Corynebacterium glutamicum ATCC 13032

Summary

Alias: Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032

Top Publications

  1. Tauch A, Hermann T, Burkovski A, Kr mer R, P hler A, Kalinowski J. Isoleucine uptake in Corynebacterium glutamicum ATCC 13032 is directed by the brnQ gene product. Arch Microbiol. 1998;169:303-12 pubmed
    ..6-kb HindIII-StuI fragment of Corynebacterium glutamicum ATCC 13032, located downstream of the aecD gene, encodes an isoleucine uptake system...
  2. Brand S, Niehaus K, P hler A, Kalinowski J. Identification and functional analysis of six mycolyltransferase genes of Corynebacterium glutamicum ATCC 13032: the genes cop1, cmt1, and cmt2 can replace each other in the synthesis of trehalose dicorynomycolate, a component of the mycolic acid lay. Arch Microbiol. 2003;180:33-44 pubmed publisher
    By data mining in the sequence of the Corynebacterium glutamicum ATCC 13032 genome, six putative mycolyltransferase genes were identified that code for proteins with similarity to the N-terminal domain of the mycolic acid transferase PS1 ..
  3. Koch D, R ckert C, Rey D, Mix A, P hler A, Kalinowski J. Role of the ssu and seu genes of Corynebacterium glutamicum ATCC 13032 in utilization of sulfonates and sulfonate esters as sulfur sources. Appl Environ Microbiol. 2005;71:6104-14 pubmed publisher
    b>Corynebacterium glutamicum ATCC 13032 was found to be able to utilize a broad range of sulfonates and sulfonate esters as sulfur sources...
  4. Birch H, Alderwick L, Bhatt A, Rittmann D, Krumbach K, Singh A, et al. Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferase. Mol Microbiol. 2008;69:1191-206 pubmed publisher
    ..This newly discovered glycosyltransferase sheds further light on the complexities of Mycobacterium cell wall biosynthesis, such as in M. tuberculosis and related species and represents a potential new drug target...
  5. Sch fer A, Schwarzer A, Kalinowski J, P hler A. Cloning and characterization of a DNA region encoding a stress-sensitive restriction system from Corynebacterium glutamicum ATCC 13032 and analysis of its role in intergeneric conjugation with Escherichia coli. J Bacteriol. 1994;176:7309-19 pubmed
    ..transfer of mobilizable plasmids in intergeneric conjugation of Escherichia coli donors with Corynebacterium glutamicum ATCC 13032 is severely affected by a restriction system in the recipient that can be inactivated by a variety ..
  6. Gande R, Gibson K, Brown A, Krumbach K, Dover L, Sahm H, et al. Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. J Biol Chem. 2004;279:44847-57 pubmed
    ..This study illustrates that the high number of accD paralogs have evolved to represent specific variations on the well known basic theme of providing carboxylated intermediates in lipid biosynthesis. ..
  7. Meniche X, Labarre C, de Sousa d Auria C, Huc E, Laval F, Tropis M, et al. Identification of a stress-induced factor of Corynebacterineae that is involved in the regulation of the outer membrane lipid composition. J Bacteriol. 2009;191:7323-32 pubmed publisher
    ..We therefore propose to name this protein family the envelope lipids regulation factor (ElrF) family. ..
  8. Tan Z, Zhao J, Chen J, Rao D, Zhou W, Chen N, et al. Enhancing thermostability and removing hemin inhibition of Rhodopseudomonas palustris 5-aminolevulinic acid synthase by computer-aided rational design. Biotechnol Lett. 2019;41:181-191 pubmed publisher
    ..27% for wild-type). The ALA titer was increased by 6% and 22% in fermentation using Corynebacterium glutamicum ATCC 13032 expressing H29R and H15K, respectively...
  9. Baumgart M, Frunzke J. The manganese-responsive regulator MntR represses transcription of a predicted ZIP family metal ion transporter in Corynebacterium glutamicum. FEMS Microbiol Lett. 2015;362:1-10 pubmed publisher
    ..In this study, we characterized the DtxR-type transcriptional regulator MntR (cg0741) of Corynebacterium glutamicum ATCC 13032 as a manganese-dependent repressor of the predicted ZIP family metal transporter Cg1623...

More Information

Publications160 found, 100 shown here

  1. Abreu V, Almeida S, Tiwari S, Hassan S, Mariano D, Silva A, et al. CMRegNet-An interspecies reference database for corynebacterial and mycobacterial regulatory networks. BMC Genomics. 2015;16:452 pubmed publisher
    ..In this work, we present a new database, CMRegNet for the gene regulatory networks of Corynebacterium glutamicum ATCC 13032 and Mycobacterium tuberculosis H37Rv...
  2. Deng Y, Mao Y, Zhang X. Metabolic engineering of a laboratory-evolved Thermobifida fusca muC strain for malic acid production on cellulose and minimal treated lignocellulosic biomass. Biotechnol Prog. 2016;32:14-20 pubmed publisher
    ..was redirected to oxaloacetate by expressing an exogenous pyruvate carboxylase (PCx) gene from Corynebacterium glutamicum ATCC 13032 in the chromosome of T. fusca muC-16...
