starlet sea anemone

Summary

Alias: Nematostella vectensis, Nematostella vectensis Stephenson, 1935

Top Publications

  1. Gui X, Yang H, Li T, Tan X, Shi P, Li M, et al. Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature. 2019;567:262-266 pubmed publisher
    ..Interestingly, STING from the sea anemone Nematostella vectensis induces autophagy but not interferons in response to stimulation by cGAMP, which suggests that induction ..
  2. Kühn F, Watt J, Potter B, Lückhoff A. Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR. Sci Rep. 2019;9:4985 pubmed publisher
    NvTRPM2 (Nematostella vectensis Transient Receptor Potential Melastatin 2), the species variant of the human apoptosis-related cation channel hTRPM2, is gated by ADP-ribose (ADPR) independently of the C-terminal NUDT9H domain that ..
  3. Röttinger E, Dahlin P, Martindale M. A framework for the establishment of a cnidarian gene regulatory network for "endomesoderm" specification: the inputs of ß-catenin/TCF signaling. PLoS Genet. 2012;8:e1003164 pubmed publisher
    ..the framework of a provisional cnidarian "endomesodermal" gene regulatory network in the sea anemone, Nematostella vectensis, by using a genome-wide microarray analysis on embryos in which the canonical Wnt/ß-catenin pathway was ..
  4. Tal Y, Ayalon A, Sharaev A, Kazir Z, Brekhman V, Lotan T. Continuous drug release by sea anemone Nematostella vectensis stinging microcapsules. Mar Drugs. 2014;12:734-45 pubmed publisher
    ..Here we show, for the first time, that the nematocysts of the starlet sea anemone Nematostella vectensis can be isolated and incorporated into a topical formulation for continuous drug delivery...
  5. Stefanik D, Lubinski T, Granger B, Byrd A, Reitzel A, Defilippo L, et al. Production of a reference transcriptome and transcriptomic database (EdwardsiellaBase) for the lined sea anemone, Edwardsiella lineata, a parasitic cnidarian. BMC Genomics. 2014;15:71 pubmed publisher
    ..Additionally, E. lineata is confamilial with the model cnidarian Nematostella vectensis, providing an opportunity for comparative genomic, molecular and organismal studies...
  6. Kumburegama S, Wijesena N, Xu R, Wikramanayake A. Strabismus-mediated primary archenteron invagination is uncoupled from Wnt/β-catenin-dependent endoderm cell fate specification in Nematostella vectensis (Anthozoa, Cnidaria): Implications for the evolution of gastrulation. Evodevo. 2011;2:2 pubmed publisher
    ..In the anthozoan cnidarian Nematostella vectensis, initial archenteron formation begins with bottle cell-induced buckling of the blastula epithelium at the ..
  7. Nathaniel Clarke D, Lowe C, James Nelson W. The cadherin-catenin complex is necessary for cell adhesion and embryogenesis in Nematostella vectensis. Dev Biol. 2019;447:170-181 pubmed publisher
    ..Here, we provide the first analysis of classical cadherins and catenins in the Starlet Sea Anemone, Nematostella vectensis. Gene expression, protein localization, siRNA-mediated knockdown of α-catenin, and calcium-dependent cell ..
  8. Layden M, Röttinger E, Wolenski F, Gilmore T, Martindale M. Microinjection of mRNA or morpholinos for reverse genetic analysis in the starlet sea anemone, Nematostella vectensis. Nat Protoc. 2013;8:924-34 pubmed publisher
    ..describe a protocol for microinjection of embryos for an emerging model system, the cnidarian sea anemone, Nematostella vectensis. In addition, we provide protocols for carrying out overexpression and knockdown of gene function through ..
  9. Moran Y, Genikhovich G, Gordon D, Wienkoop S, Zenkert C, Ozbek S, et al. Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones. Proc Biol Sci. 2012;279:1351-8 pubmed publisher
    ..Here we show, however, that the potent Type I neurotoxin of the sea anemone Nematostella vectensis, Nv1, is confined to ectodermal gland cells rather than nematocytes...

More Information

Publications102 found, 100 shown here

  1. Passamaneck Y, Martindale M. Cell proliferation is necessary for the regeneration of oral structures in the anthozoan cnidarian Nematostella vectensis. BMC Dev Biol. 2012;12:34 pubmed publisher
    ..Recently, the cnidarian Nematostella vectensis has shown potential as a model for studies of regeneration because of the ability to conduct comparative ..
  2. Reitzel A, Tarrant A, Levy O. Circadian clocks in the cnidaria: environmental entrainment, molecular regulation, and organismal outputs. Integr Comp Biol. 2013;53:118-30 pubmed publisher
    ..new empirical data supporting the presence of a conserved feed-forward loop in the starlet sea anemone, Nematostella vectensis. Furthermore, we discuss critical gaps in our current knowledge about the cnidarian clock, including the ..
  3. Marlow H, Matus D, Martindale M. Ectopic activation of the canonical wnt signaling pathway affects ectodermal patterning along the primary axis during larval development in the anthozoan Nematostella vectensis. Dev Biol. 2013;380:324-34 pubmed publisher
    ..In the anthozoan cnidarian Nematostella vectensis, the primary oral-aboral (O-Ab) axis first develops during the early embryonic stage...
