Streptomyces coelicolor A3(2)

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Alias:

Top Publications

  1. doi Two overlapping antiparallel genes encoding the iron regulator DmdR1 and the Adm proteins control siderophore [correction of sedephore] and antibiotic biosynthesis in Streptomyces coelicolor A3(2)
    Sedef Tunca
    Institute of Biotechnology of León, INBIOTEC, Parque Cientifico de Leon, Avenida Real no 1, Spain
    FEBS J 276:4814-27. 2009
  2. ncbi The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces
    M A Fernandez-Moreno
    Centro Nacional de Biotecnologia, Madrid, Spain
    Cell 66:769-80. 1991
  3. ncbi Growth and viability of Streptomyces coelicolor mutant for the cell division gene ftsZ
    J R McCormick
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138
    Mol Microbiol 14:243-54. 1994
  4. ncbi afsR2: a previously undetected gene encoding a 63-amino-acid protein that stimulates antibiotic production in Streptomyces lividans
    M Vogtli
    Department of Genetics, Stanford University School of Medicine, California 94305
    Mol Microbiol 14:643-53. 1994
  5. pmc A novel nickel-containing superoxide dismutase from Streptomyces spp
    H D Youn
    Department of Microbiology, College of Natural Sciences, Seoul National University, Republic of Korea
    Biochem J 318:889-96. 1996
  6. ncbi Differential expression of superoxide dismutases containing Ni and Fe/Zn in Streptomyces coelicolor
    F J Kim
    Department of Microbiology, College of Natural Sciences, Seoul National University, Korea
    Eur J Biochem 241:178-85. 1996
  7. ncbi The structure of the potassium channel: molecular basis of K+ conduction and selectivity
    D A Doyle
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:69-77. 1998
  8. ncbi A response-regulator-like activator of antibiotic synthesis from Streptomyces coelicolor A3(2) with an amino-terminal domain that lacks a phosphorylation pocket
    E P Guthrie
    John Innes Centre, Colney, Norwich, UK
    Microbiology 144:727-38. 1998
  9. ncbi Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis
    H Onaka
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    Mol Microbiol 28:743-53. 1998
  10. ncbi A developmentally regulated gene encoding a repressor-like protein is essential for sporulation in Streptomyces coelicolor A3(2)
    N J Ryding
    John Innes Centre, Norwich Research Park, UK
    Mol Microbiol 29:343-57. 1998

Research Grants

Patents

  1. CYANOBACTERIA HAVING IMPROVED PHOTOSYNTHETIC ACTIVITY
  2. Agar-derived neoagarooligosaccharide complex for the prevention and treatment of obesity and/or diabetes comprising enzyme reaction products of beta agarase DagA and agar
  3. MODIFIED DIACYLGLYCEROL ACYLTRANSFERASE PROTEINS AND METHODS OF USE THEREOF
  4. A method for improving the material productivity of microorganisms and a kit for use in the method
  5. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
  6. Process for the production of a fine chemical
  7. Proteins associated with abiotic stress response and homologs
  8. RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES
  9. CONSTRUCTS FOR EXPRESSING HERBICIDE TOLERANCE GENES, RELATED PLANTS, AND RELATED TRAIT COMBINATIONS
  10. Site-specific genetic recombination method based on TG1 integrase

Detail Information

Publications221 found, 100 shown here

  1. doi Two overlapping antiparallel genes encoding the iron regulator DmdR1 and the Adm proteins control siderophore [correction of sedephore] and antibiotic biosynthesis in Streptomyces coelicolor A3(2)
    Sedef Tunca
    Institute of Biotechnology of León, INBIOTEC, Parque Cientifico de Leon, Avenida Real no 1, Spain
    FEBS J 276:4814-27. 2009
    ..The Adm protein seems to have a major effect on the control of secondary metabolism, and its formation is probably tightly controlled, as expected for a key regulator...
  2. ncbi The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces
    M A Fernandez-Moreno
    Centro Nacional de Biotecnologia, Madrid, Spain
    Cell 66:769-80. 1991
    ..We conclude that initiation of actinorhodin synthesis via the actII-ORF4 product, and the final step in production, antibiotic export, are twin targets via which bldA exerts developmental control of actinorhodin production...
  3. ncbi Growth and viability of Streptomyces coelicolor mutant for the cell division gene ftsZ
    J R McCormick
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138
    Mol Microbiol 14:243-54. 1994
    ....
  4. ncbi afsR2: a previously undetected gene encoding a 63-amino-acid protein that stimulates antibiotic production in Streptomyces lividans
    M Vogtli
    Department of Genetics, Stanford University School of Medicine, California 94305
    Mol Microbiol 14:643-53. 1994
    ..Analysis of the cloned afsR2 gene indicates that its activity is the result of the 63-amino-acid protein it specifies...
  5. pmc A novel nickel-containing superoxide dismutase from Streptomyces spp
    H D Youn
    Department of Microbiology, College of Natural Sciences, Seoul National University, Republic of Korea
    Biochem J 318:889-96. 1996
    ..The apoenzymes, lacking in nickel, had no ability to mediate the conversion of superoxide anion radical to hydrogen peroxide, strongly indicating that NiIII plays a main role in these enzymes...
  6. ncbi Differential expression of superoxide dismutases containing Ni and Fe/Zn in Streptomyces coelicolor
    F J Kim
    Department of Microbiology, College of Natural Sciences, Seoul National University, Korea
    Eur J Biochem 241:178-85. 1996
    ..The changes in SOD activities were positively correlated with the amount of each enzyme as determined by immunoblotting, suggesting that metals do not modulate the activity per se but the amount of each protein...
