Schistosoma mansoni

Summary

Alias:

Top Publications

  1. McVeigh P, Mair G, Novozhilova E, Day A, Zamanian M, Marks N, et al. Schistosome I/Lamides--a new family of bioactive helminth neuropeptides. Int J Parasitol. 2011;41:905-13 pubmed publisher
    ..biological and functional characterisation of one of the peptides from the trematode parasite of humans, Schistosoma mansoni. Bioinformatics and Rapid Amplification of cDNA Ends (RACE)-PCR were used to identify the complete S...
  2. Geyer K, Rodríguez López C, Chalmers I, Munshi S, Truscott M, Heald J, et al. Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni. Nat Commun. 2011;2:424 pubmed publisher
    Similar to other metazoan pathogens, Schistosoma mansoni undergoes transcriptional and developmental regulation during its complex lifecycle and host interactions...
  3. Berriman M, Haas B, LoVerde P, Wilson R, Dillon G, Cerqueira G, et al. The genome of the blood fluke Schistosoma mansoni. Nature. 2009;460:352-8 pubmed publisher
    b>Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke...
  4. Fitzpatrick J, Fuentes J, Chalmers I, Wynn T, Modolell M, Hoffmann K, et al. Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity. Int J Parasitol. 2009;39:267-79 pubmed publisher
    ..We demonstrate for the first time that several developmental stages of the human parasite Schistosoma mansoni express arginase, which is responsible for the hydrolysis of l-arginine to l-ornithine and urea...
  5. Cardoso F, Macedo G, Gava E, Kitten G, Mati V, de Melo A, et al. Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection. PLoS Negl Trop Dis. 2008;2:e308 pubmed publisher
    ..results have recently been obtained using membrane-spanning protein antigens from the tegument of Schistosoma mansoni. Our group recently identified Sm29, another antigen that is present at the adult worm tegument surface...
  6. Mei H, Hirai H, Tanaka M, Hong Z, Rekosh D, Loverde P. Schistosoma mansoni: cloning and characterization of a gene encoding cytosolic Cu/Zn superoxide dismutase. Exp Parasitol. 1995;80:250-9 pubmed
    Two forms of Cu/Zn superoxide dismutase (SOD) have been identified in Schistosoma mansoni, signal peptide-containing SOD (SP-SOD, Simurda et al., 1988, Exp. Parasitol. 67, 73-84) and cytosolic SOD (CT-SOD, Hong et al., 1992, Exp...
  7. Fitzpatrick J, Hoffmann K. Dioecious Schistosoma mansoni express divergent gene repertoires regulated by pairing. Int J Parasitol. 2006;36:1081-9 pubmed
    Pairing of adult Schistosoma mansoni parasites initiates a cascade of events including mating and egg production that ultimately leads to immuno-pathological lesions during schistosomiasis...
  8. Milligan J, Jolly E. Identification and characterization of a Mef2 transcriptional activator in schistosome parasites. PLoS Negl Trop Dis. 2012;6:e1443 pubmed publisher
    ..Here, we identify and characterize Mef2 from the schistosome worm Schistosoma mansoni (SmMef2)...
  9. Weston D, Kemp W. Schistosoma mansoni: comparison of cloned tropomyosin antigens shared between adult parasites and Biomphalaria glabrata. Exp Parasitol. 1993;76:358-70 pubmed publisher
    ..from uninfected Biomphalaria glabrata, were used to screen a cDNA library prepared from adult Schistosoma mansoni. Of 1.8 x 10(5) recombinants screened, 34 clones were specifically immunoreactive with the antisera...

More Information

Publications112 found, 100 shown here

  1. Rossi A, Pica Mattoccia L, Cioli D, Klinkert M. Rapamycin insensitivity in Schistosoma mansoni is not due to FKBP12 functionality. Mol Biochem Parasitol. 2002;125:1-9 pubmed
    ..In this study, we found the helminth parasite Schistosoma mansoni to be insensitive to the drug. In order to elucidate the mechanism underlying RAPA resistance, the S...
  2. Salter J, Choe Y, Albrecht H, Franklin C, Lim K, Craik C, et al. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J Biol Chem. 2002;277:24618-24 pubmed
    ..Two of the five genes identified in Schistosoma mansoni account for over 90% of the activity and protein released...
  3. Kim E, Day T, Bennett J, Pax R. Cloning and functional expression of a Shaker-related voltage-gated potassium channel gene from Schistosoma mansoni (Trematoda: Digenea). Parasitology. 1995;110 ( Pt 2):171-80 pubmed
    ..1) encoding a Shaker-related K+ channel from an adult cDNA library of the human parasitic trematode Schistosoma mansoni. The deduced amino acid sequence (512 aa, 56...
  4. Ressurrei o M, Rollinson D, Emery A, Walker A. A role for p38 mitogen-activated protein kinase in early post-embryonic development of Schistosoma mansoni. Mol Biochem Parasitol. 2011;180:51-5 pubmed publisher
    The importance of p38 mitogen-activated protein kinase (p38 MAPK) to Schistosoma mansoni miracidium to mother-sporocyst development was investigated...
