Vibrio cholerae O1 biovar El Tor str. N16961

Summary

Alias: Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961

Top Publications

  1. pmc Cloning and nucleotide sequence of the Vibrio cholerae hemagglutinin/protease (HA/protease) gene and construction of an HA/protease-negative strain
    C C Häse
    Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212
    J Bacteriol 173:3311-7. 1991
  2. pmc Comparison of the Vibrio cholerae hemagglutinin/protease and the Pseudomonas aeruginosa elastase
    C C Häse
    Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri Columbia 65212
    Infect Immun 58:4011-5. 1990
  3. pmc Vibrio cholerae Hcp, a secreted protein coregulated with HlyA
    S G Williams
    Department of Microbiology and Immunology, University of Adelaide, Australia
    Infect Immun 64:283-9. 1996
  4. pmc Cloning and characterization of the gene encoding the OmpU outer membrane protein of Vibrio cholerae
    V Sperandio
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 64:5406-9. 1996
  5. pmc Role of rpoS in stress survival and virulence of Vibrio cholerae
    F H Yildiz
    Department of Microbiology and Immunology, Stanford University Medical School, California 94305 5428, USA
    J Bacteriol 180:773-84. 1998
  6. pmc Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage
    W Lin
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:1071-6. 1999
  7. pmc Genetic and transcriptional analyses of the Vibrio cholerae mannose-sensitive hemagglutinin type 4 pilus gene locus
    J W Marsh
    Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Bacteriol 181:1110-7. 1999
  8. pmc Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio cholerae
    K J Fullner
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 67:1393-404. 1999
  9. ncbi Molecular cloning and transcriptional regulation of ompT, a ToxR-repressed gene in Vibrio cholerae
    C C Li
    Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, School of Medicine, Baltimore, MD 21201, USA
    Mol Microbiol 35:189-203. 2000
  10. ncbi Filamentous phage integration requires the host recombinases XerC and XerD
    Kathryn E Huber
    Division of Geographic Medicine Infectious Diseases, New England Medical Center and Department of Microbiology, Tufts University School of Medicine and Howard Hughes Medical Institute, 750 Washington Street, Boston, Massachusetts 02111, USA
    Nature 417:656-9. 2002

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Scientific Experts

Detail Information

Publications125 found, 100 shown here

  1. pmc Cloning and nucleotide sequence of the Vibrio cholerae hemagglutinin/protease (HA/protease) gene and construction of an HA/protease-negative strain
    C C Häse
    Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212
    J Bacteriol 173:3311-7. 1991
    ..cholerae by recombination to construct the HA/protease-negative strain HAP-1. The cloned fragment containing the hap gene was then shown to complement the mutant strain...
  2. pmc Comparison of the Vibrio cholerae hemagglutinin/protease and the Pseudomonas aeruginosa elastase
    C C Häse
    Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri Columbia 65212
    Infect Immun 58:4011-5. 1990
    ..1 micrograms and necrosis at a higher dose (i.e., 5 micrograms). We conclude that the V. cholerae HA/protease and the P. aeruginosa elastase are structurally, functionally, and immunologically related...
  3. pmc Vibrio cholerae Hcp, a secreted protein coregulated with HlyA
    S G Williams
    Department of Microbiology and Immunology, University of Adelaide, Australia
    Infect Immun 64:283-9. 1996
    ..We predict that an intermediate regulator may be involved in the activation of hcp by HlyU. This raises the possibility that HlyU is part of a regulatory cascade...
  4. pmc Cloning and characterization of the gene encoding the OmpU outer membrane protein of Vibrio cholerae
    V Sperandio
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 64:5406-9. 1996
    ..The ompU gene is predicted to encode a 36,646-molecular-weight protein which is present in both cholera toxin-positive and -negative V. cholerae O1 and O139 strains...
  5. pmc Role of rpoS in stress survival and virulence of Vibrio cholerae
    F H Yildiz
    Department of Microbiology and Immunology, Stanford University Medical School, California 94305 5428, USA
    J Bacteriol 180:773-84. 1998
    ..In addition, the rpoS mutation led to reduced production or secretion of hemagglutinin/protease. However, rpoS is not critical for in vivo survival, as determined by an infant mouse intestinal competition assay...
  6. pmc Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage
    W Lin
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:1071-6. 1999
    ..Furthermore, the RTX toxin of V. cholerae may be associated with residual adverse properties displayed by certain live, attenuated cholera vaccines...
  7. pmc Genetic and transcriptional analyses of the Vibrio cholerae mannose-sensitive hemagglutinin type 4 pilus gene locus
    J W Marsh
    Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Bacteriol 181:1110-7. 1999
    ..The finding that the MSHA locus lies between these two E. coli homologs and that it is flanked by a 7-bp direct repeat suggests that the MSHA locus may have been acquired as a mobile genetic element...
  8. pmc Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio cholerae
    K J Fullner
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 67:1393-404. 1999
    ..Taken together, these data demonstrate the effectiveness of the V. cholerae genome project for rapid identification and characterization of potential virulence factors...
  9. ncbi Molecular cloning and transcriptional regulation of ompT, a ToxR-repressed gene in Vibrio cholerae
    C C Li
    Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, School of Medicine, Baltimore, MD 21201, USA
    Mol Microbiol 35:189-203. 2000
    ..The regions protected by ToxR on each of these promoters are all A/T rich and large in size, although they are positioned differently relative to each transcriptional start site...
