medaka

Summary

Alias: Japanese medaka, Japanese rice fish, Oryzias latipes, Oryzias latipes (Temminck & Schlegel, 1846)

Top Publications

  1. Au D, Mok H, Elmore L, Holt S. Japanese medaka: a new vertebrate model for studying telomere and telomerase biology. Comp Biochem Physiol C Toxicol Pharmacol. 2009;149:161-7 pubmed publisher
    ..and protein information among vertebrate TERTs (TElomerase Reverse Transcriptase), the Japanese medaka Oryzias latipes shares the highest similarity to that of the human than the other small size fish species studied (including ..
  2. Li J, Iwanami N, Hoa V, Furutani Seiki M, Takahama Y. Noninvasive intravital imaging of thymocyte dynamics in medaka. J Immunol. 2007;179:1605-15 pubmed
    ..To overcome these problems, medaka is useful because of transparency and ex-uterine development...
  3. Zhou L, Wang D, Kobayashi T, Yano A, Paul Prasanth B, Suzuki A, et al. A novel type of P450c17 lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney. Endocrinology. 2007;148:4282-91 pubmed publisher
    ..We cloned P450c17-II from tilapia and medaka, and comparison with the conventional P450c17-I revealed that they differ in gene structure and enzymatic activity...
  4. Ogiwara K, Shinohara M, Takahashi T. Expression of proprotein convertase 2 mRNA in the ovarian follicles of the medaka, Oryzias latipes. Gene. 2004;337:79-89 pubmed
    ..The clone, which was isolated from the ovary of the medaka, Oryzias latipes, by a combination of RT-PCR cloning and 5'- and 3'-rapid amplification of cDNA ends, codes for a protein of ..
  5. Brunner B, Hornung U, Shan Z, Nanda I, Kondo M, Zend Ajusch E, et al. Genomic organization and expression of the doublesex-related gene cluster in vertebrates and detection of putative regulatory regions for DMRT1. Genomics. 2001;77:8-17 pubmed publisher
    ..Although expression analysis and gene linkage mapping in medaka exclude a function for any of the three genes in the primary step of male sex determination, comparison of F...
  6. Matsuda M, Nagahama Y, Shinomiya A, Sato T, Matsuda C, Kobayashi T, et al. DMY is a Y-specific DM-domain gene required for male development in the medaka fish. Nature. 2002;417:559-63 pubmed
    ..Here, we used recombinant breakpoint analysis to restrict the sex-determining region in medaka fish (Oryzias latipes) to a 530-kilobase (kb) stretch of the Y chromosome...
  7. Shibata Y, Paul Prasanth B, Suzuki A, Usami T, Nakamoto M, Matsuda M, et al. Expression of gonadal soma derived factor (GSDF) is spatially and temporally correlated with early testicular differentiation in medaka. Gene Expr Patterns. 2010;10:283-9 pubmed publisher
    In the teleost fish, medaka (Oryzias latipes), the sex is genetically determined at the time of fertilization. The males are heterogametic with XY chromosome composition, while females are of XX chromosome composition...
  8. Nakasone K, Nagahama Y, Okubo K. hebp3, a novel member of the heme-binding protein gene family, is expressed in the medaka meninges with higher abundance in females due to a direct stimulating action of ovarian estrogens. Endocrinology. 2013;154:920-30 pubmed publisher
    ..in the teleost brain, we screened for genes differentially expressed between sexes in the brain of medaka (Oryzias latipes)...
  9. Okubo K, Takeuchi A, Chaube R, Paul Prasanth B, Kanda S, Oka Y, et al. Sex differences in aromatase gene expression in the medaka brain. J Neuroendocrinol. 2011;23:412-23 pubmed publisher
    ..differentiation of the teleost brain, we searched for genes differentially expressed between both sexes in the medaka brain...

More Information

Publications122 found, 100 shown here

  1. Kawabata Y, Hiraki T, Takeuchi A, Okubo K. Sex differences in the expression of vasotocin/isotocin, gonadotropin-releasing hormone, and tyrosine and tryptophan hydroxylase family genes in the medaka brain. Neuroscience. 2012;218:65-77 pubmed publisher
    ..the present study, we therefore systematically evaluated sex differences in their expression in the medaka (Oryzias latipes) brain...
  2. Kuroda N, Naruse K, Shima A, Nonaka M, Sasaki M. Molecular cloning and linkage analysis of complement C3 and C4 genes of the Japanese medaka fish. Immunogenetics. 2000;51:117-28 pubmed
    ..genes, termed Orla C3-1 and Orla C3-2, and one C4 gene, termed Orla C4, of a teleost, Japanese medaka fish (Oryzias latipes), by analyzing cDNA clones isolated from a liver library constructed using the inbred AA2 strain...
  3. Kondo S, Kuwahara Y, Kondo M, Naruse K, Mitani H, Wakamatsu Y, et al. The medaka rs-3 locus required for scale development encodes ectodysplasin-A receptor. Curr Biol. 2001;11:1202-6 pubmed
    ..A mutation at the rs-3 locus of medaka (Oryzias latipes) leads to almost complete loss of scales...