  4. Sinigaglia C, Busengdal H, Leclère L, Technau U, Rentzsch F. The bilaterian head patterning gene six3/6 controls aboral domain development in a cnidarian. PLoS Biol. 2013;11:e1001488 pubmed publisher
    ..the function of conserved genetic regulators of bilaterian anterior development in the sea anemone Nematostella vectensis. We show that orthologs of the bilaterian anterior developmental genes six3/6, foxQ2, and irx have dynamic ..
  5. Reitzel A, Passamaneck Y, Karchner S, Franks D, Martindale M, Tarrant A, et al. Aryl hydrocarbon receptor (AHR) in the cnidarian Nematostella vectensis: comparative expression, protein interactions, and ligand binding. Dev Genes Evol. 2014;224:13-24 pubmed publisher
    ..We describe the developmental expression of AHR from the sea anemone Nematostella vectensis and compare its expression with three other members of the bHLH-PAS family (AHR nuclear translocator (ARNT)..
  6. Moiseeva E, Rabinowitz C, Paz G, Rinkevich B. Histological study on maturation, fertilization and the state of gonadal region following spawning in the model sea anemone, Nematostella vectensis. PLoS ONE. 2017;12:e0182677 pubmed publisher
    The starlet sea-anemone Nematostella vectensis has emerged as a model organism in developmental biology. Still, our understanding of various biological features, including reproductive biology of this model species are in its infancy...
  7. Karabulut A, He S, Chen C, McKinney S, Gibson M. Electroporation of short hairpin RNAs for rapid and efficient gene knockdown in the starlet sea anemone, Nematostella vectensis. Dev Biol. 2019;448:7-15 pubmed publisher
    ..gene-specific knockdown by microinjection of short hairpin RNA (shRNA) was applied in the sea anemone Nematostella vectensis, demonstrating that the shRNA approach can be used for efficient and robust sequence-specific knockdown of ..
  8. Schnitzler C, Pang K, Powers M, Reitzel A, Ryan J, Simmons D, et al. Genomic organization, evolution, and expression of photoprotein and opsin genes in Mnemiopsis leidyi: a new view of ctenophore photocytes. BMC Biol. 2012;10:107 pubmed publisher
    ..in the genomes of the non-luminescent sponge Amphimedon queenslandica and the non-luminescent cnidarian Nematostella vectensis, and phylogenomic analysis demonstrated that photoprotein genes arose at the base of all animals...
  9. Renfer E, Amon Hassenzahl A, Steinmetz P, Technau U. A muscle-specific transgenic reporter line of the sea anemone, Nematostella vectensis. Proc Natl Acad Sci U S A. 2010;107:104-8 pubmed publisher
    The sea anemone, Nematostella vectensis, has become an attractive new model organism for comparative genomics and evolutionary developmental biology...
  10. Reitzel A, Herrera S, Layden M, Martindale M, Shank T. Going where traditional markers have not gone before: utility of and promise for RAD sequencing in marine invertebrate phylogeography and population genomics. Mol Ecol. 2013;22:2953-70 pubmed publisher
    ..DNA sequencing (RAD-seq) to identify SNPs in natural populations of the sea anemone Nematostella vectensis, an emerging cnidarian model with a broad geographic range in estuarine habitats in North and South ..
  11. Sunagar K, Columbus Shenkar Y, Fridrich A, Gutkovich N, Aharoni R, Moran Y. Cell type-specific expression profiling unravels the development and evolution of stinging cells in sea anemone. BMC Biol. 2018;16:108 pubmed publisher
    ..In this study, we generated a nematocyte reporter transgenic line of the sea anemone Nematostella vectensis using the CRISPR/Cas9 system...
  12. Calcino A, Fernandez Valverde S, Taft R, Degnan B. Diverse RNA interference strategies in early-branching metazoans. BMC Evol Biol. 2018;18:160 pubmed publisher
    ..and piRNAs from the sponge Amphimedon queenslandica, the ctenophore Mnemiopsis leidyi and the cnidarian Nematostella vectensis using a computational approach that clusters mapped small RNA sequences and annotates each cluster based ..
  13. Campbell A, Dykes A, Mire P. Periodic, moderate water flow reversibly increases hair bundle density and size in Nematostella vectensis. J Exp Biol. 2018;221: pubmed publisher
    ..Therefore, anemone hair bundles are dynamically and reversibly modified by periodic, moderate flow to become more abundant and robust. These findings may have relevance to hair cells in acoustico-lateralis systems of higher animals. ..
  14. He S, del Viso F, Chen C, Ikmi A, Kroesen A, Gibson M. An axial Hox code controls tissue segmentation and body patterning in Nematostella vectensis. Science. 2018;361:1377-1380 pubmed publisher
    ..network controls radial segmentation of the larval endoderm during development of the sea anemone Nematostella vectensis. Loss of Hox-Gbx activity also elicits marked defects in tentacle patterning along the directive (..
