Mycobacterium bovis AF2122/97

Summary

Alias: Mycobacterium bovis str. AF2122/97, Mycobacterium bovis subsp. bovis AF2122/97, Mycobacterium bovis subsp. bovis str. AF2122/97

Top Publications

  1. ncbi Cloning and sequence analysis of the gene encoding an NADP-dependent alcohol dehydrogenase in Mycobacterium bovis BCG
    M Stelandre
    Institut Pasteur du Brabant, Bruxelles, Belgium
    Gene 121:79-86. 1992
  2. ncbi Complete nucleotide sequence of immunogenic protein MPB70 from Mycobacterium bovis BCG
    K Terasaka
    Research Institute for Microbial Diseases, Osaka University, Japan
    FEMS Microbiol Lett 49:273-6. 1989
  3. pmc Cloning of a species-specific antigen of Mycobacterium bovis
    A J Radford
    Division of Animal Health, Commonwealth Scientific and Industrial Research Organisation, Parkville, Victoria, Australia
    Infect Immun 56:921-5. 1988
  4. ncbi Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis
    A Dessen
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461
    Science 267:1638-41. 1995
  5. ncbi Cloning and sequencing of an MPB70 homologue corresponding to MPB83 from Mycobacterium bovis BCG
    T Matsuo
    School of Dentistry, Nagasaki University, Japan
    Scand J Immunol 43:483-9. 1996
  6. ncbi Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus
    A Scorpio
    Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Nat Med 2:662-7. 1996
  7. ncbi Complete sequence of the UPP gene encoding uracil phosphoribosyltransferase from Mycobacterium bovis BCG
    J K Kim
    Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, Korea
    Biochem Mol Biol Int 41:1117-24. 1997
  8. ncbi Cloning and sequencing of the secY gene homolog from Mycobacterium bovis BCG
    J K Kim
    Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
    Biochem Mol Biol Int 43:391-8. 1997
  9. ncbi Cloning and sequencing of the pyrG encoding cytidine 5'-triphosphate synthetase from Mycobacterium bovis BCG
    J H Kim
    Korea Research Institute of Bioscience and Biotechnology, Taejon
    Biochem Mol Biol Int 43:925-33. 1997
  10. pmc Identification and characterization of a 29-kilodalton protein from Mycobacterium tuberculosis culture filtrate recognized by mouse memory effector cells
    I Rosenkrands
    Department of TB Immunology, Statens Serum Institut, Copenhagen, Denmark
    Infect Immun 66:2728-35. 1998

Patents

  1. ENZYMATIC SYSTEM-CONTAINING COSMETIC COMPOSITIONS
  2. ENZYMATIC SYSTEM-CONTAINING COSMETIC COMPOSITIONS
  3. Plants with increased yield
  4. Plants with increased yield and/or increased tolerance to environmental stress (iy-bm)
  5. Lipid metabolism proteins, combinations of lipid metabolism proteins and uses thereof
  6. Process for the production of a fine chemical
  7. Process for the production of lutein
  8. Process for the production of fine chemicals
  9. Process for the control of production of fine chemicals
  10. GENETIC VACCINE AGAINST INTRACELLULAR PARASITIC PATHOGENS

Scientific Experts

  • Rajan Sankaranarayanan
  • Mark Andrew Chambers
  • Thomas Zahrt
  • Daniel H Anderson
  • MIRIAM S BRAUNSTEIN
  • L M Podust
  • M L Beggs
  • Andrea Jesenská
  • Veerabadran Dheenadhayalan
  • S T Cole
  • Mamta Rawat
  • F Bigi
  • Na Liu
  • J K Kim
  • Toidi Adekambi
  • Barnali N Chaudhuri
  • James C Sacchettini
  • Liu He
  • Jin Sik Kim
  • Bhagwati Khatri
  • Xiaolang Cai
  • Nadia Raffaelli
  • Nesty Olivares Arzuaga
  • T Rotman
  • Y K Choe
  • N Ohara
  • Paul R Wheeler
  • Clare V Smith
  • W R Jacobs
  • Chih Chin Huang
  • Christine L Cosma
  • Narayani P Kar
  • J H Kim
  • J C Sacchettini
  • Georgia Kefala
  • T W Chung
  • Sung Koo Kang
  • Stephanie Petrella
  • Jesús Gonzalo Asensio
  • Martha V Radchenko
  • I S Choe
  • Battouli Said-Salim
  • T Yamada
  • Stephane T Temmerman
  • Hongjun He
  • Peter Sperisen
  • Lisa A Keating
  • Yue Li
  • E Dubnau
  • Michel Drancourt
  • Rosalind A Wilson
  • Limei Meng Okkels
  • L Jeanne Perry
  • Silvia Garavaglia
  • Giulio Magni
  • Raju Rukmini
  • J Preben Morth
  • John Buglino
  • Anne Walburger
  • Lucia Finaurini
  • T Matsuo
  • Todd O Yeates
  • F D Menozzi
  • Yoonsang Cho
  • Jason T Maynes
  • Mack R Kuo
  • Andrzej Lewandowicz
  • S H Cho
  • H G Lee
  • S J Kim
  • Xiangmei Zhou
  • Kai Fan
  • J S Lim
  • Deming Zhao
  • Lifeng Yang
  • Lihong Tian
  • William R Jacobs
  • Xiaomin Yin
  • D M Collins
  • Jeong Il Oh
  • Kwang Pil Choi
  • Nam Chul Ha
  • M Ucko
  • Calvin Boon
  • Li Jiao
  • Yong Hak Kim
  • Gareth Jones
  • Manal Abu-Oun
  • William Newell
  • Mark Fielder