  5. Tran M, Freitas T, Cooper L, Gaze S, Gatton M, Jones M, et al. Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover. PLoS Pathog. 2010;6:e1000840 pubmed publisher
    ..These results imply that tetraspanins play important structural roles impacting tegument development, maturation or stability. ..
  6. Boumis G, Angelucci F, Bellelli A, Brunori M, Dimastrogiovanni D, Miele A. Structural and functional characterization of Schistosoma mansoni Thioredoxin. Protein Sci. 2011;20:1069-76 pubmed publisher
    ..of all the proteins involved in this pathway, we describe hereby the high-resolution crystal structure of Schistosoma mansoni Thioredoxin (SmTrx) in three states, namely: the wild-type oxidized adult enzyme and the oxidized and ..
  7. Francis P, Bickle Q. Cloning of a 21.7-kDa vaccine-dominant antigen gene of Schistosoma mansoni reveals an EF hand-like motif. Mol Biochem Parasitol. 1992;50:215-24 pubmed
    Several cDNA clones encoding a 21.7-kDa antigen (Sm21.7) were detected from a Schistosoma mansoni sporocyst cDNA expression library using irradiated cercaria-vaccinated rabbit serum...
  8. Dietzel J, Hirzmann J, Preis D, Symmons P, Kunz W. Ferritins of Schistosoma mansoni: sequence comparison and expression in female and male worms. Mol Biochem Parasitol. 1992;50:245-54 pubmed
    Recombinant clones of Schistosoma mansoni cDNA libraries containing the complete coding regions of 2 different ferritin subunits have been isolated and sequenced...
  9. Moser D, Tendler M, Griffiths G, Klinkert M. A 14-kDa Schistosoma mansoni polypeptide is homologous to a gene family of fatty acid binding proteins. J Biol Chem. 1991;266:8447-54 pubmed
    The complete nucleotide sequence encoding a Schistosoma mansoni protein termed Sm14 was determined from cDNA clones propagated in bacteriophage lambda gt11 in Escherichia coli. The 14...
  10. Smyth D, McManus D, Smout M, Laha T, Zhang W, Loukas A. Isolation of cDNAs encoding secreted and transmembrane proteins from Schistosoma mansoni by a signal sequence trap method. Infect Immun. 2003;71:2548-54 pubmed
    ..secreted and surface proteins with N-terminal signal peptides, so we constructed a randomly primed adult Schistosoma mansoni cDNA library fused to a signalless reporter gene encoding placental alkaline phosphatase...
  11. Gnanasekar M, Salunkhe A, Mallia A, He Y, Kalyanasundaram R. Praziquantel affects the regulatory myosin light chain of Schistosoma mansoni. Antimicrob Agents Chemother. 2009;53:1054-60 pubmed publisher
    ..To begin to understand where PZQ acts, in this study we expressed the cDNA library of Schistosoma mansoni on the surface of T7 bacteriophages and screened this library with labeled PZQ...
  12. Dvorak J, Mashiyama S, Sajid M, Braschi S, Delcroix M, Schneider E, et al. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2009;3:e449 pubmed publisher
    ..The visualization of network inter-relationships among cathepsins L suggests that these enzymes are suitable 'marker sequences' for inclusion in future phylogenetic analyses. ..
  13. Kasinathan R, Morgan W, Greenberg R. Schistosoma mansoni express higher levels of multidrug resistance-associated protein 1 (SmMRP1) in juvenile worms and in response to praziquantel. Mol Biochem Parasitol. 2010;173:25-31 pubmed publisher
    ..Here, we examine the relationship between PZQ and SmMRP1, a Schistosoma mansoni homolog of mammalian MRP1...
  14. Williams D, Pierce R, Cookson E, Capron A. Molecular cloning and sequencing of glutathione peroxidase from Schistosoma mansoni. Mol Biochem Parasitol. 1992;52:127-30 pubmed
  15. DeMarco R, Kowaltowski A, Machado A, Soares M, Gargioni C, Kawano T, et al. Saci-1, -2, and -3 and Perere, four novel retrotransposons with high transcriptional activities from the human parasite Schistosoma mansoni. J Virol. 2004;78:2967-78 pubmed
    Using the data set of 180,000 expressed sequence tags (ESTs) of the blood fluke Schistosoma mansoni generated recently by our group, we identified three novel long-terminal-repeat (LTR)- and one novel non-LTR-expressed retrotransposon, ..
  16. Chalmers I, McArdle A, Coulson R, Wagner M, Schmid R, Hirai H, et al. Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family. BMC Genomics. 2008;9:89 pubmed publisher
    ..We report the first description of an SCP/TAPS gene family (Schistosoma mansoni venom allergen-like (SmVALs)) in the medically important Platyhelminthes (class Trematoda) and describe ..
  17. Pinho J, Cardoso F, Lopes D, Pinheiro C, Caliari M, Oliveira F, et al. Immunization with SmIg, a novel tegument protein from Schistosoma mansoni, fails to induce protection in mice but reduces liver pathology. Parasitology. 2010;137:1079-88 pubmed publisher
    ..Herein, we have isolated a cDNA clone encoding for the Schistosoma mansoni SmIg and its recombinant protein was tested as a potential vaccine candidate...