  3. Walter F, Grenz S, Ortseifen V, Persicke M, Kalinowski J. Corynebacterium glutamicum ggtB encodes a functional γ-glutamyl transpeptidase with γ-glutamyl dipeptide synthetic and hydrolytic activity. J Biotechnol. 2016;232:99-109 pubmed publisher
    ..the role of γ-glutamyl transpeptidase in the metabolism of γ-glutamyl dipeptides produced by Corynebacterium glutamicum ATCC 13032 was studied...
  4. Li Y, Cong H, Liu B, Song J, Sun X, Zhang J, et al. Metabolic engineering of Corynebacterium glutamicum for methionine production by removing feedback inhibition and increasing NADPH level. Antonie Van Leeuwenhoek. 2016;109:1185-97 pubmed publisher
    ..In this study, Corynebacterium glutamicum ATCC 13032 was metabolically engineered for methionine production...
  5. Yomantas Y, Abalakina E, Lobanova J, Mamontov V, Stoynova N, Mashko S. Complete nucleotide sequences and annotations of ?673 and ?674, two newly characterised lytic phages of Corynebacterium glutamicum ATCC 13032. Arch Virol. 2018;: pubmed publisher
    The genomes of two new lytic phages of Corynebacterium glutamicum ATCC 13032, ?673 and ?674, were sequenced and annotated (GenBank: MG324353, MG324354)...
  6. Kobayashi M, Asai Y, Hatakeyama K, Kijima N, Wachi M, Nagai K, et al. Cloning, sequencing, and characterization of the ftsZ gene from coryneform bacteria. Biochem Biophys Res Commun. 1997;236:383-8 pubmed publisher
    ..Expression of Br. flavum ftsZ gene in E. coli, JM109 inhibited its cell division, leading to filamentation. This suggested that the Br. flavum ftsZ product competed with the E. coli ftsZ product...
  7. Wehmeier L, Sch fer A, Burkovski A, Kr mer R, Mechold U, Malke H, et al. The role of the Corynebacterium glutamicum rel gene in (p)ppGpp metabolism. Microbiology. 1998;144 ( Pt 7):1853-62 pubmed publisher
    ..strategy using degenerate consensus oligonucleotides was applied to isolate the rel gene of Corynebacterium glutamicum ATCC 13032. The gene consists of 2283 nucleotides and encodes a protein of 760 amino acids with a molecular ..
  8. Razak M, Viswanath B. Comparative studies for the biotechnological production of L-Lysine by immobilized cells of wild-type Corynebacterium glutamicum ATCC 13032 and mutant MH 20-22 B. 3 Biotech. 2015;5:765-774 pubmed publisher
    ..optimization and upstream bioprocess analysis for the production of lysine by immobilized cells of Corynebacterium glutamicum ATCC 13032 and MH 20-22 B in stirred tank bioreactor...
  9. Sidhu N, Delbaere L, Sheldrick G. Structure of a highly NADP+-specific isocitrate dehydrogenase. Acta Crystallogr D Biol Crystallogr. 2011;67:856-69 pubmed publisher
    ..It is possible that the small-molecule concerted inhibitors glyoxylate and oxaloacetate similarly bind close to the hinge, leading to an inactive conformation of the enzyme. ..
  10. Molenaar D, van der Rest M, Petrovi S. Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum. Eur J Biochem. 1998;254:395-403 pubmed
    ..The derived protein sequence is similar to hypothetical proteins from Escherichia coli, Klebsiella pneumoniae, and Mycobacterium tuberculosis...
  11. Grossmann K, Herbster K, Mack M. Rapid cloning of metK encoding methionine adenosyltransferase from Corynebacterium glutamicum by screening a genomic library on a high density colony-array. FEMS Microbiol Lett. 2000;193:99-103 pubmed
    ..glutamicum led to an increased intracellular S-adenosylmethionine concentration. The metK transcript was detected by reverse transcription PCR in C. glutamicum cells in the exponential growth phase but not in the stationary phase. ..
  12. Usuda Y, Tujimoto N, Abe C, Asakura Y, Kimura E, Kawahara Y, et al. Molecular cloning of the Corynebacterium glutamicum ('Brevibacterium lactofermentum' AJ12036) odhA gene encoding a novel type of 2-oxoglutarate dehydrogenase. Microbiology. 1996;142 ( Pt 12):3347-54 pubmed
    ..It suggests that the C. glutamicum odhA gene might encode a novel bifunctional protein with E1o and E2o activities. ..
  13. Mishra A, Krumbach K, Rittmann D, Appelmelk B, Pathak V, Pathak A, et al. Lipoarabinomannan biosynthesis in Corynebacterineae: the interplay of two ?(1?2)-mannopyranosyltransferases MptC and MptD in mannan branching. Mol Microbiol. 2011;80:1241-59 pubmed publisher
    ..Overall, our study enhances our understanding of complex lipoglycan biosynthesis in Corynebacterineae and sheds further light on the structural and functional relationship of these classes of polysaccharides...
  14. Siewe R, Weil B, Burkovski A, Eikmanns B, Eikmanns M, Kr mer R. Functional and genetic characterization of the (methyl)ammonium uptake carrier of Corynebacterium glutamicum. J Biol Chem. 1996;271:5398-403 pubmed
    ..According to the hydrophobicity profile, it is an integral membrane protein containing 10 or 11 membrane-spanning segments...
