafish infected and surviving spring viremia carp virus (SVCV) suggest preventive drug candidates. PLoS ONE. 2013;8:e73553 pubmed publisher
    ..Because the zebrafish (Danio rerio) is a cyprinid susceptible to SVCV and their genetics and genome sequence are well advanced, it has been chosen ..
  59. Pan Y, Freundlich T, Weissman T, Schoppik D, Wang X, Zimmerman S, et al. Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish. Development. 2013;140:2835-46 pubmed publisher
    ..Among vertebrates, zebrafish is uniquely suited for in vivo imaging owing to its small size and optical translucency...
  60. Akiyama R, Masuda M, Tsuge S, Bessho Y, Matsui T. An anterior limit of FGF/Erk signal activity marks the earliest future somite boundary in zebrafish. Development. 2014;141:1104-9 pubmed publisher
    ..During somite segmentation in zebrafish, mesp-b determines a future somite boundary at position B-2 within the PSM...
  61. Nichols J, Pan L, Moens C, Kimmel C. barx1 represses joints and promotes cartilage in the craniofacial skeleton. Development. 2013;140:2765-75 pubmed publisher
    ..Genetic manipulation experiments in zebrafish demonstrate that functional loss, or gain, of the homeobox-containing gene barx1 produces gain, or loss, of ..
  62. Duval M, Chung H, Lehmann O, Allison W. Longitudinal fluorescent observation of retinal degeneration and regeneration in zebrafish using fundus lens imaging. Mol Vis. 2013;19:1082-95 pubmed
    ..To address this challenge, we used a custom fundus lens and zebrafish transgenic lines with cell-specific fluorescent reporters to document the state of individual retinal neurons in ..
  63. Armstrong G, Drapeau P. Loss and gain of FUS function impair neuromuscular synaptic transmission in a genetic model of ALS. Hum Mol Genet. 2013;22:4282-92 pubmed publisher
    ..defect, we expressed the wild-type human gene (wtFUS) or the ALS-associated mutation R521H (mutFUS) gene in zebrafish larvae and characterized their motor (swimming) activity and function of their neuromuscular junctions (NMJs)...
  64. Alunni A, Krecsmarik M, Bosco A, Galant S, Pan L, Moens C, et al. Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium. Development. 2013;140:3335-47 pubmed publisher
    ..We have previously shown that Notch signaling limits neural stem cell (NSC) proliferation in the adult zebrafish pallium...
  65. Mehta T, Ravi V, Yamasaki S, Lee A, Lian M, Tay B, et al. Evidence for at least six Hox clusters in the Japanese lamprey (Lethenteron japonicum). Proc Natl Acad Sci U S A. 2013;110:16044-9 pubmed publisher
    ..Transgenic zebrafish assay indicated the potential of CNEs to function as enhancers...
  66. Gebriel M, Prabhudesai S, Uleberg K, Larssen E, Piston D, Bjørnstad A, et al. Zebrafish brain proteomics reveals central proteins involved in neurodegeneration. J Neurosci Res. 2014;92:104-15 pubmed publisher
    ..Here we provide a map of the zebrafish brain proteome by using two-dimensional gel electrophoresis (2DE), followed by the identification of 95 brain ..
  67. Daya A, Vatine G, Becker Cohen M, Tal Goldberg T, Friedmann A, Gothilf Y, et al. Gne depletion during zebrafish development impairs skeletal muscle structure and function. Hum Mol Genet. 2014;23:3349-61 pubmed publisher
    ..fluorescent transgenic fish generation, we have characterized the spatiotemporal expression pattern of the zebrafish gne gene and have shown that it is highly conserved compared with the human ortholog...
  68. Ota S, Hisano Y, Ikawa Y, Kawahara A. Multiple genome modifications by the CRISPR/Cas9 system in zebrafish. Genes Cells. 2014;19:555-64 pubmed publisher
    ..Here, we demonstrate multiple genome modifications mediated by CRISPR/Cas9 in zebrafish (Danio rerio)...
  69. Miyake A, Itoh N. Fgf22 regulated by Fgf3/Fgf8 signaling is required for zebrafish midbrain development. Biol Open. 2013;2:515-24 pubmed publisher
    ..Here, we identified zebrafish fgf22 predominantly expressed in the posterior midbrain and anterior midbrain-hindbrain boundary (MHB) primordia ..