  18. Farias L, Tararam C, Miyasato P, Nishiyama M, Oliveira K, Kawano T, et al. Screening the Schistosoma mansoni transcriptome for genes differentially expressed in the schistosomulum stage in search for vaccine candidates. Parasitol Res. 2011;108:123-35 pubmed publisher
    ..attempt to identify genes up-regulated in the schistosomulum stage in relation to cercaria, we explored the Schistosoma mansoni transcriptome by looking at the relative frequency of reads in EST libraries from both stages...
  19. Hu R, Wu W, Niles E, LoVerde P. Isolation and characterization of Schistosoma mansoni constitutive androstane receptor. Mol Biochem Parasitol. 2006;148:31-43 pubmed publisher
    Full length cDNA clones encoding a Schistosoma mansoni homologue of vertebrate CAR/PXR/VDR group nuclear receptor, termed SmCAR were isolated from screening a S. mansoni adult worm cDNA library...
  20. de Oliveira F, de Abreu da Silva I, Rumjanek F, Dias Neto E, Guimar es P, Verjovski Almeida S, et al. Cloning the genes and DNA binding properties of High Mobility Group B1 (HMGB1) proteins from the human blood flukes Schistosoma mansoni and Schistosoma japonicum. Gene. 2006;377:33-45 pubmed publisher
    The parasitic helminth Schistosoma mansoni contains three HMGB proteins, HMGB1, HMGB2 and HMGB3, of primary amino acid sequences highly similar to vertebrate proteins...
  21. Xu H, Miller S, van Keulen H, Wawrzynski M, Rekosh D, Loverde P. Schistosoma mansoni tropomyosin: cDNA characterization, sequence, expression, and gene product localization. Exp Parasitol. 1989;69:373-92 pubmed
    We have defined the polypeptide pattern of 3-hr Schistosoma mansoni schistosomula on nonequilibrium two-dimensional gels (NEPHGE). An acidic group of polypeptides with a molecular weight of about 40 kDa and a pI value of around 5...
  22. Davis R, Hardwick C, Tavernier P, Hodgson S, Singh H. RNA trans-splicing in flatworms. Analysis of trans-spliced mRNAs and genes in the human parasite, Schistosoma mansoni. J Biol Chem. 1995;270:21813-9 pubmed
    Characteristics of trans-splicing in Schistosoma mansoni were examined to explore the significance and determinants of spliced leader (SL) addition in flatworms. Only a small subset of mRNAs acquire the SL...
  23. Alger H, Williams D. The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase. Mol Biochem Parasitol. 2002;121:129-39 pubmed
    b>Schistosoma mansoni, a causative agent of schistosomiasis, is a major cause of human morbidity in tropical countries...
  24. Oke T, Moskovitz J, Williams D. Characterization of the methionine sulfoxide reductases of Schistosoma mansoni. J Parasitol. 2009;95:1421-8 pubmed publisher
    ..This is the first description of MsrB proteins from a parasite...
  25. Simurda M, van Keulen H, Rekosh D, Loverde P. Schistosoma mansoni: identification and analysis of an mRNA and a gene encoding superoxide dismutase (Cu/Zn). Exp Parasitol. 1988;67:73-84 pubmed
    The sequence of an mRNA encoding superoxide dismutase (EC 1.15.1.1) of Schistosoma mansoni has been determined...
  26. Skelly P, Kim J, Cunningham J, Shoemaker C. Cloning, characterization, and functional expression of cDNAs encoding glucose transporter proteins from the human parasite Schistosoma mansoni. J Biol Chem. 1994;269:4247-53 pubmed
    The blood-dwelling adult form of the parasitic worm, Schistosoma mansoni, consumes prodigious quantities of host glucose following its transport across the tegument...
  27. Hoffmann K, Strand M. Molecular identification of a Schistosoma mansoni tegumental protein with similarity to cytoplasmic dynein light chains. J Biol Chem. 1996;271:26117-23 pubmed
    The tegument of Schistosoma mansoni contains a number of proteins that presumably function in its maintenance and/or repair against damage incurred from host-mediated humoral immune responses...
  28. Davis R, Hodgson S. Gene linkage and steady state RNAs suggest trans-splicing may be associated with a polycistronic transcript in Schistosoma mansoni. Mol Biochem Parasitol. 1997;89:25-39 pubmed
    ..and characterization of a closely linked gene upstream from the trans-spliced enolase gene in the flatworm Schistosoma mansoni. This gene produces a non-trans-spliced mRNA encoding a ubiquinol binding protein, UbCRBP, that is a ..
  29. Milhon J, Albert T, Vande Waa E, O Leary K, Jackson R, Kessler M, et al. SmMAK16, the Schistosoma mansoni homologue of MAK16 from yeast, targets protein transport to the nucleolus. Mol Biochem Parasitol. 2000;108:225-36 pubmed
    The SmMAK16 gene from Schistosoma mansoni was cloned by chance when an adult worm cDNA library was probed with antiserum to affinity-purified S. mansoni GSH S-transferases...
  30. Alger H, Sayed A, Stadecker M, Williams D. Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin. Int J Parasitol. 2002;32:1285-92 pubmed
    ..Here, we report the identification and characterisation of a thioredoxin from Schistosoma mansoni. The predicted protein has similarity to previously characterised thioredoxins including conservation of ..