  4. Kasahara M, Naruse K, Sasaki S, Nakatani Y, Qu W, Ahsan B, et al. The medaka draft genome and insights into vertebrate genome evolution. Nature. 2007;447:714-9 pubmed
    ..Here we report a high-quality draft genome sequence of a small egg-laying freshwater teleost, medaka (Oryzias latipes)...
  5. Kurokawa H, Saito D, Nakamura S, Katoh Fukui Y, Ohta K, Baba T, et al. Germ cells are essential for sexual dimorphism in the medaka gonad. Proc Natl Acad Sci U S A. 2007;104:16958-63 pubmed
    To further elucidate the roles of germ cells in the sex differentiation of gonads, we have used the medaka, a teleost fish, to generate mutants that lack germ cells from the onset of gonadogenesis by the morpholino-mediated knockdown of ..
  6. Liu L, Hong N, Xu H, Li M, Yan Y, Purwanti Y, et al. Medaka dead end encodes a cytoplasmic protein and identifies embryonic and adult germ cells. Gene Expr Patterns. 2009;9:541-8 pubmed publisher
    ..Here we report the cloning and expression pattern of Odnd, the medakafish (Oryzias latipes) dnd gene...
  7. Yasutake J, Inohaya K, Kudo A. Twist functions in vertebral column formation in medaka, Oryzias latipes. Mech Dev. 2004;121:883-94 pubmed
    b>Medaka twist, a basic helix-loop-helix (bHLH) transcription factor, is expressed in the sclerotome during embryogenesis...
  8. Zhang X, Hecker M, Park J, Tompsett A, Newsted J, Nakayama K, et al. Real-time PCR array to study effects of chemicals on the Hypothalamic-Pituitary-Gonadal axis of the Japanese medaka. Aquat Toxicol. 2008;88:173-82 pubmed publisher
    ..along the hypothalamic-pituitary-gonadal (HPG) axis of the small, oviparous fish, the Japanese medaka (Oryzias latipes)...
  9. Li M, Hong N, Xu H, Yi M, Li C, Gui J, et al. Medaka vasa is required for migration but not survival of primordial germ cells. Mech Dev. 2009;126:366-81 pubmed publisher
    ..Furthermore, ectopic PGCs in vasa-depleted embryos also retained all the PGC properties examined. Taken together, medaka vasa is cell-autonomously required for PGC migration, but dispensable to PGC proliferation, motility, identity and ..
  10. Ishikawa T, Taniguchi Y, Okada T, Takeda S, Mori K. Vertebrate unfolded protein response: mammalian signaling pathways are conserved in Medaka fish. Cell Struct Funct. 2011;36:247-59 pubmed
    ..Here, we examined medaka fish, Oryzias latipes, as a vertebrate model organism, and found that the medaka genome encodes five UPR transducers...
  11. Takagi S, Sasado T, Tamiya G, Ozato K, Wakamatsu Y, Takeshita A, et al. An efficient expression vector for transgenic medaka construction. Mol Mar Biol Biotechnol. 1994;3:192-9 pubmed
    The transparency and external fertilization of the eggs of medaka (Oryzias latipes) make them ideally suitable for investigating molecular interactions that occur during vertebrate development...
  12. Krause M, Rhodes L, Van Beneden R. Cloning of the p53 tumor suppressor gene from the Japanese medaka (Oryzias latipes) and evaluation of mutational hotspots in MNNG-exposed fish. Gene. 1997;189:101-6 pubmed
    A full-length cDNA clone of the medaka (Oryzias latipes) p53 tumor suppressor gene was isolated from a cDNA library from adult liver tissue, sequenced and characterized...
  13. Loosli F, Winkler S, Burgtorf C, Wurmbach E, Ansorge W, Henrich T, et al. Medaka eyeless is the key factor linking retinal determination and eye growth. Development. 2001;128:4035-44 pubmed
    The complete absence of eyes in the medaka fish mutation eyeless is the result of defective optic vesicle evagination...
  14. Nanda I, Kondo M, Hornung U, Asakawa S, Winkler C, Shimizu A, et al. A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes. Proc Natl Acad Sci U S A. 2002;99:11778-83 pubmed
    ..We have found that in the fish medaka the Y chromosome-specific region spans only about 280 kb...
  15. Kuhl A, Manning S, Brouwer M. Brain aromatase in Japanese medaka (Oryzias latipes): Molecular characterization and role in xenoestrogen-induced sex reversal. J Steroid Biochem Mol Biol. 2005;96:67-77 pubmed publisher
    ..The objective of this study was two-fold: clone and sequence the coding and promoter region of brain aromatase in medaka, and determine the effects of exposure to an environmental estrogen (o,p-DDT) on sex determination and brain ..
  16. Mochizuki E, Fukuta K, Tada T, Harada T, Watanabe N, Matsuo S, et al. Fish mesonephric model of polycystic kidney disease in medaka (Oryzias latipes) pc mutant. Kidney Int. 2005;68:23-34 pubmed
    ..Here, we report a medaka (Oryzias latipes) mutant that develops numerous cysts in the kidney in adulthood fish in an autosomal-recessive manner as a ..