  10. ncbi Filamentous phage integration requires the host recombinases XerC and XerD
    Kathryn E Huber
    Division of Geographic Medicine Infectious Diseases, New England Medical Center and Department of Microbiology, Tufts University School of Medicine and Howard Hughes Medical Institute, 750 Washington Street, Boston, Massachusetts 02111, USA
    Nature 417:656-9. 2002
    ..cholerae chromosomes. Examination of sequences of the integration sites of other filamentous phages indicates that the XerCD recombinases also mediate the integration of these phage genomes at dif-like sites in various bacterial species...
  11. ncbi Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae
    Melissa B Miller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell 110:303-14. 2002
    ..cholerae. This quorum sensing apparatus is unusually complex, as it is composed of at least three parallel signaling channels. We show that in V. cholerae these communication systems converge to control virulence...
  12. pmc Identification of a domain within the multifunctional Vibrio cholerae RTX toxin that covalently cross-links actin
    Kerri Lynn Sheahan
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 101:9798-803. 2004
    ..The presence of this second ACD linked to an Rhs-like element suggests that V. cholerae acquired the domain by horizontal gene transfer and the ACD was inserted into the RTX toxin by gene duplication through the evolution of V. cholerae...
  13. ncbi Hfq is essential for Vibrio cholerae virulence and downregulates sigma expression
    Yanpeng Ding
    Howard Hughes Medical Institute and Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Mol Microbiol 53:345-54. 2004
    ..However, increased sigma(E) does not appear to account for this strain's reduced virulence. It is likely that sRNAs, in conjunction with Hfq, are critical regulators of V. cholerae pathogenicity...
  14. ncbi The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae
    Derrick H Lenz
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell 118:69-82. 2004
    ..We propose that Hfq, together with these sRNAs, creates an ultrasensitive regulatory switch that controls the critical transition into the high cell density, quorum-sensing mode...
  15. ncbi Antimicrobial peptides activate the Vibrio cholerae sigmaE regulon through an OmpU-dependent signalling pathway
    Jyoti Mathur
    Program in Immunology, Tufts University and Howard Hughes Medical Institute, 136 Harrison Avenue, Boston, MA 02111, USA
    Mol Microbiol 63:848-58. 2007
    ..We propose that AP-induced membrane perturbations change the conformation of OmpU to trigger a DegS-dependent sigma(E)-activating cascade. Thus, OmpU appears to act as a sensor component in a signal transduction pathway...
  16. pmc MARTX, multifunctional autoprocessing repeats-in-toxin toxins
    Karla J Fullner Satchell
    Department of Microbiology Immunology, Northwestern University Medical School, Tarry 3 713, 303 E Chicago Ave, Chicago, IL 60611, USA
    Infect Immun 75:5079-84. 2007
  17. doi A ToxR-dependent role for the putative phosphoporin VCA1008 in bile salt resistance in Vibrio cholerae El Tor N16961
    Carolina Lage Goulart
    Unidade Multidisciplinar de Genômica, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Microbiology 156:3011-20. 2010
    ..cholerae...
  18. pmc Glucose-specific enzyme IIA has unique binding partners in the vibrio cholerae biofilm
    Bradley S Pickering
    Division of Infectious Diseases, Boston Children s Hospital, Boston, Massachusetts, USA
    MBio 3:e00228-12. 2012
    ..We hypothesize that EIIA(Glc) serves as a hub for multiprotein complexes and furthermore that these complexes may provide a mechanism for competitive and cooperative interactions between binding partners...
  19. pmc Cloning and genetic analysis of the Vibrio cholerae aminopeptidase gene
    C Toma
    Department of Bacteriology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Infect Immun 64:4495-500. 1996
    ..These results suggested that the protein was a leucine aminopeptidase. The PCR analysis of lap gene distribution showed that it was widely distributed among the V. cholerae strains. It was not present in the other species examined...
  20. pmc NspS, a predicted polyamine sensor, mediates activation of Vibrio cholerae biofilm formation by norspermidine
    Ece Karatan
    Tufts New England Medical Center, Department of Geographic Medicine and Infectious Diseases, 750 Washington St, Box 041, Boston, MA 02111, USA
    J Bacteriol 187:7434-43. 2005
    ..We suggest that norspermidine serves as an intercellular signaling molecule that mediates the attachment of V. cholerae to the biotic surfaces presented by one or more of these organisms...
  21. pmc Haemophilus influenzae Rd lacks a stringently conserved fatty acid biosynthetic enzyme and thermal control of membrane lipid composition
    Haihong Wang
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    J Bacteriol 185:4930-7. 2003
    ..We also demonstrate that the fabB gene of Vibrio cholerae El Tor N16961 does not contain a frameshift mutation as was previously reported.
  22. ncbi Primary structure of cholera toxin B-subunit
    C Y Lai
    Biochem Biophys Res Commun 74:215-22. 1977
  23. pmc Positive transcriptional regulation of an iron-regulated virulence gene in Vibrio cholerae
    M B Goldberg
    Infectious Disease Unit, Massachusetts General Hospital, Boston 02114
    Proc Natl Acad Sci U S A 88:1125-9. 1991
    ..It seems likely that the high induction ratio of irgA expression under low- and high-iron conditions (850-fold) relates to the fact that its cognate positive transcriptional activator (irgB) is itself negatively regulated by iron...
  24. pmc Two-step processing for activation of the cytolysin/hemolysin of Vibrio cholerae O1 biotype El Tor: nucleotide sequence of the structural gene (hlyA) and characterization of the processed products
    K Yamamoto
    Department of Bacteriology and Serology, Osaka University, Japan
    Infect Immun 58:4106-16. 1990
    ....