  31. Wu W, Tak E, LoVerde P. Schistosoma mansoni: SmE78, a nuclear receptor orthologue of Drosophila ecdysone-induced protein 78. Exp Parasitol. 2008;119:313-8 pubmed publisher
    ..We isolated a cDNA of Drosophila E78 orthologue from the Platyhelminth Schistosoma mansoni (SmE78). It is the first E78 orthologue known outside of the molting animals--the Ecdysozoa...
  32. Faghiri Z, Skelly P. The role of tegumental aquaporin from the human parasitic worm, Schistosoma mansoni, in osmoregulation and drug uptake. FASEB J. 2009;23:2780-9 pubmed publisher
    ..These experiments reveal a heretofore unrecognized role of the schistosome tegument in controlling water and drug movement into the parasites and highlight the importance of the tegument in parasite osmoregulation and drug uptake. ..
  33. Beckmann S, Buro C, Dissous C, Hirzmann J, Grevelding C. The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis. PLoS Pathog. 2010;6:e1000769 pubmed publisher
    The signal transduction protein SmTK4 from Schistosoma mansoni belongs to the family of Syk kinases. In vertebrates, Syk kinases are known to play specialized roles in signaling pathways in cells of the hematopoietic system...
  34. Faghiri Z, Camargo S, Huggel K, Forster I, Ndegwa D, Verrey F, et al. The tegument of the human parasitic worm Schistosoma mansoni as an excretory organ: the surface aquaporin SmAQP is a lactate transporter. PLoS ONE. 2010;5:e10451 pubmed publisher
    ..These findings extend the proposed functions of the schistosome tegument beyond its known capacity as an organ of nutrient uptake to include a role in metabolic waste excretion...
  35. Larsen M, Fontana A, Magalh es L, Rodrigues V, Mortensen O. A catecholamine transporter from the human parasite Schistosoma mansoni with low affinity for psychostimulants. Mol Biochem Parasitol. 2011;177:35-41 pubmed publisher
    The trematode Schistosoma mansoni is the primary cause of schistosomiasis, a devastating neglected tropical disease that affects 200 million individuals...
  36. Fitzsimmons C, Jones F, Stearn A, Chalmers I, Hoffmann K, Wawrzyniak J, et al. The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses. PLoS Negl Trop Dis. 2012;6:e1593 pubmed publisher
    A human IgE response to Sm22.6 (a dominant IgE target in Schistosoma mansoni) is associated with the development of partial immunity...
  37. Dufour V, Beech R, Wever C, Dent J, Geary T. Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni. PLoS Pathog. 2013;9:e1003586 pubmed publisher
    ..In this study, we characterized the anion-selective, non-acetylcholine-gated Cys-loop LGICs from Schistosoma mansoni. Full-length cDNAs were obtained for SmGluCl-1 (Smp_096480), SmGluCl-2 (Smp_015630) and SmGluCl-3 (..
  38. El Sherbeini M, Ramadan N, Bostian K, Knopf P. Cloning and sequence analysis of the Schistosoma mansoni membrane glycoprotein antigen gene GP22. Mol Biochem Parasitol. 1991;49:83-98 pubmed
    A family of Schistosoma mansoni proteins (18-22 kDa, pI 5.3-5.8) are biosynthesized in juvenile worms and immunoprecipitated by antibodies uniquely present in protective Fischer rat antiserum...
  39. Beall M, McGonigle S, Pearce E. Functional conservation of Schistosoma mansoni Smads in TGF-beta signaling. Mol Biochem Parasitol. 2000;111:131-42 pubmed
    To begin to understand the molecular basis of communication between the parasite Schistosoma mansoni and its mammalian host, we are studying the signaling pathway downstream of S...
  40. McGonigle S, Loschiavo M, Pearce E. 14-3-3 proteins in Schistosoma mansoni; identification of a second epsilon isoform. Int J Parasitol. 2002;32:685-93 pubmed
    A new member of the 14-3-3 protein family in Schistosoma mansoni has been identified. Sequence analysis demonstrated that this protein is a member of the epsilon sub-group and is the orthologue of Schistosoma japonicum 14-3-3epsilon...
  41. Capowski E, Tracy J. Ribosomal RNA processing and the role of SmMAK16 in ribosome biogenesis in Schistosoma mansoni. Mol Biochem Parasitol. 2003;132:67-74 pubmed
    ..While the physical structure and sequence of ribosomal RNA (rRNA) in the trematode Schistosoma mansoni have been described, the process of cleavage, modification and assembly of the mature ribonucleoprotein ..
  42. Humphries J, Kimber M, Barton Y, Hsu W, Marks N, Greer B, et al. Structure and bioactivity of neuropeptide F from the human parasites Schistosoma mansoni and Schistosoma japonicum. J Biol Chem. 2004;279:39880-5 pubmed
    The blood flukes Schistosoma mansoni and Schistosoma japonicum inflict immense suffering as agents of human schistosomiasis...
  43. Oger F, Dubois F, Caby S, No l C, Cornette J, Bertin B, et al. The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni. Biochem Biophys Res Commun. 2008;377:1079-84 pubmed publisher
    ..To investigate the conservation of these enzymes in the platyhelminth parasite Schistosoma mansoni, we cloned and characterized three class I HDACs, orthologues of mammalian HDAC1, 3 and 8, and confirmed ..