  17. Okubo K, Sakai F, Lau E, Yoshizaki G, Takeuchi Y, Naruse K, et al. Forebrain gonadotropin-releasing hormone neuronal development: insights from transgenic medaka and the relevance to X-linked Kallmann syndrome. Endocrinology. 2006;147:1076-84 pubmed
    ..In the present study, we generated transgenic medaka that expressed green fluorescent protein under the control of the gnrh1 and gnrh3 promoters for analyzing ..
  18. Xu H, Li M, Gui J, Hong Y. Cloning and expression of medaka dazl during embryogenesis and gametogenesis. Gene Expr Patterns. 2007;7:332-8 pubmed
    ..Here, we report the cloning and expression of the medakafish (Oryzias latipes) dazl gene (odazl)...
  19. Kawaguchi M, Yasumasu S, Hiroi J, Naruse K, Inoue M, Iuchi I. Evolution of teleostean hatching enzyme genes and their paralogous genes. Dev Genes Evol. 2006;216:769-84 pubmed publisher
    ..Genes for such six-cysteine-containing astacin proteases (C6AST) were searched out in the medaka genome database. Five genes for MC6AST1 to 5 were found in addition to embryo-specific hatching enzyme genes...
  20. Fukamachi S, Kinoshita M, Tsujimura T, Shimada A, Oda S, Shima A, et al. Rescue from oculocutaneous albinism type 4 using medaka slc45a2 cDNA driven by its own promoter. Genetics. 2008;178:761-9 pubmed publisher
    ..However, there is no empirical evidence for this gene-phenotype relationship. There is a unique OCA4 mutant in medaka (b) that exhibits albinism only in the skin, but the mechanism underlying this phenotype is also unknown...
  21. Pfennig F, Kind B, Zieschang F, Busch M, Gutzeit H. Tert expression and telomerase activity in gonads and somatic cells of the Japanese medaka (Oryzias latipes). Dev Growth Differ. 2008;50:131-41 pubmed publisher
    A telomerase reverse transcriptase (Tert) encoding gene was cloned from the testis of the teleost fish Oryzias latipes. The expression pattern of Japanese medaka tert (Ola_tert) was analyzed by reverse transcription-polymerase chain ..
  22. Omran H, Kobayashi D, Olbrich H, Tsukahara T, Loges N, Hagiwara H, et al. Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins. Nature. 2008;456:611-6 pubmed publisher
    ..This gene was first identified in a medaka mutant, and found to be mutated in primary ciliary dyskinesia patients from two affected families as well as in ..
  23. Sánchez Sánchez A, Camp E, Garcia Espana A, Leal Tassias A, Mullor J. Medaka Oct4 is expressed during early embryo development, and in primordial germ cells and adult gonads. Dev Dyn. 2010;239:672-9 pubmed publisher
    ..We have characterized the expression pattern of medaka (Oryzias latipes) Ol-Oct4 during embryonic development and in the adult gonads...
  24. Murata K, Sasaki T, Yasumasu S, Iuchi I, Enami J, Yasumasu I, et al. Cloning of cDNAs for the precursor protein of a low-molecular-weight subunit of the inner layer of the egg envelope (chorion) of the fish Oryzias latipes. Dev Biol. 1995;167:9-17 pubmed
    cDNA clones for L-SF, the precursor of a low-molecular-weight subunit (ZI-3) of the inner layer of the Oryzias latipes egg envelope were isolated from Lambda ZAP cDNA libraries constructed from the poly(A)+ RNA of the liver of spawning ..
  25. Kuroda N, Wada H, Naruse K, Simada A, Shima A, Sasaki M, et al. Molecular cloning and linkage analysis of the Japanese medaka fish complement Bf/C2 gene. Immunogenetics. 1996;44:459-67 pubmed
    ..linkage between the Bf/C2 gene and the MHC was established, we amplified the Bf/C2 sequences in teleost, the Japanese medaka (Oryzias latipes), by reverse transcription - polymerase chain reaction with primers corresponding to the ..
  26. Murata K, Sugiyama H, Yasumasu S, Iuchi I, Yasumasu I, Yamagami K. Cloning of cDNA and estrogen-induced hepatic gene expression for choriogenin H, a precursor protein of the fish egg envelope (chorion). Proc Natl Acad Sci U S A. 1997;94:2050-5 pubmed
    ..or H-SF), a precursor protein of the inner layer subunits of egg envelope (chorion) of the teleost fish, Oryzias latipes, was cloned and analyzed...
  27. Sugiyama H, Yasumasu S, Murata K, Iuchi I, Yamagami K. The third egg envelope subunit in fish: cDNA cloning and analysis, and gene expression. Dev Growth Differ. 1998;40:35-45 pubmed
    The inner layer of the egg envelope of a teleost fish, the medaka, Oryzias latipes, consists of two major subunit groups, ZI-1,2 and ZI-3...
  28. Tanaka M, Kinoshita M, Kobayashi D, Nagahama Y. Establishment of medaka (Oryzias latipes) transgenic lines with the expression of green fluorescent protein fluorescence exclusively in germ cells: a useful model to monitor germ cells in a live vertebrate. Proc Natl Acad Sci U S A. 2001;98:2544-9 pubmed
    We have generated transgenic medaka (teleost, Oryzias latipes), which allow us to monitor germ cells by green fluorescent protein (GFP) fluorescence in live specimens...