Detail Information

Publications122 found, 100 shown here

  1. ncbi Cloning and sequence analysis of the gene encoding an NADP-dependent alcohol dehydrogenase in Mycobacterium bovis BCG
    M Stelandre
    Institut Pasteur du Brabant, Bruxelles, Belgium
    Gene 121:79-86. 1992
    ..Of the 22 strictly conserved residues in this group, 19 are also conserved in M. bovis BCG ADH (BCGADH)...
  2. ncbi Complete nucleotide sequence of immunogenic protein MPB70 from Mycobacterium bovis BCG
    K Terasaka
    Research Institute for Microbial Diseases, Osaka University, Japan
    FEMS Microbiol Lett 49:273-6. 1989
    ..The SP displayed a characteristic feature of an Ala-rich property which would be efficient in a SP function...
  3. pmc Cloning of a species-specific antigen of Mycobacterium bovis
    A J Radford
    Division of Animal Health, Commonwealth Scientific and Industrial Research Organisation, Parkville, Victoria, Australia
    Infect Immun 56:921-5. 1988
    ..Apart from this deletion, there were seven other variations between the cloned sequence and that deduced from M. bovis BCG MPB70...
  4. ncbi Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis
    A Dessen
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461
    Science 267:1638-41. 1995
    ..2 and 2.7 angstroms, respectively, revealed that drug resistance is directly related to a perturbation in the hydrogen-bonding network that stabilizes NADH binding...
  5. ncbi Cloning and sequencing of an MPB70 homologue corresponding to MPB83 from Mycobacterium bovis BCG
    T Matsuo
    School of Dentistry, Nagasaki University, Japan
    Scand J Immunol 43:483-9. 1996
    ..It was speculated that the gene the authors characterized probably corresponded to the mpb83 gene...
  6. ncbi Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus
    A Scorpio
    Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Nat Med 2:662-7. 1996
    ..tuberculosis and also for rapid differentiation of M. bovis from M. tuberculosis strains...
  7. ncbi Complete sequence of the UPP gene encoding uracil phosphoribosyltransferase from Mycobacterium bovis BCG
    J K Kim
    Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, Korea
    Biochem Mol Biol Int 41:1117-24. 1997
    ..Comparative analyses of the deduced amino acid sequence of BCG UPRTase with the UPRTase of six bacterial genera revealed that 24% (50/211) of the residues are perfectly conserved and 32% (67/211) of the residues are well conserved...
  8. ncbi Cloning and sequencing of the secY gene homolog from Mycobacterium bovis BCG
    J K Kim
    Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
    Biochem Mol Biol Int 43:391-8. 1997
    ..Comparative analyses of the deduced amino acid sequence of additional partial ORF revealed strong similarity to the known adenylate kinases...
  9. ncbi Cloning and sequencing of the pyrG encoding cytidine 5'-triphosphate synthetase from Mycobacterium bovis BCG
    J H Kim
    Korea Research Institute of Bioscience and Biotechnology, Taejon
    Biochem Mol Biol Int 43:925-33. 1997
    ....
  10. pmc Identification and characterization of a 29-kilodalton protein from Mycobacterium tuberculosis culture filtrate recognized by mouse memory effector cells
    I Rosenkrands
    Department of TB Immunology, Statens Serum Institut, Copenhagen, Denmark
    Infect Immun 66:2728-35. 1998
    ..Interspecies analysis by immunoblotting and PCR demonstrated that CFP29 is widely distributed in mycobacterial species...
  11. ncbi Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines
    D R Ronning
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77844 2128, USA
    Nat Struct Biol 7:141-6. 2000
    ..Also, a large region of conserved surface residues among ag85A, B and C is a probable site for the interaction of ag85 proteins with human fibronectin...
  12. ncbi Genomic arrangement of a putative operon involved in maltose transport in the Mycobacterium tuberculosis complex and Mycobacterium leprae
    S M Borich
    Mycobacteriology Research Laboratory, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand
    Microbios 102:7-15. 2000
    ..leprae...
  13. pmc Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors
    L M Podust
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Proc Natl Acad Sci U S A 98:3068-73. 2001
    ..These new structures provide a basis for rational design of new, more efficacious antifungal agents as well as insight into the molecular mechanism of P450 catalysis...
  14. ncbi Identification of a cadmium-induced gene in Mycobacterium bovis and Mycobacterium tuberculosis
    G S Hotter
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    FEMS Microbiol Lett 200:151-5. 2001
    ..Only the long fragment directed cadmium-inducible activity when electroporated into M. bovis. The cadI promoter has potential for both constitutive and inducible expression studies in M. bovis and M. tuberculosis...
  15. pmc Use of transposon Tn5367 mutagenesis and a nitroimidazopyran-based selection system to demonstrate a requirement for fbiA and fbiB in coenzyme F(420) biosynthesis by Mycobacterium bovis BCG
    K P Choi
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 183:7058-66. 2001
    ..The specific reactions catalyzed by FbiA and FbiB are unknown, but both function between FO and F(420)-5,6, since FO is made by both mutants...
  16. ncbi Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis
    Clare V Smith
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    J Biol Chem 278:1735-43. 2003
    ..7-A resolution. Coenzyme A binds in a bent conformation, and the details of its interactions are described, together with implications on the enzyme mechanism...