  15. Wehmeier L, Brockmann Gretza O, Pisabarro A, Tauch A, P hler A, Martin J, et al. A Corynebacterium glutamicum mutant with a defined deletion within the rplK gene is impaired in (p)ppGpp accumulation upon amino acid starvation. Microbiology. 2001;147:691-700 pubmed publisher
    ..Evidently, the C. glutamicum rplK gene is required for (p)ppGpp accumulation upon nutritional starvation...
  16. Oguiza J, Tao X, Marcos A, Mart n J, Murphy J. Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR homolog from Brevibacterium lactofermentum. J Bacteriol. 1995;177:465-7 pubmed
    ..The extents of induction by increasing concentrations of the chelator 2,2'-dipyridyl were identical in cells expressing DtxR from either C. diphtheriae or B. lactofermentum...
  17. Serebrijski I, Wojcik F, Reyes O, Leblon G. Multicopy suppression by asd gene and osmotic stress-dependent complementation by heterologous proA in proA mutants. J Bacteriol. 1995;177:7255-60 pubmed
    ..The other class of complementing clones carries the C. glutamicum proA gene. Complementation of E. coli proA mutants by the C. glutamicum proA+ gene was optimal at high osmolarity. ..
  18. Peters Wendisch P, Kreutzer C, Kalinowski J, P tek M, Sahm H, Eikmanns B. Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene. Microbiology. 1998;144 ( Pt 4):915-27 pubmed publisher
    ..Inactivation of both the PCx gene and the PEPCx gene in C. glutamicum led additionally to the inability to grow on glucose, indicating that no further anaplerotic enzymes for growth on carbohydrates exist in this organism...
  19. Oehlmann W, Auling G. Ribonucleotide reductase (RNR) of Corynebacterium glutamicum ATCC 13032--genetic characterization of a second class IV enzyme. Microbiology. 1999;145 ( Pt 7):1595-604 pubmed
    ..The authors provide arguments for allocation of the C. glutamicum NrdEF proteins to class IV in the RNR classification scheme of Stubbe & van der Donk (1995) [Chem Biol 2, 793-801]. ..
  20. Mateos L, del Real G, Aguilar A, Martin J. Nucleotide sequence of the homoserine dehydrogenase (thr A) gene of Brevibacterium lactofermentum. Nucleic Acids Res. 1987;15:10598 pubmed
  21. Kallscheuer N, Bott M, van Ooyen J, Polen T. Single-Domain Peptidyl-Prolyl cis/trans Isomerase FkpA from Corynebacterium glutamicum Improves the Biomass Yield at Increased Growth Temperatures. Appl Environ Microbiol. 2015;81:7839-50 pubmed publisher
    ..Comparative transcriptome analysis revealed 69 genes which exhibit ≥2-fold mRNA level changes in C. glutamicum ΔfkpA, giving insight into the transcriptional response upon mild heat stress when FkpA is absent. ..
  22. Sahm H, Eggeling L. D-Pantothenate synthesis in Corynebacterium glutamicum and use of panBC and genes encoding L-valine synthesis for D-pantothenate overproduction. Appl Environ Microbiol. 1999;65:1973-9 pubmed
  23. Hirasawa T, Kumagai Y, Nagai K, Wachi M. A Corynebacterium glutamicum rnhA recG double mutant showing lysozyme-sensitivity, temperature-sensitive growth, and UV-sensitivity. Biosci Biotechnol Biochem. 2003;67:2416-24 pubmed
    ..These suggest that temperature-sensitive growth, UV-sensitivity, and probably lysozyme-sensitivity also, of KY9707 were caused by mutations in the genes encoding RNase HI and RecG. ..
  24. Schoepe J, Niefind K, Schomburg D. 1.6 angstroms structure of an NAD+-dependent quinate dehydrogenase from Corynebacterium glutamicum. Acta Crystallogr D Biol Crystallogr. 2008;D64:803-9 pubmed publisher
    ..The active site of the dehydrogenase reported here is larger than those of other known shikimate/quinate dehydrogenases, which may explain why quinate is easily accommodated within the catalytic cleft. ..
  25. Kautzmann F, Altenbuchner J. Inactivation of genes involved in base excision repair of Corynebacterium glutamicum and survival of the mutants in presence of various mutagens. Arch Microbiol. 2017;199:1043-1054 pubmed publisher
    ..The genome of Corynebacterium glutamicum ATCC 13032 contains various DNA glycosylases encoding genes (ung, fpg/mutM, tagI, alkA, mutY), two AP-..
  26. Reinscheid D, Eikmanns B, Sahm H. Analysis of a Corynebacterium glutamicum hom gene coding for a feedback-resistant homoserine dehydrogenase. J Bacteriol. 1991;173:3228-30 pubmed
    ..Nucleotide sequence analysis revealed a single transition from G to A in homFBR leading to replacement of glycine-378 by glutamate in the mutant homoserine dehydrogenase...
  27. Kalinowski J, Cremer J, Bachmann B, Eggeling L, Sahm H, P hler A. Genetic and biochemical analysis of the aspartokinase from Corynebacterium glutamicum. Mol Microbiol. 1991;5:1197-204 pubmed
    The lysC/asd gene cluster of Corynebacterium glutamicum ATCC 13032 was cloned and sequenced...