  25. pmc Transcriptional regulation by iron of a Vibrio cholerae virulence gene and homology of the gene to the Escherichia coli fur system
    M B Goldberg
    Infectious Disease Unit, Massachusetts General Hospital, Boston 02114
    J Bacteriol 172:6863-70. 1990
    ..coli. Unlike iron-regulated genes in E. coli, however, transcription of irgA requires an additional 900 bp of upstream DNA that contains an open reading frame in inverse orientation to irgA...
  26. pmc Nucleotide sequence of the gene, ompW, encoding a 22kDa immunogenic outer membrane protein of Vibrio cholerae
    M B Jalajakumari
    Department of Microbiology and Immunology, University of Adelaide, Australia
    Nucleic Acids Res 18:2180. 1990
  27. pmc Broad-host-range vectors for delivery of TnphoA: use in genetic analysis of secreted virulence determinants of Vibrio cholerae
    R K Taylor
    Harvard Medical School, Department of Microbiology and Molecular Genetics, Boston, Massachusetts 02115
    J Bacteriol 171:1870-8. 1989
    ..cholerae in vivo. The expression of the hybrid proteins as determined by measuring alkaline phosphatase activity also allowed the convenient study of virulence gene expression...
  28. ncbi The deduced Vibrio cholerae RecA amino-acid sequence
    R L Margraf
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706 1569
    Gene 152:135-6. 1995
    ..The amino acid (aa) sequence of the protein product is very similar to other known RecA aa sequences. However, this sequence does not agree with a previously reported Vc RecA aa sequence [Ghosh et al., Nucleic Acids Res. 20 (1992) 372]...
  29. ncbi Cloning and sequencing of a K+ transport gene (trk A) from the marine bacterium Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Biochim Biophys Acta 1219:701-5. 1994
    ..This gene has 71% homology to trkA gene at the DNA level from E. coli and the deduced amino acid sequence is 79% identical with E. coli TrkA, implying that V. alginolyticus has a trkA-like gene as a component of K+ transport systems...
  30. ncbi Genetic characterization of mannose-sensitive hemagglutinin (MSHA)-negative mutants of Vibrio cholerae derived by Tn5 mutagenesis
    C C Häse
    Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212
    Gene 150:17-25. 1994
    ..cholerae strains. The phenotypes of these mutants showed that this DNA region is involved in MSHA production, but is not required for general extracellular protein secretion...
  31. ncbi A protein required for secretion of cholera toxin through the outer membrane of Vibrio cholerae
    M Sandkvist
    Department of Microbiology, Michigan State University, East Lansing 48824
    Gene 123:81-6. 1993
    ..Sequence similarities in its potential ATP-binding site suggest that the protein may act as an energy provider or signal transducer in the process of extracellular secretion...
  32. pmc Nucleotide sequence encoding the mannose-fucose-resistant hemagglutinin of Vibrio cholerae O1 and construction of a mutant
    V L Franzon
    Department of Microbiology and Immunology, University of Adelaide, Australia
    Infect Immun 61:3032-7. 1993
    ..This defect also leads to a > 100-fold increase in the 50% lethal dose. These data suggest that the MFRHA is an important colonization factor in the infant mouse model...
  33. ncbi A putative pathway for biosynthesis of the O-antigen component, 3-deoxy-L-glycero-tetronic acid, based on the sequence of the Vibrio cholerae O1 rfb region
    R Morona
    Department of Microbiology and Immunology, University of Adelaide, Australia
    Gene 166:19-31. 1995
    ..A biosynthetic pathway for the Vc O-antigen component 3-deoxy-L-glycero-tetronic acid, based on the enzymatic functions predicted for the RfbK, RfbL, RfbM, RfbN and RfbO proteins, is presented...
  34. pmc Cloning of a Vibrio cholerae vibriobactin gene cluster: identification of genes required for early steps in siderophore biosynthesis
    E E Wyckoff
    Department of Microbiology, University of Texas, Austin 78712 1095, USA
    J Bacteriol 179:7055-62. 1997
    ..cholerae strain with a chromosomal mutation in vibA was constructed by marker exchange. This strain was unable to produce vibriobactin or DHBA, confirming that in V. cholerae VibA catalyzes an early step in vibriobactin biosynthesis...
  35. pmc Differential regulation of multiple flagellins in Vibrio cholerae
    K E Klose
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 180:303-16. 1998
    ..These results reveal that the V. cholerae flagellum is a complex structure with multiple flagellin subunits including FlaA, which is essential for flagellar synthesis and is differentially regulated from the other flagellins...
  36. ncbi Isolation and characterization of a putative multidrug resistance pump from Vibrio cholerae
    J A Colmer
    Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock 79430, USA
    Mol Microbiol 27:63-72. 1998
    ..cholerae. In addition, the presence of both structural and functional similarities between VceAB and EmrAB suggests that VceAB is a homologue of EmrAB...
  37. pmc Nucleotide sequence and spatiotemporal expression of the Vibrio cholerae vieSAB genes during infection
    S H Lee
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Bacteriol 180:2298-305. 1998
    ..We found that vieB transcription is induced shortly after infection of the proximal and mid-small intestine...
  38. pmc CTXphi immunity: application in the development of cholera vaccines
    H H Kimsey
    Division of Geographic Medicine and Infectious Diseases, Tupper Research Institute, Tufts New England Medical Center 041, 750 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 95:7035-9. 1998
    ..cholerae vaccine strains effectively protected these vaccines from CTXphi infection. Introduction of rstR into V. cholerae vaccine strains should enhance their biosafety...
