Magnaporthe grisea 70-15

Summary

Alias: Magnaporthe oryzae 70-15

Top Publications

  1. Clergeot P, Gourgues M, Cots J, Laurans F, Latorse M, Pepin R, et al. PLS1, a gene encoding a tetraspanin-like protein, is required for penetration of rice leaf by the fungal pathogen Magnaporthe grisea. Proc Natl Acad Sci U S A. 2001;98:6963-8 pubmed publisher
    ..We conclude that PLS1 controls an appressorial function essential for the penetration of the fungus into host leaves...
  2. Dean R, Talbot N, Ebbole D, Farman M, Mitchell T, Orbach M, et al. The genome sequence of the rice blast fungus Magnaporthe grisea. Nature. 2005;434:980-6 pubmed
    ..The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation. ..
  3. Zheng W, Zhao Z, Chen J, Liu W, Ke H, Zhou J, et al. A Cdc42 ortholog is required for penetration and virulence of Magnaporthe grisea. Fungal Genet Biol. 2009;46:450-60 pubmed publisher
    ..Furthermore, dominant negative mutation leads to a similar phenotype to that of the deletion mutants, lending further support to the conclusion that MgCdc42 is required for the penetration and virulence of M. grisea. ..
  4. Wilson R, Jenkinson J, Gibson R, Littlechild J, Wang Z, Talbot N. Tps1 regulates the pentose phosphate pathway, nitrogen metabolism and fungal virulence. EMBO J. 2007;26:3673-85 pubmed
    ..Taken together, these results demonstrate that Tps1 is a central regulator for integration of carbon and nitrogen metabolism, and plays a pivotal role in the establishment of plant disease. ..
  5. Veneault Fourrey C, Barooah M, Egan M, Wakley G, Talbot N. Autophagic fungal cell death is necessary for infection by the rice blast fungus. Science. 2006;312:580-3 pubmed
    ..Impairment of autophagy, by the targeted mutation of the MgATG8 gene, arrested conidial cell death but rendered the fungus nonpathogenic. Thus, the initiation of rice blast requires autophagic cell death of the conidium. ..
  6. Fernandez J, Wilson R. Characterizing roles for the glutathione reductase, thioredoxin reductase and thioredoxin peroxidase-encoding genes of Magnaporthe oryzae during rice blast disease. PLoS ONE. 2014;9:e87300 pubmed publisher
    ..Taken together, this work identifies components of the fungal glutathione and thioredoxin antioxidation systems as determinants of rice blast disease that act to facilitate biotrophic colonization of host cells by M. oryzae. ..
  7. Chen J, Zheng W, Zheng S, Zhang D, Sang W, Chen X, et al. Rac1 is required for pathogenicity and Chm1-dependent conidiogenesis in rice fungal pathogen Magnaporthe grisea. PLoS Pathog. 2008;4:e1000202 pubmed publisher
    ..Our data suggest that the MgRac1-Chm1 pathway is responsible for conidiogenesis, but additional pathways, including the Nox pathway, are necessary for appressorial formation and pathogenicity. ..
  8. Villalba F, Collemare J, Landraud P, Lambou K, Brozek V, Cirer B, et al. Improved gene targeting in Magnaporthe grisea by inactivation of MgKU80 required for non-homologous end joining. Fungal Genet Biol. 2008;45:68-75 pubmed
    ..These results open the way to large-scale reverse genetics experiments in M. grisea facilitating the study of the infection process. ..
  9. Zheng W, Chen J, Liu W, Zheng S, Zhou J, Lu G, et al. A Rho3 homolog is essential for appressorium development and pathogenicity of Magnaporthe grisea. Eukaryot Cell. 2007;6:2240-50 pubmed
    ..In contrast, overexpression of wild-type MgRho3 increases the infectivity of M. grisea. Our results reveal a new role for the conserved Rho3 as a critical regulator of developmental processes and pathogenicity of M. grisea. ..