  28. Kalinowski J, Bachmann B, Thierbach G, Puhler A. Aspartokinase genes lysC alpha and lysC beta overlap and are adjacent to the aspartate beta-semialdehyde dehydrogenase gene asd in Corynebacterium glutamicum. Mol Gen Genet. 1990;224:317-24 pubmed
    ..glutamicum asd gene complemented Escherichia coli asd mutants. Increase in ASD activity by a factor of 30-60 was measured for C. glutamicum cells harbouring high copy-number plasmids with the C. glutamicum asd gene. ..
  29. Wehrmann A, Morakkabati S, Kr mer R, Sahm H, Eggeling L. Functional analysis of sequences adjacent to dapE of Corynebacterium glutamicum reveals the presence of aroP, which encodes the aromatic amino acid transporter. J Bacteriol. 1995;177:5991-3 pubmed
  30. Wehrmann A, Eggeling L, Sahm H. Analysis of different DNA fragments of Corynebacterium glutamicum complementing dapE of Escherichia coli. Microbiology. 1994;140 ( Pt 12):3349-56 pubmed
    ..coli. The C. glutamicum gene now available is the first gene from the succinylase branch of lysine synthesis of this biotechnologically important organism. ..
  31. Jakoby M, Kr mer R, Burkovski A. Nitrogen regulation in Corynebacterium glutamicum: isolation of genes involved and biochemical characterization of corresponding proteins. FEMS Microbiol Lett. 1999;173:303-10 pubmed
    ..glutamicum is similar to that of the Gram-negative Escherichia coli. As deduced from data base searches, the described regulation may also hold true for the important pathogen Mycobacterium glutamicum...
  32. Garbe T, Kobayashi M, Yukawa H. Indole-inducible proteins in bacteria suggest membrane and oxidant toxicity. Arch Microbiol. 2000;173:78-82 pubmed
    ..A direct indication of membrane derangement in E. coli may be the indole-inducible overproduction of spheroplast protein y (Spy)...
  33. Molenaar D, van der Rest M, Drysch A, Y cel R. Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Corynebacterium glutamicum. J Bacteriol. 2000;182:6884-91 pubmed
    ..Evidence is presented that this cyclic reaction also takes place in vivo. As yet, no phenotype of an mdh deletion alone was observed, which leaves a physiological function for MDH in C. glutamicum obscure...
  34. Kim D, Hwang G, Um J, Cho J. Increased L-ornithine production in Corynebacterium glutamicum by overexpression of a gene encoding a putative aminotransferase. J Mol Microbiol Biotechnol. 2015;25:45-50 pubmed
    ..These results suggest that overexpression of the aminotransferase-encoding NCgl0462 open reading frame plays an unequivocal role in the L-ornithine biosynthetic pathway, with overlapping substrate specificity in C. glutamicum. ..
  35. Tsuge Y, Kudou M, Kawaguchi H, Ishii J, Hasunuma T, Kondo A. FudC, a protein primarily responsible for furfural detoxification in Corynebacterium glutamicum. Appl Microbiol Biotechnol. 2016;100:2685-92 pubmed publisher
    ..Kinetic measurements demonstrated that FudC has a high affinity for furfural but has a narrow substrate range for other aldehydes compared to the protein responsible for furfural reduction in E. coli. ..
  36. Peter H, Bader A, Burkovski A, Lambert C, Kr mer R. Isolation of the putP gene of Corynebacterium glutamicum and characterization of a low-affinity uptake system for compatible solutes. Arch Microbiol. 1997;168:143-51 pubmed
    ..Km values of 7.6 mM for proline and 1.3 mM for sodium as cotransported ion were determined. Deletion of the putP gene allowed the functional characterization of another proline uptake system with low affinity...
  37. Patek M, Hochmannová J, Jelinkova M, Nesvera J, Eggeling L. Analysis of the leuB gene from Corynebacterium glutamicum. Appl Microbiol Biotechnol. 1998;50:42-7 pubmed
    ..2 kb in size). Activity of the leuB promoter was significantly reduced when leucine was present in the growth medium. This suggests the negative regulation of the leuB expression on the transcriptional level in C. glutamicum cells. ..
  38. Reinscheid D, Schnicke S, Rittmann D, Zahnow U, Sahm H, Eikmanns B. Cloning, sequence analysis, expression and inactivation of the Corynebacterium glutamicum pta-ack operon encoding phosphotransacetylase and acetate kinase. Microbiology. 1999;145 ( Pt 2):503-13 pubmed publisher
  39. Hwang B, Kim Y, Kim H, Hwang H, Kim J, Lee H. Analysis of Corynebacterium glutamicum methionine biosynthetic pathway: isolation and analysis of metB encoding cystathionine gamma-synthase. Mol Cells. 1999;9:300-8 pubmed
    ..The growth rate of the mutant strain was also comparable to that of the parental strain. These data indicate that, in addition to the transsulfuration pathway, other methionine biosynthetic pathways may be present in C. glutamicum. ..