  39. ncbi The genes responsible for O-antigen synthesis of vibrio cholerae O139 are closely related to those of vibrio cholerae O22
    S Yamasaki
    Research Institute, International Medical Center of Japan, Toyama, Tokyo, Japan
    Gene 237:321-32. 1999
    ..cholerae. These data suggest that the gene clusters responsible for O139 O-antigen biosynthesis are most similar to those of O22 and genes within class IV of O139, and O22 defines the unique O antigen of O139 or O22...
  40. ncbi Sequencing and preliminary characterization of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio harveyi
    W Zhou
    Department of Biochemistry, University of Illinois at Urbana Champaign 61801, USA
    Biochemistry 38:16246-52. 1999
    ..alginolyticus and Haemophilus influenzae. Homology studies show that a number of other bacteria, including a number of pathogenic species, also have an Na(+)-NQR operon...
  41. ncbi The Vibrio cholerae O1 chromosomal integron
    C A Clark
    Microbial Pathogenesis Unit, Department of Microbiology and Immunology, University of Adelaide, Adelaide, South Australia 5005
    Microbiology 146:2605-12. 2000
    ..These data facilitate the identification of part of a new class 5 integron from V. mimicus...
  42. pmc Inorganic polyphosphate in Vibrio cholerae: genetic, biochemical, and physiologic features
    N Ogawa
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    J Bacteriol 182:6687-93. 2000
    ..cholerae. The ppk null mutant of V. cholerae has diminished adaptation to high concentrations of calcium in the medium as well as motility and abiotic surface attachment...
  43. ncbi Involvement of in vivo induced icmF gene of Vibrio cholerae in motility, adherence to epithelial cells, and conjugation frequency
    Soumita Das
    Biophysics Division, Human Genetics and Genomics Group, Indian Institute of Chemical Biology, Jadavpur, 4, Raja S C Mullick Road, Calcutta, India
    Biochem Biophys Res Commun 295:922-8. 2002
    ..We propose that the increased adherence to epithelial cell line and increased conjugation frequency of the mutant result from some sort of cell surface reorganization...
  44. ncbi Involvement of in vivo induced cheY-4 gene of Vibrio cholerae in motility, early adherence to intestinal epithelial cells and regulation of virulence factors
    Rajat Banerjee
    Biophysics Division, Indian Institute of Chemical Biology 4, Raja S C Mullick Road, Jadavpur, Calcutta 700 032, India
    FEBS Lett 532:221-6. 2002
    ..In contrast to the cheY-4 null mutant, duplication of cheY-4 gene resulted in increased expression of ctxAB and tcpA, the two major virulence genes of V. cholerae...
  45. ncbi Characterization and virulence of hemolysin III from Vibrio vulnificus
    Yu Chung Chen
    Department of Food Science, National Chung Hsing University, 250 Kuokuang Road, Taichung 402, Taiwan
    Curr Microbiol 49:175-9. 2004
    ..A hlyIII isogenic mutant was constructed via insertional inactivation and showed an attenuated virulence compared with the wild-type strain when this mutant was administered intraperitoneally in mice...
  46. ncbi LexA cleavage is required for CTX prophage induction
    Mariam Quinones
    Department of Molecular Microbiology, Tufts University School of Medicine and The Howard Hughes Medical Institute, Boston, MA 02111, USA
    Mol Cell 17:291-300. 2005
    ..LexA and RstR both bind to and repress P(rstA). Thus, CTXphi production is controlled by a cellular repressor whose activity is regulated by the cell's response to DNA damage...
  47. ncbi Structure of a trapped intermediate of calmodulin: calcium regulation of EF-hand proteins from a new perspective
    Zenon Grabarek
    Boston Biomedical Research Institute, Watertown, MA 02472, USA
    J Mol Biol 346:1351-66. 2005
    ..The model allows for a significant independence of the Ca2+-binding sites in a two-EF-hand domain...
  48. ncbi Gene cloning and characterization of four MATE family multidrug efflux pumps from Vibrio cholerae non-O1
    Anowara Begum
    Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan
    Microbiol Immunol 49:949-57. 2005
    ..Thus, all six of the MATE family multidrug efflux pumps of V. cholerae non-O1 have been characterized. We also found that all six genes were expressed in cells of V. cholerae non-O1...
  49. ncbi Freshwater bioluminescence in Vibrio albensis (Vibrio cholerae biovar albensis) NCIMB 41 is caused by a two-nucleotide deletion in luxO
    Sabu Kasai
    Department of Applied Chemistry and Bioapplied Chemistry, Graduate School of Engineering, Osaka City University, Sugimoto 3 3 138, Sumiyoshi ku, Osaka 558 8585
    J Biochem 139:471-82. 2006
    ..Here we show that the light emission in freshwater by this strain is not in conflict with our hypothesis...
  50. ncbi Expression level of heterologous tat genes is crucial for in vivo reconstitution of a functional Tat translocase in Escherichia coli
    Yanwen Xiong
    Laboratoire de Chimie Bacterienne, UPR9043, IBSM, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Biochimie 89:676-85. 2007
    ..301, Vibrio cholerae El Tor N16961, Pseudomonas aeruginosa PAO1, thermophilic Sulfolobus solfataricus P2, Thermus thermophilus HB8 and ..
  51. pmc Functional analysis of the essential GTP-binding-protein-coding gene cgtA of Vibrio cholerae
    Sangita Shah
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    J Bacteriol 190:4764-71. 2008
    ..Overexpression of V. cholerae CgtA caused distinct elongation of Escherichia coli cells. Deletion analysis indicated that the C-terminal end of CgtA plays a critical role in its proper function...