  15. Modepalli V, Fridrich A, Agron M, Moran Y. The methyltransferase HEN1 is required in Nematostella vectensis for microRNA and piRNA stability as well as larval metamorphosis. PLoS Genet. 2018;14:e1007590 pubmed publisher
    ..Knowing that an ortholog of HEN1 is widely expressed in the sea anemone Nematostella vectensis, we tested in this work whether it mediates the stabilization of its sRNAs...
  16. Richards G, Rentzsch F. Transgenic analysis of a SoxB gene reveals neural progenitor cells in the cnidarian Nematostella vectensis. Development. 2014;141:4681-9 pubmed publisher
    ..We address this question by analysing neurogenesis in an anthozoan cnidarian, Nematostella vectensis. Using a transgenic reporter line, we show that NvSoxB(2) - an orthologue of bilaterian SoxB genes that ..
  17. Sebé Pedrós A, Saudemont B, Chomsky E, Plessier F, Mailhé M, Renno J, et al. Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq. Cell. 2018;173:1520-1534.e20 pubmed publisher
    ..we perform whole-organism single-cell transcriptomics to map adult and larval cell types in the cnidarian Nematostella vectensis, a non-bilaterian animal with complex tissue-level body-plan organization...
  18. Dubuc T, Stephenson T, Rock A, Martindale M. Hox and Wnt pattern the primary body axis of an anthozoan cnidarian before gastrulation. Nat Commun. 2018;9:2007 pubmed publisher
    ..Here we report a previously unrecognized domain of Hox expression in the starlet sea anemone, Nematostella vectensis, beginning at early blastula stages...
  19. Gong Q, Garvey K, Qian C, Yin I, Wong G, Tucker R. Integrins of the starlet sea anemone Nematostella vectensis. Biol Bull. 2014;227:211-20 pubmed
    ..Here we describe two α subunits and four β subunits from the starlet sea anemone Nematostella vectensis. Phylogenetic analysis suggests that the α subunits are most closely related to RGD- and LDV-dependent ..
  20. Moran Y, Zakon H. The evolution of the four subunits of voltage-gated calcium channels: ancient roots, increasing complexity, and multiple losses. Genome Biol Evol. 2014;6:2210-7 pubmed publisher
    ..We characterized by in situ hybridization the tissue distribution of alpha subunits in the sea anemone Nematostella vectensis, a nonbilaterian animal possessing all three Ca(v) subfamilies common to Bilateria...
  21. Ruiz Ramos D, Baums I. Microsatellite abundance across the Anthozoa and Hydrozoa in the phylum Cnidaria. BMC Genomics. 2014;15:939 pubmed publisher
    ..Sequences from the three available cnidarian genomes (Nematostella vectensis, Hydra magnipapillata and Acropora digitifera) were added to the analysis for a total of eleven species ..
  22. Dubuc T, Dattoli A, Babonis L, Salinas Saavedra M, Röttinger E, Martindale M, et al. In vivo imaging of Nematostella vectensis embryogenesis and late development using fluorescent probes. BMC Cell Biol. 2014;15:44 pubmed publisher
    ..The cnidarian model, Nematostella vectensis, is a unique system in which embryology and regeneration are both studied, making it an ideal candidate to ..
  23. Sinigaglia C, Busengdal H, Lerner A, Oliveri P, Rentzsch F. Molecular characterization of the apical organ of the anthozoan Nematostella vectensis. Dev Biol. 2015;398:120-33 pubmed publisher
    ..of this structure we have characterised the molecular composition of the apical organ of the sea anemone Nematostella vectensis. In a microarray-based comparison of the gene expression profiles of planulae with either a wildtype or an ..
  24. Hayward D, Grasso L, Saint R, Miller D, Ball E. The organizer in evolution-gastrulation and organizer gene expression highlight the importance of Brachyury during development of the coral, Acropora millepora. Dev Biol. 2015;399:337-47 pubmed publisher
    ..it has only been subjected to detailed investigation during embryonic development of the sea anemone, Nematostella vectensis. As a step toward establishing the extent to which findings in Nematostella can be generalized across the ..
  25. Tang P, Watson G. Proteomic identification of hair cell repair proteins in the model sea anemone Nematostella vectensis. Hear Res. 2015;327:245-56 pubmed publisher
    ..A model is proposed that considers the function of extracellular Hsp70s and 20S proteasomes in the repair of damaged hair cells. ..
  26. Warner J, Guerlais V, Amiel A, Johnston H, Nedoncelle K, Röttinger E. NvERTx: a gene expression database to compare embryogenesis and regeneration in the sea anemone Nematostella vectensis. Development. 2018;145: pubmed publisher
    ..The site is also home to the results of gene clustering analyses, to further mine the data and identify groups of co-expressed genes. The site can be accessed at http://nvertx.kahikai.org. ..
  27. Pukhlyakova E, Aman A, Elsayad K, Technau U. ?-Catenin-dependent mechanotransduction dates back to the common ancestor of Cnidaria and Bilateria. Proc Natl Acad Sci U S A. 2018;115:6231-6236 pubmed publisher
    ..Here, we investigate mechanosensitive gene expression during gastrulation of the starlet sea anemone Nematostella vectensis, a cnidarian model organism...