  40. Maeda T, Wachi M. Corynebacterium glutamicum RNase E/G-type endoribonuclease encoded by NCgl2281 is involved in the 5' maturation of 5S rRNA. Arch Microbiol. 2012;194:65-73 pubmed publisher
    ..glutamicum NCgl2281 endoribonuclease is involved in the 5' maturation of 5S rRNA. This is the first report showing the physiological function of the RNase E/G ortholog in bacteria having one RNase E/G and one RNase J but no RNase Y. ..
  41. Yu Q, Yan Z, He X, Tian F, Jia C, Li C. Corynebacterium defluvii sp. nov., isolated from Sewage. J Microbiol. 2017;55:435-439 pubmed publisher
    ..2%), Corynebacterium deserti GIMN 1.010T (96.8%), Corynebacterium glutamicum ATCC 13032T (96.4%), and other species belonging to this genus (92.3-95.4%)...
  42. Eikmanns B, Rittmann D, Sahm H. Cloning, sequence analysis, expression, and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme. J Bacteriol. 1995;177:774-82 pubmed
    ..The data indicate that ICD from C. glutamicum is structurally similar to ICDs from bacteria of the genera Vibrio, Rhodomicrobium, and Azotobacter but different from all other known procaryotic and eucaryotic ICDs...
  43. Billman Jacobe H. Nucleotide sequence of a recA gene from Corynebacterium glutamicum. DNA Seq. 1994;4:403-4 pubmed
    ..Comparison of the C. glutamicum recA gene sequence to the sequences of other procaryotic recA genes reveals a high degree of identity of both the DNA and inferred amino acid sequences. ..
  44. Cirilli M, Scapin G, Sutherland A, Vederas J, Blanchard J. The three-dimensional structure of the ternary complex of Corynebacterium glutamicum diaminopimelate dehydrogenase-NADPH-L-2-amino-6-methylene-pimelate. Protein Sci. 2000;9:2034-7 pubmed
    ..We have identified a significant interaction between the alpha-L-amino group of the unsaturated inhibitor and the indole ring of Trp144 that may account for the tight binding of this inhibitor. ..
  45. Kim H, Kim Y, Lee M, Lee H. Gene lmrB of Corynebacterium glutamicum confers efflux-mediated resistance to lincomycin. Mol Cells. 2001;12:112-6 pubmed
    ..In addition, the putative protein contained a motif for major facilitators, suggesting a role in efflux-mediated resistance to lincomycin. ..
  46. Yao W, Deng X, Liu M, Zheng P, Sun Z, Zhang Y. Expression and localization of the Corynebacterium glutamicum NCgl1221 protein encoding an L-glutamic acid exporter. Microbiol Res. 2009;164:680-7 pubmed publisher
    ..We herein provide the straightforward and obvious evidence to prove that NCgl1221 is confined to the cytoplasmic membrane. And NCgl1221 is a membrane protein having four transmembrane segments with its C terminus in the cytoplasm. ..
  47. Nakayama Y, Yoshimura K, Iida H. A gain-of-function mutation in gating of Corynebacterium glutamicum NCgl1221 causes constitutive glutamate secretion. Appl Environ Microbiol. 2012;78:5432-4 pubmed publisher
  48. Si M, Zhang L, Chaudhry M, Ding W, Xu Y, Chen C, et al. Corynebacterium glutamicum methionine sulfoxide reductase A uses both mycoredoxin and thioredoxin for regeneration and oxidative stress resistance. Appl Environ Microbiol. 2015;81:2781-96 pubmed publisher
    ..Based on these results, a catalytic model for the reduction of CgMsrA by Mrx1 and Trx is proposed. ..
  49. Matsui K, Sano K, Ohtsubo E. Complete nucleotide and deduced amino acid sequences of the Brevibacterium lactofermentum tryptophan operon. Nucleic Acids Res. 1986;14:10113-4 pubmed
  50. Ruan H, Gerstmeir R, Schnicke S, Eikmanns B. The amrG1 gene is involved in the activation of acetate in Corynebacterium glutamicum. Sci China C Life Sci. 2005;48:97-105 pubmed
    ..In contrast to the gene deletion, overexpression of the amrG1 gene in C. glutamicum 13032 had the adverse regulatory effect. These results indicate that the amrG1 gene encodes a repressor or co-repressor of the pta-ack operon. ..
  51. Hwang G, Cho J. Identification of a suppressor gene for the arginine-auxotrophic argJ mutation in Corynebacterium glutamicum. J Ind Microbiol Biotechnol. 2010;37:1131-6 pubmed publisher
    ..These results indicate that the intracellular supply of N-acetylglutamate is a rate-limiting step during L-ornithine production in C. glutamicum...
  52. Park J, Kim Y, Lee H. Involvement of the NADH oxidase-encoding noxA gene in oxidative stress responses in Corynebacterium glutamicum. Appl Microbiol Biotechnol. 2015;99:1363-74 pubmed publisher
    ..Furthermore, the involvement and roles of the whcA, whcB, and whcE genes in regulating the expression of noxA were demonstrated. ..
  53. Sch fer A, Tauch A, Droste N, P hler A, Kalinowski J. The Corynebacterium glutamicum cglIM gene encoding a 5-cytosine methyltransferase enzyme confers a specific DNA methylation pattern in an McrBC-deficient Escherichia coli strain. Gene. 1997;203:95-101 pubmed
    The cglIM gene of the coryneform soil bacterium Corynebacterium glutamicum ATCC 13032 has been cloned and characterized...