  52. doi Crystal structure of the Vibrio cholerae ferric uptake regulator (Fur) reveals insights into metal co-ordination
    Md Arif Sheikh
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK
    Mol Microbiol 72:1208-20. 2009
    ..An analysis of the metal binding properties shows that V. cholerae Fur can be activated by a range of divalent metals...
  53. pmc Integration of cyclic di-GMP and quorum sensing in the control of vpsT and aphA in Vibrio cholerae
    Disha Srivastava
    Department of Microbiology and Molecular Genetics, Michigan State University, 5180 Biomedical and Physical Sciences, East Lansing, MI 48824, USA
    J Bacteriol 193:6331-41. 2011
    ..Our results suggest that V. cholerae combines information conveyed by QS and c-di-GMP to appropriately respond and adapt to divergent environments by modulating the expression of key transcriptional regulators...
  54. pmc Interplay among cyclic diguanylate, HapR, and the general stress response regulator (RpoS) in the regulation of Vibrio cholerae hemagglutinin/protease
    Hongxia Wang
    Southern Research Institute, 2000 Ninth Avenue South, Birmingham, Alabama 35205, USA
    J Bacteriol 193:6529-38. 2011
    ..Based on the above findings, we propose a model for the interplay between HapR, RpoS, and c-di-GMP in the regulation of HA/protease expression...
  55. pmc Vibrio cholerae utilizes direct sRNA regulation in expression of a biofilm matrix protein
    Tianyan Song
    Department of Molecular Biology, Umea University, Umea, Sweden The Laboratory for Molecular Infection Medicine Sweden MIMS, Umea University, Umea, Sweden Umeå Centre for Microbial Research UCMR, Umea University, Umea, Sweden
    PLoS ONE 9:e101280. 2014
    ..cholerae. In addition, VrrA represents the first example of direct regulation of sRNA on biofilm matrix component, by-passing global master regulators. ..
  56. doi Characterization of tryptophanase from Vibrio cholerae
    Taiyeebah Nuidate
    Department of Microbiology, Faculty of Science, Prince of Songkla University, Songkhla, Hat Yai, Thailand
    Appl Biochem Biotechnol 175:243-52. 2015
    ..These sites are thus potential targets for the design of drugs to control the V. cholerae Trpase and to further investigate its functions...
  57. pmc Conformational coupling between the active site and residues within the K(C)-channel of the Vibrio cholerae cbb3-type (C-family) oxygen reductase
    Young O Ahn
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801
    Proc Natl Acad Sci U S A 111:E4419-28. 2014
    ..Other mutations of residues within or near helix α7 also perturb the active site, indicating that this helix is involved in modulation of the active site of the enzyme. ..
  58. pmc Mapping the regulon of Vibrio cholerae ferric uptake regulator expands its known network of gene regulation
    Bryan W Davies
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:12467-72. 2011
    ..cholerae Fur directly regulates several additional genes associated with Fur-binding sites, expanding the role of this transcription factor into the regulation of ribosome formation, additional transport functions, and unique sRNAs...
  59. pmc VasH is a transcriptional regulator of the type VI secretion system functional in endemic and pandemic Vibrio cholerae
    Maya Kitaoka
    Department of Medical Microbiology and Immunology, 6 22 Heritage Medical Research Center, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Bacteriol 193:6471-82. 2011
    ..cholerae strains...
  60. pmc A bacterial hemerythrin domain regulates the activity of a Vibrio cholerae diguanylate cyclase
    Ruth A Schaller
    Department of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Biochemistry 51:8563-70. 2012
    ..The non-heme diiron cofactor in the Bhr domain thus represents an alternative to heme or flavin for redox and/or diatomic gas sensing and regulation of DGC activity...
  61. ncbi The arrangement of subunits in cholera toxin
    D M Gill
    Biochemistry 15:1242-8. 1976
    ..This binding increases the effective concentration of the toxin in the vicinity of the plasma membrane. Possible ways in which A1 then crosses the membrane are considered in the Discussion...
  62. ncbi Determination of the primary structure of cholera toxin B subunit
    C Y Lai
    J Biol Chem 252:7249-56. 1977
    ..The chymotryptic peptides from the citraconylated B subunit proved to be useful in the alignment of the tryptic peptide...
  63. ncbi A homologue of the Escherichia coli DsbA protein involved in disulphide bond formation is required for enterotoxin biogenesis in Vibrio cholerae
    J Yu
    Biological Laboratory, University of Kent, Canterbury, UK
    Mol Microbiol 6:1949-58. 1992
    ....
  64. pmc Cloning, sequencing, and transcriptional regulation of the Vibrio cholerae fur gene
    C M Litwin
    Infectious Disease Unit, Massachusetts General Hospital, Boston 02114
    J Bacteriol 174:1897-903. 1992
    ..These studies identify a gene in V. cholerae homologous in both function and sequence to the fur gene of E. coli, and we have designated this gene the fur gene of V. cholerae...
  65. ncbi Purification, crystallization and preliminary crystallographic study of neuraminidase from Vibrio cholerae and Salmonella typhimurium LT2
    G Taylor
    Department of Biochemistry, University of Bath, U K
    J Mol Biol 226:1287-90. 1992
    ..2. The crystals also belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell dimensions a = 47.4 A, b = 82.8 A, c = 92.4 A, and with one molecule in the asymmetric unit. Diffraction extends to at least 1.8 A...