  17. pmc Strain variation in Mycobacterium marinum fish isolates
    M Ucko
    Israel Oceanographic and Limnological Research Ltd, National Center for Mariculture, Eilat, Israel
    Appl Environ Microbiol 68:5281-7. 2002
    ....
  18. pmc Mycobacterium bovis BCG response regulator essential for hypoxic dormancy
    Calvin Boon
    Mycobacterium Biology Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
    J Bacteriol 184:6760-7. 2002
    ..Our results provide conclusive evidence that DosR is a key regulator in the oxygen starvation-induced mycobacterial dormancy response...
  19. ncbi Crystallization and preliminary X-ray crystallographic investigations of an unusual type III polyketide synthase PKS18 from Mycobacterium tuberculosis
    Raju Rukmini
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
    Acta Crystallogr D Biol Crystallogr 60:749-51. 2004
    ..The crystal belongs to the triclinic space group P1, with unit-cell parameters a = 59.9, b = 80.7, c = 99.6 A, alpha = 108.2, beta = 93.0, gamma = 103.7 degrees...
  20. ncbi The pyruvate requirement of some members of the Mycobacterium tuberculosis complex is due to an inactive pyruvate kinase: implications for in vivo growth
    Lisa A Keating
    TB Research Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK
    Mol Microbiol 56:163-74. 2005
    ..In summary, the disruption of a key step in glycolysis divides the M. tuberculosis complex into two groups with distinct carbon source utilization...
  21. ncbi Catalase-peroxidase of Mycobacterium bovis BCG converts isoniazid to isonicotinamide, but not to isonicotinic acid: differentiation parameter between enzymes of Mycobacterium bovis BCG and Mycobacterium tuberculosis
    Sung Koo Kang
    Department of Biological Science, Sungkyunkwan University, 300 Chunchun dong, Jangan gu, Suwon City, Kyunggi 440 746, Korea
    Biochim Biophys Acta 1760:724-9. 2006
    ..bovis BCG, converts INH to isonicotinamide and this study may give us important new light on the activation mechanism of INH by KatG between M. bovis BCG and M. tuberculosis...
  22. ncbi Potassium/proton antiport system of Escherichia coli
    Martha V Radchenko
    Department of Microbiology, Niigata University of Pharmacy and Applied Life Sciences, Niigata 950 2081, Japan
    J Biol Chem 281:19822-9. 2006
    ..coli uses ChaA to discard excessive K(+), which is toxic for these cells. These results suggest that ChaA K(+)/H(+) antiporter activity enables E. coli to adapt to K(+) salinity stress and to maintain K(+) homeostasis...
  23. ncbi Mutations in Mycobacterium tuberculosis Rv0444c, the gene encoding anti-SigK, explain high level expression of MPB70 and MPB83 in Mycobacterium bovis
    Battouli Said-Salim
    McGill University Health Centre, Montreal, QC, Canada
    Mol Microbiol 62:1251-63. 2006
    ..Together these findings indicate that Rv0444c encodes the regulator of SigK (RskA) and mutations in this gene explain high-level MPT70/MPT83 expression by certain MTC members...
  24. ncbi Mycothiol-dependent proteins in actinomycetes
    Mamta Rawat
    Department of Biology, California State University Fresno, Fresno, California 93704, USA
    FEMS Microbiol Rev 31:278-92. 2007
    ..Following a little over a decade of research since the discovery of mycothiol in 1994, we summarize the current knowledge about the role of mycothiol as an enzyme cofactor and consider possible mycothiol-dependent enzymes...
  25. ncbi [Asparaginase mediated acid adaptation of mycobacteria]
    Xiaolang Cai
    College of Animal Science and Technology, Zhejiang Agriculture and Forestry University, Lin an 311300, China
    Wei Sheng Wu Xue Bao 52:1467-76. 2012
    ..To elucidate the acid adaptation mechanism mediated by the asparagine (Asn) metabolic pathway, the activity of asparaginase (AnsA) and growth of mycobacteria were characterized...
  26. doi Crystal structure and functional implications of LprF from Mycobacterium tuberculosis and M. bovis
    Jin Sik Kim
    College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Republic of Korea
    Acta Crystallogr D Biol Crystallogr 70:2619-30. 2014
    ..smegmatis. These observations suggested that LprF transfers the diacylated glycolipid from the plasma membrane to the cell wall, which might be related to the pathogenesis of the bacteria. ..
  27. doi Comparative study of the growth and survival of recombinant Mycobacterium smegmatis expressing Mce4A and Mce4E from Mycobacterium bovis
    Liu He
    1 The State Key Lab of Agrobiotechnology, Key Lab of Animal Epidemiology and Zoonosis Ministry of Agriculture, National TSE Lab, College of Veterinary Medicine, China Agricultural University, Beijing, People s Republic of China
    DNA Cell Biol 34:125-32. 2015
    ..Conclusively, the different performances of the recombinant strains suggest that the Mce4A and Mce4E proteins enhance mycobacterial adaptation to the harsh environment within macrophages after phagocytosis. ..
  28. pmc High throughput phenotypic analysis of Mycobacterium tuberculosis and Mycobacterium bovis strains' metabolism using biolog phenotype microarrays
    Bhagwati Khatri
    Animal Health Veterinary Laboratories Weybridge, Department for Bovine Tuberculosis, New Haw, Surrey, United Kingdom
    PLoS ONE 8:e52673. 2013
    ..This study proved principle that Phenotype MicroArrays can be used with slow-growing pathogenic mycobacteria and already has generated interesting data worthy of further investigation...
  29. pmc Cloning and expression of the gene for the Avi-3 antigen of Mycobacterium avium and mapping of its epitopes
    R Yamaguchi