  54. Gourdon P, Baucher M, Lindley N, Guyonvarch A. Cloning of the malic enzyme gene from Corynebacterium glutamicum and role of the enzyme in lactate metabolism. Appl Environ Microbiol. 2000;66:2981-7 pubmed
    ..However, the strain overexpressing malE maintained exponential growth until all lactate had been consumed. This strain accumulated significantly larger amounts of pyruvate in the medium than the other strains...
  55. Park S, Kim H, Yoo S, Oh T, Lee J. Characterization of glk, a gene coding for glucose kinase of Corynebacterium glutamicum. FEMS Microbiol Lett. 2000;188:209-15 pubmed
    ..A chromosomal glk-lacZ fusion was constructed and used to monitor glk expression, and it was found that glk was expressed constitutively under all tested conditions with different carbon sources...
  56. Eikmanns B, Follettie M, Griot M, Sinskey A. The phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum: molecular cloning, nucleotide sequence, and expression. Mol Gen Genet. 1989;218:330-9 pubmed
    ..The sequence predicts a 919 residue protein product (molecular weight of 103 154) which shows 34% similarity with the respective E. coli enzyme...
  57. Peoples O, Liebl W, Bodis M, Maeng P, Follettie M, Archer J, et al. Nucleotide sequence and fine structural analysis of the Corynebacterium glutamicum hom-thrB operon. Mol Microbiol. 1988;2:63-72 pubmed publisher
    ..coli and B. subtilis promoters. Although there are no obvious attenuator-like structures in the 5'-untranslated region, there is a dyad-symmetry element, which may act as an operator...
  58. Yeh P, Sicard A, Sinskey A. Nucleotide sequence of the lysA gene of Corynebacterium glutamicum and possible mechanisms for modulation of its expression. Mol Gen Genet. 1988;212:112-9 pubmed
    ..The upstream sequence requirement apparently associated with the full expression of the lysA gene of C. glutamicum shows some similarity with the Escherichia coli system...
  59. Hatakeyama K, Hohama K, Vert s A, Kobayashi M, Kurusu Y, Yukawa H. Genomic organization of the biotin biosynthetic genes of coryneform bacteria: cloning and sequencing of the bioA-bioD genes from Brevibacterium flavum. DNA Seq. 1993;4:177-84 pubmed
    ..coli and B. sphaericus bioD gene products, respectively. In addition, the genomic organization of the bioA, bioB and bioD genes in B. flavum has been shown to be different from that in E. coli and B. sphaericus...
  60. Oguiza J, Malumbres M, Eriani G, Pisabarro A, Mateos L, Martin F, et al. A gene encoding arginyl-tRNA synthetase is located in the upstream region of the lysA gene in Brevibacterium lactofermentum: regulation of argS-lysA cluster expression by arginine. J Bacteriol. 1993;175:7356-62 pubmed
    ..The transcription of these genes is repressed by lysine and induced by arginine, showing an interesting pattern of biosynthetic interlock between the pathways of both amino acids in corynebacteria...
  61. Scapin G, Reddy S, Blanchard J. Three-dimensional structure of meso-diaminopimelic acid dehydrogenase from Corynebacterium glutamicum. Biochemistry. 1996;35:13540-51 pubmed publisher
    ..Blanchard, J. S., & Sacchettini, J. C. (1995) Biochemistry 34, 3502-3512], the enzyme immediately preceding it in the diaminopimelic acid/lysine biosynthetic pathway...
  62. Jakoby M, Tesch M, Sahm H, Kr mer R, Burkovski A. Isolation of the Corynebacterium glutamicum glnA gene encoding glutamine synthetase I. FEMS Microbiol Lett. 1997;154:81-8 pubmed
    ..Additionally, indications for a second glutamine synthetase, GSII, were found...
  63. Honrubia M, Fern ndez F, Gil J. Identification, characterization, and chromosomal organization of the ftsZ gene from Brevibacterium lactofermentum. Mol Gen Genet. 1998;259:97-104 pubmed
    ..lactofermentum ftsZ gene in E. coli inhibited cell division and led to filamentation. The ftsZ gene of this organism does not complement ftsZ mutations or deletions in E. coli, when cloned on low or high-copy-number vectors...
  64. Chen C, White A, Love J, Murphy J, Ringe D. Methyl groups of thymine bases are important for nucleic acid recognition by DtxR. Biochemistry. 2000;39:10397-407 pubmed
  65. Sakamoto J, Shibata T, Mine T, Miyahara R, Torigoe T, Noguchi S, et al. Cytochrome c oxidase contains an extra charged amino acid cluster in a new type of respiratory chain in the amino-acid-producing Gram-positive bacterium Corynebacterium glutamicum. Microbiology. 2001;147:2865-71 pubmed publisher
    ..These findings suggest that the extra charged cluster may play a role in the interaction of the oxidase with the cytochrome c subunit of the new type of bc complex...