  66. pmc Nucleotide sequences and comparison of the hemolysin determinants of Vibrio cholerae El Tor RV79(Hly+) and RV79(Hly-) and classical 569B(Hly-)
    A E Rader
    Evans Department of Clinical Research, University Hospital, Boston, Massachusetts 02118 2393
    Infect Immun 56:1414-9. 1988
    ..In each case, the regulatory region encoding the putative hlyA promoter and the predicted 25-amino-acid signal sequence are identical...
  67. pmc Cloning of the Vibrio cholerae recA gene and construction of a Vibrio cholerae recA mutant
    I Goldberg
    J Bacteriol 165:715-22. 1986
    ..We conclude that the V. cholerae RecA protein has activities which are analogous to those described for the RecA protein of E. coli...
  68. ncbi Nucleotide sequence of ompV, the gene for a major Vibrio cholerae outer membrane protein
    J Pohlner
    Mol Gen Genet 205:494-500. 1986
    ..Such a mechanism could aid localization of the protein if export were by a contranslational secretion system...
  69. ncbi Putative O-antigen transport genes within the rfb region of Vibrio cholerae O1 are homologous to those for capsule transport
    P A Manning
    Department of Microbiology and Immunology, University of Adelaide, Australia
    Gene 158:1-7. 1995
    ..The function of RfbG is unknown, but it would appear to be a relatively hydrophilic protein and we can only speculate that it may be either a specific transferase or possibly the O-antigen polymerase...
  70. ncbi Isolation and characterization of the Vibrio cholerae acfA gene, required for efficient intestinal colonization
    K J Hughes
    Department of Microbiology and Immunology, Louisiana State University Medical Center Shreveport 71130, USA
    Gene 156:59-61. 1995
    ..The T7 expression system also showed that, in the presence of known SPI inhibitors, a 25-kDa unprocessed form of AcfA is produced...
  71. ncbi TcpA pilin sequences and colonization requirements for O1 and O139 vibrio cholerae
    J A Rhine
    Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755
    Mol Microbiol 13:1013-20. 1994
    ..abstract truncated at 250 words)..
  72. ncbi Cloning and sequencing of Vibrio cholerae mannose-sensitive haemagglutinin pilin gene: localization of mshA within a cluster of type 4 pilin genes
    G Jonson
    Department of Medical Microbiology and Immunology, Goteborg University, Sweden
    Mol Microbiol 13:109-18. 1994
    ..A potential promoter with a sequence homologous to that of cAMP-CRP-activated promoters in E. coli was identified upstream of ORF3, the gene preceding mshA...
  73. ncbi The DNA adenine methyltransferase-encoding gene (dam) of Vibrio cholerae
    R Bandyopadhyay
    Biophysics Division, Indian Institute of Chemical Biology, Calcutta
    Gene 140:67-71. 1994
    ..coli dam mutants. Homology between the nt and deduced amino acid (aa) sequences of the E. coli and V. cholerae dam genes is only 30-35%...
  74. pmc Physical linkage of the Vibrio cholerae mannose-sensitive hemagglutinin secretory and structural subunit gene loci: identification of the mshG coding sequence
    J W Marsh
    Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Infect Immun 64:460-5. 1996
    ..The nomenclature of the MSHA structural and secretory locus has been redefined accordingly...
  75. ncbi Expression and analysis of the gene for the catalytic beta subunit of the sodium-translocating NADH-ubiquinone oxidoreductase of Vibrio alginolyticus
    K Tan
    Institute for Cell and Molecular Biology, Edinburgh University, Scotland
    Biochem Soc Trans 24:12S. 1996
  76. ncbi Genetic organization and functional analysis of the otn DNA essential for cell-wall polysaccharide synthesis in Vibrio cholerae O139
    E M Bik
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Mol Microbiol 20:799-811. 1996
    ..Furthermore, a repeat motif was observed in extragenic regions. A number of observations suggest that these sequences may facilitate gene flow between V. cholerae strains and the assembly of clusters of functionally related genes...
  77. ncbi Sequence, overproduction and purification of Vibrio proteolyticus ribosomal protein L18 for in vitro and in vivo studies
    R A Setterquist
    Department of Biochemical and Biophysical Sciences, University of Houston, TX 77204 5934, USA
    Gene 183:237-42. 1996
    ..Vp His::L18 protein was also shown to incorporate into Ec ribosomes in vivo. This His-tag strategy likely will have general applicability for the study of ribosomal proteins in vitro and in vivo...
  78. ncbi Structure of TcpG, the DsbA protein folding catalyst from Vibrio cholerae
    S H Hu
    Centre for Drug Design and Development, University of Queensland, Brisbane, Australia
    J Mol Biol 268:137-46. 1997
    ....
  79. pmc Structural studies of receptor binding by cholera toxin mutants
    E A Merritt
    Department of Biological Structure, University of Washington, Seattle 98195 7742, USA
    Protein Sci 6:1516-28. 1997
    ....
  80. ncbi Cloning and sequencing of the genes for N-acetylglucosamine use that construct divergent operons (nagE-nagAC) from Vibrio cholerae non-O1
    N Yamano
    Osaka National Research Institute, Agency of Industrial Science and Technology, Japan
    Biosci Biotechnol Biochem 61:1349-53. 1997
    ..These results indicated that nagE-nagAC existed as divergent operons in V. cholerae non-O1. Unlike E. coli, nagB and nagD were not in the operons...
  81. pmc NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli
    Y Morita
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Antimicrob Agents Chemother 42:1778-82. 1998
    ..Thus, it seems that NorM and YdhE differ somehow in substrate specificity...