  29. Fukamachi S, Shimada A, Shima A. Mutations in the gene encoding B, a novel transporter protein, reduce melanin content in medaka. Nat Genet. 2001;28:381-5 pubmed
    ..In contrast, the medaka (a small, freshwater teleost) is a suitable model of the lower vertebrates because it has all kinds of ..
  30. Dasmahapatra A, Wang X, Haasch M. Expression of Adh8 mRNA is developmentally regulated in Japanese medaka (Oryzias latipes). Comp Biochem Physiol B Biochem Mol Biol. 2005;140:657-64 pubmed publisher
    We cloned two full-length alcohol dehydrogenase (ADH) cDNAs from the liver tissue of adult Japanese medaka (Oryzias latipes). The coding regions spanned 1134 and 1137 nucleotides (nt) and the deduced amino acid sequences shared 63...
  31. Matsumoto Y, Fukamachi S, Mitani H, Kawamura S. Functional characterization of visual opsin repertoire in Medaka (Oryzias latipes). Gene. 2006;371:268-78 pubmed
    ..Medaka (Oryzias latipes) is a fish species phylogenetically distant from zebrafish and has served as an important vertebrate model ..
  32. Ogoshi M, Inoue K, Naruse K, Takei Y. Evolutionary history of the calcitonin gene-related peptide family in vertebrates revealed by comparative genomic analyses. Peptides. 2006;27:3154-64 pubmed
    ..Linkage mapping and synteny analyses of the CGRP family genes in medaka, Oryzias latipes, revealed that AM1/CGRP, AM2/amylin, and AM5 genes were located on respective proto-chromosomes before the ..
  33. Taniguchi Y, Takeda S, Furutani Seiki M, Kamei Y, Todo T, Sasado T, et al. Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biol. 2006;7:R116 pubmed
    We have established a reverse genetics approach for the routine generation of medaka (Oryzias latipes) gene knockouts...
  34. Yokoi H, Shimada A, Carl M, Takashima S, Kobayashi D, Narita T, et al. Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships. Dev Biol. 2007;304:326-37 pubmed
    Medaka (Oryzias latipes) is a small freshwater teleost that provides an excellent developmental genetic model complementary to zebrafish...
  35. Kanda S, Akazome Y, Matsunaga T, Yamamoto N, Yamada S, Tsukamura H, et al. Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka (oryzias latipes). Endocrinology. 2008;149:2467-76 pubmed publisher
    ..We used medaka for the initial identification of the KiSS-1 gene and the anatomical distribution of KiSS-1 mRNA expressing ..
  36. Kitahashi T, Ogawa S, Parhar I. Cloning and expression of kiss2 in the zebrafish and medaka. Endocrinology. 2009;150:821-31 pubmed publisher
    ..In the present study, we cloned a novel kisspeptin gene (kiss2) in the zebrafish Danio rerio and the medaka Oryzias latipes, which encodes a sequence of 125 and 115 amino acids, respectively, and its core sequence (FNLNPFGLRF, F-F ..
  37. Nakamoto M, Fukasawa M, Orii S, Shimamori K, Maeda T, Suzuki A, et al. Cloning and expression of medaka cholesterol side chain cleavage cytochrome P450 during gonadal development. Dev Growth Differ. 2010;52:385-95 pubmed publisher
    ..cells and the function of sex steroids during gonadal differentiation in the teleost fish, medaka (Oryzias latipes), we isolated the full length cDNA of medaka P450scc and analyzed the expression pattern of P450scc mRNA ..
  38. Indrieri A, van Rahden V, Tiranti V, Morleo M, Iaconis D, Tammaro R, et al. Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease. Am J Hum Genet. 2012;91:942-9 pubmed publisher
    ..Downregulation of the COX7B ortholog (cox7B) in medaka (Oryzias latipes) resulted in microcephaly and microphthalmia that recapitulated the MLS phenotype and demonstrated an ..
  39. Herder C, Swiercz J, Müller C, Peravali R, Quiring R, Offermanns S, et al. ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation. Development. 2013;140:2787-97 pubmed publisher
    ..of the guanine nucleotide exchange factor ArhGEF18 affect apicobasal polarity of the retinal neuroepithelium in medaka fish...
  40. Chen S, Hong Y, Scherer S, Schartl M. Lack of ultraviolet-light inducibility of the medakafish (Oryzias latipes) tumor suppressor gene p53. Gene. 2001;264:197-203 pubmed
    ..For analyzing the function of p53 in lower vertebrates, the gene was cloned from the medakafish (Oryzias latipes). Despite some differences in the genomic organization, the fish p53 amino acid sequence is highly conserved...
  41. Kurokawa T, Murashita K. Genomic characterization of multiple leptin genes and a leptin receptor gene in the Japanese medaka, Oryzias latipes. Gen Comp Endocrinol. 2009;161:229-37 pubmed publisher
    We comprehensively surveyed leptin (LEP) and leptin receptor (LEPR) genes in medaka, Oryzias latipes and identified two LEP (mLEP-A and mLEP-B) genes and one LEPR (mLEPR) gene...
  42. Xu H, Li Z, Li M, Wang L, Hong Y. Boule is present in fish and bisexually expressed in adult and embryonic germ cells of medaka. PLoS ONE. 2009;4:e6097 pubmed publisher
    ..We show that boule and dazl coexist in medaka and stickleback...