  66. Tauch A, G tker S, P hler A, Kalinowski J, Thierbach G. The alanine racemase gene alr is an alternative to antibiotic resistance genes in cloning systems for industrial Corynebacterium glutamicum strains. J Biotechnol. 2002;99:79-91 pubmed
    The potential of the alanine racemase gene alr from Corynebacterium glutamicum ATCC 13032 to substitute for antibiotic resistance determinants in cloning systems has been investigated...
  67. Krug A, Wendisch V, Bott M. Identification of AcnR, a TetR-type repressor of the aconitase gene acn in Corynebacterium glutamicum. J Biol Chem. 2005;280:585-95 pubmed publisher
    ..glutamicum, and they identify AcnR as the first transcriptional regulator of a tricarboxylic acid cycle gene in the Corynebacterianeae...
  68. Niebisch A, Kabus A, Schultz C, Weil B, Bott M. Corynebacterial protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI protein. J Biol Chem. 2006;281:12300-7 pubmed publisher
    ..glutamicum. Moreover, because this signaling cascade is likely to operate also in mycobacteria, our results suggest that the attenuated pathogenicity of mycobacteria lacking PknG might be caused by a disturbed tricarboxylic acid cycle...
  69. Chaudhry M, Huang Y, Shen X, Poetsch A, Jiang C, Liu S. Genome-wide investigation of aromatic acid transporters in Corynebacterium glutamicum. Microbiology. 2007;153:857-65 pubmed publisher
    ..Thus the functionally identified NCgl2326 belongs to a novel type of benzoate transporters. Attempts to identify the phenotype of a hydK/ncgl2953 mutant failed, so the function of ncgl2953 remains unclear...
  70. Rice E, Bannon G, Glenn K, Jeong S, Sturman E, Rydel T. Characterization and crystal structure of lysine insensitive Corynebacterium glutamicum dihydrodipicolinate synthase (cDHDPS) protein. Arch Biochem Biophys. 2008;480:111-21 pubmed publisher
  71. Batt S, Jabeen T, Mishra A, Veerapen N, Krumbach K, Eggeling L, et al. Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'. J Biol Chem. 2010;285:37741-52 pubmed publisher
  72. Sevvana M, Hasselt K, Grau F, Burkovski A, Muller Y. Similarities in the structure of the transcriptional repressor AmtR in two different space groups suggest a model for the interaction with GlnK. Acta Crystallogr F Struct Biol Commun. 2017;73:146-151 pubmed publisher
  73. Eikmanns B. Identification, sequence analysis, and expression of a Corynebacterium glutamicum gene cluster encoding the three glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and triosephosphate isomerase. J Bacteriol. 1992;174:6076-86 pubmed
    ..On the basis of codon usage analysis of gap, pgk, tpi, and previously sequenced genes from C. glutamicum, a codon preference profile for this organism which differs significantly from those of E. coli and Bacillus subtilis is presented...
  74. Follettie M, Sinskey A. Molecular cloning and nucleotide sequence of the Corynebacterium glutamicum pheA gene. J Bacteriol. 1986;167:695-702 pubmed
    ..The deduced protein product demonstrated sequence homology to the C-terminal two-thirds of the bifunctional E. coli enzyme chorismate mutase-P-prephenate dehydratase...
  75. Heery D, Fitzpatrick R, Dunican L. A sequence from a tryptophan-hyperproducing strain of Corynebacterium glutamicum encoding resistance to 5-methyltryptophan. Biochem Biophys Res Commun. 1994;201:1255-62 pubmed publisher
    ..glutamicum trp operon. The equivalent fragment from the related wild type strain C. glutamicum AS019 was found to contain sequence differences at two positions and had no effect on the sensitivity of E. coli to 5-methyltryptophan...
  76. P tek M, Krumbach K, Eggeling L, Sahm H. Leucine synthesis in Corynebacterium glutamicum: enzyme activities, structure of leuA, and effect of leuA inactivation on lysine synthesis. Appl Environ Microbiol. 1994;60:133-40 pubmed
    ..Fermentations were performed, and a roughly 50% higher lysine yield was obtained when appropriate leucine concentrations limiting for growth of the constructed strains were used...
  77. Hatakeyama K, Kohama K, Vert s A, Kobayashi M, Kurusu Y, Yukawa H. Analysis of the biotin biosynthesis pathway in coryneform bacteria: cloning and sequencing of the bioB gene from Brevibacterium flavum. DNA Seq. 1993;4:87-93 pubmed
    ..B. flavum mutants obtained by in vivo disruption of the bioB gene lost their ability to grow on minimal medium containing dethiobiotin, indicating that the bioB gene product is necessary for the conversion of dethiobiotin to biotin...
  78. Keilhauer C, Eggeling L, Sahm H. Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon. J Bacteriol. 1993;175:5595-603 pubmed
    ..The ilvC transcript of this operon, however, is regulated independently and present in a large excess, which is in accord with the constant IR activities determined...
  79. Scapin G, Cirilli M, Reddy S, Gao Y, Vederas J, Blanchard J. Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase. Biochemistry. 1998;37:3278-85 pubmed publisher
  80. Nolden L, Beckers G, M ckel B, Pfefferle W, Nampoothiri K, Kr mera R, et al. Urease of Corynebacterium glutamicum: organization of corresponding genes and investigation of activity. FEMS Microbiol Lett. 2000;189:305-10 pubmed
    ..As in mycobacteria, in corynebacteria urease activity was highest in a pathogenic species and might also play a role in host-pathogen interaction...