  7. ncbi The structure of the potassium channel: molecular basis of K+ conduction and selectivity
    D A Doyle
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:69-77. 1998
    ..The architecture of the pore establishes the physical principles underlying selective K+ conduction...
  8. ncbi A response-regulator-like activator of antibiotic synthesis from Streptomyces coelicolor A3(2) with an amino-terminal domain that lacks a phosphorylation pocket
    E P Guthrie
    John Innes Centre, Colney, Norwich, UK
    Microbiology 144:727-38. 1998
    ....
  9. ncbi Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis
    H Onaka
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    Mol Microbiol 28:743-53. 1998
    ..It is thus concluded that both cprA and cprB play regulatory roles in both secondary metabolism and morphogenesis in S. coelicolor A3(2), just as the arpA/A-factor system in Streptomyces griseus...
  10. ncbi A developmentally regulated gene encoding a repressor-like protein is essential for sporulation in Streptomyces coelicolor A3(2)
    N J Ryding
    John Innes Centre, Norwich Research Park, UK
    Mol Microbiol 29:343-57. 1998
    ..PwhiH was directly dependent on the sigma factor encoded by another sporulation gene, whiG, as shown by in vivo and in vitro transcription analysis...
  11. ncbi Alteration of the synthesis of the Clp ATP-dependent protease affects morphological and physiological differentiation in Streptomyces
    V de Crecy-Lagard
    Unité de Biochimie Microbienne, URA 1300 CNRS, Institut Pasteur, 28 rue du Dr Roux, Paris cedex 75724, France
    Mol Microbiol 32:505-17. 1999
    ..Overexpression of clpP1 and clpP2 accelerates aerial mycelium formation in S. lividans, S. albus and S. coelicolor. Overproduction of ClpX accelerates actinorhodin production in S. coelicolor and activates its production in S. lividans...
  12. ncbi Structural rearrangements underlying K+-channel activation gating
    E Perozo
    Department of Molecular Physiology and Biological Physics and Center for Structural Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22906 0011, USA
    Science 285:73-8. 1999
    ..Although the extracellular residues flanking the selectivity filter remained immobile during gating, small movements were detected at the C-terminal end of the pore helix, with possible implications to the gating mechanism...
  13. ncbi A putative two-component signal transduction system regulates sigmaE, a sigma factor required for normal cell wall integrity in Streptomyces coelicolor A3(2)
    M S Paget
    John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Mol Microbiol 33:97-107. 1999
    ..We propose a model in which the CseB/CseC two-component system modulates activity of the sigE promoter in response to signals from the cell envelope...
  14. ncbi Multiple paralogous genes related to the Streptomyces coelicolor developmental regulatory gene whiB are present in Streptomyces and other actinomycetes
    J A Soliveri
    John Innes Centre Norwich Research Park, Colney, UK
    Microbiology 146:333-43. 2000
    ....
  15. pmc Roles of aconitase in growth, metabolism, and morphological differentiation of Streptomyces coelicolor
    P H Viollier
    Department of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Bacteriol 183:3193-203. 2001
    ..Immunoblots revealed that AcoA was present primarily during substrate mycelial growth on solid medium. Transcription of acoA was limited to the early growth phase in liquid cultures from a start site mapped in vitro and in vivo...
  16. ncbi Energetic optimization of ion conduction rate by the K+ selectivity filter
    J H Morais-Cabral
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nature 414:37-42. 2001
    ..The energetic balance between these configurations is a clear example of evolutionary optimization of protein function...
  17. ncbi Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution
    Y Zhou
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nature 414:43-8. 2001
    ..This structural change is crucial to the operation of the selectivity filter in the cellular context, where the K+ ion concentration near the selectivity filter varies in response to channel gating...
  18. pmc PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin
    Bertolt Gust
    Department of Molecular Microbiology, John Innes Centre, Colney, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 100:1541-6. 2003
    ....
  19. ncbi The promoter of a cold-shock-like gene has pleiotropic effects on Streptomyces antibiotic biosynthesis
    Oscar H Martinez-Costa
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    FEMS Microbiol Lett 220:215-21. 2003
    ..Interestingly, the csp1-groEL2 region pleiotropically regulates the production of antibiotics from Streptomyces coelicolor and Streptomyces nodosus...
  20. ncbi The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
    Yufeng Zhou
    Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute and Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Mol Biol 333:965-75. 2003
    ..We conclude that electrostatic balance and coupling of ion binding to a protein conformational change underlie high conduction rates in the setting of high selectivity...
  21. ncbi Crystal structure of a gamma-butyrolactone autoregulator receptor protein in Streptomyces coelicolor A3(2)
    Ryo Natsume
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, 113 8657, Tokyo, Japan
    J Mol Biol 336:409-19. 2004
    ....
  22. pmc The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor
    Shinya Kodani
    Department of Biology, Hofstra University, Hempstead, NY 11549, USA
    Proc Natl Acad Sci U S A 101:11448-53. 2004
    ..We conclude that SapB is derived from RamS through proteolytic cleavage and the introduction of four dehydroalanine residues and two lanthionine bridges. We provide an example of a morphogenetic role for an antibiotic-like molecule...
  23. ncbi The sugar phosphotransferase system of Streptomyces coelicolor is regulated by the GntR-family regulator DasR and links N-acetylglucosamine metabolism to the control of development
    Sebastien Rigali
    Department of Biochemistry, Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Mol Microbiol 61:1237-51. 2006
    ..Our work, and the model it suggests, provide new leads towards understanding how microorganisms time developmental commitment...