    Central Research Laboratories, Ajinomoto Co, Inc, Kawasaki, Japan
    Infect Immun 60:1210-6. 1992
    ..This mapping method would be useful in the development of a subunit vaccine consisting of an immunodominant B-cell epitope linked to a T-cell epitope in the vicinity...
  30. ncbi Molecular cloning, characterization and purification of ornithine carbamoyltransferase from Mycobacterium bovis BCG
    J Timm
    Service de Genetique Appliquee, Universite Libre de Bruxelles, Nivelles Belgium
    Mol Gen Genet 234:475-80. 1992
    ..The native enzyme has an estimated molecular mass of 110 kDa, suggesting a trimeric structure as is the case for most of the anabolic OTCases known from various organisms...
  31. ncbi Identification of an insertion sequence, IS1081, in Mycobacterium bovis
    D M Collins
    Central Animal Health Laboratory, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    FEMS Microbiol Lett 67:11-5. 1991
    ..IS1081 may be useful for genetic manipulations and for developing a diagnostic test for bovine tuberculosis based on the polymerase chain reaction...
  32. ncbi Sequence and immunogenicity of the 70-kDa heat shock protein of Mycobacterium leprae
    K R McKenzie
    Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, Australia
    J Immunol 147:312-9. 1991
    ..leprae recombinant proteins were lower than to mAb affinity-purified BCG p70. Thus, the M. leprae 70-kDa heat shock protein elicits T and B cell responses in subjects exposed to mycobacteria, despite its homology with the human hsp70...
  33. ncbi Cloning and characterization of the gene for the '19 kDa' antigen of Mycobacterium bovis
    M E Collins
    Department of Microbiology, University of Surrey, Guildford, UK
    J Gen Microbiol 136:1429-36. 1990
    ..This sequence is identical to that, independently determined, of a gene from M. tuberculosis, usually referred to as the 19 kDa antigen. The reasons for the apparent size discrepancies are discussed...
  34. pmc Cloning and characterization of the gene for immunogenic protein MPB64 of Mycobacterium bovis BCG
    R Yamaguchi
    Central Research Laboratories, Ajinomoto Co, Inc, Kawasaki, Japan
    Infect Immun 57:283-8. 1989
    ..The strict specificity of MPB64 could be applied to immunodiagnosis of tuberculosis...
  35. ncbi Immunogenic protein MPB57 from Mycobacterium bovis BCG: molecular cloning, nucleotide sequence and expression
    R Yamaguchi
    Central Research Laboratories, Ajinomoto Co Inc, Kawasaki, Japan
    FEBS Lett 240:115-7. 1988
    ..This cloned gene was expressed in an Escherichia coli expression vector to give a mature protein which reacted with a polyclonal antibody raised against MPB57...
  36. pmc Properties of proteins MPB64, MPB70, and MPB80 of Mycobacterium bovis BCG
    M Harboe
    Infect Immun 52:293-302. 1986
    ....
  37. ncbi Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis
    T M Wilson
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Mol Microbiol 15:1009-15. 1995
    ..Integration of a functional katG gene into the most resistant strain restored full virulence. This clearly established that katG is a virulence factor for M. bovis and that mutation of the inhA gene has no effect on virulence...
  38. ncbi Cloning and nucleotide sequence of the gene cluster encoding ribosomal proteins S12 and S7 from Mycobacterium bovis BCG
    S Iwanaga
    Laboratory of Biochemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biochem Mol Biol Int 36:209-18. 1995
    ..However, the intercistronic region between S12 and S7 genes, which plays an important role for autoregulation for the str operon in E. coli, is completely absent in M. bovis...
  39. ncbi Characterization of the gene encoding the MPB51, one of the major secreted protein antigens of Mycobacterium bovis BCG, and identification of the secreted protein closely related to the fibronectin binding 85 complex
    N Ohara
    School of Dentistry, Nagasaki University, Japan
    Scand J Immunol 41:433-42. 1995
    ..Two-dimensional electrophoresis of culture fluids of BCG and Western blotting indicated the existence of the other novel protein(s) which strongly cross-reacted with the alpha antigen (85B) and MPB51...
  40. ncbi Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis
    B Heym
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    Mol Microbiol 15:235-45. 1995
    ..The second group comprises a frequently occurring amino acid substitution and a single mutation that are both located in the C-terminal domain but do not noticeably alter either enzyme activity or heat stability...
  41. ncbi Characterization of RNA polymerase and two sigma-factor genes from Mycobacterium smegmatis
    M Predich
    Department of Microbiology, Public Health Research Institute, New York, New York 10016, USA
    Mol Microbiol 15:355-66. 1995
    ..We also demonstrated in vitro transcription of the M. smegmatis rrnB promoter by the M. smegmatis RNA polymerase. Significantly, highly active B. subtilis RNA polymerase holoenzyme was unable to transcribe this gene...
  42. pmc Characterization of a novel Mycobacterium bovis secreted antigen containing PGLTS repeats
    F Bigi
    Instituto de Biologia Molecular, Centro de Investigaciones en Ciencias Veterinarias CICV Instituto Nacional de Tecnología Agropecuaria INTA, Moron, Argentina
    Infect Immun 63:2581-6. 1995
    ..The homology among the M. leprae 28-kDa protein, the protein described in this article, and a recently described M. tuberculosis protein suggests the existence of a new protein family in mycobacteria...
  43. ncbi Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice
    P Andersen