  82. ncbi The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site
    E A Merritt
    Department of Biological Structure, Biomolecular Structure Center, University of Washington, Seattle, WA, 98195 7742, USA
    J Mol Biol 282:1043-59. 1998
    ....
  83. pmc Vibrio cholerae VibF is required for vibriobactin synthesis and is a member of the family of nonribosomal peptide synthetases
    J R Butterton
    Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Bacteriol 182:1731-8. 2000
    ..The protein product of vibF is homologous to the multifunctional nonribosomal protein synthetases and is necessary for the biosynthesis of vibriobactin...
  84. pmc Use of RNA arbitrarily primed-PCR fingerprinting to identify Vibrio cholerae genes differentially expressed in the host following infection
    A Chakrabortty
    Biophysics Division, Indian Institute of Chemical Biology, Jadavpur, Calcutta 700 032, India
    Infect Immun 68:3878-87. 2000
    ..When V. cholerae 569B and 569BME cells were injected separately into ligated rabbit ileal loops, the transformed cells had a preference for growth in the ileal loops versus laboratory conditions...
  85. ncbi Reconstitution and characterization of the Vibrio cholerae vibriobactin synthetase from VibB, VibE, VibF, and VibH
    T A Keating
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 39:15522-30. 2000
    ..Vibriobactin synthetase is an unusual NRPS in that all intermediates are not covalently tethered as PCP thioesters and in that it represents an NRPS pathway with two branch points...
  86. ncbi Na(+) translocation by bacterial NADH:quinone oxidoreductases: an extension to the complex-I family of primary redox pumps
    J Steuber
    Mikrobiologisches Institut der Eidgenössischen Technischen Hochschule, ETH Zentrum, Schmelzbergstr 7, CH 8092, Zurich, Switzerland
    Biochim Biophys Acta 1505:45-56. 2001
    ..alginolyticus, higher (Na(+) or H(+)) transport stoichiometries are expected for complex I, suggesting the presence of a second coupling site...
  87. ncbi Na+-driven multidrug efflux pump VcmA from Vibrio cholerae non-O1, a non-halophilic bacterium
    M N Huda
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700 8530, Japan
    FEMS Microbiol Lett 203:235-9. 2001
    ..Na+ (or Li+)-dependent efflux of ethidium bromide was detected in transformant cells. Efflux of Na+, elicited by ethidium bromide, was observed from transformant cells. Thus, we concluded that the VcmA is a Na+/drug antiporter...
  88. pmc Allelic diversity and population structure in Vibrio cholerae O139 Bengal based on nucleotide sequence analysis
    M Farfan
    Departament de Microbiologia i Parasitologia Sanitaries, Divisió de Ciències de la Salut, Universitat de Barcelona, Avda Joan XXIII s n, E 08028 Barcelona, Spain
    J Bacteriol 184:1304-13. 2002
    ..Moreover, the application of the Sawyer's test and split decomposition to detect intragenic recombination in the sequenced gene fragments did not indicate the existence of recombination in our O139 population...
  89. ncbi Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes
    Jason C Pickens
    Department of Biological Structure, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Chem Biol 9:215-24. 2002
    ..The observed binding interactions can be exploited in the design of improved toxin binding inhibitors...
  90. pmc Comparative and genetic analyses of the putative Vibrio cholerae lipopolysaccharide core oligosaccharide biosynthesis (wav) gene cluster
    Jutta Nesper
    Zentrum für Infektionsforschung, Universitat Wurzburg, 97070 Wurzburg, Germany
    Infect Immun 70:2419-33. 2002
    ..cholerae virulence...
  91. ncbi MetR and CRP bind to the Vibrio harveyi lux promoters and regulate luminescence
    Jaidip Chatterjee
    Department of Biochemistry, Room 813, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6, Canada
    Mol Microbiol 46:101-11. 2002
    ....
  92. pmc A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae
    Julio Blanco
    University of Toledo, Department of Chemistry, Toledo, OH 43606, USA
    Protein Sci 12:27-33. 2003
    ..The conformational changes that do occur result primarily from NADP binding, and are localized to the repositioning of two surface loops located on the rim at opposite sides of the NADP cleft...
  93. ncbi Cloning and characterization of the groE heat-shock operon of the marine bacterium Vibrio harveyi
    Dorota Kuchanny-Ardigò
    Department of Biochemistry, University of Gdansk, Kładki 24, 80 822 Gdansk, Poland
    Microbiology 149:1483-92. 2003
    ..The results suggest that the GroEL chaperone may be more species-specific than the GroES co-chaperone...
  94. ncbi Purification and characterization of three members of the photolyase/cryptochrome family blue-light photoreceptors from Vibrio cholerae
    Erin N Worthington
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:39143-54. 2003
    ..In addition, VcCry1 exhibits RNA binding activity and co-purifies with an RNA of 60-70 nucleotides in length...
  95. ncbi Gene cloning and characterization of VcrM, a Na+-coupled multidrug efflux pump, from Vibrio cholerae non-O1
    Md Nazmul Huda
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, Okayama 700 8530, Japan
    Microbiol Immunol 47:419-27. 2003
    ..Efflux of acriflavine due to VcrM was dependent on Na+ or Li+. Moreover, Na+ efflux was observed with VcrM when TPPCl was added to Na+-loaded cells. Therefore, we conclude that VcrM is a Na+/drug antiporter-type multidrug efflux pump...