  24. ncbi Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation
    Francis I Valiyaveetil
    Laboratories of Molecular Neurobiology and Biophysics and Synthetic Protein Chemistry, Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021, USA
    Science 314:1004-7. 2006
    ....
  25. ncbi ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize gamma-butyrolactones
    Nai Hua Hsiao
    Mikrobiologie Biotechnologie, Eberhard Karls Universitat Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Microbiology 153:1394-404. 2007
    ....
  26. doi The Streptomyces coelicolor GlnR regulon: identification of new GlnR targets and evidence for a central role of GlnR in nitrogen metabolism in actinomycetes
    Yvonne Tiffert
    Mikrobiologie Biotechnologie, Institut fur Mikrobiologie, Fakultat fur Biologie, Eberhard Karls Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Mol Microbiol 67:861-80. 2008
    ..coelicolor GlnR is able to interact with these glnA upstream regions. We therefore suggest that GlnR-mediated regulation is not restricted to Streptomyces but constitutes a regulon conserved in many actinomycetes...
  27. doi Characteristics of the surface-located carbohydrate-binding protein CbpC from Streptomyces coelicolor A32
    Stefan Walter
    FB Biologie Chemie, Universitat Osnabruck, Barbarastr 11, 49069 Osnabruck, Germany
    Arch Microbiol 190:119-27. 2008
    ..As demonstrated by analysing further truncated CbpC-forms a glycine-aspartate/serine rich region, which separates the carbohydrate-binding module from the sorting signal, plays an important role in protein stability...
  28. pmc FtsW is a dispensable cell division protein required for Z-ring stabilization during sporulation septation in Streptomyces coelicolor
    Bhavesh V Mistry
    Institute of Life Science, School of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, United Kingdom
    J Bacteriol 190:5555-66. 2008
    ....
  29. pmc Assemblies of DivIVA mark sites for hyphal branching and can establish new zones of cell wall growth in Streptomyces coelicolor
    Antje Marie Hempel
    Department of Cell and Organism Biology, Lund University, Sölvegatan 35, 223 62 Lund, Sweden
    J Bacteriol 190:7579-83. 2008
    ..Overexpression experiments showed that DivIVA foci can trigger establishment of new zones of cell wall assembly, suggesting a key role of DivIVA in directing peptidoglycan synthesis and cell shape in Streptomyces...
  30. pmc Genetic interactions of smc, ftsK, and parB genes in Streptomyces coelicolor and their developmental genome segregation phenotypes
    Rebekah M Dedrick
    Department of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA
    J Bacteriol 191:320-32. 2009
    ....
  31. pmc Imaging of Streptomyces coelicolor A3(2) with reduced autofluorescence reveals a novel stage of FtsZ localization
    Joost Willemse
    Department of Molecular Genetics, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
    PLoS ONE 4:e4242. 2009
    ..The enhanced imaging properties are an important step forward for the confocal and live imaging of less abundant proteins and for the use of lower intensity fluorophores in streptomycetes...
  32. doi Characterization of the methyl-specific restriction system of Streptomyces coelicolor A3(2) and of the role played by laterally acquired nucleases
    Gabriela González-Cerón
    Departamento de Biologia Molecular y Biotecnologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, DF, Mexico
    FEMS Microbiol Lett 301:35-43. 2009
    ..Cloning of these genes in the close relative Streptomyces lividans increased the restriction of methylated DNA by this species, confirming their role as part of the methyl-specific restriction system of S. coelicolor...
  33. doi The complex whiJ locus mediates environmentally sensitive repression of development of Streptomyces coelicolor A3(2)
    José A Aínsa
    Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Antonie Van Leeuwenhoek 98:225-36. 2010
    ..It is suggested that this activity of SCO4542 protein is prevented by an unknown signal...
  34. doi FasR, a novel class of transcriptional regulator, governs the activation of fatty acid biosynthesis genes in Streptomyces coelicolor
    Ana Arabolaza
    Microbiology Division, Instituto de Biologia Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531 S2002LRK Rosario, Argentina
    Mol Microbiol 78:47-63. 2010
    ..These data provide the first example of positive regulation of genes encoding core proteins of saturated fatty acid synthase complex...
  35. ncbi Genes essential for morphological development and antibiotic production in Streptomyces coelicolor are targets of BldD during vegetative growth
    Chris D den Hengst
    Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Colney, Norwich NR47UH, UK
    Mol Microbiol 78:361-79. 2010
    ..High-scoring copies of the BldD binding site were found at relevant positions in the genomes of other bacteria containing a BldD homologue, suggesting the role of BldD is conserved in sporulating actinomycetes...
  36. doi The actinobacterial signature protein ParJ (SCO1662) regulates ParA polymerization and affects chromosome segregation and cell division during Streptomyces sporulation
    Bartosz Ditkowski
    Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Mol Microbiol 78:1403-15. 2010
    ..We hypothesize that polar growth, which is characteristic not only of streptomycetes, but even of simple Actinobacteria, may be interlinked with ParA polymer assembly and its specific regulation by ParJ...
  37. pmc Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA
    Guang Liu
    Laboratory of Microbial Metabolism and School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    PLoS Genet 6:e1001253. 2010
    ..This is the first report of in vitro endonuclease activity of a McrA homologue and also the first demonstration of an enzyme that specifically cleaves S-modified DNA...
  38. doi A novel role of 'pseudo'γ-butyrolactone receptors in controlling γ-butyrolactone biosynthesis in Streptomyces
    Juan Wang
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    Mol Microbiol 82:236-50. 2011
    ....