  43. Namikawa Yamada C, Naruse K, Wada H, Shima A, Kuroda N, Nonaka M, et al. Genetic linkage between the LMP2 and LMP7 genes in the medaka fish, a teleost. Immunogenetics. 1997;46:431-3 pubmed
  44. Inoue K, Sakamoto T, Yuge S, Iwatani H, Yamagami S, Tsutsumi M, et al. Structural and functional evolution of three cardiac natriuretic peptides. Mol Biol Evol. 2005;22:2428-34 pubmed
    ..The ANP gene was also undetectable in the medaka. Thus, only the BNP gene is universal in species examined in the present study...
  45. Fujimori K, Kawasaki T, Deguchi T, Yuba S. Characterization of a nervous system-specific promoter for growth-associated protein 43 gene in Medaka (Oryzias latipes). Brain Res. 2008;1245:1-15 pubmed publisher
    ..We identified a GAP-43 homolog in Medaka (Oryzias latipes), and analyzed its expression during various stages of development...
  46. Konno N, Kurosawa M, Kaiya H, Miyazato M, Matsuda K, Uchiyama M. Molecular cloning and characterization of V2-type receptor in two ray-finned fish, gray bichir, Polypterus senegalus and medaka, Oryzias latipes. Peptides. 2010;31:1273-9 pubmed publisher
    ..In the present study, we successfully cloned V2Rs from two ray-finned fish, gray bichir and medaka. Phylogenetic analysis showed that the cloned receptors belong to the V2R group of lobe-finned fish and tetrapods...
  47. Nagai Y, Asaoka Y, Namae M, Saito K, Momose H, Mitani H, et al. The LIM protein Ajuba is required for ciliogenesis and left-right axis determination in medaka. Biochem Biophys Res Commun. 2010;396:887-93 pubmed publisher
    ..In this study, we isolated the medaka homolog of Ajuba and showed that Ajuba localizes to basal bodies of cilia in growth-arrested cells...
  48. Obata S, Yuasa E, Seki D, Kitano T, Saitoh H. Molecular cloning and bacterial expression of the catalytic domain of the SENP1 gene of Oryzias latipes. Biosci Biotechnol Biochem. 2013;77:1788-91 pubmed
    In this study, we cloned the catalytic domain of the Oryzias latipes sentrin/SUMO-specific protease 1 (OlSENP1-CD) gene and produced the recombinant OlSENP1-CD protein in Escherichia coli...
  49. Shiozaki K, Ryuzono S, Matsushita N, Ikeda A, Takeshita K, Chigwechokha P, et al. Molecular cloning and biochemical characterization of medaka (Oryzias latipes) lysosomal neu4 sialidase. Fish Physiol Biochem. 2014;40:1461-72 pubmed publisher
    ..Here, to investigate the significance of fish neu4 sialidase, neu4 gene was cloned from medaka brain mRNA and identified...
  50. Alonzo F, Hertel Aas T, Real A, Lance E, Garcia Sanchez L, Bradshaw C, et al. Population modelling to compare chronic external radiotoxicity between individual and population endpoints in four taxonomic groups. J Environ Radioact. 2016;152:46-59 pubmed publisher
    ..with values ranging from 26 μGy h(-1) in the mouse Mus musculus to 38,000 μGy h(-1) in the fish Oryzias latipes. For several species, EDR10 for population endpoints were lower than the lowest EDR10 for individual ..
  51. Chen Q, Lu X, Li M, Chen J. Molecular cloning, pathologically-correlated expression and functional characterization of the colonystimulating factor 1 receptor (CSF-1R) gene from a teleost, Plecoglossus altivelis. Dongwuxue Yanjiu. 2016;37:96-102 pubmed publisher
    ..and phylogenetic tree analysis showed that PaCSF-1R was most closely related to that of Japanese ricefish (Oryzias latipes)...
  52. Inoue Y, Saga T, Aikawa T, Kumagai M, Shimada A, Kawaguchi Y, et al. Complete fusion of a transposon and herpesvirus created the Teratorn mobile element in medaka fish. Nat Commun. 2017;8:551 pubmed publisher
    ..Here, we report a giant (180-kb long) transposon, Teratorn, originally identified in the genome of medaka, Oryzias latipes. Teratorn belongs to the piggyBac superfamily and retains the transposition activity...
  53. Ansai S, Hosokawa H, Maegawa S, Naruse K, Washio Y, Sato K, et al. Deficiency of Serotonin in Raphe Neurons and Altered Behavioral Responses in Tryptophan Hydroxylase 2-Knockout Medaka (Oryzias latipes). Zebrafish. 2017;: pubmed
    ..Here, we established a medaka (Oryzias latipes) strain with targeted disruption of tryptophan hydroxylase 2 (tph2) gene that is involved in the 5-HT ..
  54. Shibata Y, Iwamatsu T, Oba Y, Kobayashi D, Tanaka M, Nagahama Y, et al. Identification and cDNA cloning of alveolin, an extracellular metalloproteinase, which induces chorion hardening of medaka (Oryzias latipes) eggs upon fertilization. J Biol Chem. 2000;275:8349-54 pubmed
    ..hardening is triggered by the contents of cortical alveoli that are released upon fertilization of medaka (Oryzias latipes) eggs...