  44. Jeffs S, Hagan P, Allen R, Correa Oliveira R, Smithers S, Simpson A. Molecular cloning and characterisation of the 22-kilodalton adult Schistosoma mansoni antigen recognised by antibodies from mice protectively vaccinated with isolated tegumental surface membranes. Mol Biochem Parasitol. 1991;46:159-67 pubmed
    A cDNA clone from an adult Schistosoma mansoni lambda gt11 expression library (A12) encoding an antigenic polypeptide of 22 kDa is described...
  45. Abath F, Xavier E, Allen R, Gomes Y, Lucena Silva N, Baliza M, et al. Characterization of Sm13, a tegumental antigen of Schistosoma mansoni. Parasitol Res. 2000;86:745-52 pubmed
    Sm13, a 13-kDa Schistosoma mansoni tegumental antigen, is one of the principal polypeptides recognized by antibodies from mice protectively vaccinated with adult-worm tegumental membranes...
  46. Caffrey C, Salter J, Lucas K, Khiem D, Hsieh I, Lim K, et al. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Mol Biochem Parasitol. 2002;121:49-61 pubmed
    ..By immunohistochemistry, SmCB2 was localized in the tegumental tubercles and parenchyma of males with less product being visualized in the parenchyma of females. The enzyme may be lysosomal and function at the host parasite-interface. ..
  47. Osman A, Niles E, LoVerde P. Expression of functional Schistosoma mansoni Smad4: role in Erk-mediated transforming growth factor beta (TGF-beta) down-regulation. J Biol Chem. 2004;279:6474-86 pubmed
    ..b>Schistosoma mansoni receptor-regulated Smad1 and SmSmad2 were previously identified and shown to act in TGF-beta signaling...
  48. Morales F, Furtado D, Rumjanek F. The N-terminus moiety of the cystatin SmCys from Schistosoma mansoni regulates its inhibitory activity in vitro and in vivo. Mol Biochem Parasitol. 2004;134:65-73 pubmed
    The complete sequence of SmCys, a cystatin expressed by Schistosoma mansoni, was obtained...
  49. Mansure J, Furtado D, de Oliveira F, Rumjanek F, Franco G, Fantappi M. Cloning of a protein arginine methyltransferase PRMT1 homologue from Schistosoma mansoni: evidence for roles in nuclear receptor signaling and RNA metabolism. Biochem Biophys Res Commun. 2005;335:1163-72 pubmed publisher
    ..We cloned a cDNA encoding a protein arginine methyltransferase in Schistosoma mansoni (SmPRMT1). SmPRMT1 is highly homologous to the vertebrate PRMT1 enzyme...
  50. Carneiro V, de Moraes Maciel R, de Abreu da Silva I, da Costa R, Paiva C, Bozza M, et al. The extracellular release of Schistosoma mansoni HMGB1 nuclear protein is mediated by acetylation. Biochem Biophys Res Commun. 2009;390:1245-9 pubmed publisher
    b>Schistosoma mansoni HMGB1 (SmHMGB1) was revealed to be a substrate for the parasite histone acetyltransferases SmGCN5 and SmCBP1...
  51. Taman A, Ribeiro P. Glutamate-mediated signaling in Schistosoma mansoni: a novel glutamate receptor is expressed in neurons and the female reproductive tract. Mol Biochem Parasitol. 2011;176:42-50 pubmed publisher
    ..Earlier studies have shown that glutamate stimulates neuromuscular activity in the bloodfluke, Schistosoma mansoni, but its mode of action is unknown. Here we describe a novel glutamate receptor in S...
  52. Protasio A, Tsai I, Babbage A, Nichol S, Hunt M, Aslett M, et al. A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2012;6:e1455 pubmed publisher
    ..Amongst the human-infective species, Schistosoma mansoni is also the most commonly used in the laboratory and here we present the systematic improvement of its ..
  53. Zeraik A, Pereira H, Santos Y, Brand o Neto J, Spoerner M, Santos M, et al. Crystal structure of a Schistosoma mansoni septin reveals the phenomenon of strand slippage in septins dependent on the nature of the bound nucleotide. J Biol Chem. 2014;289:7799-811 pubmed publisher
    ..Here, we present two crystal structures of the GTPase domain of a Schistosoma mansoni septin (SmSEPT10), one bound to GDP and the other to GTP...
  54. Horn M, Fajtov P, Rojo Arreola L, Ulrychov L, Barto ov Sojkov P, Franta Z, et al. Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PLoS Negl Trop Dis. 2014;8:e2766 pubmed publisher
    ..A framework is now in place to guide the characterization of individual proteases, their stage-specific expression and their contributions to parasitism, in particular, their possible modulation of host physiology...
  55. Webster P, Seta K, Chung S, Mansour T. A cDNA encoding an alpha-tubulin from Schistosoma mansoni. Mol Biochem Parasitol. 1992;51:169-70 pubmed
  56. Reis M, Kuhns J, Blanton R, Davis A. Localization and pattern of expression of a female specific mRNA in Schistosoma mansoni. Mol Biochem Parasitol. 1989;32:113-9 pubmed
    To understand mechanisms involved in sex-specific gene expression in Schistosoma mansoni, a cDNA (fs800) was isolated that hybridized to an 800 nucleotide mRNA present in high levels only in mature female worms...
