Amphimedon queenslandica


Alias: Amphimedon queenslandica Hooper & Van Soest, 2006, Reniera sp. JGI-2005

Top Publications

  1. Larroux C, Fahey B, Liubicich D, Hinman V, Gauthier M, Gongora M, et al. Developmental expression of transcription factor genes in a demosponge: insights into the origin of metazoan multicellularity. Evol Dev. 2006;8:150-73 pubmed
  2. Larroux C, Fahey B, Degnan S, Adamski M, Rokhsar D, Degnan B. The NK homeobox gene cluster predates the origin of Hox genes. Curr Biol. 2007;17:706-10 pubmed
    ..By using whole genome information from the demosponge Amphimedon queenslandica, we provide the first conclusive evidence that the earliest metazoans possessed multiple NK-like genes ..
  3. Jackson D, Macis L, Reitner J, Degnan B, Worheide G. Sponge paleogenomics reveals an ancient role for carbonic anhydrase in skeletogenesis. Science. 2007;316:1893-5 pubmed
  4. Adamska M, Degnan S, Green K, Adamski M, Craigie A, Larroux C, et al. Wnt and TGF-beta expression in the sponge Amphimedon queenslandica and the origin of metazoan embryonic patterning. PLoS ONE. 2007;2:e1031 pubmed publisher
    ..Using resources generated in the recent sponge Amphimedon queenslandica (Demospongiae) genome project, we have recovered genes encoding Wnt and TGF-beta signalling ligands that ..
  5. Gauthier M, Degnan B. The transcription factor NF-kappaB in the demosponge Amphimedon queenslandica: insights on the evolutionary origin of the Rel homology domain. Dev Genes Evol. 2008;218:23-32 pubmed publisher
    ..By identifying a single NF-kappaB gene in the genome of the demosponge Amphimedon queenslandica, a representative of an even earlier branching metazoan lineage, we demonstrate here that the Rel/NF-..
  6. Wells G, Tang Q, Heler R, Tompkins Macdonald G, Pritchard E, Leys S, et al. A unique alkaline pH-regulated and fatty acid-activated tandem pore domain potassium channel (K?P) from a marine sponge. J Exp Biol. 2012;215:2435-44 pubmed publisher of the two-pore domain family (K(2P), KCNK) of leak channels was cloned from the marine sponge Amphimedon queenslandica. Phylogenetic analysis indicated that AquK(2P) cannot be placed into any of the established functional ..
  7. Erpenbeck D, Voigt O, Adamski M, Adamska M, Hooper J, W rheide G, et al. Mitochondrial diversity of early-branching metazoa is revealed by the complete mt genome of a haplosclerid demosponge. Mol Biol Evol. 2007;24:19-22 pubmed publisher
    ..Here we show that the mt genome of the haplosclerid demosponge Amphimedon queenslandica has features that it shares with both demosponges and eumetazoans. Although the A...
  8. Richards G, Simionato E, Perron M, Adamska M, Vervoort M, Degnan B. Sponge genes provide new insight into the evolutionary origin of the neurogenic circuit. Curr Biol. 2008;18:1156-61 pubmed publisher
    ..Here, we demonstrate that despite lacking neurons, the sponge Amphimedon queenslandica expresses the Notch-Delta signaling system and a proneural basic helix loop helix (bHLH) gene in a manner ..
  9. Sullivan J, Sher D, Eisenstein M, Shigesada K, Reitzel A, Marlow H, et al. The evolutionary origin of the Runx/CBFbeta transcription factors--studies of the most basal metazoans. BMC Evol Biol. 2008;8:228 pubmed publisher
    ..The expression data suggest a hypothesis that these genes may have played a role in nerve cell differentiation or maintenance in the common ancestor of cnidarians and bilaterians...

More Information


  1. Exposito J, Larroux C, Cluzel C, Valcourt U, Lethias C, Degnan B. Demosponge and sea anemone fibrillar collagen diversity reveals the early emergence of A/C clades and the maintenance of the modular structure of type V/XI collagens from sponge to human. J Biol Chem. 2008;283:28226-35 pubmed publisher
    ..The newly sequenced genomes of the choanoflagellate Monosiga brevicollis, the demosponge Amphimedon queenslandica, and the cnidarians Hydra magnipapillata (Hydra) and Nematostella vectensis (sea anemone) allow us to ..
  2. Tompkins Macdonald G, Gallin W, Sakarya O, Degnan B, Leys S, Boland L. Expression of a poriferan potassium channel: insights into the evolution of ion channels in metazoans. J Exp Biol. 2009;212:761-7 pubmed publisher
    ..We have carried out the first analysis of ion channels cloned from a marine sponge, Amphimedon queenslandica. Phylogenetic comparison of sequences encoding for poriferan inward-rectifier K(+) (Kir) channels ..
  3. Bridgham J, Eick G, Larroux C, Deshpande K, Harms M, Gauthier M, et al. Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor. PLoS Biol. 2010;8: pubmed publisher
    ..Our findings illustrate how a mechanistic dissection of protein evolution in a phylogenetic context can reveal the deep homology that links apparently "novel" molecular functions to a common ancestral form...
  4. Zhang X, Abreu J, Yokota C, MacDonald B, Singh S, Coburn K, et al. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell. 2012;149:1565-77 pubmed publisher
    ..TIKI proteins may represent potential therapeutic targets...