Encephalitozoon cuniculi GB-M1

Summary

Alias:

Top Publications

  1. Koch M, Diebold M, Cavarelli J, Romier C. Crystallization and preliminary crystallographic analysis of eukaryotic transcription and mRNA export factor Iws1 from Encephalitozoon cuniculi. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:207-10 pubmed publisher
    ..Three of the crystal forms belonged to space group P2(1) and one belonged to space group P222(1). Preliminary X-ray crystallographic analysis of one of the crystal forms allowed the collection of data to 2.5 A resolution. ..
  2. Gardberg A, Sankaran B, Davies D, Bhandari J, Staker B, Stewart L. Structure of fructose bisphosphate aldolase from Encephalitozoon cuniculi. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:1055-9 pubmed publisher
    ..The quaternary structure is dimeric. This work provides a direct experimental result for the substrate-binding conformation of the product state of E. cuniculi FBPA. ..
  3. Butryn A, Schuller J, Stoehr G, Runge Wollmann P, Förster F, Auble D, et al. Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1. elife. 2015;4: pubmed publisher
    ..This study provides a structural framework for how a Swi2/Snf2 ATPase interacts with its substrate DNA:protein complex. ..
  4. Boocock G, Morrison J, Popovic M, Richards N, Ellis L, Durie P, et al. Mutations in SBDS are associated with Shwachman-Diamond syndrome. Nat Genet. 2003;33:97-101 pubmed publisher
  5. Equinet L, Bapteste E, Thellier M, Ouarzane Amara M, Vivar s C, Desportes Livage I, et al. The genes encoding cAMP-dependent protein kinase catalytic subunit homologues of the microsporidia Encephalitozoon intestinalis and E. cuniculi: molecular characterisation and phylogenetic analysis. Parasitol Int. 2004;53:277-85 pubmed publisher
    ..cuniculi orthologue (EcPKAc) is a single copy gene. RT-PCR data showed that the EiPKAc gene is expressed in at least one of the intracellular stages during infection of the mammalian host cell by E. intestinalis...
  6. Hausmann S, Zheng S, Fabrega C, Schneller S, Lima C, Shuman S. Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis. J Biol Chem. 2005;280:20404-12 pubmed publisher
    ..Amino acids Lys-54, Asp-70, Asp-78, and Asp-94, which comprise the AdoMet-binding site, and Phe-141, which contacts the cap guanosine, are essential for cap methyltransferase activity in vitro...
  7. Xu Y, Takvorian P, Cali A, Wang F, Zhang H, Orr G, et al. Identification of a new spore wall protein from Encephalitozoon cuniculi. Infect Immun. 2006;74:239-47 pubmed publisher
    ..SWP3 has several potential O-glycosylation sites, and it is possible that it is a mannosylated protein like the major polar tube protein (PTP1)...
  8. Zheng S, Hausmann S, Liu Q, Ghosh A, Schwer B, Lima C, et al. Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungin's antifungal activity. J Biol Chem. 2006;281:35904-13 pubmed publisher
    ..We find that the sensitivity of Saccharomyces cerevisiae to growth inhibition by sinefungin is diminished when Abd1 is overexpressed. These results highlight cap methylation as a principal target of the antifungal activity of sinefungin...
  9. Urch J, Hurtado Guerrero R, Brosson D, Liu Z, Eijsink V, Texier C, et al. Structural and functional characterization of a putative polysaccharide deacetylase of the human parasite Encephalitozoon cuniculi. Protein Sci. 2009;18:1197-209 pubmed publisher
    ..Thus, it appears that the ECU11_0510 protein is not a carbohydrate deacetylase and may fulfill an as yet undiscovered role in the E. cuniculi parasite. ..

More Information

Publications10

  1. Diebold M, Koch M, Loeliger E, Cura V, Winston F, Cavarelli J, et al. The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26. EMBO J. 2010;29:3979-91 pubmed publisher
    ..Taken together, our results provide new structural information about the Iws1/Spt6 complex and reveal a novel interaction domain used for the formation of transcription networks...