  70. Gupta V, Gemberling M, Karra R, Rosenfeld G, Evans T, Poss K. An injury-responsive gata4 program shapes the zebrafish cardiac ventricle. Curr Biol. 2013;23:1221-7 pubmed publisher
    ..During zebrafish heart regeneration, cardiomyocytes in the cortical layer of the ventricle induce the transcription factor gene ..
  71. Weber A, Hochmann S, Cimalla P, Gärtner M, Kuscha V, Hans S, et al. Characterization of light lesion paradigms and optical coherence tomography as tools to study adult retina regeneration in zebrafish. PLoS ONE. 2013;8:e80483 pubmed publisher
    ..lesions are a powerful tool to study the amazing ability of photoreceptors to regenerate in the adult zebrafish retina...
  72. Nagashima M, Barthel L, Raymond P. A self-renewing division of zebrafish Müller glial cells generates neuronal progenitors that require N-cadherin to regenerate retinal neurons. Development. 2013;140:4510-21 pubmed publisher
    Müller glia function as retinal stem cells in adult zebrafish. In response to loss of retinal neurons, Müller glia partially dedifferentiate, re-express neuroepithelial markers and re-enter the cell cycle...
  73. Knox B, Deng Q, Rood M, Eickhoff J, Keller N, Huttenlocher A. Distinct innate immune phagocyte responses to Aspergillus fumigatus conidia and hyphae in zebrafish larvae. Eukaryot Cell. 2014;13:1266-77 pubmed publisher
    ..fumigatus in an intact host and their contributions to host survival remain unclear. Here, we describe a larval zebrafish A. fumigatus infection model amenable to real-time imaging of host-fungal interactions in live animals...
  74. Viringipurampeer I, Shan X, Gregory Evans K, Zhang J, Mohammadi Z, Gregory Evans C. Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish. Cell Death Differ. 2014;21:665-75 pubmed publisher
    ..In pde6c(w59) mutant zebrafish, cone photoreceptors expressed high levels of receptor-interacting protein kinase 1 (RIP1) and receptor-..
  75. Zigman M, Laumann Lipp N, Titus T, Postlethwait J, Moens C. Hoxb1b controls oriented cell division, cell shape and microtubule dynamics in neural tube morphogenesis. Development. 2014;141:639-49 pubmed publisher
    ..We unveil a non-classical role for the zebrafish hoxb1b gene, which shares ancestral functions with mammalian Hoxa1, in controlling progenitor cell shape and ..
  76. Elsaeidi F, Bemben M, Zhao X, Goldman D. Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. J Neurosci. 2014;34:2632-44 pubmed publisher
    ..response observed in animals that exhibit an intrinsic capacity for optic nerve regeneration, such as zebrafish, remains unknown...
  77. Woods I, Schoppik D, Shi V, Zimmerman S, Coleman H, Greenwood J, et al. Neuropeptidergic signaling partitions arousal behaviors in zebrafish. J Neurosci. 2014;34:3142-60 pubmed publisher
    ..To overcome these limitations, we systematically dissected the neuropeptidergic modulation of arousal in larval zebrafish. We quantified spontaneous locomotor activity and responsiveness to sensory stimuli after genetically induced ..
  78. Edlund R, Ohyama T, Kantarci H, Riley B, Groves A. Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol. 2014;390:1-13 pubmed publisher
    ..b>Zebrafish foxi1 is also expressed in branchial arch ectoderm and endoderm, and morpholino knock-down of foxi1 also causes ..
  79. Jao L, Wente S, Chen W. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci U S A. 2013;110:13904-9 pubmed publisher
    A simple and robust method for targeted mutagenesis in zebrafish has long been sought. Previous methods generate monoallelic mutations in the germ line of F0 animals, usually delaying homozygosity for the mutation to the F2 generation...
  80. Peyric E, Moore H, Whitmore D. Circadian clock regulation of the cell cycle in the zebrafish intestine. PLoS ONE. 2013;8:e73209 pubmed publisher
    ..this study was to explore circadian clock regulation of cell proliferation and cell cycle gene expression in the zebrafish intestine...