  39. doi High resolution crystal structure of Sco5413, a widespread actinomycete MarR family transcriptional regulator of unknown function
    Tracey A Holley
    Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom
    Proteins 81:176-82. 2013
    ....
  40. pmc Coiled-coil protein Scy is a key component of a multiprotein assembly controlling polarized growth in Streptomyces
    Neil A Holmes
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom
    Proc Natl Acad Sci U S A 110:E397-406. 2013
    ..We propose that Scy is a molecular "assembler," which, by sequestering DivIVA, promotes the establishment of new polarity centers for de novo tip formation during branching, as well as supporting polarized growth at existing hyphal tips...
  41. pmc Dynamics of FtsZ assembly during sporulation in Streptomyces coelicolor A3(2)
    Nina Grantcharova
    Dept of Cell and Organism Biology, Uppsala University, SE 751 24 Uppsala, Sweden
    J Bacteriol 187:3227-37. 2005
    ..They failed in up-regulation of the expression of FtsZ-EGFP in aerial hyphae, which is consistent with the known effects of these genes on ftsZ transcription...
  42. pmc Disruption of the siderophore-binding desE receptor gene in Streptomyces coelicolor A3(2) results in impaired growth in spite of multiple iron-siderophore transport systems
    Víctor H Tierrafría
    Evolution of Metabolic Diversity Laboratory, Laboratorio Nacional de Genómica para la Biodiversidad Langebio, CINVESTAV IPN, Km 9 6 Libramiento Norte, Carretera Irapuato León, Irapuato, C P 36822, Mexico
    Microb Biotechnol 4:275-85. 2011
    ..The biotechnological and ecological implications of these observations are discussed...
  43. doi PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis in Streptomyces cacaoi
    Rui Li
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    Mol Microbiol 75:349-64. 2010
    ..These results suggested that the ATPase domain might be a sensor of endogenous pool of ADP/ATP, whose change modulated PolY activity under the physiological conditions...
  44. pmc Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol
    Mamoru Komatsu
    Kitasato Institute for Life Sciences, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Proc Natl Acad Sci U S A 105:7422-7. 2008
    ..We concluded that the biosynthetic pathway involves the methylation of GPP by GPP methyltransferase and its subsequent cyclization by monoterpene cyclase to 2-MIB...
  45. doi Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus
    Setsu Hirano
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Microbiology 154:905-14. 2008
    ..Therefore, AtrA-g had a conditionally positive effect on streptomycin production, as a tuner, probably by enhancing the AdpA-dependent transcriptional activation of strR in a still unknown manner...
  46. ncbi Identification of a novel two-component system SenS/SenR modulating the production of the catalase-peroxidase CpeB and the haem-binding protein HbpS in Streptomyces reticuli
    Darío Ortiz de Orué Lucana
    FB Biologie Chemie, Universitat Osnabruck, Barbarastr 11, D 49069 Osnabruck, Germany
    Microbiology 151:3603-14. 2005
    ..Hence the SenS/SenR system appears to be confined to streptomycetes...
  47. pmc Dual transcriptional control of amfTSBA, which regulates the onset of cellular differentiation in Streptomyces griseus
    Kenji Ueda
    Life Science Research Center, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252 8510, Japan
    J Bacteriol 187:135-42. 2005
    ..griseus...
  48. pmc Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350
    Yasuo Ohnishi
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Bacteriol 190:4050-60. 2008
    ..griseus...
  49. pmc bldA-dependent expression of the Streptomyces exfoliatus M11 lipase gene (lipA) is mediated by the product of a contiguous gene, lipR, encoding a putative transcriptional activator
    L Servin-Gonzalez
    Departamento de Biologia Molecular, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, D F, Mexico
    J Bacteriol 179:7816-26. 1997
    ....
  50. ncbi Chitinase inhibitor allosamidin promotes chitinase production of Streptomyces generally
    Shigeo Suzuki
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Int J Biol Macromol 43:13-9. 2008
    ..These observations suggested that allosamidin can affect the common regulatory system for production of a chitinase with a two-component regulatory system in Streptomyces...
  51. ncbi Distribution and evolution of chitinase genes in Streptomyces species: involvement of gene-duplication and domain-deletion
    A Saito
    National Institute of Agro Environmental Sciences, Kan nondai 3 1 1, Tsukuba, Ibaraki 305 8604, Japan
    Antonie Van Leeuwenhoek 84:7-15. 2003
    ..It was thus shown that gene-duplication and domain-deletion were implicated in generating the high diversity and multiplicity of chitinase genes in Streptomyces species...
  52. ncbi Cloning of midecamycin(MLS)-resistance genes from Streptomyces mycarofaciens, Streptomyces lividans and Streptomyces coelicolor A3(2)
    O Hara
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Yokohama, Japan
    J Antibiot (Tokyo) 43:977-91. 1990
    ....
  53. pmc Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains
    Yong Soon Hwang
    School of Chemical Engineering, Seoul National University, Seoul, Korea
    Appl Environ Microbiol 69:1263-9. 2003
    ..Although the nature of the stimulatory effect is still unclear, the disruption of orfX revealed that this gene was intrinsically involved in the stimulation of avermectin production in S. avermitilis...
  54. pmc Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces
    Juan F Martin
    INBIOTEC, Instituto de Biotecnologia de Leon, Avda Real n 1, Parque Cientifico de Leon, 24006 Leon, Spain
    Microb Biotechnol 4:165-74. 2011
    ..These findings provide the bases for understanding the mechanisms underlying systems biology of Streptomyces species...
