Yersinia enterocolitica subsp. enterocolitica 8081


Alias: Yersinia enterocolitica subsp. enterocolitica str. 8081, Yersinia enterocolitica subsp. enterocolitica strain 8081

Top Publications

  1. Guilvout I, Mercereau Puijalon O, Bonnefoy S, Pugsley A, Carniel E. High-molecular-weight protein 2 of Yersinia enterocolitica is homologous to AngR of Vibrio anguillarum and belongs to a family of proteins involved in nonribosomal peptide synthesis. J Bacteriol. 1993;175:5488-504 pubmed
    ..This finding suggests that HMWP2 may participate in the nonribosomal synthesis of small biologically active peptides...
  2. Zacharczuk K, Gierczyński R. [C-terminal region of MyfA, the major subunit of Yersinia enterocolitica Myf fimbriae, is conserved among pathogenic strains]. Med Dosw Mikrobiol. 2010;62:331-6 pubmed
    ..enterocolitica indicate that fimbriae MyF could play important role in pathogenesis, even before the divergence of European and American lineages. ..
  3. Nuss A, Schuster F, Roselius L, Klein J, Bücker R, Herbst K, et al. A Precise Temperature-Responsive Bistable Switch Controlling Yersinia Virulence. PLoS Pathog. 2016;12:e1006091 pubmed publisher
  4. Dowd G, Bhalla M, Kean B, Thomas R, Ireton K. Role of Host Type IA Phosphoinositide 3-Kinase Pathway Components in Invasin-Mediated Internalization of Yersinia enterocolitica. Infect Immun. 2016;84:1826-1841 pubmed publisher
    ..enterocolitica and L. monocytogenes. ..
  5. Zhang L, Toivanen P, Skurnik M. The gene cluster directing O-antigen biosynthesis in Yersinia enterocolitica serotype 0:8: identification of the genes for mannose and galactose biosynthesis and the gene for the O-antigen polymerase. Microbiology. 1996;142 ( Pt 2):277-88 pubmed
    ..Also in other Yersinia spp., the locus downstream of the hemH gene is occupied by gene clusters associated with LPS biosynthesis. ..
  6. Walker K, Griggs L, Obrist M, Bode A, Summers R, Miller V. The YsrS Paralog DygS Has the Capacity To Activate Expression of the Yersinia enterocolitica Ysa Type III Secretion System. J Bacteriol. 2016;198:1725-1734 pubmed publisher
    ..The significance of this work lies in finding that two HKs regulate this T3SS, highlighting its importance. ..
  7. Scharnert J, Greune L, Zeuschner D, Lubos M, Alexander Schmidt M, Rüter C. Autonomous translocation and intracellular trafficking of the cell-penetrating and immune-suppressive effector protein YopM. Cell Mol Life Sci. 2013;70:4809-23 pubmed publisher
    ..Surprisingly, even when endocytosis is blocked, YopM was found to be associated with endosomes. This suggests an intracellular endosome-associated transport of YopM. ..
  8. Zacharczuk K. [Investigation of molecular virulence factors of Yersinia enterocolitica 1B/08 human clinical isolates collected in Poland in 2009]. Med Dosw Mikrobiol. 2013;65:233-43 pubmed
    ..Presence of the genes encoding yersiniabactin (irp1+, irp2+, fuyA+), chromosomal secretion system Ysa (chiY+, ysrS+) and Yst1 (yst1+) may argue for the extended pathogenic potential of the Y. enterocolitica bioserotype 1B/O8 in Poland. ..
  9. Compton E, Page K, Findlay H, Haertlein M, Moulin M, Zachariae U, et al. Conserved structure and domain organization among bacterial Slc26 transporters. Biochem J. 2014;463:297-307 pubmed publisher
    ..We use the SANS-generated envelopes to assess a homology model of the TM core. ..

More Information


  1. O Gaora P, Maskel D, Coleman D, Cafferkey M, Dougan G. Cloning and characterisation of the serC and aroA genes of Yersinia enterocolitica, and construction of an aroA mutant. Gene. 1989;84:23-30 pubmed
    ..The cloned Y. enterocolitica aroA gene was inactivated in vitro and reintroduced into the parental Y. enterocolitica 8081 strain using the suicide vector pJM703.1. Stable aroA insertion mutants of Y. enterocolitica were isolated. ..