  28. Ikmi A, McKinney S, Delventhal K, Gibson M. TALEN and CRISPR/Cas9-mediated genome editing in the early-branching metazoan Nematostella vectensis. Nat Commun. 2014;5:5486 pubmed publisher
    ..systems to induce targeted mutations and homologous recombination-mediated transgenesis in the sea anemone Nematostella vectensis. We also present a new method to isolate genetically modified animals using engineered selection cassettes ..
  29. Tarrant A, Gilmore T, Reitzel A, Levy O, Technau U, Martindale M. Current directions and future perspectives from the third Nematostella research conference. Zoology (Jena). 2015;118:135-40 pubmed publisher
    The third Nematostella vectensis Research Conference took place in December 2013 in Eilat, Israel, as a satellite to the 8th International Conference on Coelenterate Biology. The starlet sea anemone, N...
  30. Waller S, Knighton L, Crabtree L, Perkins A, Reitzel A, Truman A. Characterizing functional differences in sea anemone Hsp70 isoforms using budding yeast. Cell Stress Chaperones. 2018;23:933-941 pubmed publisher
    ..we undertook analysis of three principal Hsp70 isoforms NvHsp70A, B, and D from the starlet sea anemone Nematostella vectensis. The functionality of Hsp70 isoforms in the starlet sea anemone was assessed through transcriptional ..
  31. Krishnan A, Schiöth H. The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system. J Exp Biol. 2015;218:562-71 pubmed publisher
    ..GPCR repertories from four pre-bilaterian metazoan genomes were compared. This includes the cnidarian Nematostella vectensis and the ctenophore Mnemiopsis leidyi, which have primitive nervous systems (nerve nets), the demosponge ..
  32. Richards G, Rentzsch F. Regulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes. Development. 2015;142:3332-42 pubmed publisher
    ..We address this question in the sea anemone Nematostella vectensis, a representative of the Cnidaria, the sister clade to the Bilateria...
  33. Amiel A, Johnston H, Nedoncelle K, Warner J, Ferreira S, Röttinger E. Characterization of Morphological and Cellular Events Underlying Oral Regeneration in the Sea Anemone, Nematostella vectensis. Int J Mol Sci. 2015;16:28449-71 pubmed publisher
    ..The sea anemone Nematostella vectensis is a well-established system for the study of development and evolution that is receiving increased ..
  34. Dattoli A, Hink M, Dubuc T, Teunisse B, Goedhart J, Röttinger E, et al. Domain analysis of the Nematostella vectensis SNAIL ortholog reveals unique nucleolar localization that depends on the zinc-finger domains. Sci Rep. 2015;5:12147 pubmed publisher
    ..They arose early during evolution, and in cnidarians such as Nematostella vectensis, NvSNAILA/B are detected in invaginating tissues during gastrulation...
  35. Robertson H. The Insect Chemoreceptor Superfamily Is Ancient in Animals. Chem Senses. 2015;40:609-14 pubmed publisher
    ..GR-Like (GRL) genes are present in the genomes of the placozoan Trichoplax adhaerens, an anemone Nematostella vectensis, a coral Acropora digitifera, a polychaete Capitella teleta, a leech Helobdella robusta, the nematode ..
  36. Guo L, Accorsi A, He S, Guerrero Hernández C, Sivagnanam S, McKinney S, et al. An adaptable chromosome preparation methodology for use in invertebrate research organisms. BMC Biol. 2018;16:25 pubmed publisher
    ..the freshwater apple snail Pomacea canaliculata (phylum Mollusca), and the starlet sea anemone Nematostella vectensis (phylum Cnidaria)...
  37. Sullivan J, Wolenski F, Reitzel A, French C, Traylor Knowles N, Gilmore T, et al. Two alleles of NF-kappaB in the sea anemone Nematostella vectensis are widely dispersed in nature and encode proteins with distinct activities. PLoS ONE. 2009;4:e7311 pubmed publisher
    ..We characterized two NF-kappaB alleles in the sea anemone Nematostella vectensis that differ at nineteen single-nucleotide polymorphisms (SNPs)...
  38. Desvignes T, Pontarotti P, Bobe J. Nme gene family evolutionary history reveals pre-metazoan origins and high conservation between humans and the sea anemone, Nematostella vectensis. PLoS ONE. 2010;5:e15506 pubmed publisher
    ..When considering the entire Nme family, the starlet sea anemone is the studied metazoan species exhibiting the most conserved gene and protein sequence features with ..
  39. Maas A, Jones I, Reitzel A, Tarrant A. Daily cycle in oxygen consumption by the sea anemone Nematostella vectensis Stephenson. Biol Open. 2016;5:161-4 pubmed publisher
    ..To explore a possible circadian metabolic cycle, we maintained the anemone Nematostella vectensis in a 12 h light/dark cycle, a reversed light cycle, or in constant darkness...
  40. Botman D, Jansson F, Röttinger E, Martindale M, de Jong J, Kaandorp J. Analysis of a spatial gene expression database for sea anemone Nematostella vectensis during early development. BMC Syst Biol. 2015;9:63 pubmed publisher
    ..distribution of many genes has been visualized during the embryonic development in the starlet sea anemone Nematostella vectensis in the last decade...