  55. ncbi Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2)
    David C Lamb
    Institute of Biological Sciences, University of Wales Aberystwyth, Aberystwyth, UK
    Biochem Biophys Res Commun 307:610-9. 2003
    ..Amongst this range of CYPs are forms associated with avermectin, filipin, geosmin, and pentalenolactone biosynthesis as well as unknown pathways of secondary metabolism...
  56. ncbi David Hopwood and the emergence of Streptomyces genetics
    K Chater
    John Innes Centre, Norwich, UK
    Int Microbiol 2:61-8. 1999
    ..Most recently, his involvement in the physical mapping of the entire 8 Mb genome of S. coelicolor A3(2) has culminated in its complete DNA sequencing: a project that should be completed under his management during the year 2000...
  57. pmc Occurrence of two 5-aminolevulinate biosynthetic pathways in Streptomyces nodosus subsp. asukaensis is linked with the production of asukamycin
    Miroslav Petricek
    Institute of Microbiology AS CR, Videnska 1083, 142 20 Prague 4, Czech Republic
    J Bacteriol 188:5113-23. 2006
    ..The hemA-asuA gene is situated within a putative cluster of asukamycin biosynthetic genes. This is the first report about the cloning of genes for two different ALA biosynthetic routes from a single bacterium...
  58. pmc Characterization of a silent sesquiterpenoid biosynthetic pathway in Streptomyces avermitilis controlling epi-isozizaene albaflavenone biosynthesis and isolation of a new oxidized epi-isozizaene metabolite
    Satoshi Takamatsu
    Kitasato Institute for Life Sciences, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Microb Biotechnol 4:184-91. 2011
    ..avermitilis SUKA16 transformants in which sav3032 was coexpressed with the P450-encoding sav3031. This new metabolite was identified as 4β,5β-epoxy-2-epi-zizaan-6β-ol which is most likely formed by oxidation of (4S)-albaflavenol...
  59. pmc The anti-anti-sigma factor BldG is involved in activation of the stress response sigma factor σ(H) in Streptomyces coelicolor A3(2)
    Beatrica Sevcikova
    Institute of Molecular Biology, Slovak Academy of Sciences, Dubravska cesta 21, 845 51 Bratislava, Slovak Republic
    J Bacteriol 192:5674-81. 2010
    ..coelicolor bldG mutant, indicating a role of BldG in σ(H) activation by a partner-switching-like mechanism...
  60. pmc Evidence that the extracytoplasmic function sigma factor sigmaE is required for normal cell wall structure in Streptomyces coelicolor A3(2)
    M S Paget
    John Innes Centre, Colney, Norwich NR4 7UH, United Kingdom
    J Bacteriol 181:204-11. 1999
    ..Growth on media deficient in magnesium caused the induction of both hrdD promoters in a sigE-dependent manner...
  61. doi Adenosine deaminase from Streptomyces coelicolor: recombinant expression, purification and characterization
    Somchai Pornbanlualap
    Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand
    Protein Expr Purif 78:167-73. 2011
    ....
  62. ncbi Synthesis of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) with thermostabilized low-specific L-threonine aldolase from Streptomyces coelicolor A3(2)
    Sang Ho Balk
    NITE Biological Resource Center, National Institute of Technology and Evaluation, 2 5 8 Kazusa kamatari, Kisarazu shi, Chiba 292 0818, Japan
    J Microbiol Biotechnol 17:721-7. 2007
    ..0 mg/ml of L-threo-DOPS. This result showed that H44 L-TA is more effective than the wild-type L-TA for the mass production of L-threo-DOPS...
  63. ncbi The stress-response sigma factor sigma(H) controls the expression of ssgB, a homologue of the sporulation-specific cell division gene ssgA, in Streptomyces coelicolor A3(2)
    J Kormanec
    Institute of Molecular Biology, Slovak Academy of Sciences, Dubravska cesta 21, 842 51 Bratislava, Slovak Republic
    Mol Genet Genomics 267:536-43. 2002
    ..Expression of ssgB was deregulated in three of the mutants ( whiA, whiI, and whiJ). Based on these data, it is proposed that the ssgB gene product plays a role in the developmental process in S. coelicolor A3(2)...
  64. pmc Relationships between fatty acid and polyketide synthases from Streptomyces coelicolor A3(2): characterization of the fatty acid synthase acyl carrier protein
    W P Revill
    John Innes Centre, Norwich Research Park, Colney, United Kingdom
    J Bacteriol 178:5660-7. 1996
    ..This suggests that the FAS and PKS ACPs may be biochemically incompatible and that this could prevent functional complementation between the FAS and PKSs that potentially coexist within the same cells...
  65. ncbi A relA/spoT homologous gene from Streptomyces coelicolor A3(2) controls antibiotic biosynthetic genes
    O H Martínez-Costa
    Centro Nacional de Biotecnologia, Campus Universidad Autonoma de Madrid, Spain
    J Biol Chem 271:10627-34. 1996
    ..p)ppGpp synthetase activity was not detected in purified ribosomes from the ORF1-deleted mutant, while it was restored by complementation of this strain...
  66. ncbi Transposition of IS117 of Streptomyces coelicolor A3(2) in Mycobacterium smegmatis
    A Bhatt
    Department of Genetics, John Innes Centre, Norwich Research Park, Colney, UK
    Microbiology 145:1201-7. 1999
    ..smegmatis in the absence of selection for at least 60 cell divisions. pIJ4696, pIJ4697 and other IS117 derivatives are promising vectors for the stable, integrative cloning of genes in M. smegmatis...
  67. ncbi Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2)
    Young Jin Chun
    Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 282:17486-500. 2007
    ..Thus, an electron transfer pathway to a functional Streptomyces P450 has been established...