    Department of Bacterial Vaccine, Statens Seruminstitut, Copenhagen, Denmark
    J Immunol 154:3359-72. 1995
    ..ESAT-6 was biochemically purified, characterized, and the gene encoding the protein was cloned...
  44. pmc Cloning and sequence analysis of the rpsL and rpsG genes of Mycobacterium smegmatis and characterization of mutations causing resistance to streptomycin
    T J Kenney
    Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322
    J Bacteriol 176:6153-6. 1994
    ..Forty-six percent of the mutations (13 of 28) were due to a transition changing an AAG Lys codon to an AGG Arg codon, with eight changes at codon 43 and five at codon 88...
  45. pmc The uraA locus and homologous recombination in Mycobacterium bovis BCG
    A Aldovini
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    J Bacteriol 175:7282-9. 1993
    ..These results have implications for understanding the role of mycobacterial genes in disease pathogenesis and for the genetic engineering of improved mycobacterial vaccines...
  46. ncbi Sequence and expression of the Mycobacterium leprae dnaJ gene
    S S Harvey
    Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, NSW, Australia
    J Gen Microbiol 139:2003-8. 1993
    ..leprae and M. tuberculosis (89%) with significant divergence between the two occurring only at the C-terminal end. The expressed recombinant DnaJ protein had a molecular mass of 42 kDa...
  47. ncbi inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
    A Banerjee
    Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461
    Science 263:227-30. 1994
    ..These results suggest that InhA is likely a primary target of action for INH and ETH...
  48. ncbi Isolation and amino acid sequence of the 30S ribosomal protein S19 from Mycobacterium bovis BCG
    N Ohara
    Nagasaki University, School of Dentistry, Japan
    FEBS Lett 331:9-14. 1993
    ..coli, and B. stearothermophilus, respectively; 33% of the residues of MboS19 were identical to those in the archaebacterial ribosomal protein HmaS19...
  49. ncbi Mycobacterium smegmatis DNA gyrase: cloning and overexpression in Escherichia coli
    K Madhusudan
    Centre for Genetic Engineering, Indian Institute of Science, Bangalore, India
    Microbiology 141:3029-37. 1995
    ..This activity was ATP-dependent and novobiocin-sensitive. The identity of the genes was also confirmed by complementation analysis...
  50. ncbi Overproduction of mycobacterial ribosomal protein S13 induces catalase/peroxidase activity and hypersensitivity to isoniazid in Mycobacterium smegmatis
    E Dubnau
    Public Health Research Institute, Tuberculosis Center, New York, NY 10016, USA
    Gene 170:17-22. 1996
    ..The overproduction of S13 may induce a stress response, resulting in increased expression of katG (encoding Kat/Prx) in Ms, thereby causing hypersensitivity to INH...
  51. ncbi ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex
    T M Wilson
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Mol Microbiol 19:1025-34. 1996
    ..Increased expression of AhpC may account for some of the INH resistance of strains of the M. tuberculosis complex...
  52. ncbi Characterisation of a lipoprotein in Mycobacterium bovis (BCG) with sequence similarity to the secreted protein MPB70
    W Vosloo
    Department of Medical Microbiology, University of Cape Town and Groote Schuur Hospital, Western Cape Province, South Africa
    Gene 188:123-8. 1997
    ..Furthermore, only two out of six of the Mb field isolates produced detectable antigen, indicating that expression of the mpb83 gene is variable within the Mt complex organisms...
  53. ncbi Molecular cloning of the leuB genes from Mycobacterium bovis BCG and Mycobacterium tuberculosis
    M Y Han
    Molecular Cellular Biology Research Division, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea
    Biochem Mol Biol Int 41:657-63. 1997
    ..011 bp encoding isopropylmalate dehydrogenase with a calculated molecular weight of 42 kDa. The leuB gene of Mycobacterium tuberculosis isolated from Korean tuberculosis patient is shown to be identical to that of BCG except one bp...
  54. ncbi Inactivation of the 20S proteasome in Mycobacterium smegmatis
    N Knipfer
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Microbiol 25:375-83. 1997
    ..smegmatis cells lacking intact proteasome genes are viable and phenotypically indistinguishable from congenic strains containing proteasomes. Implications for the evolution of the protein turnover apparatus are discussed...
  55. ncbi A novel 27 kDa lipoprotein antigen from Mycobacterium bovis
    F Bigi
    Instituto de Biotecnologia, CICV INTA, Castelar, Argentina
    Microbiology 143:3599-605. 1997
    ..bovis/M. tuberculosis has been identified. The results presented here and elsewhere suggest that mycobacterial lipoproteins should be considered in the design of new recombinant vaccines and diagnostic methods...
  56. ncbi The role of ribosomal RNAs in macrolide resistance
    P Sander
    Institut fur Medizinische Mikrobiologie, Medizinische Hochschule Hannover, Germany Boettger Erik Mh Hannover de
    Mol Microbiol 26:469-80. 1997
    ..recessivity and gene dosage effects in eubacterial ribosomal nucleic acids to be addressed experimentally in vivo...
  57. pmc NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis
    L Miesel
    Department of Microbiology and Immunology, Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Bacteriol 180:2459-67. 1998
    ..tuberculosis complex. The genetic data presented here indicate that defects in NADH oxidation cause all of the mutant traits and that an increase in the NADH/NAD+ ratio confers INH resistance...