  41. Technau U, Schwaiger M. Recent advances in genomics and transcriptomics of cnidarians. Mar Genomics. 2015;24 Pt 2:131-8 pubmed publisher
    ..The sea anemone Nematostella vectensis, and possibly cnidarians in general, does not only share its complex gene repertoire with bilaterians, but ..
  42. Saina M, Busengdal H, Sinigaglia C, Petrone L, Oliveri P, Rentzsch F, et al. A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning. Nat Commun. 2015;6:6243 pubmed publisher
    ..Surprisingly, two Grls in the cnidarian Nematostella vectensis, NvecGrl1 and NvecGrl2, are expressed early in development, in the blastula and gastrula, but not at later ..
  43. Okazaki N, Motomura S, Okazoe N, Yano D, Suzuki T. Cooperativity and evolution of Tetrahymena two-domain arginine kinase. Int J Biol Macromol. 2015;79:696-703 pubmed publisher
    ..We performed PMF analyses for two other phosphagen kinases (PKs) with myristoylation signals, an AK from Nematostella vectensis and a PK from Ectocarpus siliculosus...
  44. Oren M, Tarrant A, Alon S, Simon Blecher N, Elbaz I, Appelbaum L, et al. Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis. Sci Rep. 2015;5:11418 pubmed publisher
    ..behavioral patterns and identified potential components of the circadian clock in the starlet sea anemone, Nematostella vectensis: a model cnidarian which lacks algal symbionts...
  45. Li X, Martinson A, Layden M, Diatta F, Sberna A, Simmons D, et al. Ether-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor. J Exp Biol. 2015;218:526-36 pubmed publisher
    ..Here we show that Eag and Elk channels from the sea anemone Nematostella vectensis (NvEag and NvElk) also share high functional conservation with mammalian channels...
  46. Kranzusch P, Wilson S, Lee A, Berger J, Doudna J, Vance R. Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol Cell. 2015;59:891-903 pubmed publisher
    ..the ancient origins of human cGAMP signaling by discovery of a functional cGAS-STING pathway in Nematostella vectensis, an anemone species >500 million years diverged from humans...
  47. Helm R, Martín Díaz M, Tarrant A. Phylogenetic analysis of cnidarian peroxiredoxins and stress-responsive expression in the estuarine sea anemone Nematostella vectensis. Comp Biochem Physiol A Mol Integr Physiol. 2018;221:32-43 pubmed publisher
    ..diversity in cnidarians and to gain insight into their function in one cnidarian-the sea anemone Nematostella vectensis. Phylogenetic analysis using all six known PRX subfamilies (PRX1-4, PRX5, PRX6, PRXQ/AHPE1, TPX, BCP-PRXQ) ..
  48. Leclère L, Rentzsch F. RGM regulates BMP-mediated secondary axis formation in the sea anemone Nematostella vectensis. Cell Rep. 2014;9:1921-30 pubmed publisher
    ..NvRGM is a key positive regulator of BMP signaling during secondary axis establishment in the cnidarian Nematostella vectensis. NvRGM regulates first the generation and later the shape of a BMP-dependent Smad1/5/8 gradient with peak ..
  49. Kelava I, Rentzsch F, Technau U. Evolution of eumetazoan nervous systems: insights from cnidarians. Philos Trans R Soc Lond B Biol Sci. 2015;370: pubmed publisher
    ..underlying the development of a cnidarian nervous system-in particular the nervous system of the anthozoan Nematostella vectensis. It appears that much of the genetic network of the nervous system development is partly conserved between ..
  50. Roopin M, Levy O. Melatonin distribution reveals clues to its biological significance in basal metazoans. PLoS ONE. 2012;7:e52266 pubmed publisher
    ..Hitherto unknown morphological determinants of melatonin distribution were evaluated in Nematostella vectensis by detecting melatonin immunoreactivity and examining the spatial gene expression patterns of putative ..
  51. Salinas Saavedra M, Stephenson T, Dunn C, Martindale M. Par system components are asymmetrically localized in ectodermal epithelia, but not during early development in the sea anemone Nematostella vectensis. Evodevo. 2015;6:20 pubmed publisher
    ..the localization of different components of the Par system during early development of the sea anemone Nematostella vectensis, a member of the clade Cnidaria, the sister group to bilaterian animals. Immunostaining using specific N...
  52. Yang X, Pei J, Kaeser Woo Y, Bacaj T, Grishin N, Südhof T. Evolutionary conservation of complexins: from choanoflagellates to mice. EMBO Rep. 2015;16:1308-17 pubmed publisher
    ..We show that complexin from Nematostella vectensis, a cnidarian sea anemone far separated from mammals in metazoan evolution, functionally replaces mouse ..
  53. Song X, Du J, Zhu W, Jin P, Ma F. Identification and characterization of an apoptosis-stimulating protein of p53 (ASPP) gene from Branchiostoma belcheri: Insights into evolution of ASPP gene family. Fish Shellfish Immunol. 2016;49:268-74 pubmed publisher
    ..analyses indicated that the members of ASPP protein family might be present in a common ancestor of Nematostella vectensis and underwent positive selective in the evolutionary history...
