Saccoglossus kowalevskii


Alias: Saccoglossus kowalevskyi, Saccoglossus kowalesvskii

Top Publications

  1. Monti E, Bassi M, Papini N, Riboni M, Manzoni M, Venerando B, et al. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Biochem J. 2000;349:343-51 pubmed
    ..8. Immunofluorescence staining of the transfected COS7 cells demonstrated the protein's localization in the plasma membrane. ..
  2. Monti E, Bassi M, Bresciani R, Civini S, Croci G, Papini N, et al. Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. Genomics. 2004;83:445-53 pubmed
    ..Immunofluorescence staining and Western blot analysis demonstrated the association of NEU4 with the inner cell membranes. ..
  3. Giacopuzzi E, Barlati S, Preti A, Venerando B, Monti E, Borsani G, et al. Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops. BMC Biochem. 2011;12:45 pubmed publisher
    ..Giving the peculiar organization of the loop region identified in Gg NEU3, this protein can be considered of particular interest in such evolutionary studies and to get deeper insights in sialidase evolution. ..
  4. Manzoni M, Colombi P, Papini N, Rubaga L, Tiso N, Preti A, et al. Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio). Biochem J. 2007;408:395-406 pubmed publisher
    ..Overall, the redundancy of sialidases together with their expression profile and their activity exerted on gangliosides of living cells indicate the biological relevance of this class of enzymes in zebrafish...
  5. Fritzenwanker J, Uhlinger K, Gerhart J, Silva E, Lowe C. Untangling posterior growth and segmentation by analyzing mechanisms of axis elongation in hemichordates. Proc Natl Acad Sci U S A. 2019;116:8403-8408 pubmed publisher
    ..Here we investigate the developmental roles of canonical Wnt and Notch signaling in the hemichordate Saccoglossus kowalevskii and reveal that both pathways play key roles in PAE immediately following the completion of ..
  6. Uda K, Ishizuka N, Edashige Y, Kikuchi A, Radkov A, Moe L. Cloning and characterization of a novel aspartate/glutamate racemase from the acorn worm Saccoglossus kowalevskii. Comp Biochem Physiol B Biochem Mol Biol. 2019;232:87-92 pubmed publisher, we cloned and characterized two mammalian SerR homologous genes from the hemichordate acorn worm (Saccoglossus kowalevskii)...
  7. Hoffmann F, Opazo J, Hoogewijs D, Hankeln T, Ebner B, Vinogradov S, et al. Evolution of the globin gene family in deuterostomes: lineage-specific patterns of diversification and attrition. Mol Biol Evol. 2012;29:1735-45 pubmed publisher
    ..We first characterized the globin genes of the acorn worm, Saccoglossus kowalevskii, a representative of the phylum Hemichordata...
  8. Kaul Strehlow S, Stach T. A detailed description of the development of the hemichordate Saccoglossus kowalevskii using SEM, TEM, Histology and 3D-reconstructions. Front Zool. 2013;10:53 pubmed publisher
    ..In the present study, we investigated the development of all tissues in an enteropneust, Saccoglossus kowalevskii by using modern morphological techniques such as complete serial sectioning for LM and TEM, and 3D-..
  9. Jekely G. Global view of the evolution and diversity of metazoan neuropeptide signaling. Proc Natl Acad Sci U S A. 2013;110:8702-7 pubmed publisher
    ..Several pNPs were also identified from the hemichordate Saccoglossus kowalevskii and the cephalochordate Branchiostoma floridae, elucidating pNP evolution in deuterostomes...