  96. pmc A K+ yptake protein, TrkA, is required for serum, protamine, and polymyxin B resistance in Vibrio vulnificus
    Yu Chung Chen
    Department of Food Science, National Chung Hsing University, Taichung, Taiwan
    Infect Immun 72:629-36. 2004
    ....
  97. ncbi The crystal structure of the periplasmic domain of the type II secretion system protein EpsM from Vibrio cholerae: the simplest version of the ferredoxin fold
    Jan Abendroth
    Department of Biochemistry, Biomolecular Structure Center, School of Medicine, University of Washington, Box 357742, Seattle, WA 98195 7242, USA
    J Mol Biol 338:585-96. 2004
    ..Unexpectedly, the fold of the periplasmic domain of EpsM is an undescribed circular permutation of the ferredoxin fold...
  98. ncbi Complementation studies of the DnaK-DnaJ-GrpE chaperone machineries from Vibrio harveyi and Escherichia coli, both in vivo and in vitro
    Michał A Zmijewski
    Department of Biochemistry, University of Gdansk, Kladki 24, 80 822 Gdansk, Poland
    Arch Microbiol 182:436-49. 2004
    ..These results indicate that, despite their high structural identity (approximately 80%) and similar mechanisms of action, the DnaK chaperones of closely related V. harveyi and E.coli bacteria differ functionally...
  99. ncbi Identification of oligopeptide permease (opp) gene cluster in Vibrio fluvialis and characterization of biofilm production by oppA knockout mutation
    Eun Mi Lee
    Department of Biotechnology and Bioengineering, Pukyong National University, Busan 608 737, Republic of Korea
    FEMS Microbiol Lett 240:21-30. 2004
    ..These results suggest that the OppA protein is involved in uptake of peptides and affects biofilm productivity...
  100. ncbi The structure of the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae: an unusual member of the actin-like ATPase superfamily
    Jan Abendroth
    Department of Biochemistry, Biomolecular Structure Center, School of Medicine, University of Washington, P O Box 357742, Seattle, WA 98195 7242, USA
    J Mol Biol 344:619-33. 2004
    ..Functional data as well as structural homology and sequence conservation suggest that domain II interacts with EpsE, the major cytoplasmic binding partner of EpsL...
  101. ncbi Oxaloacetate decarboxylase of Vibrio cholerae: purification, characterization, and expression of the genes in Escherichia coli
    Pius Dahinden
    Institut für Mikrobiologie der ETH Zürich, ETH Honggerberg, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Arch Microbiol 183:121-9. 2005
    ..The two oad gene clusters were heterologously expressed in Escherichia coli, and the decarboxylases were isolated from the host cells...

Research Grants8

  1. NEW ANIMAL MODEL FOR EHEC PATHOGENESIS AND PREVENTION
    Joan Butterton; Fiscal Year: 2004
    ..The new mouse challenge model will be compared to prior mouse models in evaluating protection from disease in response to immunization with V. cholerae strains expressing the EHEC antigens. ..
  2. EXPANDED PROTEIN STRUCTURE REFINEMENT AND VALIDATION
    Ethan Merritt; Fiscal Year: 2005
    ..This, in turn, will make it easier to identify key biological features such as the presence and conformation of bound ligands, and the nature of hinge and inter-domain motions. ..
  3. Software tools for analysis and visulaization of protein structure
    Ethan A Merritt; Fiscal Year: 2010
    ..The algorithms and computation tools developed as part of this work will be distributed freely, and we will provide web-based state of the art analysis of structures submitted by external researchers. ..
  4. Na+-pumping NADH:quinone oxidoreductase of V. cholerae
    Blanca Barquera; Fiscal Year: 2009
    ..We will also make a strong effort to crystallize Na+-NQR, since a 3-dimensional structural model is essential for a molecular-level understanding of the mechanism of the enzyme. ..
  5. Crystallography of Multi-Drug Resistant MFS Transporters
    Geoffrey Chang; Fiscal Year: 2002
    ..2. Crystallization and x-ray data collection of mdr-MFS transporters. 3. x-ray structure determination and refinement of mdr-MFS transporters. ..
  6. X-ray Structures of Small MDR Efflux Pumps
    Geoffrey Chang; Fiscal Year: 2006
    ..3. X-ray structure determination and refinement of SMR transporters.4. Structural studies of SMR transporters concerning substrate translocation.5. Structural studies of SMR transporters concerning substrate recognition. ..
  7. Crystallography of MATE Transporters
    Geoffrey Chang; Fiscal Year: 2008
    ..An x-ray structure of bacterial MATE transporters will also provide a structural basis for the translocation of substrate by homologous mammalian MOP transporters. [unreadable] [unreadable]..
  8. Structural Biology and Inhibition of MDR ABC Transporters
    Geoffrey Chang; Fiscal Year: 2009
    ..4. Structural studies of MsbA with cyclic inhibitors based on cyclosporin A and other MDR cyclopeptides (Class II MsbA inhibitors). 5. Structural studies of a new MDR-ABC transporter from H. Influenza. ..

Patents14

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  2. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  3. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  4. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
  5. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  6. Plants with increased yield by increasing or generating one or more activities in a plant or a part thereof
    Patent Number: WO2010020654-A2; Date:2010-02-25
  7. Plants with increased yield (lt)
    Patent Number: WO2010034672-A1; Date:2010-04-01
  8. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  9. Plants with increased yield (nue)
    Patent Number: WO2010046221-A1; Date:2010-04-29
  10. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  11. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  12. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  13. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  14. Process for the production of a fine chemical
    Patent Number: WO2008034648-A1; Date:2008-03-27