More Information

Publications41

  1. Liu X, Zhuang F, Lu J, Lin F. Identification and molecular cloning Moplaa gene, a homologue of Homo sapiens PLAA, in Magnaporthe oryzae. Microbiol Res. 2011;167:8-13 pubmed publisher
    ..The Moplaa deletion mutant exhibited retarded growth and conidial germination, reduced conidiation, appressorial turgor pressure and pathogenicity to rice CO-39. Reintroduction of the gene restored defects of the Moplaa deletion mutant...
  2. Ramanujam R, Naqvi N. PdeH, a high-affinity cAMP phosphodiesterase, is a key regulator of asexual and pathogenic differentiation in Magnaporthe oryzae. PLoS Pathog. 2010;6:e1000897 pubmed publisher
    ..oryzae. We propose that PdeH-mediated sustenance and dynamic regulation of cAMP signaling during M. oryzae development is crucial for successful establishment and spread of the blast disease in rice...
  3. Yue X, Que Y, Deng S, Xu L, Oses Ruiz M, Talbot N, et al. The cyclin dependent kinase subunit Cks1 is required for infection-associated development of the rice blast fungus Magnaporthe oryzae. Environ Microbiol. 2017;19:3959-3981 pubmed publisher
    ..CKS1, therefore, encodes a conserved CDK-binding partner, essential for appressorium-mediated plant infection by the rice blast fungus. ..
  4. Peng H, Feng Y, Zhu X, Lan X, Tang M, Wang J, et al. MoDUO1, a Duo1-like gene, is required for full virulence of the rice blast fungus Magnaporthe oryzae. Curr Genet. 2011;57:409-20 pubmed publisher
    ..oryzae and its interaction with rice. ..
  5. Saitoh H, Hirabuchi A, Fujisawa S, Mitsuoka C, Terauchi R, Takano Y. MoST1 encoding a hexose transporter-like protein is involved in both conidiation and mycelial melanization of Magnaporthe oryzae. FEMS Microbiol Lett. 2014;352:104-13 pubmed publisher
    ..These results suggest that MoST1 has a specific role for conidiation and mycelial melanization, which is not shared by other hexose transporter family of M. oryzae. ..
  6. Lu J, Cao H, Zhang L, Huang P, Lin F. Systematic analysis of Zn2Cys6 transcription factors required for development and pathogenicity by high-throughput gene knockout in the rice blast fungus. PLoS Pathog. 2014;10:e1004432 pubmed publisher
    ..oryzae. ..
  7. Jacob S, Foster A, Yemelin A, Thines E. High osmolarity glycerol (HOG) signalling in Magnaporthe oryzae: Identification of MoYPD1 and its role in osmoregulation, fungicide action, and pathogenicity. Fungal Biol. 2015;119:580-94 pubmed publisher
    ..oryzae, since the mutant strain ΔMoypd1 has a white and fluffy phenotype on complete media, is not able to form spores in various conditions and fails to colonize rice plants. ..
  8. Zhang H, Zhao Q, Guo X, Guo M, Qi Z, Tang W, et al. Pleiotropic function of the putative zinc-finger protein MoMsn2 in Magnaporthe oryzae. Mol Plant Microbe Interact. 2014;27:446-60 pubmed publisher
  9. Wennman A, Oliw E, Karkehabadi S, Chen Y. Crystal Structure of Manganese Lipoxygenase of the Rice Blast Fungus Magnaporthe oryzae. J Biol Chem. 2016;291:8130-9 pubmed publisher
    ..An oxygen channel could not be identified. We conclude that Mo-MnLOX illustrates a partly unique variation of the structural theme of FeLOX. ..
  10. Zhang S, Jiang C, Zhang Q, Qi L, Li C, Xu J. Thioredoxins are involved in the activation of the PMK1 MAP kinase pathway during appressorium penetration and invasive growth in Magnaporthe oryzae. Environ Microbiol. 2016;18:3768-3784 pubmed publisher
    ..Our data indicated that thioredoxins play important roles in intra-cellular ROS signalling and pathogenesis in M. oryzae. As the predominant thioredoxin gene, TRX2 may regulate the activation of Pmk1 MAPK via its effects on Mst7. ..
  11. Romao J, Hamer J. Genetic organization of a repeated DNA sequence family in the rice blast fungus. Proc Natl Acad Sci U S A. 1992;89:5316-20 pubmed
    ..Our results indicate that the MGR586 loci are randomly distributed about the M. grisea genome and permit the construction of a well-marked linkage map useful for future studies on genome organization and genetic analysis in M. grisea. ..