  54. Leach W, Macrander J, Peres R, Reitzel A. Transcriptome-wide analysis of differential gene expression in response to light:dark cycles in a model cnidarian. Comp Biochem Physiol Part D Genomics Proteomics. 2018;26:40-49 pubmed publisher
    ..The starlet sea anemone, Nematostella vectensis, has oscillating patterns of locomotion and respiration, as well as the molecular components of a putative ..
  55. Layden M. Cnidarian Zic Genes. Adv Exp Med Biol. 2018;1046:27-39 pubmed publisher
    ..focus on how expression of cnidarian zic homologs in the medusozoan Hydra vulgaris and the anthozoan Nematostella vectensis informs our understanding of the putative ancestral roles zic homologs played in the cnidarian-bilaterian ..
  56. Kühn F, Kühn C, Lückhoff A. Functional characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells. Sci Rep. 2015;5:8032 pubmed publisher
    ..structure-function relationship of this channel, we characterised a TRPM2 orthologue from the cnidarian Nematostella vectensis, after its expression in a human cell line...
  57. Warren C, Kassir E, Spurlin J, Martinez J, Putnam N, Farach Carson M. Evolution of the perlecan/HSPG2 gene and its activation in regenerating Nematostella vectensis. PLoS ONE. 2015;10:e0124578 pubmed publisher
    ..After the recent sequencing of their genomes, the cnidarian Nematostella vectensis and the placozoan Trichoplax adhaerens have become favorite models for studying tissue regeneration and ..
  58. Kirillova A, Genikhovich G, Pukhlyakova E, Demilly A, Kraus Y, Technau U. Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates. Proc Natl Acad Sci U S A. 2018;115:1813-1818 pubmed publisher
    ..facing a new developmental context, the aggregates of dissociated embryonic cells of the sea anemone Nematostella vectensis take an alternative developmental trajectory...
  59. Babonis L, Martindale M, Ryan J. Do novel genes drive morphological novelty? An investigation of the nematosomes in the sea anemone Nematostella vectensis. BMC Evol Biol. 2016;16:114 pubmed publisher
    ..Nematosomes, the free-floating cellular masses that circulate through the body cavity of the sea anemone Nematostella vectensis, are the defining apomorphy of the genus Nematostella and are a useful model for understanding the ..
  60. Menard S, Watson G. Evidence for two populations of hair bundles in the sea anemone, Nematostella vectensis. Comp Biochem Physiol A Mol Integr Physiol. 2017;208:14-23 pubmed publisher
    ..Thus, two populations of hair bundles may be present on tentacles of sea anemones: those that are CD-resistant and those that are CD-sensitive. The functions of these hair bundles may be distinct. ..
  61. Ragkousi K, Marr K, McKinney S, Ellington L, Gibson M. Cell-Cycle-Coupled Oscillations in Apical Polarity and Intercellular Contact Maintain Order in Embryonic Epithelia. Curr Biol. 2017;27:1381-1386 pubmed publisher
    ..Representing the early-branching non-bilaterian phylum Cnidaria, embryos of the sea anemone Nematostella vectensis undergo rapid synchronous cell divisions and ultimately give rise to a diploblastic epithelial body plan ..
  62. Abdol A, Röttinger E, Jansson F, Kaandorp J. A novel technique to combine and analyse spatial and temporal expression datasets: A case study with the sea anemone Nematostella vectensis to identify potential gene interactions. Dev Biol. 2017;428:204-214 pubmed publisher
    ..Finally, we validate our methods and results by predicting the repressor effect of NvErg on NvBra in the central domain during the gastrulation that has recently been confirmed by functional analysis. ..
  63. Wijesena N, Simmons D, Martindale M. Antagonistic BMP-cWNT signaling in the cnidarian Nematostella vectensis reveals insight into the evolution of mesoderm. Proc Natl Acad Sci U S A. 2017;114:E5608-E5615 pubmed publisher
    ..for a specific role for BMP signaling during endomesoderm specification in the early branching metazoan Nematostella vectensis (an anthozoan cnidarian)...
  64. Nicosia A, Bennici C, Biondo G, Costa S, Di Natale M, Masullo T, et al. Characterization of Translationally Controlled Tumour Protein from the Sea Anemone Anemonia viridis and Transcriptome Wide Identification of Cnidarian Homologues. Genes (Basel). 2018;9: pubmed publisher
    ..The release of the genome sequence of Acropora digitifera, Exaiptasia pallida, Nematostella vectensis and Hydra vulgaris enabled a comprehensive study of the molecular evolution of TCTP family ..
  65. Layden M, Johnston H, Amiel A, Havrilak J, Steinworth B, Chock T, et al. MAPK signaling is necessary for neurogenesis in Nematostella vectensis. BMC Biol. 2016;14:61 pubmed publisher
    ..Lastly, analysis of the MAPK targets in the early embryo suggests that MAPK signaling is critical not only to neurogenesis, but also endomesoderm formation and aboral patterning. ..
  66. Rabinowitz C, Moiseeva E, Rinkevich B. In vitro cultures of ectodermal monolayers from the model sea anemone Nematostella vectensis. Cell Tissue Res. 2016;366:693-705 pubmed
    ..and culturing of intact ectodermal tissue layers from a model marine invertebrate, the sea anemone Nematostella vectensis. A methodology is described in which a brief exposure of the animal to the mucolytic agent N-acetyl-L-..