  68. ncbi Tricorn protease in bacteria: characterization of the enzyme from Streptomyces coelicolor
    N Tamura
    Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Biol Chem 382:449-58. 2001
    ....
  69. pmc sigma(BldN), an extracytoplasmic function RNA polymerase sigma factor required for aerial mycelium formation in Streptomyces coelicolor A3(2)
    M J Bibb
    Department of Molecular Microbiology, John Innes Centre, Colney, Norwich NR4 7UH, United Kingdom
    J Bacteriol 182:4606-16. 2000
    ..Transcription from the p1 promoter of the response-regulator gene bldM depended on bldN in vivo, and the bldMp1 promoter was shown to be a direct biochemical target for sigma(BldN) holoenzyme in vitro...
  70. doi Degradation of chitosans with chitinase G from Streptomyces coelicolor A3(2): production of chito-oligosaccharides and insight into subsite specificities
    Ellinor B Heggset
    Norwegian Biopolymer Laboratory, Department of Biotechnology, Norwegian University of Science and Technology, 7491 Trondheim, Norway
    Biomacromolecules 10:892-9. 2009
    ..These results provide insight into the properties of bacterial family 19 chitinases and show how these enzymes may be used to convert chitosans to several types of chito-oligosaccharide mixtures...
  71. ncbi Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)
    M P Crump
    School of Chemistry, University of Bristol Molecular Recognition Centre, University of Bristol, U K
    Biochemistry 36:6000-8. 1997
    ..The structure-function relationship of act ACP is discussed in the light of these structural data and recent genetic advances in the field...
  72. pmc sigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2)
    M S Paget
    John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    EMBO J 17:5776-82. 1998
    ..We present evidence that the sigmaR system also functions in the actinomycete pathogen Mycobacterium tuberculosis...
  73. ncbi Evidence that a single EF-Ts suffices for the recycling of multiple and divergent EF-Tu species in Streptomyces coelicolor A3(2) and Streptomyces ramocissimus
    G Hoogvliet
    Department of Biochemistry, Leiden Institute of Chemistry, Leiden University, The Netherlands
    Microbiology 145:2293-301. 1999
    ..These apparently enable productive interaction to occur with all three EF-Tus...
  74. ncbi Quantitative relationships for specific growth rates and macromolecular compositions of Mycobacterium tuberculosis, Streptomyces coelicolor A3(2) and Escherichia coli B/r: an integrative theoretical approach
    Robert A Cox
    Division of Mycobacterial Research, National Institute for Medical Research, London NW7 1AA, UK
    Microbiology 150:1413-26. 2004
    ..tuberculosis with one rrn operon should be capable of growing much faster than it actually does. Therefore, it is suggested that the high number of insertion sequences in this species attenuates growth rate to still lower values...
  75. pmc The zinc-responsive regulator Zur controls a zinc uptake system and some ribosomal proteins in Streptomyces coelicolor A3(2)
    Jung Ho Shin
    School of Biological Sciences, Seoul National University, Kwanak gu, Seoul 151 742, Korea
    J Bacteriol 189:4070-7. 2007
    ..This sequence closely matches that for mycobacterial Zur and allows the prediction of more genes in the Zur regulon...
  76. doi High expression levels of chitinase genes in Streptomyces coelicolor A3(2) grown in soil
    Behnam Nazari
    Institute of Applied Biochemistry, Graduate School of Life and Environmental Sciences, The University of Tsukuba, Tsukuba, Ibaraki, Japan
    FEMS Microbiol Ecol 77:623-35. 2011
    ..The disruption of dasR, a transcriptional regulator for the uptake of N-acetylglucosamine, abolished the expression of chiH, demonstrating that DasR is required for the regulation of ChiH expression...
  77. ncbi The linear plasmid SCP1 of Streptomyces coelicolor A3(2) possesses a centrally located replication origin and shows significant homology to the transposon Tn4811
    M Redenbach
    Genome Research Unit, Kaiserslautern University, Kaiserslautern, 67663, Germany
    Plasmid 42:174-85. 1999
    ..In addition, we have identified a region in both terminal inverted repeats of SCP1 that shows significant homology to the transposable element Tn4811 located near the ends of the S. lividans 66 chromosome...
  78. ncbi A complex role for the gamma-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2)
    E Takano
    Department of Molecular Microbiology, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Mol Microbiol 41:1015-28. 2001
    ..Overall, these results indicate a complex mechanism for gamma-butyrolactone-mediated regulation of antibiotic biosynthesis in S. coelicolor...
  79. doi Distinct extracytoplasmic siderophore binding proteins recognize ferrioxamines and ferricoelichelin in Streptomyces coelicolor A3(2)
    Prakash Patel
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Biochemistry 49:8033-42. 2010
    ..The remarkable specificity of the DesE and CchF proteins for different ferric-tris-hydroxamates raises intriguing questions about the molecular basis of their substrate specificity...
  80. pmc Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinant
    W P Revill
    John Innes Centre, Norwich Research Park, Colney, United Kingdom
    J Bacteriol 177:3946-52. 1995
    ..coelicolor. Disruption of the operon containing the malonyltransferase gene proved to be impossible, supporting the idea that the malonyltransferase plays an essential role in fatty acid biosynthesis...
  81. pmc Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2)
    Y Li
    Department of Microbiology, Ohio State University, Columbus 43210 1292, USA
    J Bacteriol 178:136-42. 1996
    ..Apparent homologs of ptpA were detected in other streptomycetes by Southern hybridization; the biological functions of PtpA and its putative homologs in streptomycetes are not yet known...