  2. Raczkowska A, Brzóstkowska M, Brzostek K. Regulation of Yersinia enterocolitica mal genes by MalT and Mlc proteins. Pol J Microbiol. 2008;57:19-26 pubmed
    ..Thus, the data presented in this study suggest that the level of mal gene expression in Y. enterocolitica may be regulated by two proteins: MalT, the activator of mal transcription and Mlc, the repressor of malT expression. ..
  3. Abbott D, Gilbert H, Boraston A. The active site of oligogalacturonate lyase provides unique insights into cytoplasmic oligogalacturonate beta-elimination. J Biol Chem. 2010;285:39029-38 pubmed publisher
    ..In addition, we present a hypothesis for an emerging relationship observed between the cellular distribution of pectate lyase folding and the distinct metal coordination chemistries of pectate lyases. ..
  4. Boraston A, Abbott D. Structure of a pectin methylesterase from Yersinia enterocolitica. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:129-33 pubmed publisher
  5. Kerbarh O, Chirgadze D, Blundell T, Abell C. Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate. J Mol Biol. 2006;357:524-34 pubmed
    ..Knowledge of the structure of Irp9 will guide the search for potent inhibitors of salicylate formation, and hence of bacterial iron uptake, which is directly related to the virulence of Yersinia. ..
  6. Flores Kim J, Darwin A. Interactions between the Cytoplasmic Domains of PspB and PspC Silence the Yersinia enterocolitica Phage Shock Protein Response. J Bacteriol. 2016;198:3367-3378 pubmed
    ..This study provides an important advance by uncovering a new protein interaction domain within this membrane protein complex that is essential to silencing the Psp response in the absence of an inducing stimulus. ..
  7. Bancerz Kisiel A, Lipczyńska K, Szczerba Turek A, Gospodarek E, Platt Samoraj A, Szweda W. The use of the HRM method for identifying possible mutations in the ymoA gene region and evaluating their influence on the enterotoxic properties of Y. enterocolitica strains. BMC Vet Res. 2014;10:207 pubmed publisher
    ..No correlations were observed between enterotoxic properties and the presence of mutations in the ymoA gene region of Y. enterocolitica strains isolated from both humans and pigs. ..
  8. Höfling S, Scharnert J, Cromme C, Bertrand J, Pap T, Schmidt M, et al. Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2. Virulence. 2014;5:761-71 pubmed publisher
    ..Here, we could exclude that interaction with RSK1 and PRK2 is essential for the anti-inflammatory effects of rYopM. ..
  9. Meneely K, Lamb A. Two structures of a thiazolinyl imine reductase from Yersinia enterocolitica provide insight into catalysis and binding to the nonribosomal peptide synthetase module of HMWP1. Biochemistry. 2012;51:9002-13 pubmed publisher
  10. Raczkowska A, Trzos J, Lewandowska O, Nieckarz M, Brzostek K. Expression of the AcrAB Components of the AcrAB-TolC Multidrug Efflux Pump of Yersinia enterocolitica Is Subject to Dual Regulation by OmpR. PLoS ONE. 2015;10:e0124248 pubmed publisher
    ..enterocolitica O:9 to different chemical stressors, thus conferring an advantage in particular ecological niches. ..
  11. Chen Y, Duan R, Li X, Li K, Liang J, Liu C, et al. Homology analysis and cross-immunogenicity of OmpA from pathogenic Yersinia enterocolitica, Yersinia pseudotuberculosis and Yersinia pestis. Mol Immunol. 2015;68:290-9 pubmed publisher
    ..Immunological analysis showed the immunogenicity of each OmpA and cross-immunogenicity of OmpA for pathogenic Yersinia where OmpA may be a vaccine candidate for Y. pestis and other pathogenic Yersinia. ..
  12. Kim Y, Chhor G, Tsai C, Fox G, Chen C, Winans N, et al. X-ray crystal structures of the pheromone-binding domains of two quorum-hindered transcription factors, YenR of Yersinia enterocolitica and CepR2 of Burkholderia cenocepacia. Proteins. 2017;85:1831-1844 pubmed publisher
  13. McFeeters R, Altieri A, Cherry S, Tropea J, Waugh D, Byrd R. The high-precision solution structure of Yersinia modulating protein YmoA provides insight into interaction with H-NS. Biochemistry. 2007;46:13975-82 pubmed
    ..YmoA is also found to be structurally similar to the histone-like nucleoid structuring protein H-NS, indicating that YmoA may intercalate into higher-order H-NS suprastructuring by substituting for an H-NS dimer. ..