  58. pmc Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum
    E Pagan-Ramos
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
    J Bacteriol 180:4856-64. 1998
    ..marinum will be useful as a model system for studying the role of oxidative stress response in mycobacterial physiology, intracellular survival, and other host-pathogen interactions associated with mycobacterial diseases...
  59. ncbi Crystal structure of the iron-dependent regulator (IdeR) from Mycobacterium tuberculosis shows both metal binding sites fully occupied
    E Pohl
    Departments of Biological Structure and Biochemistry, Biomolecular Structure Center
    J Mol Biol 285:1145-56. 1999
    ..The mechanism by which metal binding may cause these structural changes between apo and holo wild-type repressor is discussed...
  60. ncbi Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate
    D A Rozwarski
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 274:15582-9. 1999
    ..The substrate binding loop of InhA is longer than that of other enoyl-ACP reductases and creates a deeper substrate binding crevice, consistent with the ability of InhA to recognize longer chain fatty acyl substrates...
  61. pmc A cooperative oxygen-binding hemoglobin from Mycobacterium tuberculosis
    M Couture
    Department of Biochemistry, Faculty of Sciences and Engineering, Laval University, Quebec, QC Canada G1K 7P4
    Proc Natl Acad Sci U S A 96:11223-8. 1999
    ..The results suggest that, physiologically, the primary role of HbN may be to protect the bacilli against reactive nitrogen species produced by the host macrophage...
  62. ncbi Decreased capacity of recombinant 45/47-kDa molecules (Apa) of Mycobacterium tuberculosis to stimulate T lymphocyte responses related to changes in their mannosylation pattern
    C Horn
    Unité de Physiopathologie de l Infection, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 274:32023-30. 1999
    ..Thus the observed biological effects were related to the extent of glycosylation of the antigen...
  63. ncbi Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III
    J N Scarsdale
    Department of Biochemistry, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia 23219, USA
    J Biol Chem 276:20516-22. 2001
    ..This mtFabH presents a new target for structure-based design of novel antimycobacterial agents...
  64. ncbi The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination
    K Pethe
    Unité INSERM U447, Institut Pasteur de Lille, 1 rue du Prof Calmette, F 59019 Lille cedex, France
    Nature 412:190-4. 2001
    ..They also suggest that antibody responses to HBHA may add to immune protection against tuberculosis...
  65. ncbi Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv
    A Gupta
    Molecular and Structural Biology Division, Central Drug Research Institute, Chattar Manzil Palace, Mahatma Gandhi Marg, Lucknow 226001, India
    J Mol Biol 312:381-91. 2001
    ..Structure analysis and homology to yeast Gcd14p suggest that Rv2118c could be an RNA methyltransferase, but further studies are required to establish its functional role conclusively...
  66. pmc Mycobacterium tuberculosis signal transduction system required for persistent infections
    T C Zahrt
    Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Science Building II, Ann Arbor, MI 48109 0620, USA
    Proc Natl Acad Sci U S A 98:12706-11. 2001
    ..tuberculosis H37Rv growth in vivo in an organ- and infection stage-specific fashion. These results indicate that two-component systems are important for adaptation of the tubercle bacillus during stages of persistent infection...
  67. pmc Two nonredundant SecA homologues function in mycobacteria
    M Braunstein
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Bacteriol 183:6979-90. 2001
    ..This finding, in combination with the fact that SecA2 is highly conserved throughout mycobacteria, suggests a second role for SecA2. The possibility exists that another role for SecA2 is to export a specific subset of proteins...
  68. ncbi Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis
    Chih Chin Huang
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    J Biol Chem 277:11559-69. 2002
    ..These structures provide a foundation for rational-drug design, which may lead to the development of new inhibitors effective against persistent bacteria...
  69. ncbi Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis
    Yoonsang Cho
    Department of Biochemistry and Biophysics, Texas A and M University, College Station 77843 2128, USA
    J Biol Chem 278:8333-9. 2003
    ..The inhibitor AMP binds in the active site cavity formed between the two catalytic domains. A model for the mechanism of allosteric inhibition has been derived from conformational differences between the AMP:His-bound and apo structures...
  70. ncbi Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase
    Andrzej Lewandowicz
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:6057-66. 2003
    ..This approach has resulted in the highest affinity transition state analogues known for MtPNP...
  71. ncbi The crystal structure of the first enzyme in the pantothenate biosynthetic pathway, ketopantoate hydroxymethyltransferase, from M tuberculosis
    Barnali N Chaudhuri
    UCLA Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Structure 11:753-64. 2003
    ..The apparent conservation of certain detailed structural characteristics suggests that KPHMT is distantly related by divergent evolution to enzymes in unrelated pathways, including isocitrate lyase and phosphoenolpyruvate mutase...
  72. pmc Functional analysis of the Mycobacterium tuberculosis MprAB two-component signal transduction system