  57. Vermeire J, Osman A, LoVerde P, Williams D. Characterisation of a Rho homologue of Schistosoma mansoni. Int J Parasitol. 2003;33:721-31 pubmed
    The development and survival of the helminth parasite, Schistosoma mansoni, is dependent on its ability to interpret signals from its environment. Currently, little is known about signal transduction in schistosomes...
  58. DeMarco R, Kowaltowski A, Mortara R, Verjovski Almeida S. Molecular characterization and immunolocalization of Schistosoma mansoni ATP-diphosphohydrolase. Biochem Biophys Res Commun. 2003;307:831-8 pubmed
    b>Schistosoma mansoni, a human parasite that constitutes a major health problem in developing countries, escapes from host defenses and survives in the human bloodstream. Here, we report the cloning of a S...
  59. Fantappi M, Osman A, Ericsson C, Niles E, LoVerde P. Cloning of Schistosoma mansoni Seven in Absentia (SmSINA)(+) homologue cDNA, a gene involved in ubiquitination of SmRXR1 and SmRXR2. Mol Biochem Parasitol. 2003;131:45-54 pubmed
    ..Using the Schistosoma mansoni nuclear receptor SmRXR2 as bait in a yeast two-hybrid system, we identified a DNA fragment that encodes ..
  60. Sajid M, McKerrow J, Hansell E, Mathieu M, Lucas K, Hsieh I, et al. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol. 2003;131:65-75 pubmed
    Peptidases are essential for the establishment and survival of the medically important parasite, Schistosoma mansoni. This helminth expresses a number of gut-associated peptidases that degrade host blood proteins, including hemoglobin, ..
  61. Sayed A, Williams D. Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni. J Biol Chem. 2004;279:26159-66 pubmed publisher
    ..peroxiredoxin proteins were identified in the expressed sequence tag data base of the helminth parasite Schistosoma mansoni, a causative agent of schistosomiasis...
  62. Gnanasekar M, Velusamy R, He Y, Ramaswamy K. Cloning and characterization of a high mobility group box 1 (HMGB1) homologue protein from Schistosoma mansoni. Mol Biochem Parasitol. 2006;145:137-46 pubmed publisher
    ..of high mobility group box chromatin protein (HMGB) 1 was identified and cloned from human parasites, Schistosoma mansoni and S. haematobium...
  63. Pacifico L, Fonseca C, Chiari L, Oliveira S. Immunization with Schistosoma mansoni 22.6 kDa antigen induces partial protection against experimental infection in a recombinant protein form but not as DNA vaccine. Immunobiology. 2006;211:97-104 pubmed
    ..In this study we isolated a cDNA clone encoding the Schistosoma mansoni lung-stage Sm22.6 protein, which is 100% and 79% identical with the 22...
  64. Silva C, Silva S, Pereira J nior O, Cabral F, Costa Cruz J, Rodrigues V. Schistosoma mansoni: gene expression of the nucleotide excision repair factor 2 (NEF2) during the parasite life cycle, and in adult worms after exposure to different DNA-damaging agents. Acta Trop. 2007;104:52-62 pubmed publisher
    ..b>Schistosoma mansoni has a complex life cycle, being exposed to a subset of DNA-damaging agents, such as those present in the ..
  65. El Shehabi F, Ribeiro P. Histamine signalling in Schistosoma mansoni: immunolocalisation and characterisation of a new histamine-responsive receptor (SmGPR-2). Int J Parasitol. 2010;40:1395-406 pubmed publisher
    In parasitic platyhelminthes, including Schistosoma mansoni, biogenic amines play several important roles in the control of motility, metabolism and reproduction. A bioinformatics analysis of the S...
  66. Perrin C, Lepesant J, Roger E, Duval D, Fneich S, Thuillier V, et al. Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host. PLoS Pathog. 2013;9:e1003571 pubmed publisher
    The digenetic trematode Schistosoma mansoni is a human parasite that uses the mollusc Biomphalaria glabrata as intermediate host. Specific S. mansoni strains can infect efficiently only certain B...
  67. de Carvalho B, Coutinho Domingues A, de Almeida Lopes E, Brandão S. Increased Hepatic Arterial Blood Flow Measured by Hepatic Perfusion Index in Hepatosplenic Schistosomiasis: New Concepts for an Old Disease. Dig Dis Sci. 2016;61:2118-26 pubmed publisher
    Portal vein obstructive lesions associated with hypertrophy of the hepatic artery territory are observed in Schistosoma mansoni schistosomiasis...
  68. Downs J, de Dood C, Dee H, McGeehan M, Khan H, Marenga A, et al. Schistosomiasis and Human Immunodeficiency Virus in Men in Tanzania. Am J Trop Med Hyg. 2017;96:856-862 pubmed publisher
    ..6-2.5] (P = 0.53) among men with any schistosome infection (Schistosoma haematobium or Schistosoma mansoni), and it was 1.4 [0.6-3.3] (P = 0.43) among men with S. haematobium infection...