  12. Shi H, Chen G, Chen Y, Dong B, Lu J, Liu X, et al. MoRad6-mediated ubiquitination pathways are essential for development and pathogenicity in Magnaporthe oryzae. Environ Microbiol. 2016;18:4170-4187 pubmed publisher
    ..oryzae. Altogether, our results suggest that MoRad6-mediated ubiquitination pathways are essential for the infection-related development and pathogenicity of M. oryzae. ..
  13. Fan G, Zhang K, Huang H, Zhang H, Zhao A, Chen L, et al. Multiprotein-bridging factor 1 regulates vegetative growth, osmotic stress, and virulence in Magnaporthe oryzae. Curr Genet. 2017;63:293-309 pubmed publisher
    ..Taken together, our data indicate that MoMBF1 is required for vegetative growth, pathogenicity and stress response in M. oryzae. ..
  14. Khan I, Wang Y, Li H, Lu J, Liu X, Lin F. Disruption and molecular characterization of calpains-related (MoCAPN1, MoCAPN3 and MoCAPN4) genes in Magnaporthe oryzae. Microbiol Res. 2014;169:844-54 pubmed publisher
    ..However, mutants for ?MoCAPN1 gene produced reduced (0.57±0.15B and 0.54±0.05B) conidia compared to that (1.69±0.13A) of the Guy-11 strain showing its involvement in conidiation. ..
  15. Zhou X, Zhao X, Xue C, Dai Y, Xu J. Bypassing both surface attachment and surface recognition requirements for appressorium formation by overactive ras signaling in Magnaporthe oryzae. Mol Plant Microbe Interact. 2014;27:996-1004 pubmed publisher
  16. Hoffmann I, Jernerén F, Oliw E. Epoxy alcohol synthase of the rice blast fungus represents a novel subfamily of dioxygenase-cytochrome P450 fusion enzymes. J Lipid Res. 2014;55:2113-23 pubmed publisher
    ..10R-DOX-EAS is the first member of a novel subfamily of DOX-CYP fusion proteins of devastating plant pathogens. ..
  17. Qi Z, Liu M, Dong Y, Yang J, Zhang H, Zheng X, et al. Orotate phosphoribosyl transferase MoPyr5 is involved in uridine 5'-phosphate synthesis and pathogenesis of Magnaporthe oryzae. Appl Microbiol Biotechnol. 2016;100:3655-66 pubmed publisher
    ..Our results also suggest that UMP biosynthesis would be a good target for the development of novel fungicides against M. oryzae. ..
  18. Matar K, Chen X, Chen D, Anjago W, Norvienyeku J, Lin Y, et al. WD40-repeat protein MoCreC is essential for carbon repression and is involved in conidiation, growth and pathogenicity of Magnaporthe oryzae. Curr Genet. 2017;63:685-696 pubmed publisher
    ..Taken together, we conclude that MoCreC is a major regulator of CCR and plays significant roles in regulating growth, conidiation, and pathogenicity of M. oryzae. ..
  19. Marroquin Guzman M, Wilson R. GATA-Dependent Glutaminolysis Drives Appressorium Formation in Magnaporthe oryzae by Suppressing TOR Inhibition of cAMP/PKA Signaling. PLoS Pathog. 2015;11:e1004851 pubmed publisher
    ..This study thus provides novel insight into the metabolic mechanisms that underpin the highly regulated process of appressorium development. ..
  20. Yun C, Motoyama T, Osada H. Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme. Nat Commun. 2015;6:8758 pubmed publisher
    ..We demonstrate that the TAS1 KS domain conducts the final cyclization step for TeA release. These results indicate that TAS1 is a unique type of NRPS-PKS hybrid enzyme. ..
  21. Deng Y, Naqvi N. A vacuolar glucoamylase, Sga1, participates in glycogen autophagy for proper asexual differentiation in Magnaporthe oryzae. Autophagy. 2010;6:455-61 pubmed publisher
    ..Our results indicate that autophagy and Sga1 act cooperatively in vacuolar glycogen breakdown, which is essential for conidia formation but dispensable for pathogenicity in Magnaporthe...
  22. Zhu X, Zhou T, Chen L, Zheng S, Chen S, Zhang D, et al. Arf6 controls endocytosis and polarity during asexual development of Magnaporthe oryzae. FEMS Microbiol Lett. 2016;363: pubmed
    ..Taken together, our data indicate that Arf6 plays an essential role in endocytosis and polarity establishment during asexual development of M. oryzae. ..