    Thomas C Zahrt
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Infect Immun 71:6962-70. 2003
    ..tuberculosis physiology and pathogenesis. Characterization of two-component signal transduction systems will enhance our understanding of processes regulated by M. tuberculosis during acute and/or persistent infection in the host...
  73. pmc rpoB-based identification of nonpigmented and late-pigmenting rapidly growing mycobacteria
    Toidi Adekambi
    Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    J Clin Microbiol 41:5699-708. 2003
    ..We conclude that molecular identification by analysis of the 723-bp rpoB sequence is a rapid and accurate tool for identification of RGM...
  74. ncbi The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases
    Rosalind A Wilson
    School of Biosciences, The University of Birmingham, Edgabston, Birmingham B15 2TT, UK
    J Mol Biol 335:519-30. 2004
    ....
  75. ncbi Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft
    Barnali N Chaudhuri
    UCLA Department of Energy Institute for Genomics and Proteomics, Los Angeles, California 90095, USA
    J Biol Chem 279:24585-91. 2004
    ..Our structural data furthers the previously proposed mechanism of tRNA recognition. The present crystal structure emphasizes the significant role that protein dynamics must play in tRNA recognition, base flipping, and modification...
  76. ncbi Protein kinase G from pathogenic mycobacteria promotes survival within macrophages
    Anne Walburger
    Biozentrum, University of Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
    Science 304:1800-4. 2004
    ....
  77. ncbi Characterization of Mycobacterium tuberculosis NAD kinase: functional analysis of the full-length enzyme by site-directed mutagenesis
    Nadia Raffaelli
    Istituto di Biotecnologie Biochimiche, Universita Politecnica delle Marche, Via Ranieri, 60131 Ancona, Italy
    Biochemistry 43:7610-7. 2004
    ....
  78. ncbi A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis
    Silvia Garavaglia
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche, Farmacologiche Istituto Nazionale Fisica della Materia, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    J Biol Chem 279:40980-6. 2004
    ..The conserved GGDG structural fingerprint of the catalytic site is reminiscent of the related region in 6-phosphofructokinase, supporting the hypothesis that NAD kinase belongs to a newly reported superfamily of kinases...
  79. ncbi A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites
    Rajan Sankaranarayanan
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
    Nat Struct Mol Biol 11:894-900. 2004
    ..This first bacterial type III PKS structure underlines a fascinating example of the way in which subtle changes in protein architecture can generate metabolite diversity in nature...
  80. ncbi The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis
    J Preben Morth
    EMBL Hamburg Outstation, c o DESY, Notkestrasse 85, Germany
    Structure 12:1595-605. 2004
    ....
  81. ncbi CFP10 discriminates between nonacetylated and acetylated ESAT-6 of Mycobacterium tuberculosis by differential interaction
    Limei Meng Okkels
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Proteomics 4:2954-60. 2004
    ..This example shows that the access to the protein species level can be a prerequisite to understand regulation of protein-protein interaction...
  82. ncbi Identification of genetic markers for Mycobacterium pinnipedii through genome analysis
    Fabiana Bigi
    Institute of Biotechnology, CICVyA INTA, 1712 Castelar, Argentina
    FEMS Microbiol Lett 248:147-52. 2005
    ..Interestingly, a deletion overlapping the previously described RD2 region was identified in some isolates of Mycobacterium microti and further characterised...
  83. ncbi Expression of the PE_PGRS 33 protein in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survival
    Veerabadran Dheenadhayalan
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29, Room 503, HFM 431, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Microbes Infect 8:262-72. 2006
    ....
  84. pmc Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense
    Peter Sperisen
    Swiss Institute of Bioinformatics, Epalinges, Switzerland
    PLoS Comput Biol 1:e63. 2005
    ..At a more basic level, the characterization of the molecular and cellular function of Stealth proteins may shed light on fundamental mechanisms of innate immune defense against microbial invasion...
  85. ncbi The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis
    Jesús Gonzalo Asensio
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, C Domingo Miral sin numero, 50009 Zaragoza, Spain
    J Biol Chem 281:1313-6. 2006
    ..This work represents an important step toward the functional characterization of PhoP-PhoR and the understanding of complex lipid synthesis in M. tuberculosis...
  86. doi Mycobacterium tuberculosis ClpC1: characterization and role of the N-terminal domain in its function
    Narayani P Kar
    Immunochemistry Laboratory, National Institute of Immunology, New Delhi, India
    FEBS J 275:6149-58. 2008
    ..Also, an exposed repeat II makes the protein more stable and functionally more active...
  87. ncbi [Design and construction of the platform for comparative genomics]
    Na Liu
    Institute of Bioinformatics, School of Basic Medical Science, College of Biotechnology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:219-23. 2010
    ..To design a versatile genome comparison and visualization platform based on browser/server mode supported by a local server...