  81. Barreiro C, Gonz lez Lavado E, Mart n J. Organization and transcriptional analysis of a six-gene cluster around the rplK-rplA operon of Corynebacterium glutamicum encoding the ribosomal proteins L11 and L1. Appl Environ Microbiol. 2001;67:2183-90 pubmed publisher
    ..The promoters of the nusG and rplK-rplA genes were subcloned in a novel corynebacterial promoter-probe vector and shown to confer strong expression of the reporter gene...
  82. Nolden L, Farwick M, Kr mer R, Burkovski A. Glutamine synthetases of Corynebacterium glutamicum: transcriptional control and regulation of activity. FEMS Microbiol Lett. 2001;201:91-8 pubmed
    ..glutamicum was isolated. This gene, designated glnA2, forms an operon with glnE, its transcription is not regulated and neither its deletion or overexpression showed any effect. Therefore, the physiological role of glnA2 remains unclear...
  83. Simic P, Sahm H, Eggeling L. L-threonine export: use of peptides to identify a new translocator from Corynebacterium glutamicum. J Bacteriol. 2001;183:5317-24 pubmed
    ..Homologues of ThrE are present in Mycobacterium tuberculosis and Streptomyces coelicolor...
  84. Riedel C, Rittmann D, Dangel P, M ckel B, Petersen S, Sahm H, et al. Characterization of the phosphoenolpyruvate carboxykinase gene from Corynebacterium glutamicum and significance of the enzyme for growth and amino acid production. J Mol Microbiol Biotechnol. 2001;3:573-83 pubmed
    ..glutamicum is counteractive to the production of glutamate and lysine and indicate that the enzyme is an important target in the development of strains producing amino acids derived from citric acid cycle intermediates...
  85. Kennerknecht N, Sahm H, Yen M, P tek M, Saier Jr M, Eggeling L. Export of L-isoleucine from Corynebacterium glutamicum: a two-gene-encoded member of a new translocator family. J Bacteriol. 2002;184:3947-56 pubmed
    ..Comparisons of the BrnF and BrnE phylogenetic trees show that gene duplication events in the early bacterial lineage gave rise to multiple paralogues that have been retained in alpha-proteobacteria but not in other prokaryotes analyzed...
  86. Simic P, Willuhn J, Sahm H, Eggeling L. Identification of glyA (encoding serine hydroxymethyltransferase) and its use together with the exporter ThrE to increase L-threonine accumulation by Corynebacterium glutamicum. Appl Environ Microbiol. 2002;68:3321-7 pubmed
    ..This shows that the potential for amino acid formation can be considerably improved by reducing its intracellular degradation and increasing its export...
  87. Kim H, Kim T, Kim Y, Lee H. Identification and characterization of glxR, a gene involved in regulation of glyoxylate bypass in Corynebacterium glutamicum. J Bacteriol. 2004;186:3453-60 pubmed publisher
    ..These data suggest that GlxR may form dimers which bind to the aceB promoter region in the presence of cAMP and repress the glyoxylate bypass genes...
  88. Deniziak M, Sauter C, Becker H, Paulus C, Gieg R, Kern D. Deinococcus glutaminyl-tRNA synthetase is a chimer between proteins from an ancient and the modern pathways of aminoacyl-tRNA formation. Nucleic Acids Res. 2007;35:1421-31 pubmed publisher
    ..However, the presence of Yqey in free state in organisms lacking GlnRS, suggests that this domain may exert additional cellular functions...
  89. Kronemeyer W, Peekhaus N, Kramer R, Sahm H, Eggeling L. Structure of the gluABCD cluster encoding the glutamate uptake system of Corynebacterium glutamicum. J Bacteriol. 1995;177:1152-8 pubmed
    ..With this strain, the glutamate excretion rate was unaffected (18 nmol/min/mg), showing that no component of gluABCD is involved in export but rather that a specific machinery functions for the latter purpose...
  90. Tauch A, Krieft S, Puhler A, Kalinowski J. The tetAB genes of the Corynebacterium striatum R-plasmid pTP10 encode an ABC transporter and confer tetracycline, oxytetracycline and oxacillin resistance in Corynebacterium glutamicum. FEMS Microbiol Lett. 1999;173:203-9 pubmed
    ..the 50-kb R-plasmid pTP10 from the clinical isolate Corynebacterium striatum M82B was analyzed in Corynebacterium glutamicum ATCC 13032 and confined to a 4.4-kb SphI-Sa/I DNA fragment...
  91. Beckers G, Bendt A, Kramer R, Burkovski A. Molecular identification of the urea uptake system and transcriptional analysis of urea transporter- and urease-encoding genes in Corynebacterium glutamicum. J Bacteriol. 2004;186:7645-52 pubmed
  92. Harms A, Treuner Lange A, Schumacher D, S gaard Andersen L. Tracking of chromosome and replisome dynamics in Myxococcus xanthus reveals a novel chromosome arrangement. PLoS Genet. 2013;9:e1003802 pubmed publisher
    ..We conclude that M. xanthus chromosome arrangement and dynamics combine features from previously described systems with new features leading to a novel spatiotemporal arrangement pattern...