  55. Mollicone R, Moore S, Bovin N, Garcia Rosasco M, Candelier J, Martinez Duncker I, et al. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). J Biol Chem. 2009;284:4723-38 pubmed publisher
  56. Anzai D, Tonoyama Y, Ikeda A, Kawasaki T, Oka S. Regulated expression of the HNK-1 carbohydrate is essential for medaka (Oryzias latipes) embryogenesis. Glycobiology. 2009;19:868-78 pubmed publisher
    ..Here, we examined the roles of the human natural killer-1 (HNK-1) carbohydrate in medaka embryogenesis...
  57. Zhao Y, Wayne N. Effects of kisspeptin1 on electrical activity of an extrahypothalamic population of gonadotropin-releasing hormone neurons in medaka (Oryzias latipes). PLoS ONE. 2012;7:e37909 pubmed publisher
    ..In medaka fish, the electrical activity of TN-GnRH3 neurons is modulated by visual cues from conspecifics, and is thought to ..
  58. Sandvik G, Hodne K, Haug T, Okubo K, Weltzien F. RFamide Peptides in Early Vertebrate Development. Front Endocrinol (Lausanne). 2014;5:203 pubmed publisher
    ..In a teleost, the Japanese medaka, knockdown of genes in the Kiss system indicates that Kiss ligands and receptors are vital for brain ..
  59. Conte I, Hadfield K, Barbato S, Carrella S, Pizzo M, Bhat R, et al. MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma. Proc Natl Acad Sci U S A. 2015;112:E3236-45 pubmed publisher
    ..In vivo injection, in medaka fish (Oryzias latipes), of the mutated miR-204 caused a phenotype consistent with that observed in the family, including ..
  60. Seemann F, Peterson D, Witten P, Guo B, Shanthanagouda A, Ye R, et al. Insight into the transgenerational effect of benzo[a]pyrene on bone formation in a teleost fish (Oryzias latipes). Comp Biochem Physiol C Toxicol Pharmacol. 2015;178:60-67 pubmed publisher
    ..Adult Oryzias latipes were exposed to 1μg/L BaP for 21days...
  61. Kikuta A, Furukawa E, Ogawa R, Suganuma N, Saitoh M, Nishimaki T, et al. Biochemical Characterization of Medaka (Oryzias latipes) Transglutaminases, OlTGK1 and OlTGK2, as Orthologues of Human Keratinocyte-Type Transglutaminase. PLoS ONE. 2015;10:e0144194 pubmed publisher
    ..Medaka (Oryzias latipes) has been used as a model fish to investigate the physiological functions of mammalian proteins...
  62. Kagawa N, Honda A, Zenno A, Omoto R, Imanaka S, Takehana Y, et al. Arginine vasotocin neuronal development and its projection in the adult brain of the medaka. Neurosci Lett. 2016;613:47-53 pubmed publisher
    ..Here, we generated a new line of transgenic medaka (Oryzias latipes), which allowed us to monitor AVT neurons by enhanced green fluorescent protein (EGFP) and demonstrate AVT ..
  63. Watanabe H, Horie Y, Takanobu H, Koshio M, Flynn K, Iguchi T, et al. Medaka extended one-generation reproduction test evaluating 4-nonylphenol. Environ Toxicol Chem. 2017;36:3254-3266 pubmed publisher
    ..Briefly, 3 generations of Japanese medaka (Oryzias latipes) are exposed to a chemical over a 20-wk period: 3 wk in the parental generation (F0), 15 wk in the first ..
  64. Zhang Z, Hu J. Development and validation of endogenous reference genes for expression profiling of medaka (Oryzias latipes) exposed to endocrine disrupting chemicals by quantitative real-time RT-PCR. Toxicol Sci. 2007;95:356-68 pubmed publisher
    ..In this study, we cloned ribosomal protein L7 (RPL-7) from medaka (Oryzias latipes), and then used Q-RT-PCR to study its transcription characteristics and those of glyceraldehyde-3-phosphate ..
  65. Inoue D, Stemmer M, Thumberger T, Ruppert T, Bärenz F, Wittbrodt J, et al. Expression of the novel maternal centrosome assembly factor Wdr8 is required for vertebrate embryonic mitoses. Nat Commun. 2017;8:14090 pubmed publisher
    ..maternally essential protein that is required for centrosome assembly during embryonic mitoses of medaka (Oryzias latipes)...
  66. Kim B, Ji K, Kho Y, Kim P, Park K, Kim K, et al. Effects of chronic exposure to cefadroxil and cefradine on Daphnia magna and Oryzias latipes. Chemosphere. 2017;185:844-851 pubmed publisher
    ..cefradine, and its underlying mechanism were investigated by chronic exposure of Daphnia magna (21 d) and Oryzias latipes (120 d)...
  67. Shiraishi E, Imazato H, Yamamoto T, Yokoi H, Abe S, Kitano T. Identification of two teleost homologs of the Drosophila sex determination factor, transformer-2 in medaka (Oryzias latipes). Mech Dev. 2004;121:991-6 pubmed
    ..We identified two teleost homologues of Tra2, which we named Tra2a and Tra2b, in medaka (Oryzias latipes)...