  14. Shouldice S, McRee D, Dougan D, Tari L, Schryvers A. Novel anion-independent iron coordination by members of a third class of bacterial periplasmic ferric ion-binding proteins. J Biol Chem. 2005;280:5820-7 pubmed
    ..The iron-free SfuA structure contains a bound citrate anion in the iron-binding cleft that tethers the N- and C-terminal domains of the apo protein and stabilizes the partially open structure. ..
  15. Yamaguchi S, Gueguen E, Horstman N, Darwin A. Membrane association of PspA depends on activation of the phage-shock-protein response in Yersinia enterocolitica. Mol Microbiol. 2010;78:429-43 pubmed
    ..Once this switch is activated PspA concentration increases, which might then allow it to directly contact the membrane for its physiological function...
  16. Zhou T, Radaev S, Rosen B, Gatti D. Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation. J Biol Chem. 2001;276:30414-22 pubmed publisher
    ..Based on the observed conformational changes, it is proposed that ArsA functions as a reciprocating engine that hydrolyzes 2 mol of ATP per each cycle of ion translocation across the membrane...
  17. Xue L, Guo W, Yuan Y, Anino E, Nyamdari B, Wilson M, et al. Constitutively elevated salicylic acid levels alter photosynthesis and oxidative state but not growth in transgenic populus. Plant Cell. 2013;25:2714-30 pubmed publisher
  18. Kakoschke T, Kakoschke S, Magistro G, Schubert S, Borath M, Heesemann J, et al. The RNA chaperone Hfq impacts growth, metabolism and production of virulence factors in Yersinia enterocolitica. PLoS ONE. 2014;9:e86113 pubmed publisher
    ..Overall, Hfq has a profound effect on metabolism, resistance to stress and modulates the production of two virulence factors in Y. enterocolitica, namely urease and yersiniabactin...
  19. Forsberg A, Wolf Watz H. Genetic analysis of the yopE region of Yersinia spp.: identification of a novel conserved locus, yerA, regulating yopE expression. J Bacteriol. 1990;172:1547-55 pubmed
    ..The expression level could be restored by transcomplementation. This new locus was designated yerA, for yopE-regulating gene A. The yerA mutant was avirulent when mice were challenged by oral infection...
  20. Biedzka Sarek M, Jarva H, Hyyti inen H, Meri S, Skurnik M. Characterization of complement factor H binding to Yersinia enterocolitica serotype O:3. Infect Immun. 2008;76:4100-9 pubmed publisher
    ..We thus conclude that Y. enterocolitica, via YadA and Ail, recruits functionally active FH to its surface. FH binding appears to be an important mechanism of the complement resistance of this pathogen...
  21. Skurnik M, Wolf Watz H. Analysis of the yopA gene encoding the Yop1 virulence determinants of Yersinia spp. Mol Microbiol. 1989;3:517-29 pubmed
    ..pestis. Thus, the inability of Y.pestis to express the Yop1 protein is due to a single base pair deletion in the coding region of the yopA gene of Y.pestis...
  22. Rakin A, Urbitsch P, Heesemann J. Evidence for two evolutionary lineages of highly pathogenic Yersinia species. J Bacteriol. 1995;177:2292-8 pubmed
    ..2 and 59.8 mol%), leads to the assumption that these two genes may represent part of an unstable pathogenicity island that has been acquired by pesticin-sensitive bacteria as a result of a horizontal transfer...
  23. Kapatral V, Olson J, Pepe J, Miller V, Minnich S. Temperature-dependent regulation of Yersinia enterocolitica Class III flagellar genes. Mol Microbiol. 1996;19:1061-71 pubmed
    ..Unlike S. typhimurium flgM mutants, Y. enterocolitica flgM mutants are fully virulent...
  24. Zhou T, Radaev S, Rosen B, Gatti D. Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump. EMBO J. 2000;19:4838-45 pubmed publisher
    ..The relative positions of the NBS and the inferred mechanism of allosteric activation of ArsA provide a useful model for the interaction of the catalytic domains in other transport ATPases...
  25. Birtalan S, Ghosh P. Structure of the Yersinia type III secretory system chaperone SycE. Nat Struct Biol. 2001;8:974-8 pubmed publisher
    ..The structure provides the first structural insights into possible modes of action of SycE and type III chaperones in general...