  82. ncbi The dnaK operon of Streptomyces coelicolor encodes a novel heat-shock protein which binds to the promoter region of the operon
    G Bucca
    Department of Biochemistry and Applied Molecular Biology, UMIST, Manchester, UK
    Mol Microbiol 17:663-74. 1995
    ..These results suggest that OrfX plays a direct role in the regulation of the dnaK operon...
  83. ncbi The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host
    K Ichinose
    Department of Genetics John Innes Centre Norwich Research Park Colney Norwich NR4 7UH UK
    Chem Biol 5:647-59. 1998
    ..Comparison of the complete gene clusters for the two metabolites is therefore of great interest...
  84. ncbi The expression of the trpD, trpC and trpBA genes of Streptomyces coelicolor A3(2) is regulated by growth rate and growth phase but not by feedback repression
    D S Hu
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Mol Microbiol 32:869-80. 1999
    ..This growth phase-dependent and growth rate-dependent regulation is the first reported in streptomycete primary metabolism...
  85. pmc Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses
    Jan Bursy
    Laboratory for Microbiology, Department of Biology, Philipps University Marburg, Marburg, Germany
    Appl Environ Microbiol 74:7286-96. 2008
    ..coelicolor A3(2), Streptomyces avermitilis, Streptomyces griseus, Streptomyces scabiei, and Streptomyces chrysomallus, suggesting that these compatible solutes play an important role as stress protectants in the genus Streptomyces...
  86. pmc Export of functional Streptomyces coelicolor alditol oxidase to the periplasm or cell surface of Escherichia coli and its application in whole-cell biocatalysis
    Edwin van Bloois
    Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands
    Appl Microbiol Biotechnol 83:679-87. 2009
    ..It is anticipated that these whole-cell systems will be a valuable tool for further biological and industrial exploitation of AldO and other cofactor-containing enzymes...
  87. ncbi Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2)
    E Rodriguez
    Departamento de Microbiologia, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Argentina
    Microbiology 145:3109-19. 1999
    ..The fact that accA2 mutants appear to be inviable suggests that this gene encodes a biotinylated protein that might be shared with other carboxyl transferases essential for the growth of S. coelicolor...
  88. ncbi Sequences and evolutionary analyses of eukaryotic-type protein kinases from Streptomyces coelicolor A3(2)
    H Ogawara
    Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Microbiology 145:3343-52. 1999
    ..This conclusion is supported by the observation that the prokaryotes retaining several of these kinases undergo complicated morphological and/or biochemical differentiation...
  89. ncbi Defining the disulphide stress response in Streptomyces coelicolor A3(2): identification of the sigmaR regulon
    M S Paget
    Department of Molecular Microbiology, John Innes Centre, Colney, Norwich NR4 7UH, UK
    Mol Microbiol 42:1007-20. 2001
    ..We present DNA sequence evidence that many of the targets identified in S. coelicolor are also under the control of the sigmaR homologue in the actinomycete pathogen Mycobacterium tuberculosis...
  90. ncbi AfsR as an integrator of signals that are sensed by multiple serine/threonine kinases in Streptomyces coelicolor A3(2)
    Sueharu Horinouchi
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, 113 8657 Tokyo, Japan
    J Ind Microbiol Biotechnol 30:462-7. 2003
    ..AfsS induced in this way activates transcription of pathway-specific transcriptional activators, such as actII-ORF4 for actinorhodin production and redD for undecylprodigiosin, in an as yet unknown manner...
  91. ncbi Essential amino acid residues in the central transmembrane domains and loops for energy coupling of Streptomyces coelicolor A3(2) H+-pyrophosphatase
    Megumi Hirono
    Laboratory of Cell Dynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochim Biophys Acta 1767:930-9. 2007
    ..H+-pyrophosphatase activity might involve dynamic linkage between the hydrophilic and transmembrane domains...
  92. pmc Manipulating and understanding antibiotic production in Streptomyces coelicolor A3(2) with decoy oligonucleotides
    Michael McArthur
    Department of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 105:1020-5. 2008
    ....
  93. doi The obligate aerobe Streptomyces coelicolor A3(2) synthesizes three active respiratory nitrate reductases
    Marco Fischer
    Institute of Biology Microbiology, Martin Luther University Halle Wittenberg, 06120 Halle Saale, Germany
    Microbiology 156:3166-79. 2010
    ..The data obtained from these studies allow a tentative assignment of Nar1 activity to spores, Nar2 to spores and mycelium, and Nar3 exclusively to mycelium...
  94. pmc Two developmentally controlled promoters of Streptomyces coelicolor A3(2) that resemble the major class of motility-related promoters in other bacteria
    H Tan
    John Innes Institute, John Innes Centre, Norwich, United Kingdom
    J Bacteriol 175:933-40. 1993
    ..Thus, in unknown circumstances, the whiG-dependent ORFs may be expressed from a more remote promoter as part of a complex transcription unit...
  95. ncbi The positions of the sigma-factor genes, whiG and sigF, in the hierarchy controlling the development of spore chains in the aerial hyphae of Streptomyces coelicolor A3(2)
    G H Kelemen
    Department of Genetics, John Innes Centre, Colney, Norwich, UK
    Mol Microbiol 21:593-603. 1996
    ..These results show that there is a hierarchical relationship between sigma factors required for Streptomyces sporulation and also that at least five other genes are involved in this transcriptional network...
  96. ncbi A 'gram-negative-type' DNA polymerase III is essential for replication of the linear chromosome of Streptomyces coelicolor A3(2)
    F Flett
    Department of Biomolecular Sciences, UMIST, Manchester, UK
    Mol Microbiol 31:949-58. 1999
    ....