  68. Robinson J, Staveley J, Constantine L. Reproductive effects on freshwater fish exposed to 17α-trenbolone and 17α-estradiol. Environ Toxicol Chem. 2017;36:636-644 pubmed publisher
    ..assay was conducted with 17α-trenbolone using the fathead minnow (Pimephales promelas) and the medaka (Oryzias latipes) and with 17α-estradiol using the fathead minnow...
  69. Wagner S, Kurobe T, Hammock B, Lam C, Wu G, Vasylieva N, et al. Developmental effects of fipronil on Japanese Medaka (Oryzias latipes) embryos. Chemosphere. 2017;166:511-520 pubmed publisher
    ..Here, we evaluated toxicity of fipronil to embryos of Japanese Medaka (Oryzias latipes, Qurt strain) using a high-throughput 96-well plate toxicity test...
  70. Fujimori C, Ogiwara K, Hagiwara A, Rajapakse S, Kimura A, Takahashi T. Expression of cyclooxygenase-2 and prostaglandin receptor EP4b mRNA in the ovary of the medaka fish, Oryzias latipes: possible involvement in ovulation. Mol Cell Endocrinol. 2011;332:67-77 pubmed publisher
    In vitro ovulation of mature medaka ovarian follicles was inhibited by inhibitors of cyclooxygenase (COX) or by an antagonist of the prostaglandin E(2) receptor (EP)...
  71. To T, Witten P, Renn J, Bhattacharya D, Huysseune A, Winkler C. Rankl-induced osteoclastogenesis leads to loss of mineralization in a medaka osteoporosis model. Development. 2012;139:141-50 pubmed publisher
    ..Here, we report an osteoporotic phenotype that is induced by overexpression of Rankl in the medaka model...
  72. González Doncel M, Carbonell G, San Segundo L, Sastre S, Beltrán E, Fernández Torija C. Stage-dependent ethoxyresorufin-O-deethylase (EROD) in vivo activity in medaka (Oryzias latipes) embryos. Chemosphere. 2015;135:108-15 pubmed publisher
    Using medaka (Oryzias latipes) embryos, this study aimed to quantitatively characterize the stage-dependent in vivo ethoxyresorufin-O-deethylase (EROD) as indicator of cytochrome P4501A (CYP1A) activity...
  73. Chu S, Liao P, Chen P. Developmental exposures to an azole fungicide triadimenol at environmentally relevant concentrations cause reproductive dysfunction in females of medaka fish. Chemosphere. 2016;152:181-9 pubmed publisher
    ..In this study, we investigated developmental toxicity and endocrine disruption effects in medaka fish (Oryzias latipes) exposed at an early life stage to triadimenol...
  74. Shemer R, Eibschitz I, Cavari B. Isolation and characterization of medaka ribosomal protein S3a (fte-1) cDNA and gene. Gene. 2000;250:209-17 pubmed
    ..for the first time, the isolation of the ribosomal protein S3a cDNA and gene from a teleost - the medaka (Oryzias latipes). The cDNA sequence is 863bp long and encodes an open reading frame of 266 amino acids...
  75. Kamura K, Kobayashi D, Uehara Y, Koshida S, Iijima N, Kudo A, et al. Pkd1l1 complexes with Pkd2 on motile cilia and functions to establish the left-right axis. Development. 2011;138:1121-9 pubmed publisher
    ..In the current study, we show that the medaka left-right mutant abecobe (abc) is defective for left-right asymmetric expression of southpaw, lefty and charon, ..
  76. Premzl M, Gamulin V. Comparative genomic analysis of prion genes. BMC Genomics. 2007;8:1 pubmed publisher
    ..It is likely that the conserved genomic elements identified in this analysis represent bona fide cis-elements. However, this idea needs to be confirmed by functional assays in transgenic systems...
  77. Takamatsu N, Kurosawa G, Takahashi M, Inokuma R, Tanaka M, Kanamori A, et al. Duplicated Abd-B class genes in medaka hoxAa and hoxAb clusters exhibit differential expression patterns in pectoral fin buds. Dev Genes Evol. 2007;217:263-73 pubmed publisher
    ..We earlier completely sequenced the entire hox gene loci in medaka fish, showing a total of 46 hox genes to be encoded in seven clusters (hoxAa, Ab, Ba, Bb, Ca, Da, Db)...
  78. Satone H, Oshima Y, Shimasaki Y, Tawaratsumida T, Oba Y, Takahashi E, et al. Tributyltin-binding protein type 1 has a distinctive lipocalin-like structure and is involved in the excretion of tributyltin in Japanese flounder, Paralichthys olivaceus. Aquat Toxicol. 2008;90:292-9 pubmed publisher
    ..Western blotting analysis revealed that TBT-bp1 was present in the skin mucus. These results suggest that TBT-bp1 in Japanese flounder binds with TBT and is excreted from the body via the mucus...
  79. John L, Yoong S, Ward A. Evolution of the Ikaros gene family: implications for the origins of adaptive immunity. J Immunol. 2009;182:4792-9 pubmed publisher
    ..Instead, this study is consistent with a later emergence of adaptive immunity coincident with the appearance of the definitive lymphoid markers Ikaros, Aiolos, and Helios. ..