More Information


  1. Piednoël M, Gonçalves I, Higuet D, Bonnivard E. Eukaryote DIRS1-like retrotransposons: an overview. BMC Genomics. 2011;12:621 pubmed publisher
    ..number, a few bursts of transposition are strongly suggested in certain species, such as Danio rerio and Saccoglossus kowalevskii. In this study, we report 14 new species and 8 new higher taxa that were not previously known to harbor ..
  2. Minor P, Clarke D, Andrade López J, Fritzenwanker J, Gray J, Lowe C. I-SceI Meganuclease-mediated transgenesis in the acorn worm, Saccoglossus kowalevskii. Dev Biol. 2019;445:8-15 pubmed publisher
    ..The genome of the hemichordate, Saccoglossus kowalevskii, reveals an extensive set of non-coding elements conserved across all three deuterostome phyla...
  3. Dunning Hotopp J. Grafting or pruning in the animal tree: lateral gene transfer and gene loss?. BMC Genomics. 2018;19:470 pubmed publisher
    ..LGT but was later debunked as it has a significant BLAST match to a more recently deposited genome of Saccoglossus kowalevskii, a flatworm, Metazoan, and hemichordate...
  4. Cannon J, Kocot K, Waits D, Weese D, Swalla B, Santos S, et al. Phylogenomic resolution of the hemichordate and echinoderm clade. Curr Biol. 2014;24:2827-32 pubmed publisher
    ..g., the acorn worms Saccoglossus kowalevskii and Ptychodera flava and the sea urchin Strongylocentrotus purpuratus)...
  5. Suzuki M, Tochigi M, Sakaguchi H, Aoki F, Miyamoto N. Identification of a transformer homolog in the acorn worm, Saccoglossus kowalevskii, and analysis of its activity in insect cells. Dev Genes Evol. 2015;225:161-9 pubmed publisher
    ..We have isolated a tra homolog in the acorn worm, Saccoglossus kowalevskii, which is a hemichordate belonging to the deuterostome superphylum...
  6. Robertson H. The Insect Chemoreceptor Superfamily Is Ancient in Animals. Chem Senses. 2015;40:609-14 pubmed publisher
    ..and the sea hare Aplysia californica), the sea urchin Strongylocentrotus purpuratus, and the sea acorn Saccoglossus kowalevskii. While some of these animals contain multiple divergent GRL lineages, GRLs have been lost entirely from ..
  7. Kaul Strehlow S, Urata M, Minokawa T, Stach T, Wanninger A. Neurogenesis in directly and indirectly developing enteropneusts: of nets and cords. Org Divers Evol. 2015;15:405-422 pubmed
    ..We followed morphogenesis of the nervous system in two enteropneust species, one with direct (Saccoglossus kowalevskii) and the other with indirect development (Balanoglossus misakiensis), using an antibody ..
  8. Onai T. The evolutionary origin of chordate segmentation: revisiting the enterocoel theory. Theory Biosci. 2018;137:1-16 pubmed publisher
    ..patterning between chordates (cephalochordates, vertebrates) and a direct developing hemichordate (Saccoglossus kowalevskii)...
  9. Kaul Strehlow S, Urata M, Praher D, Wanninger A. Neuronal patterning of the tubular collar cord is highly conserved among enteropneusts but dissimilar to the chordate neural tube. Sci Rep. 2017;7:7003 pubmed publisher
    ..Since the majority of data on enteropneusts stem from the harrimaniid Saccoglossus kowalevskii, putative interspecific variations remain undetected resulting in an unreliable ground pattern that ..
  10. Gonzalez P, Uhlinger K, Lowe C. The Adult Body Plan of Indirect Developing Hemichordates Develops by Adding a Hox-Patterned Trunk to an Anterior Larval Territory. Curr Biol. 2017;27:87-95 pubmed publisher
    ..the AP axis converges on a molecular architecture similar to that of the direct developing hemichordate Saccoglossus kowalevskii. These results identify a molecular correlate of a major difference in body plan between hemichordate ..
  11. Hahn Y. Molecular evolution of TEPP protein genes in metazoans. Biochem Genet. 2009;47:651-64 pubmed publisher
    ..No homolog was detected in birds, insects, nematodes, and teleost fishes despite the extensive sequence data of these species, implying that the TEPP gene might be lost in these lineages. ..
  12. Bauknecht P, Jekely G. Ancient coexistence of norepinephrine, tyramine, and octopamine signaling in bilaterians. BMC Biol. 2017;15:6 pubmed publisher
    ..These receptors represent the first examples of adrenergic receptors in protostomes. In the deuterostome Saccoglossus kowalevskii (a hemichordate), we have identified and characterized octopamine α, octopamine β, tyramine type 1, and ..
  13. Yuan Q, Sun L, Li J, An C. Elevated VEGF levels contribute to the pathogenesis of osteoarthritis. BMC Musculoskelet Disord. 2014;15:437 pubmed publisher
    ..05). Our meta-analysis provides evidence that higher VEGF expression levels strongly correlate with the pathogenesis of osteoarthritis. ..
  14. Stewart M, Stewart P, Rivera Posada J. De novo assembly of the transcriptome of Acanthaster planci testes. Mol Ecol Resour. 2015;15:953-66 pubmed publisher
    ..The identification of genes directly involved in sperm development (DEAD-box family proteins), motility, fertilization and signalling (Bindin/Speract receptor) are also discussed. ..
  15. Pezzementi L, Geiss C, King W, Lenfant N, Chatonnet A. Molecular characterization of an acetylcholinesterase from the hemichordate Saccoglossus kowalevskii. Comp Biochem Physiol B Biochem Mol Biol. 2015;181:50-8 pubmed publisher
    ..Here we present results on an AChE from a basal deuterostome, a model hemichordate, the acorn worm Saccoglossus kowalevskii. Of the eight genes coding for putative ChE-like proteins possessing Trp84, a characteristic of the ..
  16. Bera T, Hahn Y, Lee B, Pastan I. TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. Biochem Biophys Res Commun. 2003;312:1209-15 pubmed