  69. Lingscheid T, Kurth F, Clerinx J, Marocco S, Treviño B, Schunk M, et al. Schistosomiasis in European Travelers and Migrants: Analysis of 14 Years TropNet Surveillance Data. Am J Trop Med Hyg. 2017;97:567-574 pubmed publisher
    ..On species level, Schistosoma mansoni was identified in 570 (39%) and Schistosoma haematobium in 318 (22%) cases; 57...
  70. Wang Q, Da dara A, Skelly P. The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin. Sci Rep. 2017;7:12912 pubmed publisher
    ..reveals that two proteases belonging to the calpain family (SmCalp1 and SmCalp2) are expressed in the Schistosoma mansoni tegument...
  71. Buddenborg S, Bu L, Zhang S, Schilkey F, Mkoji G, Loker E. Transcriptomic responses of Biomphalaria pfeifferi to Schistosoma mansoni: Investigation of a neglected African snail that supports more S. mansoni transmission than any other snail species. PLoS Negl Trop Dis. 2017;11:e0005984 pubmed publisher
    Biomphalaria pfeifferi is highly compatible with the widespread human-infecting blood fluke Schistosoma mansoni and transmits more cases of this parasite to people than any other snail species. For these reasons, B...
  72. Munisi D, Buza J, Mpolya E, Angelo T, Kinung hi S. The Efficacy of Single-Dose versus Double-Dose Praziquantel Treatments on Schistosoma mansoni Infections: Its Implication on Undernutrition and Anaemia among Primary Schoolchildren in Two On-Shore Communities, Northwestern Tanzania. Biomed Res Int. 2017;2017:7035025 pubmed publisher
    ..05). To achieve reduction of transmission intensity and disease control in highly endemic areas, repeated treatments alone may not be sufficient. This trial was registered with PACTR201601001416338...
  73. Silva H, Siqueira W, Sá J, Silva L, Martins M, Aires A, et al. Laboratory assessment of divaricatic acid against Biomphalaria glabrata and Schistosoma mansoni cercariae. Acta Trop. 2018;178:97-102 pubmed publisher
    ..divaricatic acid was evaluated, targeting the mollusc Biomphalaria glabrata and cercariae of the helminth Schistosoma mansoni. In addition, the environmental toxicity of divaricatic acid was assessed by bioassay using the ..
  74. Nkurunungi G, Kabagenyi J, Nampijja M, Sanya R, Walusimbi B, Nassuuna J, et al. Schistosoma mansoni-specific immune responses and allergy in Uganda. Parasite Immunol. 2017;: pubmed publisher
    ..In the Schistosoma mansoni (Sm)-endemic Lake Victoria islands (Uganda), we recently observed positive helminth-allergy associations, ..
  75. Berhe N, Myrvang B, Gundersen S. Gastro-intestinal symptoms associated with intense Schistosoma mansoni infection affect class-attentiveness of schoolchildren in Ethiopia. Acta Trop. 2009;110:52-6 pubmed
    ..To assess effect of subtle morbidities related to Schistosomiasis mansoni on class-attentiveness of schoolchildren...
  76. Vannella K, Ramalingam T, Borthwick L, Barron L, Hart K, Thompson R, et al. Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis. Sci Transl Med. 2016;8:337ra65 pubmed publisher
    ..In a schistosome lung granuloma model or during chronic Schistosoma mansoni infection in the liver, individual ablation of TSLP, IL-25, or IL-33/ST2 had no impact on the development ..
  77. Campos J, Neves L, de Paiva N, de Oliveira E Castro R, Casé A, Carneiro C, et al. Understanding global changes of the liver proteome during murine schistosomiasis using a label-free shotgun approach. J Proteomics. 2017;151:193-203 pubmed publisher
    ..In this study, we infected Balb/c mice with Schistosoma mansoni and analysed global changes in the proteomic profile of soluble liver proteins...
  78. Nyandwi E, Veldkamp T, Osei F, Amer S. Spatio-temporal dynamics of schistosomiasis in Rwanda between 2001 and 2012: impact of the national Neglected Tropical Disease control programme. Geospat Health. 2017;12:514 pubmed publisher
    ..Incidence data of Schistosoma mansoni infection at 367 health facilities were obtained for the period 2001-2012...
  79. Ibrahim A, Abdalla A. Impact of Moringa oleifera seed aqueous extract on some biological, biochemical, and histological aspects of Biomphalaria alexandrina snails. Environ Sci Pollut Res Int. 2017;24:28072-28078 pubmed publisher
    ..It is a snail-borne trematode infection, and Biomphalaria alexandrina snails are the intermediate host of Schistosoma mansoni in Egypt...
  80. Molehin A, Sennoune S, Zhang W, Rojo J, Siddiqui A, Herrera K, et al. Cross-species prophylactic efficacy of Sm-p80-based vaccine and intracellular localization of Sm-p80/Sm-p80 ortholog proteins during development in Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium. Parasitol Res. 2017;116:3175-3188 pubmed publisher
    ..b>Schistosoma mansoni large subunit of calpain (Sm-p80)-based vaccine formulations have shown remarkable efficacy in protecting ..