  80. Sinn R, Peravali R, Heermann S, Wittbrodt J. Differential responsiveness of distinct retinal domains to Atoh7. Mech Dev. 2014;133:218-29 pubmed publisher
    ..In this study we addressed the differential susceptibilities of early RPCs to Atoh7 in vivo, using medaka. Unexpectedly, we observed a largely normal development of the dorsal retina, although atoh7 was precociously ..
  81. Kl ver N, Kondo M, Herpin A, Mitani H, Schartl M. Divergent expression patterns of Sox9 duplicates in teleosts indicate a lineage specific subfunctionalization. Dev Genes Evol. 2005;215:297-305 pubmed publisher
    ..To date, only one Sox9 had been identified in medaka (Oryzias latipes). We have now isolated the second Sox9 gene...
  82. Bajoghli B, Aghaallaei N, Soroldoni D, Czerny T. The roles of Groucho/Tle in left-right asymmetry and Kupffer's vesicle organogenesis. Dev Biol. 2007;303:347-61 pubmed publisher
    ..We observed strong cardiac laterality phenotypes in medaka embryos by manipulating Groucho protein activity...
  83. Tong L, Guo L, Lv X, Li Y. Modification of polychlorinated phenols and evaluation of their toxicity, biodegradation and bioconcentration using three-dimensional quantitative structure-activity relationship models. J Mol Graph Model. 2017;71:1-12 pubmed publisher
    ..bioconcentration in fish (containing Poecilia reticulata, Oncorhynchus mykiss, Pimephales promelas and Oryzias latipes) showed that there was no significant difference between the bioconcentration factors of the four new ..
  84. Horng J, Yu L, Liu S, Chen P, Lin L. Potassium Regulation in Medaka (Oryzias latipes) Larvae Acclimated to Fresh Water: Passive Uptake and Active Secretion by the Skin Cells. Sci Rep. 2017;7:16215 pubmed publisher
    ..In this study, we investigated the mechanism of K+ regulation in medaka larvae acclimated to fresh water...
  85. Blom E, van de Vrugt H, de Vries Y, de Winter J, Arwert F, Joenje H. Multiple TPR motifs characterize the Fanconi anemia FANCG protein. DNA Repair (Amst). 2004;3:77-84 pubmed
    ..search strategy comparing the human FANCG protein sequence with its ortholog sequences in Oryzias latipes (Japanese rice fish) and Danio rerio (zebrafish) we identified at least seven tetratricopeptide repeat motifs (TPRs) covering a ..
  86. Hosono K, Sasaki T, Minoshima S, Shimizu N. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Gene. 2004;340:31-43 pubmed publisher
    ..The subcellular localization of YPEL proteins in association with centrosome or mitotic spindle suggests a novel function involved in the cell division...
  87. Fukamachi S, Yada T, Mitani H. Medaka receptors for somatolactin and growth hormone: phylogenetic paradox among fish growth hormone receptors. Genetics. 2005;171:1875-83 pubmed publisher
    ..The SL-deficient mutant of medaka (color interfere, ci) and an SL receptor (SLR) recently identified in salmon provide a fascinating field for ..
  88. Sakamaki K, Nozaki M, Kominami K, Satou Y. The evolutionary conservation of the core components necessary for the extrinsic apoptotic signaling pathway, in Medaka fish. BMC Genomics. 2007;8:141 pubmed publisher
    ..and caspase-8 that correspond to the death receptor, adaptor and initiator caspase, from the Medaka fish (Oryzias latipes)...
  89. Taneda Y, Konno S, Makino S, Morioka M, Fukuda K, Imai Y, et al. Epigenetic control of cardiomyocyte production in response to a stress during the medaka heart development. Dev Biol. 2010;340:30-40 pubmed publisher
    ..Taking advantage of longer developmental period of medaka fish, we could examine the later emerging tissue responses to the defect of ventricular beating, which occurred in ..
  90. Cui J, Shen X, Zhao H, Nagahama Y. Genome-wide analysis of Sox genes in Medaka (Oryzias latipes) and their expression pattern in embryonic development. Cytogenet Genome Res. 2011;134:283-94 pubmed publisher
    ..In this study, we identified 15 sox genes by searching for the high-mobility group domain in the medaka genome and by polymerase chain reaction using primers designed from the results obtained from homology protein ..
  91. Portela Bens S, Merlo M, Rodríguez M, Cross I, Manchado M, Kosyakova N, et al. Integrated gene mapping and synteny studies give insights into the evolution of a sex proto-chromosome in Solea senegalensis. Chromosoma. 2017;126:261-277 pubmed publisher
    ..Phylogenetic studies show the close proximity of S. senegalensis to Oryzias latipes, a species with an XX/XY system and a sex master gene...
  92. Nishimura T, Nakamura S, Tanaka M. A Structurally and Functionally Common Unit in Testes and Ovaries of Medaka (Oryzias latipes), a Teleost Fish. Sex Dev. 2016;10:159-65 pubmed publisher
    ..unit that reserves sexually indifferent or unfixed germline stem cells in both the ovaries and testes of adult medaka. During testicular development, the unit expands and gives rise to lobules where germline stem cells continuously ..