Actinobacillus pleuropneumoniae serovar 5b str. L20


Alias: Actinobacillus pleuropneumoniae L20, Actinobacillus pleuropneumoniae serovar 5b strain L20

Top Publications

  1. Maes D, Gonzalez Ramirez L, Lopez Jaramillo J, Yu B, De Bondt H, Zegers I, et al. Structural study of the type II 3-dehydroquinate dehydratase from Actinobacillus pleuropneumoniae. Acta Crystallogr D Biol Crystallogr. 2004;60:463-71 pubmed
    ..The present structure displays the open conformation, with a sulfate anion bound in the active site. The availability of this structure opens a route to structure-based antibiotics targetting this pathogenic bacterium. ..
  2. Silva L, Yu R, Calmettes C, Yang X, Moraes T, Schriemer D, et al. Steric and allosteric factors prevent simultaneous binding of transferrin-binding proteins A and B to transferrin. Biochem J. 2012;444:189-97 pubmed publisher
    ..Thus the results of the present study support a model whereby TbpB 'hands-off' pTf to TbpA, which completes the iron removal and transport process. ..
  3. Chang N, Chen Z, Chen T, Liao J, Lin C, Chien M, et al. Elucidating the role of ApxI in hemolysis and cellular damage by using a novel apxIA mutant of Actinobacillus pleuropneumoniae serotype 10. J Vet Sci. 2014;15:81-9 pubmed
    ..Collectively, ApxI, but not other components in the exotoxin preparation of A. pleuropneumoniae serotype 10, was responsible for the hemolytic and cytotoxic effects on porcine erythrocytes and alveolar macrophages. ..
  4. Xie F, Li G, Zhang W, Zhang Y, Zhou L, Liu S, et al. Outer membrane lipoprotein VacJ is required for the membrane integrity, serum resistance and biofilm formation of Actinobacillus pleuropneumoniae. Vet Microbiol. 2016;183:1-8 pubmed publisher
    ..The data presented in this study illustrate the important role of the VacJ lipoprotein in the maintenance of cellular integrity, serum resistance, and biofilm formation in A. pleuropneumoniae. ..
  5. Xie F, Li G, Zhang Y, Zhou L, Liu S, Liu S, et al. The Lon protease homologue LonA, not LonC, contributes to the stress tolerance and biofilm formation of Actinobacillus pleuropneumoniae. Microb Pathog. 2016;93:38-43 pubmed publisher
    ..pleuropneumoniae. The data presented in this study illustrate that the LonA protease, but not the LonC protease, is required for the stress tolerance, biofilm formation and pathogenicity of A. pleuropneumoniae. ..
  6. Forest K, Langford P, Kroll J, Getzoff E. Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface. J Mol Biol. 2000;296:145-53 pubmed publisher
  7. Godara G, Smith C, Bosse J, Zeidel M, Mathai J. Functional characterization of Actinobacillus pleuropneumoniae urea transport protein, ApUT. Am J Physiol Regul Integr Comp Physiol. 2009;296:R1268-73 pubmed publisher
    ..Glycerol and urea analogs, such as methylamine, dimethylurea, formamide, acetamide, methylurea, propanamide, and ethylamine did not permeate across ApUT...
  8. Raunser S, Mathai J, Abeyrathne P, Rice A, Zeidel M, Walz T. Oligomeric structure and functional characterization of the urea transporter from Actinobacillus pleuropneumoniae. J Mol Biol. 2009;387:619-27 pubmed publisher
    ..Two-dimensional crystals of the biologically active ApUT show that it is also dimeric in a lipid membrane and provide the first structural information on a member of the UT family...
  9. Subashchandrabose S, Leveque R, Wagner T, Kirkwood R, Kiupel M, Mulks M. Branched-chain amino acids are required for the survival and virulence of Actinobacillus pleuropneumoniae in swine. Infect Immun. 2009;77:4925-33 pubmed publisher
    ..These results further suggest a potential role for AHAS inhibitors as antimicrobial agents against pulmonary pathogens...

More Information


  1. Lone A, Deslandes V, Nash J, Jacques M, MacInnes J. malT knockout mutation invokes a stringent type gene-expression profile in Actinobacillus pleuropneumoniae in bronchoalveolar fluid. BMC Microbiol. 2009;9:195 pubmed publisher
    ..Moreover, if MalT is directly or indirectly linked to the stringent response, an important global mechanism of bacterial persistence and virulence in many bacterial pathogens, it might play a role in A. pleuropneumoniae pathogenesis...
  2. Calmettes C, Yu R, Silva L, Curran D, Schriemer D, Schryvers A, et al. Structural variations within the transferrin binding site on transferrin-binding protein B, TbpB. J Biol Chem. 2011;286:12683-92 pubmed publisher
  3. Schwarz F, Fan Y, Schubert M, Aebi M. Cytoplasmic N-glycosyltransferase of Actinobacillus pleuropneumoniae is an inverting enzyme and recognizes the NX(S/T) consensus sequence. J Biol Chem. 2011;286:35267-74 pubmed publisher
    ..The identification of an enzyme that integrates some of the features of OST in a cytoplasmic pathway defines a novel class of N-linked protein glycosylation found in pathogenic bacteria...