  67. Bossert P, Thomsen G. Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis. J Vis Exp. 2017;: pubmed publisher
    ..The starlet sea anemone, Nematostella vectensis, is an emerging model organism for regeneration...
  68. Busengdal H, Rentzsch F. Unipotent progenitors contribute to the generation of sensory cell types in the nervous system of the cnidarian Nematostella vectensis. Dev Biol. 2017;431:59-68 pubmed publisher
    ..Here we use a cnidarian model organism, Nematostella vectensis, to gain insight into the generation of neural cell type diversity in a non-bilaterian animal...
  69. Sako K, Rensburg I, Clift S, Naidoo V. The use of primary murine fibroblasts to ascertain if Spirocerca lupi secretory/excretory protein products are mitogenic ex vivo. BMC Vet Res. 2017;13:262 pubmed publisher
    ..the presence of 9 protein compounds, of which three were identified as non-specific proteins isolated from Nematostella vectensis, Caenorhabditis brenneri and Sus scrofa, with the rest being unknown...
  70. Tarrant A, Payton S, Reitzel A, Porter D, Jenny M. Ultraviolet radiation significantly enhances the molecular response to dispersant and sweet crude oil exposure in Nematostella vectensis. Mar Environ Res. 2018;134:96-108 pubmed publisher
    ..b>Nematostella vectensis (starlet sea anemone) is a useful model for investigating novel and evolutionarily conserved cellular and ..
  71. Bause M, van der Horst R, Rentzsch F. Glypican1/2/4/6 and sulfated glycosaminoglycans regulate the patterning of the primary body axis in the cnidarian Nematostella vectensis. Dev Biol. 2016;414:108-20 pubmed publisher
    ..this study we investigate the role of glypicans in the embryonic and larval development of the sea anemone Nematostella vectensis, a member of the non-bilaterian clade Cnidaria...
  72. Clarke D, Miller P, Lowe C, Weis W, NELSON W. Characterization of the Cadherin-Catenin Complex of the Sea Anemone Nematostella vectensis and Implications for the Evolution of Metazoan Cell-Cell Adhesion. Mol Biol Evol. 2016;33:2016-29 pubmed publisher
    ..and actin-binding properties of the CCC are conserved in a nonbilaterian animal, the sea anemone Nematostella vectensis We demonstrated that N...
  73. Rentzsch F, Technau U. Genomics and development of Nematostella vectensis and other anthozoans. Curr Opin Genet Dev. 2016;39:63-70 pubmed publisher
    ..With a focus on the sea anemone Nematostella vectensis we describe new findings about the development of the nervous system from neural progenitor cells and how ..
  74. Kühn F, Kühn C, Winking M, Hoffmann D, Lückhoff A. ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain. PLoS ONE. 2016;11:e0158060 pubmed publisher
    ..The TRPM2 orthologue from Nematostella vectensis (nv) is also stimulated by ADP-ribose but not by the oxidant hydrogen peroxide...
  75. Schaffer A, Bazarsky M, Levy K, Chalifa Caspi V, Gat U. A transcriptional time-course analysis of oral vs. aboral whole-body regeneration in the Sea anemone Nematostella vectensis. BMC Genomics. 2016;17:718 pubmed publisher
    ..The extent of this ability varies greatly in different animals with the sea anemone Nematostella vectensis, a basal cnidarian model animal, displaying remarkable whole-body regeneration competence...
  76. Kühn F, Mathis W, Cornelia K, Hoffmann D, Lückhoff A. Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis. Sci Rep. 2017;7:7245 pubmed publisher
    The archetypal TRPM2-like channel of the sea anemone Nematostella vectensis is gated by ADPR like its human orthologue but additionally exhibits properties of other vertebrate TRPM channels...
  77. Renfer E, Technau U. Meganuclease-assisted generation of stable transgenics in the sea anemone Nematostella vectensis. Nat Protoc. 2017;12:1844-1854 pubmed publisher
    The sea anemone Nematostella vectensis is a model system used by a rapidly growing research community for comparative genomics, developmental biology and ecology...
  78. Leclère L, Bause M, Sinigaglia C, Steger J, Rentzsch F. Development of the aboral domain in Nematostella requires ?-catenin and the opposing activities of Six3/6 and Frizzled5/8. Development. 2016;143:1766-77 pubmed publisher
    ..Investigating the early steps of aboral pole formation in the sea anemone Nematostella vectensis, we found that, at blastula stage, oral genes are expressed before aboral genes and that Nv?-catenin ..
  79. Macrander J, Daly M. Evolution of the Cytolytic Pore-Forming Proteins (Actinoporins) in Sea Anemones. Toxins (Basel). 2016;8: pubmed
    ..We also found clusters of six actinoporin-like genes in five species of sea anemone (Nematostella vectensis, Stomphia coccinea, Epiactis japonica, Heteractis crispa, and Diadumene ..