  81. Tetreau G, Pinaud S, Portet A, Galinier R, Gourbal B, Duval D. Specific Pathogen Recognition by Multiple Innate Immune Sensors in an Invertebrate. Front Immunol. 2017;8:1249 pubmed publisher
    ..coli; yeast, Saccharomyces cerevisiae; and metazoan parasites, Echinostoma caproni or Schistosoma mansoni) were exposed to hemocyte-free hemolymph from the gastropod Biomphalaria glabrata...
  82. Babes R, Selescu T, Domocos D, Babes A. The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel. Toxicol Appl Pharmacol. 2017;336:55-65 pubmed publisher
    ..anthelminthic drug for the treatment of schistosomiasis, an infectious disease caused by the platyhelminth Schistosoma mansoni. While praziquantel is known to trigger calcium influx into schisostomes, followed by spastic paralysis of ..
  83. Karanja D, Awino E, Wiegand R, Okoth E, Abudho B, Mwinzi P, et al. Cluster randomized trial comparing school-based mass drug administration schedules in areas of western Kenya with moderate initial prevalence of Schistosoma mansoni infections. PLoS Negl Trop Dis. 2017;11:e0006033 pubmed publisher
    ..We wished to evaluate whether annual MDA was more effective than less frequent treatments for reducing community-level prevalence and intensity of Schistosoma mansoni infections.
  84. Attia M, Soliman S, Khalf M. Hydrophilic nanosilica as a new larvicidal and molluscicidal agent for controlling of major infectious diseases in Egypt. Vet World. 2017;10:1046-1051 pubmed publisher
    ..in the eradication of the larvae and pupa of malaria and filariasis vector as well as vectors of rift-valley fever virus (Culex pipiens); Schistosoma mansoni vector and Biomphlaria alexandrina (snail and egg masses).
  85. Floudas A, Cluxton C, Fahel J, Khan A, Saunders S, Amu S, et al. Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A. PLoS Negl Trop Dis. 2017;11:e0006012 pubmed publisher
    The helminth Schistosoma mansoni modulates the infected host's immune system to facilitate its own survival, by producing excretory/secretory molecules that interact with a variety of the host's cell types including those of the immune ..
  86. Mazigo H, Nuwaha F, Dunne D, Kaatano G, Angelo T, Kepha S, et al. Schistosoma mansoni Infection and Its Related Morbidity among Adults Living in Selected Villages of Mara Region, North-Western Tanzania: A Cross-Sectional Exploratory Study. Korean J Parasitol. 2017;55:533-540 pubmed publisher
    b>Schistosoma mansoni is highly endemic in Tanzania and affects all age groups at different degrees. However, its control approach does not include adult individuals who are equally at risk and infected...
  87. Mahmoud M, Ibrahim A, Badawy A, Abdelmoniem N. Effect of phenyl vinyl sulphone cysteine protease inhibitor on Schistosoma mansoni: in vitro and in vivo experimental studies. J Parasit Dis. 2017;41:1049-1058 pubmed publisher
    ..These results suggest that PVS can be a promising chemotherapeutic agent in Schistosoma mansoni infection.
  88. Nakamura I, Yagi K, Kumagai T, Ohta N. Positive fecal occult blood test as a diagnostic cue for Schistosoma mansoni infection in a developed country. IDCases. 2017;10:108-109 pubmed publisher
    ..As this tropical disease is rarely present in developed countries, it may be under-diagnosed. Schistosomiasis should be included in the differential diagnosis of patients with positive FOB tests...
  89. Sakari S, Mbugua A, Mkoji G. Prevalence of Soil-Transmitted Helminthiases and Schistosomiasis in Preschool Age Children in Mwea Division, Kirinyaga South District, Kirinyaga County, and Their Potential Effect on Physical Growth. J Trop Med. 2017;2017:1013802 pubmed publisher
    ..6%) and Enterobius vermicularis (<1%). Schistosoma mansoni occurred at a prevalence of 5.5%. Interestingly, the protozoan, Giardia lamblia (prevalence, 14...
  90. Silva J, Pinheiro M, Sousa M, Gomes V, Castro I, Ramos A, et al. Detection of schistosomiasis in an area directly affected by the São Francisco River large-scale water transposition project in the Northeast of Brazil. Rev Soc Bras Med Trop. 2017;50:658-665 pubmed publisher
    ..We aimed to determine the presence of Schistosoma mansoni infections in schoolchildren (aged 7-14 years) and workers from the construction site in an area under the ..
  91. Martínez Sernández V, Perteguer M, Mezo M, González Warleta M, Garate T, Valero M, et al. Fasciola spp: Mapping of the MF6 epitope and antigenic analysis of the MF6p/HDM family of heme-binding proteins. PLoS ONE. 2017;12:e0188520 pubmed publisher
    ..westermani orthologs. On the contrary, mAb MF6 showed no reactivity against Dicrocoelium dendriticum and Schistosoma mansoni. The study of the recognition of peptides covering different regions of MF6p/FhHDM-1 by sera from immunized ..
  92. Mansour T, Habib M, Rodríguez L, Vázquez A, Alers J, Ghezzi A, et al. Central nervous system transcriptome of Biomphalaria alexandrina, an intermediate host for schistosomiasis. BMC Res Notes. 2017;10:729 pubmed publisher
    ..from the central nervous system (CNS) of Biomphalaria alexandrina, the major intermediate host for Schistosoma mansoni in Egypt...