  88. doi Protein kinase A and protein kinase C(alpha)/PPP1CC2 play opposing roles in the regulation of phosphatidylinositol 3-kinase activation in bovine sperm
    T Rotman
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Reproduction 140:43-56. 2010
    ..This degradation is mediated by PRKA, indicating that in addition to the direct activation of PI3K by PRKA, this kinase can enhance PI3K phosphorylation indirectly by enhancing the degradation and inactivation of PRKCA and PPP1CC2...
  89. doi Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9
    Mark A Chambers
    TB Research Group, Department of Bacteriology, Veterinary Laboratories Agency Weybridge, Addlestone, Surrey KT15, UK
    Biochem Biophys Res Commun 400:403-8. 2010
    ..Direct interaction of RecMPB83 with TLR2 was demonstrated by surface plasmon-resonance. MPB83 may act as a virulence factor through TLR2 mediated induction of MMP-9...
  90. doi The use of Streptomyces for immunization against mycobacterial infections
    Nesty Olivares Arzuaga
    Finlay Institute, Research Center Vaccine Production and Serum, Habana, Cuba
    Hum Vaccin 7:934-40. 2011
    ..These observations, along with Streptomyces' potential for expressing foreign proteins, suggest that Streptomyces could be an advantageous vector in the design of new tuberculosis vaccines...
  91. ncbi Detection and identification of mycobacteria by amplification of mycobacterial DNA
    A J Hance
    INSERM U 82, Faculte Xavier Bichat, Paris, France
    Mol Microbiol 3:843-9. 1989
    ..These results suggest that this approach may prove useful in the early diagnosis of mycobacterial infection...
  92. ncbi Epitope mapping of the Mycobacterium bovis secretory protein MPB70 using overlapping peptide analysis
    A J Radford
    Commonwealth Scientific and Industrial Research Organization, Division of Animal Health, Parkville, Victoria
    J Gen Microbiol 136:265-72. 1990
    ....
  93. pmc Nucleotide sequence of the 32 kDa-protein gene (antigen 85 A) of Mycobacterium bovis BCG
    L De Wit
    Institut Pasteur du Brabant, Department of Virology, Brussels, Belgium
    Nucleic Acids Res 18:3995. 1990
  94. pmc Cloning and expression of the Mycobacterium bovis BCG gene for extracellular alpha antigen
    K Matsuo
    Central Research Laboratories of Ajinomoto Co Inc, Kawasaki City, Japan
    J Bacteriol 170:3847-54. 1988
    ..coli expression vector. This protein, which reacted with polyclonal antibody raised against alpha antigen from Mycobacterium tuberculosis, would be applicable to the immunodiagnosis of tuberculosis...
  95. ncbi Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guérin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA
    D L Rainwater
    J Biol Chem 260:616-23. 1985
    ..It is concluded that the mycocerosic acid synthase is a multifunctional enzyme similar to the well-characterized multifunctional fatty acid synthases except for the substrate specificity...
  96. ncbi Differential transcription of the MPB70 genes in two major groups of Mycobacterium bovis BCG substrains
    T Matsuo
    Department of Oral Microbiology, School of Dentistry, Nagasaki University, Japan
    Microbiology 141:1601-7. 1995
    ..On the basis of these results, the difference in the secretion of the MPB70 protein between BCG Tokyo and Pasteur was attributed to differential transcription efficiencies...
  97. ncbi Amplification and cloning of the Mycobacterium tuberculosis dnaA gene
    M Rajagopalan
    Department of Microbiology, University of Texas Health Center at Tyler 75710, USA
    Gene 163:75-9. 1995
    ..Furthermore, a 5-kb DNA fragment containing the Mt dnaA was subcloned into a pUC18 vector...
  98. ncbi Isolation and characterization of the aspartokinase and aspartate semialdehyde dehydrogenase operon from mycobacteria
    J D Cirillo
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461
    Mol Microbiol 11:629-39. 1994
    ..Primer extension analysis revealed that the only transcriptional start in this region is found 5' of the ask gene. This observation indicates that the mycobacterial ask and asd genes are in an operon...
  99. pmc Streptomycin resistance in mycobacteria
    N Honore
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    Antimicrob Agents Chemother 38:238-42. 1994
    ..avium, M. gordonae, and M. szulgai, that are naturally resistant to streptomycin. This suggests that permeability barriers may be responsible for the resistance to the antibiotic...
  100. pmc Cloning and sequencing of the gene encoding the ribosomal L7/L12-like protein of Mycobacterium bovis BCG
    N Ohara
    School of Dentistry, Nagasaki University, Japan
    Nucleic Acids Res 21:3579. 1993
  101. pmc Nucleotide sequence analysis of the ribosomal S12 gene of Mycobacterium intracellulare
    J Nair
    Laboratory of Mycobacteria, US Food and Drug Administration, Bethesda, MD 20892
    Nucleic Acids Res 21:1039. 1993

Research Grants1

  1. Identification of M. tuberculosis Protein Secreted During Growth in Macrophages
    Miriam Braunstein; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..

Patents11

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  5. Lipid metabolism proteins, combinations of lipid metabolism proteins and uses thereof
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  9. Process for the control of production of fine chemicals
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  10. GENETIC VACCINE AGAINST INTRACELLULAR PARASITIC PATHOGENS
    Patent Number: WO2004067040-A; Date:2004-08-12
  11. Process for the production of a fine chemical
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