  80. Steinmetz P, Aman A, Kraus J, Technau U. Gut-like ectodermal tissue in a sea anemone challenges germ layer homology. Nat Ecol Evol. 2017;1:1535-1542 pubmed publisher
    ..of numerous 'endodermal' and 'mesodermal' transcription factor orthologues in the anthozoan sea anemone Nematostella vectensis. Surprisingly, we find that the developing pharyngeal ectoderm and its derivatives display a transcription-..
  81. Rentzsch F, LAYDEN M, Manuel M. The cellular and molecular basis of cnidarian neurogenesis. Wiley Interdiscip Rev Dev Biol. 2017;6: pubmed publisher
    ..Cnidarian neurogenesis is currently best understood in the sea anemone Nematostella vectensis, where it includes epithelial neural progenitor cells that express transcription factors of the soxB and ..
  82. Servetnick M, Steinworth B, Babonis L, Simmons D, Salinas Saavedra M, Martindale M. Cas9-mediated excision of Nematostella brachyury disrupts endoderm development, pharynx formation and oral-aboral patterning. Development. 2017;144:2951-2960 pubmed publisher
    ..evolution of definitive mesoderm, we excised the gene using CRISPR/Cas9 in the diploblastic cnidarian Nematostella vectensisNvbrachyury is normally expressed in precursors of the pharynx, which separates endoderm from ..
  83. Toporkova Y, Gorina S, Mukhitova F, Hamberg M, Ilyina T, Mukhtarova L, et al. Identification of CYP443D1 (CYP74 clan) of Nematostella vectensis as a first cnidarian epoxyalcohol synthase and insights into its catalytic mechanism. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:1099-1109 pubmed publisher
    ..A novel putative CYP74 clan gene CYP443D1 of the starlet sea anemone (Nematostella vectensis, Cnidaria) has been cloned, and the properties of the corresponding recombinant protein have been studied ..
  84. Praher D, Zimmermann B, Genikhovich G, Columbus Shenkar Y, Modepalli V, Aharoni R, et al. Characterization of the piRNA pathway during development of the sea anemone Nematostella vectensis. RNA Biol. 2017;14:1727-1741 pubmed publisher
    ..Here we investigate the piRNA pathway during the development of Nematostella vectensis, a well-established model system belonging to Cnidaria, the sister group to Bilateria...
  85. Abdol A, Bedard A, Lánský I, Kaandorp J. High-throughput method for extracting and visualizing the spatial gene expressions from in situ hybridization images: A case study of the early development of the sea anemone Nematostella vectensis. Gene Expr Patterns. 2018;27:36-45 pubmed publisher
  86. Sullivan J, Sher D, Eisenstein M, Shigesada K, Reitzel A, Marlow H, et al. The evolutionary origin of the Runx/CBFbeta transcription factors--studies of the most basal metazoans. BMC Evol Biol. 2008;8:228 pubmed publisher
    ..The expression data suggest a hypothesis that these genes may have played a role in nerve cell differentiation or maintenance in the common ancestor of cnidarians and bilaterians...
  87. Murai M, Chruszcz M, Reddy G, Grembecka J, Cierpicki T. Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein. J Biol Chem. 2011;286:31742-8 pubmed publisher
    ..Here, we report the first crystal structure of menin homolog from Nematostella vectensis. Due to a very high sequence similarity, the Nematostella menin is a close homolog of human menin, and ..
  88. Allaire K, Watson G. Rho participates in chemoreceptor-induced changes in morphology to hair bundle mechanoreceptors of the sea anemone, Nematostella vectensis. Comp Biochem Physiol A Mol Integr Physiol. 2013;165:139-48 pubmed publisher
    ..Data from experiments using heptanol, a gap junction uncoupler, indicate that cell-cell communication is required in order for activated chemoreceptors to induce morphological changes to the hair bundles. ..
  89. Ebchuqin E, Yokota N, Yamada L, Yasuoka Y, Akasaka M, Arakawa M, et al. Evidence for participation of GCS1 in fertilization of the starlet sea anemone Nematostella vectensis: implication of a common mechanism of sperm-egg fusion in plants and animals. Biochem Biophys Res Commun. 2014;451:522-8 pubmed publisher
    ..common mechanism, we investigated the role of GCS1 in animal fertilization using a sea anemone (Cnidaria), Nematostella vectensis. Although the existence of the GCS1 gene in N...
  90. Watanabe H, Kuhn A, Fushiki M, Agata K, Özbek S, Fujisawa T, et al. Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis. Nat Commun. 2014;5:5536 pubmed publisher
    ..We addressed this question in Nematostella vectensis, a member of cnidarians, the ancient sister group of bilaterians...
  91. Smith C, Abdallah S, Wong Y, Le P, Harracksingh A, Artinian L, et al. Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue. J Gen Physiol. 2017;149:483-510 pubmed publisher
    ..TCav3 is the most divergent metazoan T-type calcium channel and thus provides an evolutionary perspective on Cav3 channel structure-function properties, ion selectivity, and cellular physiology. ..
  92. Brennan J, Messerschmidt J, Williams L, Matthews B, Reynoso M, Gilmore T. Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development. Proc Natl Acad Sci U S A. 2017;114:E10122-E10131 pubmed publisher
    ..TLRs also have roles in development in many species. The sea anemone Nematostella vectensis is a useful cnidarian model to study the origins of TLR signaling because its genome encodes a single ..