  81. Fischer R, Fontinha B, Kirchmaier S, Steger J, Bloch S, Inoue D, et al. Co-expression of VAL- and TMT-opsins uncovers ancient photosensory interneurons and motorneurons in the vertebrate brain. PLoS Biol. 2013;11:e1001585 pubmed publisher
    ..We investigated two groups of nonvisual photopigments, VAL- and TMT-Opsins, in zebrafish and medaka fish; two teleost species from distinct habitats separated by over 300 million years of evolution...
  82. Boltaña S, Rey S, Roher N, Vargas R, Huerta M, Huntingford F, et al. Behavioural fever is a synergic signal amplifying the innate immune response. Proc Biol Sci. 2013;280:20131381 pubmed publisher
    ..Here, we show that zebrafish display behavioural fever that acts to promote extensive and highly specific temperature-dependent changes in ..
  83. Narla A, Payne E, Abayasekara N, Hurst S, Raiser D, Look A, et al. L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way. Br J Haematol. 2014;167:524-528 pubmed publisher
    ..To determine if the L-Leucine effect was Tp53-dependent, we used antisense MOs to rps19 and rps14 in zebrafish; expression of tp53 and its downstream target cdkn1a remained elevated following L-leucine treatment...
  84. Moro E, Vettori A, Porazzi P, Schiavone M, Rampazzo E, Casari A, et al. Generation and application of signaling pathway reporter lines in zebrafish. Mol Genet Genomics. 2013;288:231-42 pubmed publisher
    ..The transparent zebrafish embryo is one of the living models in which, after germline transformation with reporter protein-coding genes, ..
  85. Ren G, Li S, Zhong H, Lin S. Zebrafish tyrosine hydroxylase 2 gene encodes tryptophan hydroxylase. J Biol Chem. 2013;288:22451-9 pubmed publisher
    ..To facilitate the understanding of the underling mechanism of PD, several zebrafish PD models have been generated to recapitulate the characteristics of dopaminergic (DA) neuron loss...
  86. Loh S, Teh C, Müller J, Guccione E, Hong W, Korzh V. Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line. Sci Rep. 2014;4:4289 pubmed publisher
    ..The zebrafish Yap1 acts during neural differentiation, but its function is not fully understood...
  87. Jiang L, Zhang J, Wang J, Wang L, Zhang L, Li G, et al. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell. 2013;153:773-84 pubmed publisher
    ..We generated nine single-base resolution DNA methylomes, including zebrafish gametes and early embryos. The oocyte methylome is significantly hypomethylated compared to sperm...
  88. Provost E, Weier C, Leach S. Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Zebrafish. 2013;10:161-9 pubmed publisher
    ..We have identified a common expression pattern for rpl genes in developing zebrafish larvae...
  89. Corallo D, Schiavinato A, Trapani V, Moro E, Argenton F, Bonaldo P. Emilin3 is required for notochord sheath integrity and interacts with Scube2 to regulate notochord-derived Hedgehog signals. Development. 2013;140:4594-601 pubmed publisher
    ..work, we have identified the extracellular matrix glycoprotein Emilin3 as a novel essential component of the zebrafish notochord sheath. The development of the notochord sheath is impaired in Emilin3 knockdown embryos...
  90. Ye Z, Zhang C, Tu T, Sun M, Liu D, Lu D, et al. Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. Nat Commun. 2013;4:2803 pubmed publisher
    ..Here we report that Wnt5a uses CD146 as a receptor to regulate cell migration and zebrafish embryonic convergent extension...
  91. van Impel A, Zhao Z, Hermkens D, Roukens M, Fischer J, Peterson Maduro J, et al. Divergence of zebrafish and mouse lymphatic cell fate specification pathways. Development. 2014;141:1228-38 pubmed publisher
    ..Here, we re-examine the role of Prox1a in zebrafish lymphangiogenesis...
  92. Bonetti M, Paardekooper Overman J, Tessadori F, Noël E, Bakkers J, den Hertog J. Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish. Development. 2014;141:1961-70 pubmed publisher
    ..Here, we have expressed the most common NS and LS Shp2-variants in zebrafish embryos to investigate their role in cardiac development in vivo...