Dichelobacter

Summary

Alias: Dichelobacter Dewhirst et al. 1990

Top Publications

  1. Best N, Zanandrez L, Gwozdz J, Klien E, Buller N, Suter R, et al. Assessment of a rtPCR for the detection of virulent and benign Dichelobacter nodosus, the causative agent of ovine footrot, in Australia. BMC Vet Res. 2018;14:252 pubmed publisher
    ..b>Dichelobacter nodosus, the causative agent of footrot, is a gram-negative anaerobe classed into virulent and benign strains ..
  2. Bhardwaj V, Dhungyel O, de Silva K, Whittington R. Investigation of immunity in sheep following footrot infection and vaccination. Vaccine. 2014;32:6979-6985 pubmed publisher
    Ovine footrot is a major disease affecting sheep welfare and production. The anaerobic Gram-negative bacterium Dichelobacter nodosus is the essential transmitting agent. Monovalent or bivalent vaccines induce high levels of D...
  3. Kennan R, Gilhuus M, Frosth S, Seemann T, Dhungyel O, Whittington R, et al. Genomic evidence for a globally distributed, bimodal population in the ovine footrot pathogen Dichelobacter nodosus. MBio. 2014;5:e01821-14 pubmed publisher
    ..The causative agent is the Gram-negative anaerobe Dichelobacter nodosus...
  4. Kilmury S, Burrows L. The Pseudomonas aeruginosa PilSR Two-Component System Regulates Both Twitching and Swimming Motilities. MBio. 2018;9: pubmed publisher
    ..Previous studies of Geobacter sulfurreducens and Dichelobacter nodosus implicated PilR in regulation of non-T4P-related genes, including some involved in flagellar ..
  5. Locher I, Giger L, Frosth S, Kuhnert P, Steiner A. Potential transmission routes of Dichelobacter nodosus. Vet Microbiol. 2018;218:20-24 pubmed publisher
    Footrot caused by Dichelobacter nodosus is a highly contagious bacterial disease affecting the claw of sheep and the main cause of lameness in these animals. It is not only an economic burden but also a serious animal welfare issue...
  6. Moreira T, Facury Filho E, Carvalho A, Strube M, Nielsen M, Klitgaard K, et al. Pathology and bacteria related to digital dermatitis in dairy cattle in all year round grazing system in Brazil. PLoS ONE. 2018;13:e0193870 pubmed publisher
    ..Furthermore, we identify Dichelobacter nodosus in DD lesions by gene sequencing and also by fluorescent in situ hybridization in almost half of ..
  7. Dhungyel O, Schiller N, Whittington R. Identification and characterization of serogroup M Dichelobacter nodosus from sheep with virulent footrot. Vet Microbiol. 2015;176:378-81 pubmed publisher
    ..All samples were tested for Dichelobacter nodosus. A total of 1047 D...
  8. Muzafar M, Calvo Bado L, Green L, Smith E, Russell C, Grogono Thomas R, et al. The role of the environment in transmission of Dichelobacter nodosus between ewes and their lambs. Vet Microbiol. 2015;179:53-9 pubmed publisher
    b>Dichelobacter nodosus (D. nodosus) is the essential causative agent of footrot in sheep. The current study investigated when D. nodosus was detectable on newborn lambs and possible routes of transmission...
  9. Muzafar M, Green L, Calvo Bado L, Tichauer E, King H, James P, et al. Survival of the ovine footrot pathogen Dichelobacter nodosus in different soils. Anaerobe. 2016;38:81-87 pubmed publisher
    b>Dichelobacter nodosus (D. nodosus) is the causative agent of footrot in sheep; one of the most important health and welfare issues of sheep worldwide...