  26. Birtalan S, Phillips R, Ghosh P. Three-dimensional secretion signals in chaperone-effector complexes of bacterial pathogens. Mol Cell. 2002;9:971-80 pubmed
  27. Schneider S, Sharp K, Barker P, Paoli M. An induced fit conformational change underlies the binding mechanism of the heme transport proteobacteria-protein HemS. J Biol Chem. 2006;281:32606-10 pubmed publisher
    ..This is the first report in which both liganded and unliganded forms of a heme transport protein are described, thus providing penetrating insights into its mechanism of heme binding and release...
  28. Thinwa J, Segovia J, Bose S, Dube P. Integrin-mediated first signal for inflammasome activation in intestinal epithelial cells. J Immunol. 2014;193:1373-82 pubmed publisher
    ..These data suggest integrins function as pathogen recognition receptors on IECs to rapidly induce inflammasome-derived IL-18-mediated responses...
  29. Axler DiPerte G, Miller V, Darwin A. YtxR, a conserved LysR-like regulator that induces expression of genes encoding a putative ADP-ribosyltransferase toxin homologue in Yersinia enterocolitica. J Bacteriol. 2006;188:8033-43 pubmed publisher
    ..These observations suggest that YtxR may play a conserved role involving regulation of other genes besides ytxAB...
  30. Abbott D, Hrynuik S, Boraston A. Identification and characterization of a novel periplasmic polygalacturonic acid binding protein from Yersinia enterolitica. J Mol Biol. 2007;367:1023-33 pubmed publisher
    ..The results suggest the possibility of a unique role for YeCBM32 in polygalacturonic acid transport...
  31. Abbott D, Boraston A. The structural basis for exopolygalacturonase activity in a family 28 glycoside hydrolase. J Mol Biol. 2007;368:1215-22 pubmed publisher
    ..In addition, YeGH28 possesses a fused FN3 domain with unknown function, the first such structure described in pectin active enzymes...
  32. Zheng Y, Lilo S, Mena P, Bliska J. YopJ-induced caspase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, dispensable for innate host defense. PLoS ONE. 2012;7:e36019 pubmed publisher
    ..These data suggest that YopJ-induced caspase-1 activation in Yersinia-infected macrophages is a downstream consequence of necrotic cell death and is dispensable for innate host resistance to a strain with enhanced cytotoxicity...
  33. Rein s M, Llobet E, Llompart C, Moranta D, P rez Guti rrez C, Bengoechea J. Molecular basis of Yersinia enterocolitica temperature-dependent resistance to antimicrobial peptides. J Bacteriol. 2012;194:3173-88 pubmed publisher
    ..However, rovA expression reached wild-type levels in the phoPQ pmrAB mutant background, hence indicating the existence of an unknown regulatory network controlling rovA expression in this background...
  34. Abbott D, Boraston A. Specific recognition of saturated and 4,5-unsaturated hexuronate sugars by a periplasmic binding protein involved in pectin catabolism. J Mol Biol. 2007;369:759-70 pubmed
    ..The ligand binding profiles of the TogMNAB transporter complex nicely complement pectate lyase-mediated pectin degradation, which is a significant component of pectin depolymerization reactions...
  35. Pinta E, Li Z, Batzilla J, Pajunen M, Kasanen T, Rabsztyn K, et al. Identification of three oligo-/polysaccharide-specific ligases in Yersinia enterocolitica. Mol Microbiol. 2012;83:125-36 pubmed publisher
    ..This is the first report on the presence of three different oligo-/polysaccharide-specific ligases in a single bacterium...
  36. Abbott D, Boraston A. A family 2 pectate lyase displays a rare fold and transition metal-assisted beta-elimination. J Biol Chem. 2007;282:35328-36 pubmed publisher
  37. Gueguen E, Savitzky D, Darwin A. Analysis of the Yersinia enterocolitica PspBC proteins defines functional domains, essential amino acids and new roles within the phage-shock-protein response. Mol Microbiol. 2009;74:619-33 pubmed publisher
    ..These data provide compelling support for the proposal that these two functions are independent...
  38. Biedzka Sarek M, Salmenlinna S, Gruber M, Lupas A, Meri S, Skurnik M. Functional mapping of YadA- and Ail-mediated binding of human factor H to Yersinia enterocolitica serotype O:3. Infect Immun. 2008;76:5016-27 pubmed publisher
    ..On the other hand, the complement-sensitive Ail mutants were not affected in FH binding. Our results also suggested that Ail- and YadA-mediated CR does not depend solely on FH binding...