  23. Motoyama T, Kadokura K, Ohira T, Ichiishi A, Fujimura M, Yamaguchi I, et al. A two-component histidine kinase of the rice blast fungus is involved in osmotic stress response and fungicide action. Fungal Genet Biol. 2005;42:200-12 pubmed publisher
    ..In contrast, os-1 mutants of N. crassa are sensitive to high concentrations of both salts and sugars. These findings suggest that P. oryzae and N. crassa partially differ in their os (osmosensitive) signal transduction pathway...
  24. Gilbert M, Thornton C, Wakley G, Talbot N. A P-type ATPase required for rice blast disease and induction of host resistance. Nature. 2006;440:535-9 pubmed publisher
  25. Bhambra G, Wang Z, Soanes D, Wakley G, Talbot N. Peroxisomal carnitine acetyl transferase is required for elaboration of penetration hyphae during plant infection by Magnaporthe grisea. Mol Microbiol. 2006;61:46-60 pubmed publisher
    ..Taken together, our findings provide evidence that Pth2 plays a role in the generation of acetyl CoA pools necessary for appressorium function and rapid elaboration of penetration hyphae during host infection...
  26. Park G, Xue C, Zhao X, Kim Y, Orbach M, Xu J. Multiple upstream signals converge on the adaptor protein Mst50 in Magnaporthe grisea. Plant Cell. 2006;18:2822-35 pubmed publisher
    ..These results indicate that MST50 functions as an adaptor protein interacting with multiple upstream components and plays critical roles in activating the Pmk1 cascade for appressorium formation and plant infection in M. grisea...
  27. Li L, Ding S, Sharon A, Orbach M, Xu J. Mirl is highly upregulated and localized to nuclei during infectious hyphal growth in the rice blast fungus. Mol Plant Microbe Interact. 2007;20:448-58 pubmed publisher
    ..These data suggest that the expression but not the nuclear localization of MIR1 is specific to infectious hyphae and that reporter genes based on MIR1 may be suitable for monitoring infectious growth in M. grisea...
  28. Bluhm B, Zhao X, Flaherty J, Xu J, Dunkle L. RAS2 regulates growth and pathogenesis in Fusarium graminearum. Mol Plant Microbe Interact. 2007;20:627-36 pubmed publisher
    ..Based on these observations, we hypothesize that RAS2 regulates growth and virulence in F. graminearum by regulating the Gpmk1 MAP kinase pathway...
  29. Li Y, Yan X, Wang H, Liang S, Ma W, Fang M, et al. MoRic8 Is a novel component of G-protein signaling during plant infection by the rice blast fungus Magnaporthe oryzae. Mol Plant Microbe Interact. 2010;23:317-31 pubmed publisher
    ..Taken together, our results indicate that MoRic8 may act as a novel regulator of the G-protein signaling during infection-related development of rice blast fungus M. oryzae...
  30. Park C, Chen S, Shirsekar G, Zhou B, Khang C, Songkumarn P, et al. The Magnaporthe oryzae effector AvrPiz-t targets the RING E3 ubiquitin ligase APIP6 to suppress pathogen-associated molecular pattern-triggered immunity in rice. Plant Cell. 2012;24:4748-62 pubmed publisher
    ..oryzae. Taken together, our results reveal a mechanism in which a fungal effector targets the host ubiquitin proteasome system for the suppression of PAMP-triggered immunity in plants...
  31. Koharudin L, Viscomi A, Montanini B, Kershaw M, Talbot N, Ottonello S, et al. Structure-function analysis of a CVNH-LysM lectin expressed during plant infection by the rice blast fungus Magnaporthe oryzae. Structure. 2011;19:662-74 pubmed publisher
    ..Our results suggest that MGG_03307 plays a role in the early stages of plant infection...
  32. Galhano R, Illana A, Ryder L, Rodriguez Romero J, Demuez M, Badaruddin M, et al. Tpc1 is an important Zn(II)2Cys6 transcriptional regulator required for polarized growth and virulence in the rice blast fungus. PLoS Pathog. 2017;13:e1006516 pubmed publisher
    ..Consequently, Tpc1 is a core developmental regulator in filamentous fungi, linking the regulated synthesis of reactive oxygen species and the Pmk1 pathway, with polarity control during host invasion. ..