More Information

Publications28

  1. Kennan R, Lovitt C, Han X, Parker D, Turnbull L, Whitchurch C, et al. A two-component regulatory system modulates twitching motility in Dichelobacter nodosus. Vet Microbiol. 2015;179:34-41 pubmed publisher
    b>Dichelobacter nodosus is the essential causative agent of footrot in sheep and type IV fimbriae-mediated twitching motility has been shown to be essential for virulence...
  2. McPherson A, Dhungyel O, Whittington R. Detection and Serogrouping of Dichelobacter nodosus Infection by Use of Direct PCR from Lesion Swabs To Support Outbreak-Specific Vaccination for Virulent Footrot in Sheep. J Clin Microbiol. 2018;56: pubmed publisher
    ..can be controlled with vaccine targeting the fimbriae of virulent strains of the essential causative agent, Dichelobacter nodosus However, the bacterium is immunologically heterogeneous, and 10 distinct fimbrial serogroups have ..
  3. Jackson A, Humbert M, Pandey A, Bratcher H, Christodoulides M. Draft Genome Sequence of Dichelobacter nodosus ATCC 25549, Strain VPI 2340 [11342], a Bacterium Causing Footrot in Sheep. Genome Announc. 2015;3: pubmed publisher
    We report a draft genome sequence for Dichelobacter nodosus ATCC 25549, strain VPI 2340 [11342], a causative agent of ovine footrot. The draft genome shares ~98% gene similarity with the available genome of D...
  4. Knappe Poindecker M, Jørgensen H, Jensen T, Tesfamichael B, Ulvund M, Hektoen L, et al. Experimental infection of cattle with ovine Dichelobacter nodosus isolates. Acta Vet Scand. 2015;57:55 pubmed publisher
    b>Dichelobacter nodosus is the main causative agent of ovine footrot, and there are strong indications that the bacterium can be transferred to cattle grazing on the same pasture as sheep...
  5. Groenevelt M, Anzuino K, Smith S, Lee M, Grogono Thomas R. A case report of lameness in two dairy goat herds; a suspected combination of nutritional factors concurrent with treponeme infection. BMC Res Notes. 2015;8:791 pubmed publisher
    ..reaction (PCR) and culture of swabs taken from exposed corium and the interdigital space were negative for Dichelobacter nodosus but PCR for treponemes were positive in both the adults and the youngstock tested...
  6. Best N, Gwozdz J, Suter R, Rawlin G, Beddoe T. Direct serogrouping of Dichelobacter nodosus from Victorian farms using conventional multiplex polymerase chain reaction. BMC Res Notes. 2018;11:108 pubmed publisher
    b>Dichelobacter nodosus is the causative agent of footrot in sheep. Ovine footrot is a major problem in Australia that results in large economic losses and a represents a very significant animal welfare issue. D...
  7. Sullivan L, Clegg S, Angell J, Newbrook K, Blowey R, Carter S, et al. High-level association of bovine digital dermatitis Treponema spp. with contagious ovine digital dermatitis lesions and presence of Fusobacterium necrophorum and Dichelobacter nodosus. J Clin Microbiol. 2015;53:1628-38 pubmed publisher
    ..analyzed by PCR for the three BDD-associated Treponema phylogroups and two other lameness-associated bacteria, Dichelobacter nodosus and Fusobacterium necrophorum. Spirochete culture was also attempted on CODD lesions...
  8. Sullivan L, Evans N, Blowey R, Grove White D, Clegg S, Duncan J, et al. A molecular epidemiology of treponemes in beef cattle digital dermatitis lesions and comparative analyses with sheep contagious ovine digital dermatitis and dairy cattle digital dermatitis lesions. Vet Microbiol. 2015;178:77-87 pubmed publisher
    ..beef foot tissues (n=38) were analysed by PCR for three BDD-associated Treponema phylogroups and also for Dichelobacter nodosus and Fusobacterium necrophorum. Spirochete culture was attempted on all BDD lesion samples...
  9. Frosth S, König U, Nyman A, Pringle M, Aspán A. Characterisation of Dichelobacter nodosus and detection of Fusobacterium necrophorum and Treponema spp. in sheep with different clinical manifestations of footrot. Vet Microbiol. 2015;179:82-90 pubmed publisher
    The aim of this study was to determine the proportion of Dichelobacter nodosus, Fusobacterium necrophorum and Treponema spp...