  97. pmc Functional analysis of relA and rshA, two relA/spoT homologues of Streptomyces coelicolor A3(2)
    J Sun
    Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, United Kingdom
    J Bacteriol 183:3488-98. 2001
    ..Thus, a ppGpp-independent mechanism exists to activate antibiotic production under conditions of phosphate limitation that can be mimicked by overexpression of rshA...
  98. ncbi A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor
    Eriko Takano
    Mikrobiologie Biotechnologie, Eberhard Karls Universitat Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Mol Microbiol 56:465-79. 2005
    ..This is the first report with comprehensive in vivo and in vitro data to show that a gamma-butyrolactone-binding protein directly regulates a secondary metabolite pathway-specific regulatory gene in Streptomyces...
  99. ncbi The SCO2299 gene from Streptomyces coelicolor A3(2) encodes a bifunctional enzyme consisting of an RNase H domain and an acid phosphatase domain
    Naoto Ohtani
    Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan
    FEBS J 272:2828-37. 2005
    ..However, the bifunctional enzyme examined here is a novel style in the Type 1 RNase H family. Additionally, S. coelicolor is the first example of an organism whose genome contains three active RNase H genes...
  100. ncbi Quantitative fluorometric analysis of the protective effect of chitosan on thermal unfolding of catalytically active native and genetically-engineered chitosanases
    Sébastien Roy
    Diversified Natural Products Research Laboratory, Institut de Pharmacologie, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Biochim Biophys Acta 1774:975-84. 2007
    ....
  101. ncbi The glucose kinase gene of Streptomyces coelicolor A3(2): its nucleotide sequence, transcriptional analysis and role in glucose repression
    S Angell
    John Innes Institute, John Innes Centre, Norwich, UK
    Mol Microbiol 6:2833-44. 1992
    ..coli glk mutant, and activity gels of cell extracts of E. coli containing ORF3 cloned in the pT7-7 expression vector demonstrated that the ORF3 product has glucose kinase activity...

Research Grants4

  1. Type III Polyketide Synthases: Structure and Mechanism
    BRADLEY MOORE; Fiscal Year: 2006
    ..abstract_text> ..
  2. BIOSYNTHESIS AND METABOLISM OF CYCLOPENTANOIDS
    Ronald Parry; Fiscal Year: 2001
    ..The potential use of the CmaA gene for construction of hybrid peptide antibiotics containing L-alloisoleucine or coronamic acid will also be explored, using surfactin biosynthesis in B. subtilis as a model system. ..
  3. BIOSYNTHESIS OF SOME MICROBIAL METABOLITES
    Ronald Parry; Fiscal Year: 2007
    ..Future investigations of sparsomycin will focus on cloning the sparsomycin resistance gene from S. sparsogenes to understand the mechanism of self-resistance in this organism and to gain access to the biosynthetic genes. ..

Patents28

  1. CYANOBACTERIA HAVING IMPROVED PHOTOSYNTHETIC ACTIVITY
    Patent Number: WO2016044336-A1; Date:2016-03-24
  2. Agar-derived neoagarooligosaccharide complex for the prevention and treatment of obesity and/or diabetes comprising enzyme reaction products of beta agarase DagA and agar
    Patent Number: JP2016505521-A; Date:2016-02-25
  3. MODIFIED DIACYLGLYCEROL ACYLTRANSFERASE PROTEINS AND METHODS OF USE THEREOF
    Patent Number: JP2015509533-A; Date:2015-03-30
  4. A method for improving the material productivity of microorganisms and a kit for use in the method
    Patent Number: WO2015182719-A; Date:2015-12-03
  5. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  6. Process for the production of a fine chemical
    Patent Number: WO2008034648-A1; Date:2008-03-27
  7. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  8. RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES
    Patent Number: KR1020130117753-A; Date:2013-10-28
  9. CONSTRUCTS FOR EXPRESSING HERBICIDE TOLERANCE GENES, RELATED PLANTS, AND RELATED TRAIT COMBINATIONS
    Patent Number: EP2299804-A2; Date:2011-03-30
  10. Site-specific genetic recombination method based on TG1 integrase
    Patent Number: JP2011142867-A; Date:2011-07-28
  11. Expression system of actinomycete-origin cytochrome P-450 in escherichia coli
    Patent Number: WO2003087381-A; Date:2003-10-23
  12. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  13. Plants with increased yield (nue)
    Patent Number: WO2010046221-A1; Date:2010-04-29
  14. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  15. Plants with increased yield (lt)
    Patent Number: WO2010034672-A1; Date:2010-04-01
  16. Plants with increased yield by increasing or generating one or more activities in a plant or a part thereof
    Patent Number: WO2010020654-A2; Date:2010-02-25
  17. Plants with increased yield
    Patent Number: WO2009106596-A2; Date:2009-09-03
  18. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  19. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
  20. Lipid metabolism proteins, combinations of lipid metabolism proteins and uses thereof
    Patent Number: WO2009077406-A1; Date:2009-06-25
  21. Plants with increased yield and/or increased tolerance to environmental stress (iy-bm)
    Patent Number: WO2009077611-A2; Date:2009-06-25
  22. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  23. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  24. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  25. MODIFIED PHOTOSYNTHETIC MICROORGANISMS FOR PRODUCING LIPIDS
    Patent Number: WO2012087982-A2; Date:2012-06-28
  26. Transglycosylation method and method for producing glycoprotein
    Patent Number: EP1767645-A1; Date:2007-03-28
  27. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  28. Type II thioesterase from Streptomyces coelicolor a3(2) and the coding sequence
    Patent Number: WO02079461-A2; Date:2002-10-10