    ..Selective expression of TEPP in testis, prostate, and in placenta and its high conservation among different species indicate that TEPP might have a role in reproductive biology. ..
  17. Bovenschulte M, Weber K. Deuterostomic actin genes and the definition of the chordates: cDNA cloning and gene organization for cephalochordates and hemichordates. J Mol Evol. 1997;45:653-60 pubmed
    ..of two actin genes from the cephalochordate Branchiostoma lanceolatum and two from the hemichordate Saccoglossus kowalevskii The Branchiostoma genes specify a muscle and a nonmuscle actin type, respectively...
  18. Friedrich M, Caravas J. New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone. J Exp Zool B Mol Dev Evol. 2011;316:387-92 pubmed publisher
    ..Taken together, these findings identify Drosophila eyg as the baptizing member of an ancient Pax gene subfamily and recommend abandoning its classification as Pax6(5a)-related gene. ..
  19. Visser W, Verhoeven Duif N, de Koning T. Identification of a human trans-3-hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes. J Biol Chem. 2012;287:21654-62 pubmed publisher
  20. Rychel A, Smith S, Shimamoto H, Swalla B. Evolution and development of the chordates: collagen and pharyngeal cartilage. Mol Biol Evol. 2006;23:541-9 pubmed publisher
    ..Our evidence suggests that the deuterostome ancestor was a benthic worm with gill slits and acellular gill cartilages...
  21. Lowe C, Terasaki M, Wu M, Freeman R, Runft L, Kwan K, et al. Dorsoventral patterning in hemichordates: insights into early chordate evolution. PLoS Biol. 2006;4:e291 pubmed publisher
    ..Finally, since hemichordates develop the mouth on the non-Bmp side, like arthropods but opposite to chordates, the mouth and Bmp-Chordin axis may have rearranged in the chordate line, one relative to the other...
  22. Gillis J, Fritzenwanker J, Lowe C. A stem-deuterostome origin of the vertebrate pharyngeal transcriptional network. Proc Biol Sci. 2012;279:237-46 pubmed publisher
    ..of transcription factor expression between the developing pharyngeal gill pores of the hemichordate Saccoglossus kowalevskii and the pharyngeal gill slit precursors (i.e. pharyngeal endodermal outpockets) of vertebrates...
  23. Darras S, Gerhart J, Terasaki M, Kirschner M, Lowe C. ?-catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate Saccoglossus kowalevskii. Development. 2011;138:959-70 pubmed publisher
    ..deuterostome evolution, we have studied the early development of the direct developing hemichordate Saccoglossus kowalevskii. We show that the zygote is polarized after fertilization along the animal-vegetal axis by cytoplasmic ..
  24. Rebscher N, Deichmann C, Sudhop S, Fritzenwanker J, Green S, Hassel M. Conserved intron positions in FGFR genes reflect the modular structure of FGFR and reveal stepwise addition of domains to an already complex ancestral FGFR. Dev Genes Evol. 2009;219:455-68 pubmed publisher
    ..We propose that the first multidomain FGFR originated in the last common ancestor of Placozoa, Cnidaria, and Bilateria. Additional domains were introduced mainly in the ancestor of triploblasts and in the Ecdysozoa...
  25. Aronowicz J, Lowe C. Hox gene expression in the hemichordate Saccoglossus kowalevskii and the evolution of deuterostome nervous systems. Integr Comp Biol. 2006;46:890-901 pubmed publisher
    ..present a description of hox gene expression during the development of the direct-developing hemichordate Saccoglossus kowalevskii. The nested ectodermal expression of these genes in a hemichordate suggest that they play a general ..
  26. Lemons D, Fritzenwanker J, Gerhart J, Lowe C, McGinnis W. Co-option of an anteroposterior head axis patterning system for proximodistal patterning of appendages in early bilaterian evolution. Dev Biol. 2010;344:358-62 pubmed publisher
    ..are expressed in similar registers in the anterior embryonic neurectoderm of Drosophila melanogaster and Saccoglossus kowalevskii (a hemichordate)...
  27. Bourlat S, Juliusdottir T, Lowe C, Freeman R, Aronowicz J, Kirschner M, et al. Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida. Nature. 2006;444:85-8 pubmed publisher
    ..As such, Xenoturbella is shown to be an independent phylum, Xenoturbellida, bringing the number of living deuterostome phyla to four...
  28. Peterson K, Lyons J, Nowak K, Takacs C, Wargo M, McPeek M. Estimating metazoan divergence times with a molecular clock. Proc Natl Acad Sci U S A. 2004;101:6536-41 pubmed publisher
    ..These results are in accord with the known fossil record and support the view that the Cambrian explosion reflects, in part, the diversification of bilaterian phyla...
  29. Giacopuzzi E, Bresciani R, Schauer R, Monti E, Borsani G. New insights on the sialidase protein family revealed by a phylogenetic analysis in metazoa. PLoS ONE. 2012;7:e44193 pubmed publisher
    ..Moreover, we further confirm findings on the catalytic residues and identified enzyme loop portions that behave as rapidly diverging regions and may be involved in the evolution of specific properties of sialidases...
  30. Zimek A, Weber K. The gene for a cytoplasmic intermediate filament (IF) protein of the hemichordate Saccoglossus kowalevskii; definition of the unique features of chordate IF proteins. Gene. 2002;288:187-93 pubmed
    ..cytoplasmic intermediate filament (IF) protein of a priapulid (Priapulus caudatus) and of a hemichordate (Saccoglossus kowalevskii) and determined the organisation of the hemichordate gene...
  31. Monti E, Preti A, Rossi E, Ballabio A, Borsani G. Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases. Genomics. 1999;57:137-43 pubmed publisher
    ..Northern blot analysis revealed expression of the NEU2 transcript only in skeletal muscle...