  10. Witcomb L, Green L, Calvo Bado L, Russell C, Smith E, Grogono Thomas R, et al. First study of pathogen load and localisation of ovine footrot using fluorescence in situ hybridisation (FISH). Vet Microbiol. 2015;176:321-7 pubmed publisher
    ..b>Dichelobacter nodosus is the causative agent of ovine FR, however, the role of Fusobacterium necrophorum and other bacteria ..
  11. Farooq S, Wani S, Hassan M, Nazir N, Nyrah Q. The detection of Dichelobacter nodosus and Fusobacterium necrophorum from ovine footrot in Kashmir, India. Anaerobe. 2015;35:41-3 pubmed publisher
    ..sheep were collected in all the ten districts of the Kashmir valley and were examined for the presence of Dichelobacter nodosus (D. nodosus) and Fusobacterium necrophorum (F. necrophorum), in order to determine if F...
  12. Greber D, Bearth G, Luchinger R, Schuepbach Regula G, Steiner A. Elimination of virulent strains (aprV2) of Dichelobacter nodosus from feet of 28 Swiss sheep flocks: A proof of concept study. Vet J. 2016;216:25-32 pubmed publisher
    Virulent ovine footrot caused by Dichelobacter nodosus is an endemic disease worldwide. It is associated with severe pain, impaired animal welfare and economic losses...
  13. McPherson A, Dhungyel O, Whittington R. Evaluation of Genotypic and Phenotypic Protease Virulence Tests for Dichelobacter nodosus Infection in Sheep. J Clin Microbiol. 2017;55:1313-1326 pubmed publisher
    i>Dichelobacter nodosus is a fastidious, strictly anaerobic bacterium, an obligate parasite of the ruminant hoof, and the essential causative agent of virulent ovine footrot...
  14. Frosth S, König U, Nyman A, Aspan A. Sample pooling for real-time PCR detection and virulence determination of the footrot pathogen Dichelobacter nodosus. Vet Res Commun. 2017;41:189-193 pubmed publisher
    b>Dichelobacter nodosus is the principal cause of ovine footrot and strain virulence is an important factor in disease severity. Therefore, detection and virulence determination of D...
  15. Vinod Kumar N, Sreenivasulu D, Karthik A. Identification and characterization of Dichelobacter nodosus serogroup H from ovine footrot in India. Anaerobe. 2016;40:100-2 pubmed publisher
    ..foot swabs were collected from inter digital spaces of sheep with footrot lesions were screened for 16 rRNA of Dichelobacter nodosus by PCR. Out of the 56 samples, 38(67.85%) were found to be positive...
  16. Wani A, Sharma M, Salwan R, Singh G, Chahota R, Verma S. Cloning, Expression, and Functional Characterization of Serine Protease Aprv2 from Virulent Isolate Dichelobacter nodosus of Indian Origin. Appl Biochem Biotechnol. 2016;180:576-587 pubmed
    A gene encoding an extracellular protease from Dichelobacter nodosus was characterized and expressed in E. coli rosetta-gami (DE3)...
  17. Asheim L, Hopp P, Grøneng G, Nafstad O, Hegrenes A, Vatn S. A financial cost-benefit analysis of eradicating virulent footrot. Prev Vet Med. 2017;146:86-93 pubmed publisher
    In 2008, virulent footrot was detected in sheep in south-west Norway. Footrot is caused by Dichelobacter nodosus, and the outbreak was linked to live sheep imported from Denmark in 2005...
  18. Greber D, Locher I, Kuhnert P, Butty M, Holdener K, Frey J, et al. Pooling of interdigital swab samples for PCR detection of virulent Dichelobacter nodosus. J Vet Diagn Invest. 2017;:1040638717733508 pubmed publisher
    ..Given the development and validation of a real-time PCR to detect Dichelobacter nodosus isolates that contain the virulence-associated protease genes aprV2 and aprB2, the diagnosis of foot ..
  19. Atia J, Monaghan E, Kaler J, Purdy K, Green L, Keeling M. Mathematical modeling of ovine footrot in the UK: the effect of Dichelobacter nodosus and Fusobacterium necrophorum on the disease dynamics. Epidemics. 2017;21:13-20 pubmed publisher
    b>Dichelobacter nodosus is a virulent, invasive, anaerobic bacterium that is believed to be the causative agent of ovine footrot, an infectious bacterial disease of sheep that causes lameness...